| spontaneous lesions and parasites of the mongolian gerbil, meriones unguiculatus. | four-hundred-eighty mongolian gerbils, meriones unguiculatus [uclp:(mon)], most of which were experimentally infected with filarial worms, were examined for spontaneous lesions. previously unrecognized lesions included cutaneous squamous cell carcinoma, duodenal adenocarcinoma, malignant blue nevus, hepatic choleangiocarcinoma, malignant hemangiopericytoma of the uterus, ovarian teratoma, chronic interstitial nephritis, renal cortical retention cysts, splenic hemangiomas, and various histologic ... | 1975 | 1207042 |
| what triggers seizures in the gerbil, meriones unguiculatus? | | 1975 | 1207388 |
| the effect of vitamin b6 supplements on development of seizures in the gerbil, meriones unguiculatus. | | 1975 | 1207402 |
| influence of neonatal androgen on the display of territorial marking behavior in the gerbil. | the effect of the presence or absence of androgen during the neonatal period on territorial marking behavior in the mongolian gerbil was studied. scent marking frequency was 20-40 fold greater in males than in females. gonadectomy depressed marking in males but not in females. testosterone propionate (tp) therapy completely restored marking in male but increased marking in intact and ovariectomized females to only one fourth that in males. genetic males castrated within 2 days postpartum did not ... | 1975 | 1208669 |
| a morphological study of the lateral olfactory areas of the telencephalon in the mongolian gerbil, meriones unguiculatus. | this study concerns the morphological description of the nuclear groups and fiber tracts in the olfactory areas in the lateral wall of the hemisphere of the gerbil. the sense of olfaction is assumed to play an important role in the gerbil's behavior (see vol. 15, sect. 4). the hippocampal formation, amygdala and corpus striatum are well-developed and differentiated structures in the gerbil. these areas receive either direct or indirect olfactory connections through such pathways as the medial an ... | 1975 | 1214053 |
| [the effect of cold adaptation on total gaseous metabolism and tissue respiration in gerbils]. | short-term adaptation to cold (-17-19 degrees) results in evident changes of energy metabolism of gerbiles. in cold-adapted meriones unguiculatus, tissue oxygen consumption increases in all the tissues investigated. in m. tamariscinus, respiratory rate increased only in the cardiac muscle, whereas that in other organs and muscles remained unaffected. in contrast to these two cold-resistant species, m. erythrourus is less resistant to cooling. in the latter case, no changes were observed in total ... | 1975 | 1217308 |
| time of implantation in the mongolian gerbil (meriones unguiculatus) and its hormonal requirements. | | 1975 | 1218195 |
| effects of olfactory bulb ablation and androgen on marking and agonistic behavior in male mongolian gerbils (meriones unguiculatus). | male mongolian gerbils, selected for high marking frequency, were paired with male opponents, and marking and fighting behavior were recorded. animals then underwent castration, bilateral bulbectomy, unilateral bulbectomy, the combined operations, or a sham operation; and their behavior was again observed. all operated animals showed drastic reduction in both marking and aggressive encounters. injections of testosterone propionate (tp) produced complete restoration of marking in castrates, but n ... | 1975 | 1238441 |
| histogenesis of tumors from the nasal cavities induced by diethylnitrosamine. | chronic subcutaneous (s.c.) or single intravenous (i.v.) injections of diethylnitrosamine (den) to gerbils (meriones unguiculatus) led to the induction of carcinomas of the nasal cavities in a high incidence. these neoplasms were multifocal in origin, frequently showing mixed cellular patterns of the following cell types: large cuboidal cells, nonciliated columnar cells, ciliated columnar cells, small cells, and squamous epithelial cells. no sensory cells of the olfactory mucosa or neurofibrilla ... | 1976 | 1247964 |
| visual discrimination in the mongolian gerbil (meriones unguiculatus) as a function of age. | ten young (8 weeks) and 10 old (26 weeks) male gerbils were tested for the acquisition of a visual discrimination task. ss were given 10 daily six-trial sessions in a t-maze with a food reinforcement being associated with horizontal or vertical stripes. the older ss failed to learn the discrimination habit, and the young ss steadily improved over the 10 sessions. | 1976 | 1255144 |
| development of two markers for identification of lymphocyte subpopulations in the jird (meriones unguiculatus). | | 1976 | 1255377 |
| spontaneous and drug-induced rotation (circling behavior) in the mongolian gerbil (meriones unguiculatus). | | 1976 | 1259678 |
| effects of uterus and prostaglandin f2alpha on corpora lutea in mongolian gerbils and guinea pigs. | one or both uterine horns were removed on postpartum day 6 day 1=parturition in pseudopregnant gerbils. on dy 16, the corpora lutea (c) in unilaterally hysterectomized gerbils were smaller (p less than 0.05) in the ovary adjacent to an intact horn than in the ovary adjacent to a removed horn. the cl were smaller in uterine-intact than in completely hysterectomized gerbils. i n another experiment, the cl were smaller (p less than 0.05) in pseudopregnant gerbils given a single intrauterine injec ... | 1976 | 1275344 |
| effect of colchicine and estradiol on mammotrophs and chromophobes in the mongolian gerbil anterior pituitary gland. | | 1976 | 1278587 |
| ischemia-induced changes in the immunoreactivity for endothelin and other vasoactive peptides in the brain of the mongolian gerbil. | immunoreactivity for vasoactive peptides [endothelin (et); calcitonin gene-related peptide (cgrp); atrial natriuretic peptide (anp); neuropeptide y (npy)] was investigated in nervous tissue of mongolian gerbils in which the common carotid artery (cca) was temporarily occluded (30 min-4 h) on one side, provoking transient unilateral ischemia at the forebrain level. observations were carried out in a group of animals that were perfused promptly after cca reopening, and in a group of animals that w ... | 1992 | 1282982 |
| the ontogenesis of sensorimotor reflexes in the mongolian gerbil meriones unguiculatus. | the ontogeny of a number of sensorimotor reflexes has been studied in the mongolian gerbil. in contrast to a number of other mammals, the gerbil has relatively long and strong hindlimbs but small forelimbs, indicating their different importance for a number of locomotor acts, and during the developmental period studied, the hindlimbs grow at a much faster rate than the forelimbs. the following sequence of appearance and maturation of the reflexes was observed: rooting, forelimb hopping, surface ... | 1992 | 1294193 |
| experimental renal papillary necrosis in the mongolian gerbil (meriones unguiculatus). | sequential light microscopic and ultrastructural examination of kidneys from male and light microscopic examination of female mongolian gerbils given 250 mg 2-bromoethylamine hydrobromide (bea)/kg body weight ip were performed. in addition, male mongolian gerbils were treated with both bea and ip injections of either water, dimethyl sulfoxide, piperonyl butoxide, or reserpine. light microscopic renal lesions in male mongolian gerbils progressed from congestion of the vasa recta of the proximal i ... | 1992 | 1295065 |
| [etiological mechanisms of population homeostasis in mongolian gerbils (meriones unguiculatus)]. | | 1992 | 1301089 |
| a mammalian model of optic-flow utilization in the control of locomotion. | gibson (1966, 1979) and lee (1976) have described the potential usefulness of optic-flow information for the control of locomotion. one variable that might be particularly important for an animal approaching a target is time-to-collision, which lee argues is most efficiently specified by the tau margin (the inverse of the relative rate of expansion of the target image on the retina). in humans, most empirical studies of optic flow have required perceptual judgements or have examined catching/int ... | 1992 | 1301371 |
| alterations in the gamma-aminobutyric acid-gated chloride channel following transient forebrain ischemia in the gerbil. | the role of inhibitory neurotransmission in selective neuronal degeneration after transient forebrain ischemia was studied by binding of t-[35s]butylbicyclophosphorothionate ([35s]tbps) to the gamma-aminobutyric acid (gaba)-gated chloride channel and measurement of gabaa receptor function in mongolian gerbil brain. [35s]tbps binding to the hippocampus, striatum, and cortex quantified by autoradiography and muscimol-stimulated 36cl- uptake in synaptoneurosomes of the same regions were examined 1, ... | 1992 | 1309565 |
| postischemic binding of [3h]phorbol 12,13-dibutyrate and [3h]inositol 1,4,5-trisphosphate in the gerbil brain: an autoradiographic study. | postischemic alteration of second messenger systems was investigated in the mongolian gerbil, utilizing [3h]phorbol 12,13-dibutyrate and [3h]inositol 1,4,5-trisphosphate receptor autoradiography. transient ischemia was induced for 10 min, and animals were allowed to survive for various recirculation periods of up to one month. [3h]phorbol 12,13-dibutyrate binding in selectively vulnerable areas showed no significant change 1-24 h after ischemia except for a transient decline in a few regions. th ... | 1992 | 1311818 |
| ion transport by primary cultures of mongolian gerbil middle ear epithelium. | the transport properties of mongolian gerbil middle ear epithelial cells grown in primary culture were studied. these cells formed polarized monolayers that exhibited domes on nonporous supports. on porous supports, monolayers developed an apical-negative transepithelial electric potential difference (vt = -37.2 +/- 2.7 mv) and a transepithelial resistance (rt = 519 +/- 56 omega.cm2). the short-circuit current equivalent (ieq) was 62.4 +/- 6.2 microa/cm2 (mean +/- se, n = 15). na+ and cl- accumu ... | 1992 | 1313643 |
| multiparametric evaluation of brain functions in the mongolian gerbil in vivo. | we have developed the multiprobe assembly (mpa) by which metabolic, ionic and electrical activities can be monitored from the surface of the brain. in the present study we included optical fibers for the monitoring of intracapillary hemoglobin oxygenation by use of the erlangen microlight guide spectrophotometer (empho-i) from the surface of the gerbil brain. the newly developed mpa provides simultaneous information about oxygen delivery (oxydeoxy hb), tissue po2 level, as well as the intracellu ... | 1992 | 1339223 |
| immunoreactivity of astroglia in the hippocampus of the mongolian gerbil during short survival following brief ischemia. | mongolian gerbils subjected to 5-min cerebral ischemia by common carotid artery ligation were decapitated after 24, 48, 72 and 96 h of survival to investigate the immunoreactivity of astroglia in the hippocampus. the sections from formalin-fixed, paraffin-embedded brains were stained histologically and with abc method (hsu et al. 1981). control animals (normal and shame-operated) presented positive gfap immunostaining in corpus callosum, in subventricular regions, in temporal subcortical white m ... | 1992 | 1340915 |
| effects of aging on signal transmission and transduction systems in the gerbil brain: morphological and autoradiographic study. | the mongolian gerbil was used as a model of aging because of its relatively short lifespan, genetic homogeneity and the fact that data had been collected previously. furthermore, gerbils have been widely used in biomedical investigations of stroke and epilepsy. age-related differences in signal transmission and transduction systems were investigated in brains of three-, 11- and 21-month-old gerbils by morphological and in vitro receptor autoradiographic studies. morphometric analysis revealed a ... | 1992 | 1347408 |
| distribution and characterization of different molecular products of pro-somatostatin in the hypothalamus and posterior pituitary lobe of the mongolian gerbil (meriones unguiculatus). | antisera raised against various synthetic peptide fragments of the pro-somatostatin molecule were used to visualize immunohistochemically the distributions of different pro-somatostatin fragments in the hypothalamus and posterior pituitary of the mongolian gerbil. to define the nature of the immunoreactive somatostatin-related molecular forms, gel chromatography combined with radioimmunoassays of hypothalamic and posterior pituitary extracts was performed. within the hypothalamus, only trace amo ... | 1992 | 1347564 |
| methacrylonitrile: in vivo metabolism to cyanide in rats, mice, and gerbils. | methacrylonitrile (mean), a widely used industrial chemical, is metabolized to cyanide in rats, mice, and gerbils. cyanide levels following oral administration of 0.5 or 1 ld50 dose of mean were determined in blood and organs of treated animals. male mongolian gerbils were 50-fold more sensitive to mean than sprague-dawley rats and about 5-fold more sensitive than were albino-swiss mice. the signs of mean toxicity were typically those of cyanide-related central nervous system poisoning in all th ... | 1992 | 1352204 |
| intrinsic and drug-induced seizures of adult and developing gerbils. | seizures elicited by posture change and intraperitoneal administration of convulsants were studied ontogenetically in the mongolian gerbil (meriones unguiculatus). in posture change, the first signs of seizure appeared after age 6 weeks with maximal frequency at 8-9 weeks. adults developed complex, but stereotyped, seizures. facial twitch was followed by the generalized convulsion, further progressing to trembling of the limbs and then kicking of the hindlimb (full seizure) after 55 days of age. ... | 1992 | 1352421 |
| immunity to hantavirus challenge in meriones unguiculatus induced by vaccinia-vectored viral proteins. | vaccinia virus recombinants were constructed that incorporated genomic sequences coding for the nucleoprotein (n) and glycoproteins (g1 and g2) of the hantavirus r22 strain isolated from a rat in china, and designated as rnv and rmv9, respectively. the proteins expressed by rnv and rmv9 were identified by radioimmunoprecipitation and indirect immunofluorescence assay using a panel of monoclonal antibodies and polyclonal immune sera, and were found to be antigenically indistinguishable from authe ... | 1992 | 1359802 |
| the effects of age on the pharmacokinetics and biotransformation of theophylline in vivo and in vitro in the mongolian gerbil (meriones unguiculatus). | the effect of post maturational aging on the in vivo disposition of theophylline was examined in the mongolian gerbils (meriones unguiculatus) aged 30-39 (old), 12-18 (middle-aged) and 3 (young) months following a 20 mg/kg i.p. dose. biotransformation of theophylline was also examined in liver microsomes from non-induced and 3-methylcholanthrene induced gerbils. analysis of theophylline plasma kinetics showed decreased clearance, increased half-life and increased volume of distribution in old vs ... | 1992 | 1365843 |
| characterization of indole-2-carboxylate derivatives as antagonists of n-methyl-d-aspartate receptor activity at the associated glycine recognition site. | we have synthesized a series of indole-2-carboxylate derivatives and, with the use of radioligand binding, electrophysiological techniques and an in vivo transient bilateral carotid occlusion model of ischemic damage known to be sensitive to nmda antagonists, have evaluated the indole-2-carboxylate derivatives ability to inhibit n-methyl-d-aspartate (nmda) receptor activity through the associated glycine modulatory site. by using [3h]glycine to label this modulatory site, we found that the compo ... | 1992 | 1386886 |
| natural echinococcus multilocularis infection in a norway rat, rattus norvegicus, in southern hokkaido, japan. | forty-two rats, rattus norvegicus, captured at a garbage dump in southern hokkaido, japan, were examined, and one was found to be infected with echinococcus multilocularis. the lesions were found in the liver, lung, mesenteric lymph nodes, greater omentum and also free in the abdominal cavity. no necrosis was observed in any of the lesions, and inflammatory reactions were mild. protoscoleces were observed in the large liver cysts. a homogenate of these cysts, when transplanted into the abdominal ... | 1992 | 1399254 |
| [effect of indomethacin on delayed neuronal death of hippocampal ca1 sector in gerbil under different levels of controlled cranial temperatures]. | effect of indomethacin on post-ischemic changes of ca1 neurons was studied in the hippocampus of the mongolian gerbil. the gerbil was employed because due to poor development of posterior communicating artery ischemia could be easily induced in the forebrain simply by occluding bilateral common carotid arteries. indomethacin (5 mg/kg, i.p.) was administered 30 min before the occlusion. the occlusion lasted for 5 divided into four groups. in one group, the temperature was not controlled. in the r ... | 1992 | 1400907 |
| significance of nerve growth factor content levels after transient forebrain ischemia in gerbils. | involvement of nerve growth factor (ngf) in the pathogenesis of delayed neuronal death (dnd) of ca1 neurons in the hippocampus has been suggested. we measured regional changes in the content of tissue ngf of the hippocampus in the mongolian gerbil after 5 min forebrain ischemia. the ngf content was found to decrease significantly in the ca3 and dentate regions by 32% two days after ischemia. by contrast in the ca1 region, the level of ngf became significantly elevated by 50% two weeks after isch ... | 1992 | 1407681 |
| 5-ht1a and 5-ht2 receptors mediate discrete behaviors in the mongolian gerbil. | although the ability of agonists at specific serotonin (5-ht) receptor subtypes to induce distinct behaviors has been well documented in the rat, similar studies have not been reported in the mongolian gerbil. we have found that the 5-ht1a/5-ht2 agonist 5-methoxy,n-n dimethyltryptamine (5-meodmt) (0.5-8 mg/kg, sc), the specific 5-ht1a agonist 8-hydroxy(di-n-propylamino)tetralin (8-oh-dpat) (0.125-16 mg/kg, sc), and the 5-ht precursor l-5-hydroxytryptophan (l-5-htp) (100-250 mg/kg, sc) all elicit ... | 1992 | 1409796 |
| an automated method for recording scent marking in mongolian gerbils. | a device for the automated recording of scent-marking events in mongolian gerbils (meriones unguiculatus) is described. the method uses minute temperature changes occurring at the surface of marked objects to detect scent marking. these events are recorded by a computer together with the exact time and the location of the marked object. the data obtained with this temperature-sensitive recording method correlate well with data obtained in parallel by human observers. the measurement of the diurn ... | 1992 | 1409937 |
| estimation of the total number of neurons in different brain areas in the mongolian gerbil: a model of experimental ischemia. | the quantitative stereological method is applied to a study of the number of neurons in three different areas in the brains of an animal model, the mongolian gerbil. the simplicity and accuracy of the method is emphasized. the usefulness of the method and the model is mentioned especially focusing on the major disabling disease in the western world today, cerebrovascular disorders. some results are presented to give an idea of the maximum number of neurons in these animals within the delineation ... | 1992 | 1414259 |
| quantitative neuropathology in epilepsy. | counting of neurons has brought new insight to the mechanism of epilepsy. the reduction in purkinje cells and neuron loss in hippocampus are related to generalized convulsions in man. generalized convulsions provoked by electric shock in rats do not result in neuron loss. however, mongolian gerbils from seizure-susceptible strains with "spontaneous" seizures of various types, have a reduced number of h1-neurons and purkinje cells after only a restricted number of seizures of any type. loss of ne ... | 1992 | 1414262 |
| heparin-containing mast cells in the jejunal mucosa of normal and parasitized mongolian gerbils, meriones unguiculatus. | histochemical stainability of mast cells in the small intestine of mongolian gerbils, meriones unguiculatus, was examined before and after infection with nippostrongylus brasiliensis, a well-known intestinal helminth inducing intestinal mastocytosis in rats and mice. mast cells seen in the small intestine of mongolian gerbils were exclusively formalin-resistant and were strongly stained by berberine sulfate, regardless of whether the animals were normal or infected with n. brasiliensis. furtherm ... | 1992 | 1422268 |
| middle ear development. iii: morphometric changes in the conducting apparatus of the mongolian gerbil. | middle-ear structural ontogeny was examined in 12 age groups of mongolian gerbils between 2 and 42 days after birth. measurements of tympanic membrane surface area; depth of the tympanic membrane cone; the lengths of the malleus and incus long processes; and stapes footplate, annular space, and oval window areas were obtained using video micrographs and computer digitization techniques. the incus long process matured first at 3.5 days after birth, while the pars flaccida surface area was the las ... | 1992 | 1429261 |
| projections to the medial superior olive from the medial and lateral nuclei of the trapezoid body in rodents and bats. | in this study we present direct evidence of axonal projections from both the medial and lateral nuclei of the trapezoid body to the medial superior olive. projections were traced by intracellularly labeling cells and axons in a tissue slice preparation of two rodent species, mus musculus and meriones unguiculatus and two bat species, eptesicus fuscus and pteronotus parnellii. the main axon of most principal cells in the medial nucleus of the trapezoid body gives off one or more collateral branch ... | 1992 | 1430335 |
| demonstration of dopamine-immunoreactive cells in the proximal convoluted tubule of gerbil (meriones unguiculatus) kidney. | we investigated dopamine immunoreactivity in the kidney of gerbils (meriones unguiculatus). for that purpose a sensitive and selective antibody against glutaraldehyde-conjugated dopamine was applied. dopamine-immunoreactive cells were found in the epithelium of the proximal convoluted tubule, where these cells revealed a typical segment-like distribution pattern. dopamine-immunoreactive precipitates were small and concentrated at the apical pole of the labeled cells. this study has directly iden ... | 1992 | 1431057 |
| ultrastructural localization of calcium in mechanoreceptors of the oral mucosa. | cytochemical localization of ca2+ in meissner corpuscles and merkel cell-neurite complexes in the palatine mucosa of the mongolian gerbil was studied by a combined oxalate antimonate-microwave irradiation procedure. the reaction products obtained were identified as calcium antimonate by egta solubility and x-ray microanalysis. meissner corpuscles in the normal palatine rugae could be roughly classified into three types by amount and localization of ca2+. type i corpuscles were characterized by a ... | 1992 | 1431996 |
| the prolonged presence of glia-derived nexin, an endogenous protease inhibitor, in the hippocampus after ischemia-induced delayed neuronal death. | the presence of glia-derived nexin and glia fibrillary acidic protein (gfap) was investigated in the hippocampus of mongolian gerbils (meriones unguiculatus) after transient forebrain ischemia. bilateral clamping of the common carotid arteries for 7 min resulted in selective degeneration of ca1 pyramidal cells after a delay of three to four days, the so-called delayed neuronal death. immunoreactivity for glia-derived nexin was found in astrocytes of all ca1 layers and was detectable until day 90 ... | 1992 | 1436472 |
| high resistance of cultured mongolian gerbil cells to x-ray-induced killing and chromosome aberrations. | the mongolian gerbil (meriones unguiculatus) is known to be one of the most radioresistant animals. we have examined the x-ray sensitivity of normal diploid fibroblasts from mongolian gerbil embryos compared with those of cultured embryo cells obtained from various laboratory animals and a normal human. there was a wide difference in x-ray sensitivity for cell killing among different mammalian species. the d0 values for mongolian gerbil cells ranged from 2.08 to 2.28 gy, values which are twice a ... | 1992 | 1438686 |
| prediction of cerebral ischemia by ophthalmoscopy after carotid occlusion in gerbils. | the mongolian gerbil provides a unique model of unilateral focal cerebral ischemia because of the lack of posterior communicating arteries in all gerbils as well as an absence of an anterior communicating artery in approximately 20% of the gerbil population. it is unclear how to identify unequivocably the subpopulation of animals that would suffer a severe focal cerebral ischemia after unilateral carotid occlusion. | 1992 | 1440707 |
| [developmental study of the ventral scent gland of the mongolian gerbil]. | male and female in bred mongolian gerbils aged 4, 5, 10, and 20 weeks were examined for the presence of a ventral scent gland macroscopically and histologically. it was found in about half of the gerbils aged 4 weeks and in all of the gerbils aged over 5 weeks. in adult male gerbils it weighed three times as much as in females. the ventral scent gland exhibited a sebaceous-like structure which consists of giant glandular cells with small vacuoles in the cytoplasm and the glandular cells displaye ... | 1992 | 1451767 |
| one-tone suppression in the cochlear nerve of the gerbil. | one-tone rate suppression has been reported several times for auditory nerve fibers of mammalian and non-mammalian vertebrates. because its properties are very similar to those of two-tone rate suppression, the possibility exists that one-tone rate suppression is the result of an interaction within the inner ear of the suppressing tonal stimulus and some ongoing extraneous acoustic stimulus. for this reason, reports of one-tone rate suppression often elicit suspicions that the investigators were ... | 1992 | 1464563 |
| metabolites of alveolar echinococcus as determined by [31p]- and [1h]-nuclear magnetic resonance spectroscopy. | [31p]-nuclear magnetic resonance (nmr) in vivo spectra of echinococcus multilocularis cysts growing subcutaneously in meriones unguiculatus showed prominent signals due to phosphomonoesters (pme), phosphodiesters (pde), inorganic phosphate (pi) and the alpha, beta and gamma phosphate groups of adenosine triphosphate (atp). the internal ph of the parasite cysts was 6.7-6.8. the 31p spectra of extracts of these subcutaneous cysts showed peaks identified as glucose-6-phosphate (glu-6-p), glycerol-3 ... | 1992 | 1480603 |
| ultrastructural localization of ca(++)-atpases in meissner's corpuscle of the mongolian gerbil. | the cytochemical localization of ca(++)-atpases in meissner's corpuscles of the palatine mucosa of the mongolian gerbil was studied. wachstein-meisel's medium modified by salama et al. (1987) was used for the demonstration of low-affinity ca(++)-atpase or ca++/mg(++)-atpase, whereas the medium devised by körtje et al. (1990) was used for the demonstration of high-affinity ca(++)-atpase. orthovanadate-containing medium, ca(++)- or/and mg(++)-free medium, atp-free medium and preheated sections wer ... | 1992 | 1482602 |
| influence of short-term ischemia on the ultrastructure of hippocampal gyrus in mongolian gerbil. iii. synapses in late stage of the pathological process. | electron microscope analysis of the ca1 ammon's horn sector was performed in mongolian gerbils three days after an incident of short-term ischemia of the forebrain. ca1 pyramidal neurons showed advanced disintegration. some gaba-ergic interneurons revealed ultrastructural alteration of variable degree. the latter finding contradicts the generally helt view on the relative resistance of ca1 sector interneurons to the ischemic injury. synapses localized in all cortical layers of the ca1 sector exh ... | 1992 | 1484606 |
| brain vasculature and mitochondrial responses to ischemia in gerbils. i. basic anatomical patterns and biochemical correlates. | a unique blood supply to the brain, the 'circle of willis' (cow), exists in all mammals except for the mongolian gerbil (meriones unguiculatus). this system is capable of compensating for a decrease in blood supply in one of the four arteries, which may occur during pathological conditions. the posterior connection between the basilar artery and the carotid artery system have been found to be missing in most gerbils. furthermore, in some of the animals, the anterior communication was not complet ... | 1992 | 1486485 |
| brain vasculature and mitochondrial responses to ischemia in gerbils. ii. strain differences and statistical evaluation. | the correlation between the anatomy of brain vasculature and the metabolic responses to ischemia was studied in two strains of the mongolian gerbil as compared to the albino rat. gerbils belonging to the meriones unguiculatus obtained from tumblebrook farms and from the ny institute for basic research were compared to two lines of the meriones tristrami obtained from two different breeders in israel. in all groups of gerbils and in the albino rats, a significant correlation was found between the ... | 1992 | 1486486 |
| preliminary development of a live drug-controlled vaccine against bovine babesiosis using the mongolian gerbil, meriones unguiculatus. | this study investigated the practicality and potential of the gerbil, meriones unguiculatus, as a source of live babesia divergens vaccine and also as a model for the use of the vaccine in cattle. a series of experiments with gerbils concerning vaccine infectivity, immunogenicity and safety were carried out. it was concluded that the use of rpmi medium/40% foetal calf serum as a diluent improved vaccine infectivity, but that the parasitaemia of the blood obtained from donor gerbils had little or ... | 1992 | 1496778 |
| neuroprotective actions of riluzole in rodent models of global and focal cerebral ischaemia. | riluzole (2 amino 6-trifluoromethoxybenzothiazole), when administered at 4 and 8 mg/kg i.p., 0.5, 4.5, 24 and 28 h after the initiation of ischaemia, significantly reduced the prevalence of slow wave, and increased the proportion of higher frequency activity seen in the quantified electrocorticogram (ecog), during the weeks that followed a 6 min bilateral occlusion of the common carotid arteries in the mongolian gerbil. in focal ischaemia, provoked in fischer rats following the occlusion of the ... | 1992 | 1501783 |
| cones in the retina of the mongolian gerbil, meriones unguiculatus: an immunocytochemical and electrophysiological study. | immunocytochemistry revealed in the retina of the mongolian gerbil three immunologically distinct photoreceptor cell types. rods comprising about 87% of the total receptor population were selectively recognized by an antirhodopsin serum (ao). the most abundant cone type (11-13% of photoreceptors) was labeled by the monoclonal antibody cos-1, specific in mammals to the middle-to-long-wave sensitive cone visual pigments. a minor cone population (2.5-5% of the cones) reacted with the monoclonal ant ... | 1992 | 1502806 |
| histological observation on the female prostate in mongolian gerbils (meriones unguiculatus). | in mongolian gerbils, prostatic buds were found in female fetuses at the 23rd day of gestation. in the mothers the well-developed prostate gland consisting of a paired lobes was situated on either side of the neck of the bladder. | 1992 | 1505631 |
| free radical damage to protein and dna: mechanisms involved and relevant observations on brain undergoing oxidative stress. | iron mediates damage to proteins and dna. the mechanisms of damage not only involve iron but also oxygen free radical intermediates. oxidative damage to dna causes not only strand breaks, but also formation of specific base adducts, such as 8-hydroxy-2'-deoxyguanosine. oxidative damage also inactivates certain enzymes such as glutamine synthetase. novel methods of assessing oxidative damage to tissue, including quantitation of salicylate hydroxylation as an index of hydroxyl free radical flux as ... | 1992 | 1510377 |
| ketanserin reduces neuronal calcium accumulation and cell death in the hippocampus of the mongolian gerbil after transient forebrain ischemia. | excessive neuronal activity combined with an increased release of neurotransmitters is supposed to contribute to the delayed neuronal degeneration in animal models of transient cerebral ischemia. since evidence is accumulating that serotonin (5-ht) exerts an excitatory effect on neurons via 5-ht2 receptors we tested the hypothesis that 5-ht2 receptor antagonists could protect neurons in the gerbil after transient bilateral carotid occlusion. in a first series of experiments, the 5-ht2 receptor a ... | 1992 | 1511266 |
| sound-power collection by the auditory periphery of the mongolian gerbil meriones unguiculatus. i: middle-ear input impedance. | this is the first paper of a series dealing with sound-power collection by the auditory periphery of the gerbil. the purpose of the series is to quantify the physiological action of the gerbil's relatively large tympanic membrane and middle-ear air cavities. to this end the middle-ear input impedance zt was measured at frequencies between 10 hz and 18 khz before and after manipulations of the middle-ear cavity. the frequency dependence of zt is consistent with that of the middle-ear transfer fun ... | 1992 | 1512321 |
| brugia malayi: ivermectin inhibits the exsheathment of microfilariae. | brugia malayi-infected microfilaremic jirds (meriones unguiculatus) were treated with ivermectin at a single dose of 200 micrograms/kg of body weight injected subcutaneously. susceptible aedes aegypti mosquitoes were fed on treated jirds 24 hours later. mosquitoes fed on untreated jirds served as controls. infected mosquitoes were dissected at 1, 3, 24, 48, 72, and 96 hr after the blood meal, and differential counts of sheathed microfilariae, exsheathed microfilariae, and cast sheaths were perfo ... | 1992 | 1539753 |
| changes in regional polyamine profiles in rat brains after transient cerebral ischemia (single versus repetitive ischemia): evidence for release of polyamines from injured neurons. | reversible cerebral ischemia (of 5 min, 15 min, or 3-times 5 min) was produced in 14 mongolian gerbils by occluding both common carotid arteries. after 72 h of recirculation, brains were frozen and processed for measuring regional levels of the polyamines putrescine, spermidine and spermine using hplc and fluorescent detector. ischemia induced a marked increase in putrescine levels throughout the brain, most pronounced after 3-times 5 min ischemia (p less than or equal to 0.05 - p less than or e ... | 1992 | 1542427 |
| [effect of thermochemotherapy on alveolar hydatid disease of the liver]. | the specific aim of this study is to predict the possibility of local hyperthermia as a therapeutic modality for echinococcus multilocularis of the liver. we used meriones unguiculatus, into which larval e. multiocularis, alaska strain, was innoculated. in the experiments of hyperthermia by low output laser for either innoculated liver lesions or the normal liver tissues, the protoscoleces and the germinal layers are destroyed at 41 degrees c for 15 minutes, and normal hepatocytes irreversibly d ... | 1992 | 1552887 |
| in vivo assays for drug resistance in babesia divergens using the mongolian gerbil, meriones unguiculatus. | two in vivo drug resistance assays were developed using gerbils. cross resistance, involving related babesicides as well as the chemically unrelated antibiotic, oxytetracycline, was demonstrated, but the suggestion that imidocarb may select for pathogenic strains of parasites was not supported. limited tests of field strains did not detect resistance. it is suggested that an in vitro assay would be more appropriate for surveys through in vivo assays would be essential for confirmatory studies. | 1992 | 1553433 |
| metabolism of [3-14c]coumarin to polar and covalently bound products by hepatic microsomes from the rat, syrian hamster, gerbil and humans. | the metabolism of 0.19 and 2.0 mm-[3-14c]coumarin to polar products and covalently bound metabolites has been studied with hepatic microsomes from the rat, syrian hamster, mongolian gerbil and humans. [3-14c]coumarin was metabolized by liver microsomes from all species to a number of polar products and to metabolite(s) that became covalently bound to microsomal proteins. the polar products included 3-, 5- and 7-hydroxycoumarins, o-hydroxyphenylacetaldehyde and o-hydroxyphenylacetic acid. coumari ... | 1992 | 1555792 |
| the envelope following response: scalp potentials elicited in the mongolian gerbil using sinusoidally am acoustic signals. | scalp potentials which follow the low frequency envelope of a sinusoidally amplitude modulated stimulus waveform were evoked and recorded in anesthetized gerbils. this envelope following response (efr) is presumably due to the synchronized discharge of populations of neurons in the auditory pathway. the magnitude of the efr increased and the latency decreased in a near monotonic fashion with increased stimulus intensity and modulation depth. the modulation rate transfer function (mrtf) was deter ... | 1992 | 1559908 |
| animal species differences in erythrocyte aggregability. | species differences in erythrocyte aggregability were investigated employing our whole blood erythrocyte aggregometer. blood was sampled from seven species, including humans and anesthetized (30 mg/kg pentobarbital) animals. the erythrocyte aggregation rates were the following (in s-1): cats, 0.213 +/- 0.027 (means +/- sd); dogs, 0.164 +/- 0.027; men, 0.112 +/- 0.025; rats, 0.111 +/- 0.005; domestic rabbits, 0.049 +/- 0.021; and mongolian gerbils, 0.034 +/- 0.015. domestic fowls did not exhibit ... | 1992 | 1566883 |
| intestinal capillariasis. | intestinal capillariasis caused by capillaria philippinensis appeared first in the philippines and subsequently in thailand, japan, iran, egypt, and taiwan, but most infections occur in the philippines and thailand. as established experimentally, the life cycle involves freshwater fish as intermediate hosts and fish-eating birds as definitive hosts. embryonated eggs from feces fed to fish hatch and grow as larvae in the fish intestines. infective larvae fed to monkeys, mongolian gerbils, and fis ... | 1992 | 1576584 |
| [organ weights of the mongolian gerbils (meriones unguiculatus)]. | | 1992 | 1577921 |
| on the infectivity of early third-stage brugia larvae isolated from the abdomen of aedes aegypti. | third-stage larvae (l3) of wuchereria bancrofti, brugia malayi and b. pahangi are known to be recovered not only from the head and thorax but also from the abdomen of dissected vector mosquitoes. for epidemiological reasons, was of interest to determine whether l3 larvae from the abdomen of the vector would be infectious for the final host. early abdominal l3 larvae of b. pahangi isolated as early as on day 7 post-infection (p.i.) from aedes aegypti were injected s.c. into five male meriones ung ... | 1992 | 1584752 |
| behavioral response of altricial and precocial rodent fetuses to acute umbilical cord compression. | norway rat fetuses (rattus norvegicus) exhibit a stereotypic behavioral response when the umbilical cord is experimentally compressed with a vascular clamp. in this study, the development of the fetal behavioral response to cord compression was compared in altricial and precocial rodents, which differ markedly in neural and motor maturity at the time of birth. both altricial and precocial species showed some form of behavioral response to umbilical cord compression. fetuses of two altricial spec ... | 1992 | 1586357 |
| isolation of two giardia lamblia (wb strain) clones with distinct surface protein and antigenic profiles and differing infectivity and virulence. | to determine the relationship between antigenic profiles and pathogenicity among giardia lamblia clones (wb strain), trophozoites were cloned by the technique of limiting dilution. the phenotype of each clone was determined by an indirect immunofluorescence test using a polyclonal rabbit anti-g. lamblia trophozoite serum made against the parent strain. two clones were chosen for further studies: a highly fluorescent clone, f+, in which more than 95% of the trophozoites fluoresced, and a low-fluo ... | 1992 | 1587594 |
| coat color genes and cage temperature effects on care of the body surface (cobs) behavior of meriones unguiculatus. | male and female mongolian gerbils (meriones unguiculatus) carrying three coat color alleles, agouti, sandy, and black, were tested for 15 min under three cage temperature conditions, warm (35-40 degrees c), neutral (20 degrees c), and cold (0-5 degrees c). a frequency count of scratching, face and body wash, belly/side rubs, and shaking was taken of these animals' activities during the test sessions. sex differences were not evident but coat color and age temperature affected the belly/side rubs ... | 1992 | 1590729 |
| growth and development of haemonchus contortus in jirds, meriones unguiculatus. | growth and development of haemonchus contortus were examined in jirds and were compared to these processes in lambs. number, sex, size, and stage of development were determined for worms recovered at necropsy at various times postinoculation (pi) from immunosuppressed jirds inoculated with approximately 1,000 exsheathed infective larvae (l3) of h. contortus. in addition, gastric tissue samples from jirds were examined histologically. parallel studies were done in lambs inoculated with approximat ... | 1992 | 1597794 |
| comparison of montana and alaska isolates of echinococcus multilocularis in gerbils with observations on the cyst growth, hook characteristics, and host response. | to assess its biological distinctness, an isolate of echinococcus multilocularis from montana was compared with an isolate from alaska in gerbils (meriones unguiculatus) by means of intraperitoneal inoculations with protoscoleces. the cysts formed by the montana isolate were entire, hyaline, and translucent, whereas those produced by the alaska isolate were granular, yellowish, and opaque. vesicles of the montana isolate were larger, produced protoscoleces more slowly but in greater numbers, and ... | 1992 | 1597801 |
| postnatal development of the cervical epithelium in the mongolian gerbil. | this study analyzes the postnatal development of the mongolian gerbil's cervical epithelium, in relation to its future functions. in the newborn gerbil the outline of the cervical canal is smooth, showing hardly any signs of folding. the epithelium consists of 1 to 3 layers. the cervical cells have rounded apices of regular outline and contain a large amount of glycogen. the first secretory products of specific mucus type appear about day 23 postnatally (p.n.). initially two types of vesicles ca ... | 1992 | 1605373 |
| n omega-nitro-l-arginine-methyl ester inhibits electrocortical recovery subsequent to transient global brain ischemia in mongolian gerbil. | electrocorticographic (ecog) activity remains isoelectric for about 15 min after transient (10 min) bilateral carotid arteries occlusion in mongolian gerbils. in this model of global forebrain ischemia n omega-nitro-l-arginine methyl ester (l-name), a nitric oxide (no) synthase inhibitor, significantly delays the recovery of ecog amplitude. thus, the present experiments suggest that no is involved in the cerebrovascular physiological response to brain ischemia. | 1992 | 1607127 |
| intrauterine positions and testosterone levels of adult male gerbils are correlated. | those male mongolian gerbils (meriones unguiculatus) that developed in intrauterine positions between two male fetuses had significantly higher levels of serum testosterone, as adults, than did those adult male gerbils that developed in intrauterine positions between two female fetuses. the endogenous testosterone levels of adult male gerbils were significantly positively correlated with both the sizes of their ventral scent glands and their frequencies of scent marking. we found no evidence of ... | 1992 | 1615057 |
| frequency and intensity discrimination in mongolian gerbils, african monkeys and humans. | frequency (delta f) and intensity (delta i) difference limens were directly compared in mongolian gerbils (meriones unguiculatus), old world african monkeys (cercopithecus mitis, cercocebus albigena), and humans. methods employed a repeating background ax discrimination procedure, and positive (food) reinforcement for animals. for delta i, there were small quantitative differences between the species. at 1 khz, 70 db spl, dls averaged 2.82 db for gerbils, 2.29 db for monkeys, and 0.75 db for hum ... | 1992 | 1618711 |
| demonstration of dopamine-immunoreactive cells in the gastrointestinal tract of gerbils (meriones unguiculatus). | we investigated dopamine immunoreactivity in the small intestine of gerbils (meriones unguiculatus), using a sensitive and selective antibody against glutaraldehyde-conjugated dopamine. dopamine-immunoreactive cells were found within the mucosal epithelium along the entire extent of the small intestine. labeled cells were regularly distributed in the upper half of the intestinal villi, basally attached to the basement membrane and always reaching as far as the epithelial surface. dopamine-contai ... | 1992 | 1619282 |
| impaired acquisition of the morris water maze following global ischemic damage in the gerbil. | five minutes of global ischemia in the mongolian gerbil impaired acquisition of a morris water maze task when testing began 72 h after surgery. in spite of extensive damage to ca1 pyramidal cells, ischemic animals eventually learned to locate a submerged platform and performed normally on a subsequent retention test. animals that were allowed a more protracted recovery period (21 days) acquired the task as readily as control gerbils. these results suggest that undamaged structures within and ext ... | 1992 | 1623175 |
| recombinant human superoxide dismutase can attenuate ischemic neuronal damage in gerbils. | the effects of recombinant human superoxide dismutase (r-hsod) on ischemic neuronal injury were examined. cerebral ischemia was produced in mongolian gerbils by occluding bilateral common carotid arteries for 5 min. preischemic treatment with r-hsod clearly reduced hippocampal neuronal damages while postischemic treatment did not. this result suggests that oxygen free radicals play an important role in selective vulnerability to ischemia and r-hsod has a potential clinical usefulness against cer ... | 1992 | 1625516 |
| changes in the surface composition after transmission of acanthocheilonema viteae third stage larvae into the jird. | this study describes the dynamics and the biochemical nature of changes in the surface of the filarial nematode acanthocheilonema viteae after its transmission into the vertebrate host. vector-derived third-stage larvae (ml3) were inoculated into naive meriones unguiculatus and recovered from the tissues at different times post-infection until their moult to fourth-stage larvae (l4). surface-specific labelling with fluoresceinated lectins revealed that the larvae are covered by a carbohydrate en ... | 1992 | 1625708 |
| pathophysiology of small intestinal malabsorption in gerbils infected with giardia lamblia. | mongolian gerbils were infected with a human pathogenic giardia lamblia strain and compared with sham-treated control animals 6 days after inoculation. infection resulted in crypt hyperplasia associated with an increased enterocyte migration rate. villus height was decreased in the duodenum, unchanged in the jejunum, and increased in the ileum of infected animals. epithelial microvilli were markedly shortened, and brush border surface area decreased in the jejunum and ileum of infected animals. ... | 1992 | 1634068 |
| development and application of protein g antibody assay for the detection of antibody to hantavirus. | a new serodiagnostic method designated protein-g antibody assay (pga) was developed for detection of hantavirus infection in various species of animals. the assay procedure includes reacting the sera with hantavirus-infected cells on glass slides, followed by incubation of biotinylated protein g and amplification with the avidin-biotinylated peroxidase complex. specific antibody in rabbit, rat, mouse and mongolian gerbil serum was detected by this method. the pga titres were similar to those of ... | 1992 | 1634601 |
| refinement of dendritic arbors along the tonotopic axis of the gerbil lateral superior olive. | we have investigated the development of dendritic arbors in a central auditory nucleus in the mongolian gerbil, the lateral superior olive (lso). the morphology of these arbors has been shown to vary with tonotopic position in adults, with high frequency neurons having a more restricted field. in the present study, qualitative observations were made on horseradish peroxidase-filled neurons from animals 1-11 days postnatal, and quantitative results were obtained from golgi-impregnated material fr ... | 1992 | 1638742 |
| quantitative characterization of hormone receptors by a nonlinear regression approach. | this paper describes a mathematical model for the quantification of receptors based only upon the total bound values as a function of the total ligand concentration. in contrast to methods relying on linearization transformations, this nonlinear model requires more sophisticated computation, however, avoids loss of material for determination of nonspecific binding in competed tubes. monte-carlo simulation indicated high stability of this model against random experimental error. the androgen rece ... | 1991 | 1654996 |
| neuroprotective actions of gr89696, a highly potent and selective kappa-opioid receptor agonist. | 1. the effect of a novel, highly potent and selective kappa-opioid receptor agonist, gr89696, has been evaluated in two animal models of cerebral ischaemia: transient bilateral carotid artery occlusion in the mongolian gerbil and permanent, unilateral middle cerebral artery occlusion in the mouse. 2. in the mongolian gerbil model, administration of gr89696 (3 to 30 micrograms kg-1, s.c.), immediately before and at 4 h after insult, produced a dose-dependent reduction in the hippocampal ca1 neuro ... | 1991 | 1657267 |
| reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound n-tert-butyl-alpha-phenylnitrone. | oxygen free radicals and oxidative events have been implicated as playing a role in bringing about the changes in cellular function that occur during aging. brain readily undergoes oxidative damage, so it is important to determine if aging-induced changes in brain may be associated with oxidative events. previously we demonstrated that brain damage caused by an ischemia/reperfusion insult involved oxidative events. in addition, pretreatment with the spin-trapping compound n-tert-butyl-alpha-phen ... | 1991 | 1673789 |
| protection against oxidative damage to cns by alpha-phenyl-tert-butyl nitrone (pbn) and other spin-trapping agents: a novel series of nonlipid free radical scavengers. | brain is extremely susceptible to oxidative damage. utilizing a series of novel approaches, we have demonstrated that oxidative damage occurs during an ischemia/reperfusion insult (iri) to brain. thus, we have demonstrated that an iri to mongolian gerbil brain results in: (1) an enhanced rate of salicylate hydroxylation, implicating an increased flux of hydroxyl free radicals; (2) an enhanced flux of free radicals as determined by spin-trapping; (3) an enhanced level of endogenous protein oxidat ... | 1991 | 1679344 |
| susceptibility of laboratory and wild rodents to rattus or apodemus-type hantaviruses. | adult wistar rats (rattus norvegicus), apodemus agrarius, meriones unguiculatus, clethrionomys rufocanus, and apodemus argenteus were inoculated with rattus-type (sr-11, ki-262, and tb-314) or apodemus-type (hantaan 76-118) hantaviruses. production of serum antibody to the inoculated virus (iaha titres of 1:32 to 1:4 096) was obsersved in all rodent species 10 weeks after virus inoculation. rattus-type virus was detected in some organs of all the rodent species employed except of apodemus agrari ... | 1991 | 1683116 |
| the distribution of water in the intracellular and extracellular compartments and the lipid and protein composition of the mongolian gerbil (meriones unguiculatus) during water deprivation. | 1. the plasma, interstitial, extracellular and intracellular volumes fell to similar extents after 5 days of water deprivation in male and female gerbils. there was no selective plasma volume conservation. 2. the female gerbils lost more weight on water deprivation yet the total body water loss was very similar to that in the male animals. while there was a small fall in the protein content of the male animals the extra loss of weight in the females appeared to be due to the considerable catabol ... | 1991 | 1685383 |
| application of confocal laser scanning microscopy to the deep pineal gland and other neural tissues. | the study of the deep pineal gland of the mongolian gerbil and other neuronal tissue from the rat by means of confocal laser scanning microscopy (clsm) is described. opical serial sectioning was performed on thick (100-200 microns) sections of the deep pineal gland of the mongolian gerbil stained immunohistochemically using antisera to s-antigen and tyrosine hydroxylase (th). both dual-stained and single-stained material was examined using the fluorochromes fluorescein isothiocyanate (fitc) and ... | 1991 | 1686536 |
| dendritic morphology of central auditory neurons correlates with their tonotopic position. | we have investigated the morphology of dendritic arbors in a central auditory nucleus, the lateral superior olive, of the mongolian gerbil. morphometric observations were obtained directly from golgi-impregnated material by using a microcomputer-based three-dimensional data acquisition system. in particular, measurements were made to determine the dendritic arborization across each of three axes: the tonotopic axis, the rostrocaudal axis, and the isofrequency axis (i.e., perpendicular to the ton ... | 1990 | 1692853 |
| immunohistochemical localization of prostaglandin f2 alpha in reperfused gerbil brain. | immunohistochemical localization of prostaglandin (pg) f2 alpha synthesized during recirculation following experimental forebrain ischemia was studied in mongolian gerbils. the bilateral carotid arteries were clamped for 5 minutes, and the brains were frozen in situ after 5 minutes of recirculation. sham-operated gerbils not subjected to arterial occlusion served as controls. cryostat sections containing dorsal hippocampus 10 microns in thickness were incubated in rabbit anti-pgf2 alpha serum an ... | 1990 | 1696690 |
| lethal effects of ccl4 and its metabolism by mongolian gerbils pretreated with chlordecone, phenobarbital, or mirex. | gerbils are much more sensitive to the hepatotoxic and lethal effects of ccl4 than rats as indicated by 48-hr ld50 values (0.08 vs 2.8 ml/kg). on the other hand, gerbils are refractory to chlordecone (cd) potentiation of ccl4 toxicity. to investigate the possible mechanism underlying the high sensitivity of gerbils to ccl4 lethality, the metabolism of ccl4 was studied in gerbils pretreated with dietary cd, phenobarbital (pb), or mirex (m) at 10, 225, and 10 ppm, respectively. the hepatic content ... | 1990 | 1696756 |
| the glial architecture of the median eminence of the mongolian gerbil (meriones unguiculatus); a study of glial fibrillary acidic protein (gfap) immunoreactivity in semithin sections. | the glial architecture of the median eminence (me) of the mongolian gerbil (meriones unguiculatus) was studied immunohistochemically. for this purpose, semithin sections of the proximal me were processed according to the pap technique using antibodies directed against glial fibrillary acidic protein (gfap). various glial cells were stained. their distribution, the arrangement and morphology of their processes, and the spatial relations with adjacent tissue components could be examined in detail. ... | 1990 | 1699378 |
| projections from the lateral geniculate nucleus to the hypothalamus of the mongolian gerbil (meriones unguiculatus): an anterograde and retrograde tracing study. | the lateral geniculate nucleus of the thalamus sends efferents to the hypothalamic suprachiasmatic nucleus, which is involved in generation and entrainment of several circadian rhythms. it seems reasonable to believe that the lateral geniculate conveys visual information about the length of the photoperiod to the circadian oscillator. in order to study in more detail the topographical relationship between the lateral geniculate and the suprachiasmatic nucleus, anterograde tracing with phaseolus ... | 1990 | 1700802 |
| [effects of radiation on capillary endothelial cells derived from mongolian gerbil brain]. | confluent monolayers of capillary endothelial cells derived from mongolian gerbil brain were irradiated with a single exposure of x-rays, and their radiosensitivity and sequential changes in morphology, staining intensity for factor viii-related antigen (f viii rag), and capacity to produce prostacyclin (pgi2) were examined. the radiobiologic parameters that characterized the dose-response survival curve for these cells were found to be n = 1.9, dq = 140 rad, and d0 = 190 rad. morphologically, n ... | 1990 | 1700917 |
| purification and characterization of giardia lamblia antigens in the feces of mongolian gerbils. | in a recent study, we identified giardia lamblia 65- and 70-kda antigens in the feces of infected mongolian gerbils. the 65-kda antigen was from a strain isolated from a human with symptoms of giardiasis, and the 70-kda antigen was from a strain isolated from a human with no symptoms of giardiasis. in this study, we used preparative electrophoresis and electroelution techniques to purify these antigens to a degree which showed a single discrete protein band on silver-stained polyacrylamide gels. ... | 1991 | 1704383 |