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the accessory optic system of the rabbit, cat, dog and monkey; a whole-mount hrp study.the three-dimensional fiber pathways of the accessory optic system in the rabbit, cat, dog and monkey were studied in whole-mounted preparations of the diencephalon and the midbrain, without sectioning, by anterograde labeling of retinal axons with horseradish peroxidase (hrp). hrp histochemical studies on alternate serial coronal sections were also performed. the rabbit accessory optic system exhibited two fasciculi (the inferior fasciculus, and the superior fasciculus consisting of the anterio ...19882451451
substance p-like immunoreactive retinal terminals found in two retinorecipient areas of the japanese monkey.using peroxidase-antiperoxidase immunocytochemistry, we demonstrated a dense accumulation of substance p-like (sp) immunoreactive terminals in the internal layer of the pregeniculate nucleus and in the pretectal olivary nucleus of the japanese monkey. these distributions of immunostaining were similar to those for retinofugal terminals in the same nuclei. bilateral eye enucleation markedly decreased sp immunoreactivity in the nuclei. the reduced immunoreactivity probably reflected the loss of sp ...19882463501
uh series of monoclonal antibodies recognizing major histocompatibility complex class ii antigen(s) of japanese monkeys (macaca fuscata).six mouse monoclonal antibodies were developed by immunization with a japanese monkey cell line. these monoclonal antibodies, designated the uh series, reacted with large populations of peripheral b cells and monocytes, but not with t cells. the distribution of reactivities and the molecular weight of the membrane antigens recognized were similar to those of the hla-dr monoclonal antibody; one inhibited the binding of hla-dr. human interferon-gamma induced increased expressions of all the uh ant ...19892469798
uh series of monoclonal antibodies recognizing major histocompatibility complex class ii antigen(s) of japanese monkeys (macaca fuscata).six mouse monoclonal antibodies were developed by immunization with a japanese monkey cell line. these monoclonal antibodies, designated the uh series, reacted with large populations of peripheral b cells and monocytes, but not with t cells. the distribution of reactivities and the molecular weight of the membrane antigens recognized were similar to those of the hla-dr monoclonal antibody; one inhibited the binding of hla-dr. human interferon-gamma induced increased expressions of all the uh ant ...19892469798
neurokinin a-induced bronchial hyperresponsiveness to methacholine in japanese monkeys.the present study was designed to investigate whether neurokinin a (nka) and substance p (sp) increase bronchial responsiveness to methacholine (mch). before and 1, 2, 3 and 4 weeks after three japanese monkeys had inhaled 10(-8) m nka and 10(-8) m sp for 2 min, bronchial responsiveness to inhaled mch was evaluated. pulmonary flow resistance (r1) and dynamic lung compliance (cdyn) were used as pulmonary function tests. dose-response curves of r1 to inhaled mch were shifted to the left 1 to 4 wee ...19892479121
neurokinin a-induced bronchial hyperresponsiveness to methacholine in japanese monkeys.the present study was designed to investigate whether neurokinin a (nka) and substance p (sp) increase bronchial responsiveness to methacholine (mch). before and 1, 2, 3 and 4 weeks after three japanese monkeys had inhaled 10(-8) m nka and 10(-8) m sp for 2 min, bronchial responsiveness to inhaled mch was evaluated. pulmonary flow resistance (r1) and dynamic lung compliance (cdyn) were used as pulmonary function tests. dose-response curves of r1 to inhaled mch were shifted to the left 1 to 4 wee ...19892479121
[changes of microvascular patterns of the palatine mucosa under the denture base].microvascular changes of the denture-bearing mucosa on the hard palate of japanese monkeys (macaca fuscata) were investigated on microvascular casts utilizing the acryl plastic injection method (taniguchi, ohta et al. 1952, 1955) under sem and ultrastructure of the endothelium of the blood capillary and surrounding tissues under tem. the results obtained were as follows: 1. sem findings of microvascular casts were by 10 days after setting the experimental denture capillary loops appeared a simpl ...19892489729
[changes of microvascular patterns of the palatine mucosa under the denture base].microvascular changes of the denture-bearing mucosa on the hard palate of japanese monkeys (macaca fuscata) were investigated on microvascular casts utilizing the acryl plastic injection method (taniguchi, ohta et al. 1952, 1955) under sem and ultrastructure of the endothelium of the blood capillary and surrounding tissues under tem. the results obtained were as follows: 1. sem findings of microvascular casts were by 10 days after setting the experimental denture capillary loops appeared a simpl ...19892489729
species identification of blood and bloodstains by enzyme-linked immunosorbent assay (elisa) using anti-human immunoglobulin kappa light chain monoclonal antibody.a series of experiments was conducted to establish a species identification method by means of the enzyme-linked immunosorbent assay (elisa) using monoclonal antibody with high specificity, the result of which is reported. the limit of human igg detection by inhibition elisa using mouse anti-human immunoglobulin kappa light chain (ig kappa) monoclonal antibody is 0.01 microgram. using this method it was possible to detect human ig kappa from bloodstains in dilutions up to 1:100,000 (dilution mul ...19892494103
functional analysis of the biceps femoris muscle during locomotor behavior in some primates.in order to investigate a correlation between morphological variations of the biceps femoris muscle and its homologues in four primate species (japanese macaque, spider monkey, white-handed gibbon, and chimpanzee) and each type of species-specific locomotor behavior, i carried out both morphological and functional analyses of these muscles. the description of the level of insertion reveals interspecific variation is in the level of crural attachment, especially in species with a bicipital biceps ...19892504047
[roentogenologic pathologic evaluation of allograft rejection in heart-lung transplantation--an experimental study in japanese monkey].experimental heart-lung transplantation was carried out in japanese monkey (macaca fuscata). twelve monkeys survived two to thirty-three days. pathologic examination of the lung was performed at the time of open lung biopsy and autopsy. postoperative chest roentogenogram was also studied in seven monkeys. in the early postoperative period, central cloudiness and enhancement of the interstitial change were observed, which started from the second or third postoperative day and reached their peak b ...19892504844
thalamic mechanism of pain: shell theory of thalamic nociception.in both cats and japanese macaques, there are nociceptive specific (ns) and wide dynamic range (wdr) neurons in the shell region of the caudal ventrobasal (vb) complex of the thalamus. this comprises both the nucleus ventralis posteromedialis proper (vpm proper), and the nucleus ventralis posterolateralis (vpl). these two classes of nociceptive neurons are spatially segregated, wdr neurons being located both more anteriorly and in a narrow belt around the vb complex. both ns and wdr neurons are ...19892507813
chronically streptozocin-diabetic monkey does not closely mimic human diabetic neuropathy.in order to evaluate the value of diabetic japanese monkeys (macaca fuscatus) as an animal model for studying the pathogenesis of diabetic neuropathy, morphological examinations were performed on myelinated nerve fibers and endoneurial microvessels at three levels of the lower limb nerve in eight streptozocin (stz)-diabetic monkeys with the duration of diabetes up to 36 months and in four roughly age-matched control monkeys using a computer-assisted image analyzer. nerve fiber loss was not found ...19892523314
chronically streptozocin-diabetic monkey does not closely mimic human diabetic neuropathy.in order to evaluate the value of diabetic japanese monkeys (macaca fuscatus) as an animal model for studying the pathogenesis of diabetic neuropathy, morphological examinations were performed on myelinated nerve fibers and endoneurial microvessels at three levels of the lower limb nerve in eight streptozocin (stz)-diabetic monkeys with the duration of diabetes up to 36 months and in four roughly age-matched control monkeys using a computer-assisted image analyzer. nerve fiber loss was not found ...19892523314
cd16+ lymphoblastic cell lines of crab-eating monkeys (macaca fascicularis) shared u-5 antigen and expressed natural killer activity.the cd16+ lymphoblastic cell lines of crab-eating monkeys shared the u-5 antigen recognized by a monoclonal antibody. the cd16+u-5+ cell lines expressed high natural killer activity to k562 cells, whereas the cd16-u-5- control cell line had no significant natural killer activity. a possible involvement of the u-5 antigen in natural killer function was also suggested by reduction of the natural killer activity in peripheral blood mononuclear cells of japanese monkeys after treatment with u-5 mono ...19892533266
cd16+ lymphoblastic cell lines of crab-eating monkeys (macaca fascicularis) shared u-5 antigen and expressed natural killer activity.the cd16+ lymphoblastic cell lines of crab-eating monkeys shared the u-5 antigen recognized by a monoclonal antibody. the cd16+u-5+ cell lines expressed high natural killer activity to k562 cells, whereas the cd16-u-5- control cell line had no significant natural killer activity. a possible involvement of the u-5 antigen in natural killer function was also suggested by reduction of the natural killer activity in peripheral blood mononuclear cells of japanese monkeys after treatment with u-5 mono ...19892533266
structure of the major o-glycosidic oligosaccharide of monkey erythrocyte glycophorin.sialic acids and the major o-glycosidic oligosaccharide of glycophorin mk from monkey (japanese monkey, macaca fuscata) erythrocyte membranes were characterized. n-glycolylneuraminic acid (neu5gc) was found as the major sialic acid, which was confirmed by gas-liquid chromatography-mass spectrometry as the trimethylsilyl methyl ester. three o-glycosidic oligosaccharide units were obtained from a tryptic glycopeptide that contained all of the carbohydrate units in glycophorin mk by mild alkaline b ...19892535496
nasotemporal overlap of crossed and uncrossed retinal ganglion cell projections in the japanese monkey (macaca fuscata).the nasotemporal overlap of crossed and uncrossed retinal ganglion cell projections were studied in 11 japanese monkeys (macaca fuscata) using hrp and fluorescent dyes (dapi and ritc) as retrograde tracers and by physiological recordings of antidromic field potentials. a strip of nasotemporal overlap ran orthogonal to the horizontal meridian in all the whole-mount retinas studied. in hrp-labeled retinas of 6 monkeys, the width of the overlap gradually increased from 0.6 degrees in the central re ...19892545836
nasotemporal overlap of crossed and uncrossed retinal ganglion cell projections in the japanese monkey (macaca fuscata).the nasotemporal overlap of crossed and uncrossed retinal ganglion cell projections were studied in 11 japanese monkeys (macaca fuscata) using hrp and fluorescent dyes (dapi and ritc) as retrograde tracers and by physiological recordings of antidromic field potentials. a strip of nasotemporal overlap ran orthogonal to the horizontal meridian in all the whole-mount retinas studied. in hrp-labeled retinas of 6 monkeys, the width of the overlap gradually increased from 0.6 degrees in the central re ...19892545836
immunological and molecular comparison of simian cytomegaloviruses isolated from african green monkey (cercopithecus aethiops) and japanese macaque (macaca fuscata).simian cytomegaloviruses (cmv) isolated from african green monkeys and japanese macaques were compared serologically and genetically. twenty-three out of 31 sera from japanese, taiwan and rhesus macaques were positive for neutralizing antibodies to simian cmvs isolated from both african green monkeys and a japanese macaque. the neutralizing antibody titers of those sera were slightly higher to the isolates of african green monkeys origin than to that of japanese macaque origin. studies with anti ...19892552962
isolation of simian retroviruses closely related to human t-cell leukemia virus by establishment of lymphoid cell lines from various non-human primates.simian retroviruses closely related to human t-cell leukemia virus (htlv) were isolated by establishing virus-producing lymphoid cell lines from 7 species of non-human primates. by co-cultivation with human umbilical cord-blood cells and/or in the presence of interleukin-2, lymphoid cell lines were successfully established from the chimpanzee. african green monkey, pig-tailed macaque, red-faced macaque, formosan monkey, japanese monkey and bonnet monkey that had antibodies against htlv antigens. ...19852579038
[histochemical demonstration of proteins, lipids and polysaccharides in japanese monkey oocytes].a histochemical study of proteins, lipids and polysaccharides was carried out in the oocytes of japanese monkey (macaca fuscata) during development of follicles. there were a small number of protein granules reactive to acrolein-schiff in the cytoplasm of oocytes from primordial, secondary and vesicular follicles, while there were no lipid droplets, granules of neutral polysaccharides or acid polysaccharides in the cytoplasm. proteins reactive to acrolein-schiff, neutral polysaccharides reactive ...19852580728
[effects of an anti-prostaglandin agent added to the irrigation solution on damage to the anterior segment in monkey eyes induced by pars plana vitrectomy].flurbiprofen is a water-soluble, non-steroid anti-inflammatory agent and is capable of marked inhibition of prostaglandin synthesis. in a previous study by the authors, it was determined that the optimum concentration of flurbiprofen for intraocular irrigation solution in monkey retinas is 4 to 40 micrograms/ml. the present study was conducted to determine the optimum concentration of flurbiprofen for the irrigation solution, as well as to evaluate its toxic effects on the anterior segment tissu ...19892610162
[effects of an anti-prostaglandin agent added to the irrigation solution on damage to the anterior segment in monkey eyes induced by pars plana vitrectomy].flurbiprofen is a water-soluble, non-steroid anti-inflammatory agent and is capable of marked inhibition of prostaglandin synthesis. in a previous study by the authors, it was determined that the optimum concentration of flurbiprofen for intraocular irrigation solution in monkey retinas is 4 to 40 micrograms/ml. the present study was conducted to determine the optimum concentration of flurbiprofen for the irrigation solution, as well as to evaluate its toxic effects on the anterior segment tissu ...19892610162
[optic disc measurements with computerized image analysis in experimental chronic glaucoma].we quantitatively analyzed morphological changes of the optic disc of ten japanese monkey eyes exposed to sustained intraocular pressure (iop) elevation by repeated argon laser application to the trabecular meshwork. using a computerized image analyzer (topcon imagenet), we measure the cup-disc ratio (cdr), disc area (da), cup volume/disc area (cv/da), and rim area/disc area (ra/da). the duration of iop elevation was 48.4 +/- 0.8 (mean +/- sd) weeks, and the mean iop during the experiment was 26 ...19892610166
[macular diseases in the elderly person].macular diseases in the elderly, such as age-related macular degeneration, idiopathic senile macular hole and epiretinal membrane of the macular area were studied. in 75 normal subjects aged from 20 to 78 years, retinal sensitivity in the central 10 degree visual field were examined using automated static quantitative perimetry. for background luminance of 31.5 asb, a significant reciprocal correlation was demonstrated between individual mean sensitivity and age. the influence of age on the decr ...19892610169
[metrical study on teeth and mandible in macaca fuscata fuscata. 2. principal component analysis].metrical investigation on teeth and mandible together was performed to understand the morphological relationship between these two components in macaca fuscata fuscata. measurements are 9 items from the mandible, 2 items from dental arch, and 8 mesiodistal diameters from teeth. correlation matrix composed of 19 items, in total, was examined in males and females, respectively. significant correlation coefficients were frequently seen among mandibular measurements and also among tooth measurements ...19892626163
[histochemical properties of secretory granules and fine structure of terminal portion in the japanese macaque labial gland].the terminal portion of the japanese macaque (macaca fuscata) labial gland was examined ultrastructurally and histochemically. the results obtained are as follows. 1) the japanese macaque, macaca fuscata has the upper and the lower labial glands, which can be described as a compound tubulo-acinar gland. 2) the terminal portion of the labial gland appears to be consisted of the mucous acini and the demilunes when examined with the light microscope. 3) the secretory granules containing in the glan ...19892637414
enamel hypomineralization viewed from the pattern of progressive mineralization of human and monkey developing enamel.microradiograms and their computer-aided image analysis of ground sections of the developing enamel of human permanent third molars and monkey permanent teeth (macaca fuscata) indicate that the mode of progressive mineralization of enamel is completely different between the matrix formation and maturation stages. during the former stage, the enamel matrix is slightly mineralized. during the latter stage, which takes a much longer period than the previous stage, the increase in the secondary mine ...19892640430
[effect of two stage corticotomy on maxillary protraction].for the purpose of clarifying the effects of two stage corticotomy on maxillary protraction, experimental studies by using of 5 male japanese monkeys (macaca fuscata) were performed. results from cast analysis, roentgenographic cephalometry and histological examinations were as follows. i. in experimental groups that received two stage corticotomy with maxillary protraction, apical base of maxillary bone protruded markedly. ii. in control groups that maxillary protraction was applied without cor ...19892640929
[effect of two stage corticotomy on maxillary protraction].for the purpose of clarifying the effects of two stage corticotomy on maxillary protraction, experimental studies by using of 5 male japanese monkeys (macaca fuscata) were performed. results from cast analysis, roentgenographic cephalometry and histological examinations were as follows. i. in experimental groups that received two stage corticotomy with maxillary protraction, apical base of maxillary bone protruded markedly. ii. in control groups that maxillary protraction was applied without cor ...19892640929
an orally active renin inhibitor: cyclohexylnorstatine-containing dipeptide (kri-1314).in our continuing search for low molecular weight, human renin inhibitors, a dipeptide derivative, morpholino-naphthyl-acyl-histidyl-cyclohexyl-norstatine (kri-1314), was newly synthesized and estimated for oral effectiveness. this compound inhibited plasma renin from humans and from japanese monkeys in vitro, with 50% inhibitory concentrations (ic50) of 4.7 x 10(-9) and 2.4 x 10(-8) mol/l, respectively. the mean blood pressure of sodium-depleted japanese monkeys was lowered significantly after ...19892666609
an orally active renin inhibitor: cyclohexylnorstatine-containing dipeptide (kri-1314).in our continuing search for low molecular weight, human renin inhibitors, a dipeptide derivative, morpholino-naphthyl-acyl-histidyl-cyclohexyl-norstatine (kri-1314), was newly synthesized and estimated for oral effectiveness. this compound inhibited plasma renin from humans and from japanese monkeys in vitro, with 50% inhibitory concentrations (ic50) of 4.7 x 10(-9) and 2.4 x 10(-8) mol/l, respectively. the mean blood pressure of sodium-depleted japanese monkeys was lowered significantly after ...19892666609
natural infection with canine distemper virus in a japanese monkey (macaca fuscata).a case of encephalitis in a japanese monkey (macaca fuscata) was examined histopathologically and serologically. the animal had brain lesions consisting of perivascular cuffs, malacia, inclusion bodies and giant cells. monoclonal antibody to the nucleoprotein of canine distemper virus (cdv) stained the inclusions, and the distribution of the virus antigen was closely associated with that of the histological lesions. serologically, all the 22 monkeys in the same group as the diseased monkey had r ...19892672547
natural infection with canine distemper virus in a japanese monkey (macaca fuscata).a case of encephalitis in a japanese monkey (macaca fuscata) was examined histopathologically and serologically. the animal had brain lesions consisting of perivascular cuffs, malacia, inclusion bodies and giant cells. monoclonal antibody to the nucleoprotein of canine distemper virus (cdv) stained the inclusions, and the distribution of the virus antigen was closely associated with that of the histological lesions. serologically, all the 22 monkeys in the same group as the diseased monkey had r ...19892672547
digit-muscle responses evoked from multiple intracortical foci in monkey precentral motor cortex.1. the precentral motor cortex, including the anterior bank of the central sulcus of monkey (macaca fuscata), was systemically penetrated with microelectrodes to determine the spatial organization of the microexcitable cortical elements that can produce responses in digit muscles. 2. at 200-microns intervals on each electrode track, low-current intracortical microstimuli were delivered and the muscle responses evoked from four digit muscles were recorded. the responses, obtained with 5, 8, 15, a ...19892681562
modified endoplasmic reticulum in taste bud cells of the japanese monkey.type iii cells (receptor cells) in taste buds of vallate papillae in the japanese monkey often have one or more cytoplasmic bodies composed of modified smooth endoplasmic reticulum in the form of concentric smooth-surfaced cisternae, up to 18 in number. the most peripheral cisternae may be in continuity with rough endoplasmic reticulum (rer). type ii cells have dilated rer cisternae that often contain crystalline plates with an axial periodicity that ranges from 17 to 27 nm. these observations s ...19892702610
occurrence of yersinia enterocolitica in the tokyo tama zoo.yersinia enterocolitica serogroups o5a and o8 were isolated from fecal samples of one colony of japanese macaques (macaca fuscata) from the tokyo tama zoo (japan). serogroup o5a was detected in brown bear (ursus arctos) prior to the isolation from the macaques. serogroup o5a organisms also were isolated from the japanese macaques' breeding area. serogroup o5a and o8 isolates were not pathogenic. serogroup o8 isolates did not possess the o7 or o19 antigens.19892716113
oral cavity representation at the frontal operculum of macaque monkeys.receptive properties of neurons at areas 3 and 1-2, and the gustatory area (area g) in the frontal operculum (fop) and the neighboring areas were investigated in the cerebral cortex of macaca irus and macaca fuscata by applying mechanical and taste stimulation to the oral cavity and lips. tactile neurons with different receptive properties were noted in areas 3, 1-2 and g. areas 3 and g were packed with tongue neurons, though a considerable number of palate neurons were also found in area g, whi ...19892725988
reflex regulation of the sphincter of oddi by intrapancreatic ductal pressure in the japanese monkey.japanese monkey has a common ampullary channel. by a continuous injection of sterile saline (1 ml/min) into the pancreatic main duct, the pancreatic main ductal pressure increased from 8.4 +/- 1.0 (mean +/- sd) to a plateau level (16-25 mmhg) in 5 japanese monkeys. the frequency and amplitude of the slow wave in electromyography of the sphincter of oddi (so) were significantly decreased from 14 to 2/min and 0.06 to 0.04 mv (p less than 0.01), and the frequency of the spike component significantl ...19892732530
reflex regulation of the sphincter of oddi by intrapancreatic ductal pressure in the japanese monkey.japanese monkey has a common ampullary channel. by a continuous injection of sterile saline (1 ml/min) into the pancreatic main duct, the pancreatic main ductal pressure increased from 8.4 +/- 1.0 (mean +/- sd) to a plateau level (16-25 mmhg) in 5 japanese monkeys. the frequency and amplitude of the slow wave in electromyography of the sphincter of oddi (so) were significantly decreased from 14 to 2/min and 0.06 to 0.04 mv (p less than 0.01), and the frequency of the spike component significantl ...19892732530
[qualitative and quantitative changes of luteinizing hormone (lh) in the pituitary glands in female japanese monkeys (macaca fuscata) during the menstrual cycle and after castration].the present study was designed to investigate qualitative and quantitative changes in luteinizing hormone (lh) in the pituitary glands of female japanese monkeys (macaca fuscata) during the menstrual cycle and after castration. the pituitary glands were removed from 10 intact cycling japanese monkeys and 3 castrated ones: the former sacrificed in the early, late follicular phase, and mid luteal phase, and the latter 8 weeks after castration. all 13 pituitary glands were fractionated by isoelectr ...19892732558
[qualitative and quantitative changes of luteinizing hormone (lh) in the pituitary glands in female japanese monkeys (macaca fuscata) during the menstrual cycle and after castration].the present study was designed to investigate qualitative and quantitative changes in luteinizing hormone (lh) in the pituitary glands of female japanese monkeys (macaca fuscata) during the menstrual cycle and after castration. the pituitary glands were removed from 10 intact cycling japanese monkeys and 3 castrated ones: the former sacrificed in the early, late follicular phase, and mid luteal phase, and the latter 8 weeks after castration. all 13 pituitary glands were fractionated by isoelectr ...19892732558
microvascular patterns of the hard palatine mucosa in the japanese monkey (macaca fuscata).detailed investigations were made of the microvasculature of the mucous membrane, especially the transverse palatine plicae, of the hard palate of the japanese monkey (macaca fuscata) utilizing the plastic injection method. the microvascular patterns obtained were compared with those of the cat and other mammals. the incisive papilla was located at the anterior end of the median line of the hard palate, and seven or eight transverse palatine plicae were observed symmetrically from this papilla p ...19892733984
[changes in the microvascular patterns during the osseous healing of the tooth extraction wounds].successive changes in the vascular pattern during the osseous healing of extraction wounds were investigated by studying microvascular casts under a scanning electron microscope. the casts were prepared utilizing the plastic injection method, after the extraction of the upper four incisors of the japanese monkey (macaca fuscata). five days after extraction, vascular buds have sprouted from a pre-existing blood vessel on the alveolar wall into the blood clot, and leakage of the plastic injected w ...19892519250
retinogeniculate projection fibers in the monkey optic nerve: a demonstration of the fiber pathways by retrograde axonal transport of wga-hrp.seven japanese monkeys (macaca fuscata) were used to investigate the fiber pathways of the optic nerve. optic nerve fibers and retinal ganglion cells were retrogradely labeled by iontophoretic injections of wheat germ agglutinin conjugated to horseradish peroxidase (wga-hrp) into electrophysiologically defined positions of the lateral geniculate nucleus (lgn). by gross anatomical observation, the optic nerve usually had one distinct bend, which flexed dorsally 3-4 mm from the eyeball, and occasi ...19892474002
retinogeniculate projection fibers in the monkey optic nerve: a demonstration of the fiber pathways by retrograde axonal transport of wga-hrp.seven japanese monkeys (macaca fuscata) were used to investigate the fiber pathways of the optic nerve. optic nerve fibers and retinal ganglion cells were retrogradely labeled by iontophoretic injections of wheat germ agglutinin conjugated to horseradish peroxidase (wga-hrp) into electrophysiologically defined positions of the lateral geniculate nucleus (lgn). by gross anatomical observation, the optic nerve usually had one distinct bend, which flexed dorsally 3-4 mm from the eyeball, and occasi ...19892474002
the distribution of substance p in the cerebral cortex and hippocampal formation: an immunohistochemical study in the monkey and rat.the distribution of substance p-containing fibers in the cerebral cortex and the hippocampal formation of the japanese monkey (macaca fuscata fuscata) was studied by immunohistochemistry using a monoclonal antibody raised against substance p. the results were compared with the distribution in homologous regions of the rat brain. substance p-containing fibers and cell bodies were observed in all regions of the cerebral cortex. in deep layers of the neocortex (iv-vi), substance p-immunoreactive fi ...19892468400
direct projections from the subthalamic nucleus of luys to the spinal cord in the japanese monkey.injection of large amounts of a mixture of horseradish peroxidase and wheat germ agglutinin-horseradish peroxidase conjugate into the upper cervical segments of the spinal cord in the japanese monkey (macaca fuscata) led to the retrograde labeling of a small number of neuronal cell bodies within the rostral part of the subthalamic nucleus of luys. direct projection from the subthalamic nucleus to the spinal cord appeared to be much less prominent in the japanese monkey than in the cat and rat.19882456494
na,k-atpase activity and repolarization of ventricular action potentials in simian hearts.we measured na,k-atpase activity and atp content of 4 different areas of the left ventricular muscle of japanese monkeys (mucaca fuscata): the apex, base, and epicardium (epi) and endocardium (endo) of the free wall. we compared those values with electrical parameters such as action potential duration (apd) and the level of resing potentials. apds of base and endo were significantly longer than those of apex and epi, respectively. there was no significant difference in atp contents among the fou ...19862434675
na,k-atpase activity and repolarization of ventricular action potentials in simian hearts.we measured na,k-atpase activity and atp content of 4 different areas of the left ventricular muscle of japanese monkeys (mucaca fuscata): the apex, base, and epicardium (epi) and endocardium (endo) of the free wall. we compared those values with electrical parameters such as action potential duration (apd) and the level of resing potentials. apds of base and endo were significantly longer than those of apex and epi, respectively. there was no significant difference in atp contents among the fou ...19862434675
representation of the tensor veli palatini muscle in the trigeminal motor nucleus of the japanese monkey (macaca fuscata).distribution of motoneurons supplying the tensor veli palatini (tvp) muscle was examined in the japanese monkey (macaca fuscata) by the retrograde horseradish peroxidase (hrp) method. neurons labeled with hrp which was injected into the tensor veli palatini muscle were seen in the ventromedial aspects of the dorsolateral division of the trigeminal motor nucleus, at all rostrocaudal levels of the trigeminal motor nucleus. the vast majority of these tvp motoneurons were distributed around the marg ...19902366953
immunoreactive inhibin levels in peripheral blood during the breeding season in the female japanese monkey.serum levels of immunoreactive inhibin as well as fsh, lh, estradiol-17 beta, and progesterone were measured by ria in four mature female japanese monkeys (macaca fuscata fuscata) during the breeding season and subsequent transition into the nonbreeding season. during the breeding season, each monkey showed 2-6 ovulations, which were inferred from underlying endocrine events. the concentrations of serum inhibin increased during the luteal phase, but were low during the follicular phase. such cha ...19902116190
immunoreactive inhibin levels in peripheral blood during the breeding season in the female japanese monkey.serum levels of immunoreactive inhibin as well as fsh, lh, estradiol-17 beta, and progesterone were measured by ria in four mature female japanese monkeys (macaca fuscata fuscata) during the breeding season and subsequent transition into the nonbreeding season. during the breeding season, each monkey showed 2-6 ovulations, which were inferred from underlying endocrine events. the concentrations of serum inhibin increased during the luteal phase, but were low during the follicular phase. such cha ...19902116190
[alcohol drinking behaviors--physiological and sociomedical factors].alcohol drinking behavior is usually studied from two perspectives, factors leading to drinking behavior and the behavioral effects of alcohol drinking. many detailed medicolegal, pharmacological and psychiatric studies have been conducted on the behavioral effects of alcohol drinking. few studies have considered the biological aspects of a desire for alcohol. however, these issues can not be ignored. the role of genetic, environmental and nutritional factors in alcohol preference has extensivel ...19902079763
[alcohol drinking behaviors--physiological and sociomedical factors].alcohol drinking behavior is usually studied from two perspectives, factors leading to drinking behavior and the behavioral effects of alcohol drinking. many detailed medicolegal, pharmacological and psychiatric studies have been conducted on the behavioral effects of alcohol drinking. few studies have considered the biological aspects of a desire for alcohol. however, these issues can not be ignored. the role of genetic, environmental and nutritional factors in alcohol preference has extensivel ...19902079763
the jump as a fast mode of locomotion in arboreal and terrestrial biotopes.the jump is always used for locomotion. for its execution in arboreal and terrestrial biotopes the requirements are of somewhat different nature. in an arboreal biotope the jump is characterized by a rapid progression through discontinuous substrates and the ability to take off from a small area and a secure landing on a spot. this requires well coordinated movements in all phases of the jump. on the ground, the jump is less frequent and often used for crossing obstacles or gaps. in primates bot ...19911887664
conscious sedation and analgesia with rectal ketamine in the macaca fuscata monkey.conscious sedation is commonly utilized in pediatric dentistry. although opioid analgesics are often employed, patient safety would be enhanced if nonopioid drugs were used. the purpose of this study was to determine if rectal ketamine could produce plasma concentrations that would achieve both conscious sedation and analgesia to gingival needle puncture. five 2-year-old male macaca fuscata monkeys were given rectal ketamine at a dosage of 60 mg/kg and 90 mg/kg one week apart. blood was drawn at ...19911811429
species differences in the coexistence of 5-hydroxytryptamine and substance p in presynaptic boutons in the cervical ventral horn.substance p (sp)- and 5-hydroxytryptamine (5-ht)-containing presynaptic boutons in the cervical ventral horn were studied in chicken, hamster, rat and monkey spinal cords, using pap and protein a-gold double-labeling techniques in conjunction with monoclonal antibodies. in the chicken, the pap method demonstrated that sp-immunoreactive boutons contained large spherical dense-cored vesicles (dcvs) whereas 5-ht-immunoreactive boutons displayed both elongated and spherical dcvs. using the protein a ...19911715239
topographical projections from the thalamus, subthalamic nucleus and pedunculopontine tegmental nucleus to the striatum in the japanese monkey, macaca fuscata.topographical projections from the thalamus, subthalamic nucleus (stn) and pedunculopontine tegmental nucleus (ppn) to the striatum were examined in the japanese monkey (macaca fuscata) by using the retrograde axonal transport technique of wga-hrp (wheat germ agglutinin-conjugated horseradish peroxidase). after wga-hrp injection in the head of the caudate nucleus (cn) or putamen (put), labeled neuronal cell bodies in the thalamus were distributed mainly in the nucleus ventralis anterior (va)-nuc ...19901707734
distribution of neurotensin-containing fibers in the frontal cortex of the macaque monkey.the distribution of neurotensin-containing fibers was examined in the frontal cortex of the monkey macaca fuscata using the immunoperoxidase histochemical technique. an extremely dense network of neurotensin-containing fibers was observed in the medial prefrontal regions. the majority of cortical neurotensin fibers was observed in the anterior cingulate cortex (walker's area 24) and adjacent medial prefrontal regions (areas 6 and 32). in area 24, the fiber density was similar to that in the nucl ...19901698832
formant frequency discrimination by japanese macaques (macaca fuscata).these studies investigated formant frequency discrimination by japanese macaques (macaca fuscata) using an ax discrimination procedure and techniques of operant conditioning. nonhuman subjects were significantly more sensitive to increments in the center frequency of either the first (f1) or second (f2) formant of single-formant complexes than to corresponding pure-tone frequency shifts. furthermore, difference limens (dls) for multiformant signals were not significantly different than those for ...19921619126
formant frequency discrimination by japanese macaques (macaca fuscata).these studies investigated formant frequency discrimination by japanese macaques (macaca fuscata) using an ax discrimination procedure and techniques of operant conditioning. nonhuman subjects were significantly more sensitive to increments in the center frequency of either the first (f1) or second (f2) formant of single-formant complexes than to corresponding pure-tone frequency shifts. furthermore, difference limens (dls) for multiformant signals were not significantly different than those for ...19921619126
[clinical and experimental study of shortening osteotomy of forearm bone(s) in kienböck's disease].sixty-nine patients with kienböck's disease were surgically treated from 1972 to 1987. eleven patients with ulnar minus variance, 48 with neutral variance and 10 with ulnar plus variance were treated with shortening osteotomy of the radius. ten patients with ulnar plus variance were treated with shortening osteotomy of both the radius and ulna. all cases were followed up from one to eleven years. satisfactory improvement was attained in 85% of cases. radiologic evaluation showed revascularizatio ...19892738425
[clinical and experimental study of shortening osteotomy of forearm bone(s) in kienböck's disease].sixty-nine patients with kienböck's disease were surgically treated from 1972 to 1987. eleven patients with ulnar minus variance, 48 with neutral variance and 10 with ulnar plus variance were treated with shortening osteotomy of the radius. ten patients with ulnar plus variance were treated with shortening osteotomy of both the radius and ulna. all cases were followed up from one to eleven years. satisfactory improvement was attained in 85% of cases. radiologic evaluation showed revascularizatio ...19892738425
delayed response deficits produced by local injection of bicuculline into the dorsolateral prefrontal cortex in japanese macaque monkeys.bicuculline (10-30 micrograms, but usually 30 micrograms) was injected locally into 20 different sites in the dorsolateral prefrontal cortex (pfc) of 2 japanese macaque monkeys, while they were performing a delayed response task. the task was initiated by the rotation of a handle to a central zone by the wrist joint and consisted of seven periods: an initial waiting period of 0.3 s, a pre-cue period (central green lamp of 1.0 s), a cue period (left or right green cue of 0.3 s), a delay period of ...19892744104
age-related accumulation of lipofuscin in myocardium of japanese monkey (macaca fuscata).deposition of lipofuscin autofluorescent granules, is an important phenomenon in the aging process. cardiac lipofuscin in japanese monkey (macaca fuscata) first appears at approximately two years of age. thereafter, the amount of cardiac lipofuscin increases with increasing age. the first appearance of cardiac lipofuscin shows a good correlation with the maximum life span of animals. moreover, the rate of lipofuscin accumulation is inversely correlated with life span energy potential (lep) of an ...19892747299
[the blood flow in post-laminar optic nerve in monkeys was dependent on intraocular pressure level].the effects of artificial elevation of intraocular pressure on the blood flow in the 1mm post-laminar portion of the optic nerve was evaluated in 9 monkeys (macaca fuscata). the intraocular pressure of one eye was elevated while the fellow eye served as control. the intraocular pressure of the control was maintained at 15 mmhg. we used the hydrogen clearance method in quantitating the blood flow. anesthesia was maintained with injection of pentobarbital sodium into the femoral vein. in each expe ...19892773702
suppression of visually initiated hand movement by stimulation of the prefrontal cortex in the monkey.five adult monkeys (macaca fuscata) were trained for the go/no-go hand movement task with discrimination between two different color stimuli. the go stimulus was accompanied by a reward when a monkey lifted a lever by wrist extension within the stimulus duration (500 ms). whereas the no-go stimulus was not. the monkey revealed the potential specific to the no-go response in the prefrontal cortex, called 'no-go potential', i.e. surface-negative, depth-positive deflexions in the cortex of the dors ...19892776028
glutathione conjugation of nitro compounds by monkey glutathione s-transferases.the distribution in japanese monkey tissues of glutathione s-transferase activity toward some aromatic nitro compounds was examined by measuring the release of the nitro group as nitrite ion. the activity was especially high in liver, kidney and small intestine when compounds such as 4-nitroquinoline n-oxide, 5-nitrofurfural diacetal and o-dinitrobenzene were used as substrates. the nitrite-releasing activity of the major enzyme purified from rhesus monkey liver was also tested on fifty-two nitr ...19892783152
development of a series of monoclonal antibodies recognizing leukocyte differentiation antigens of japanese monkeys (macaca fuscata).six monoclonal antibodies to japanese monkey leukocytes were developed. these monoclonal antibodies, designated the u series, cover most kinds of leukocytes (pan t cells, cd8+ cells, cd8+ subset and granulocytes, cd16+ cells, monocytes/macrophages), and should be useful in the immunological analysis of primate models, such as tissue transplants and virus-related diseases, in particular, acquired immune deficiency syndrome (aids).19892785602
development of a series of monoclonal antibodies recognizing leukocyte differentiation antigens of japanese monkeys (macaca fuscata).six monoclonal antibodies to japanese monkey leukocytes were developed. these monoclonal antibodies, designated the u series, cover most kinds of leukocytes (pan t cells, cd8+ cells, cd8+ subset and granulocytes, cd16+ cells, monocytes/macrophages), and should be useful in the immunological analysis of primate models, such as tissue transplants and virus-related diseases, in particular, acquired immune deficiency syndrome (aids).19892785602
[changes in plasma estradiol, progesterone and lh level in the menstrual cycle of the adult female japanese monkey during the mating season].adult 15 female japanese monkeys showing regular menstrual cycles were subjected to the daily blood sampling for the measurement of estradiol (e2), progesterone (p) and biological lh in the mating season. monkeys were maintained under controlled conditions in a standardized environment. of the 35 cycles observed, 18 (51.4%) were estimated as anovulatory cycles and 17 (48.6%) were ovulatory cycles. the anovulatory cycles were classified into three types according to the peak level of e2 (type i: ...19892792201
[changes in plasma estradiol, progesterone and lh level in the menstrual cycle of the adult female japanese monkey during the mating season].adult 15 female japanese monkeys showing regular menstrual cycles were subjected to the daily blood sampling for the measurement of estradiol (e2), progesterone (p) and biological lh in the mating season. monkeys were maintained under controlled conditions in a standardized environment. of the 35 cycles observed, 18 (51.4%) were estimated as anovulatory cycles and 17 (48.6%) were ovulatory cycles. the anovulatory cycles were classified into three types according to the peak level of e2 (type i: ...19892792201
comparative anatomy of the accessory ciliary ganglion in mammals.the orbits of 13 mammalian species (pig, sika deer, domestic sheep, horse, cat, fox, racoon dog, marten, rat, rabbit, crab-eating macaque, japanese macaque and man) were stained with silver nitrate and dissected under a dissecting microscope with special attention to the presence and location of the accessory ciliary ganglion. some preparations were stained with thionin and examined as whole-mounts in a transmission microscope. the accessory ciliary ganglion was present in all 13 species, althou ...19892802184
inexpensive outdoor enclosure for japanese macaques used in biobehavioral research.for studies of alcohol self-administration in a monkey social group, we effectively and humanely enclosed nine japanese macaques (macaca fuscata) in an ellipse 32 x 40m, with a 1 m high chain-link fence surmounted by a 3 m curtain of electrically conductive nylon net. high-voltage brief-pulse charges prevent climbing on the net. materials for this fence cost less than $14.50 per running meter. weeds and grass grew freely within the ellipse, and seven dead trees interconnected with ropes permitte ...19892811281
comparative study of mitogenic responses in man and japanese monkeys (macaca fuscata): responses of t-cell subsets, accessory cell dependency, and interleukin-2 receptor expression.responses of peripheral blood mononuclear cells to phytohemagglutinin-p (pha-p), concanavalin-a (cona), and pokeweed mitogen (pwm) were compared in man and japanese monkeys. both cd8+ and cd8- t subsets showed greater responses to cona than to pha-p in the japanese monkey. addition of macrophages to each t subset produced more effective augmentation of cona response in the japanese monkey than in man, and cona induced more interleukin-2-receptor-positive blast cells than pha-p did in japanese mo ...19872828629
comparative study of mitogenic responses in man and japanese monkeys (macaca fuscata): responses of t-cell subsets, accessory cell dependency, and interleukin-2 receptor expression.responses of peripheral blood mononuclear cells to phytohemagglutinin-p (pha-p), concanavalin-a (cona), and pokeweed mitogen (pwm) were compared in man and japanese monkeys. both cd8+ and cd8- t subsets showed greater responses to cona than to pha-p in the japanese monkey. addition of macrophages to each t subset produced more effective augmentation of cona response in the japanese monkey than in man, and cona induced more interleukin-2-receptor-positive blast cells than pha-p did in japanese mo ...19872828629
a serological survey of simian virus 40 in monkeys.a serological survey of simian virus 40 (sv 40) was conducted by an immune adherence hemagglutination (iaha) test in breeding monkeys. of a total of 356 monkeys tested, 168 (47.2%) were seropositive. all 168 seropositive monkeys were detected from 224 monkeys which were bred or kept in japan for a long time. in contrast, none of the 132 monkeys which were newly imported from southeast asia was seropositive. if a comparison was made in the same breeding place, the positive rate of 80.4% (111/138) ...19872828892
a serological survey of simian virus 40 in monkeys.a serological survey of simian virus 40 (sv 40) was conducted by an immune adherence hemagglutination (iaha) test in breeding monkeys. of a total of 356 monkeys tested, 168 (47.2%) were seropositive. all 168 seropositive monkeys were detected from 224 monkeys which were bred or kept in japan for a long time. in contrast, none of the 132 monkeys which were newly imported from southeast asia was seropositive. if a comparison was made in the same breeding place, the positive rate of 80.4% (111/138) ...19872828892
establishment of primate lymphoblastic cell lines by coculture with a simian t-cell leukemia virus-1 positive, hypoxanthine-guanine-phosphoribosyltransferase negative japanese macaque cell line.a cell line (jamh17+) resistant to 8-azaguanine was established from a human t-cell leukemia virus type 1 related virus (simian t-cell leukemia virus-1) positive japanese macaque cell line. lymphoblastic cell lines were established from the peripheral blood mononuclear cells of humans, hominoids, and several species of macaques by coculture with jamh17+ in hypoxanthine-aminopterin-thymidine medium. htlv-1 specific antigen was detected in some of the established cell lines. phenotypic analysis sh ...19882835483
phylogenetic relationships among japanese, rhesus, formosan, and crab-eating monkeys, inferred from restriction-enzyme analysis of mitochondrial dnas.mitochondrial dna (mtdna) polymorphisms in four species of macaques, i.e., japanese monkey (macaca fuscata), rhesus monkey (m. mulatta), formosan monkey (m. cyclopis), and crab-eating monkey (m. fascicularis), were analyzed to study phylogenetic relationships. when 17 restriction enzymes of 6-bp recognition were used, 42-49 sites were observed in the samples. the estimated number of nucleotide substitutions per site among japanese, rhesus, and formosan monkeys ranges from 0.0318 to 0.0396, and t ...19882838721
the oxygen affinity of mammalian hemoglobins in the absence of 2,3-diphosphoglycerate in relation to body weight.we studied the oxygenation of mammalian hemoglobins: mouse (mus musculus molossinus), rabbit (oryctolagus cuniculus domesticus), japanese monkey (macaca fuscata), man (homo sapiens), sheep (ovis aries), llama (lama glama), pig (sus scrofa domesticus), cow (bos taurus domesticus) and horse (equus caballus), in the absence of 2,3-diphosphoglycerate (dpg) and compared their oxygen affinity in relation to the body weight. the negative correlation between body weight and the oxygen affinity of the wh ...19852866879
cloning and sequencing of rhesus monkey pepsinogen a cdna.the complete nucleotide sequence of rhesus monkey (macaca mulatta) pepsinogen a (pga) cdna was determined from two partially overlapping cdna clones, covering the whole coding sequence and part of the flanking sequences. the nucleotide and deduced amino acid sequences were compared to known pga sequences from other species. the degree of similarity with human pga appeared to be 96% at the nucleotide sequence level and 94% at the amino acid sequence level. in the coding region the divergence was ...19882900796
periodontal changes after experimentally induced intrusion of the upper incisors in macaca fuscata monkeys.we are studying the biologic aspects of vertical movement of teeth, which are often used in orthodontic treatment involving variations in alveolar tissue. in the present study, the four upper incisors of five infant macaca fuscata monkeys were intruded vertically from 1.1 to 5.5 mm. the following effects were examined: (1) movement of the gingiva, (2) change in the depth of the gingival sulcus, and (3) microscopic effects on the alveolar tissue. the results were as follows. (1) the gingiva moved ...19892916468
comparative distribution of three opioid systems in the lower brainstem of the monkey (macaca fuscata).the regional distribution of the three opioid peptide neuronal systems--proopiomelanocortin (pomc), proenkephalin a, and proenkephalin b--was investigated in the lower brainstem of japanese monkeys (macaca fuscata) by immunocytochemical techniques. antiserum to beta-endorphin/beta-lipotropin, [met]-enkephalin-arg6-gly7-leu8, and human leumorphin were used to identify the pomc and the proenkephalin a and b systems, respectively. pomc-related immunoreactive material was not found in the neuronal p ...19892918080
comparative distribution of three opioid systems in the lower brainstem of the monkey (macaca fuscata).the regional distribution of the three opioid peptide neuronal systems--proopiomelanocortin (pomc), proenkephalin a, and proenkephalin b--was investigated in the lower brainstem of japanese monkeys (macaca fuscata) by immunocytochemical techniques. antiserum to beta-endorphin/beta-lipotropin, [met]-enkephalin-arg6-gly7-leu8, and human leumorphin were used to identify the pomc and the proenkephalin a and b systems, respectively. pomc-related immunoreactive material was not found in the neuronal p ...19892918080
cortical deafness cannot account for the inability of japanese macaques to discriminate species-specific vocalizations.bilateral ablation of the superior temporal gyrus in japanese macaques results in a significant hearing loss (cortical deafness) as well as in an inability to discriminate between two types of their "coo" vocalizations. a two-part investigation was conducted to determine whether the hearing loss may itself affect the ability to discriminate vocalizations. first, four normal japanese macaques were tested for their ability to discriminate coos which were filtered to simulate the effect of a cortic ...19892920286
effect of restricted cortical lesions on absolute thresholds and aphasia-like deficits in japanese macaques.the effect of small bilateral cortical lesions on pure-tone audiograms and on the ability to discriminate between two types of japanese macaque coo vocalizations was determined in four japanese macaques (macaca fuscata). a lesion that included the middle portion of the superior temporal gyrus of both hemispheres, that is, the primary and secondary auditory areas, resulted in a partial hearing loss as well as an inability to discriminate the vocalizations. lesions that included the ventral portio ...19892923669
ontogeny of cholecystokinin-8 and glutamic acid decarboxylase in cerebral neocortex of macaque monkey.concentration of cholecystokinin-8 and the activity of glutamic acid decarboxylase were determined in the various cerebral cortical subdivisions of japanese monkey (macaca fuscata fuscata) at three different ages (embryonic 4 months, full-term and adult). the cck-8 immunoreactive material extracted with 90% methanol from the cerebral cortex of the adult and foetal monkey were shown to be identical with synthetic cholecystokinin-8 by the criterion of co-elution on gel filtration chromatography (s ...19892924846
categorical perception of conspecific communication sounds by japanese macaques, macaca fuscata.field studies indicate that japanese macaque (macaca fuscata) communication signals vary with the social situation in which they occur [s. green, "variation of vocal pattern with social situation in the japanese monkey (macaca fuscata): a field study," in primate behavior, edited by l. a. rosenblum (academic, new york, 1975), vol. 4]. a significant acoustic property of the contact calls produced by these primates is the temporal position of a frequency peak within the vocalization, that is, an i ...19892925998
complex carbohydrate histochemistry of the surface and gastric pit epitheliums of the japanese macaque. 19862947023
mucous cell types in the major and minor salivary glands of the japanese macaque. 19862947024
aspiration pneumonia with adenovirus infection in a japanese macaque (macaca fuscata fuscata).pneumonia with aspiration of foreign bodies and adenovirus infection was identified in a wild japanese macaque which died 1 month after capture. the adenovirus infection was considered to be secondary in importance to the pneumonia.19852983149
establishment of a brain-tumor model in adult monkeys.a brain-tumor model in adult monkeys may be significant because of the biological similarity to humans as well as the feasibility for surgical manipulation and for sequential computerized tomography (ct) scanning. in the present study, brain tumors were successfully produced in japanese monkeys (macaca fuscata), each weighing 2 to 10.8 kg, with an average age of 5.1 years old. tumor cells were implanted by intracerebral inoculation of 4 x 10(7) chick embryo fibroblasts infected with the schmidt- ...19852997416
establishment of a brain-tumor model in adult monkeys.a brain-tumor model in adult monkeys may be significant because of the biological similarity to humans as well as the feasibility for surgical manipulation and for sequential computerized tomography (ct) scanning. in the present study, brain tumors were successfully produced in japanese monkeys (macaca fuscata), each weighing 2 to 10.8 kg, with an average age of 5.1 years old. tumor cells were implanted by intracerebral inoculation of 4 x 10(7) chick embryo fibroblasts infected with the schmidt- ...19852997416
computed tomography of monkey brain tumors.thirty-five japanese monkeys were inoculated intracerebrally with chick embryo fibroblasts that were producing schmidt-ruppin strain of rous sarcoma virus. tumors were induced in 54.3% (19/35). computed tomography detected tumors in 10 symptomatic animals with an average latency of 32.6 (15-43) days. at autopsy, the brains were sectioned into 5 mm slices, coplanar to the ct image. various ct features of high- and low-density area correlated well with the histopathological findings, such as tumor ...19863018054
computed tomography of monkey brain tumors.thirty-five japanese monkeys were inoculated intracerebrally with chick embryo fibroblasts that were producing schmidt-ruppin strain of rous sarcoma virus. tumors were induced in 54.3% (19/35). computed tomography detected tumors in 10 symptomatic animals with an average latency of 32.6 (15-43) days. at autopsy, the brains were sectioned into 5 mm slices, coplanar to the ct image. various ct features of high- and low-density area correlated well with the histopathological findings, such as tumor ...19863018054
nucleotide sequence of the bamhi repetitive sequence, including the hindiii fundamental unit, as a possible mobile element from the japanese monkey macaca fuscata.clustered repeat units produced by bamhi digestion of genomic dna from the japanese monkey macaca fuscata [jmr(bamhi)] were sequenced by dideoxy dna sequencing. the nucleotide sequences of several individual repeats showed that the bamhi repeat contains the 170-bp hindiii element as an integral part, and that it has more than 90% homology with the hindiii repeat element [agmr(hindiii)] found in the genomic dna of the african green monkey. in the jmr(bamhi) repeat unit, the 170-bp hindiii element ...19863027353
differences of superoxide production in blood leukocytes stimulated with thymol between human and non-human primates.thymol induced superoxide production (o2-) by blood leukocytes was examined in various primates including man. leukocytes of chimpanzee and hamadryas baboon cells showed only 35% of the maximal o2- production rate obtained in human cells, and those of the japanese monkey and orang-utan failed to respond. in contrast, when cells were stimulated with 12-o-tetradecanoyl phorbol acetate, no significant difference in the o2- production rate was observed between human and monkey cells except for chimp ...19873041150
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