| gene organization of the transforming region of weakly oncogenic adenovirus type 7: the e1a region. | the structures of adenovirus type 7 (ad7) cytoplasmic rnas transcribed from the leftmost 4.5% of the viral genome during lytic infection of kb cells have been determined. the e1a region was found to specify three differently spliced mrnas (i, ii and iii) which have common 5' and 3' termini. mrnas i and ii are transcribed between identical initiation and termination codons and code for polypeptides of 28 kd and 24 kd, whose only difference is an internal sequence of 32 amino acids present in the ... | 1980 | 6985480 |
| restricted replication of mouse adenovirus strain fl in mouse balb/c cells transformed by simian adenovirus 7. | | 1982 | 7064348 |
| cytologic detection of virus-specific dna by in situ hybridization in syrian hamster embryo cells transformed by viral or combined chemical and viral treatment. | a series of simian adenovirus 7 (sa7)-transformed syrian hamster cell lines that had t antigen and produced tumors in neonatal hamsters were examined by radioautography in conjunction with in situ molecular hybridization to determine the extent to which the viral genome is integrated on specific chromosomes and the consequences of such integration on sister chromatid exchange (sce) frequency. no consistent cytological or chromosomal localization of viral dna in situ hybridization with viral comp ... | 1982 | 7151038 |
| a sixth species of ovine adenovirus isolated from lambs in new zealand. | two adenoviruses (wv419/75 and wv757/75), isolated from lambs in new zealand were compared using neutralisation tests with the five recognised ovine adenovirus species, nine bovine and four porcine adenoviruses. wv419/75 did not cross-react with any of the viruses tested and represents a new ovine adenovirus species (oav-6). wv757/75 cross-reacted with bovine adenovirus type 7 (bav-7) with a homologous to heterologous titre ratio of 16 in one direction only, and also showed a substantial one-way ... | 1982 | 7165512 |
| [peptide mapping of the hexon and internal protein of type 6 human and type 7 simian adenoviruses]. | hexons (polypeptide 11) and core proteins (polypeptide v) of human adenovirus type 6 and simian adenovirus type 7 were isolated using electrophoresis in polyacrylamide gel. tryptic peptide maps showed the similarity but not identify in the structure of proteins studied. this method seems to be the most suitable for comparison of relative viral proteins. | 1981 | 7248505 |
| a nonessential glycoprotein is coded by early region e3 of adenovirus type 7. | | 1981 | 7257191 |
| the distribution of guanine-cytosine pairs in adenovirus dnas. | the distribution of guanine-cytosine (gc) pairs in the dna of the highly oncogenic simian adenovirus type 7 (sa7) and the non-oncogenic human adenovirus type 6 (ad6) has been studied by thermal denaturation and csc1 density-gradient centrifugation. the differential of the dna thermal denaturation curves shows the presence of pronounced peaks which indicates uneven distribution of gc pairs along the dna chains and the presence of regions with gc content from 30 to 74% in sa7 dna and from 40 to 68 ... | 1981 | 7288411 |
| restriction endonuclease analysis of bovine herpesvirus type 1 isolates from calves with fatal encephalitis: comparison with vaccine virus. | meningo-encephalitis in feedlot cattle sporadically occurred in the tokachi area in northern japan. the calves had been vaccinated intranasally with a mixed live-vaccine (infectious bovine rhinotracheitis virus, bovine viral diarrhea-mucosal disease virus, and parainfluenza 3 virus) for which intramuscular inoculation was indicated. two additional live vaccines, bovine adenovirus type 7 and bovine respiratory syncytical virus, had been inoculated simultaneously. eleven isolates of bovine herpesv ... | 1995 | 7548427 |
| construction and characterization of adenovirus co-expressing hepatitis b virus surface antigen and interleukin-6. | coexpression of biologically active interleukin 6 (il-6), an immunoregulator, and hepatitis b virus surface antigen (hbsag), an immunogen, was obtained using an adenovirus type 7 (ad7) vector. two recombinant adenoviruses (re-ad) containing both the hbsag and il6 genes were constructed: one virus was capable of expressing il6 with its signal peptide (spil6) (ad7::spil6::hbsag), and the second virus lacked this sequence (ad7::il6::hbsag). a third recombinant contained only hbsag (ad7::hbsag). all ... | 1994 | 8125296 |
| [the genomic variability of adenovirus serotype 7]. | genetic heterogeneity and evolutionary relationships among selected strains of adenovirus type 7 (ad7) isolated in the former ussr were examined using the restriction endonuclease cfr131 with a 4-base recognition cleavage site. the population of adenovirus type 7 showed less expressed genome polymorphism and significant structural distinctions as compared with that of adenovirus type 3. the ad7 evolution in the ussr (1976-1988) independent on that demonstrated in other countries is discussed. | 1994 | 8160439 |
| isolation and characterization of adenovirus-associated va rnas of human adenovirus type 7. | two genes for virus-associated va rnas in the human adenovirus type 7 (ad7) genome are compared to ad2, ad4, ad5, simian va rnas, and pol iii transcripts of epstein-barr virus. the newly identified va rna-encoding genes of ad7 contain two relatively conserved intragenic promoter (elements a and b), the double-stranded rna-dependent protein kinase (pk) active site-binding domain and transcriptional terminators. the conserved features extend to the va rna genes of simian and avian origin. | 1994 | 8194770 |
| sequence and functional analysis of the human adenovirus type 7 e3-gp19k protein from 17 clinical isolates. | the adenovirus (ad) early region 3 (e3) glycoprotein of 19k (gp19k) binds major histocompatibility (mhc) class i antigens in the endoplasmic reticulum (er), and the gp19k-class i complex is retained in the er through an er retention signal at the c-terminus of gp19k. this retention of class i antigens blocks cytolysis of gp19k-expressing cells by cytotoxic t lymphocytes (ctl). animal models infected with ad mutants lacking gp19k support a role for gp19k in counteracting a ctl response. gp19k bin ... | 1993 | 8249282 |
| constructing chimeric type 12/type 5 adenovirus e1a genes and using them to identify an oncogenic determinant of adenovirus type 12. | the e1a gene of highly oncogenic type 12 adenovirus (ad12) possesses a segment unique to this serotype and comprising 60 base pairs contiguous with and separating conserved regions 2 and 3 in the gene. a similar but slightly longer segment is also present in the e1a gene of highly oncogenic simian adenovirus type 7 (d. kimelman, j. s. miller, d. porter, and b. e. roberts, j. virol. 53:399-409, 1985). this segment is missing entirely from the e1a gene of type 5 adenovirus, which is nononcogenic. ... | 1994 | 8289390 |
| tumorigenicity of adenovirus-transformed rodent cells is influenced by at least two regions of adenovirus type 12 early region 1a. | chimeric adenovirus type 5 (ad5)/ad12 early region 1a (e1a) genes were used to transform primary baby rat kidney cells in cooperation with ad12 e1b, and the resulting cell lines were assayed for tumorigenicity in syngeneic rats. it was found that lines were nontumorigenic when transformed by hybrid e1a genes consisting of the amino-terminal 80 amino acids from ad12 including conserved region 1 (cr1), with the remaining portion from ad5. in contrast, cell lines transformed by hybrids containing a ... | 1994 | 8289391 |
| effect of heparin on hemagglutination by pseudorabies virus. | heparin inhibited hemagglutination (ha) by pseudorabies virus (prv), but not ha by akabane virus, bovine adenovirus type 7, fukuoka virus, getah virus, japanese encephalitis virus, and parainfluenza virus type 3 belonging to the families bunyaviridae, adenoviridae, rhabdoviridae, togaviridae, flavivi-idae, and paramyxoviridae, respectively. the minimal inhibitory concentration of heparin required to inhibit 8 ha u of prv ranged from 0.005 to 0.01 u/ml. mouse erythrocytes failed to combine with t ... | 1993 | 8381261 |
| comparative analysis of the structure and function of adenovirus virus-associated rnas. | the protein kinase dai is an important component of the interferon-induced cellular defense mechanism. in cells infected by adenovirus type 2 (ad2), activation of the kinase is prevented by the synthesis of a small, highly ordered virus-associated (va) rna, va rnai. the inhibitory function of this rna depends on its structure, which has been partially elucidated by a combination of mutagenesis and rnase sensitivity analysis. to gain further insight into the structure and function of this regulat ... | 1993 | 8411363 |
| [a 12-year-old girl with acute respiratory disease with pneumonia caused by adenovirus type 7]. | we have encountered a 12-year-old girl with acute respiratory disease including pneumonia caused by adenovirus type 7. while being followed-up for bronchial asthma, she developed this disease with dyspnea accompanied by high fever, pharyngalgia and a dry cough subsequent to a slight fever. adenovirus type 7 was separated and identified from the pharyngeal smear. additionally, perfusion scintigraphy of the lungs presented evidence of interstitial pneumonia. with these findings and the clinical co ... | 1996 | 8699100 |
| isolation of adenovirus type 7 from the urine of children with acute hemorrhagic cystitis. | | 1996 | 8823863 |
| hexon sequence of adenovirus type 7 and comparison with other serotypes of subgenus b. | the hexon gene of human adenovirus (av) type 7 (subgenus b) was sequenced. the determined nucleotide and the predicted amino acid sequences were compared to the corresponding sequences of av3 and av16. the hexons of av7 and av3 revealed an overall homology of 94.3% at the protein level, whereas the av7 and av16 hexons only showed an overall homology of 85.7%. utilizing the three-dimensional model of the av2 hexon, the structure of the av7 hexon was predicted. the major differences between the th ... | 1995 | 8834754 |
| nucleotide and amino acid sequence analysis of the porcine adenovirus 23k protein. | the genomic location of the viral encoded protease (23k) of porcine adenovirus serotype 3 (pav3) was determined and the appropriate fragment cloned and sequenced. an open reading frame (orf) coding for a polypeptide of 203 amino acids and a calculated molecular weight of 23.3 kda was found. the orf was situated in a position similar to that of the human adenovirus 23k, that is, between a putative stop codon for the hexon gene and the polyadenylation signal, aataaa, for the late region 3. amino a ... | 1996 | 8912929 |
| close phylogenetic relationship between egg drop syndrome virus, bovine adenovirus serotype 7, and ovine adenovirus strain 287. | a cloned egg drop syndrome (eds) virus genomic dna fragment containing the protease gene has been identified and the complete nucleotide sequence of the protease and partial nucleotide sequence of the hexon genes has been determined. phylogenetic analysis of the protease gene has revealed eds virus to be genetically more closely related to bovine adenovirus type 7 (bav-7) and ovine adenovirus isolate 287 (oav287) than either of these two viruses are to other members of the genus mastadenovirus o ... | 1997 | 9123875 |
| hydropathic characteristics of adenovirus hexons. | the complete nucleotide sequence and the predicted amino acid sequence of the adenovirus type 7 hexon gene were determined. the hydropathy of the hexon proteins from human adenovirus types 2, 3, 4, 5, 7, 12, 16, 40, 41, and 48, bovine adenovirus type 3, murine adenovirus type 1, and avian adenovirus types 1 and 10 was analysed. the presence of purines and pyrimidines in the second position of the codons was correlated to hydrophilicity and hydrophobicity, respectively. comparison of the hydrophi ... | 1997 | 9267445 |
| [analysis of genome types of adenovirus type 7 isolated in fukuoka prefecture in 1996]. | adenovirus type 7 (ad7) was rarely isolated in japan till 1994, but during april 1995 to august 1996, isolations of ad7 were reported 230 cases. we isolated ad7 in january and july 1996 in fukuoka prefecture. we analyzed its genome type by using 14 restriction endonuclease and studied seroepidemiology of ad7 infection in fukuoka prefecture. isolated ad7 strains were identical by 14 restriction endonuclease. between new ad7 isolates and prototype (gomen; ad7p), 4 restriction endonuclease patterns ... | 1997 | 9339625 |
| construction of an adenovirus type 7a e1a- vector. | a strategy for constructing replication-defective adenovirus vectors from non-subgroup c viruses has been successfully demonstrated with adenovirus type 7 strain a (ad7a) as the prototype. an e1a-deleted ad7a reporter virus expressing the chloramphenicol acetyltransferase (cat) gene from the cytomegalovirus promoter enhancer was constructed with dna fragments isolated from ad7a, an ad7a recombination reporter plasmid, and the 293 cell line. the ad7a-cat virus particle transduces a549 cells as ef ... | 1997 | 9343264 |
| [serosurvey for adenovirus type 3 and adenovirus type 7 infection in resident in gifu prefecture, 1996]. | | 1997 | 9483890 |
| molecular epidemiology of adenovirus type 7 in israel: identification of two new genome types, ad7k and ad7d2. | the molecular epidemiology of adenovirus type 7 in israel was investigated. fifty-seven adenovirus isolates identified as serotypes 7 or 7a which were recovered from patients in israel between 1968 and 1995 were analyzed by restriction enzymes digestion using bamhi for primary discrimination and identification of genome types and by six additional enzymes: bsteii, hpai, bgli, bglii, bcli, and xbai for confirmation and determination of genomic subtypes. four digestion patterns were identified wit ... | 1998 | 9557295 |
| genomic characterization of adenovirus serotype 7 isolated in brazil from acute respiratory disease patients during the period from 1980 to 1991. | forty isolates of adenovirus type 7 were analized by restriction enzyme digestion with bamhi, smai, ecori and hindiii. these isolates were obtained from acute respiratory disease patients during the years 1980 to 1991. only two genomic types were found: ad7b and ad7e, with ad7b (87.5%) being more frequent than ad7e (12.5%). the genomic type ad7e appeared in the years 1980, 1981 and 1983. ad7b appeared in 1982 and it was the only genomic type found from 1984 to 1991. both genomic types were respo ... | 1997 | 9640779 |
| [severe type 7 adenovirus pneumoniae in an immunocompetent adult]. | we report a case of severe adenovirus type 7 pleuropneumonia in an immunocompetent adult. the treatment required a mechanical ventilation with tracheostomy. the sequelae was a restrictive respiratory insufficiency. adenovirus is a common cause of pneumonia in children, in military recruits or in immunocompromised adults. however, it is an infrequent cause of such a severe complication in a healthy adult. | 1997 | 9686095 |
| outbreak of severe infection due to adenovirus type 7 in a paediatric ward in japan. | between november 1996 and january 1997, 14 patients were diagnosed as having infection caused by adenovirus type 7 in a paediatric ward of asahikawa kosei hospital. the age range of the patients was from two months to five years. their diseases and abnormal laboratory findings were pneumonia in all 14, leukocytopenia in 10, myositis in nine, gastroenteritis in eight, encephalitis in five, liver dysfunction in three, pleuritis in two, inappropriate secretion of antidiuretic hormone syndrome in tw ... | 1998 | 9699140 |
| [analysis of adenovirus type 7 hexon hypervariable region]. | the isolation of adenovirus type 7 (ad7) has been rare in japan in the past. however since april, 1995, many isolates of ad 7 have been reported. in order to find the cause of ad 7 re-emergence in japan, we investigated the genome sequences of ad 7 by analyzing the hexon hypervariable regions (hvrs). hvrs of genomes isolated before and after this prevalence showed little change and were closely related with each other. it was concluded that adenovirus hexon which contains hvrs is conserved in th ... | 1998 | 9785853 |
| trend of adenovirus type 7 infection, an emerging disease in japan. a report of the national epidemiological surveillance of infectious agents in japan. | the program of the national epidemiological surveillance of infectious diseases under the auspices of the ministry of health and welfare started in 1981 apprehended in 1995 emergence of adenovirus type 7 in japan. we analyzed the reported data of type 7 comparing with those of type 3, both belonging to the same subgenus b, and the following results were obtained: after 1981, the main serotypes in the reports of adenovirus isolation/detection were types 3, 2, and 1 in this order. the reports of i ... | 1998 | 10211431 |
| molecular and serological characterization of adenovirus genome type 7h isolated in japan. | in 1996, three adenovirus type 7 (ad7) strains were isolated from children with fever and upper respiratory diseases in japan. restriction endonucleases (res) analysis and pcr amplification of the e3 7.7 kda orf revealed that these strains were genotype ad7h and closely related to an argentine ad7h strain, which has been reported to be highly virulent and so far predominant only in south america. these strains showed weak cross-neutralizing activity and specific haemagglutination-inhibition acti ... | 1999 | 10355793 |
| [genome analysis of adenovirus type 7 and adenovirus type 11]. | to study the epidemiology of adenovirus type 7 (ad 7) conjunctivitis and adenovirus type 11 (ad 11) conjunctivitis by determining genome types and subgenome types. | 1999 | 10589237 |
| [relationship between epidemiological data of adenovirus type 7 in kawasaki city and restriction enzyme assay pattern of the virus]. | since april 1995 increased number of type 7 were isolated in japan and also in kawasaki city. from may 1996 to march 1999, adenovirus type 7 (ad7) were isolated from 49 patients with high body temperature, and longer febrile period were observed in infants and younger children. lower respiratory tract infection occurred and a young child developed fatal pneumonia. ad7 were isolated not only in summer but in winter. they were prevalent all season. we analyzed 27 strains of ad7 genetically using r ... | 1999 | 10655683 |
| [three cases with acute encephalopathy related with adenovirus type 7 infection]. | we studied the clinical and ct findings of 3 children with acute encephalopathy associated with adenovirus type 7 (ad-7) infection. seizures in all the patients developed from 8 to 10 days after the onset of pyrexia. the values of serum ast, ldh and crp elevated and those of wbc and serum protein decreased at the onset of encephalopathy. none of the patients had csf leukocytosis. ct showed mild brain atrophy in all patients. a steroid pulse therapy was effective in one patient. the pathogenesis ... | 2000 | 10655755 |
| adenovirus type 7 outbreaks in japan in 1998. | | 2000 | 10777856 |
| genome analysis of adenovirus type 7 and adenovirus type 11 | purpose: to study the epidemiology of adenovirus type 7 (ad 7) conjunctivitis and adenovirus type 11 (ad 11) conjunctivitis by determining genome types and subgenomic types.materials and methods: for ad 7 i used twelve strains from patients with acute viral conjunctivitis and one strain from a patient with pneumonia. for ad 11 i used seventeen strains from patients with cystitis. for ad 7 genome typing, i used eleven dna restriction endonucleases (res) recognizing 6- or 7-base pair sequences and ... | 2000 | 10913656 |
| advances in the management of hemophagocytic lymphohistiocytosis. | hemophagocytic lymphohistiocytosis (hlh) is a prototype of the hemophagocytic syndrome and occurs most often in children. progress in cytokine research has now made it possible to show that hlh occurs as a consequence of uncontrolled, dysregulated cellular immune reactivity caused by a number of different underlying diseases. three major risk groups of hlh can be identified: (1) familial hlh (fhl), (2) epstein-barr virus-associated hlh (ebv-hlh), and (3) life-threatening infection-associated or ... | 2000 | 10979202 |
| irreversible long-term pulmonary functional impairments after adenovirus type-7 pneumonia: assessment with xenon-133 ventilation and tc-99m maa perfusion studies. | a 3-year-old child presented with severe type-7 adenoviral pneumonia, after the resolution of diffuse pulmonary infiltrates of the pneumonia. xenon-133 ventilation and tc-99-m macroaggregated albumin (maa) perfusion studies revealed a localized airflow obstruction and matched perfusion defect, and marked air trapping in the remaining lungs, and these abnormalities were not detected and not suspected even with ct. thereafter, in a relatively short period, the child developed persistent bronchiect ... | 2000 | 10997429 |
| adenovirus type 7 penton purification of soluble pentamers from escherichia coli and development of an integrin-dependent gene delivery system. | adenoviral gene therapy vectors suffer from the disadvantages of toxicity and immunogenicity associated with the expression of adenoviral genes from the vector backbone. we report here an alternative strategy for gene delivery that utilizes a single component of the adenoviral type 7 capsid, the penton base (ad7pb). the ad7pb gene was sequenced and its amino-acid composition was deduced from its nucleotide sequence. the penton was expressed in escherichia coli as a soluble c-terminal fusion with ... | 2000 | 10998069 |
| a recent outbreak of adenovirus type 7 infection in a chronic inpatient facility for the severely handicapped. | | 2000 | 11001256 |
| genome analysis of adenovirus type 7 and adenovirus type 11. | to study the epidemiology of adenovirus type 7 (ad 7) conjunctivitis and adenovirus type 11 (ad 11) conjunctivitis in the japanese population by determining the genome type and sub-genome type. | 2001 | 11163042 |
| outbreak of adenovirus genome type 7d2 infection in a pediatric chronic-care facility and tertiary-care hospital. | an outbreak of adenovirus infection that involved residents of a pediatric chronic-care facility, staff of a tertiary-care hospital, and a nosocomial hospital case was studied. in the pediatric facility, 31 (33%) of 93 residents had adenovirus infection, and 8 died. risk factors for illness were an age of < 7 years (p = .004), presence of a tracheostomy (p = .015), and residence on a particular floor (p < .001). in the tertiary-care hospital, 36 health care workers had adenovirus infection; 26 ( ... | 2001 | 11229836 |
| a modified rapid method of nucleic acid isolation from suspension of matured virus: applied in restriction analysis of dna from an adenovirus prototype strain and a patient isolate. | this report describes a method for the isolation of nucleic acid from a suspension of matured virus. nucleic acid (dna) was isolated from a prototype strain of adenovirus type 7 and a clinical isolate of adenovirus type 7. instead of the usual method of ultracentifugation, a filtration method was applied to concentrate the virus rapidly and nucleic acid was then isolated by a standard phenol/chloroform/isoamyl-alcohol extraction procedure. the dna was found to be sufficiently purified to generat ... | 2001 | 11393295 |
| adenovirus type 7 induces interleukin-8 production via activation of extracellular regulated kinase 1/2. | infection with adenovirus serotype 7 (ad7) frequently causes lower respiratory pneumonia and is associated with severe lung inflammation and neutrophil infiltration. earlier studies indicated release of proinflammatory cytokines, specifically interleukin-8 (il-8), by pulmonary epithelial cells following infection by ad7. however, the mechanism of il-8 induction by ad7 is unclear. we have explored the role of the ras/raf/mek/erk pathway in the ad7-associated induction of il-8 using a model system ... | 2001 | 11413312 |
| fatal adenovirus type 7b infection in a child with smith-lemli-opitz syndrome. | adenovirus type 7 causes worldwide respiratory tract infections, mainly in children. severe systemic infections can occur, especially in immunocompromised patients and in patients with underlying chronic diseases. this report describes the first case of a fatal disseminated adenovirus type 7 infection in a child with smith-lemli-opitz syndrome, a rare autosomal recessive disorder due to a primary enzymatic defect in cholesterol metabolism. nasopharyngeal secretions and autopsy specimens includin ... | 2001 | 11505445 |
| [establishment and characterization of a cell line derived from human ovarian mucinous cystadenocarcinoma]. | to establish a cell line of human ovarian cancer, and study its characterization. | 2001 | 11718030 |
| molecular and epidemiological analyses of human adenovirus type 7 strains isolated from the 1995 nationwide outbreak in japan. | the adenovirus type 7 (ad7) isolates from the 1995 nationwide outbreak in japan were genetically and seroepidemiologically analyzed in comparison with japanese ad7 strains isolated before 1995 to determine their genome type and to speculate on their origin and causative factors of the outbreak. twenty-six ad7 isolates from the outbreak were identified by restriction enzyme analysis as the ad7d2 genome type, while 22 ad7 strains sporadically isolated in japan before 1995 were identified as ad7d. ... | 2002 | 11773107 |
| molecular epidemiology of adenovirus type 7 in the united states, 1966-2000. | genetic variation among 166 isolates of human adenovirus 7 (ad7) obtained from 1966 to 2000 from the united states and eastern ontario, canada, was determined by genome restriction analysis. most (65%) isolates were identified as ad7b. two genome types previously undocumented in north america were also identified: ad7d2 (28%), which first appeared in 1993 and was later identified throughout the midwest and northeast of the united states and in canada; and ad7h (2%), which was identified only in ... | 2002 | 11927024 |
| evidence for the presence of half-cystine residues in the capsid of adenovirus type 7. | | 1970 | 11947446 |
| adenovirus type 7 associated with severe and fatal acute lower respiratory infections in argentine children. | adenoviruses are the second most prevalent cause of acute lower respiratory infection of viral origin in children under four years of age in buenos aires, argentina. the purpose of this study was to analyze the clinical features and outcome of acute lower respiratory infection associated with different adenovirus genotypes in children. | 2002 | 12184818 |
| genetic organization and sequence analysis of pviii, fiber and early region 4 of bovine adenovirus type 7. | the dna sequence of 8,810 nucleotides at the right end of bovine adenovirus type 7 (bav7) genome was determined and compared with similar regions of other adenoviruses. this genomic region of bav7 consists of sequences encoding partial 33k, pviii, fiber, putative early region 4 (e4) proteins and other unassigned proteins. however, bav7 e3 region is not present in the expected location between pviii and fiber as bav7 intergenic region between pviii and fiber genes is only 183 nucleotides. the pre ... | 2002 | 12206309 |
| biology of ovine adenovirus infection of nonpermissive cells. | nonhuman adenoviruses, including those of the genus atadenovirus, have the potential to serve as vectors for vaccine and gene therapy applications in humans, since they are resistant to preexisting immunity induced by human adenoviruses in the majority of the population. in this study, we elucidate the outcome of infection by ovine adenovirus type 7 isolate 287 (oadv) of several nonovine cell types. we show here that oadv infects a wide range of nonovine cells but is unable to complete its repli ... | 2002 | 12368331 |
| [sequence analysis of ad7 vaccine strain 87 mu-97.4 mu fragment]. | adenovirus 7 vaccine strain(ad7v) possesses potentiality to be used as a vector for producing recombinant vaccine. in order to construct ad7 vector, the nucleotide sequence of a 3698 bp fragment(87 to 97.4 mu) of the virus dna was analysed. the fragment encodes three orfs namely, one orf of early region 4(e4), one orf of early region 3 and one orf of fiber protein. the predicted amino acids of three orfs(orf 8.1 kd, 42.8 kd and 10.3 kd) share 33%, 43% and 44% homology with ad2 e4 corresponding r ... | 1998 | 12515181 |
| [cloning and sequencing of adenovirus type 7 vaccine strain 76.5-87 mu fragment]. | adenovirus 7(ad7) vaccine strain has been used more than 30 years in us army recruits for prevention of ad7 infection and has been proven to be safe and effective. recent years more attention has been paid to exploring the possibilities of using it for gene therapy or making recombinant vaccine. in order to construct adenovirus 7 vector, ad 7 vaccine strain 76.5-87 mu fragment was cloned and sequenced. the fragment contains 3,557 bp which encodes 6 proteins of e3 region, namely 12.1 kd, 19.2 kd, ... | 1998 | 12526316 |
| [construction of adenovirus type 7(vaccine strain) vector and expression of beta-galactosidase gene]. | human adenovirus type 7 dna was extracted from purified virus cultured in wi-38 cells. the essential fragment (68-100 mu) of ad7 dna was used for constructing a non-defective ad7 vector termed as pad7 delta e3. the vector was characterized by a deletion at the e3 region that contains a multicloning site for the insertion of foreign genes. a helper-independent adenovirus type 7-beta-galactosidase recombinant was established. the recombinant contains the beta-galactosidase gene flanked by cmv earl ... | 1998 | 12526338 |
| adenovirus meningoencephalitis in a patient with large b-cell lymphoma. | we report a case of a 58-year-old female with neuromeningeal relapse of a large b-cell lymphoma which developed a meningoencephalitis due to adenovirus (adv). diagnosis of suspected viral meningoencephalitis was based on computed tomography (ct) scan radiological pictures, which were atypical for cns neoplastic infiltrations, and it was confirmed by direct immunofluorescence performed on cerebrospinal fluid. cultural exams identified adenovirus type 7. the adv infection resolved after treatment ... | 2003 | 12679888 |
| genome types of adenovirus type 7 isolated in hiroshima city. | one hundred thirty-two strains of adenovirus type 7 were isolated in hiroshima city during the period 1995-1999. about 80% of the viruses were isolated from patients with respiratory illness, and about 70% were isolated from children younger than 6 years old. dna restriction analysis was performed on 58 of the 132 isolates. two genome types corresponding to adenovirus 7d and adenovirus 7h were recognized using bamhi. by using an additional 10 restriction endonucleases (bcli, bgli, bglii, bsteii, ... | 2003 | 12683410 |
| adenoviruses associated with pharyngoconjunctival fever; isolation of adenovirus type 7 & serological studies suggesting its etiological role in an epidemic in helsinki. | | 1957 | 13470509 |
| [study of the cytopathogenic action of adenovirus type 7 in cell cultures]. | | 1958 | 13534084 |
| infections with adenovirus type 7 in children and their relationship to acute respiratory disease. | | 1959 | 13649352 |
| association between diarrhoea and adenovirus type 7. | | 1960 | 13826535 |
| an electron microscope study of the early association between two mammalian viruses and their hosts. | early interaction between two animal viruses, vaccinia and adenovirus 7, which multiply readily in l strain and hela cells, respectively, was examined in both whole mount preparations and in thin sections. to observe the association at the surface, cells carrying adsorbed virus were swelled under controlled conditions and then "stained" with neutral phosphotungstate. each particle of both virus types becomes attached to the cell by several capsomeres and is then ingested by phagocytosis. within ... | 1962 | 13883196 |
| the isolation of adenovirus type 7 from a fatal case of pneumonia and disseminated disease. | | 1964 | 14100105 |
| [familial epidemic of adenovirus type 7 disease with encephalitic and blood manifestations]. | | 1964 | 14135064 |
| tests in hamsters for oncogenic quality of ordinary viruses including adenovirus type 7. | | 1964 | 14166581 |
| induction by adenovirus type 7 of tumors in hamsters having the antigenic characteristics of sv40 virus. | | 1964 | 14243505 |
| evidence for a possible genetic hybrid between adenovirus type 7 and sv40 viruses. | | 1964 | 14243506 |
| the incorporation of sv40 material into adenovirus 7 as measured by intranuclear synthesis of sv40 tumor antigen. | | 1964 | 14243507 |
| studies of oncogenicity of adenovirus type 7 virus in hamsters. | | 1965 | 14254534 |
| a hospital epidemic of keratoconjunctivitis caused by adenovirus type 7 in helsinki. | | 1965 | 14293652 |
| adenovirus type 7 outbreak in a kindergarten. | | 1965 | 14345173 |
| epidemic occurrence of adenovirus type 7 infection in helsinki. | | 1962 | 14451250 |
| [an epidemic among children caused by adenovirus type 7. i. symptoms in patients in whom the virus was isolated]. | | 1962 | 14453805 |
| [an epidemic among children caused by adenovirus type 7. ii. etiologic study]. | | 1962 | 14453806 |
| novel 1,2,5-oxadiazine derivatives--synthesis and in vitro biological studies. | a new synthetic approach to the 1,2,5-oxadiazine ring system is described. 2-substituted or 2,4-disubstituted 2h-1,2,5-oxadiazine-3,6(4h,5h)-dione derivatives 4 were prepared by cyclisation of hydroxamic acids 3 derived from n-(1-benzotriazolylcarbonyl)-amino acids 1. the structures of the synthesised compounds were fully characterised by ir, 1h and 13c nmr spectroscopy and elemental analysis. the aim of this study was to evaluate biological activity of the newly synthesised oxadiazine derivativ ... | 2003 | 14769241 |
| adenovirus type 7 induces interleukin-8 in a lung slice model and requires activation of erk. | adenovirus (ad), particularly ad type 7 (ad7), causes severe lung infection and pneumonia. initially, ad causes neutrophilic inflammation of the distal airways and alveoli. interleukin-8 (il-8) is the major lung neutrophil chemotaxin, and we have shown that ad7 induces il-8 release from the a549 alveolar epithelial cell line. we sought to determine whether ex vivo human and bovine lung tissue containing primary pneumocytes could be used as a more accurate and relevant model to study ad acute inf ... | 2004 | 15047831 |
| adenovirus type 7 genomic-type variant, new york city, 1999. | an outbreak of respiratory illness occurred in a long-term care facility in new york city. investigation of the outbreak identified confirmed or suspected adenoviral infection in 84% of the residents from october 19 to december 18, 1999. further identification by type-specific neutralization and restriction analysis identified a new genomic variant of adenovirus type 7. | 2004 | 15078614 |
| [sequencing of adenovirus type 7 vaccine strain fragment and characterization of the hexon encoding gene]. | to complete the full-length sequencing of the human adenovirus type 7 vaccine strain (ad7v) for novel vector constructing. | 2003 | 15340538 |
| genomic and bioinformatics analysis of hadv-7, a human adenovirus of species b1 that causes acute respiratory disease: implications for vector development in human gene therapy. | human adenovirus serotype 7 (hadv-7) is a reemerging pathogen identified in acute respiratory disease (ard), particularly in epidemics affecting basic military trainee populations of otherwise healthy young adults. the genome has been sequenced and annotated (genbank accession no. ). comparative genomics and bioinformatics analyses of the hadv-7 genome sequence provide insight into its natural history and phylogenetic relationships. a putative origin of hadv-7 from a chimpanzee host is observed. ... | 2005 | 15661145 |
| viral and bacterial pathogens in bovine respiratory disease in finland. | pathogens causing bovine respiratory tract disease in finland were investigated. eighteen cattle herds with bovine respiratory disease were included. five diseased calves from each farm were chosen for closer examination and tracheobronchial lavage. blood samples were taken from the calves at the time of the investigation and from 86 calves 3-4 weeks later. in addition, 6-10 blood samples from animals of different ages were collected from each herd, resulting in 169 samples. serum samples were t ... | 2004 | 15663079 |
| emergent strain of human adenovirus endemic in iowa. | we evaluated 76 adenovirus type 7 (ad7) isolates collected in iowa from 1992 to 2002 and found that genome type ad7d2 became increasingly prevalent. by 2002, it had supplanted all other ad7 genome types. the association of ad7d2 with severe illness and death calls for heightened public health concern. | 2005 | 15705336 |
| viral diarrhea in japanese children: results from a one-year epidemiologic study. | a total of 557 fecal specimens from infants and children with acute gastroenteritis in five places (maizuru, tokyo, sapporo, saga and osaka) in japan from july 2002 to june 2003 were tested for the presence of diarrheal viruses by rt-pcr, prha, rna-page and latex agglutination methods. of these, 56.4% (314) were found positive for diarrheal viruses. among them, group a rotavirus was the most prevalent (43.6%, 137 of 314) followed by norovirus (29.9%, 94 of 314), adenovirus (7.6%, 24 of 314), gro ... | 2005 | 15819174 |
| adenovirus type 7 peptide diversity during outbreak, korea, 1995-2000. | to understand the molecular basis of observed regional shifts in the genome types of adenovirus type 7 (ad7) isolated in korea during nationwide outbreaks from 1995 to 2000, the genetic variabilities of ad7d and ad7l were studied by sequence analysis of hexon, fiber, e3, and e4 open reading frame (orf) 6/7 peptides. one amino acid change in the receptor-binding domain of fiber and 6 amino acid variations in e4 orf 6/7 were identified between 2 genome types, while no variations were found in hexo ... | 2005 | 15890114 |
| [quantitative fluorogenic real-time pcr assay for respiratory syncytial virus detection]. | to establish a rapid and objective quantitative fluorogenic real-time pcr assay for early detection of human respiratory syncytial virus (hrsv). | 2005 | 16027084 |
| ten-year analysis of adenovirus type 7 molecular epidemiology in korea, 1995-2004: implication of fiber diversity. | adenovirus type 7 (ad7) is frequently responsible for severe respiratory infections, especially in young infants. since the ad7 epidemics have been associated with severe childhood pneumonia and significant mortality in korea, 1995-1999, continuous surveillance was necessary for ad7 related diseases. | 2006 | 16458589 |
| influence of sv40 genome on the replication of an adenovirus-sv40 "hybrid" population. | feldman, l. a. (baylor university college of medicine, houston, tex.), j. l. melnick, and f. rapp. influence of sv40 genome on the replication of an adenovirus-sv40 "hybrid" population. j. bacteriol. 90:778-782. 1965.-replication of a type 7 adenovirus-sv40 hybrid population in primary african green monkey kidney cells was accompanied by the formation of sv40 tumor antigen, adenovirus antigens, and cytopathic changes characteristic of adenovirus infection. prior infection of the cultures with sv ... | 1965 | 16562080 |
| detection of biologically active adenovirions unable to plaque in human cells. | butel, janet s. (baylor university college of medicine, houston, tex.), joseph l. melnick, and fred rapp. detection of biologically active adenovirions unable to plaque in human cells. j. bacteriol. 92:433-438. 1966.-plaque formation in green monkey kidney (gmk) cells by a defective simian virus 40-adenovirus 7 "hybrid" population (para-adenovirus 7) was enhanced by the addition of excess adenovirions. adenovirus types 2, 7, and 12 were capable of providing enhancement, although none of these vi ... | 1966 | 16562132 |
| density differences between hybrid and nonhybrid particles in two adenovirus-simian virus 40 hybrid populations. | the adenovirus 7-simian virus 40 hybrid virus population e46(+) was subjected to fixed-angle equilibrium density gradient centrifugation in cscl. a difference in buoyant density between the hybrid virion and its nonhybrid adenovirus 7 counterpart was noted, the hybrid virion possessing the lower buoyant density. this difference in buoyant density appeared to be accentuated in a population of adenovirus 2(+t7), a derivative of e46(+) in which the adenovirus 7-simian virus 40 genome had been trans ... | 1970 | 16789126 |
| simian virus 40 dna segment of the adenovirus 7-simian virus 40 hybrid, e46, and its transcription during permissive infection of monkey kidney cells. | nucleic acid hybridization methodology has been used to investigate the span of the simian virus 40 (sv40) dna segment in the adenovirus 7-sv40 hybrid, e46(+), and the extent of its transcription in lytically infected monkey kidney cells. the sv40 segment of e46(+) comprises approximately 62% of the sv40 genome; it originates in the proximal region of hin-g (the g fragment derived by cleavage of intact sv40 dna with haemophilus influenzae restriction endonuclease), extends sequentially through a ... | 1975 | 16789154 |
| structure of the dna of the adenovirus 7-simian virus 40 hybrid, e46, by electron microscopy. | the dna molecule of the adenovirus 7-simian virus (sv) 40 hybrid, e46(+), contains a single substitution of sv40 dna located about 0.05 adenovirus 7 lengths from one end (arbitrarily designated the left end). the left to right direction in the sv40 dna segment of the hybrid corresponds to the clockwise direction in the sv40 physical map. the left end point of the segment maps at about sv40 map position 0.50 +/- 0.01 and the right end point at about sv40 map position 0.66 +/- 0.01. the region bet ... | 1975 | 16789158 |
| a slow spread of adenovirus type 7 infection after its re-emergence in yamagata, japan, in 1995. | we have continued the epidemiological study on adenovirus type 7 (ad7), which re-emerged in 1995 in yamagata, japan. between 1999 and 2004, we isolated only four strains from 10,778 throat swab specimens among children with acute respiratory infections. a serological survey of 303 specimens revealed the antibody-positive rate against ad7 to be 0-7.4% in children under 10 years of age in 2005, although it was 3.3-16.7% in 1997 and 0% in 1993. our results suggest that a re-emergence does not alway ... | 2006 | 16858147 |
| calcium-dependent viral internalization is required for adenovirus type 7 induction of il-8 protein. | the host response to adenovirus (ad) infection involves induction of cytokines in lung epithelia. we have demonstrated induction of the lung neutrophil chemokine interleukin-8 (il-8) by ad7, a major lung pathogen, in a549 lung epithelial cells and lung tissue through activation of the erk signaling pathway. however, the mechanism of il-8 induction is still unclear. in this paper, we first showed that ad7 viral gene expression is not essential for il-8 induction as psoralen-uv inactivation of ad7 ... | 2006 | 16890267 |
| association of bovine respiratory disease with clinical status and acute phase proteins in calves. | eighty-four calves with respiratory disease from 18 herds in different parts of finland were chosen for a study evaluating the capacity of different respiratory pathogens to cause changes in different acute phase protein concentrations, white blood cell (wbc) count and clinical signs. the selected acute phase proteins were fibrinogen, haptoglobin, serum amyloid-a, lipopolysaccharide binding protein and alpha1-acid glycoprotein. from each calf, a paired blood sample was obtained for serological s ... | 2007 | 17258318 |
| antiviral activity of arbidol against influenza a virus, respiratory syncytial virus, rhinovirus, coxsackie virus and adenovirus in vitro and in vivo. | arbidol, ethyl-6-bromo-4-[(dimethylamino)-methyl]-5-hydroxy-1-methyl-2-[(phenylthio)methyl]-in dole-3-carboxylate hydrochloride monohydrate, is an antiviral chemical agent. in this report, we studied the antiviral activity of arbidol against a panel of human respiratory viruses, namely influenza a virus (flu-a, a/pr/8/34 h1n1), respiratory syncytial virus (rsv), human rhinovirus type 14 (hrv 14), coxsackie virus b3 (cvb3) and adenovirus type 7 (adv-7) in vitro in cell culture. arbidol was found ... | 2007 | 17497238 |
| adenovirus multiplication: genetic relatedness of tumorigenic human adenovirus types 7, 12, and 18. | hybridization measurements among the dna's of six weakly tumorigenic strains of human adenovirus type 7 reveal that all six strains are very closely related (83- to 110-percent nucleotide sequence homology). the dna homology between these six type 7 strains and nontumorigenic types 2 and 4 is 32 percent and 52 percent, respectively. the 10- to 20-percent homology between the type 7 dna's and those of "potent" tumorigenic types 12 and 18 indicates a very low degree of genetic relatedness. these d ... | 1965 | 17751853 |
| etiology of acute diarrhea in children and adults in tunis, tunisia, with emphasis on diarrheagenic escherichia coli: prevalence, phenotyping, and molecular epidemiology. | a total of 271 stool specimens were collected from children (diarrheagenic, n = 115 and control, n = 54) and adults (diarrheagenic, n = 73 and control, n = 29) from tunis, tunisia, and processed to detect bacterial enteropathogens, parasites, and viruses. diarrheagenic escherichia coli (dec) were identified by their virulence genes (polymerase chain reaction) and adherence patterns (tissue culture assays). the most frequently isolated enteric pathogens from diarrheagenic children were enterotoxi ... | 2007 | 17827382 |
| [identification and typing for adenovirus by multiplex nest-pcr]. | to develop a rapid, sensitive and specific method in identifying and typing on adenovirus from clinical specimens. | 2007 | 18080566 |
| evaluation of the pathogenic potential of cervid adenovirus in calves. | four 3-month-old jersey calves and three 3-month-old holstein calves were inoculated with cervid adenovirus and monitored for clinical signs until necropsied between 10 and 42 days postinoculation. the neonatal jersey calves had received colostrum, and the holstein calves were colostrum deprived. preinoculation and postinoculation serum samples were tested for antibodies to the cervid adenovirus, bovine adenovirus type 6, bovine adenovirus type 7, and goat adenovirus type 1. virus isolation was ... | 2008 | 18182505 |
| serologic and hexon phylogenetic analysis of ruminant adenoviruses. | the objectives of this study were to determine the antigenic relationship among ruminant adenoviruses and determine their phylogenetic relationship based on the deduced hexon gene amino acid sequence. results of reciprocal cross-neutralization tests demonstrated antigenic relationships in either one or both directions among bovine adenovirus type 6 (badv-6), badv-7, ovine adenovirus type 7 (oadv-7), caprine adenovirus type 1 (gadv-1), and deer adenovirus (odocoileus adenovirus 1, odadv-1). no an ... | 2008 | 18340400 |