| blood sucking activities of hookworms. routes and quantities of blood loss in ancylostoma caninum, a duodenale and a ceylanicum infections. | | 1983 | 6413142 |
| host immune response against homologous challenge infection of ancylostoma caninum larvae after application of effective anthelmintics. | the development of immunity against ancylostoma caninum larval reinfection has been investigated in mice after the primary infection has been treated with an effective anthelmintics. experimentally a, caninum larvae infected mice treated with levamisole (5 x 40 mg/kg), thiabendazole (5 x 200 mg/kg), oxfendazole (5 x 100 mg/kg), or albendazole (5 x 100 mg/kg) when challenged with a. caninum larvae showed 47.77 to 55.81% larval reduction from the challenge dose indicating thereby the development o ... | 1984 | 6491275 |
| population dynamics across selected habitat variables of the helminth community in coyotes, canis latrans, from south texas. | the effects of selected intrinsic variables operating on host subpopulations and of extrinsic variables across the collective host population on the distributions of 10 common helminth species from coyotes in south texas were compared. the intrinsic variables of host sex and presence and severity of sarcoptic mange had little effect on the distributions of most helminth species. the combined influences of (1) seasonal changes across the collective host population and (2) host subpopulations deli ... | 1984 | 6512639 |
| effect of spleen extracts on the immune response in chickens to ancylostoma caninum larvae. | spleen extracts from wlh chickens nonsensitized and sensitized by repeated infections of ancylostoma caninum larvae were injected separately into isologous recipients. extracts from donors infected with repeated high dose (250 + 250 + 500) and low dose (125 + 125 + 250) of larvae induced a significant acquired protective immune response when compared to controls which received normal extracts. no significant difference was observed between the two experimental groups. the filariform ancylostoma ... | 1984 | 6527002 |
| influence of age and sex on susceptibility of dogs to primary infection with ancylostoma caninum. | | 1965 | 5857264 |
| persistence of immunity following double vaccination of pups with x-irradiated ancylostoma caninum larvae. | | 1965 | 5857265 |
| biochemistry of the dog hookworm. i. oxidative metabolism. | | 1965 | 5891649 |
| clinical studies on serum ionic calcium in domestic animals. v. serum ionic calcium in anemic dogs infected with ancylostoma caninum. | | 1963 | 5896546 |
| prevalence of toxocariasis and echinococcosis among dogs in the niger delta. | a sample of 60 dogs in the port harcourt area of the niger delta was examined for intestinal parasites. the high prevalence rates of toxocara canis (56.6%) and echinococcus granulosus (85.0%) in the area are discussed in relation to public health. other parasites found in dogs include toxascaris leonina (3.3%), uncinaria stenocephala (70.0%), dipylidium caninum (88.3%), trichuris vulpis (56.7%), ancylostoma caninum (65.0%) and taenia hydatigenia (43.3%). | 1984 | 6530709 |
| infectivity of ancylostoma caninum in dogs by different routes of inoculation. | infectivity of a. caninum in dogs inoculated with 500 larvae by different routes (percutaneous, subcutaneous, intravenous, per os, through a stomach tube and foot pad) was studied by ascertaining the worm burden at necropsy 21-27 days post-infection. infection through foot-pads yielded the maximum number of worms. the percentage of worm establishment using foot-pad inoculation was 73.8%, followed by subcutaneous (49.0%), percutaneous (45.0%) and per os (35.0%) routes. these results show that act ... | 1984 | 6542725 |
| ancylostoma caninum: a report on the peripheral eosinophilia in naive and immunized swiss albino mice. | the number of peripheral eosinophils was counted in female swiss albino mice on 1, 4, 9, 16 and 30 days after infection with various single (500, 1000 and 2000) and weekly repeated (500 + + 500 + 1000, 1000 + 1000 and 1000 + 1000 + 2000) doses of filariform ancylostoma caninum larvae. the eosinophil response was significantly higher in infected than in uninfected mice and reached a peak on day 16 in naive and day 4 and 9 in immunized mice. immunized mice were significantly more eosinophilic than ... | 1983 | 6662410 |
| endotube-brush border complexes dissected from the intestines of haemonchus contortus and ancylostoma caninum. | a procedure for the blunt dissection of the syncytial intestine of haemonchus contortus to separate the endotube-brush border complex is described. a similar complex can be obtained from the partially cellular intestine of ancylostoma caninum. the structural features of the complexes from the two sources are compared. the main differences are in the retention of terminal bars by the endotube from a. caninum and in the extent and organization of the microfilaments associated with the basal side o ... | 1983 | 6684761 |
| anthelmintic effect of febantel/praziquantel paste in dogs and cats. | a paste formulation of 3.4% febantel and 0.34% praziquantel was given in soft food at a rate of 0.29 g/kg of body weight, once daily for 3 days to dogs and cats. eleven of 12 dogs were naturally infected with ancylostoma caninum, 10 with trichuris vulpis, 2 with toxocara canis, 5 with taenia sp, and 3 with dirofilaria immitis. ten of 11 cats were naturally infected with toxocara cati, 2 with ancylostoma tubaeforme, 3 with taenia sp, 5 with capillaria aerophila, and 1 with paragonimus kellicotti. ... | 1984 | 6703448 |
| rapid expulsion of ancylostoma caninum larvae due to previous infection with hymenolepis nana deshelled eggs. | mice initially infected with single and repeated doses of hymenolepis nana deshelled eggs produced rapid and significant expulsion of challenged ancylostoma caninum larvae. absolute protective response was observed 8 days after initial infection (at 96 hours after challenge) in both singly and repeatedly infected groups probably due to high titres of heterologous reacting antibodies. | 1984 | 6715879 |
| disc electrophoretic studies of hookworms: preliminary comparison of protein fraction in adult necator americanus, ancylostoma duodenale and ancylostoma caninum. | | 1980 | 6780275 |
| the in-vitro interaction between several components of the canine immune system and infective larvae of ancylostoma caninum. | | 1982 | 6811999 |
| transfer of delayed hypersensitivity through repeatedly sensitized peritoneal exudate cells during experimental ancylostomiasis in mice. | current investigations using sensitized peritoneal exudate cells from mice infected repeatedly with ancylostoma caninum larvae supply the evidence that these cells have the capability to transfer passive immunity to isogeneic recipients in contrast to normal cells from uninfected donors. high doses of sensitization to donors and a lapse of time between the expansion and proliferation of cells in the recipients provide a rather strong immunological readiness to expel/destroy the worm burden. the ... | 1983 | 6862315 |
| experimental ancylostomiasis in chickens: effect of various dose of infective ancylostoma caninum larvae on their migration and distribution. | white leghorn chickens, when infected with repeated doses of ancylostoma caninum larvae, expel the larvae at a faster rate than when infected with a single dose. this suggests that the initial dose induces some resistance in the host. an initial dose of 1000 and 2000 larvae, followed by a 2nd dose of the same order, induces resistance in the alimentary tract causing the entire larval burden either to migrate to other tissues (organs) or to be expelled in 24 h. | 1983 | 6873246 |
| determination of the specific gravity of certain helminth eggs using sucrose density gradient centrifugation. | the specific gravities of ten species of helminth eggs were determined using sucrose density gradient centrifugation. fecal or egg concentrate was layered over a 3 to 54% sucrose density gradient. the gradient was then centrifuged at 800 g for 20 min, allowing 5 min for acceleration and 5 for deceleration. bands formed were identified and measured. refractive index was measured at the middle of narrow bands, or at the level at which the concentration of eggs was highest, in the case of wide band ... | 1982 | 6890102 |
| activity of ivermectin against canine intestinal helminths. | the anthelmintic activity of ivermectin was tested in 98 dogs against adult ascarids (toxocara canis, toxascaris leonina), hookworms (ancylostoma caninum, a braziliense), and whipworms (trichuris vulpis), and against experimentally induced infections (4th-stage larvae) of t canis and a caninum. dosage levels tested were single subcutaneous injections of 50, 100, 200, or 400 micrograms/kg of body weight with appropriate vehicle-treated controls. a minimum of 4 (usually 5) dogs were tested with ea ... | 1982 | 6897345 |
| ancylostoma caninum: transfer of lymphoid cells from thymus and bone marrow and adoptive immunity in mice. | | 1982 | 6978858 |
| ancylostoma caninum: immune response to and distribution pattern of larvae in mice with sensitized thymus and bone marrow cells. | suspensions of thymus and bone marrow cells from swiss albino donor mice infected with a. caninum larvae were injected separately or together into syngeneic, nonimmune recipients which were subsequently challenged with the larvae. the transfer of adoptive immunity through these cells has been confirmed and a cooperation and/or complementation between these two types was also observed. these sensitized cells helped the recipients in expelling and/or destroying the challenge larvae more effectivel ... | 1982 | 6982914 |
| [effect of various benzimidazole carbamates on somatic larvae of ancylostoma caninum ercolani 1859 (ancylostomidae) and toxocara canis werner 1892 (anisakidae). 3. immunofluorescent serological studies of antibody levels in treated and untreated dogs]. | | 1981 | 7027683 |
| [effect of various benzimidazole carbamates on somatic larvae of ancylostoma caninum ercolani 1859 (ancylostomidae) and toxocara canis werner 1782 (anisakidae). 1. studies in white mice]. | | 1981 | 7282180 |
| evaluation of granulated fenbendazole as a treatment for helminth infections in dogs. | a granulated formulation of fenbendazole was tested in 95 dogs harbouring naturally occurring infections of toxocara canis, ancylostoma caninum, trichuris vulpis, dipylidium caninum, and taenia spp and in 19 laboratory-reared beagle pups experimentally infected with toxascaris leonina. the drug was administered in moistened dry dog food or in canned dog food. in dosage titration and confirmational studies, using worm counts in naturally infected dogs, the drug was 98%-100% effective at a dosage ... | 1982 | 7056663 |
| pattern of immune response in recipients after transfer of mesenteric lymph node cells sensitized with low and high doses of ancylostoma caninum. | cellular immune response was detected in female swiss albino mice with mesenteric lymph node cells during ancylostoma caninum infection. sensitized lymphocytes responded vigorously to a. caninum antigens and it was found that the cells (singly or repeatedly) sensitized with either low or high doses could confer adoptive protective immunity in recipients later challenged with a single dose of 500 a. caninum larvae. | 1983 | 6629209 |
| pulmonary superoxide dismutase activity in the mouse infected with ancylostoma caninum larvae. | albino mice were infected per os with 1000 infective larvae of ancylostoma caninum and pulmonary superoxide dismutase activity was studied after completion of lung migration. the total superoxide dismutase activity per mg of lung protein was elevated by 15% in infected mice. of the two forms of superoxide dismutases studied, that containing cu-zn was elevated by 44%. this suggests that a. caninum in mice may result in histopathological changes leading to transient pulmonary oxygen toxicity. | 1983 | 6630995 |
| acetylcholinesterase activity in different stages of ancylostoma caninum. | | 1982 | 7147012 |
| ancylostoma caninum: adult worm removal, corticosteroid treatment, and resumed development of arrested larvae in dogs. | | 1982 | 7151941 |
| the effect of ultrafiltrated and dialysed dog serum on the chemotaxis of infective hookworm larvae of ancylostoma caninum. | | 1982 | 7157942 |
| gonadal hormones in experimental ancylostoma caninum infections in male swiss albino mice. | | 1982 | 7160962 |
| gastrointestinal helminth parasites of dogs in the western area--freetown (sierra leone). | a survey of faecal samples taken from 1277 dogs in the western area (freetown, sierra leone) revealed an infestation by ancylostoma caninum (46,1%), toxocara canis (13,5%), toxascaris leonina (5,9%), dipylidium caninum (3,8%), and spirocerca lupi (3,5%). sampling was made per rectum. the age of the dogs examined, both male and female, ranged from one month to fifteen years. the clinical picture of the dogs affected is described and methods of treatment are suggested. | 1982 | 7171367 |
| a comparison of the sites of acid phosphatase activity in an adult filaria, setaria sp. and in some gastro-intestinal nematodes. | the histochemical localization of acid phosphatase in an adult filaria, setaria sp. obtained from the peritoneal cavity of a cow was closely examined and compared with that of adult nematodes parasitic in the host alimentary canal; special attention was paid to the intestine and body wall of the parasites. setaria sp. was found to show high acid phosphatase activity in the interchordal hypodermis of the body wall and uterine microfilariae, and similar activity is suspected to occur in the cuticl ... | 1980 | 7195002 |
| pathogenicity of hookworms. the significance of population regression for the pathogenicity of hookworms. | a method is described to estimate the reduction of the hookworm population in the host during the infection period (population regression). a formula is proposed to estimate the average worm population during the infection period, on the assumption that a decreasing hookworm population causes a decrease in daily blood loss. daily blood loss per worm was calculated for ancylostoma caninum: 43 microliters; for a. ceylanicum: 14 microliters for a. braziliense: 5 microliters. accordingly hookworms ... | 1980 | 7210160 |
| the migratory behaviour and survival pattern of ancylostoma caninum larvae in an adoptively immunised host. | | 1981 | 7228483 |
| pharmacological estimation of histamine in the intestine of mice experimentally infected with repeated doses of ancylostoma caninum larvae. | intestinal extracts from normal [uninfected] and experimental [infected with a repeated dose of 500 + 500 + 1000 ancylostoma caninum larvae] mice were bioassayed for histamine using isolated guinea pig ileum preparation. intestinal histamine level of experimental animals significantly increased on 5th [70 ng] and 30th [75 ng] day after the last stimulating dose of infection. the source of this excess histamine and its role in immunity have been discussed. | 1981 | 7229353 |
| comparative anthelmintic efficacy of two schedules of mebendazole treatment in dogs. | two schedules of anthelmintic oral treatment, using mebendazole powder, were compared in 73 dogs naturally infected with common helminth intestinal parasites. mebendazole powder was administered to 26 dogs at doses of 22 mg/kg once daily for 3 days and was compared with the same dose given only daily for 5 days into 23 dogs. the 24 other dogs were kept as controls and received a placebo treatment for 5 days. efficacy results for the 3-day treatment schedule of mebendazole were as follows: toxoca ... | 1981 | 7271006 |
| effects of temperature and glucose concentration on glycogen synthesis in ancylostoma caninum. | | 1981 | 7275476 |
| the behaviour of infective ancylostoma caninum larvae in serum gradients. | experiments were carried out to investigate if sera of animal species other than dog are chemotactically active for infective larvae of ancyclostoma caninum. those sera were also found to contain such a factor(s), although the larvae were attracted significantly better by dog serum. how this chemotaxis might be applied to the in vivo situation, when infective a. caninum larvae penetrate the skin of dogs, is discussed. | 1981 | 7276506 |
| anthelmintic efficacy of amoscanate (c 9333-go/cgp 4540) against various infections in rodents, dogs and monkeys. | the anthelmintic activity of amoscanate (c 9333-go/cgp 4540) has been studied in experimental infections with the human hookworm, necator americanus, in hamsters; nematospiroides dubius, hymenolepsis nana and natural infections with syphacia obvelata in mice; ancylostoma caninum, a. ceylanicum in mongrel dogs; oesophagostomum apiostumum and strongyloides fuelleborni in rhesus monkeys. single oral doses of 30-60 mg/kg eliminated 94 to 99% of the total necator parasites in 37-day-old non-patent in ... | 1981 | 7283017 |
| gonadectomy and survival of ancylostoma caninum (nematoda) filariform larvae in mice. | gonadectomy reversed the susceptibility response of male and female swiss mice to ancylostoma caninum infection. orchiectomy decreased the survival of filariform larvae (p greater than 0.001 to less than 0.25), whereas ovariectomy increased it significantly (p greater than 0.001 to less than 0.01). | 1982 | 7060717 |
| cloning and characterization of a cdna encoding the catalytic subunit of a camp-dependent protein kinase from ancylostoma caninum third-stage infective larvae. | | 1995 | 7723782 |
| the intestinal helminths of the red fox and some other carnivores in southwest germany. | in south-west germany between 1975 and 1980, 3,573 red foxes (vulpes vulpes), 84 badgers (meles meles), 47 stone martens (martes foina), and 387 cats (felis catus) were examined for intestinal helminths. in foxes the extent of infections was: taenia crassiceps 24%, t. polyacantha 8%, t. taeniaeformis 0.6%, t. serialis 0.5%, mesocestoides leptothylacus 20%, mesocestoides sp. 0.2%, toxocara canis 32%, toxascaris leonina 3%, uncinaria stenocephala 26%. one to three foxes harboured t. hydatigena, t. ... | 1982 | 7072323 |
| investigations into the efficacy of doramectin on reactivated somatic larvae of ancylostoma caninum ercolani 1859 (ancylostomatidae) in pregnant bitches. | the aim of this investigation was to examine whether reactivated somatic ancylostoma caninum larvae can be eliminated by the administration of doramectin to pregnant bitches. four pregnant bitches experimentally infected with 20,000 third-stage larvae of a. caninum were treated subcutaneously with 1 mg doramectin per kg body weight on day 55 of the pregnancy (5-8 days before parturition). another four experimentally infected pregnant bitches served as controls. the single doramectin treatment co ... | 1994 | 7740860 |
| effect of febantel against ancylostoma caninum and trichuris vulpis infections in dogs. | febantel was administered as a 3.4% paste to 45 dogs infected with 1 or more nematode species, which included ancylostoma caninum and trichuris vulpis. dosage levels of 5, 10, or 15 mg/kg of body weight daily for 3 consecutive days for a total of 15, 30, or 45 mg/kg were administered. at 15 mg/kg, all dogs were completely cleared of all nematode and cestode infections, including a caninum, t vulpis, uncinaria stenocephala, toxocara canis, toxascaris leonina, taenia sp, and dipylidium caninum, ex ... | 1982 | 7103181 |
| effect of immunosuppressants in mice: part i--promethazine hydrochloride and hydrocortisone acetate treatments during experimental infections of ancylostoma caninum and nematospiroides dubius. | | 1982 | 7106855 |
| effect of repeatedly sensitized bursal extract on the resistance of wlh chickens to experimental infection of ancylostoma caninum larvae. | | 1982 | 7118369 |
| experimental infection with ancylostoma caninum larvae in mice. vii. role of promethazine hydrochloride in the rejection of worm burden from the intestine. | acquired resistance of female swiss albino mice (6 to 8 weeks old) to ancylostoma caninum infection was demonstrated by the transfer of mesenteric lymph node cells (mlnc) from resistant (sensitised and promethazine treated), sensitised and untreated and non-sensitised and untreated donors to normal recipients of the same isogeneic strain. mlnc from sensitised and promethazine treated donors were more effective in suppressing the rejection mechanism of worm burden in recipients in comparison to t ... | 1982 | 7119431 |
| anthelmintic activity of closantel against ancylostoma caninum in dogs. | the efficacy and minimum therapeutic dose of closantel, an injectable salicylanilide anthelmintic, was evaluated on adult ancylostoma caninum. doses of 7.5 and 10 mg/kg had a marked anthelmintic effect on adult stages, removing 99 and 98%, respectively. a second experiment tested the efficacy of closantel against hypobiotic larval stages of a. caninum. a dose of 20 mg/kg did not affect the abundance of arrested hookworm larvae or prevent their subsequent development, but it may have inhibited th ... | 1982 | 7119989 |
| the function of microtubules during spermatogenesis of ancylostoma caninum. | ancylostoma caninum spermatogonia appeared as unspecialized cells with large nuclei and little cytoplasm when examined by electron microscopy. mitochondria and ribosomes were numerous but endoplasmic reticulum of either the rough or smooth variety was rarely observed. microtubules were abundant but were mostly concentrated in areas where the cells connected with a central cytoplasmic core, or rachis. microtubules present elsewhere in the cytoplasm were not associated with any particular organell ... | 1982 | 7131187 |
| development and fate of the membranous organelles in spermatozoa of ancylostoma caninum. | during development membranous organelles first appeared in the primary spermatocytes of ancylostoma. they were derived from the golgi as two separate components. one component, an electron-dense spheroid, quickly fused with other newly-formed cup-shaped, membranous structures to form the asymmetrical organelles. initially the membranous organelles had a homogeneous matrix but later became filled with quantities to 6- 8-nm filaments. following the meiotic reduction divisions each cell assumed a b ... | 1982 | 7131188 |
| experimental ancylostomiasis in swiss albino mice: adrenal and thyroid histopathology. | remarkable hypertrophic changes were observed in the adrenal and thyroid glands of male mice after 7 to 16 days of infection with the filariform larvae of ancylostoma caninum, but not in females. the adrenal gland revealed enormous enlargement of cells in the zonae glomerulosa, fasciculata and medulla, and also the formation of big vacuoles in the glomerular zone, whereas the thyroid gland showed distinctly hypertrophied follicular epithelium with marked acolloidal condition and follicular mass ... | 1981 | 7310112 |
| [visceral larva migrans caused by ancylostoma caninum]. | | 1981 | 7311953 |
| experimental infection of chickens with ancylostoma caninum: migration and distribution of larvae in tissues. | two hundred one-day-old male white leghorn chickens (gallus domesticus) divided into 4 groups were inoculated with a single dose of 500, 1000, 2000 or 4000 filariform larvae of ancylostoma caninum. larval recoveries were made from different tissues at intervals from 4 hours to 72 hours after infection. larval migration in the heart took place within 4 hours in all the groups except group a with 500 larvae and in thoracic muscle at 8 hours. larvae also migrated into liver, lungs and neck muscle w ... | 1980 | 7410806 |
| scanning electron microscopy of the penetration of newborn mouse skin by strongyloides ratti and ancylostoma caninum larvae. | the scanning electron microscopical appearances of infective larvae of strongyloides ratti and ancylostoma caninum have been described. particularly noteworthy was the tail of s. ratti which was found to have a distal aperture surrounded by a row of eight projections. the penetration of larvae through newborn mouse skin was investigated. s. ratti larvae forced its way rapidly and directly through the stratum corneum. no larvae of a. caninum were observed in stages of partial penetration but the ... | 1980 | 7434072 |
| [helminths of the common fox (vulpes vulpes l.) from the massif central (france) (author's transl)]. | sixty nine wild foxes originating from auvergne for the period january 1977 to january 1978 have shown intestinal parasites in the proportion of 76,8 per cent. 59,4 per cent are invaded with cestodes; 72,4 per cent with nematodes and none with trematodes. the list of the identified species is following: 1. cestodes. a) adults and fertile forms of: mesocestoides litteratus in 27,5 per cent of the hosts; taenia crassiceps in 15,9 p.c.; t. polyacantha in 27,5 p.c.; echinococcus multilocularis in 7, ... | 1980 | 7458165 |
| characterization and localization of cathepsin b proteinases expressed by adult ancylostoma caninum hookworms. | the hookworm ancylostoma caninum induces human eosinophilic enteritis (ee), probably via allergic responses to its secretions. cysteine and metallo-proteinases may be the components of these secretions that elicit hypersensitivity reactions. in order to characterize genes encoding cysteine proteinases (cp) secreted by a. caninum, an adult hookworm cdna library was constructed and screened with a cloned fragment of a hookworm cp gene. this fragment was obtained using consensus oligonucleotide, cp ... | 1995 | 7477098 |
| the a-domain of beta 2 integrin cr3 (cd11b/cd18) is a receptor for the hookworm-derived neutrophil adhesion inhibitor nif. | the a-domain is a approximately 200-amino acid peptide present within structurally diverse proadhesive proteins including seven integrins. a recombinant form of the a-domain of beta 2 integrins cr3 and lfa-1 has been recently shown to bind divalent cations and to contain binding sites for protein ligands that play essential roles in leukocyte trafficking to inflammatory sites, phagocytosis and target cell killing. in this report we demonstrate that the neutrophil adhesion inhibitor, nif produced ... | 1994 | 7528750 |
| neutrophil inhibitory factor prevents neutrophil-dependent lung injury. | neutrophil inhibitory factor (nif) is a recently cloned 41-kda protein from the canine hookworm that binds cd11b/cd18 and inhibits cd11b/cd18-dependent neutrophil adhesion. we evaluated nif's effects on neutrophil-dependent lung injury in guinea pigs. pulmonary vascular endothelial cd54 (icam-1) was induced in buffer-perfused lungs by 90-min exposure to 1000 u/ml tnf-alpha. human neutrophils (2 x 10(7)) were added to the perfusate and activated by 5 x 10(-9) pma; in some lungs, the neutrophils w ... | 1995 | 7594491 |
| ancylostoma caninum anticoagulant peptide: a hookworm-derived inhibitor of human coagulation factor xa. | human hookworm infection is a major cause of gastrointestinal blood loss and iron deficiency anemia, affecting up to one billion people in the developing world. these soil-transmitted helminths cause blood loss during attachment to the intestinal mucosa by lacerating capillaries and ingesting extravasated blood. we have isolated the major anticoagulant used by adult worms to facilitate feeding and exacerbate intestinal blood loss. this 8.7-kda peptide, named the ancylostoma caninum anticoagulant ... | 1995 | 7597095 |
| an investigation into the health status and diseases of wild dogs (lycaon pictus) in the kruger national park. | many factors have been cited as possible reasons for the decline in the number of wild dogs (lycaon pictus), but few studies have provided supportive data. between 1990 and 1993, the dynamics of 10 wild dog packs in the southern district of the kruger national park in south africa were monitored. casual observations of the causes of disease and mortality in the entire population were also recorded. during the same period, 46 wild dogs were immobilised, weighed, and subjected to physical examinat ... | 1995 | 7629782 |
| seasonal influence on human enteric infection by ancylostoma caninum. | ancylostoma caninum, the cosmopolitan canine hookworm prevalent in domestic pets throughout northeastern australia, has been identified as a cause of obscure abdominal pain. to investigate the influence of climate on putative and confirmed human infections, a retrospective study of patients with eosinophilic enteritis and established infections was undertaken to identify the monthly and seasonal rates. the numbers seen each month were maintained throughout most of the year but decreased in june ... | 1995 | 7677217 |
| protective immunity to haemonchus contortus induced by immunoaffinity isolated antigens that share a phylogenetically conserved carbohydrate gut surface epitope. | whole gut homogenates of the blood-sucking nematode haemonchus contortus induce protective immunity in goats, and some of these gut ag are conserved among related parasitic nematode species. to identify gut ag that induce protective immunity and have phylogenetically conserved epitopes, mab were made to gut-surface ag of h. contortus. forty-nine mab reacted with microvilli of the parasite gut. two of these mab (42/10.6.1 and 42/53.3.5) were analyzed here. both of the mab bound to the microvillar ... | 1993 | 7693812 |
| diethylcarbamazine-induced dirofilaria immitis larval death, as indicated by immunoglobulin e concentration, in dogs with concurrent ancylostoma caninum infection. | immunoglobulin e is produced in response to parasitic nematodes that undergo blood and tissue migrations. results of our previous studies indicated that ige and igg respond to dirofilaria immitis in experimentally infected dogs. to determine the association between treatment with the larvicide, diethylcarbamazine (dec), and antibody responses and to examine the potential influence of infection with a nonfilarid intestinal nematode on isotype-specific immune responses, we monitored, by use of iso ... | 1995 | 7717581 |
| [effect of various benzimidazole carbamates on somatic larvae of ancylostoma caninum ercolani 1859 (ancylostomidae) and toxacara canis werner 1782 (anisakidae). 2. studies of pregnant bitches]. | | 1981 | 7293557 |
| the wild dog (lycaon pictus): a new host for ancylostoma caninum. | faecal nematode egg counts performed on one captive and 49 free-ranging wild dogs (lycaon pictus) revealed the presence of eggs of ancylostoma spp. in 12 (24%) of the animals. the captive wild dog pup showed anorexia, general malaise, pale mucous membranes and black stools. adult male and female ancylostoma caninum were recovered from an approximately 3-month-old pup which died of distemper-like disease and a 9-year-old severely debilitated captive wild dog. a single adult a. caninum was also re ... | 1994 | 7745585 |
| comparison of the efficacies of three heartworm preventives against experimentally induced infections with ancylostoma caninum and toxocara canis in pups. | forty 11- to 12-week-old helminth-naive beagles were categorized by sex and weight and randomly assigned to 4 treatment groups (group 1, ivermectin/pyrantel pamoate; group 2, milbemycin oxime; group 3, untreated control; group 4, diethylcarbamazine/oxibendazole). each pup was inoculated po with approximately 100 infective ancylostoma caninum larvae and 100 larvated toxocara canis eggs on day 0, and repeatedly at 7-day intervals thereafter until day 56. administration of anthelmintics also began ... | 1995 | 7782242 |
| [effect of environmental conditions on parasitic infection of dogs]. | the following intestinal parasites: dipylidium caninum, taenia hydatigena, trichocephalus vulpis, ancylostoma caninum, uncinaria stenocephala, toxocara canis, toxascaris leonina, ascaris sp. have been found on the basis of coprological investigations of 120 dogs from the wrocłow shelter, 20 dogs from wrocłow flats and 20 dogs from rural area of kielce district. total extensity of infection of rural dogs was 100% and 40-48% in town. these differences, according to the authors, are connected with ... | 1994 | 7801643 |
| effect of albendazole on ancylostoma caninum larvae migrating in the muscles of mice. | when mice inoculated with 1,000 third-stage larvae of ancylostoma caninum for 1 week were treated intragastrically (ig) with albendazole (alb) 75, 150 or 300 mg/kg.d for 3 days, the mean larva numbers collected from the muscles of each group were 2.7 +/- 1.7, 2.0 +/- 1.5 and 1.0 +/- 1.0, respectively, being much less than that 205 +/- 68 of the control group. in mice treated ig with alb 150 mg/kg.d for 3 days, the concentrations of alb and its effective metabolite, albendazole sulfoxide (albso), ... | 1994 | 7867159 |
| eosinophilic enteritis in northeastern australia. pathology, association with ancylostoma caninum, and implications. | while eosinophilic gastroenteritis is considered a rare condition, eosinophilic enteritis without gastric involvement is quite common in northeastern australia. we present 79 patients with biopsy-proven eosinophilic enteritis, 70 seen since 1987. in 10 patients, eosinophilic enteritis was associated with infection by single, sexually immature, adult hookworms, most positively identified as the common dog hookworm ancylostoma caninum. an additional 22 patients (of 34 tested) had serological evide ... | 1995 | 7872431 |
| dog hookworm: a cause of eosinophilic enterocolitis in humans. | | 1994 | 7877002 |
| abdominal pain, pan-gut eosinophilia, and dog hookworm infection. | | 1995 | 8583307 |
| ancylostoma caninum: immunization through transfer of sensitized lymphoid cells & their effect on the expulsion and/or destruction of worm burden in swiss albino mice. | | 1981 | 7309160 |
| the influence of thyroxine on the host-parasite relationship of ancylostoma caninum in swiss albino mice. | | 1981 | 7309337 |
| hyaluronidases of the gastrointestinal invasive nematodes ancylostoma caninum and anisakis simplex: possible functions in the pathogenesis of human zoonoses. | the gastrointestinal invasive stages of two parasitic nematodes, ancylostoma caninum and anisakis simplex, were each found to release in vitro a hydrolytic enzyme that degrades the glycosaminoglycan hyaluronic acid. the parasite hyaluronidases were partially purified by ion-exchange chromatography and biochemically characterized. the hyaluronidase from a. caninum adult worms had a molecular weight of 65,000 and a ph optimum of 6 with activity at neutral ph, while the hyaluronidase from a. simple ... | 1994 | 7930737 |
| secretion of cysteine proteinase activity by the zoonotic hookworm ancylostoma caninum. | the zoonotic hookworm, ancylostoma caninum, probably induces human eosinophilic enteritis by inducing allergic responses to its secretions. this species is already known to secrete metalloproteinases, but in other parasites, cysteine proteinases are involved in pathogenesis. we studied somatic extracts of a. caninum adults and infective larvae and adult excretory/secretory (es) antigens for cysteine proteinase activity using fluorogenic peptide substrates and by gelatin and fluorogenic substrate ... | 1994 | 7943555 |
| efficacy of fenbendazole against giardiasis in dogs. | efficacy of fenbendazole at 2 dosages for treating naturally acquired giardiasis in dogs was assessed. giardia cysts were not detected in the feces of 6 of 6 group-1 dogs (as determined by use of the zinc sulfate concentration technique) after fenbendazole treatment (50 mg/kg of body weight, po, q 24 h, for 3 doses). cysts were not detected in the feces of 6 of 6 group-2 dogs after fenbendazole treatment (50 mg/kg of body weight, po, q 8 h, for 3 days). however, cysts were not detected in the fe ... | 1994 | 7978640 |
| intestinal helminth parasite community in wolves (canis lupus) in italy. | from 1987 to 1993, 89 wolves (canis lupus) collected throughout the whole italian range were examined for intestinal helminth parasites. twelve species were found, including 5 nematodes (uncinaria stenocephala, toxocara canis, ancylostoma caninum, trichuris vulpis and toxascaris leonina) and 7 cestodes (echinococcus granulosus, taenia hydatigena, t. multiceps, t. pisiformis, t. ovis, mesocestoides lineatus and dipylidium caninum). no significant differences were detected between sexes. t. canis ... | 1993 | 8065823 |
| intestinal helminths of public health importance in dogs in nairobi. | in a survey of intestinal canine zoonotic helminths in nairobi, 156 dogs were autopsied. of these, 10% were infected with echinococcus granulosus, 88% with ancylostoma caninum, 45% with dipylidium caninum and 3% with toxocara canis. all the infected dogs with e. granulosus originated from around abottoirs in dagoretti. the risk of infection in man with hydatid disease is considered to be high around dagoretti and control measures are recommended. | 1993 | 8187655 |
| ancylostoma caninum: glutathione stimulates feeding in third-stage larvae by a sulfhydryl-independent mechanism. | the reduced form of the tripeptide glutathione has been reported to reinitiate feeding by third-stage larvae of the hookworm ancylostoma caninum. investigations were conducted with the gsh analogue ophthalmic acid to determine the mechanism by which gsh stimulates feeding. ophthalmic acid stimulated feeding, beginning at 1-2.5 mm and reaching a maximum by 10-15 mm, and also enhanced serum-stimulated feeding. the results indicate that gsh stimulates feeding by a specific, sulfhydryl-independent m ... | 1993 | 8253162 |
| occult enteric infection by ancylostoma caninum: a previously unrecognized zoonosis. | human disease caused by the canine hookworm ancylostoma caninum and a high incidence of eosinophilic enteritis have been reported from northern queensland, australia. the aim of this study was to evaluate patients with unexplained abdominal pain and a possible association with cryptic infections by a. caninum. | 1994 | 8276205 |
| immunologic incrimination of ancylostoma caninum as a human enteric pathogen. | in northeastern australia, the incidence of human eosinophilic enteritis (ee) and unexplained abdominal pain with peripheral blood eosinophilia (pe) appear to be exceptionally high. because adults of the common dog hookworm, ancylostoma caninum, were found in situ in several cases, we compared specific antibody responses in patients with ee or pe with those of individuals from various control groups. sera were obtained from three patients with confirmed dog hookworm infection, 25 patients with e ... | 1994 | 8304575 |
| human enteric infection with canine hookworms. | to describe a zoonotic ancylostomiasis (canine), acquired from domestic pets by patients living in developed, urban communities. | 1994 | 8304653 |
| the ecology of animal parasitic nematodes in endemic areas of jos, nigeria. | a survey involving 3418 faecal samples collected from three areas of heavy human and animal activities in jos, nigeria showed that 2354 (68.9%) of the samples harboured various parasitic nematodes of man and animals. altogether, twelve species of parasitic nematodes were encountered. five of these, namely: ascaris lumbricoides, ancylostoma duodenale, necator americanus, trichuris trichiura and strongyloides stercoralis infect man while five others: trichostrongylus probolurus, t. colubriformis, ... | 1993 | 8334456 |
| efficacy of ivermectin in a beef-based chewable formulation against ancylostoma caninum and uncinaria stenocephala in dogs. | the effective dosage of a chewable formulation of ivermectin was determined in 35 young dogs with induced infections of ancylostoma caninum and uncinaria stenocephala. dogs were inoculated with these parasites and held until the infections were patent. within each of 7 replicates, dogs were allocated randomly to 1 of 5 treatment groups: vehicle control, or ivermectin at 6, 12, 18, or 24 micrograms/kg. chewable treatments were tailored to body weight. seven or 8 days after treatment, parasites we ... | 1993 | 8410551 |
| immunohistochemical localization of excretory/secretory antigens in adult ancylostoma caninum using monoclonal antibodies and infected human sera. | human eosinophilic enteritis (ee) may result from hypersensitivity to the excretory/secretory (es) antigens of adult ancylostoma caninum. the origin of several antigens were identified by probing adult a. caninum with mouse monoclonal antibodies (moabs), sera from mice vaccinated with es antigens and sera from human ee patients. six moabs (ac/es 1-6) were produced against es antigens, two being igg3 and four igm. western blots demonstrated four different antigen specificities: moab ac/es 1 bound ... | 1995 | 7731733 |
| ancylostoma caninum: metalloprotease release coincides with activation of infective larvae in vitro. | infective stages of several nematode parasites are known to release proteases in excretory/secretory products. these enzymes are believed to facilitate tissue invasion, although direct evidence is lacking. for these investigations, we employed an assay that uses the resumption of feeding as a marker for early events in the infectious process. when ancylostoma caninum third-stage infective larvae are stimulated to feed in vitro, they release proteases of approximately 50,000 and 90,000 molecular ... | 1995 | 7895832 |
| functional interaction between the integrin antagonist neutrophil inhibitory factor and the i domain of cd11b/cd18. | neutrophil inhibitory factor (nif) is a hookworm-derived glycoprotein ligand of the integrin cd11b/cd18 that inhibits human neutrophil function (moyle, m., foster, d. l., mcgrath, d. e., brown, s. m., laroche, y., de meutter, j., stanssens, p., bogowitz, c. a., fried, v. a., ely, j. a., soule, h. r., and vlasuk, g. p. (1994) j. biol. chem. 269, 1008-10015). here, we present evidence that recombinant nif (rnif) associates with the approximately 200-amino acid residue i domain of cd11b/cd18 and th ... | 1994 | 7929363 |
| cloning and characterization of ancylostoma-secreted protein. a novel protein associated with the transition to parasitism by infective hookworm larvae. | the developmentally arrested third stage infective larva of hookworms resumes development upon entry into the definitive host. this transition to parasitism can be modeled in vitro by stimulating infective larvae with a low molecular weight ultrafiltrate of host serum together with methylated glutathione analogues. when stimulated to resume development in vitro, activated larvae of the hookworm ancylostoma caninum released a 42-kda protein, termed ancylostoma-secreted protein (asp). asp was the ... | 1996 | 8636085 |
| observations on the feeding behaviour of parasitic third-stage hookworm larvae. | the feeding behaviour of parasitic 3rd-stage larvae (l3) of the hookworms ancylostoma caninum, a. ceylanicum and necator americanus was examined. less than 11% of a. caninum l3 recovered from the small intestines of dogs infected orally were feeding at 4-48 h post-infection (p.i.), and none of the a. ceylanicum l3 recovered from the intestines of orally infected hamsters had resumed feeding. all l4 of both species recovered at 36 and 48 h p.i. had resumed feeding. on the other hand, approximatel ... | 1993 | 8446471 |
| the prevalence of giardia and other intestinal parasites in children, dogs and cats from aboriginal communities in the kimberley. | to determine the prevalence of giardia duodenalis and other intestinal parasites in children, dogs and cats from aboriginal communities in the west kimberley region of western australia. | 1993 | 8450779 |
| a field and laboratory evaluation of a commercial elisa for the detection of giardia coproantigens in humans and dogs. | a capture enzyme linked immunosorbent assay (celisa) was evaluated for its ability to detect giardia coproantigens in the faeces of humans and dogs in the perth metropolitan area and aboriginal communities in fitzroy crossing, western australia. using zinc sulphate flotation and light microscopy, giardia cysts and/or trophozoites were observed in 8 of 57 (14%) human stool samples from perth and 21 of 55 (38%) stool samples from fitzroy crossing, after 2 separate examinations. analysis of diagnos ... | 1993 | 8465392 |
| persistence of a recurrent group of intestinal helminth species in a coyote population from southern texas. | the persistence and interrelationships of a recurrent group of intestinal helminth species in a coyote population from southern texas were determined; data were collected at 4-yr intervals (1979, 1983, and 1987). the a priori expectation was that a defined recurrent group of helminth species persisted over time and that the respective helminth species were stable in terms of their abundances. the fager index and subsequent recurrent group analysis indicated a small group of taxonomically unrelat ... | 1993 | 8501593 |
| amplification and characterization of cysteine proteinase genes from nematodes. | in order to isolate proteinase genes from parasitic nematodes by polymerase chain reaction (pcr) techniques, we employed a pair of consensus oligonucleotide primers designed to anneal to the active site cysteine (primer ncpc) and asparagine (primer ncpn) coding regions of cysteine proteinases. the primers were biased toward the nucleotide and codon usages of cysteine proteinase genes of nematodes and were based on the consensus nucleotide sequences flanking the active site residues of genes from ... | 1995 | 8525283 |
| neutrophil inhibitory factor is neuroprotective after focal ischemia in rats. | we tested the neuroprotective potential of neutrophil inhibitory factor (rnif), a novel 41-kd recombinant glycoprotein derived from a hookworm, in a model of focal cerebral ischemia in the rat. male wistar rats were assigned to treatment with rnif and vehicle. middle cerebral artery occlusion (mcao) for 2 hours was induced by insertion of an intraluminal suture. infusion of the drug was initiated at the onset of reperfusion. infarct volume was determined 48 hours after reperfusion. neutrophils w ... | 1995 | 8526467 |
| a natural glycoprotein inhibitor (nif) of cd11b/cd18 reduces leukocyte adhesion in the liver after hemorrhagic shock. | this study was designed to assess the effect of neutrophil inhibitory factor (nif), a novel specific inhibitor of cd11b/cd18 on hepatic leukocyte trafficking by intravital microscopy 5 h after hemorrhagic shock. anesthetized rats were instrumented for invasive hemodynamical monitoring. hemorrhagic shock was induced for 60 min by withdrawal of arterial blood (mean arterial blood pressure = 40 mmhg). rats were adequately resuscitated for 5 h to achieve a mean arterial blood pressure > 100 mmhg and ... | 1995 | 8574753 |
| new anticoagulant prompts bad blood between partners. | | 1996 | 8596945 |
| a hookworm glycoprotein that inhibits neutrophil function is a ligand of the integrin cd11b/cd18. | the chronic survival of many endoparasites is dependent on the ability of these organisms to escape the host immune response. identification of the molecular mechanisms by which these organisms evade this response may yield novel approaches in the development of anti-inflammatory agents. we describe here the discovery and characterization of a novel 41-kilodalton glycoprotein from the canine hookwork (ancylostoma caninum) that potently inhibits cd11/cd18-dependent neutrophil function in vitro. n ... | 1994 | 7908286 |
| the role of cd11/cd18 integrins in the reverse passive arthus reaction in rat dermal tissue. | the cd11/cd18 leukocyte integrins are necessary for tissue localization of neutrophils, an early requisite event in inflammation. we have analyzed the contribution of cd11a/cd18 and cd11b/cd18 to local neutrophil accumulation and tissue injury in the reverse passive arthus reaction in the rat dermis. experimental groups comprised animals that received an intravenous infusion of (1) recombinant neutrophil inhibitory factor (nif), a hookworm-derived antagonist of cd11b/cd18; (2) monoclonal antibod ... | 1996 | 8603998 |
| attenuation of the inflammatory response in an animal colitis model by neutrophil inhibitory factor, a novel beta 2-integrin antagonist. | neutrophils are significant effector cells in acute inflammatory bowel disease. recruitment of these cells is dependent on beta 2-integrin-mediated adhesion and transmigration. the efficacy of neutrophil inhibitory factor (nif), an antagonist of the beta 2-integrin cd11b/cd18, in ameliorating inflammation was tested in an animal model of acute colitis. | 1996 | 8858748 |