| hypotensive and antiarrhythmic effects of a new alkaloid, the 13-hydroxylupanine-2-pyrrolcarbonic acid ester, from the madagascan plant cadia ellisiana. | the alkaloid 13-hydroxylupanine-2-pyrrolcarbonic acid ester (hoe 933) from the madagascan plant cadia ellisiana has an hypotensive and antiarrhythmic effect. the hypotensive effect in dogs, monkeys, and rats anaesthetized with barbiturates reaches its maximum with 0.2 mg/kg i.v. however, the hypotensive effect is much weaker in conscious animals. the enteral absorption in the dog is good; an intraduodenal dose of only 0.5 mg/kg lowered the blood pressure. in the isolated rabbit heart whose accel ... | 1976 | 11808 |
| cardiovascular effects of dopamine after central administration into conscious cats. | dopamine (30 and 45 mug) administered intracerebroventricular (i.c.v.) to a group of 10 conscious normotensive cats caused dose-related increases in blood pressure and heart rate. in 4 of these animals the initial cardiovascular stimulant effects of i.c.v. dopamine were followed by hypotension and bradycardia. 2 alpha-methyldopamine (30 and 45 mug i.c.v.) produced qualitatively similar responses to dopamine except that the cardiovascular stimulant effects were smaller and the secondary depressan ... | 1976 | 11861 |
| neurotransmitter-related enzymes and indices of hypoxia in senile dementia and other abiotrophies. | fifty-six brains from middle-aged and elderly normal as well as demented subjects and patients with provisional clinical diagnosis of other neurological and psychiatric diseases were assessed histologically. on this basis the specimens were classified into 14 diagnostic groups. a survey of potential indices of specific neurons has been carried out on these brains in which neurotransmitter-related enzymes, gamma-gtp (a potential index of capillaries) and specific proteins have been determined in ... | 1976 | 11871 |
| comparative study of the beta-adrenergic blocking properties of aroxyalkanolamine derivatives. | | 1976 | 12002 |
| the effects of methylation on the pharmacological actions of (+)-tubocurarine proceedings. | | 1976 | 12361 |
| respiratory acid-base changes and myocardial contractility: interaction between calcium and hydrogen ions. | | 1976 | 12373 |
| effects of benzodiazepines and pentobarbital on the evoked potentials in the cat brain. | the sites of action of benzodiazepines, diazepam and id-540 7-chloro-5-(o-fluorophenyl)-1-methyl-1,3-dihydro-2h-1,4-benzodiazepin-2-one) on the central nervous system were examined and compared with those of pentobarbital using evoked potentials recorded on the limbic system and hypothalamus in the cat brain. benzodiazepines affected the various neuronal connections of the intra-limbic, limbic-hypothalamic and midbrain-limbic systems; especially the amygdala (amyg)-, ventromedial hypothalamus (v ... | 1976 | 12387 |
| antagonizing effects of beta-adrenergic blockers on lucus coeruleus-induced inhibition of trigeminal nucleus neurons. | effects of alpha- and beta-adrenergic blocking agents applied into the lateral ventricle were studied on the relay neuron in the rostral part of spinal trigeminal nucleus (stn) of cats. conditioning stimulation of the locus coeruleus (lc) and sensory cortex (sc) inhibited the orthodromic spike generation in stn relay neuron without affecting the antidromic spike, as already reported, and re-confirmed herein. the lc-induced inhibition of orthodromic spike was significantly reduced by intraventric ... | 1976 | 12391 |
| inhibition by locally applied alpha-adrenoreceptor blocking drugs of the depressor response to stimulation of the anterior hypothalamus. | cats were anaesthetized with pentobarbital sodium and the anterior hypothalamus was superfused with artificial cerebrospinal fluid through a push-pull cannula. electrical stimulation of the superfused area with the tip of the cannula elicited a fall of the arterial blood pressure which was dependent on frequency and voltage. maximal depressor response was obtained at 60 hz with 2-4v; further increase of the voltage often led to a rise of the arterial blood pressure. superfusion of the anterior h ... | 1976 | 12481 |
| the action of a toxin from the sea anemone anemonia sulcata upon mammalian heart muscles. | the cardiac activity of toxin ii, a basic polypeptide (m.w.: 4770) from the sea anemone anemonia sulcata, was investigated in isolated electrically driven guinea-pig and rat auricles, langendorff heart preparations of guinea-pigs and cat heart-lung preparations. low concentrations of toxin ii (2-100 nm) evoked a dose-dependent positive inotropic effect in the three different heart muscle preparations investigated. higher concentrations of toxin ii produced toxic symptoms like contracture and arr ... | 1976 | 12483 |
| action of enpiprazole on emotional behavior induced by hypothalamic stimulation in rats and cats. | action of enpiprazole on emotional behavior elicited by hypothalamic stimulation in rats and cats was investigated and comparisons were made with effects of diazepam. two behavioral patterns were elicited by stimulation of the postero-medial part of the hypothalamus in rats: a food-carrying response beginning with exploratory movement and an analogue of fear. enpiprazole frequently changed the food-carrying response into food-taking response and occasionally analogues of fear into food-carrying ... | 1976 | 12526 |
| the timor filaria on flores and experimental transmission of the parasite. | | 1976 | 12599 |
| ph environmental of red cells in the spleen. | intrasplenic ph in vivo was deduced from measurements on blood drained from cat spleen during contraction with the inflow occluded. the ph of blood in the red pulp is normally 7.20, but stasis or reduced flow through the pulp causes ph to fall toward 6.8. the splenic pulp contains blood of high hematocrit. to evaluate the role of buffering by the red cells themselves, intrasplenic p/ in red cell-free spleens was, therefore, estimated atering and leaving the spleen during red cell washout. at inf ... | 1976 | 12663 |
| effect of an analeptic mixture on the bioelectrical activity of the cerebral hemispheres. | | 1976 | 12671 |
| profile of pharmacological actions of nab 365 (clenbuterol), a novel broncholytic agent with selective activity on adrenergic beta2-receptors (author's transl). | effects of 4-amino-alpha-(tert.-butylamino)methyl-3,5-dichlorobenzyl alcohol hydrochloride (clenbuterol, nab 365) on the adrenergic beta-receptors were investigated and compared with those of isoproterenol and salbutamol. the beta2-mimetic activity of clenbuterol on the smooth muscle of bronchi, uterus and vessels after i.v. injection corresponds to that of salbutamol in all laboratory animals. when given subcutaneously or as an aerosol clenbuterol is even somewhat more effective than isoprotere ... | 1976 | 12768 |
| relation between hypoxic pulmonary vasoconstriction, its humoral mediators and alpha-beta adrenergic receptors. | | 1977 | 12924 |
| iontophoretic studies of histamine and histamine antagonists in the feline vestibular nuclei. | the activity of single neurons in the vestibular neuronal complex of midcollicular decerebrate, decerebellectomized cats were recorded and their responsiveness to iontophoretically applied histamine and other agents determined. the majority of the cells tested were inhibited by iontophoresis of histamine while 24% were excited by this agent. neurons exhibiting inhibitory responses were widely distributed throughout the four vestibular nuclei and adjacent reticular formation whereas excitatory re ... | 1977 | 12984 |
| effects of a benzodiazepine derivative, ms4101, on emotional behaviour of untamed cats. | effects of ms4101 on emotional behaviour in untamed cats were studied and compared with those of diazepam. offensive behaviour, i.e., whine response to a rod presented in front of the snout and blowing air on back hair was markedly observed, and whine, attacking and biting responses to tapping with a rod on the back in these cats were marked. defensive behaviour, i.e., hissing, crouching body, ear flattening to blowing air on back hair, a rod presented and tapping was markedly observed. from 30 ... | 1976 | 13029 |
| homosynaptic depression and transmitter turnover in spinal monosynaptic pathway. | 1. the transmission in the spinal monosynaptic pathway was studied during repetitive stimulation of a motor nerve by 10 stimuli at 2, 5, or 10 hz in spinal cats. initially, the amplitudes of the monosynaptic responses rapidly declined, reaching a plateau after a few stimuli. the level of the plateau was inversely related to the frequency of stimulation. 2. this depression of monosynaptic response was seen only when the same pathway was stimulated; the response elicited from the lateral gastrocne ... | 1977 | 13160 |
| marked difference in the susceptibility of several species to guanethidine-induced chemical sympathectomy. | | 1977 | 13257 |
| effects of two benzodiazepines, phenobarbitone, and baclofen on synaptic transmission in the cat cuneate nucleus. | the effects of diazepam, flunitrazepam, phenobarbitone and baclofen on excitatory as well as on pre- and postsynaptic inhibitory processes in the cuneate nucleus were studied in decerebrate cats. afferent presynaptic inhibition in the cuneate nucleus, evoked by volleys in the median nerve, and assessed by the size of the positive cuneate surface potential (p wave), the dorsal column reflex (dcr), and the increased excitability of primary afferent terminals of the ulnar nerve, was markedly enhanc ... | 1976 | 13311 |
| effects of cimetidine on adenylate cyclase activity of guinea pig gastric mucosa stimulated by histamine, sodium fluoride and 5'-guanylylimidodiphosphate. | cimetidine, a recently developed histamine h2-receptor blocking agent has been shown to be a potent inhibitor of histamine-stimulated gastric acid secretion in rat, cat, dog and man. to study the mode of action of cimetidine the modification of stimulatory effects of histamine, sodium flouride and 5'-guanylylimidodiphosphate by cimetidine on the adenylate cyclase activity of guinea pig gastric mucosa was studied. the effect of cimetidine was also compared to that of metiamide, an older histamine ... | 1976 | 13313 |
| microiontophoresis of acetylcholine, histamine and their antagonists on neurones in the medial and lateral vestibular nuclei of the cat. | | 1976 | 13324 |
| correlations between hydrophobicity and non-specific pharmacological effects of beta-adrenoceptor blocking agents. | it was the aim of this study to test whether the non-specific pharmacological activities of the beta-adrenergic blocking drugs can be predicted by estimation of the hydrophobicity of the compounds. srong correlations were obtained between the octanol buffer partition coefficients and the ability of the drugs to decrease conduction velocity of the isolated frog heart, to raise the electrically induced ventricular fibrillation threshold in guinea pigs, and to depress ventricular contractility in t ... | 1976 | 13353 |
| effect of duodenal acidification on pentagastrin-stimulated acid secretion in pavlov pouch cats. | | 1976 | 13486 |
| neurohumoral reactions of the resistive and capacitative vessels of the small intestine in cats under the piedmont conditions in the tien shan. v. | | 1976 | 13563 |
| neurohumoral reactions of the resistive and capacitative vessels of the skin-muscle area in cats under the piedmont conditions in the tien shan. (vi). | | 1976 | 13571 |
| purification and properties of two protease inhibitors from rat skin inhibiting papain and other sh-proteases. | two papain inhibitors, i1 and i2, from rat skin extract were purified by affinity chromatography on kscn-modified papain-agarose gel and by gel filtration on sephadex g-100. i1 had a molecular weight of 74 000, a pi of 4.6, and it contained 4% of carbohydrates. i1 inhibited papain, ficin, bromelain, rat skin benzoylarginine-2-naphthylamide hydrolase, and to a minor extent, rat skin cathepsin c and bovine trypsin. bovine chymotrypsin or rat skin cathepsin d were not inhibited and benzoylarginine- ... | 1976 | 13595 |
| characterization of the adrenergic beta-receptor in the urinary bladder of man and cat. | the corpus-fundus of the urinary bladder of man and cat was studied in vitro with respect to type of beta-adrenergic receptors. in both species beta-adrenergic stimulation produced marked relaxation but species differences were apparent. in the cat bladder only beta1-receptors were found. in the human bladder the beta-receptors had neither beta1- nor beta2-characteristics. it is suggested that the beta-adrenergic receptors in the corpus-fundus of the human bladder are of a third type. | 1977 | 13606 |
| cerebral oxygen supply in brain edema and during ventriculo-cisternal perfusion. | | 1976 | 13617 |
| experimental analysis of anti-hypertensive effects of beta-adrenergic blocking agents. | | 1976 | 13671 |
| neurophysiologic justification of the place of neuroleptics in neuroleptanalgesia. | we studied the action of drugs on the cortical and systemic hemodynamic responses to reticular stimulation and somatic nociceptive stimulation. central analgesics, even in high dosage, do not suppress the awakening reaction and the attack of hypertension produced by sciatic stimulation in curarised cats. the addition of a neuroplegic, such as droperidol or ethrane in low dosage, abolishes completely the response to painful stimulation. the action of pure analgesic anesthesia seems to be situated ... | 1976 | 13690 |
| fluorescence histochemical study of the central monoaminergic neuron system on experimental torticollis in the cat (author's transl). | | 1976 | 13752 |
| effects of antihistaminic drugs on feline brain monoamine metabolism. | | 1977 | 13798 |
| differentiation of metabolic adrenoceptors. | 1 cardiovascular and metabolic responses to intravenous infusion of isoprenaline were measured in fasted, anaesthetized cats. 2 isoprenaline (0.2 mug kg-1 min-1 for 15 min) decreased diastolic blood pressure and increased heart rate, blood glucose, blood lactate and plasma free fatty acids. 3 oxprenolol (0.5 mg/kg) antagonized all cardiovascular and metabolic effects of isoprenaline non-selectively. 4 para-oxprenolol (0.25 mg/kg) and practolol (4 mg/kg) antagonized the effects of isoprenaline on ... | 1977 | 13899 |
| mechanism of neurotoxicity of cardiotonic glycosides. | 1 in cats intracerebroventricular administration of 5, 10, 20 mug of peruvoside, a cardiac glycoside obtained from the plant, thevetia neriifolia, and 10 and 20 mug of ouabain, produced marked neurotoxicity. this was dose-related. 2 prior administration reserpine (2 mg/kg i.m., 500 mug i.c.v.) or tetrabenazine (25 mg/kg i.v., 50 mg/kg i.v. and 2 mg/,g i.c.v.) suppressed the neurotoxicity, but lithium carbonate (100 mg/,g i.p., 2 mg 2.c.v.) and haloperidol (200 mug i.c.v.) were ineffective. 3 pri ... | 1977 | 13903 |
| aminotetralins as selective beta-adrenergic agonists. | aminotetralin derivatives m-8 and jod-176, were studied in relation to isoproterenol for beta-adrenergic activity. m-8 and jod-176 were found to be very weak in activating cardiac beta-receptors. these compounds were also found to be considerably more active in uterine and bronchial smooth muscle. because these compounds were also shown to be very inactive in vascular smooth muscle, the possibility that beta-receptors in different smooth muscle types may also differ was suggested. | 1977 | 14012 |
| influence of the vagus nerve on renal excretion of blood coagulating substances in the presence of adrenergic receptor blockades. | | 1976 | 14034 |
| carotid chemoreceptor responses to sympathetic excitation proceedings. | | 1976 | 14254 |
| relaxation of heart muscle by catecholamines and by dibutyryl cyclic adenosine 3',5'-monophosphate. similarity of beta-adrenoceptors mediating contractile and relaxant effects of catecholamines in kitten pipillary muscle. | 1. in isometrically contracting kitten papillary muscles, dibutyryl cyclic amp (dbcamp) enhanced peak tension, increased rates of contraction and relaxation, decreased tension of a phasic but not of a small tonic component of kcl-contractures, and caused aftercontractions. these effects resemble closely those of catecholamines. 2. the effects of dbcamp on kitten papillary muscle were not influenced by (-)-bupranolol, a beta-adrenoceptor antagonist. 3. dbcamp decreased kcl-contractures in strips ... | 1977 | 14305 |
| activation of myocardial beta-adrenoceptors by the nitrogen-free low affinity ligand 3',4'-dihydroxy-alpha-methylpropiophenone (u-0521). | the effect of 3',4'-dihydroxy-alpha-methylpropiophenone (u-0521) on the rate of spontaneously contracting cultured rat heart cells and right atria of rats and kittens was investigated. the action of u-0521 on the cellular content of cyclic amp and on the adenylyl cyclase of heart membrane particels was also studied. 1. u-0521 caused positive chronotropic effects on single cultured heart cells and right atria of the rat. u-0521 was about 10(5) times less potent than (--)-isoprenaline. the maximum ... | 1977 | 14306 |
| changes in electrocortical activity induced by the perfusion of 5-hydroxytryptamine into the nucleus of the solitary tract. | | 1977 | 14313 |
| inhibition of adrenergic beta receptors by n,n'-bis-3-(2'ethoxyphenoxy)-2-hydroxypropyl-ethylenediamine (falirytmin) as compared to propranolol. | | 1976 | 14343 |
| experimental studies on the effect of barbiturates, methaqualone and benzodiazepines in acute isoniazid intoxication. | | 1977 | 14345 |
| the role of brief hypocapnia in the ventilatory response to co2 with hypoxia. | in conscious cats the ventilatory response curve to physiological range of co2 is displaced upward by hypoxia (about 45 torr), but it rises, either parallel with, or convergent on, the normoxic curve. thus, a positive interaction of hypoxia and hypercapnic stimuli is not observed under these circumstances. however, if during the hypoxic exposure, hypocapnia is allowed to develop, the subsequently determined co2 ventilatory response curve will shift to the left, rise steeply, particularly in the ... | 1976 | 14364 |
| importance of mucosal surface area in h+ disposal in the duodenum. | | 1976 | 14406 |
| vagal release of somatostatin into the antral lumen of cats. | | 1977 | 14480 |
| the essential action of propranolol in hypertension. | the unique action of propranolol and other beta blockers in lowering raised arterial pressure is discussed. although the onset of the antihypertensive effect is not immediate, many trials have confirmed the efficacy of these drugs. animal experiments have thrown little light on the mechanism of action of beta blockers in hypertension: this may be because in animals, especially the rat, peripheral beta adrenoceptor vasodilatation is relatively more important than in man. five principal theories h ... | 1976 | 14498 |
| beta-blockers--pharmacological and haemodynamic aspects. | | 1976 | 14621 |
| responsiveness of neurones in the hippocampal region of anaesthetised and unanaesthetised cats to stimulation of sensory pathways. | the responses to sensory stimuli and to shocks to the optic pathways have been studied for 399 units in the hippocampal region of 19 cats. 172 units were recorded from anaesthetised cats and 229 from 7 unanaesthetised cats. in the unanaesthetised animals the proportions of units responding were high (60%) and did not differ significantly between regions for each type of stimulation investigated: visual, auditory and optic chiasma shocks. the proportion of units responsive to chiasmatic stimulati ... | 1977 | 14768 |
| protective action of timolol in acute myocardial ischemia. | timolol, a beta-adrenoceptor blocking agent with little or no cardiodepressant activity, was studied in acute myocardial ischemia in cats. timolol, at a dose of 25 mug/kg, blocked 75 to 80% of the cardiac response to isoproterenol. this dose also significantly reduced heart rate in cats subjected to acute myocardial ischemia by ligation of the left coronary artery. timolol significantly prevented the spread of ischemic damage in the myocardium as assessed by (a) curtailing the increase in plasma ... | 1977 | 14835 |
| physiology and chemistry of cerebrospinal fluid, aqueous humor and endolymph in squalus acanthias. | by means of the appropriate isotopes injected into the spiny dogfish, squalus acanthias, the transfer of all major ions into cerebrospinal fluid (csf), aqueous humor (a) and endolymph (e) was studied. in addition, the effect of raising pco2 in sea-water upon hco3- concentration of these fluids was measured. in the several types of experiments, acetazolamide or methazolamide was used to inhibit completely carbonic anhydrase. the rates of fluid formation and ion transfer in csf and a were fairly c ... | 1977 | 15042 |
| a simplified decerebration technique in cats and its applicability to neuro-cardiovascular drug studies. | | 1977 | 15088 |
| control of hepatic and intestinal blood flow: effect of isovolaemic haemodilution on blood flow and oxygen uptake in the intact liver and intestines. | 1. limited isovolaemic haemodilution was produced in cats by addition of dextran 75-ringer solution to an extracorporeal blood reservoir connected in series with the cat. total hepatic venous outflow was neasured using a hepatic venous long-circuit and hepatic arterial flow was measured with an electromagnetic flow probe. oxygen uptake was monitored in the guts and liver. na-pentobarbitone anaesthesia was used. 2. following reduction of the haematocrit (from 31 to 22) the oxygen uptake of the gu ... | 1977 | 15108 |
| pharmacological studies of calcium blockers. | | 1977 | 15144 |
| action of adrenobloaking substances on the outflow of intraocular fluid. | | 1976 | 15229 |
| pharmacologic aspects of the problem of emotional stress. | | 1976 | 15233 |
| local mechanism of co2 action of cat pial arterioles. | the effect of local hypercapnic acidosis or local hypocapnic alkalosis on pial arterioles were studied in anesthetized cats equipped with a cranial window for the direct observation of the pial microcirculation of the parietal cortex. changes in pco2 and ph of the extracellular fluid were induced by perfusing the space under the cranial window with artificial cerebrospinal fluid equilibrated with different concentrations of co2, while paco2 was maintained constant. hypercapnic acidosis dilated a ... | 1977 | 15334 |
| possible functions of taurine in the central nervous system. | | 1976 | 15410 |
| the role of proline in nervous transmission. | | 1976 | 15411 |
| eelctrophysiological studies of the action of amino acid transmitters on spinal neurons in tissue culture. | | 1976 | 15414 |
| experimental study of a gentamicin aerosol. | the study of gentamicin aerosol showed its relative innocuousness: it did not inhibit the growth and development of young animals, did not induce pathological changes in the upper respiratory tract, kidneys, liver, heart and spleen on its prolonged use. pathohistological examination revealed slight irritating effect of the gentamicin aerosol in the lungs after its use in a dose of 8 or 25 mg/kg for 6 weeks. a procedure for investigating the effect of the aerosol on the activity of the trachea ci ... | 1977 | 15507 |
| aspects of the physiology and pharmacology of adrenergic transmission in the cat's spleen. | | 1975 | 15692 |
| the effects of labetalol (ah 5158) on adrenergic transmission in the cat spleen. | 1. the competitive alpha- and beta-adrenoceptor blocking agent labetalol, in concentrations up to 10(-4) m, produced dose-dependent increases in transmitter overflow from the isolated blood perfused spleen of the cat following nerve stimulation at 10 and 30 hz. 2. at concentrations above 10(-4) m labetol produced a pronounced decrease in transmitter overflow. 3. labetalol (1.5 x 10(-4) m) increased the recovery of 3h label in the venous blood following the close-arterial infusion of 3h-(-)-norad ... | 1977 | 15698 |
| activity of mammalian serium esterases towards malaoxon, fenitroxon and paraoxon. | | 1977 | 15778 |
| effect of narcotics on impulse conduction in the afferent pathways of visceral nerves. | in tests set up on cats immobilized with pyraxolone and anatruxonium the effect of non-inhalation narcotics on the evoked potentials of the cortex and subcortical structures with visceral and also somatic, acoustic and photo-stimulation was studied. with stimuli of different modality sodium ethaminal was found to inhibit evoked potentials of the cerebral hemispheres, diencephalon and midbrain cortex. hexabarbital sodium suppressed biopotentials in specific, associative and non- specific brain st ... | 1977 | 15858 |
| phencarol--an antihistaminic preparation from the quinuclidylcarbinol group. | a high antihistaminic activity of quinuclidyl-3-diphenylcarbinol (phencarol) has been ascertained. in pharmacological experiments phencarol is superior to dimedrol (diphenhydramine), both as concerns its antihistaminic activity and the duration of its action. unlike dimedrol and diprazine (promethazine) it has no inhibitory effect on the central nervous system. with its clinical use phencarol is effective in treating urticaria, quincke's edema and allergic skin reactions. the drug is well tolera ... | 1977 | 15861 |
| derivatives of dithiocarbamic acid as inhibitors of catecholamine biosynthesis (review of the literature). | | 1977 | 15863 |
| effects of ethosuximide on transmission of repetitive impulses and apparent rates of transmitter turnover in the spinal monosynaptic pathway. | the effects of ethosuximide on spinal monosynaptic transmission were studied in cats. the drug in doses of 200 or 400 mg/kg deepened the decline of monosynaptic response amplitude evoked by trains of 10 stimuli to a motor nerve at 2, 5 or 10 hz, without affecting the transmission of single isolated impulses. the patterns of decline were analyzed under the assumption that they reflect a partial depletion of the apparent transmitter stores in the presynaptic terminals, each incoming volley releasi ... | 1977 | 16119 |
| beta-adrenergic blocking agents. 15. 1-substituted ureidophenoxy-3-amino-2-propanols. | | 1977 | 16137 |
| use of coronaroactive agents with beta-stimulating effect in ischemic heart disease. | in feline experiments and 65 clinical cases of ischaemic heart disease the efficacy of a new beta-stimulating agetn -- ildamen -- was studied, the obtained effect was compared to that of euphillin. ildamen was found to be highly effective in patients with a moderately decreased coronary reserve and without atherosclerotic lesions in the coronary vessels. | 1976 | 16157 |
| the handing of h+ by the colon: the biophysical aspect of esophageal replacement. | | 1977 | 16166 |
| quantitative relationship between neurons of a different mediator nature in the motor nuclei of the cat spinal cord cervical thickening. | a histochemical analysis of the neuronal composition of the motor nuclei was performed on the cat cervical spinal cord. motoneurons were distinguished by the location of ache in the perinuclear space, on the membranes of the granular reticulum, on the axolemma, neurofilaments and neurotubuli, in the synaptosomes and the synaptic cleft; this evidences for the perinuclear synthesis of this enzyme and its transport within the axoplasm. their amount reached 40-65% of the whole neuronal population. a ... | 1977 | 16229 |
| pigment epithelial ensheathment and phagocytosis of extrafoveal cones in human retina. | the association between extrafoveal cone outer segments and pigment epithelial cells was studied by transmission electron microscopy in three human retinas; ages 5,45 and 60. the pigment epithelial apical surface from a fourth human retina, age 38,was viewed in the scanning electron microscope. multiple villous-like apical processes protrude from the pigment epithelium into the space above each cone. sometimes one or more of these processes is sheet-like in form and contains a wealth of intracel ... | 1977 | 16301 |
| analysis of vasoactivity of local ph, pco2 and bicarbonate on pial vessels. | the mechanism by which the local effect of co2on pial arterioles is exerted was examined in anesthetized cats equipped with a cranial window for the direct observation of the microcirculation of the parietal cortex. the dilation of pial arterioles in response to application of artificial cerebrospinal fluid with low ph was the same whether or not the pco2 of the solution was maintained in the normal range or markedly increased. the constriction of pial arterioles in response to application of ar ... | 1977 | 16363 |
| potential adrenoceptor active compounds. cis- and trans-3-hydroxy-4-isopropylaminochromans. | | 1977 | 16432 |
| worms: transmission from animals to man. | it is useful to know that household pets are not involved in the life cycles of some worms, for example, pinworms. some worms require a household pet in their cycles: the dog and cat roundworms, heartworms, and the dog and cat hookworms, the larvae of which are responsible for cutaneous larva migrans. strongyloides (threadworm) infestation is sometimes difficult to diagnose and may be traced directly to the family dog. | 1977 | 16475 |
| lactic acid as a factor in altering vascular reactivity. | it was shown that the constrictor responses to the electrostimulation of the isolated vessel segments were replaced by dilatation when the drugs were contained in the lactic acid solution. the capacity to constrictor effects was not lost completely, but these effects appeared in repsonse to the intensive stimulation. changes in the character of these reactions to the electrostimulation were connected with the changes in the ph of the solution, as well as with the specific action of lactic acid. | 1976 | 16674 |
| vascular beta-adrenoceptor stimulating properties of phenylephrine. | in pithed rats pretreated with propranolol changes occurred in the slopes of dose--pressor response curves to i.v. phenylephrine and noradrenaline but not to ld 3098, a pure alpha-adrenoceptor stimulant. in dogs, cats, and spontaneously hypertensive rats pretreated with an alpha-adrenoceptor blocker, i.v. phenylephrine induced vasodilatory responses which were antagonised by propranolol. these results indicate that phenylephrine, in addition to its known beta1-agonistic properties, stimulates th ... | 1977 | 16757 |
| purification of histamine receptor. (iv) specificity of binding of various drugs to the histamine receptor-rich fraction and to solubilized binding sites. | studies were made on tritiated histamine binding to the receptor-rich membrane fraction and solubilized sites and its displacement by various drugs. h1-agonists and antagonists displaced histamine most effectively. a h2-agonist and atropine were less effective and propranolol, phentolamine and imidazole acetic acid had little effect. the solubilized binding sites showed the same specificity of binding as the membrane fraction. membrane fragments had two binding constants, whereas solubilized sit ... | 1977 | 17028 |
| a new antihypertensive compound: 3 hydrazino-6- (2-hydroxypropyl)methylamino pyridazine dihydrochloride (isf 2123). | | 1976 | 17122 |
| role of salivary ribonuclease in pathogenesis of periodontosis. | in patients with periodontal disease a distinct increase in secretion of salivary acidic and alkaline rnaases was found. the rnaases activity in mixed saliva correlated with the intensity of degradation of periodontal tissues during loss of alveolar layer in aged wistar rats and the spontaneous periodontal disease in cats. in experiments with golden hamsters salivary rnaase was found to penetrate through mucosa in active form. the purified salivary rnaase inhibited the protein biosynthesis in ra ... | 1976 | 17223 |
| pharmacologic incompatibility of neuroleptics and tranquilizers with other medicines. | | 1977 | 17255 |
| brugian filariasis: epidemiological and experimental studies. | | 1977 | 17276 |
| putative peptide neurotransmitters. | | 1977 | 17359 |
| psychopharmacological implications of dopamine and dopamine antagonists: a critical evaluation of current evidence. | | 1977 | 17361 |
| influence of h+ on k+ on adenosine-induced dilatation at pial arteries of cats. | the influence of changes in the perivascular k+ and h+ concentrations upon adenosine-induced dilatations of pial arteries was investigated by localized perivascular application using micropuncture technique. adenosine (10(-9)-10(-3) m) was dissolved in mock spinal fluids with varying bicarbonate and potassium concentrations (5 and 22 mm hco3-, and 6 and 10 mm k+). concentration response curves revealed that adenosine induced the same change in pial arterial diameter when dissolved either in an i ... | 1977 | 17441 |
| the interaction between clonidine and various neuroleptic agents and some benzodiazepine tranquillizers. | the central hypotensive action of clonidine, infused into the vertebral artery of chloralose-anaesthetized cats was antagonized by several phenothiazine-neuroleptics (chlorpromazine, promazine, promethazine, thiethylperazine, thioridazine), by chlorprothixene and to a limited extent by haloperidol administered via the same route. pimozide and some benzodiazepines (chlordiazepoxide, diazepam and flurazepam) hardly influenced the central hypotensive response to clonidine. the antagonism between cl ... | 1977 | 17673 |
| the effects of paracetamol on temperature and cardiovascular changes caused by pyrogenic contamination of chronically implanted arterial cannulae in the conscious, renal hypertensive cat. | | 1977 | 17697 |
| phosphonic analogues as antagonists of amino acid excitants. | | 1977 | 17707 |
| regulation of cerebrospinal fluid bicarbonate by the cat choroid plexus. | 1. the regulation of cerebrospinal fluid (c.s.f.) bicarbonate concentration was studied using the cat choroid plexus isolated in a chamber in situ. 2. decreases in plasma bicarbonate concentration caused relatively small changes in the c.s.f. bicarbonate concentration. 3. alterations in c.s.f. bicarbonate concentration (c.s.f. hco3-=9 or 28 m-equiv/l.) were countered by changes in the bicarbonate concentration of the fluid produced by the plexus or in the rate of bicarbonate transport which retu ... | 1977 | 17733 |
| hyperpolarizing effects of dopamine on chemoreceptor nerve endings from cat and rabbit carotid bodies in vitro. | 1. the effects of dopamine on dc potential changes recorded from the carotid sinus nerve were studied in vitro using carotid bodies and associated sinus nerves removed from anaesthetized cats and rabbits.2. the carotid body was placed in one compartment of a superfusion chamber and was superfused with buffered salt solution. the carotid sinus nerve was led into an adjoining compartment, containing lightweight mineral oil, for recording dc potential changes with chlorided silver electrodes.3. dop ... | 1977 | 17742 |
| the effects on breathing of alternate breaths of air and a carbon dioxide rich gas mixture in anaesthetized cats. | 1. an in vivo ph electrode was used to assess the effect in anaesthetized cats of the administration of 5% co(2) (21% o(2), balance n(2)) and air as alternate inspirates upon the time course of the carotid arterial ph, and by inference, the p(co2).2. this method of administration of co(2) and air resulted in a lowering of the recorded ph with the production of oscillations of twice the duration seen on air alone. these larger oscillations had a period of two respiratory cycles and their amplitud ... | 1977 | 17744 |
| beta-adrenoceptor blocking activity of halogenated thienylethanolamine derivatives. | the synthesis of a number of ring-halogenated n-isopropyl- and n-tert-butyl-2-amino-1-(2-thienyl)ethanols has been carried out in order to ascertain the influence of chloro or bromo substitution at the thiophene moiety on their blocking beta-adrenoceptor activity. it was found that chloro- and bromo-substituted compounds exhibited a similar activity. monohalo substitution at positions c4 or c5 of the thiophene ring resulted in comparable blocking potency, whereas c3 halo-substituted compounds we ... | 1977 | 17752 |
| prevention of brain tissue hypoxia by intrathecal injection of oxygenated fluorocarbon. | | 1977 | 17811 |
| hypoxia in skeletal muscle at rest and during the transition to steady work. | | 1977 | 17813 |
| ion fluxes in hypoxic tissues. | | 1977 | 17814 |
| the speed of passive dendritic conduction of synaptic potentials in a model montoneurone. | | 1977 | 17867 |
| pineal vasotocin: release into cat cerebrospinal fluid by melanocyte-stimulating hormone release-inhibiting factor. | the intracarotid injection of both synthetic melanocyte-stimulating hormone release-inhibiting factor (mif) and purified mif prepared from bovine hypothalami induces arginine vasotocin release into cerebrospinal fluid of cats and significantly decreases the pineal arginine vasotocin content at 5 minutes after the injection. the present results demonstrate an extrapituitary endocrine effect of synthetic and purified bovine mif. | 1977 | 17916 |
| aspartate transfer across the blood-retina barrier (author's transl). | permeability of the blood-brain barrier is restricted with respect to amino acids involved in neurotransmission. this finding is well-documented in the case of gamma-amino-butyric acid (gaba) and glycine. aspartic acid, which is also considered to be a transmitter, equally does not cross the blood-brain barrier in the rat with ease. this amino acid is also thought to be a transmitter in the retina. in order to examine the permeability of the blood-retina barrier with respect to aspartic acid, an ... | 1977 | 17948 |