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inhibition of quorum-sensing signals by essential oils.the role of quorum sensing (qs) is well known in microbial pathogenicity and antibiotic resistance. qs is responsible for motility, swarming, and biofilm production based on the signal molecules, e.g., acylated homoserine lactones (ahls) produced by micro-organisms above certain population density. the inhibition of qs may reduce pathogenicity, antibiotic resistance and biofilm formation in systemic and local infections. the homoserine lactones and other transmitters contribute to antibiotic res ...201019827025
essential oils and anxiolytic aromatherapy.a number of essential oils are currently in use as aromatherapy agents to relieve anxiety, stress, and depression. popular anxiolytic oils include lavender (lavandula angustifolia), rose (rosa damascena), orange (citrus sinensis), bergamot (citrus aurantium), lemon (citrus limon), sandalwood (santalum album), clary sage (salvia sclarea), roman chamomile (anthemis nobilis), and rose-scented geranium (pelargonium spp.). this review discusses the chemical constituents and cns effects of these aroma ...200919831048
cristispira in north american shellfish. a note on a spirillum found in oysters.ten varieties of north american shellfish were examined for the occurrence of cristispira in their styles. a cristispira was found in various numbers in ostrea virginiana, venus mercenaria, and modiola modiolus, but none in ensis americana, mya arenaria, mactra solidissima, pecten irradians, mytilus edulis, fulgur canaliculatus, or nassa obsoleta. of 298 oysters, only 128 showed the crystalline styles, in which cristispiras were present in 99. active cristispiras were found in 59 styles only and ...192119868559
differential accumulation of volatile terpene and terpene synthase mrnas during lavender (lavandula angustifolia and l. x intermedia) inflorescence development.despite the commercial importance of lavandula angustifolia mill. and l. x intermedia emeric ex loisel floral essential oils (eos), no information is currently available on potential changes in individual volatile organic compound (voc) content during inflorescence development. calyces were found to be the main sites of voc accumulation. the 20 most abundant vocs could be separated into three sub-groups according to their patterns of change in concentration the three groups of vocs sequentially ...201020002329
proboscis conditioning experiments with honeybees, apis mellifera caucasica, with butyric acid and deet mixture as conditioned and unconditioned stimuli.three experiments are described investigating whether olfactory repellents deet and butyric acid can support the classical conditioning of proboscis extension in the honeybee, apis mellifera caucasica (hymenoptera: apidae). in the first experiment deet and butyric acid readily led to standard acquisition and extinction effects, which are comparable to the use of cinnamon as a conditioned stimulus. these results demonstrate that the odor of deet or butyric acid is not intrinsically repellent to h ...201020879917
a genomics resource for investigating regulation of essential oil production in lavandula angustifolia.we are developing lavandula angustifolia (lavender) as a model system for investigating molecular regulation of essential oil (a mixture of mono- and sesquiterpenes) production in plants. as an initial step toward building the necessary 'genomics toolbox' for this species, we constructed two cdna libraries from lavender leaves and flowers, and obtained sequence information for 14,213 high-quality expressed sequence tags (ests). based on homology to sequences present in genbank, our est collectio ...201020043174
serum and plasma determination of angiogenic and anti-angiogenic factors yield different results: the need for standardization in clinical practice.the importance of an anti-angiogenic state as a mechanism of disease in preeclampsia is now recognized. assays for the determination of concentrations of soluble vascular endothelial growth factor receptor (svegfr)-1, svegfr-2, placental growth factor (plgf) and soluble endoglin (seng) have been developed for research and clinical laboratories. a key question is whether these factors should be measured in plasma or serum. the purpose of this study was to determine if there are differences in the ...201020158394
antibacterial effects of the essential oils of commonly consumed medicinal herbs using an in vitro model.the chemical composition and antibacterial activity of essential oils from 10 commonly consumed herbs: citrus aurantium, c. limon, lavandula angustifolia, matricaria chamomilla, mentha piperita, m. spicata, ocimum basilicum, origanum vulgare, thymus vulgaris and salvia officinalis have been determined. the antibacterial activity of these oils and their main components; i.e. camphor, carvacrol, 1,8-cineole, linalool, linalyl acetate, limonene, menthol, a-pinene, b-pinene, and thymol were assayed ...201021030907
chemical composition and in vitro antimicrobial activity of essential oil of melissa officinalis l. from romania.melissa officinalis l. (lemon balm) is used in traditional medicine to treat insomnia, anxiety, gastric conditions, psychiatric conditions, migraines, hypertension and bronchial conditions. natural essential oils (mixtures of fragrant chemical) obtained from various parts of plants are efficient active antimicrobial agents. the widespread use of antimicrobial agents selects resistant bacterial strains, which seriously compromise the effectiveness of antibiotic treatment. the use of herbal medici ...200820201279
antibacterial activity of essential oils from palmarosa, evening primrose, lavender and tuberose.essential oils extracted from flower petals of palmarosa (cymbopogon martini), evening primrose (primula rosea), lavender (lavandula angustifolia) and tuberose (polianthus tuberosa) were tested for their antibacterial activities against gram-positive and gram-negative bacteria. different concentrations of each essential oil ranging from 10-100% were tested. both gram-positive and gram-negative bacteria were found susceptible to the studied flower essential oils. with increase in concentration of ...200920336210
whole-genome snp association in the horse: identification of a deletion in myosin va responsible for lavender foal syndrome.lavender foal syndrome (lfs) is a lethal inherited disease of horses with a suspected autosomal recessive mode of inheritance. lfs has been primarily diagnosed in a subgroup of the arabian breed, the egyptian arabian horse. the condition is characterized by multiple neurological abnormalities and a dilute coat color. candidate genes based on comparative phenotypes in mice and humans include the ras-associated protein rab27a (rab27a) and myosin va (myo5a). here we report mapping of the locus resp ...201020419149
lavandula angustifolia essential oil as a novel and promising natural candidate for tick (rhipicephalus (boophilus) annulatus) control.lavandula angustifolia is a well known herbal medicine with a variety of useful properties, including its acaricidal effect. this experiment was carried out to study the bioacaricidal activity of l. angustifolia essential oil (eo) against engorged rhipicephalus (boophilus) annulatus (acari; ixodidae) females. for this purpose six serial concentrations (0.5, 1.0, 2.0, 4.0, 6.0 and 8.0% w/v) of l. angustifolia eo were used. there was considerable mortality in concentrations more than 4.0% although ...201020433836
biosynthesis and therapeutic properties of lavandula essential oil constituents.lavenders and their essential oils have been used in alternative medicine for several centuries. the volatile compounds that comprise lavender essential oils, including linalool and linalyl acetate, have demonstrative therapeutic properties, and the relative abundance of these metabolites is greatly influenced by the genetics and environment of the developing plants. with the rapid progress of molecular biology and the genomic sciences, our understanding of essential oil biosynthesis has greatly ...201120665367
[effects of oral care with essential oil on improvement in oral health status of hospice patients].this study was done to examine the effects of oral care with essential oil in improving the oral health status of hospice patients with terminal cancer.201020820114
essential oil composition and larvicidal activity of six mediterranean aromatic plants against the mosquito aedes albopictus (diptera: culicidae).laboratory bioassays on insecticidal activity of essential oils (eos) extracted from six mediterranean plants (achillea millefolium, lavandula angustifolia, helichrysum italicum, foeniculum vulgare, myrtus communis, and rosmarinus officinalis) were carried out against the larvae of the culicidae mosquito aedes albopictus. the chemical composition of the six eos was also investigated. results from applications showed that all tested oils had insecticidal activity, with differences in mortality ra ...201020697909
physical properties of gum karaya-starch-essential oil patches.essential oils are used in foods, cosmetics, and pharmaceuticals. despite the recent marketing of novel essential-oil-containing patches, there is no information on their production, constituents, or physical properties. the objectives of this study were to produce essential-oil patches and characterize their physical properties. the essential oil of lavandula angustifolia (lavender) was included at concentrations of 2.5% to 10% in patches manufactured from the exudate gum karaya, propylene glyc ...201020711695
in vitro and in vivo antifungal activities of the essential oils of various plants against tomato grey mould disease agent botrytis cinerea.the aim of this study was to find an alternative to synthetic fungicides currently used in the control of devastating fungal pathogen botrytis cinerea, the causal agent of grey mould disease of tomato. antifungal activities of essential oils obtained from aerial parts of aromatic plants, which belong to the lamiacea family such as origanum (origanum syriacum l. var. bevanii), lavender (lavandula stoechas l. var. stoechas) and rosemary (rosmarinus officinalis l.), were investigated against b. cin ...201020826038
genotoxicity of lavender oil, linalyl acetate, and linalool on human lymphocytes in vitro.the potential genotoxicity of lavender essential oil and its major components, linalool, and linalyl acetate, was evaluated in vitro by the micronucleus test on peripheral human lymphocytes. in the range of non-toxic concentrations (0.5-100 μg/ml), linalyl acetate increased the frequency of micronuclei significantly and in concentration-dependent manner; lavender oil did so only at the highest concentration tested, whereas linalool was devoid of genotoxicity. none of the tested substances led to ...201120839219
antidepressant-like effect of salvia sclarea is explained by modulation of dopamine activities in rats.the purpose of the present study was to screen aromatic essential oils that have antidepressant effects to identify the regulatory mechanisms of selected essential oils.201020441789
silexan, an orally administered lavandula oil preparation, is effective in the treatment of 'subsyndromal' anxiety disorder: a randomized, double-blind, placebo controlled trial.this study was performed to investigate the anxiolytic efficacy of silexan, a new oral lavender oil capsule preparation, in comparison to placebo in primary care. in 27 general and psychiatric practices 221 adults suffering from anxiety disorder not otherwise specified (diagnostic and statistical manual of mental disorders-iv 300.00 or international statistical classification of diseases and related health problems, tenth revision f41.9) were randomized to 80 mg/day of a defined, orally administ ...201020512042
lavender, tea tree and lemon oils as antimicrobials in washing liquids and soft body balms.the aim of this study was to evaluate the antimicrobial activity of commercial essential oils: lavender, tea tree and lemon, antimicrobials in washing liquid and o/w soft body balm. the inhibition efficacy of essential oils in washing liquid (1% alone or in mixtures), in soft body balm (0.5% alone), as well as combined with the synthetic preservative dmdm hydantoin and 3-iodo-2-propynyl butyl carbamate mixture (0.1 and 0.3%), was tested against s. aureus atcc 6538, p. aeruginosa atcc 9027, candi ...201120572887
an attempt of postharvest orange fruit rot control using essential oils from mediterranean plants.twelve essential oils from mediterranean aromatic plants were tested at different doses against four fungi known as causal agents of post-harvest orange fruit rot: botrytis cinerea, penicillium italicum, phytophthora citrophthora, and rhizopus stolonifer. essential oils were obtained from hyssopus officinalis, lavandula angustifolia, majorana hortensis, melissa officinalis, ocimum basilicum, origanum vulgare, salvia officinalis, and thymus vulgaris (family lamiaceae), verbena officinalis (family ...201020874226
evaluation of antioxidant potential of lavandula x intermedia emeric ex loisel. 'budrovka': a comparative study with l. angustifolia mill.a croatian indigenous cultivar of lavandin, lavandula x intermedia 'budrovka' (lamiaceae) was studied for the phenolic acids, flavonoids, anthocyanins, procyanidins and total tannins, as well as total polyphenols content, in the flower, inflorescence stalk and leaf ethanolic extracts. antioxidant potentials on these plant part extracts were assessed by the dpph free radical scavenging activity, iron chelating activity, reducing power, lipid peroxidation inhibition properties and total antioxidan ...201020877203
growth inhibition of aspergillus ochraceus zmpbf 318 and penicillium expansum zmpbf 565 by four essential oils.fungi produce a large variety of extracellular proteins, organic acids, and other metabolites and can adapt to several environmental conditions. mycotoxin-producing moulds of the genera aspergillus and penicillium are common food contaminants. one of the natural ways to protect food from mould contamination is to use essential oils. in this study, we evaluated the effect of essential oils of cinnamon, lavender, rosemary, and sage at 1 % (v/v) concentration in yeast media inoculated with spores ( ...201020587393
a systematic review on the anxiolytic effects of aromatherapy on rodents under experimentally induced anxiety models.we reviewed studies from 1999 to 2009 on anxiolytic effects of different essential oils toward rodents in anxiety-related behavioral models.201020614803
herbicidal activity of volatiles from coriander, winter savory, cotton lavender, and thyme isolated by hydrodistillation and supercritical fluid extraction.the volatiles from coriandrum sativum l., satureja montana l., santolina chamaecyparissus l., and thymus vulgaris l. were isolated by hydrodistillation (essential oil) and supercritical fluid extraction (volatile oil). their effect on seed germination and root and shoot growth of the surviving seedlings of four crops ( zea mays l., triticum durum l., pisum sativum l., and lactuca sativa l.) and two weeds ( portulaca oleracea l. and vicia sativa l.) was investigated and compared with those of two ...201020886818
the study protocol of a blinded randomised-controlled cross-over trial of lavender oil as a treatment of behavioural symptoms in dementia.the agitated behaviours that accompany dementia (e.g. pacing, aggression, calling out) are stressful to both nursing home residents and their carers and are difficult to treat. increasingly more attention is being paid to alternative interventions that are associated with fewer risks than pharmacology. lavandula angustifolia (lavender) has been thought, for centuries, to have soothing properties, but the existing evidence is limited and shows mixed results. the aim of the current study is to tes ...201020649945
phytotoxic activities of mediterranean essential oils.twelve essential oils from mediterranean aromatic plants were tested for their phytotoxic activity, at different doses, against the germination and the initial radicle growth of seeds of raphanus sativus, lactuca sativa and lepidium sativum. the essential oils were obtained from hyssopus officinalis, lavandula angustifolia, majorana hortensis, melissa officinalis, ocimum basilicum, origanum vulgare, salvia officinalis and thymus vulgaris (lamiaceae), verbena officinalis (verbenaceae), pimpinella ...201020657443
essential oils in the treatment of intestinal dysbiosis: a preliminary in vitro study.dysbiosis is associated with a number of gastrointestinal and systemic disorders. there is a need for selectively acting antimicrobial agents capable of inhibiting the growth of potentially pathogenic microorganisms, or those found to be out of balance, while not negatively impacting the bulk gastrointestinal tract microflora.200920030464
activities of ten essential oils towards propionibacterium acnes and pc-3, a-549 and mcf-7 cancer cells.ten essential oils, namely, mint (mentha spicata l., lamiaceae), ginger (zingiber officinale rosc., zingiberaceae), lemon (citrus limon burm.f., rutaceae), grapefruit (citrus paradisi macf., rutaceae), jasmine (jasminum grandiflora l., oleaceae), lavender (mill., lamiaceae), chamomile (matricaria chamomilla l., compositae), thyme (thymus vulgaris l., lamiaceae), rose (rosa damascena mill., rosaceae) and cinnamon (cinnamomum zeylanicum n. lauraceae) were tested for their antibacterial activities ...201020657472
skin application of urea-containing cream affected cutaneous arterial sympathetic nerve activity, blood flow, and water evaporation.we observed that olfactory stimulation with scent of grapefruit oil elevated the activities of sympathetic nerves, and increased the plasma glycerol concentration and blood pressure. in contrast, olfactory stimulation with scent of lavender oil had opposite effects in rats. these suggest that changes in autonomic activities cause physiological functions via histaminergic h1 and h3 receptor. moreover, it has been reported that somatic sensory stimulation affected autonomic neurotransmission. to e ...201120923465
pleiotropic effects of pigmentation genes in horses.horses are valued for the beauty and variety of colouration and coat patterning. to date, eleven different genes have been characterized that contribute to the variation observed in the horse. unfortunately, mutations involving pigmentation often lead to deleterious effects in other systems, some of which have been described in the horse. this review focuses on six such pleiotropic effects or associations with pigmentation genes. these include neurological defects (lethal white foal syndrome and ...201021070283
[effects of aromatherapy on changes in the autonomic nervous system, aortic pulse wave velocity and aortic augmentation index in patients with essential hypertension].to investigate the effectiveness of aromatherapy on blood pressure, heart rate variability, aortic pulse wave velocity and the aortic augmentation index of essential hypertensive patients.201021157172
a randomised, assessor blind, parallel group comparative efficacy trial of three products for the treatment of head lice in children--melaleuca oil and lavender oil, pyrethrins and piperonyl butoxide, and a "suffocation" product.there are many different types of pediculicides available otc in australia. in this study we compare the efficacy and safety of three topical pediculicides: a pediculicide containing melaleuca oil (tea tree oil) and lavender oil (tto/lo); a head lice "suffocation" product; and a product containing pyrethrins and piperonyl butoxide (p/pb).201020727129
xanthine oxidase inhibitory activity of the methanolic extracts of selected jordanian medicinal plants.the search for novel xanthine oxidase (xo) inhibitors with a higher therapeutic activity and fewer side effects are desired not only to treat gout but also to combat various other diseases associated with the xo activity. at present, the potential of developing successful natural products for the management of xo-related diseases is still largely unexplored. in the present study, we have screened the methanolic extracts of various jordanian medicinal plants for their xo inhibitory activities usi ...201122262935
cloning and functional characterization of β-phellandrene synthase from lavandula angustifolia.en route to building genomics resources for lavandula, we have obtained over 14,000 ests for leaves and flowers of l. angustifolia, a major essential oil crop, and identified a number of previously uncharacterized terpene synthase (tps) genes. here we report the cloning, expression in e. coli, and functional characterization of β-phellandrene synthase, laβphls. the orf--excluding the transit peptide--for this gene encoded a 62.3 kda protein that contained all conserved motifs present in plant tp ...201021165645
patent literature on mosquito repellent inventions which contain plant essential oils--a review.bites bites of mosquitoes belonging to the genera anopheles meigen, aedes meigen, culex l. and haemagogus l. are a general nuisance and are responsible for the transmission of important tropical diseases such as malaria, hemorrhagic dengue and yellow fevers and filariasis (elephantiasis). plants are traditional sources of mosquito repelling essential oils (eos), glyceridic oils and repellent and synergistic chemicals. a chemical abstracts search on mosquito repellent inventions containing plant- ...201121328177
herbal medicines, other than st. john's wort, in the treatment of depression: a systematic review.to evaluate herbal medicines, other than st. john's wort, in the treatment of depression. data sources/search methods: a computer-based search of medline, cinahl, amed, alt health watch, psych articles, psych info, current contents databases, cochrane controlled trials register, and cochrane database of systematic reviews, was performed. researchers were contacted, and bibliographies of relevant papers and previous meta-analysis were hand searched for additional references.201121438645
investigation of the effectiveness of syzygium aromaticum, lavandula angustifolia and geranium robertianum essential oils in the treatment of acute external otitis: a comparative trial with ciprofloxacin.background: antibiotics and anti-inflammatory agents are the mainstay of acute external otitis (aeo) treatment. the present study investigated the effectiveness of a combination herbal drop (lamigex) composed of essential oils from syzygium aromaticum, lavandula angustifolia, and geranium robertianum in the alleviation of aeo symptoms and compared its effects to those of ciprofloxacin 0.3% drop. methods: seventy patients were randomly assigned to receive ciprofloxacin 0.3% (n = 35) or lamigex (n ...201223274083
aqueous extract of lavender (lavandula angustifolia) improves the spatial performance of a rat model of alzheimer's disease.alzheimer's disease (ad) is one of the most important neurodegenerative disorders. it is characterized by dementia including deficits in learning and memory. the present study aimed to evaluate the effects of aqueous extract of lavender (lavandula angustifolia) on spatial performance of ad rats.201121441971
application of high-performance liquid chromatography diode array detection and mass spectrometry to the analysis of characteristic compounds in various essential oils.a high-performance liquid chromatography (hplc) method was established using an analytical reversed-phase column and gradient elution to achieve chromatographic separation of typical compounds in essential oils. for detection, a diode array detector monitoring different wavelengths simultaneously as well as a mass spectrometer (ms) were used. atmospheric pressure chemical ionization operating in the positive mode turned out to be a suitable tool to detect volatiles of different chemical classes ...201121499677
vitamin c and sugar levels as simple markers for discriminating spanish honey sources.in this work, 7 spanish honeys with different botanical origins were studied. the honey origins were rosemary, chestnut, lavender, echium, thyme, multifloral, and honeydew. the chemical compounds determined were ascorbic acid (vitamin c), hydroxymethylfurfural, and major sugar contents (glucose and fructose). the physicochemical parameters, ph, conductivity, moisture, free acidity, and color, were also measured. vitamin c is an important antioxidant in food, and the possibility to use it as disc ...201121535800
plant essential oils synergize and antagonize toxicity of different conventional insecticides against myzus persicae (hemiptera: aphididae).plant-derived products can play an important role in pest management programs. essential oils from lavandula angustifolia (lavender) and thymus vulgaris (thyme) and their main constituents, linalool and thymol, respectively, were evaluated for insecticidal activity and synergistic action in combination with insecticides against green peach aphid, myzus persicae (sulzer) (hemiptera: aphididae). the essential oils and their main constituents exerted similar insecticidal activity when aphids were e ...201526010088
chlordiazepoxide and lavender oil alter unconditioned anxiety-induced c-fos expression in the rat brain.lavender oil has a long history of use for treating anxiety, but only recent research has examined its effects using standard behavioural methods used to test novel drugs. the aim of this study was to investigate the effects of inhaled lavender oil on anxiety related behaviour of rats in the open field and to compare them with the effects of chlordiazepoxide (cdp), a typical anxiolytic drug. additionally c-fos immunochemistry was used to investigate whether lavender oil produced the same pattern ...201121641938
the effect of lavender oil on serum testosterone levels and epididymal sperm characteristics of formaldehyde treated male rats.in this study, the harmful effects of formaldehyde (fa) on serum testosterone levels and epididymal sperm characteristics were investigated. in addition, possible protective effect of lavender oil was evaluated.201121744749
preservative activity of lavender hydrosols in moisturizing body gels.the study was undertaken to verify the antimicrobial activity of lavandula angustifolia hydrosols in moisturizing body gels. the inhibition efficacy of four lavender hydrosols (obtained from fresh or dry herbs or flowers) was tested against staphylococcus aureus atcc 6538, escherichia coli atcc 1627, candida sp. łock 0008 and aspergillus niger atcc 16404 in compliance with the standards of the european pharmacopoeia commission. although the tested hydrosols did not express any remarkable antimic ...201525353363
study of organic honey from the northeast portugal.concerns about traces of numerous toxic substances and authenticity have prompted consumer demand for honey that is certified as organic, based on strict ecological, natural principles and traceability. the present study aims to characterize organic honey samples (n = 73) from northeast portugal, with respect to floral nectar origin, physicochemical parameters and microbial safety. the phenols and flavonoids contents, often referred to as responsible for honey's bioactive properties, were also a ...201121709620
[histo-anatomical researches of two subspecies of lavandula angustifolia mill].the structure of the inflorescences of two subspecies of lavandula angustifolia sl. angustifolia ssp. angustifolia and. l. angustifolia ssp. pyrenaica (d.c.) guinea+ú was studied to determine the range of variation in certain histo-anatomical characters.201121688584
antioxidant capacity and total phenolic contents of oregano (origanum vulgare), lavender (lavandula angustifolia) and lemon balm (melissa officinalis) from romania.the study reported here presents a comparative screening of three medicinal plants including oregano (origanum vulgare l.), lavender (lavandula angustifolia) and lemon balm (melissa officinalis) having the same geographical origin, the southeast region of romania, and growing in the same natural conditions. the contents of total phenolics and total flavonoids for the extracts of these were determined. furthermore, the total antioxidant capacity was also evaluated. it was found that origanum vulg ...201121707233
effect of aromatherapy on the quality of sleep in ischemic heart disease patients hospitalized in intensive care units of heart hospitals of the isfahan university of medical sciences.sleep disorder is one of the common problems patients face in icu and ccu and it is usually treated by sleeping pills. nowadays, the complementary medicine is highly considered because of its effectiveness and safety. aromatherapy is one of the holistic nursing cares which sees human beings as a biological, mental and social unit while the psychological dimension has the central role. each of these dimensions is dependent on each other and is affected by each other. therefore, it is fundamental ...201022049287
liquid and vapour-phase antifungal activities of essential oils against candida albicans and non-albicans candida.the management of candida infections faces many problems, such as a limited number of antifungal drugs, toxicity, resistance of candida to commonly antifungal drugs, relapse of candida infections, and the high cost of antifungal drugs. though azole antifungal agents and derivatives continue to dominate as drugs of choice against candida infections, there are many available data referring to the anticandidal activity of essential oils. since we have previous observed a good antimicrobial activity ...201627576581
Toxicity of essential and non-essential oils against the chewing louse, Bovicola (Werneckiella) ocellatus.The toxicity of six plant essential oils to the chewing louse, Bovicola (Werneckiella) ocellatus collected from donkeys, was examined in laboratory bioassays. The oils examined were: tea-tree (Melaleuca alternifolia), lavender (Lavandula angustifolia), peppermint (Mentha piperita), eucalyptus (Eucalyptus globulus Labillardiere), clove bud (Eugenia caryophyllata) and camphor (Cinnamomum camphora). All except camphor oil showed high levels of toxicity, with significant dose-dependent mortality and ...201122177577
rhamnolipids as emulsifying agents for essential oil formulations: antimicrobial effect against candida albicans and methicillin-resistant staphylococcus aureus.this work examines the influence of essential oil composition on emulsification with rhamnolipids and their use as therapeutic antimicrobial agents against two opportunistic pathogens, methicillin-resistant staphylococcus aureus (mrsa) and candida albicans. rhamnolipids, produced by pseudomonas aeruginosa, with waste frying oil as the carbon source, were composed of eight rhamnolipid homologues. the rhamnolipid mixture was used to produce emulsions containing essential oils (eos) of melaleuca al ...201425269010
A large foodborne outbreak of norovirus in diners at a restaurant in England between January and February 2009.SUMMARYAn outbreak of gastroenteritis affected at least 240 persons who had eaten at a gourmet restaurant over a period of 7 weeks in 2009 in England. Epidemiological, microbiological, and environmental studies were conducted. The case-control study demonstrated increased risk of illness in those who ate from a special 'tasting menu' and in particular an oyster, passion fruit jelly and lavender dish (odds ratio 7·0, 95% confidence interval 1·1-45·2). Ten diners and six staff members had laborato ...201122129511
an ex vivo, assessor blind, randomised, parallel group, comparative efficacy trial of the ovicidal activity of three pediculicides after a single application--melaleuca oil and lavender oil, eucalyptus oil and lemon tea tree oil, and a "suffocation" pediculicide.there are two components to the clinical efficacy of pediculicides: (i) efficacy against the crawling-stages (lousicidal efficacy); and (ii) efficacy against the eggs (ovicidal efficacy). lousicidal efficacy and ovicidal efficacy are confounded in clinical trials. here we report on a trial that was specially designed to rank the clinical ovicidal efficacy of pediculicides. eggs were collected, pre-treatment and post-treatment, from subjects with different types of hair, different coloured hair a ...201121864348
evaluation of the effects of plant-derived essential oils on central nervous system function using discrete shuttle-type conditioned avoidance response in mice.although plant-derived essential oils (eos) have been used to treat various mental disorders, their central nervous system (cns) acting effects have not been clarified. the present study compared the effects of 20 kinds of eos with the effects of already-known cns acting drugs to examine whether the eos exhibited cns stimulant-like effects, cns depressant-like effects, or neither. all agents were tested using a discrete shuttle-type conditioned avoidance task in mice. essential oils of peppermin ...201122086772
subconscious olfactory influences of stimulant and relaxant odors on immune function.brain and immune system are linked by bidirectional pathways so that changes of the central nervous system may influence various immune functions. the olfactory system may be involved in this interaction. in most odor studies subjects are aware of an odor exposure, using frequently high odor concentrations or long-term exposures without controls. in this pilot study, the potential immune effects of short-term odor exposure were examined in 32 blinded subjects (16 male, 16 female). subjects were ...201122159968
aroma-therapeutic effects of massage blended essential oils on humans.although blended essential oils are increasingly being used for the improvement of the quality of life and for the relief of various symptoms in patients, the scientific evaluation of the aroma-therapeutic effects of blended essential oils in humans is rather scarce. in this study, we hypothesized that applying blended essential oil would provide a synergistic effect that would have a chance for success in treating depression or anxiety. therefore, the main objective of this study was to investi ...201121922934
antibacterial activity against clostridium genus and antiradical activity of the essential oils from different origin.in the present study, the antimicrobial and antiradical activities of 15 essential oils were investigated. the antimicrobial activities were determined by using agar disc diffusion and broth microdilution methods against clostridium genus and antioxidant properties of essential oils by testing their scavenging effect on dpph radicals activities. we determined the antibacterial activity of clostridium butyricum, clostridium hystoliticum, clostridium intestinale, clostridium perfringens and clostr ...201424813985
[Sensitivity assessment of thyme and lavender essential oils against clinical strains of Escherichia coli for their resistance].Strong antiseptic activity of plant essential oils and extracts has been known for a long time. The antibacterial activity of thyme and lavender essential oils were tested against 30 clinical bacterial strains of Escherichia coli from patients with different clinical conditions. The agar diffusion method was used for microbial growth inhibition at various concentrations of the oils from Thymus vulgaris and Lavandula angustifolia. Susceptibility testing to antibiotics and chemotherapeutics was ca ...201122184923
volatile chemical composition and bioactivity of six essential oils against the stored food insect sitophilus zeamais motsch. (coleoptera dryophthoridae).essential oils (eos) of achillea millefolium, myrtus communis, rosmarinus officinalis, helichrysum italicum, foeniculum vulgare and lavandula angustifolia were analysed with gc-fid and gc-ms in order to define their aromatic profiles and then their toxicity and repellent activity against sitophilus zeamais motsch. (coleoptera dryophthoridae) with specific bioassays were evaluated. results from topical applications on insects showed that all eos had variable and significant insecticidal activity. ...201121861644
Genetic differences in temperament determine whether lavender oil alleviates or exacerbates anxiety in sheep.Growing concerns about the risk of addiction to benzodiazepines have led to increasing interest in alternative therapies to treat anxiety and depression. Lavender oil (Lavendula augustifolia) is reportedly anxiolytic in a number of species but little is known about how it affects individuals that are more or less anxious when faced with a stressor. In this study, we used changes in locomotor activity and the plasma concentrations of cortisol to test whether lavender oil would reduce behavioral a ...201122192707
Anti-inflammatory, anti-oxidant, and apoptotic activities of four plant species used in folk medicine in the Mediterranean basin.The aim of this research was to study the potential anti-inflammatory activity of myrtle (Myrtus communis), sarsaparilla (Smilax aspera), Arabian or French lavender (Lavandula stoechas), and calamint (Calamintha nepeta) along with their apoptotic effects on the pro-inflammatory cells, and the correlation of these effects with the plants' potential anti-oxidant activity. Myrtle extract exhibited the highest inhibitory activity in the paw oedema induced by carrageenan (60% at 3 h), whereas calamin ...201222186311
antibacterial activity of thyme and lavender essential oils.strong antiseptic activity of essential oils has been known for a long time. the antibacterial activity of oils was tested against clinical bacterial strains of staphylococcus, enterococcus, escherichia and pseudomonas genera. the agar diffusion method was used for microbial growth inhibition at various concentrations of the oils from t. vulgaris and l. angustifolia. susceptibility testing to antibiotics and chemotherapeutics was carried out using disc-diffusion method. 120 strains of bacteria i ...201122313307
interspecies comparison of chemical composition and anxiolytic-like effects of lavender oils upon inhalation.essential oils have traditionally been used for decades to alleviate the symptoms of various mental problems. in terms of anxiolytic-like properties, lavender oil is probably the most commonly used and best-studied essential oil. although there is compositional variance among the oils extracted from different origins, there have been few studies performed to date to investigate how these differences affect the expression of anxiolytic-like activity. this paper discusses the interspecies differen ...201122224307
substrate promiscuity of a rosmarinic acid synthase from lavender (lavandula angustifolia l.).one of the most common types of modification of secondary metabolites is the acylation of oxygen- and nitrogen-containing substrates to produce esters and amides, respectively. among the known acyltransferases, the members of the plant bahd family are capable of acylating a wide variety of substrates. two full-length acyltransferase cdnas (laat1 and 2) were isolated from lavender flowers (lavandula angustifolia l.) by reverse transcriptase-pcr using degenerate primers based on bahd sequences. re ...201121424826
immunological and psychological benefits of aromatherapy massage.this preliminary investigation compares peripheral blood cell counts including red blood cells (rbcs), white blood cells (wbcs), neutrophils, peripheral blood lymphocytes (pbls), cd4(+), cd8(+) and cd16(+) lymphocytes, cd4(+)/cd8(+) ratio, hematocrit, humoral parameters including serum interferon-gamma and interleukin-6, salivary secretory immunoglobulin a (iga). psychological measures including the state-trait anxiety inventory (stai) questionnaire and the self-rating depression scale (sds) bet ...200515937558
high antiviral effects of hibiscus tea extract on the h5 subtypes of low and highly pathogenic avian influenza viruses.viral neuraminidase inhibitors are widely used as synthetic anti-influenza drugs for the prevention and treatment of influenza. however, drug-resistant influenza a virus variants, including h5n1 highly pathogenic avian influenza viruses (hpaivs), have been reported. therefore, the discovery of novel and effective antiviral agents is warranted. we screened the antiviral effects of 11 herbal tea extracts (hibiscus, black tea, tencha, rosehip tea, burdock tea, green tea, jasmine tea, ginger tea, la ...201627193820
chemical composition, antioxidant and antimicrobial activity of essential oils from organic fennel, parsley, and lavender from spain.the aim of this work was to (i) determine the chemical composition of the essential oils of three spices widely cultivated in spain from organic growth: foeniculum vulgare, petroselium crispum, and lavandula officinalis; (ii) determine the total phenolic content; (iii) determine the antioxidant activity of the essentials oils by means of three different antioxidant tests and (iv) determine the effectiveness of these essentials oils on the inhibition of listeria innocua cect 910 and pseudomonas f ...201628231113
linking bacterial endophytic communities to essential oils: clues from lavandula angustifolia mill.endophytic bacteria play a crucial role in plant life and are also drawing much attention for their capacity to produce bioactive compounds of relevant biotechnological interest. here we present the characterisation of the cultivable endophytic bacteria of lavandula angustifolia mill.-a species used since antiquity for its therapeutic properties-since the production of bioactive metabolites from medical plants may reside also in the activity of bacterial endophytes through their direct productio ...201424971151
antimicrobial activity of essential oils and carvacrol, and synergy of carvacrol and erythromycin, against clinical, erythromycin-resistant group a streptococci.in the present study, we have evaluated the in vitro antibacterial activity of essential oils from origanum vulgare, thymus vulgaris, lavandula angustifolia, mentha piperita, and melaleuca alternifolia against 32 erythromycin-resistant [mininum inhibitory concentration (mic) ≥1 μg/ml; inducible, constitutive, and efflux-mediated resistance phenotype; erm(tr), erm(b), and mef(a) genes] and cell-invasive group a streptococci (gas) isolated from children with pharyngotonsillitis in italy. over the pa ...201525784902
the biological activities of cinnamon, geranium and lavender essential oils.acinetobacter sp. represent an important cause of nosocomial infections. their resistance to some antibiotics, their ability to survive on inanimate surfaces in the hospital environment and their ability to produce biofilms contributes to their virulence. the aim of the study was to determine the antibacterial properties of cinnamon, lavender and geranium essential oils against bacteria of the genus acinetobacter isolated from several clinical materials and from the hospital environment. a compr ...201425514231
antimicrobial impacts of essential oils on food borne-pathogens.the antimicrobial activity of twelve essential oil (pine oil, eucalyptus, thyme, sage tea, lavender, orange, laurel, lemon, myrtle, lemon, rosemary and juniper) was tested by a disc diffusion method against food borne pathogens (escherichia coli, salmonella paratyphi a, klebsiella pneumoniae, yersinia enterocolitica, pseudomonas aeruginosa, aeromonas hydrophila, campylobacter jejuni, enterococcus faecalis, staphylococcus aureus). the major components in essential oils were monoterpenes hydrocarb ...201526072990
antifungal screening of lavender essential oils and essential oil constituents on three post-harvest fungal pathogens.a growing body of literature indicates that many synthetic pesticides have adverse effects on human, animal, and environmental health. as a result, plant-derived natural products are quickly gaining momentum as safer and less ecologically damaging alternatives due to their low toxicity, high biodegradability, and good specificity. essential oils of lavandula angustifolia, lavandula x intermedia cv grosso, and lavandida x intermedia cv provence as well as various mono- and sesquiterpene essential ...201627396210
efficacy of plant essential oils on postharvest control of rots caused by fungi on different stone fruits in vivo.the antifungal activity of plant essential oils was evaluated as postharvest treatment on stone fruit against brown rot and grey mold rot of stone fruit caused by monilinia laxa and botrytis cinerea, respectively. the essential oils from basil (ocimum basilicum), fennel (foeniculum sativum), lavender (lavandula officinalis), marjoram (origanum majorana), oregano (origanum vulgare), peppermint (mentha piperita), rosemary (rosmarinus officinalis), sage (salvia officinalis), savory (satureja montan ...201323575125
the in vitro antimicrobial effects of lavandula angustifolia essential oil in combination with conventional antimicrobial agents.the paper focuses on the in vitro antimicrobial activity of lavandula angustifolia mill. (lavender) essential oil in combination with four commercial antimicrobial agents. stock solutions of chloramphenicol, ciprofloxacin, nystatin, and fusidic acid were tested in combination with l. angustifolia essential oil. the antimicrobial activities of the combinations were investigated against the gram-positive bacterial strain staphylococcus aureus (atcc 6538) and gram-negative pseudomonas aeruginosa (a ...201627891157
sensitivity of candida albicans to essential oils: are they an alternative to antifungal agents?candida albicans is an important opportunistic pathogen, responsible for the majority of yeast infections in humans. essential oils, extracted from aromatic plants, are well-known antimicrobial agents, characterized by a broad spectrum of activities, including antifungal properties. the aim of this work was to assess the sensitivity of 30 different vaginal isolated strains of c. albicans to 12 essential oils, compared to the three main used drugs (clotrimazole, fluconazole and itraconazole).201627568869
antifungal effect of lavender essential oil (lavandula angustifolia) and clotrimazole on candida albicans: an in vitro study.background. the treatment of candidiasis infections is an important problem in the health care system. this study aimed to investigate the in vitro effect of lavender essential oil and clotrimazole on isolated c. albicans from vaginal candidiasis. materials and methods. in this clinical trial, c. albicans isolated from the vaginal discharge samples was obtained. results. the pairwise comparison showed that lavender and clotrimazole had a significant difference; this difference in the lavender gr ...201526550521
antimicrobial efficacy of five essential oils against oral pathogens: an in vitro study.this study was aimed to find out the minimum inhibitory concentration (mic) of five essential oils against oral pathogens and to find out the minimum bactericidal concentration (mbc) and minimum fungicidal concentration (mfc) of five essential oils against oral pathogens.201324966732
all-natural composite wound dressing films of essential oils encapsulated in sodium alginate with antimicrobial properties.we present natural polymeric composite films made of essential oils (eos) dispersed in sodium alginate (naalg) matrix, with remarkable anti-microbial and anti-fungal properties. namely, elicriso italic, chamomile blue, cinnamon, lavender, tea tree, peppermint, eucalyptus, lemongrass and lemon oils were encapsulated in the films as potential active substances. glycerol was used to induce plasticity and surfactants were added to improve the dispersion of eos in the naalg matrix. the topography, ch ...201424211443
antimicrobial activity of blended essential oil preparation.antimicrobial activities of two blended essential oil preparations comprising lavender oil, petigrain oil, clary sage oil, ylang ylang oil and jasmine oil were evaluated against various pathogenic microorganisms. both preparations showed antimicrobial activity in the agar disc diffusion assay against the gram-positive bacteria, staphylococcus aureus atcc6538 and s. epidermidis isolated strain, the fungus, candida albicans atcc10231, and the gram-negative bacterium, escherichia coli atcc25922, bu ...201223157022
efficacy of plant extracts and oils as mosquito repellents.some natural products, extract of achillea millefolium (yarrow), birch/pine tar-, citronella-, clove-, eucalyptus-, geranium-, lavender-, lily of the valley- and peppermint oils have been tested for repellency in the laboratory against aedes aegypti and in the field predominantly against aedes communis and a. cinereus. the laboratory tests showed that yarrow extract exhibited a similar repellency as the reference substances n,n-diethyl-m-toluamide and n,n-diethyl-mandelic acid amide. a good repe ...199823195905
essential oils to control ichthyophthiriasis in pacu, piaractus mesopotamicus (holmberg): special emphasis on treatment with melaleuca alternifolia.in vitro effect of the melaleuca alternifolia, lavandula angustifolia and mentha piperita essential oils (eos) against ichthyophthirius multifiliis and in vivo effect of m. alternifolia for treating ichthyophthiriasis in one of the most important south american fish, piaractus mesopotamicus (holmberg), were evaluated. the in vitro test consisted of three eos, each at concentrations of 57 μl l(-1) , 114 μl l (-1) , 227 μl l(-1) and 455 μl l (-1) , which were assessed once an hour for 4 h in micro ...201626776242
adverse effects of herbal medicines: an overview of systematic reviews.this overview of systematic reviews (srs) aims to evaluate critically the evidence regarding the adverse effects of herbal medicines (hms). five electronic databases were searched to identify all relevant srs, with 50 srs of 50 different hms meeting our inclusion criteria. most had only minor weaknesses in methods. serious adverse effects were noted only for four hms: herbae pulvis standardisatus, larrea tridentate, piper methysticum and cassia senna. the most severe adverse effects were liver o ...201323472485
medicinal lavender modulates the enteric microbiota to protect against citrobacter rodentium-induced colitis.inflammatory bowel disease, inclusive of crohn's disease and ulcerative colitis, consists of immunologically mediated disorders involving the microbiota in the gastrointestinal tract. lavender oil is a traditional medicine used to relieve many gastrointestinal disorders. the goal of this study was to examine the therapeutic effects of the essential oil obtained from a novel lavender cultivar, lavandula×intermedia cultivar okanagan lavender (oleo), in a mouse model of acute colitis caused by citr ...201222821949
linalool affects the antimicrobial efficacy of essential oils.the high concentrations of essential oils are generally required to receive microbial purity of the products (cosmetics, medicine). on the other hand, their application due to the high concentration of essential oils may be limited by changes in organoleptic and textural quality of the products, as well as they cause irritation and allergies in users. addition of linalool to essential oil may significantly enhance its antimicrobial effectiveness and reduce their concentrations in products, takin ...201626553262
carbon partitioning to the terpenoid biosynthetic pathway enables heterologous β-phellandrene production in escherichia coli cultures.escherichia coli was used as a microbial system for the heterologous synthesis of β-phellandrene, a monoterpene of plant origin with several potential commercial applications. expression of lavandula angustifolia β-phellandrene synthase (phls), alone or in combination with picea abies geranyl-diphosphate synthase in e. coli, resulted in no β-phellandrene accumulation, in sharp contrast to observations with phls-transformed cyanobacteria. lack of β-phellandrene biosynthesis in e. coli was attribu ...201425116411
membrane disruption and anti-quorum sensing effects of synergistic interaction between lavandula angustifolia (lavender oil) in combination with antibiotic against plasmid-conferred multi-drug-resistant escherichia coli.the aim of this study was to investigate the mode of action of the lavender essential oil (lv) on antimicrobial activity against multi-drug-resistant escherichia coli j53 r1 when used singly and in combination with piperacillin.201424779580
combination of essential oils and antibiotics reduce antibiotic resistance in plasmid-conferred multidrug resistant bacteria.in this study we investigated the relationship between several selected commercially available essential oils and beta-lactam antibiotics on their antibacterial effect against multidrug resistant bacteria. the antibacterial activity of essential oils and antibiotics was assessed using broth microdilution. the combined effects between essential oils of cinnamon bark, lavender, marjoram, tea tree, peppermint and ampicillin, piperacillin, cefazolin, cefuroxime, carbenicillin, ceftazidime, meropenem ...201323537749
potential application of aromatic plant extracts to prevent cheese blowing.this study aimed to inhibit the growth of escherichia coli and clostridium tyrobutyricum, common bacteria responsible for early and late cheese blowing defects respectively, by using novel aqueous extracts obtained by dynamic solid-liquid extraction and essential oils obtained by solvent free microwave extraction from 12 aromatic plants. in terms of antibacterial activity, a total of 13 extracts inhibited one of the two bacteria, and only two essential oils, lavandula angustifolia mill. and lava ...201323417280
the biosynthetic origin of irregular monoterpenes in lavandula: isolation and biochemical characterization of a novel cis-prenyl diphosphate synthase gene, lavandulyl diphosphate synthase.lavender essential oils are constituted predominantly of regular monoterpenes, for example linalool, 1,8-cineole, and camphor. however, they also contain irregular monoterpenes including lavandulol and lavandulyl acetate. although the majority of genes responsible for the production of regular monoterpenes in lavenders are now known, enzymes (including lavandulyl diphosphate synthase (lpps)) catalyzing the biosynthesis of irregular monoterpenes in these plants have not been described. here, we r ...201323306202
cloning, functional characterization and genomic organization of 1,8-cineole synthases from lavandula.several members of the genus lavandula produce valuable essential oils (eos) that are primarily constituted of the low molecular weight isoprenoids, particularly monoterpenes. we isolated over 8,000 ests from the glandular trichomes of l. x intermedia flowers (where bulk of the eo is synthesized) to facilitate the discovery of genes that control the biosynthesis of eo constituents. the expression profile of these ests in l. x intermedia and its parents l. angustifolia and l. latifolia was establ ...201222592779
antifungal effect of lavender honey against candida albicans , candida krusei and cryptococcus neoformans.monofloral lavender honey samples (n = 30), were analyzed to test antifungal effect against candida albicans, candida krusei, and cryptococcus neoformans. the specific growth rates (μ) showed that all the yeast growths were reduced in the presence of honey. the honey concentration (% w/v) that inhibited 10% of the yeasts growth (x min) ranged from 31.0% (c. albicans), 16.8% (c. krusei) and 23.0% (c. neoformans). a synthetic honey solution was also tested to determine antifungal activity attribut ...201123572800
effects of inhaled lavender essential oil on stress-loaded animals: changes in anxiety-related behavior and expression levels of selected mrnas and proteins.inhalation of various essential oils elicits behavioral changes as a consequence of a complex centrally coordinated response. to understand the molecular mechanisms of action of aromatic compounds on emotional responses, we evaluated the stress-induced changes in mouse brain and the efficacy of inhaled essential oil from lavandula officinalis (lveo) using two approaches: a behavioral test, and examining the expression levels of selected genes {fast nerve growth factor receptor (ngfr) mrna, activ ...201223285826
anti-inflammatory potential of ursolic acid in mycobacterium tuberculosis-sensitized and concanavalin a-stimulated cells.ursolic acid (3-β-3-hydroxy-urs-12-ene-28-oic-acid; ua) is a triterpenoid carboxylic acid with various pharmaceutical properties. it is commonly found in apples, basil, berries, rosemary, peppermint, lavender, oregano, thyme, hawthorn and prunes. in the present study, the activities of ua against the mycobacterium tuberculosis h37rv‑induced release of a panel of inflammatory cytokines, including tumor necrosis factor-α (tnf-α), interleukin (il)-1β and il-6 from raw 264.7 murine macrophages, a549 ...201626847129
antifungal activity of essential oils against selected terverticillate penicillia.the aim of this study was to screen 15 essential oils of selected plant species, viz. lavandula angustifolia, carum carvi, pinus mungo var. pulmilio, mentha piperita, chamomilla recutita l., pinus sylvestris, satureia hortensis l., origanum vulgare l., pimpinella anisum, rosmarinus officinalis l., salvia officinalis l., abietis albia etheroleum, chamomilla recutita l. rausch, thymus vulgaris l., origanum vulgare l. for antifungal activity against five penicillium species: penicillium brevicompac ...201525780826
pseudomonas aeruginosa mastitis in two goats associated with an essential oil-based teat dip.pseudomonas aeruginosa is an opportunistic pathogen that has been associated with mastitis in dairy animals, including goats. often, the environmental sources of the bacteria are water-related (such as hoses and muddy pastures). mastitis attributable to p. aeruginosa was identified in 2 goats in a small herd. efforts were made to identify environmental sources of the pathogen. multiple samples from the goats' environment were cultured, including water from the trough, bedding, the hose used to w ...201627698173
comparison of chemical composition and antibacterial activity of lavender varieties from poland.the aim of the study was comparing the chemical composition of the essential oils from five varieties of lavender (lavandula angustifolia l.), and its biological activity against two pathogenic bacteria, staphylococcus aureus and pseudomonas aeruginosa. in the comparison we included the following varieties: 'munstead', 'munstead strain', 'lavender lady', 'ellegance purple' and 'blue river'. selected varieties of lavender (l. angustifolia) are characterised by exactly the same main compounds with ...201322989360
antibacterial and antioxidant potency of floral honeys from different botanical and geographical origins.in order to assess their physicochemical and antioxidant properties as well as their antimicrobial potency, four varieties of honey from different botanical and geographical origins were used. the agar incorporation method was used to determine the antimicrobial potency of honeys. the total phenol content was determined by a modified folin-ciocalteu method and the free radical scavenging activity by the fe(3+)reducing power (frap) assay. manuka honey was the most effective against staphylococcus ...201222948516
metabolic engineering of saccharomyces cerevisiae for linalool production.to engineer the yeast saccharomyces cerevisiae for the heterologous production of linalool.201626614300
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