Publications

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nmr-based structural analysis of the complete rough-type lipopolysaccharide isolated from capnocytophaga canimorsus. 201526475523
[capnocytophaga canimorsus: a cause of multi-organ failure accompanied by livedo]. 201728549666
capnocytophaga canimorsus - an underestimated cause of periprosthetic joint infection?periprosthetic joint infection (pji) is a major clinical problem in orthopedic surgery. capnocytophaga canimorsus (c. canimorsus) is an unusual and hardly detectable bacterium. a review of the literature indicates that c. canimorsus affects mainly immunocompromised patients. it has not been reported to cause periprosthetic joint infections in immunocompetent patients so far. this case report aims to raise awareness of c. canimorsus in orthopedic surgery with special regard to joint arthroplasty.201728526202
  201728443707
a small 'lick' will sink a great ship: fulminant septicaemia after dog saliva wound treatment in an asplenic patient.capnocytophaga canimorsus is a bacterium transmitted through the saliva of dogs. an infection can cause severe sepsis with acral necrosis and is potentially fatal. here, we report the case of a 41-year-old man who was infected through a wound that was licked by his dog. he went into septic shock with disseminated intravascular coagulation and subsequently lost both lower legs, his nose and all the fingers on both hands.201728425162
only a subset of c. canimorsus strains is dangerous for humans.capnocytophaga canimorsus are gram-negative bacteria living as commensals in the mouth of dogs and cats. c. canimorsus cause rare but life-threatening generalized infections in humans that have been in contact with a dog or a cat. over the last years we collected 105 c. canimorsus strains from different geographical origins and from severe human infections or healthy dogs. all these strains were analyzed by 16s rdna sequencing and a phylogenetic tree revealed two main groups of bacteria instead ...201526421271
rapid killing of capnocytophaga canimorsus and capnocytophaga cynodegmi by human whole blood and serum is mediated via the complement system.capnocytophaga canimorsus (cani) and capnocytophaga cynodegmi (cyno) are found in the oral cavities of dogs and cats. they can be transmitted to humans via licks or bites and cause wound infections as well as severe systemic infections. cani is considered to be more pathogenic than cyno, but the pathophysiological mechanisms are not elucidated. cani has been suggested to be resistant to serum bactericidal effects. thus, we hypothesized that the more invasive cani would exhibit a higher degree of ...201526405637
diseases transmitted by man's best friend: the dog.the relationship between dogs and humans is ancient and mutually beneficial. dogs have served people well as companions, workmates, guides, and protectors. however, on occasion, dogs may injure humans through biting or may transmit pathogens resulting in a large number of problems ranging from a trivial rash to life-threatening bacteremia. given that there are more than 80 million pet dogs in the united states, it is worth knowing the potential problems that can result from canine exposure. annu ...201526350317
distribution of capnocytophaga canimorsus in dogs and cats with genetic characterization of isolates.capnocytophaga canimorsus, which is often found in the oral cavities of dogs and cats, is sometimes transmitted to humans, causing severe infection. to elucidate the risk of c. canimorsus in humans and animals, this study was undertaken to characterize this bacterium epidemiologically and genetically. we examined the distribution of c. canimorsus in dogs and cats, and analyzed the correlation between the presence of bacteria and individual factors statistically. we also compared c. canimorsus is ...201424745627
renal failure due to capnocytophaga canimorsus generalized shwartzman reaction from a dog bite (df-2 nephropathy).we report a case of a 54-year-old man who developed gram-negative sepsis with multiorgan failure and generalized shwartzman reaction after sustaining a dog bite. the causative organism was the fastidious gram-negative rod capnocytophaga canimorsus, which is a commensal organism found in the oral flora of dogs and cats. more than 30 years after it was first described and despite technological advances in identification techniques, proper identification of this organism remains a challenge. in lig ...201424688203
[fulminant sepsis due to capnocytophaga canimorsus: diagnosis by matrix-assisted laser desorption/ionization-time of flight mass spectrometry]. 201424103212
capnocytophaga canimorsus sepsis following bmt in a patient with aml: possible association with functional asplenia. 201423974607
draft genome sequences of three capnocytophaga cynodegmi strains isolated from the oral cavity of healthy dogs.here, we present the draft genome sequences of three strains of capnocytophaga cynodegmi. in contrast to the very close relationship among them, c. cynodegmi and capnocytophaga canimorsus differ dramatically in terms of virulence in humans. comparative genomics provided some understanding on how capnocytophaga species may switch from being dog commensals to human pathogens.201526021913
draft genome sequences of three capnocytophaga canimorsus strains isolated from healthy canine oral cavities.here, we present the draft genome sequences of three strains of capnocytophaga canimorsus, each isolated from a different dog's mouth. genome analysis provided evidence that these organisms may belong to a different nonpathogenic subtype of c. canimorsus.201526021912
draft genome sequences of three capnocytophaga canimorsus strains isolated from septic patients.capnocytophaga canimorsus is a bacterium from the normal oral flora of dogs and cats that causes rare generalized infections in humans. in an attempt to determine whether infections could be caused by a subset of strains and to identify pathogenicity factors, we sequenced the genomes of three strains isolated from human infections.201526021910
capnocytophaga canimorsus: an emerging cause of sepsis, meningitis, and post-splenectomy infection after dog bites.newly named in 1989, capnocytophaga canimorsus is a bacterial pathogen found in the saliva of healthy dogs and cats, and is transmitted to humans principally by dog bites. this review compiled all laboratory-confirmed cases, animal sources, and virulence attributes to describe its epidemiology, clinical features, and pathogenesis. an estimated 484 patients with a median age of 55 years were reported, two-thirds of which were male. the case-fatality rate was about 26%. its clinical presentations ...201525828064
glycan-foraging systems reveal the adaptation of capnocytophaga canimorsus to the dog mouth.capnocytophaga canimorsus is known to form two kinds of cells on blood agar plates (coccoid and bacillary), evoking phase variation. when grown in coculture with animal cells these bacteria appeared only as bacilli, but in the presence of vancomycin they were round, indicating that coccoid shapes likely result from weakening of the peptidoglycan layer. polysaccharide utilization locus 5 (pul5) and sialidase mutant bacteria, unable to retrieve glycans from glycoproteins, grew less than wild-type ...201525736888
acute generalized livedo racemosa caused by capnocytophaga canimorsus identified by maldi-tof ms.independent of the size of the dog and the type of injury, serious infections may follow a dog bite and these may result in the abrupt onset of multiorgan failure. early recognition of the warning signs with regard to the underlying severity of the infection is of the utmost importance. reticulate skin eruptions constitute a precursory phenomenon.201525677725
a rare case of waterhouse-friderichsen syndrome caused by capnocytophaga canimorsus in an immunocompetent patient.a 53-year-old caucasian male with hypertension and active tobacco abuse presented to a community hospital with a 2-day history of vague abdominal pain, myalgia and increased lethargy after being bitten on his right hand by the family dog while camping just 3 days prior to symptom onset. he expired within 90 min upon arrival to our intensive care unit. pre-mortem blood cultures grew a fastidious gram-negative aerobic rod that was identified as capnocytophaga canimorsus. autopsy findings showed mu ...201525676131
capnocytophaga canimorsus bacteremia presenting with acute cholecystitis after a dog bite.capnocytophaga canimorsus is part of normal gingival flora of dogs and cats. the organism can cause septicemia, meningitis, and endocarditis in humans after contact with dogs or cats. in spite of the frequency of gastrointestinal symptoms in c. canimorsus infection patients, specific gastrointestinal disease or clinical images have not been reported. we report a case of c. canimorsus bacteremia presenting with acute cholecystitis in elderly woman. she suffered from general fatigue and right uppe ...201525445385
a case of capnocytophaga canimorsus sacral abscess in an immunocompetent patient.we report a unique case of sacral capnocytophaga canimorsus abscess successfully treated with surgery and antibiotics. close contact to a dog was assumed to be the most likely source of infection. established risk factors for invasive c. canimorsus infection such as splenectomy, alcoholism or overt immunosuppression could not be identified. the role of cigarette smoking, portal of entry and the possible relevance of altered skin microbiota as well as the diagnostic value of polymerase chain reac ...201525182960
hypertensive emergency and type 2 myocardial infarction resulting from pheochromocytoma and concurrent capnocytophaga canimorsus infection.a diagnosis of myocardial infarction is made using a combination of clinical presentation, electrocardiogram and cardiac biomarkers. however, myocardial infarction can be caused by factors other than coronary artery plaque rupture and thrombosis. we describe an interesting case presenting with hypertensive emergency and type 2 myocardial infarction resulting from pheochromocytoma associated with capnocytophaga canimorsus infection from a dog bite. we also review current literature on the managem ...201425024773
facial purpura associated with capnocytophaga canimorsus septicaemia; role of sunlight? 201423816547
capnocytophaga canimorsus infection in cats: abcd guidelines on prevention and management.capnocytophaga canimorsus and capnocytophaga cynodegmi are part of the normal bacterial flora of the oral cavity of dogs and cats. c canimorsus is more pathogenic and causes more severe infections in humans.201323813822
two dog-related infections leading to death: overwhelming capnocytophaga canimorsus sepsis in a patient with cystic echinococcosis.capnocytophaga canimorsus is a fastidious, capnophilic, fusiform, and filamentous gram-negative rod. it is part of the normal oral flora of dogs and cats and can cause an infection in humans, but is of generally low virulence in healthy individuals. a case of fatal sepsis due to capnocytophaga canimorsus in a 46-year-old woman with clinically silent cystic echinococcosis discovered postmortem is present. she had been bitten by a dog 3 days before the symptoms appeared. the family had owned the d ...201222491382
identification of blood and wound isolates of c. canimorsus and c. cynodegmi using vitek2 and maldi-tof.capnocytophaga canimorsus and c. cynodegmi are gram negative bacteria that can be transmitted to humans from dogs or cats and cause serious infections. routine bacteriological methods, including fermentation and phenotypic tests are insufficient to correctly identify c. canimorsus or c. cynodegmi. the aim of this study was to evaluate the performance of vitek2 and maldi-tof in identification of these bacteria. twenty two isolates that were identified as c. canimorsus / c. cynodegmi by 16s rrna s ...201222454088
[capnocytophaga canimorsus meningitis diagnosed by means of a 16s rrna analysis].capnocytophaga canimorsus is a gram-negative bacterial species hosted in the oral cavity of dogs. c. canimorsus can cause sepsis, meningitis and endocarditis. penicillin is the drug of choice. however, the species is a slow-grower and sometimes missed in blood cultures. patients with a history of alcoholism, splenectomy or immunodeficiency are at an increased risk of contracting serious infections with c. canimorsus following dog bites. we report a case story of c. canimorsus meningitis contract ...201222293076
three cases of capnocytophaga canimorsus meningitis seen at a regional hospital in one year.three cases of meningitis caused by the fastidious gram-negative rod capnocytophaga canimorsus have been observed at a regional hospital in 1 y. the difficulties connected with the correct diagnosis by classical culturing methods in contrast to molecular methods, as well as possible reasons for the accumulation of cases, are discussed.201222292539
cave canem: hbo₂ therapy efficacy on capnocytophaga canimorsus infections: a case series.dog bites are a frequent injury, but the incidence and type of lesions vary across countries. although only few patients develop complications, the treatment of advanced injuries has a considerable medical, social and economic impact. a frequently isolated pathogen in dog bite wounds is capnocytophaga canimorsus, a bacterium that can cause sepsis or meningitis. hyperbaric oxygen (hbo₂) therapy has been shown to be useful in treating anaerobic infections, most likely because it creates an inhospi ...201728777909
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