| herbal medicine practices of patients with liver cancer in peru. | the highest burden of liver cancer occurs in developing countries, where the use of herbal medicine (hm) is still widespread. despite this trend, few studies have been conducted to report hm practices of patients with a hepatic tumor in the developing world. hence, this study aimed to document the use of hm among patients with liver cancer in peru. | 2016 | 28088871 |
| beverages of lemon juice and exotic noni and papaya with potential for anticholinergic effects. | lemon (citrus limon (l.) burm. f.) juice beverages enriched either with noni (morinda citrifolia l.) (ln) or papaya (carica papaya l.) (lp), were characterized by hplc-dad-esi/ms(n), the antioxidant capacity was evaluated by (dpph·), superoxide (o2(·-)), hydroxyl radicals (·oh) and hypochlorous acid (hocl) assays, and their potential as acetylcholinesterase (ache) and butyrylcholinesterase (buche) inhibitors was also assessed. the fruits are rich in a wide range of bioactive phenolics. regarding ... | 2015 | 25306312 |
| effects of plants on osteogenic differentiation and mineralization of periodontal ligament cells: a systematic review. | this systematic review aimed to evaluate the effects of plants on osteogenic differentiation and mineralization of human periodontal ligament cells. the included studies were selected using five different electronic databases. the reference list of the included studies was crosschecked, and a partial gray literature search was undertaken using google scholar and proquest. the methodology of the selected studies was evaluated using grade. after a two-step selection process, eight studies were ide ... | 2016 | 26822584 |
| genome sequence of paenibacillus polymyxa strain cicc 10580, isolated from the fruit of noni (morinda citrifolia l.) grown in the paracel islands. | noni is a plant reported to have nutritional and therapeutic properties. paenibacillus polymyxa cicc 10580 is a strain that was isolated from the fruit of noni and showed comprehensive antagonistic activity against many pathogens. its genome was sequenced and assembled (6.10 mb). the coding sequences (cdss) correlated with antagonistic activity were annotated. | 2014 | 25169860 |
| the genetics of resistance to morinda fruit toxin during the postembryonic stages in drosophila sechellia. | although a great deal has been learned regarding the genetic changes that give rise to adaptation in bacteria and yeast, an understanding of how new complex traits arise in multicellular organisms is far less complete. many phytophagous insect species are ecological specialists that have adapted to utilize a single host plant. drosophila sechellia is a specialist that utilizes the ripe fruit of morinda citrifolia, which is toxic to its sibling species, d. simulans. here we apply multiplexed shot ... | 2015 | 26224784 |
| hypoglycemic and hepatoprotective activity of fermented fruit juice of morinda citrifolia (noni) in diabetic rats. | morinda citrifolia is a medicinal plant used to treat diabetes and liver diseases. the fermented fruit juice of the m. citrifolia (optical density = 1.25) was used to study the hypoglycemic and hepatoprotective properties in diabetes-induced rats. the rats were randomly distributed into 4 groups (control, diabetic experimental, diabetic standard, and diabetic untreated) of 6 each. diabetes was induced by administering streptozotocin (50 mg/kg body weight). fasting blood glucose, body mass, liver ... | 2010 | 20981320 |
| efficacy of passive ultrasonic irrigation with natural irrigants (morinda citrifolia juice, aloe vera and propolis) in comparison with 1% sodium hypochlorite for removal of e. faecalis biofilm: an in vitro study. | present study evaluated the efficacy of natural derivative irrigants, morinda citrifolia juice (mcj), aloe vera and propolis in comparison to 1% sodium hypochlorite with passive ultrasonic irrigation for removal of the intraradicular e. faecalis biofilms in extracted single rooted human permanent teeth. | 2013 | 23852230 |
| amelioration of apoptotic events in the skeletal muscle of intra-nigrally rotenone-infused parkinsonian rats by morinda citrifolia--up-regulation of bcl-2 and blockage of cytochrome c release. | parkinson's disease is a progressive neurodegenerative movement disorder with the cardinal symptoms of bradykinesia, resting tremor, rigidity, and postural instability, which lead to abnormal movements and lack of activity, which in turn cause muscular damage. even though studies have been carried out to elucidate the causative factors that lead to muscular damage in parkinson's disease, apoptotic events that occur in the skeletal muscle and a therapeutical approach to culminate the muscular dam ... | 2016 | 26697948 |
| damnacanthal and its nanoformulation exhibit anti-cancer activity via cyclin d1 down-regulation. | damnacanthal is an anthraquinone isolated from the root of morinda citrifolia l. (noni), and it exhibits many pharmacological properties, including anti-cancer activity. damnacanthal targets several signal transduction proteins related to cell growth inhibition or apoptosis. however, the molecular mechanisms by which damnacanthal affects cell cycle regulation have not been elucidated in detail. | 2016 | 27018445 |
| brachybacterium hainanense sp. nov., isolated from noni (morinda citrifolia l.) branch. | a gram-stain-positive bacterial strain, designated as nr2t, isolated from noni (morinda citrifolia l.) branch was investigated using a polyphasic taxonomic approach. the cells were small coccoid to ovoid, non-spore-forming and motile. phylogenetic analysis based on 16s rrna gene sequences showed that the strain was a representative of a member of the genus brachybacterium, to which the most closely related neighbours were brachybacterium squillarum m-6-3t (97.90 % similarity), brachybacterium fa ... | 2015 | 26311250 |
| uva-uvb photoprotective activity of topical formulations containing morinda citrifolia extract. | exposure to solar radiation, particularly its ultraviolet (uv) component, has a variety of harmful effects on human health. some of these effects include sunburn cell formations, basal and squamous cell cancers, melanoma, cataracts, photoaging of the skin, and immune suppression. the beneficial photoprotective effects of topical formulations with the extract, morinda citrifolia, have not been investigated. this present study aims to investigate the potential benefits of m. citrifolia topical app ... | 2014 | 25133171 |
| a locus in drosophila sechellia affecting tolerance of a host plant toxin. | many insects feed on only one or a few types of host. these host specialists often evolve a preference for chemical cues emanating from their host and develop mechanisms for circumventing their host's defenses. adaptations like these are central to evolutionary biology, yet our understanding of their genetics remains incomplete. drosophila sechellia, an emerging model for the genetics of host specialization, is an island endemic that has adapted to chemical toxins present in the fruit of its hos ... | 2013 | 24037270 |
| transformation of morinda citrifolia via simple mature seed imbibition method. | morinda citrifolia, is a valuable medicinal plant with a wide range of therapeutic properties and extensive transformation study on this plant has yet been known. present study was conducted to establish a simple and reliable transformation protocol for m. citrifolia utilising agrobacterium tumefaciens via direct seed exposure. in this study, the seeds were processed by tips clipping and dried and subsequently incubated in inoculation medium. four different parameters during the incubation such ... | 2013 | 24517006 |
| influence of various herbal irrigants as a final rinse on the adherence of enterococcus faecalis by fluorescence confocal laser scanning microscope. | the aim of this study was to assess the antibacterial efficacy of three different herbal irrigants against enterococcus faecalis. | 2013 | 23956540 |
| comparative evaluation of the antimicrobial activity of natural extracts of morinda citrifolia, papain and aloe vera (all in gel formulation), 2% chlorhexidine gel and calcium hydroxide, against enterococcus faecalis: an in vitro study. | a comparative evaluation of the antimicrobial activity of natural extracts of morinda citrifolia, papain, and aloe vera (all in gel formulations), 2% chlorhexidine gel and calcium hydroxide, against enterococcus faecalis-an in vitro study. | 2012 | 22876022 |
| use of focussed beam reflectance measurement (fbrm) for monitoring changes in biomass concentration. | the potential of focussed beam reflectance measurement (fbrm) as a tool to monitor changes in biomass concentration was investigated in a number of biological systems. the measurement technique was applied to two morphologically dissimilar plant cell suspension cultures, morinda citrifolia and centaurea calcitrapa, to a filamentous bacteria, streptomyces natalensis, to high density cultures of escherichia coli and to a murine sp2/0 hybridoma suspension cell line, 3-2.19. in all cases, the biomas ... | 2012 | 22246535 |
| antiadhesion and anti-inflammation effects of noni (morinda citrifolia) fruit extracts on ags cells during helicobacter pylori infection. | helicobacter pylori is a human gastric pathogen that adheres to host cells and injects cytotoxin-associated gene a (caga) to induce interleukin-8 (il-8), inducible nitric oxide (inos), and cyclooxygenase 2 (cox-2). noni (morinda citrifolia) is found to possess antibacteria, anti-inflammation, and antioxidation activities, but its effect on h. pylori infection is still unknown. ethanol and ethyl acetate extracts of noni fruit were used in this study. the inhibitory effect on caga and h. pylori-in ... | 2014 | 24528133 |
| antiviral activity of extracts from morinda citrifolia leaves and chlorophyll catabolites, pheophorbide a and pyropheophorbide a, against hepatitis c virus. | the development of complementary and/or alternative drugs for treatment of hepatitis c virus (hcv) infection is still needed. antiviral compounds in medicinal plants are potentially good targets to study. morinda citrifolia is a common plant distributed widely in indo-pacific region; its fruits and leaves are food sources and are also used as a treatment in traditional medicine. in this study, using a hcv cell culture system, it was demonstrated that a methanol extract, its n-hexane, and ethyl a ... | 2014 | 24438164 |
| melanogenesis-inhibitory saccharide fatty acid esters and other constituents of the fruits of morinda citrifolia (noni). | five new saccharide fatty acid esters, named nonioside p (3), nonioside q (4), nonioside r (8), nonioside s (10), and nonioside t (14), and one new succinic acid ester, butyl 2-hydroxysuccinate (=4-butoxy-3-hydroxy-4-oxobutanoic acid) (31), were isolated, along with 26 known compounds, including eight saccharide fatty acid esters, 1, 2, 5, 6, 7, 9, 12, and 13, three hemiterpene glycosides, 15, 17, and 18, six iridoid glycosides, 21-25, and 27, and nine other compounds, 20, 28, 29, and 32-37, fro ... | 2012 | 22700235 |
| the hot-water extract of leaves of noni, morinda citrifolia, promotes the immunocompetence of giant freshwater prawn, macrobrachium rosenbergii. | the hot-water morinda citrifolia leaf extract (hmle) was prepared for in vitro assessment on phenoloxidase (po) activity, respiratory bursts (rbs), and phagocytic activity (pa). furthermore, the hmle was administrated in the diet at 0.6, 3, and 6 g (kg diet)(-1) for macrobrachium rosenbergii, and the potential effects on the immunocompetence of prawns were evaluated. po activity, rbs, and pa in hemocytes incubated with the hmle at 140, 20, 20, and 140 mg l(-1) significantly increased. the immune ... | 2017 | 28359947 |
| morinda citrifolia linn. fruit (noni) juice induces an increase in no production and death of leishmania amazonensis amastigotes in peritoneal macrophages from balb/c. | leishmaniasis is a complex disease that is considered a serious public health problem. due to the absence of an effective vaccine and debilitating chemotherapy better therapies are urgently needed. this situation has stimulated the search for alternative treatments such as the use of herbal medicines. several studies conducted with morinda citrifolia linn. have shown various biological activities such as antitumor, immunomodulation and antileishmanial activity, however its mechanisms of action a ... | 2016 | 27328771 |
| a double-blind, randomized, clinical trial on the antileishmanial activity of a morinda citrifolia (noni) stem extract and its major constituents. | a controlled study was conducted to determine the efficiency of a topical ointment prepared from the stem extract of morinda citrifolia against cutaneous leishmaniasis. similarly, the in vitro antileishmanial activity of morindicone and morinthone isolated from the extract were investigated against leishmania major. these compounds displayed good activity. out of 40 patients, 50% showed an excellent response and 30% exhibited good improvement. | 2012 | 22474954 |
| protective effects of cambodian medicinal plants on tert‑butyl hydroperoxide‑induced hepatotoxicity via nrf2‑mediated heme oxygenase‑1. | liver diseases are considered to be primary contributors to morbidity and mortality rates in humans. oxidative stress is critical in liver injury, and oxidant‑induced liver injury may be caused by toxins, including tert‑butyl hydroperoxide (t‑bhp). the present study investigated the hepatoprotective activities of 64 crude ethanol extracts of cambodian medicinal plants against t‑bhp‑induced cytotoxicity in human liver‑derived hepg2 cells, and assessed their cytoprotective mechanism pertaining to ... | 2017 | 27959441 |
| expression divergence of chemosensory genes between drosophila sechellia and its sibling species and its implications for host shift. | drosophila sechellia relies exclusively on the fruits of morinda citrifolia, which are toxic to most insects, including its sibling species drosophila melanogaster and drosophila simulans. although several odorant binding protein (obp) genes and olfactory receptor (or) genes have been suggested to be associated with the d. sechellia host shift, a broad view of how chemosensory genes have contributed to this shift is still lacking. we therefore studied the transcriptomes of antennae, the main org ... | 2015 | 26430061 |
| enzymatic characterization of recombinant α-amylase in the drosophila melanogaster species subgroup: is there an effect of specialization on digestive enzyme? | we performed a comparative study on the enzymological features of purified recombinant α-amylase of three species belonging to the drosophila melanogaster species subgroup: d. melanogaster, d. erecta and d. sechellia. d. erecta and d. sechellia are specialist species, with host plant pandanus candelabrum (pandanaceae) and morinda citrifolia (rubiaceae), respectively. the temperature optima were around 57-60℃ for the three species. the ph optima were 7.2 for d. melanogaster, 8.2 for d. erecta and ... | 2013 | 24463528 |
| antimutagenic and antirecombinagenic activities of noni fruit juice in somatic cells of drosophila melanogaster. | noni, a hawaiian name for the fruit of morinda citrifolia l., is a traditional medicinal plant from polynesia widely used for the treatment of many diseases including arthritis, diabetes, asthma, hypertension and cancer. here, a commercial noni juice (tnj) was evaluated for its protective activities against the lesions induced by mitomycin c (mmc) and doxorrubicin (dxr) using the somatic mutation and recombination test (smart) in drosophila melanogaster. three-day-old larvae, trans-heterozygous ... | 2013 | 23828338 |
| recurrent specialization on a toxic fruit in an island drosophila population. | recurrent specialization on similar host plants offers a unique opportunity to unravel the evolutionary and genetic mechanisms underlying dietary shifts. recent studies have focused on ecological races belonging to the same species, but it is hard in many cases to untangle the role of adaptive introgression versus distinct mutations in facilitating recurrent evolution. we discovered on the island of mayotte a population of the generalist fly drosophila yakuba that is strictly associated with non ... | 2016 | 27044093 |
| herbal supplements and hepatotoxicity: a short review. | herbal products have gained popularity over the past few decades. the reasons attributed to the rise in popularity are cheaper costs, easy availability, patient compliance and fewer side effects. however, liver toxicity following consumption of herbal remedies is on the increase. thus, there is an urgent need to understand the mechanism of action of the herbal supplements on the liver. occasionally, herbal supplements may also interact with conventional drugs. the present review focusses on a fe ... | 2015 | 26669124 |
| evolution of acid-sensing olfactory circuits in drosophilids. | animals adapt their behaviors to specific ecological niches, but the genetic and cellular basis of nervous system evolution is poorly understood. we have compared the olfactory circuits of the specialist drosophila sechellia-which feeds exclusively on morinda citrifolia fruit-with its generalist cousins d. melanogaster and d. simulans. we show that d. sechellia exhibits derived odor-evoked attraction and physiological sensitivity to the abundant morinda volatile hexanoic acid and characterize ho ... | 2017 | 28111079 |
| genetic basis of octanoic acid resistance in drosophila sechellia: functional analysis of a fine-mapped region. | drosophila sechellia is a species of fruit fly endemic to the seychelles islands. unlike its generalist sister species, d. sechellia has evolved to be a specialist on the host plant morinda citrifolia. this specialization is interesting because the plant's fruit contains secondary defence compounds, primarily octanoic acid (oa), that are lethal to most other drosophilids. although ecological and behavioural adaptations to this toxic fruit are known, the genetic basis for evolutionary changes in ... | 2017 | 28035709 |
| dopamine drives drosophila sechellia adaptation to its toxic host. | many insect species are host-obligate specialists. the evolutionary mechanism driving the adaptation of a species to a toxic host is, however, intriguing. we analyzed the tight association of drosophila sechellia to its sole host, the fruit of morinda citrifolia, which is toxic to other members of the melanogaster species group. molecular polymorphisms in the dopamine regulatory protein catsup cause infertility in d. sechellia due to maternal arrest of oogenesis. in its natural host, the fruit c ... | 2014 | 25487989 |
| pupariation site preference within and between drosophila sibling species. | holometabolous insects pass through a sedentary pupal stage and often choose a location for pupation that is different from the site of larval feeding. we have characterized a difference in pupariation site choice within and between sibling species of drosophila. we found that, in nature, drosophila sechellia pupariate within their host fruit, morinda citrifolia, and that they perform this behavior in laboratory assays. in contrast, in the laboratory, geographically diverse strains of drosophila ... | 2013 | 24033178 |
| hybridization occurs between drosophila simulans and d. sechellia in the seychelles archipelago. | drosophila simulans and d. sechellia are sister species that serve as a model to study the evolution of reproductive isolation. while d. simulans is a human commensal that has spread all over the world, d. sechellia is restricted to the seychelles archipelago and is found to breed exclusively on the toxic fruit of morinda citrifolia. we surveyed the relative frequency of males from these two species in a variety of substrates found on five islands of the seychelles archipelago. we sampled differ ... | 2014 | 24773151 |
| drosophila yakuba mayottensis, a new model for the study of incipient ecological speciation. | a full understanding of how ecological factors drive the fixation of genetic changes during speciation is obscured by the lack of appropriate models with clear natural history and powerful genetic toolkits. in a recent study, we described an early stage of ecological speciation in a population of the generalist species drosophila yakuba (melanogaster subgroup) on the island of mayotte (indian ocean). on this island, flies are strongly associated with the toxic fruits of noni (morinda citrifolia) ... | 2017 | 27560369 |
| olfactory receptor pseudo-pseudogenes. | pseudogenes are generally considered to be non-functional dna sequences that arise through nonsense or frame-shift mutations of protein-coding genes. although certain pseudogene-derived rnas have regulatory roles, and some pseudogene fragments are translated, no clear functions for pseudogene-derived proteins are known. olfactory receptor families contain many pseudogenes, which reflect low selection pressures on loci no longer relevant to the fitness of a species. here we report the characteriz ... | 2016 | 27776356 |