| a complementary method for the quantitative evaluation of rat stomach with shay-ulcer. | | 1975 | 1499 |
| comparative study on the effect of neostigmine, trimetaphan an oxyphenonium on some aspects of 5-hydroxytryptamine metabolism in rats. | | 1975 | 1501 |
| dissociation by the aporphine derivatives of the stereotypic and hyperactivity responses resulting from injections into the nucleus accumbens septi. | | 1975 | 1503 |
| evaluation of the permanent sympathectomy produced by the administration of guanethidine to adult rats. | the administration of guanethidine to adult rats has been shown by morphological criteria to destroy sympathetic neurons. the objective of this study was to evaluate by biochemical and functional criteria the degree and permanence of this sympathectomy. young adult male rats (260-300 g) were injected with saline (controls) or with guanethidine for 5 weeks. the status of the sympathetic nervous system in the animals was evaluated 1, 3 and 6 to 7 months after cessation of treatment. seven months a ... | 1976 | 1517 |
| barbiturates block calcium uptake by stimulated and potassium-depolarized rat sympathetic ganglia. | the effects of two barbiturates on calcium uptake by sympathetic ganglia have been examined. sodium pentobarbital (0.4-0.75 mm) and sodium thiopental (0.3 mm) block the preganglionic stimulation-induced uptake of 45ca by rat superior cervical ganglia but not action potential conduction in the presynaptic axons. the ganglionic-blocking agent, tetraethylammonium, does not inhibit stimulation-induced ca uptake and does not prevent the blocking effect of thiopental. this effect is therefore probably ... | 1976 | 1519 |
| an alkyl etherase in rat liver. | 1. diethyl ether, which is known to be partly metabolized in vivo, has been found to show an o2 uptake with the rat liver microsomal membranes; a similar reaction is given with other short chain aliphatic ethers, isoproply and n-butyl ether. 2. the "etherase" reaction is optimal at ph 7.2-7.4 and is not accompanied by an increased formation of malondialdehyde. 3. when coa is added to the microsomes together with a source of oxaloacetate and the consensing enzyme synthase, the etherase present fo ... | 1975 | 1521 |
| adrenergic and cholinergic control of oxytocin release evoked by vaginal, vagal and mammary stimulation in lactating rats (author's transl). | 1. the amounts of oxytocin released during ferguson and vago-pituitary reflexes are estimated by measurements of intramammary pressure. for the milk-ejection reflex, the gain in weight of the young over a period of 30 minutes is taken as an indirect index of the release of oxytocin. 2. antagonists of specific cholinoceptors and adrenoceptors were injected into the third ventricle in order to delineate the role of the mediators and receptors in the control of oxytocin release. 3. the results sugg ... | 1975 | 1524 |
| importance of the aromatic ring in adrenergic amines. 2. synthesis and adrenergic activity of some nonaromatic six- and eight-membered ring analogs of beta-phenylethanolamine. | the synthesis of beta-phenylethanolamine analogs in which the phenyl ring is replaced by cyclohexyl, cyclohexen-4-yl, cyclooctyl, cyclooctenyl, cycloocta-1,3-dien-2-yl, cycloocta-1,5-dienyl, and cyclooctatetraenyl was accompanied by conversion of the corresponding aldehydes to the cyanohydrins followed by reduction with lithium aluminum hydride. a preparatively useful synthesis of 1-formylcyclooctatetraene is described utilizing the photocycloaddition of methyl propiolate to benzene followed by ... | 1976 | 1534 |
| synthesis and adrenoreceptor blocking action of aziridinium ions derived from phenoxybenzamine and dibenamine. | crystalline perchlorate salts of aziridinium ions derived from phenoxybenzamine and dibenamine were prepared. both aziridinium ions were tested on the rat vas deferens and found to possess alpha-adrenergic potencies which were nearly identical with those of the parent compounds. the hydrolysis rates of phenoxybenzamine and dibenamine aziridinium ions (2a,b) in physiological medium were found to be 6.0 4 x 10(-4) and 8.35 x 10(-4) sec-1, respectively. the rates of cyclization of the parent amines ... | 1976 | 1536 |
| enzymic deacetylation of carcinogenic arylacetamides by tissue microsomes of the dog and other species. | the relative ability of arylacetamide deacetylase enzyme systems of dog liver to carry out the deacetylation of the carcinogens, 4-acetylaminobiphenyl, 2-acetylaminofluorene, and 2-acetylaminaphthalene, was examined. the arylacetamides were incubated with unfortified dog liver microsomes, and enzyme activity (nmol arylamine/mg protein/hr) was estimated by colorimetric quantitation of the resulting arylamines. the dog liver enzyme system displayed characteristics similar to those described for th ... | 1976 | 1550 |
| renal chromium accumulation and its relationship to chromium-induced nephrotoxicity. | this report is an attempt to study the renal handling of chromium under in vitro conditions and to relate this to the actions of the ion in the production of nephrotoxicity. renal slice techniques were employed in these studies and were used to examine the effects of chromium on various renal transport processes. in addition, the accumulation of chromium by the renal tissue has also been studied. marked accumulation by renal cortical slices of the rat was observed when 51cr-labeled chromate or d ... | 1976 | 1551 |
| effects of antidepressant drugs on amygdaloid after-discharge in rats. | effects of antidepressant drugs on the amygdaloid after-discharge induced by stimulating the amygdala in rats implanted with chronic electrodes, were investigated in correlation with anti-muricidal effects as well as neurotoxicity. tricyclic antidepressants such as amitriptyline, imipramine and nortriptyline markedly depressed both after-discharge and muricide at doses smaller than neurotoxic doses. the effect of pf-257 was also the same as tricyclic antidepressants. on the other hand, methamphe ... | 1975 | 1561 |
| effects of several beta-blockers on blood pressure in the rat. | effects of practolol, alprenolol and pindolol on blood pressure in the rat were studied. also effects of these three beta-blocking agents on blood pressure and heart rate in spinal rats during adrenaline infusion were studied and compared with those of propranolol. the beta-blocking agents produced a sustained pressor action in the rat, and in the spinal rat infused with adrenaline. the magnitude of the pressor action induced by the beta-blockers was in the following order: pindolol larger than ... | 1975 | 1562 |
| nonachlasine--a new drug for treatment of ischemic heart disease. | data on the pharmacology of a new antianginal drug--nonachlasine--are presented. nonachlasine was found to increase the blood flow intensively and for long periods of time, increasing the oxygen reserve of the myocardium, thus increasing the cardiac output and the contractile function of the heart. the prevailing action of nonachlasine on the blood supply and the function of the myocardium seems to be the result of several mechanisms: decreasing resistance of the coronaries due to the activation ... | 1975 | 1569 |
| toxic properties of regenerated water containing methyl alcohol. | the experiments carried out on white male rats have shown no significant changes in the animals that may have resulted from their 30-day consumption of reclaimed water which contained up to 34 mg/l methanol and was produced by sorption purification of the atmospheric condensate during a prolonged manned experiment. | 1975 | 1578 |
| demonstration of t-cell activation using synthetic polynucleotides. | the present data show that spn have a striking influence on thymus dependent t cells. the enhancing effect of gvh reactions on antibody formation against thymus dependent antigens give a good explanation for the antitumor effects of this substance. | 1975 | 1608 |
| the effect of hormones on glucocorticoid binding capacity of rat liver cytosol. | | 1975 | 1612 |
| topography of synaptosomal high affinity uptake systems. | | 1975 | 1614 |
| influence of ionophores which bind calcium on the release of norepinephrine from synaptosomes. | | 1975 | 1618 |
| diurnal variations in activity of four pyridoxal enzymes in rat liver during metabolic transition from high carbohydrate to high protein diet. | | 1975 | 1619 |
| regulatory function of pyruvate dehydrogenase and the mitochondrion in lipogenesis. | the activity of pyruvate dehydrogenase from freshly isolated mitochondria was shown to be dependent upon the nutritional and metabolic state of the animal prior to sacrifice, such that mitochondria from the livers of 48 hr starved, diabetic, or high fat fed rats had lower enzyme activity than normal, chow fed rats. the activity of pyruvate dehydrogenase and the rate of lipogenesis were shown to correlate to a certain extent when a reconstituted, cell free system consisting of 105,000 x g superna ... | 1975 | 1620 |
| studies in vitro of lipogenesis in rat testicular tissue. | testicular tissue was shown to contain the full complement of enzymes required for de novo synthesis of fatty acids. the enzymes capable of snythesizing palmitic acid from citrate, acetate, or acetyl coa were found to be present in the soluble (cytoplasmic) fraction. these included fatty acid synthetase, acetyl coa carboxylase, citrate-cleavage enzyme, malic enzyme, glucose-6-phosphate dehydrogenase, and 6-phosphogluconate dehydrogenase. optimal conditions for assaying activities of fatty acid s ... | 1975 | 1621 |
| fatty acid synthesis from 2-14c-acetate in rat testis mitochondrial and cytosol fractions in vitro. | an in vitro system for acetate incorporation into fatty acids by the mitochondrial and the cytosol fractions of rat testis is described. the rate of incorporation of acetate into fatty acids was twice as fast with the mitochondrial as with the cytosol fraction; both systems were stimulated in the presence of adenosine triphosphate, reduced nicotinamide adenine dinucleotide phosphate, coenzyme a, and mgc1(2). the optimum ph was between 7.0-7.5 for the mitochondrial fraction and between 6.5-8.0 fo ... | 1975 | 1622 |
| turnover rate of tyrosine hydroxylase during trans-synaptic induction. | | 1975 | 1666 |
| a re-evaluation of the optical titrations of the 430 and 455 nm chromophore of ethyl isocyanide complexes of mamalian hepatic cytochrome p-450. | | 1975 | 1667 |
| enzyme induction (third of three parts). | | 1976 | 1671 |
| regulation of lipid synthesis in animal organs. | studies were made of the mechanisms regulating the quantity and catalytic efficiency of hepatic acetyl coenzyme a carboxylase, which plays a critical role in the control of fatty acid biosynthesis. the microsomal enzyme system responsible for the formation of phosphatidic acid, the initial step in glycerolipid biosynthesis, was resolved into two component enzymes. the acyl-donor specificities of these and other acyltransferases account for the asymmetric fatty acid distribution in naturally occu ... | 1975 | 1682 |
| norepinephrine reward pathways: role of self-stimulation, memory consolidation, and schizophrenia. | | 1975 | 1688 |
| concanavalin a-binding glycopeptides from rat brain glycoproteins. | the affinity of concanavalin a for neutral and acidic glycopeptides derived from rat brain glycoproteins was investigated by studying the inhibition of a concanavalin a-glycogen precipitation system. the neutral, mannose-rich glycopeptides obtained by column electrophoresis of the dialyzable glycopeptides that had been solubilized by proteolytic treatment of defatted brain tissue were powerful inhibitors, with an inhibitory activity 20 to 26 times that of the standard inhibitor, methyl-alpha-d-m ... | 1975 | 1690 |
| changes in hypothalamic neurotransmitter uptake following pinealectomy, superior cervical ganglionectomy or melatonin administration to rats. | rats subjected to pinealectomy or to pinealectomy plus bilateral superior cervical ganglionectomy exhibited depressed serotonin uptake by hypothalamic synaptosomes; norepinephrine, dopamine or glutamate uptake was not affected by any of the surgical procedures. treatment with melatonin resulted in inhibition of hypothalamic serotonin accumulation but it did not modify the uptake of norepinephrine, dopamine or glutamate. these data suggest a relationship between the pineal gland and the serotonin ... | 1975 | 1692 |
| effects of pharmacological agents on 14c-nicotine distribution and movements in slices from different rat brain areas. | | 1975 | 1693 |
| gamma-glutamyltranspeptidase in the rat liver after portacaval shunt. | gamma-glutamyltranspeptidase (ggtp) activity was studied in livers of rats submitted to an end-to-side portacaval shunt (pcs) and in developing animals. to correlate the evolution of the enzymatic activity measured in vitro, histochemical techniques were used to localize enzyme activity in liver tissue. the ggtp activity in the adult rats was low and amounted to 2.0 +/- 0.1 mumol/min/g. during fetal development the enzyme activity rose beginning on the 15th gestational day from 630 +/- 97 to 1,0 ... | 1976 | 1703 |
| diminished pulmonary lecithin synthesis in acidosis: experimental findings as related to the respiratory distress syndrome. | lung slices from term fetal rats were incubated in vitro at various ph values and the rates of the two de novo pathways for lecithin biosynthesis were determined by measuring the conversion of either 14c-choline (pathway 1) or 14c-methionine (pathway 2) to the phospholipid. it was observed that the choline pathway, but not phosphatidylethanolamine methylation, is ph-sensitive with maximum rates occurring at ph levels between 7.3 and 7.5; significantly less activity was found at ph levels between ... | 1976 | 1706 |
| ph and bicarbonate excretion in the rat parotid gland as a function of salivary rate. | the bicarbonate concentration in rat parotid saliva increases with increasing flow rates and approximates plasma values at highest salivation. at lowest flow rates the bicarbonate concentration in the secretory fluid markedly exceeds the plasma levels. intravenous administration of acetazolamide has no influence on the bicarbonate excretion of the parotid gland. following retrograde application of acetazolamide into the gland duct the concentrations of both bicarbonate and sodium are elevated. t ... | 1975 | 1707 |
| h+ transport and membrane-bound hco - 3 atpase in salivary duct epithelium. | an atpase stimulated by hco - ions and other oxybases and inhibited by scn- has been found in main excretory duct of rat submaxillary gland, a tissue, capable of actively secreting hco - 3 ions. no such atpase was found in the rabbit duct, which normally does not secrete hco - 3. the hco - 3 atpase was localized in the plasma membrane fraction of the homogenate, as evidenced by the marker 5'-nucleotidase. the activities of the hco - 3 atpase increased in metabolic alkalosis and decreased in met ... | 1975 | 1708 |
| the effect of alpha-adrenolytics on the levels of 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in rat's brain. | alpha-adrenolytics (aba)-phenoxybenzamine, phentolamine and aceperone-increase 5-hydroxyindoleacetic (5-hiaa) acid content in rat's brain. at the same time, these compounds either increase or do not affect 5-hydroxytryptamine (5-ht) level. moreover, they potentiate l-dopa and reserpine-induced increase in 5-hiaa level and antagonized clonidine-induced decrease in 5-hiaa content. the experiments with probenecid indicate that the observed increase in 5-hiaa does not result from the deficient elimi ... | 1975 | 1713 |
| the central action of drugs influencing beta-adrenergic receptor. part v. the interaction of drugs affecting beta-adrenergic receptor in motility test. | propranolol, alprenolol and sotalol given intraventricularly (ivc) to rats reduce depressing effects of isoprenaline (ips) and antagonize stimulating effects of noradrenaline (na). phentolamine given by the same route of administration does not affect ips action. | 1975 | 1714 |
| the effect of alpha, alpha1-dipyridyl on noradrenaline, dopamine and 5-hydroxytryptamine levels and on dopamine-beta-hydroxylase activity in brain. | the effects of alpha, alpha1-dipyridyl (dp) on noradrenaline (na), dopamine (da) and 5-hydroxytryptamine (5-ht) levels in rat and mouse brain and on dopamine-beta-hydroxylase (dbetah) activity in rat brain have been studied, dp decreases na level and inhibits dbetah activity in a dose dependent manner, without affecting da or 5-ht levels. | 1975 | 1715 |
| beta-bungarotoxin, a pre-synaptic toxin with enzymatic activity. | beta-bungarotoxin, a pre-synaptic neurotoxin isolated from the venom of the snake bungarus multicinctus, has been shown to modify release of neurotransmitter at the neuromuscular junction. in this communication, we demonstrate that beta-bungarotoxin is a potent phospholipase a2 (phosphatide 2-acyl hydrolase, ec 3.1.1.4), comparable in activity with purified phospholipase enzymes from naja naja and vipera russellii. the phospholipase activity of beta-bungarotoxin requires calcium and is stimulate ... | 1976 | 1749 |
| cyclic nucleotide metabolism in compensatory renal hypertrophy and neonatal kidney growth. | cyclic nucleotide metabolism was investigated in growing kidneys of rats during compensatory hypertrophy and during neonatal development. after unilateral nephrectomy a mild and short-lasting decrease in cyclic 3':5" adenosine monophosphate (camp) was observed in the hypertrophying kidney. in contrast, cyclic 3':5' guanosine monophosphate (cgmp) showed a sharp decline to 20% of control at 15 min and a rapid rise to 200-300% above base-line at 1-72 hr. the alterations in renal tissue levels of cg ... | 1976 | 1760 |
| hormonal regulation of fatty acid synthesis in adipose tissue through changes in the activities of pyruvate dehydrogenase (ec 1.2.4.1) and acetyl-coa carboxylase (ec 6.4.1.2). | | 1975 | 1764 |
| direct measurement by ph-microelectrode of the ph microclimate in rat proximal jejunum. | | 1975 | 1788 |
| thyroxine deiodination associated with nadph-dependent lipid peroxidation in a submicrosomal system. | a lipoprotein present in trypsin-treated microsomes can be oxidized with formation of malondialdehyde in a system which contains nadph, ferric ion-adp complex, nadph-cytochrome c reductase and a factor. this factor, a mixture of peptides, can be isolated from hepatic microsomes by trypsin digestion and successive gel filtration through sephadex g-100 and g-25 columns. lipid peroxidation in this system catalyzes the deiodination of thyroxine, as does nadph-dependent lipid peroxidation in fresh he ... | 1975 | 1791 |
| effects in the rat of intradermal injection of purified proteinases from streptococcus and serratia marcescens. | purified streptococcal proteinase and serratia proteinase are potent permeability factors in rat skin and initiate histopathological evidence of an acute inflammatory response. these effects appear to be largely independent of terminal components of complement, histamine, and polymorphonuclear leukocytes. | 1975 | 1798 |
| the jumping mechanism of xenopsylla cheopis. ii. the fine structure of the jumping muscle. | the ultrastructure of the trochanteral depressor muscle of the oriental rat flea is described. it is shown to be similar to that of the tubular leg muscles of other insects except in the volume and arrangement of the sarcoplasmic reticulum. the sarcoplasmic reticulum occupies approximately 18% of the volume of the muscle fibres. it is in three configurations:a regular array of parallel tubules opposite the a-band, a collar of sacculi involved in the formation of the dyads at the edge of the a-ba ... | 1975 | 1805 |
| molecule--receptor specificity. | the specificity of binding between small molecules and macromolecular receptors may be studied by comparing theoretically calculated conformational potential energy surfaces of a series of chemically similar molecules which have a range of receptor binding energies and biological activities. in this way essential requirements for binding may be highlighted, including the necessity of the small molecule adopting, or passing through, conformations which are not at energy minima and not found eithe ... | 1975 | 1819 |
| the thermal transition of brain soluble proteins. | soluble rat brain proteins undergo a thermal reversible denaturation in the range of 20 degrees c -65 degrees c. the thermal transition as studied in 0.25 m sucrose solution, is associated with changes in the proteins ionization capacity by the lowering of the isoionic solution phfrom a value of 6.95 at 20 degrees c to 6.55 at 65 degrees c. the apparent enthalpy change delta h at the transition temperature (t=50 degrees c) is about 34 kcal, heat capacity delta cp about 1.75 kcal, and apparent en ... | 1975 | 1822 |
| normal arterial blood gases during experimental hypertriglyceridemia in the rat. | the possible effect of high concentrations of plasma triglycerides on arterial oxygen tension was investigated in rats by infusion of lymph chylomicrons or a soybean oil emulsion (intralipid). mean triglyceride concentrations were raised from 130 to 1454 mg/100 ml without statistically significant change in arterial oxygen tension, oxygen saturation, carbon dioxide tension, or ph. the small reduction in arterial oxygen tension, content, or saturation observed in earlier studies may have been due ... | 1975 | 1844 |
| survival of rats subjected to acute anemia at different levels of erythrocyte 2,3-diphosphoglycerate. | an experimental procedure was worked out in which rats were subjected to an exchange of erythrocytes, followed by acute anemia by means of hemodilution. one group of rats received erythrocytes with a high concentration of 2,3-diphosphoglycerate (dpg), and the other group was given erythrocytes with a low dpg concentration. the survival rate was equal in the two groups. irrespective of dpg concentration, the rats whose hemoglobin concentration reached the lowest level died. the rats that died wer ... | 1975 | 1846 |
| vascular and brain dopamine beta-hydroxylase activity in young spontaneously hypertensive rats. | dopamine beta-hydroxylase activity was higher in mesenteric vessels, adrenal glands, and serum of 3-week-old spontaneously hypertensive rats but lower in the locus coeruleus than it was in the control wistar-kyoto rats. the results support the concept that the nervous system is an important regulator of blood pressure. | 1976 | 1858 |
| the mechanism of the inhibition of iron absorption by tea. | previous human studies have shown that drinking tea during meals significantly inhibits the absorption of both food iron and medicinal iron. this study provides evidence from experiments with rats that the tannins in the tea are responsible for the inhibition, probably by forming non-absorbable complexes with the iron within the intestinal lumen. the molar ratio of tannin: iron is dependent on the ph, being 1:1 at ph 2,0 2:1 at ph 5,5 and 3:1 at ph 8,0. since tannins are present in many vegetabl ... | 1975 | 1862 |
| an investigation into the hepatic cytochrome p-450 catalysed metabolism of the anaesthetic fluroxene (2,2,2-trifluoroethyl vinyl ether). | the role of the different cytochromes p-450 in the metabolism of the anaesthetic agent fluroxene, and the mechanism of production of toxic effects seen after pre-treatment of the animals with pehnobarbital prior to anaesthesia, have been investigated. male rats were anaesthetized with fluroxene, or with 2,2,2-trifluroethyl ethyl ether, or with ethyl vinyl ether in an attempt to ascertain the in vivo toxic effects of the three anaesthetic agents. the resultant hepatic histology is reported. a stu ... | 1975 | 1863 |
| fluorocarbons and general metabolism in the rat, rabbit, and dog. | | 1975 | 1870 |
| the mechanism of action and treatment of palytoxin poisoning. | | 1975 | 1871 |
| effect of delta9-tetrahydrocannabinol on rat liver microsomal lipid peroxidation. | | 1975 | 1872 |
| isolation of different types of nematocyst from the cubomedusan chironex fleckeri. | | 1975 | 1877 |
| failure of carrageenan to affect graft-versus-host reactivity in the rat. | | 1975 | 1881 |
| the effect of tilorone on the local graft-versus-host reaction in rats. | | 1976 | 1883 |
| changes in the content of ribosomal rna and the activity of ribosomal rnaase in the brain under natural physiological conditions. | optimal activity of rnaase from brain ribosomal fraction was observed at ph 5.4 and ph 7.9. after alimentary and conditioned-alimentary stimulation content of rrna was significantly increased in brain, but the rnaase activity was decreased more than two-fold. after conditioned-alimentary inhibition content of rrna was slightly decreased as compared to experiments with alimentary and conditioned-alimentary stimulation, but it was distinctly higher than in control. as compared with alimentary stim ... | 1975 | 1900 |
| effect of the antibiotic d-cycloserine and its dimer on the activity of tyrosine aminotransferase in liver tissue of intact, adrenalectomized and hypophysectomized rats. | in a period of lowest day activity of tyrosine aminotransferase, within 6-8 days after bilatheral adrenalectomy, the enzyme activity was decreased by about 20% as compared with an adequate control. at the same time, within a day and seven days after hypophisectomy, in rat liver tissue the enzyme activity was increased, approximately two-fold as compared with the normal state. within four hrs after intraperitoneal administration into intact fasting rats at a dose of 2-2.5 g per 1 kg of body weigh ... | 1975 | 1901 |
| analysis of inhibition in pathways of nadp.h2 and nad.h2 oxidation in liver tissue microsomes. | microsomal complexes of electron transfer were resistant to typical inhibitors of mitochondrial pathway of electron transport. in oxidation of nadp.h2 there were at least three point of molecular o2 reduction: nadp.h2-specific flavoprotein, fe2+ participating in reactions of peroxidation of unsaturated fatty acids and cytochrome p-450. efficiency of cytochrome p-450 inhibitors could not be evaluated by polarography as in the pathway several sites of molecular o2 activation were observed. in oxid ... | 1975 | 1902 |
| the effect of hydrocortisone and insulin on the activity and isoenzyme of tyrosine-alpha-ketoglutarate transaminase in cytostructures of rat liver. | single administration of hydrocortisone or insulin into rats (body weight 200 g) and also combined treatment of the animals with the hormones at large doses caused a distinct increase in activities of anode and cathode isoenzymes of tyrosine-alpha-ketoglutarate transaminase in soluble fraction; total activity of the enzyme was also increased in mitochondria of rat liver tissue. | 1975 | 1903 |
| modification of the adjuvans arthritis by carrageenin, compound 48/80, histamine- and serotonin antagonists, non-steroid antiphlogistics as well as protease inhibitors and their possible relations to inflammation mediators. | 1. injections of carrageenin (1,25 mg/kg i.v.) from the 1st to the 3rd day and then each 2nd or 3rd day inhibited paw swelling in adjuvant arthritis of the rat during the time of treatment. injections from the 11th to the 15th day were ineffective. the level of plasma kininogen was slightly decreased but the total complement serum level was significantly lowered. 2,5 and 3 mg carrageenin/kg respectively were toxic after repeated injections. after a single administration the levels of plasma kini ... | 1975 | 1954 |
| tremorigenic effect of alpha, alpha - dipyridyl in the rat. | | 1975 | 1955 |
| histological study of host reactions to allograft of the tooth and the subcutaneous insertion of dental prosthetic materials. | | 1975 | 1958 |
| influence of changes in arterial pco2 on cerebral blood flow and cerebral energy state during hypothermia in the rat. | in order to study the relationship between arterial pco2 and cerebral blood flow (cbf) in hypothermia, the body temperature of artifically ventilated rats was decreased to 22 degreesc, and changes in cbf were evaluated from arteriovenous differences in oxygen content (avdo2) at paco2 values of 15, 30, 40 and 60 mm hg. the results were compared to those obtained at normal body temperature (37 degrees c) over the paco2 range 15-60 mm hg. separate experiments were performed to evaluate cbf and cmro ... | 1975 | 1961 |
| neurohistological and histochemical observations on the lung of rattus rattus rufescens (indian black rat). | the intrinsic innervation of the lungs (right and left) has been studied by the cholinesterase technique, considering the effect of various ph, incubation periods and temperatures. cholinergic innervation dominated. the peribronchial ganglia, large, medium-sized and irregular-shaped, rounded and small, showed a positive cholinesterase reaction. maximum che activity was noticed in the bronchi and their branches and on the periphery of the alveoli. | 1975 | 1962 |
| regulation of enzyme activity by glucagon: increased hormonal activity of iodinated glucagon. | | 1975 | 1975 |
| classification and biological distribution of histamine receptor sub-types. | the distribution and classification of histamine receptors in mammalian and avian tissues have been summarized in tables 1-4. it is evident that histamine receptors are present on a number of morphologically distinct cell types and the proportion of cells bearing h1- and h2-receptors varies not only with the species but also with the cell source. the pharmacological receptors mediating mepyramine-sensitive histamine responses have been defined as h1-receptors. receptors mediating mepyramine-resi ... | 1975 | 1979 |
| identification of t. brucei-subgroup strains isolated from game. | several t. brucei-subgroup strains isolated from game were investigated with the blood incubation infectivity test (biit) and in human volunteers. original isolates and their clones derivatives were tested. in order to check the validity of the biit, volunteer tested clones were used under modified biit conditions. inoculation of different trypanosome strains into volunteers yielded positive parasitaemia for original isolates from lion, hyaena, and coke's hartebeest. changing antibody titers dur ... | 1975 | 1983 |
| effect of ph on ionic exchange and function in rat and rabbit myocardium. | the effects of ph variation on ionic exchange and mechanical function were studied in the arterially perfused rat and rabbit septa. the ph and pco2 of the control perfusate were 7.40 and 39 mmhg, respectively. in the rabbit septum a metabolic acidosis (ph equals 6.82, pco2 equals 39 mmhg) caused a loss of 16% of control tension in 12 min. na+ and k+ exchange were unaltered. a comparable respiratory acidosis (ph equals 6.81, pco2 equals 159 mmhg) caused a 51% loss of tension in 2 min. na+ exchang ... | 1975 | 2014 |
| effect of combined use of steroid preparations with pyrroxane on the gonadotropic function of the hypophysis. | | 1975 | 2025 |
| age related effects of furosemide in the rat. | furosemide (6 mg/kg i.p.) increases the renal excretion of water, osmotic active substances, sodium and chloride in 5 to 33 day old rats more than in adults. the dose-response-relations are the same in rats of all age groups: 6 mg/kg of furosemide i.p. are very effective, an increase in dose to 30-60 mg/kg i.p. is not followed by a significantly higher efficacy. the increase in the renal excretion of potassium, hydrogen ions, ammonium and hydrogen carbonate by furosemide is also small in young r ... | 1975 | 2118 |
| calcitonin-sensitive adenylate cyclase in rat renal tubular membranes. | 1. renal tubular membranes from rat kidneys were prepared, and adenylate cyclase activity was measured under basal conditions, after stimulation by naf or salmon calcitonin. apparent km value of the enzyme for hormone-linked receptor was close to 1 x 10(-8) m. 2. the system was sensitive to temperature and ph. ph was found to act both on affinity for salmon calcitonin-linked receptor and maximum stimulation, suggesting an effect of ph on hormone-receptor binding and on a subsequent step. 3. kcl ... | 1975 | 2153 |
| stabilization of rat liver tyrosine aminotransferase by tetracycline. | rat liver tyrosine aminotransferase was purified 200-fold and an antiserum raised against it in rabbits. 2. hepatic tyrosine aminotransferase activity was increased fourfold by tyrosine, twofold by tetracycline, 2.5-fold by cortisone 21-acetate and ninefold by a combination of tyrosine and cortisol administered intraperitoneally to rats. 3. radioimmunoassay with 14c-labelled tyrosine aminotransferase, in conjunction with rabbit antiserum against the enzyme, revealed that cortisol stimulates the ... | 1975 | 2154 |
| induction of dt-diaphorase by 2,3,7,8-tetrachlorodibenzo-p-dioxin (icdd). | | 1976 | 2167 |
| fluroxene (2,2,2-trifluoroethyl vinyl ether) mediated destruction of cytochrome p-450 in vitro. | | 1975 | 2170 |
| covalent binding of trans-stilbene to rat liver microsomes. | | 1975 | 2171 |
| brain enzyme levels during intraperitoneal injections of ammonium acetate. | | 1975 | 2172 |
| modifications of citrate and isocitrate metabolism in liver mitochondria of ethanol-fed rats. | | 1975 | 2174 |
| the effects of 5,6-dihydroxytryptamine on the transport mechanisms of various neurotransmitters or their precursors at the synaptosomal level in the rat mesencephalon. | | 1975 | 2175 |
| inhibition of hepatic mixed-function oxidase activity in vitro and in vivo by various thiono-sulfur-containing compounds. | | 1975 | 2176 |
| on the mechanism of hypothalamic adrenergic mediation. histochemical research. | | 1975 | 2270 |
| effect of aflatoxin b1 on pyridine nucleotides and nadp linked dehydrogenases. | the effect of a single interaperitoneal injection (6 mg/kg body weight) of aflatoxin b1 in propylene glycol on pyridine nucleotides and ndp linked dehydrogenases was studied 24 h after administration of the toxin. the liver showed a decrease in total proteins and pyridine nucleotides though levels of nadp and nadph remained unchanged. levels of nad and nadh were decreased. the activities of hepatic of hwprix of hepatic malate dehydrogenase (mdh) and isocitrate dehydrogenase (icdh) were not alter ... | 1975 | 2275 |
| chromatin-bound protease: degradation of chromosomal proteins under chromatin dissociation conditions. | a chromatin-bound protease, active in 2 m nacl-5 m urea or 5 m urea alone, was demonstrated in rat liver, kidney, testes, brain, rabbit bone marrow, chicken reticulocyte, and ehrlich ascites chromatin. chicken erythrocyte chromatin did not possess any detectable proteolytic activity in salt and urea. the proteolytic activity of rat liver chromatin in salt and urea was found to be independent of the methods of chromatin preparation. the protease can be inhibited by the serine specific reagents ph ... | 1976 | 2280 |
| isolation and characterization of the brush border fraction from newborn rat renal proximal tubule cells. | a renal brush border fraction was isolated from newborn sprague-dawley rats, and its morphological and enzymatic characteristics were studied in comparison to that from the adult. definite microvillar structures are seen by electron microscopy, and border preparations from the newborn are enriched in known marker enzymes. though morphological development is more advanced and enzyme specific activities are greater in the adult, polyacrylamide gel electrophoresis of membrane proteins reveals no si ... | 1976 | 2293 |
| glial fibrillary acidic protein from bovine and rat brain. degradation in tissues and homogenates. | compared with human material glial fibrillary acidic protein isolated from bovine, rat and mouse brain was remarkably homogeneous and migrated as a single band at 54 000 mol. wt. on sodium dodecyl sulfate gel electrophoresis. the protein was extremely susceptible to proteolysis and lower molecular weight components were invariably isolated together with the major species when the brain was not rapidly frozen. further degradation of the 54 000 mol wt. polypeptide in bovine tissues incubated at 24 ... | 1976 | 2294 |
| partial purification and characterization of post-proline cleaving enzyme: enzymatic inactivation of neurohypophyseal hormones by kidney preparations of various species. | the inactivation of the neurohypophyseal hormones arginine vasopressin and oxytocin, both 14c-labelled in the c-terminal glycine residue, by enzymes present in kidney homogenates of various species has been investigated, and some of the enzymes responsible have been partially purified and characterized. the leu-gly peptide bond of oxytocin is generally most effectively cleaved by kidney homogenates, although with certain species enzymic activity hydrolyzing the pro-leu bond is significant. degra ... | 1976 | 2300 |
| adenosine phosphyorylase activity as distinct from inosine-guanosine phosphorylase activity in sarcoma 180 cells and rat liver. | adenosine phosphorylase (ec 2.4.2.-) activity present in sarcoma 180 cells grown in culture and in rat liver, is shown to be distinct from inosine-guanosine phosphorylase by several criteria: (a) treatment of sarcoma 180 cell extract with p-chloromercuribenzoate inhibited the two activities to a different extent, (b) adenine selectively protected the adenosine phosphorylase activity of sarcoma 180 and rat liver extract against heat inactivation, while hypoxanthine selectively protected inosine-g ... | 1976 | 2301 |
| mechanism of active shrinkage in mitochondria. ii. coupling between strong electrolyte fluxes. | 1. addition of succinate to valinomycin-treated mitochondria incubated in kcl causes a large electrolyte penetration. the process depends on a steady supply of energy and involves a continuous net extrusion of protons. rates of respiration and of electrolyte penetration proceed in a parallel manner. 2. a passive penetration of k+ salt of permeant anions occurs in respiratory-inhibited mitochondria after addition of valinomycin. addition of succinate at the end of the passive swelling starts an a ... | 1976 | 2314 |
| a possible mechanism of the generation of singlet molecular oxygen in nadph-dependent microsomal lipid peroxidation. | a simplified system, consisting of nadph, fe3+-adp, edta, liposomes, nadph-cytochrome c reductase and tris - hcl buffer (ph 6.8), has been employed in studies of the generation of singlet oxygen in nadph-dependent microsomal lipid peroxidation. the light emitted by the system involves 1deltag type molecular oxygen identifiable by its characteristic emission spectrum and its behavior with beta-carotene. the generation of another excited species (a compound in the triplet state) could be demonstra ... | 1976 | 2317 |
| immunological similarity between nadh-cytochrome b5 reductase of erythrocytes and liver microsomes. | in a number of animal species soluble nadh-cytochrome b5 reductase of erythrocytes was compared with membrane-bound nadh-cytochrome b5 reductase of liver microsomes by using an antibody to purified nadh-cytochrome b5 reductase from rat liver microsomes. the results obtained indicated clearly that they are immunologically very similar to each other. the data with erythrocyte ghosts suggested that cytochrome b5 and nadh-cytochrome b5 reductase are also present in the ghost. | 1976 | 2319 |
| various properties of the creatine transport system and the location of creatine kinase in skeletal muscle mitochondria. | water and creatine contents were studied in rat skeletal muscle mitochondria after their 5 min. incubation in creatine solutions, ph 7.2 or 8.4. the content of water and creatine in mitochondria was found to be higher at ph 8.4, than at ph 72, the creatine content correlated with the water content. structural creatine analogues, containing aminogroups with pka greater than or equal to 9.5 or carboxyl groups, inhibited the infusion of creatine into mitochondria more strongly than substances havin ... | 1975 | 2328 |
| assessment in the guinea-pig ileum and mouse vas deferens of benzomorphans which have strong antinociceptive activity but do not substitute for morphine in the dependent monkey. | 1 four benzomorphans which have potent antinociceptive activity in the hot-plate and writhing tests in the mouse but do not suppress or precipitate withdrawal symptoms in the morphine-dependent monkey, have been examined for their pharmacological actions in the guinea-pig ileum and mouse vas deferens. 2 in the guinea-pig ileum their agonist potencies are 1.5 to 400 times greater than that of normorphine of morphine whereas in the mouse vas deferens their potencies relative to morphine are 0.3 to ... | 1975 | 2359 |
| letter: massive intoxication with metoprolol. | | 1976 | 2365 |
| ph-dependent solubilization of brain mitochondrial hexokinase: developmental considerations. | | 1975 | 2368 |
| value of the "gastric chamber", new technic performed ex vivo, for the study of the gastric mucosa of the rat. | the "gastric chamber" technique, performed in the anaesthetised rat, enables the study of gastric mucosal fragility induced by doses of phenylbutazone, which do not themselves cause ulceration or exulceration. the perfusion of buffered solution at ph 2-8 into the gastric chamber shows that prior oral administration of phenylbutazone 50 mg/kg increases the fragility of the mucosa. the optimal delay separating this administration from the time of experimentation is 6 hours. the effects seen are es ... | 1975 | 2370 |
| ciguatera: neurophysiologic and histoenzymologic studies of several fractions of ciguatoxic extracts. | two fractions of ciguatoxic extracts were isolated by chromatography. the first showed anticholinesterasic properties, while the other acted directly on the muscular fibre. these findings were histoenzymologically confirmed. controls with non-toxic extracts of fishes from the coral benthos reinforce the theory of the ecological origins of ciguatoxins. | 1975 | 2376 |
| monoamine storage sites in the rat superior cervical ganglion following synthesis inhibition. | monoamine storage sites in paraganglionic (pg-) cells of the rat superior cervical ganglion were investigated by electron and fluorescence microscopy following treatment with p-chlorophenylalanine (pcpa), disulfiram or guanethidine respectively. dense core vesicles in pg-cells are significantly decreased (p less than 0.001) in number following pcpa, and in the majority of these cells following disulfiram and guanethidine. however in a minor portion of pg-cells the latter agents cause an increase ... | 1976 | 2382 |
| ultracytochemistry of the synaptic ribbons in the rat pineal organ. | the synaptic complexes of the rat pinealocytes are neither cholinergic nor adrenergic. in the synaptic vesicles, a neurotransmitter carrier substance of lipid nature reacting with oso4-zn i2 mixture (similar to that present in both cholinergic and adrenergic vesicles) was not found. in addition, there were no indications of glucose-6-phosphatase or thiamine-pyrophosphatase activity in the synaptic vesicles. thus, it appears that the synaptic vesicles do not originate from the rough or smooth end ... | 1976 | 2383 |