| delayed-onset pulmonary insufficiency in primates resuscitated from hemorrhagic shock. | forty-one unanesthetized cynomolgus monkeys were subjected to 2 hours of hemorrhagic hypotension at various mean arterial pressures (map) between 40 and 60 mm hg. resuscitation and maintenance of map were provided by lactated ringer's solution and homologous blood. thirty-eight per cent (57% of those surviving greater than 24 hours) developed a delayed-onset (18 to 24 hours) pulmonary insufficiency in spite of good urinary output, and which did not respond to furosemide. the group in which this ... | 1979 | 36483 |
| characterization of a virus isolated from a case of human infectious hepatitis. | a new viral agent, isolated from the serum of an infectious hepatitis patient and designated as agent ii-b, was extensively studied in in vitro and in vivo systems. agent ii-b multiplied well in primary and serial animal cell cultures and in embryonated hen's eggs. quantal and quantitative infectivity assays were performed in monolayers of african green monkey kidney cells. effective concentrations of 5-iodo-2-deoxyuridine and guanidine hydrochloride did not inhibit the multiplication of agent i ... | 1979 | 36750 |
| a summary of the results of a drug self-administration study using substitution procedures in rhesus monkeys. | | 1978 | 36945 |
| regional distribution of monoamines in the cerebral cortex and subcortical structures of the rhesus monkey: concentrations and in vivo synthesis rates. | endogenous monoamine concentrations and turnover rates vary markedly in different regions of neocortex as well as in various subcortical structures of young adult rhesus monkeys. monoamine levels and synthesis rates in amygdala, hippocampus, neostriatum, thalamus and brain stem are generally similar to comparable measures previously reported in a variety of species. however, extending and confirming the results of an earlier study, cortical monoamines exhibit topographically specific patterns of ... | 1979 | 36962 |
| subcellular distribution and properties of intestinal histamine-metabolizing enzymes from rats, guinea pigs and rhesus monkeys. | | 1979 | 37037 |
| the protection of primates against soman poisoning by pretreatment with pyridostigmine. | the effectiveness of pyridostigmine pretreatment against soman poisoning has been determined in rhesus monkeys and marmosets receiving atropine therapy. pretreatment with the maximum sign-free dose (200 microgram kg-1, i.v.) raised the subcutaneous ld50 of soman by a factor of 28 in rhesus monkeys and 15 in marmosets. the protection afforded by a quarter of the sign-free dose of pyridostigmine was not significantly less. these levels of protection are higher than any reported in non-primate spec ... | 1979 | 37298 |
| pharmacological studies on 3-]gamma-(p-fluorobenzoyl)propyl]-2,3,4,4a,5,6-hexahydro-1-(h)-pyrazino ]1,2-a] quinoline hydrochloride (compound 69/183). part iii: assessment of tranquillising activity. | the tranquillising activity of 3-[gamma-(p-fluorobenzoyl)propyl]-2,3,4,4a,5,6-hexahydro-1-(h)-pyrazino [1, 2-a]quinoline hydrochloride (centpyraquin), a new adrenergic neurone blocking antihypertensive agent, has been evaluated in various laboratory animals. the compound has a calming effect in mice, rats, cats and monkeys. in low doses it reduces the spontaneous motor activity followed in progressively higher doses by hypothermia, ptosis and catalepsy and a taming effect in monkeys and cats. it ... | 1978 | 37855 |
| disposition of flunisolide in the rat, mouse, dog, rhesus monkey, and cynomolgus monkey. | flunisolide (6 alpha-fluoro-11 beta, 16 alpha, 17 alpha, 21-tetrahydroxypregna-1,4-diene-3,20-dione 16,17-acetonide) administered as a single iv or oral dose to rats, mice, dogs, rhesus monkeys, and cynomolgus monkeys had a plasma t 1/2 of 1-3.5 hr and was eliminated mainly via the bile. after iv administration of 14c-labeled flunisolide, radioactivity was widely distributed into tissues and organs. the apparent volume of distribution of flunisolide in these five species was 3.0-8.0 liters/kg. a ... | 1979 | 38078 |
| meyenburg complexes of the liver and bile cysts as a consequence of hepatic ischemia. | meyenburg complexes and simple bile cysts are described in a patient having polyarteritis nodosa with involvement of the intrahepatic arterial tree. similar lesions are found in the liver of monkeys subjected to experimental occlusion of the peripheral hepatic arterial tree. it is proposed that a pathogenetic mechanism conducive to the formation of meyenburg complexes may be hepatic ischemia. | 1979 | 38201 |
| the effect of histamine-1 and histamine-2 antagonists on airway responses to histamine in the rhesus monkey. | this study used rhesus monkeys with consistent respiratory responses to aerosolized histamine. two systems of histamine challenge were evolved to study the effects of histamine antagonists on the histamine-induced respiratory response. one system consisted of administering increasing subreactive concentrations of histamine until an airway response (h) occurred. this threshold histamine dose was repeated (h'). the pulmonary function changes occurring with the h' challenge were less intense than t ... | 1979 | 38270 |
| fucntional specialization and binocular interaction in the visual areas of rhesus monkey prestriate cortex. | if is is believed that neural mechanisms mediating stereoscopic vision may be localized in specific areas of the visual cortex, then it becomes necessary to be able to define these areas adequately. this is no easy matter in the rhesus monkey, an animal close to man, where the cytoarchitecturally uniform prestriate cortex is folded into deep sulci with secondary gyri. one way around this awkward problem is to use the callosal connections of the prestriate cortex as the anatomical landmarks. call ... | 1979 | 38453 |
| brain damage and global stereopsis. | when a single object lies in front of or beyond the plane of fixation its retinal image lies on disparate positions in the two eyes. this 'local' retinal disparity is an excellent cue to depth, and retinal disparties of a few seconds of arc are detectable by people and monkeys. however, most visual scenes produce a complex array of contours in each eye and we can detect the disparity in the arrays despite the ambiguous nature of the disparities, i.e. each contour in one eye could be related to a ... | 1979 | 38454 |
| depth sensitivity of binocular cortical neurons of behaving monkeys. | activity of neurons if foveal striate and prestriate cortex of trained rhesus monkeys was recorded with metal microelectrodes. while animals fixated a small spot at a given fixation distance (38 or 57 cm), bright or dark bars moving across a frontoparallel plane were presented at different depths in a range of +/- 10 cm about the fixation distance. almost all cells showed binocular interaction. neurons with balanced ocularity (approximately equal monocular responses) usually facilitated each oth ... | 1979 | 38455 |
| breathing movements before death in the primate fetus (macaca mulatta). | the incidence and character of fetal breathing movements (fbms) were determined by analysis of continuous tracheal pressure recordings in a 48 hour period preceeding fetal death in utero in 7 chronic pregnant monkey preparations (macaca mulatta). all fetuses were judged normal by blood gas tensions, ph, and fetal heart rate within 48 hours of death. in the normal fetus breathing movements were periodic and a circadian distribution in the incidence of fbms was observed. four distinct patterns of ... | 1979 | 38667 |
| mechanical properties and functions of the myoepithelium in the eccrine sweat gland. | contractile properties of an isolated segment of the secretory coil of the monkey palm eccrine sweat gland were studied in vitro with a transducer. contraction of up to 10 mgf was induced with acetylcholine but not with alpha or beta adrenergic agonists, caffeine, prostaglandin e1, or by a calcium ionophore a23187. other features included k+ contracture, staircase effect, poor extensibility, length-tension relationship with a peak tensile response at 115--120% of the resting length, and requirem ... | 1979 | 38671 |
| intracellular redox states under halothane and barbiturate anesthesia in normal, ischemic, and anoxic monkey brain. | cortical reflectance, mean arterial blood pressuees, electroencephalograms, and cortical blood flow were continuously recorded together with fluorescence of reduced pyridine nucleotides (pn) at various carbon dioxide tensions before, during, and following middle cerebral artery occlusion in 10 squirrel monkeys receiving halothane or babiturate anesthesia. measurements were continued through a nitrogen breathing cycle and to death produced by anoxia. the anesthetic agent produced no detectable di ... | 1979 | 38737 |
| stereochemistry of viminol, a novel central analgesic. | the synthesis of the stereoisomers of the centrally acting analgesic 1-[1-(2-chlorobenzyl)-pyrrol-2-yl]-2-di-sec.-butylamino-ethanol (viminol) is described. their absolute configuration has been shown by comparing the circular dichroism (cd) curves with those of some phenyl analogs: for one of the viminol stereoisomers the postulated configurational assignment has been recently confirmed by an x-ray analysis. the pharmacological properties shared by the viminol stereoisomers are also described. ... | 1978 | 38816 |
| a monitoring test for the liability of neuroleptic drugs to induce tardive dyskinesia. | two cebus apella monkeys with haloperidol-induced tardive dyskinesia have been studied. substitution of chlorpromazine, thioridazine, clozapine, melperone, or fluphenazine for the daily haloperidol administration temporarily reduced the signs of tardive dyskinesia. in a monkey with low-grade symptoms, persisting for more than 100 days after withdrawal of haloperidol, neuroleptic drugs induced a typical sequence of events: first the dyskinetic movements were abolished, but 1--3 days after adminis ... | 1979 | 39307 |
| anaphylaxis in the monkey: respiratory mechanics, acid-base status and blood gases. | aggregate anaphylaxis was induced by intravenous injection of the specific antigen in eight ovalbumin-sensitized monkeys. changes in respiratory mechanics, acid-base status and blood gases were studied during the following half hour. within 1 minute after challenge, a short period of respiratory depression, probably reflex-mediated, was observed. this was followed by hyperventilation, and arterial pco2 decreased. there was a rapid increase in pulmonary resistance (rpulm) and a concomitant decrea ... | 1979 | 39417 |
| cardiovascular profile of 2-(3,4-diethyoxy-beta-methoxyphenethyl) imino-1-methylpyrrolidine fumarate (mcn-2840-46), a preferential atrial anti-arrhythmic agent. | mcn-2840-46, 2.5 mg/kg, i.v., protected against atrial tachyarrhythmias induced by three different methods in dogs and monkeys. the compound was inactive against ventricular arrhythmias produced by ouabain and by chloroform-epinephrine interaction at a four-fold higher dose. significant reversal of ventricular arrhythmias produced by occlusion of the left anterior descending coronary artery in dogs was achieved by infusion of 8.8 +/- 2.4 mg/kg, i.v. of mcn-2840-46. myocardial electrogram studies ... | 1979 | 39528 |
| [clinical and immunological studies on acquired heat contact urticaria (author's transl)]. | a case of localized urticaria in an otherwise healthy young woman, produced only by direct contact of the skin with heat, is described. the minimal temperature of urtication was 44 degrees c (immersion of the forearm in hot water for 5 min). redness and painful oedema immediately developed without reflex flare. total serum igg, iga, igm, ige, complement factors c3 and c4, and alpha1-antitrypsin were in the normal range, whereas the c1-inhibitor level was slightly decreased. there was no evidence ... | 1979 | 39803 |
| some properties of brain specific benzodiazepine receptors: new evidence for multiple receptors. | several new lines of evidence suggest the existence of two or more distinct types of benzodiazepine receptors, in contrast to earlier results suggesting the presence of only one class of receptors. appropriate thermoinactivation experiments indicate two receptors with different thermostabilities. several triazolopyridazines, with some of the pharmacological properties of anxiolytics have recently been shown to displace 3h-diazepam and 3h-flunitrazepam with ki values in the 6 to 100 nanomolar ran ... | 1979 | 40257 |
| metabolism of 8-chloro-6-(o-chlorophenyl)-1-methyl-4h-s-triazolo [4,3-alpha] [1,4] benzodiazepine, triazolam, a new central depressant. i. absorption, distribution and excretion in rats, dogs and monkeys. | 1. peak radioactivity in the blood was reached at 30 min after i.p. and 1 h after oral dosing of [14c]triazolam to rats. in dogs, peak blood level was observed at 30 min after oral dosing. 2. daily dosing of triazolam to male rats for 21 days caused a gradual increase in blood level, with peak at 1 h after dosing. 3. the rate of binding of triazolam plus its metabolites to plasma protein of rats was about 30% at 15 min and 6 h. 4. in rats, the majority of the activity of the intra-intestinally a ... | 1979 | 40350 |
| effect of indomethacin on prostaglandin and steroid synthesis by the marmoset ovary in vivo. | indomethacin decreased prostaglandin f 2 alpha levels in the ovaries of marmoset monkeys which were treated with pms/hcg. the production of estradiol and progesterone, however, was unaffected by the blockade in prostaglandin synthesis. the number of ovulations following pms/hcg treatment was significantly reduced by indomethacin treatment. these observations suggest that prostaglandins are required for follicular rupture but not for progesterone and estradiol production by the ovary. | 1979 | 40910 |
| effect of macular ablation on vertical optokinetic nystagmus in the squirrel monkey. | after macular ablation in squirrel monkeys, a significant improvement of the slow-phase eye speed of vertical optokinetic nystagmus (vokn) was found. this findings is in contrast to the result of our previous study in which horizontal optokinetic nystagmus (hokn) was not improved following macular ablation. the different influence of macular ablation on hokn and vokn could be due to the directional characteristics of vestibular and visual interaction relative to the direction of gravity and to t ... | 1979 | 41202 |
| the effect of oral pancreatic extract on jejunal bactericidal activity in protein-deficient vervet monkeys challenged with vibrio cholerae. | eleven vervet monkeys (cercopithecus aethiops) were fed with an "o" protein diet. after the serum albumin level fell below 2.5 g/100 ml the animals and 4 controls, which received regular monkey chow, were orally infected with a monkey-adapted strain of vibrio cholerae. the total bactericidal activity of the jejunal fluid decreased during feeding with "o" protein diet, but increased after challenge with v. cholerae in all groups. the non-immunoglobulin-bound bactericidal activity, which also decr ... | 1979 | 41422 |
| jos virus infection in domestic animals and primates. pathogenicity and immunological studies. | three species of domestic animals (rabbits, sheep and goats) and two species of primates erythrocebus patas monkeys and baboon (papio anubis) were infected with jos virus. none of the infected animals developed viraemia or overt clinical disease. complement-fixing and neutralising antibodies were demonstrated in sera of infected animals. | 1979 | 41441 |
| pharmacokinetics of closely related benzodiazepines. | 1 it is commonplace for drugs to vary by only minor chemical differences. this is particularly so for those seven benzodiazepines discussed in this paper which are related both as precursors and as metabolites. however, minor chemical differences may cause major differences in physicochemical and pharmacodynamic properties. 2 although the physicochemical differences are difficult to relate to effect, the influence of structure on absorption, distribution and elimination is of considerable import ... | 1979 | 41538 |
| morphological characterisitcs of the pathological process in the central nervous system of monkeys infected with variants of measles virus strain l-16. | the neurovirulence of l-16 vaccine measles virus strains and its 9 clonal variants was investigated in intracerebrally infected macaca mulatta monkeys. two groups of clones were distinguished: one comprised variants that caused destructive changes of neurons in the brain and diffuse proliferative gliosis, and the second variants that caused changes of a transitory character, connected with the traumatic exposure. | 1979 | 42298 |
| international forum update: depot medroxyprogesterone acetate and endometrial carcinoma. | in response to a recent report (fam plann perspect 11: 47, 1979) that two of 12 rhesus monkeys given 50 times the human dose of depot medroxyprogesterone acetate (dmpa), by body weight, for ten years had developed endometrial carcinoma (ca), a retrospective survey of all hospital admissions for proven endometrial ca in two thai provinces where dmpa contraceptive injections have been widely used since 1965 was made. from 1974 through 1978, 16 women were hospitalized with confirmed diagnoses of en ... | 1979 | 42591 |
| a neutral proteinase of monkey liver microsomes. solubilization, partial purification, and properties. | conditions for the solubilization of membrane-bound neutral proteinase associated with monkey liver microsomes were investigated. among the reagents tested, deoxycholate, cholate, and some nonionic detergents, including triton x-100, with hydrophilic-lipophilic balance values of around 13, were effective. the solubilization profile indicated that the enzyme is bound to the microsomal membranes by strong hydrophobic interaction. the enzyme was partially purified from monkey liver microsomal fract ... | 1979 | 42645 |
| oncofoetal antigens of human trophoblast. | rabbits immunized with human trophoblast cell membranes produced antibodies that were detected, by immunofluorescence, to react with normal human tissues, and, by complement-mediated cytotoxicity, with several transformed human cell lines. absorption with trophoblast abolished all of these reactions, whereas multiple absorptions with lymphocytes, liver or kidney failed to remove reactivity with either trophoblast or certain transformed cells. to further identify the antigens responsible for thes ... | 1979 | 42921 |
| comparative bioavailability and pharmacokinetic studies of azathioprine and 6-mercaptopurine in the rhesus monkey. | azathioprine (aza) is cleaved in vivo by glutathione to 6-mercpatopurine (6-mp). 6-mp plasma levels were measured by hplc in four male rhesus monkeys following oral and iv doses of the two drugs. following iv 6-mp administration, 6-mp levels were described by a two-compartment body model; mean terminal half-life; plasma clearance (clp), and volume of distribution (vdss) were 41.6 +/- 12.1 min, 48.4 +/- 15.4 ml/min/kg, and 1.76 +/- 0.64 liters/kg, respectively. 8-hydroxymercpatopurine (8-ohmp) wa ... | 1979 | 43222 |
| determination of the anti-allergenic agent, 2-methoxy-11-oxo-11h-pyrido[2,1-b]quinazoline-8-carboxylic acid, in biological fluids by high-performance liquid chromatography. | a rapid, sensitive, and specific high performance liquid chromatographic (hplc) assay was developed for the determination of 2-methoxy-11-oxo-11h-pyrido-[2,1-b]quinazoline-8-carboxylic acid (i) from biological fluids. the overall recovery from blood and plasma is 69 +/- 10% (s.d.) and 84 +/- 6% (s.d.), respectively, and the sensitivity limit of quantitation is 100 ng/ml by uv absorption and 5 ng/ml by fluorescence detection using a 1 ml specimen. the assay was used in the determination of blood ... | 1979 | 44301 |
| comparative studies on dihydrofolate reductases from plasmodium falciparum and aotus trivirgatus. | dihydrofolate reductase (e.c. 1.5.1.3) from plasmodium falciparum and from its host, the owl monkey (aotus trivirgatus), were partially purified and characterized. the molecular weight of the parasite enzyme was estimated to be over 10 times as high as that of the host enzyme. the host enzyme had 2 ph optima whereas the parasite enzyme only one. the activity of the host enzyme was greatly stimulated by kcl and urea, while that of the parasite enzyme was inhibited at high concentrations of such c ... | 1979 | 44526 |
| interactions of pharmacological agents which alter biogenic amine metabolism and depression--an analysis of contributing factors within a primate model of depression. | the observation that the biogenic amine depleting agent, reserpine, could induce severe depression in a small proportion of the patients treated with it has proved to be seminal finding in what is now a much larger field of research relating the function brain biogenic amine systems to emotions and behavior. a review of the human reserpine literature suggests, however, that factors other than pharmacologically produced alterations in brain biogenic amine metabolism must have been critical determ ... | 1979 | 45183 |
| glutamine synthetase in kidneys of monkey and man. | 1. the synthesis of gamma-glutamylhydroxamate from glutamate and hydroxylamine has been utilized as an approximation of glutamine synthetase activity in kidneys of rabbit, rat, dog, monkey and man. 2. kidneys of rabbit contain glutamine synthetase in high activity; those of rat, in intermediate activity; and those of dog, monkey and man, in negligible activity. 3. no more enzyme is present in kidneys of the latter two species than in those of the dog, in which the enzyme is generally considered ... | 1978 | 45541 |
| composition of glycoproteins secreted by tracheal explants from various animal species. | 1. the acidic and neutral glycoproteins secreted by cultured tracheal explants from pigs, sheep, rats, mice, monkeys, guinea pigs, dogs and chickens were purified and fractionated by column chromatography on deae-cellulose and by electrophoresis on cellulose acetate. 2. the ratios of acidic to neutral mucus glycoproteins were compared for the above animals with that of mucus glycoproteins secreted by cultured human bronchi. 3. the observed ratios of acidic to neutral glycoproteins ranged from 4. ... | 1979 | 45551 |
| azidomorphines: a new family of potent analgesics with low dependence capacity. | 1. structure-activity relationship studies with new semi-synthetic isomorphine derivatives revealed that substitution of an azido group in position 6 (azidomorphines) greatly increases the analgesic potency whereas tolerance and dependence liability tend to decrease. 2. azidomorphine (6-deoxy-6-azidodihydroisomorphine) and 14-hydroxyazidomorphine (6-deoxy-6-azidodihydro-14-hydroxyisomorphine) being in animal tests 40-300 times more potent than morphine, are the most effective analgesics among th ... | 1979 | 45567 |
| localization of immunoreactive androgen in testicular tissue. | immunohistochemical localization of androgen in the testes of both rat and squirrel monkey has been performed using an antiserum specific to testosterone and certain related androgens. the bound antibodies were visualized by coupling with antigammaglobulin labeled either with fluorescein isothiocyanate or with a horseradish peroxidase-diaminobenzidine technique. the highest concentration of androgen was found in the interstitial tissue but a significant amount was also present in the seminiferou ... | 1975 | 45910 |
| intraepithelial lymphocytes in the male reproductive tract of rats and rhesus monkeys. | although lymphocytes are never present in 'normal ' seminiferous epithelium, they are found in the terminal portions of the seminiferous tubles near their junctions with the tubuli recti. intraepithelia lymphocytes are also found in the tubuli recti testis, ductuli efferentes, epididymis and ductus deferens. the ultrastructural morphology of these cells closely resembles that of the intraepithelial lymphocytes in the intestinal mucosa and those obtained from the lymph nodes, spleen blood and tho ... | 1975 | 45940 |
| cortico-striatal evoked potentials in the monkey (macaca mulatta). | a systematic study has been made of topographic organization in the striatum of evoked potentials elicited by stimulation of the cerebral cortex in unanesthetized, comatose monkeys (macaca mulatta). stimulation of the dorsal field of the prefrontal convexity elicited potentials primarily in rostral portions of the caudate, while stimulation of the ventral field of the prefrontal convexity elicited potentials in ventromedial areas of the putamen. stimulation of different points on the precentral ... | 1975 | 45942 |
| type c rna tumor virus isolated from cultured human acute myelogenous leukemia cells. | previously, type c rna tumor virus-related components have been described in blood leukocytes from patients with acute myelogenous leukemia. these components, for example, reverse transcriptase, have been shown to be most closely related to those from two oncogenic subhuman primate type c viruses (woolly monkey sarcoma virus and gibbon ape leukemia virus). now, we report the continuous production of budding type c viruses with the same characteristic reverse transcriptase by three separate cultu ... | 1975 | 46123 |
| slow axonal protein transport and visual function following retinal and optic nerve ischemia. | retinal ganglion cell protein synthesis and slow axonal protein flow have been measured in eight optic nerves from four macacus rhesus monkeys after producing ganglion cell ischemia. comparison of the slow axonal protein flowing into the two optic nerves of the same control animal reveals a variability of up to 27 per cent. following central retinal artery ligation, infarction of the retinal ganglion cells was reflected by a 97 per cent reduction in the radioactively labeled protein within the o ... | 1975 | 46218 |
| serological analysis of human deoxyribonucleic acid polymerases. preparation and properties of antiserum to deoxyribonucleic acid polymerase i from human lymphoid cells. | the preparation and properties of an antiserum to human dna polymerase i (6 to 8 s) are described. care was taken in the purification of the antigen to remove certain other dna polymerases found in human cells. an incubation of antigen and antiserum lasting about 48 hours is necessary to achieve maximal inhibition. about 1 mug of the antipolymerase immunoglobulin g, prepared in rats, neutralizes 60% of the activity present in 54 ng of the enzyme. tritrations varying both antiserum and enzyme dem ... | 1975 | 46229 |
| allergic encephalomyelitis. isolation of an encephalitogenic peptide active in the monkey. | a 17-residue peptide (peptide y) was isolated from the cooh-terminal end of the basic protein of bovine myelin by peptic digestion. this peptide induced experimental allergic encephalomyelitis in the rhesus monkey. treatment of peptide y with cyanogen bromide released three amino acids from the cooh-terminal end and resulted in a tetradecapeptide (peptide m) which was also encephalitogenic in the rhesus monkey. the sequence of peptide m is: phe-lys-leu-gly-gly-arg-asp-ser-arg-ser-gly-ser-pro-met ... | 1975 | 46230 |
| the antigenicity of myelin encephalitogenic protein: production of antibodies to encephalitogenic protein with deoxyribonucleic acid--encephalitogenic protein complexes. | rabbits immunized with monkey encephalitogenic protein (ep) complexed to deoxyribonucleic acid (dna) formed complement-fixing antibodies that reacted well with ep from monkey, bovine, and human brain and the large ep of rat brain. reactivity with the small ep of rat brain was much less. the antibodies, analyzed by the quantitative micro-complement fixation test, were of the 7s class, were produced in high titer, and failed to react with histone, lysozyme, or acidic liver extracts. immunohistoche ... | 1975 | 46251 |
| antigenic characterization of type c rna virus isolates of gibbon apes. | type c rna viruses initially isolated from a lymphosarcoma of a gibbon ape and from a fibrosarcoma of a woolly monkey are very closely related immunologically. however, recent studies have shown that these viruses are distinguishable in a radioimmunoassay for the 12,000-molecular-weight polypeptide (p12) of the woolly monkey virus. in the present report, an immunoassay has been developed for the p12 polypeptide of the gibbon ape type c virus. this assay is shown to further distinguish the woolly ... | 1975 | 46280 |
| microanalytical system for determination of picogram quantities of metals in metalloenzymes, as illustrated with zinc-containing enzymes. | microwave-induced emission spectrometry combined with gel-exclusion chromatography provides a microanalytical system capable of precisely measuring 10 minus 10 to 10 minus 13 g of metal in microgram amounts of enzyme. such sensitivity greatly exceeds that of other, more conventional methods. metal quenching agents and low-molecular-weight protein contaminants were removed from the enzyme by sephadex g-100 chromatography in microbore columns (0.03 times 25 cm). droplet fractions were analyzed ... | 1975 | 46797 |
| time course of development of supersensitivity to topical acetylcholine in partially isolated cortex. | in alert monkeys the time course for development of supersensitivity to topical acetylcholine in partially isolated frontal cerebral cortex was determined. thresholds for paroxysmal discharge fell progressively and markedly during 3 weeks, further in 5 and somewhat more after 6 months. ach supersensitivity was demonstrated in chronic "isolated" occipital cortex. epileptiform discharges were recorded selectively from chronic partially isolated frontal cortex on peripheral nerve stimulation and th ... | 1975 | 46800 |
| cholinergic mechanisms involved in cortical activation during arousal. | spontaneous and evoked cortical electrical activity of the post-central gyrus was studied in 5 unparalyzed, unanesthetized monkeys during slow-wave sleep (sws) and wakefulness (w), before and after the administration of a muscarinic anticholinergic agents, hyoscine. it was found that hyoscine reproduces the effect of sws: (1) on spontaneous eeg activity and single unit discharges of the somatosensory cortes without any concomitant behavioral sleep; and (2) on surface evoked potentials and reacti ... | 1975 | 46804 |
| cortical seizures following cerebellar stimulation in primates. | the effects of cerebellar stimulation were studied in monkeys with chronic alumina-cream epileptogenic foci in motor cortex. low-frequency stimulation (5-15 c/sec) was ineffective in altering spontaneous cortical spiking. clinical and electrographic seizures were elicited following high-frequency cerebellar stimulation (100 c/sec). this was a consistent finding following cerebellar stimulation, although no spontaneous seizures had been seen in these animals. these studies suggest the existence o ... | 1975 | 46822 |
| effects of repeated oral doses of demethylchlortetracycline on bones and dentin of young rhesus monkeys. | seven oral doses of demethylchlortetracycline were administered to monkeys that received serial injections of lead acetate to intravitally stain calcification sites. bone growth was greatly inhibited, whereas dentin apposition was spared from the cumulative toxicity of demethylchlortetracycline. cessation of bone growth and its duration could be correlated with serum levels. | 1975 | 46870 |
| minocycline and its influence on calcifying tissues of young monkeys. | | 1975 | 46871 |
| hazards from simian herpes viruses: reactivation of skin lesions with virus shedding. | a new simian herpes virus with biological properties similar to herpes simplex and to simian "b" virus has been used as a model system for studying virus latency in dorsal root spinal sensory ganglia. following intradermal injection, virus is present in the skin lesions and corresponding ganglia only, during the acute stage of the disease. by organ-culture techniques, latent virus was rescued from ganglia up to 2 years later. no latent virus was ever found in skin organ cultures of the primar ... | 1975 | 47078 |
| neural antigens and induction of myelination inhibition factor. | rabbits were sensitized or immunized with a variety of central nervous system antigens, including bovine spinal cord, bovine, monkey, human, guinea pig, rabbit and rat s myelin basic proteins, and a polypeptide derived from guinea pig basic protein. the animals were observed for development of experimental allergic encephalomyelitis, and their sera were collected at varying intervals after inoculation and evaluated for presence of precipitating anti-basic protein antibody and for their ability t ... | 1975 | 47359 |
| massive polyclonal hyperimmunoglobulinemia e, eosinophilia and increased ige-bearing lymphocytes. | a patient (e.m.) with marked eosinophilia and hyperimmunoglobulin e (ige) has been followed for 4 years. peripheral blood eosinophilia reached levels in excess of 18,000 cells/mm3 and serum ige concentration increased to more than 210,000 units/ml (about 0.48 mg ige/ml). the ige has both lambda and kappa light chains and is therefore considered polyclonal. the patient has an increase in peripheral blood lymphocytes which stain for surface ige. transfer of the patient's plasma (plasmsem) to a rhe ... | 1975 | 47711 |
| alterations in the upper facial growth of macaca mulatta resulting from high-pull headgear. | four prepubertal macaca mulatta monkeys, ranging in age from 13 to 24 months, were used in an investigation of the effects of high-pull headgear (to a face-bow) therapy on the growth of the upper facial skeleton. amalgam bone implants were placed across the frontomaxillary, frontozygomatic, zygomaticomaxillary, and zygomaticotemporal sutures in each animal. three of the monkeys wore appliances consisting of a maxillary dental spling, a face-bow, two coil springs, and an acrylic helmet. the fourt ... | 1975 | 47715 |
| the effects of various fixative-buffer combinations on lung fine structure. | a variety of fixatives, buffers and fixation procedures were compared in rat and squirrel monkey lung in an attempt to preserve optimally both the cytologic details of pulmonary parenchyma as well as the acellular avelolar lining layer. in initial experiments utilizing the fixative of ito and karnovsky ('68), an electron-dense deposit was observed on the alveolar surface. experiments were carried out in an attempt to determine what component of this fixative was responsible for the reaction prod ... | 1975 | 47721 |
| testis antigens of man and some other primates. | rabbit antisera raised aginst testis preparations of human, chimpanzee, rhesus monkey, and baboon origin were used to study testis-specific antigens within and among the four primate species. antisera were absorbed with serum, liver, kidney, and spleen preparations of the respective species against which they had been produced. immunoelectrophoretic analysis of testis extracts, using the absorbed antisera, indicated the following minimum numbers of testis-specific antigens for each species: man, ... | 1975 | 47818 |
| myxoviruses. | myxoviruses can be divided into 2 groups, orthomyxoviruses and paramyxoviruses. the former comprise the influenza group which is subdivided into types a,b and c. influenza b and c are purely human pathogens but influenza a, which includes a large number of antigenic subtypes, occurs in nature in pigs, horses, birds and man. all influenza a viruses irrespective of origin are chemically, biologically and genetically related. the epidemics which they cause are curious and puzzling and are an import ... | 1975 | 47825 |
| properdin factor b and histocompatibility loci linked in the rhesus monkey. | | 1975 | 48198 |
| rna-directed dna polymerase from human leukemic blood cells and from primate type-c virus-producing cells: high- and low-molecular-weight forms with variant biochemical and immunological properties. | rna-directed dna polymerase (reverse transcriptase) from leukocytes of individual leukemic patients can be grouped by velocity gradient analyses into two distinct classes, a low-molecular-weight (lmw) class of approximately 70,000 and a high-molecular-weight (hmw) class of 130,000 to 140,000. the reverse transcriptases from mammalian type-c viruses have with one exception (see text) been isolated as enzymes with molecular weights of 70,000. in this study, the reverse transcriptase from extracell ... | 1975 | 48250 |
| locus ceruleus in rhesus monkey (macaca mulatta): a combined histochemical fluorescence, nissl and silver study. | the locus ceruleus (lc) of the rhesus monkey (macaca mulatta) was investigated using the histochemical fluorescence method and nissl and ammoniacal silver stains. caudally, a few fluorescent cells were observed in the lateral wall of the ventriculus quartus near the velum medullaris superior. rostrally, the fluorescent cells were compactly clustered and reached their greatest density medial and, to a lesser extent, lateral to the tractus mesencephalicus n. trigemini at the level of the decussati ... | 1975 | 48520 |
| breakage of tolerance to alpha foetoprotein in monkeys. | | 1975 | 49026 |
| group-specific component (gc) proteins bind vitamin d and 25-hydroxyvitamin d. | group-specific component (gc) proteins are human plasma proteins for which a worldwide polymorphism exists. as yet no functional role has been assigned this protein. we show that the products of both gc alleles, proteins gc 1 and gc 2 (distinguished electrophoretically), bind substantial quantities of vitamin d and 25-hydroxyvitamin d. three lines of evidence are reported: (1) polyacrylamide gel electrophoresis and autoradiography of serum labeled with (14-c)vitamin d3 revealed patterns of radio ... | 1975 | 49052 |
| isolation from the asian mouse mus caroli of an endogenous type c virus related to infectious primate type c viruses. | treatment of a cell line derived from the asian feral mouse mus caroli with 5-bromodeoxyuridine induces an infectious, xentropic type c virus. this virus shares strongly cross-reactive reverse transcriptase (rna-dependent dna polymerase) and p30 antigens and crossinterferes with type c viruses isolated from a woolly monkey (ssav) and gibbon apes (galv). by similar criteria, the caroli virus is much less related to previously described type c viruses of the laboratory mouse, mus musculus. inducti ... | 1975 | 49058 |
| multiple specificities of mammalian blood group substances comparatively studied with human isoagglutinins and fractionated anti-h lectins. | purified blood group-active substances derived from different pig, horse, baboon, rhesus monkey and human tissues were quantitatively studied for their haemagglutination inhibiting potency with: (1) human igm anti-a and anti-b; (2) human anti-lea and anti-leb; (3) ulex europaeus extracts separated into lectin fractions with respective l-fucose-inhibitable ('anti-hf') and chitobiose-cellobiose-inhibitable ('anti-hc') combining sites. irrespective of species origin, a and b blood group activity pe ... | 1975 | 49294 |
| competition radioimmunoassay for mason-pfizer monkey virus: comparison with recent isolates. | the major core protein of mason-pfizer monkey virus was purified by deae ion exchange column chromatography and shown to be 27,000 daltons (p27). following the characterization of monospecific antisera prepared against p27, a radioimmunoassay was developed with these reagents and competition experiments were done with come of the recent m-pmy-like isolates as well as with other oncornaviruses. results suggest that three of the viruses tested, ao, x-381 and ftp-1, are similar to m-pmv while j-96 ... | 1975 | 49328 |
| demonstration of acid mucopolysaccharides in the trabecular meshwork of the rhesus monkey. | the ability to demonstrate amps in the trabecular region in the normal eye of the rhesus monkey was shown to be critically dependent upon technical variation. staining the fixed specimen prior to dehydration and embedding permits the uniform demonstration of amps in the trabecular region of the rhesus monkey and shows it to be hyaluronidase-sensitive. electron microscopy using the modified technique shows the reaction products to be present within the trabecular band, the intertrabecular spaces, ... | 1975 | 49331 |
| no evidence for particles encapsulating rna-instructed dna polymerase and high molecular weight virus-related rna in herpesvirus induced tumours of non-human primates. | the simultaneous detection test gave no evidence for the presence of rna tumour viruses in herpesvirus induced malignant lymphomas of non-human primates. the 12 tumours tested were obtained from three different monkey species inoculated with herpesvirus saimiri or herpesvirus ateles. particles encapsulating rna-instructed dna polymerase and high mol. wt. virus-related rna were easily demonstrated in tumours of the mouse induced by type-c or type-b oncornaviruses and in human lymphoid cells infec ... | 1975 | 49397 |
| structural proteins of mammalian rna tumor viruses: relatedness of the interspecies antigenic determinants of the major internal protein. | the relatedness of antigenic determinants of purified major core proteins of the murine, feline, rd 114/baboon, and woolly monkey/gibbon ape groups of rna tumor viruses was examined by competition radioimmunoassay. in assay systems of a homologous antigen and antiserum, high affinity competition for binding to all of the antibodies was observed only with the homologous unlabeled protein; the core proteins of other groups of viruses showed only low affinity binding of a small fraction of antibodi ... | 1975 | 49439 |
| a simple staining method for vaginal smears using red ink. | in adult rhesus monkeys each phase of 37 menstrual cycles was accurately classified by cellular identification of vaginal smears stained with red ink. this technic was simple, quick, and inexpensive, and produced well-stained slides in a few seconds. | 1975 | 49454 |
| the denervated meissner corpuscle. a sequential histological study after nerve division in the rhesus monkey. | the effects of denervation upon the meissner corpuscle were evaluated by sequential fingertip biopsies in 3 rhesus monkeys, following transection of all the sensory innervation of the hand. histological techniques were used to identify changes in the neural, connective, and enzymatic components of the meissner corpuscles. denervation of the meissner corpuscle resulted in rapid and complete degeneration of the axon terminal and a slowly progressive degeneration of the connective tissue component ... | 1975 | 49903 |
| a pattern in the development of agglutinogenic antigens of cyclically transmitted isolates of trypanosoma gambiense. | three isolates of t. gambiense, belonging to 2 serologically different substrains of the species, were cyclically transmitted to rabbits and monkeys by g. morsitans or g. tachinoides. sera collected from the infected animals were tested for agglutinating antibodies to 17 different serotype antigens prepared from rodent-adapted isolates of t. gambiense. the first antibodies detected in sera from all of the animals agglutinated the same serotype antigen l2, indicating that it possibly consisted of ... | 1975 | 49958 |
| caveola--vesicle complexes in the plasmalemma of erythrocytes infected by plasmodium vivax and p cynomolgi. unique structures related to schüffner's dots. | erythrocytes infected with plasmodium vivax and p cynomolgi, characterized by schüffner's dots on giemsa-stained thin films, were studied by electron microscopy and immunocytochemistry. a caveola-vesicle complex, which consisted of a caveola surrounded by vesicles, in an alveolar fashion, formed along the erythrocyte plasmalemma. horseradish-peroxidase-labeled immunoglobulin from a monkey infected with p vivax bound to the vesicle membrane. cationized ferritin appeared within the vesicles after ... | 1975 | 50017 |
| bilateral projections from precentral motor cortex to the putamen and other parts of the basal ganglia. an autoradiographic study in macaca fascicularis. | by tracing radioactively labeled proteins transported by axonal flow, projections from area 4 to the ipsi- and contralateral neostriatum and claustrum were demonstrated in 7 monkeys. a reversed topographic organization was found on both sides for the corticoneostriatal and corticoclaustral projections. the most extensive terminal field could be observed in the putamen. in contrast, very few area 4 efferents seemed to terminate in the caudate nucleus. this suggests differential functions for the ... | 1975 | 50112 |
| single unit activity in basal ganglia of monkeys during performance of a delayed response task. | single unit activity was recorded from the basal ganglia (caudate, putamen and globus pallidus) of monkeys during the performance of a delayed-response task. the task was divided into five epochs: stimulus onset, delay, pre-response, post-response and reqard. a high percentage of units recorded from the basal ganglia were found to show significant changes in activity during one or more epochs. examination of the proportion of units excited or inhibited during a particular epoch indicated that br ... | 1975 | 50201 |
| preliminary characterization of a major allergen of timothy grass pollen. | previous studies with timothy pollen extracts demonstrated that a low molecular weight dialyzable fraction, antigen d, possessed the allergenic determinant of the major allergen of timothy pollen (allergen b). bio-gel p-2 gel-filtration of the dialysate fraction resulted in the isolation of a fragment, antigen d3 with a molecular weight near 1000. the relationship of antigen d3 to the antigenic and allergenic determinants of allergen b was evaluated by passive cutaneous anaphylaxis (pca) in guin ... | 1975 | 50243 |
| antibody response in the parotid fluid and serum of irus monkeys (macaca fascicularis) after local immunization with streptococcus mutans. | the antibody response of macaca fascicularis in parotid saliva and serum to local immunization by two routes with streptococcus mutans was studied and compared over 1 year. antibodies were titrated and classified by indirect immunofluorescent staining using specific antiglobulin conjugates. antiglucosyltransferase activity was assayed by an enzyme inhibition test. animals were immunized first by injecting formalin-killed bacterial cells and cell products subcutaneously into the vicinity of the f ... | 1975 | 50286 |
| mutual modification of glucose-stimulated serum insulin responses in female rhesus monkeys by ethinyl estradiol and nortestosterone derivatives. | changes in iv glucose tolerance (ivgtt) and serum insulin responses to glucose infusion have been measured in intact female rhesus monkeys treated per os with norethindrone or medroxyprogesterone acetate (500 mug/day) both alone and in combination with mestranol or ethinyl estradiol (10 mug/day) orally for 3 weeks. when administered as the sole contraceptive steroid, neither norethindrone, medroxyprogesterone acetate, mestranol, or ethinyl estradiol produced consistent changes in fasting serum i ... | 1975 | 50326 |
| letter: binding of 25-hydroxy vitamin d2 to plasma protein in new world monkeys. | | 1975 | 50562 |
| the neuraminidase yield-reduction bioassay of human other interferons. | the production of neuraminidase by the recombinant influenza virus x7(f1) in human monkey, rabbit, hamster, mouse, and chicken cell cultures is inhibited by interferon. described is a new enzyme assay for neuraminidase that can be applied to the bioassay of interferons. the advantages of this interferon bioassay are its sensitivity, reproducibility, rapidity, and convenience. | 1975 | 50598 |
| antigenic activity in monkey and human of purified low molecular weight fractions of timothy pollen. | small molecular weight fractions obtained from dialysis of crude timothy pollen extract were shown to carry immunogenic activity in monkeys. three fractions were sequentially purified through gel filtration with siphadex g-10 and c-m cellulose 52. monkeys immunized with these fractions produced almost exclusively skin-sensitizing antibodies which were shown to be of the ige class and differing in antigenic specificity. the analysis of sugars and amino acids contained in two of these fractions sh ... | 1975 | 50725 |
| endogenous primate and feline type c viruses. | 1. endogenous type c viruses have been detected in a wide variety of mammalian species. multiple copies of related, but not identical, virogene sequences can be found in the dna of these species. 2. the endogenous type c virogenes are subject to the pressures of natural selection, and closely related species possess related virogene sequences. these genes evolve as cellular entities diverging from one another in a manner which correlates well with taxonomic relatedness of the species. 3. the end ... | 1975 | 50895 |
| [cerebellar movement disorders in monkeys. comparison of rapidly alternating and slower target movements during cooling of the dentate nucleus (author's transl)]. | the effects of short reversible cooling of the dentate nucleus in two groups of 3 and 4 cebus monkeys, with two different types of ipsilateral elbow movements, have been studied. one group was trained to turn a moving handle back and forth rapidly between two mechanical stops, while the second group was trained to move the handle between two target zones. brief blocking of the dentate nucleus caused a delayed termination of contraction of the agonistic muscles (hypermetria) near the mechanical s ... | 1975 | 51058 |
| dc potentials of temporal lobe seizures in the monkey. | in 8 monkeys, made epileptic by alum or penicillin injection into temporal lobe structures, 40 seizures were studied by both dc cortical potential and subcortical eeg recordings. eighteen seizures of lateral temporal origin had an abrupt negative dc potential shift of 0.5 to 2.0 mv in and around the focus. the frontal, parietal and occipital cortices did not develop dc potential changes, perhaps due to the limited propagation of the neocortical seizures. twenty-two seizures of medial temporal or ... | 1975 | 51061 |
| human glomerular cells in tissue culture. | cells from human glomeruli explanted in tissue culture were grown and subcultivated up to 12 to 13 times. light and electron microscopic studies revealed these cells to be morphologically distinct from fibroblasts. by electron microscopy, an extracellular material resembling basal lamina was seen and prominent intracellular microfilaments were evident. immunofluorescent microscopy demonstrated reactivity of heterologous antiglomerular basement membrane antibody with aggregates of extracellular m ... | 1975 | 51134 |
| studies on the prevalence of type c virus associated with gibbon hematopoietic neoplasms. | gibbon malignancy frequently involves the hematopoietic system and can occur in clusters. virus isolated from gibbon neoplasms possessed typical type c virus morphology, and the virion measured 100 nm in diameter with an electron-dense nucleoid measuring approximately 75 nm. the virus incorporated 3h-uridine into the nucleic acid and rested at a buoyant density of 1.14-1.16 g/cm3. intra-and interspecific antigenic determinants were present, and the intraspecific antigenic determinant was shared ... | 1975 | 51628 |
| visual cortex responses to abrupt changes in the periodicity of rapidly intermittent light. | visually evoked potentials that are stimulated by period-jumps in a high-frequency modulated luminance have been detected and studied experimentally in monkeys. the visual responses are shown quantitatively by a principal components analysis to depend remarkably simply, in shape and in amplitude, on the period-jump stimulus. the response shape is nearly invariant, except that the early part of the response shows a distinctive (though slight) dependence on the sign of the period-jump. the respons ... | 1975 | 51713 |
| protein polymorphism in the hanuman langur (presbytis entellus). | 26 specimens of presbytis entellus were examined for a variety of blood proteins. in contrast to previous studies of other species of leaf monkeys, our p.entellus sample proved to be very heterogeneous. polymorphisms were found in the third component of complement, group-specific component, glycine-rich beta-glycoprotein, alpha1-antitrypsin, phosphoglucomutase, 6-phosphogluconate dehydrogenase, adenylate kinase, superoxide dismutase, malate dehydrogenase, and phosphohexose isomerase. variable ba ... | 1975 | 51813 |
| the isolation of allergens from the green pea. | the aqueous extract of green peas was separated into 3 fractions (albumin, legumin, and vicilin) by dialysis against distilled water and isoelectric precipitation. the major antigenic and all of the allergenic activity of the pea extract was associated with the albumin fraction. the albumin fraction retains its allergenicity upon heating at 60 degrees c for 30 min or boiling at 100 degrees c for 5 min, but becomes partially inactivated by autoclaving at 120 degrees c for 15 min. the allergenic d ... | 1975 | 51864 |
| antigenic determinants of the 70,000 molecular weight glycoprotein of woolly monkey type c rna virus. | the 70,000 molecular weight glycoprotein (gp70) of a type-c rna virus originally isolated from a woolly monkey has been partially purified and immunologically characterized. evidence that this viral protein is viral coded was derived from studies showing its antigenic properties to be unaltered by virus passage in cells of different species. a broadly reactive competition immunoassay was developed utilizing antiserum prepared against feline leukemia virus to precipitate 125i-labeled woolly monke ... | 1975 | 51882 |
| biochemical properties of the bromodeoxyuridine-induced guinea pig virus. | the biophysical and biochemical properties of the virus particles released by guinea pig embryo cells treated with 5-bromo-2'-deoxyuridine (budr) have been compared to those of the b-type mouse mammary tumor virus (mmtv) and the c-type rauscher murine leukemia virus. the high-molecular-weight (60 to 70s) rna of the budr-induced guinea pig virus (gpv) has a molecular weight of 8 x 106 when measred by mixed agarose polyacylamide gel electrophoresis. the virus particles isolated from the tissue cul ... | 1975 | 51933 |
| infective transmission and characterisation of a c-type virus released by cultured human myeloid leukaemia cells. | a c-type virus isolated from long term cultures of myeloid cells from a patient with acute myelogenous leukaemia is infectious for a wide variety of cells. the establishment of chronically infected cells enabled us to characterise the virus by biological, immunological, and biochemical tests. the virus is closely related to the simian sarcoma-associated virus isolated from a woolly monkey fibrosarcoma. | 1975 | 52117 |
| relevance of some poxvirus infections in monkeys to smallpox eradication. | | 1975 | 52212 |
| [bone marrow lymphocytes (b-cells) in intact and thymus-deficient dogs and monkeys]. | | 1975 | 52242 |
| purified low molecular weight fractions of timothy pollen extracts: immunochemistry and immunogenic activity in the monkey. | | 1975 | 52599 |
| the histochemical demonstration of aminopeptidase with bromoindolyl leucinamide. | the indigogenic method for aminopeptidase of pearson et al. (1963) was critically evaluated. the localization obtained with it is not correct due to diffusion artifacts. ferricyanide cannot be used as an oxidation agent. based on experiments with other oxidation agents (phenazonium methosulfate, nitro bt, tetranitro bt) a new method was devised. the recommended incubation medium contains 0.9 mm l-n-(5-bromoindol-3-yl) leucinamide hydrobromide (chloride), 0.73 mm tetranitro bt, 0.27 mm phenazoniu ... | 1975 | 52636 |
| the release of membrane antigens into culture by adult schistosoma mansoni. | antigens sharing determinants with surface membranes and soluble proteins of adult schistosoma mansoni have been detected in culture media after incubation of radioactively labelled worms. the relative quantities of these antigens were measured with specific antisera raised in rabbits and with serum from an immune rhesus monkey. it was found that 12-16% of tca-precipitable radioactivity in the culture medium consisted of membrane antigens and 6-8% consisted of antigens sharing determinants with ... | 1975 | 52859 |