| anatomical distribution of developing trophozoites and schizonts of plasmodium vivax in aotus lemurinus lemurinus and saimiri sciureus. | organ distribution of developing trophozoite- and schizont-infected erythrocytes of plasmodium vivax and night monkeys, aotus lemurinus lemurinus, and squirrel monkeys, saimiri sciureus, was determined. the primary site for the infection in both species was the splenic vasculature. secondary organ involvement differed between hosts although some overlapping did occur. | 1990 | 2191104 |
| projection from the external pallidum to the reticular thalamic nucleus in the squirrel monkey. | small injections of biocytin in the external segment of the pallidum (gpe) of the squirrel monkey (saimiri sciureus) led to anterograde labeling of fibers in the thalamic reticular nucleus (nrt). these fibers reached nrt by coursing along the ventral tip of the internal capsule or by directly piercing the internal capsule more dorsally. they arborized profusely within the entire rostrocaudal extent of the nucleus. within nrt, biocytin-labeled fibers were long, slightly varicosed, and emitted num ... | 1991 | 1716174 |
| the peruvian iii strain of plasmodium brasilianum in saimiri sciureus boliviensis monkeys. | a strain of plasmodium brasilianum was isolated from a naturally infected saimiri monkey from peru and subsequently passaged to 21 splenectomized saimiri sciureus boliviensis monkeys. nine of 12 attempts to transmit infection by sporozoite inoculation were successful with prepatent periods ranging from 23 to 41 days. gametocytes were infective to anopheles freeborni, anopheles stephensi, anopheles dirus, anopheles maculatus, and anopheles gambiae mosquitoes. the strain demonstrated a high level ... | 1990 | 2213410 |
| transmission of plasmodium fragile to saimiri monkeys. | saimiri monkeys from bolivia and guyana were infected with the nilgiri and ceylon strains of plasmodium fragile. of 20 attempted sporozoite transmissions of the ceylon strain involving 11 splenectomized saimiri sciureus boliviensis, only 8 were successful, 2 by mosquito bite and 6 by intravenous injection of sporozoites dissected from salivary glands. prepatent periods ranged from 18 to 30 days with a mean of 25.8 days. | 1990 | 2213417 |
| number-related discrimination and summation by squirrel monkeys (saimiri sciureus sciureus and s. boliviensus boliviensus) on the basis of the number of sides of polygons. | in experiment 1, with the number of sides or angles of irregular polygons as cues, programmed training, and a 90% correct criterion (36 of 40), 2 squirrel monkeys' (saimiri sciureus sciureus and s. boliviensus boliviensus) best performances were to discriminate heptagons from octagons, a 3rd's best was hexagons from heptagons, and a 4th's best was pentagons from heptagons. in experiment 2, on most trials 2 polygons on one or both discriminanda had to be summed to determine which discrimination h ... | 1990 | 2225761 |
| thalamically projecting cells of the lateral cervical nucleus in monkey. | the number, location, and morphology of thalamically projecting lateral cervical nucleus (lcn) cells were determined in monkey using retrograde transport of wheatgerm agglutinin-conjugated horseradish peroxidase. these data were compared to the total population of lcn neurons as determined by nissl stain. in 4 macaca fascicularis and one saimiri sciureus the average size of the thalamic projection from lcn was found to be 506 +/- 94 cells contralateral to the injections. thalamically projecting ... | 1991 | 1718552 |
| amyloid in the brains of aged squirrel monkeys. | in this immunocytochemical study, the brains of nine squirrel monkeys (saimiri sciureus), ranging from 8 to 27 years of age, were examined for the presence and distribution of beta/a4 amyloid, a 4-kilodalton peptide. in aged squirrel monkeys, amyloid is associated primarily with intracerebral and meningeal capillaries and arterioles and occurs to a lesser degree as small and/or diffuse deposits in the neural parenchyma and in the dense cores of senile plaques. cerebrovascular amyloid is found pr ... | 1990 | 2239150 |
| corticostriatal transformations in the primate somatosensory system. projections from physiologically mapped body-part representations. | 1. the basal ganglia of primates receive somatosensory input carried largely by corticostriatal fibers. to determine whether map-transformations occur in this corticostriatal system, we investigated how electrophysiologically defined regions of the primary somatosensory cortex (si) project to the striatum in the squirrel monkey (saimiri sciureus). receptive fields in the hand, mouth, and foot representations of cortical areas 3a, 3b, and 1 were mapped by multiunit recording; and small volumes of ... | 1991 | 1722244 |
| morphologic development of the adrenal cortex in squirrel monkeys (saimiri sciureus). | this study describes the morphology of the squirrel monkey (saimiri sciureus) adrenal gland in the perinatal period. adrenals of fetal monkeys had a broad central zone of large eosinophilic cells (fetal zone) surrounded by a subcapsular band of small dark cells (definitive zone). adrenals of stillborn and neonatal monkeys had a reduced fetal zone and an expanded definitive zone that was differentiated into distinct zona fasciculata and zona glomerulosa. by day 18 postpartum, no remnant of the fe ... | 1990 | 2254916 |
| development of a polymorphic strain of plasmodium vivax in monkeys. | a strain of plasmodium vivax from thailand with a polymorphic repeat unit of the circumsporozoite protein was established in saimiri sciureus boliviensis and 3 species of aotus monkeys. all 11 attempts to transmit infection via sporozoite inoculation, 4 times to splenectomized s. sciureus boliviensis, 2 times to splenectomized aotus nancymai, and 5 times to intact saimiri monkeys, were successful. anopheles freeborni, anopheles stephensi, anopheles dirus, and anopheles gambiae mosquitoes were in ... | 1992 | 1597793 |
| a rhoptry antigen of plasmodium falciparum is protective in saimiri monkeys. | a non-polymorphic antigen associated with the rhoptry organelles of plasmodium falciparum has been purified by immunoaffinity chromatography. the antigen, rap-1 (rhoptry associated protein-1), which is defined by monoclonal antibodies which inhibit parasite growth in vitro, is a multi-component antigen consisting of four major proteins of 80, 65, 42 and 40 kda and two minor proteins of 77 and 70 kda. these proteins were electro-eluted from preparative sodium dodecyl sulphate polyacrylamide gels ... | 1990 | 2263413 |
| peripheral blood mononuclear cells in the squirrel monkey saimiri sciureus. ii. exploration of the il2/il2r pathway of t-cell activation. | we report here on functional aspects of squirrel monkey t cells isolated either from peripheral blood mononuclear cells or in the presence of accessory cells or accessory-cell-secreted cytokines. the t-cell response triggered by polyclonal activators was measured through proliferation, t-cell growth factor production and transient expression of receptors to growth factors. we also sought to delineate mechanisms by which antimitogenic molecules might prevent lymphocytes from being able to express ... | 1991 | 1796209 |
| contralateral pallidothalamic and pallidotegmental projections in primates: an anterograde and retrograde labeling study. | unilateral injections of the anterograde tracer phaseolus vulgaris-leucoagglutinin (pha-l) in the internal segment of the pallidum (gpi) of the squirrel monkey (saimiri sciureus) led to anterograde labeling of fibers ipsilaterally in the following thalamic nuclei: ventral anterior (va), ventral lateral (vl), centromedian (cm), and lateral habenula (hbl). the labeled fibers reached these ipsilateral thalamic nuclei by coursing along or through the ansa lenticularis, the lenticular and thalamic fa ... | 1991 | 1817727 |
| reduced nicotinamide adenine dinucleotide phosphate-diaphorase (nadph-d) profiles in the amygdala of human and new world monkey (saimiri sciureus). | the topographic distribution of nicotinamide adenine dinucleotide-diaphorase (nadph-d) stained profiles in the amygdala of the human and new world monkey (saimiri sciureus) were studied histochemically. fiber and terminal staining were heterogeneously distributed within the amygdala. the most intense staining occurred in the basolateral subdivision, consisting of the lateral, basolateral and accessory basal nuclei. moderate staining intensity was observed throughout the cortical and media nuclei ... | 1992 | 1606498 |
| visual p3-like potentials in squirrel monkey: effects of a noradrenergic agonist. | event-related potentials (erps) were recorded from squirrel monkeys (saimiri sciureus) in a 90-10 visual "oddball" paradigm. a small, blue rectangle was presented every 2 s on 90% of the trials (background), whereas a yellow rectangle occurred on 10% on the trials (oddball). electrical activity time-locked to these stimulus events was recorded from epidural electrodes before and following systemic administration of the alpha-2 noradrenergic agonist clonidine (0.1 mg/kg intramuscularly, im). base ... | 1992 | 1591604 |
| subcutaneous leiomyosarcoma in a peruvian squirrel monkey (saimiri sciureus). | | 1990 | 2345936 |
| efferent connections of the centromedian and parafascicular thalamic nuclei in the squirrel monkey: a light and electron microscopic study of the thalamostriatal projection in relation to striatal heterogeneity. | the organization of the thalamostriatal projections arising from the centromedian (cm) and parafascicular (pf) thalamic nuclei in the squirrel monkey (saimiri sciureus) was studied at both light and electron microscopic levels. following selective injections of the anterograde axonal tracer phaseolus vulgaris-leucoagglutinin (pha-l) into the cm or pf, patterns of terminal arborization within the striatum were compared to the biochemical heterogeneity of the striatum as revealed by immunohistoche ... | 1992 | 1619051 |
| distribution of chromosomal polymorphisms in three subspecies of squirrel monkeys (genus saimiri). | the presence of nucleolar organizer regions (nors) and c-band polymorphisms has been examined in three subspecies of squirrel monkeys, saimiri sciureus sciureus, s. boliviensis boliviensis, and s. boliviensis peruviensis. pericentric inversions in chromosomes 15 and 16 were also examined in the three groups. chromosome 15 was acrocentric in s. s. sciureus and submetacentric in s.b. boliviensis and s.b. peruviensis. chromosome 16 was acrocentric in s.s. sciureus and s.b. boliviensis while being s ... | 1990 | 2369837 |
| alcohol dose and low density lipoprotein heterogeneity in squirrel monkeys (saimiri sciureus). | the present study was designed to determine whether normolipidemic male squirrel monkeys (saimiri sciureus) exhibit low density lipoprotein (ldl) heterogeneity similar to that observed in humans and if present, whether ldl subfractions are altered by consumption of low vs. high dose ethanol (etoh). primates were divided into three groups designated control, low, and high etoh and fed isocaloric liquid diets containing 0%, 12% and 24% of calories as etoh, respectively, for 6 months. the 12% etoh ... | 1992 | 1632875 |
| leishmania braziliensis in the squirrel monkey: development of primary and satellite lesions and lack of cross-immunity with leishmania donovani. | three female and 2 male adult laboratory-reared squirrel monkeys (saimiri sciureus) that previously had been inoculated with leishmania (leishmania) donovani and had recovered from experimental visceral leishmaniasis were each inoculated intradermally at the dorsal base of the tail with 2.2 x 10(7) culture-derived promastigotes of leishmania (viannia) panamensis. the progression and regression of subsequent lesions were examined for 36 wk in all 5 monkeys after which 3 of the monkeys were killed ... | 1990 | 2380874 |
| brain stimulation-induced changes of phonation in the squirrel monkey. | in 11 squirrel monkeys (saimiri sciureus), the brain stem was systematically explored with electrical brain stimulation for sites affecting the acoustic structure of ongoing vocalization. vocalization was elicited by electrical stimulation of different brain structures. a severe deterioration of the acoustical structure of vocalization was obtained during stimulation of the caudoventral part of the periaqueductal grey, lateral parabrachial area, cortico-bulbar tract, nucl. ambiguus and surroundi ... | 1992 | 1644120 |
| a comparative study of neonatal skeletal development in cebus and other primates. | comparisons of hand/wrist radiographs of neonatal cebus albifrons (n = 14) and cebus apella (n = 4) with those of saimiri sciureus boliviensis (n = 9) and macaca mulatta (n = 63) reveal that the cebid monkeys show much less skeletal ossification at birth than macaques. differences in gestation time alone cannot account for the differences in skeletal maturity at birth in the two groups of monkeys. the skeletal precocity of the newborn macaques indicates that their ossification either begins earl ... | 1990 | 2391051 |
| dietary restriction and aging: the initiation of a primate study. | juvenile (1 yr) and adult (3-5 yr) male rhesus monkeys (macaca mulatta) and juvenile (1-4 yr) and adult (5-10 yr) male squirrel monkeys (saimiri sciureus) were fed a diet at or near ad libitum levels based on recommended caloric intake for age and body weight or fed 30% less of the same diet with this restriction gradually introduced over a 3-mo period. analysis of body weights among these respective control and experimental groups from the first year of the study indicated that the monkeys unde ... | 1990 | 2394908 |
| evidence of an x zone in lobule v of the squirrel monkey (saimiri sciureus) cerebellum: the distribution of corticonuclear fibers. | the distribution of corticonuclear fibers to medial-most parts of the posterior interposed nucleus (nip) from lateral areas of the vermis was studied in the squirrel monkey (saimiri sciureus), using a silver impregnation method. the origin and course of degenerated fibers were studied in serial sections. the distribution pattern of corticonuclear fibers from a series of small well localized lesions placed in the vermis and paravermal cortex of lobule v is compatible with the interpretation that ... | 1991 | 1665319 |
| anatomic evidence of nociceptive inputs to primary somatosensory cortex: relationship between spinothalamic terminals and thalamocortical cells in squirrel monkeys. | this study examined anatomic pathways that are likely to transmit noxious and thermal cutaneous information to the primary somatosensory cortex. anterograde and retrograde labeling techniques were combined to investigate the relationship between spinothalamic (stt) projections and thalamocortical neurons in the squirrel monkey (saimiri sciureus). large injections of diamidino yellow (dy) were placed in the physiologically defined hand region of primary somatosensory cortex (hsi), and wheat germ ... | 1991 | 1865012 |
| the monoaminergic innervation of the amygdala in the squirrel monkey: an immunohistochemical study. | the monoaminergic innervation of the amygdala of the squirrel monkey (saimiri sciureus) was studied by using immunohistochemical methods with primary antisera raised against serotonin, and the catecholamine synthesizing enzymes tyrosine hydroxylase, dopamine-beta-hydroxylase and phenylethanolamine-n-methyltransferase. serotonin was widely distributed within the amygdala including profuse terminal labeling in central, basolateral and cortical nuclear groups. the accessory basal and medial nuclei ... | 1990 | 1977101 |
| biological control of primate macular pigment. biochemical and densitometric studies. | the amounts of zeaxanthin (z) and lutein (l), the carotenoids constituting the primate macular pigment, were measured in the central retinas of monkeys (saimiri sciureus and macaca fascicularis). two independent methods--reverse-phase high-performance liquid chromatography (hplc) and microdensitometry--were used for analysis of the same set of retinas. most of the measurements were made on retinas that had been fixed by glutaraldehyde-paraformaldehyde perfusion of the animal. control experiments ... | 1991 | 1993576 |
| serologic evidence of encephalitozoon cuniculi infection in a colony of squirrel monkeys (saimiri sciureus). | five hundred seventeen serum samples obtained during 3 years from a collection of 250 squirrel monkeys were examined by indirect immunofluorescence and dot-elisa for antibodies to encephalitozoon cuniculi. one hundred seventy-nine monkeys were positive at least once and fifty six monkeys were positive three or more times. older animals were more likely to be positive than young animals, but the proportion of serologically positive monkeys did not change appreciably over the 3 years. as judged by ... | 1989 | 2503661 |
| differences in mineral metabolism among nonhuman primates receiving diets with only vitamin d3 or only vitamin d2. | we tested for differences in aspects of mineral metabolism during the administration of diets with only vitamin d3 or only vitamin d2 in four nonhuman anthropoid primate species [two catarrhini, macaca fascicularis (crab-eating macaque) and macaca mulatta (rhesus macaque), and two platyrrhini, saimiri sciureus (squirrel monkey) and aotus vociferans (night monkey)]. all four species maintained approximately 2- to 3-fold higher serum 25-hydroxyvitamin d (25ohd) level while receiving vitamin d3 tha ... | 1989 | 2555385 |
| distribution of individual macular pigment carotenoids in central retina of macaque and squirrel monkeys. | the spatial distribution of lutein (l) and zeaxanthin (z), the structural isomers composing the macular pigment, was studied in the retinas of macaque monkeys (macaca fascicularis) and squirrel monkeys (saimiri sciureus). spatial profiles of macular pigment optical density were obtained from retinal whole mounts. then concentric annuli were microdissected from the fovea and adjacent regions of the same retinas. each retinal segment was analyzed for carotenoids by high-performance liquid chromato ... | 1991 | 1993577 |
| renal response to 7 days of lower body positive pressure in squirrel monkeys. | the purpose of this study was to characterize the renal response to central volume expansion using lower body positive pressure (lbpp) in the adult male squirrel monkey (saimiri sciureus). urinary excretion of sodium, potassium, and water and plasma aldosterone concentrations were measured during a control day, 7 days of lbpp, and a recovery day. time control experiments in the same animals included chair sitting without exposure to lbpp. seven monkeys (600-1,000 g) were trained to sit in a spec ... | 1991 | 2012244 |
| renal pathology in saimiri monkeys during a vaccine trial using the recombinant circumsporozoite protein of plasmodium vivax. | renal specimens of squirrel monkeys (saimiri sciureus boliviensis) were studied by light microscopy and immunohistochemistry to examine the pathologic changes during vaccine trials with four recombinant circumsporozoite (cs) proteins (rpvcs-1, rpvcs-2, rpvcs-3, ns1(81) v20) of plasmodium vivax. the monkeys were vaccinated and later challenged with p. vivax sporozoites. among the 33 posttrial biopsies, 17 had mild to moderate mesangial proliferation and nine had interstitial nephritis. immunohist ... | 1991 | 2042706 |
| delta activity from amygdala in squirrel monkeys (saimiri sciureus): influence of social and environmental context. | a previous study reported that power in the delta band of the amygdala is selectively elevated when primates are exposed to affectively ladened stimuli (kling, steklis, & deutsch, 1979). radiotelemetric recordings suggested that this elevation was greatest when the animal was confronted with conspecific behaviors that could be interpreted as "ambiguous." in the present study, a specific elevation of delta activity was observed when the animal was placed in an environment in which uncued shock ha ... | 1991 | 2043270 |
| breeding readiness in squirrel monkeys: female-primed females are triggered by males. | the south american squirrel monkey (saimiri) shows pronounced annual variations in reproductive activity. we investigated the contribution of social stimulation to breeding readiness, as reflected in behavior and gonadal hormones. a previous study indicated that formation of new heterosexual pairs can induce breeding readiness in males, but not in females. in the present study we examined the response of individually housed females to the formation of triads of unacquainted females and, subseque ... | 1991 | 2062922 |
| testing of plasmodium vivax cs proteins in saimiri monkeys. | recombinant proteins directed against the circumsporozoite (cs) protein of plasmodium vivax were tested for safety, immunogenicity, and efficacy in saimiri sciureus boliviensis monkeys. the monkeys were immunized 3 times with either alum or muramyl tripeptide as adjuvant, and were challenged with 10,000 sporozoites (p. vivax, salvador i strain) from mosquitos infected by membrane feeding on gametocytes from chimpanzees. antibodies, measured by indirect immunofluorescent antibody tests and enzyme ... | 1990 | 2094590 |
| lithium lengthens circadian period in a diurnal primate, saimiri sciureus. | lithium lengthens the period of free-running circadian rhythms in a variety of species, but this effect has not been demonstrated unequivocally in primates. because of the possible link between lithium's action on the circadian clock and its therapeutic action in human mood disorders, we tested the ability of lithium to lengthen circadian period in a diurnal primate with circadian properties similar to those of humans. lithium carbonate was administered in food pellets to 8 adult male squirrel m ... | 1990 | 2116188 |
| the compartmentalization of the monkey and rat cerebellar cortex: zebrin i and cytochrome oxidase. | the cerebellar cortex of mammals is composed of parasagittal zones that encompass the afferent inputs, the efferent corticonuclear and corticovestibular projections, and a number of intrinsic molecular markers. one such marker is the polypeptide antigen zebrin i that is recognized by monoclonal antibody (mab) q113. in rodents, zebrin i immunocytochemistry reveals an array of parasagittal purkinje cell compartments. in the present study, zebrin i has been used to reveal the molecular heterogeneit ... | 1990 | 2154279 |
| immunohistochemical study of the serotoninergic innervation of the basal ganglia in the squirrel monkey. | a specific antibody raised against 5-hydroxytryptamine (5-ht) conjugated to bovine serum albumin was used to study the serotoninergic innervation of the basal ganglia in the squirrel monkey (saimiri sciureus). at midbrain level, numerous fine 5-ht-immunoreactive axons were seen to arise from the immunopositive neurons of the dorsal raphe nucleus and less abundantly from those of the nucleus centralis superior. the bulk of these axons formed a rather loosely arranged bundle that arched ventrorost ... | 1990 | 2212111 |
| the uganda i/cdc strain of plasmodium malariae in saimiri sciureus boliviensis. | the uganda i/cdc strain of plasmodium malariae, initially adapted to monkeys of the genus aotus, was studied in splenectomized saimiri sciureus boliviensis. mean maximum parasitemia ranged from 248 to 22,134/mm3. only 1 mosquito was infected of 2,238 examined. after the parasite was adapted to this host, infections were characterized by periods of detectable parasitemia extending up to 269 days and by sustained periods when parasite counts were greater than 1,000/mm3. after 4 linear passages, th ... | 1989 | 2647957 |
| immunization of saimiri sciureus boliviensis with recombinant vaccines based on the circumsporozoite protein of plasmodium vivax. | we report a trial in squirrel monkeys of 2 recombinant plasmodium vivax malaria vaccine candidates based on the circumsporozoite (cs) protein. one recombinant (nsl81v20), produced in escherichia coli, contains the repeat region of the cs protein. the other (vivax-1) recombinant is yeast-derived and contains the entire repeat domain and part of the surrounding n-terminal and c-terminal regions. both antigens were administered with alum and muramyl tripeptide as adjuvants. no formulations caused t ... | 1989 | 2658634 |
| light suppression of melatonin in the squirrel monkey (saimiri sciureus). | this study examined plasma melatonin levels and the suppressant effect of light on melatonin production in the squirrel monkey. monkeys were maintained on a 12:12 light-dark cycle (ld 12:12) with lights on from 07:00 to 19:00. plasma levels of melatonin were determined by gas chromatography negative chemical ionization mass spectrometry. melatonin levels at 00:00 (99.5 +/- 18.9 pg/ml) were significantly higher than at 02:00 (57.21 +/- 7.7 pg/ml; student's t = 2.859; p less than or equal to 0.021 ... | 1990 | 2231270 |
| intestinal trichomonads (tritrichomonas mobilensis) in the natural host saimiri sciureus and saimiri boliviensis. | a retrospective study of cecal and colonic tissues from 28 squirrel monkeys (saimiri sciureus and saimiri boliviensis) demonstrated enteric trichomonads within luminal crypts. twenty-one of 28 (75%) had trichomonads in the mucosal epithelium either in cup-like depressions or intraepithelial vacuoles. organisms were also beneath the superficial luminal mucosal epithelium and between the basement membrane and crypt epithelial cells. immunoperoxidase staining also identified organisms within the la ... | 1989 | 2711571 |
| functional characterization of the antibody-mediated protection against blood stages of plasmodium falciparum in the monkey saimiri sciureus. | the squirrel monkey saimiri sciureus is one of the world health organization recommended experimental models of plasmodium falciparum blood stage infection. anti-malaria antibodies developed by this host after a drug-controlled infection play an important part in the acquired protection against the p. falciparum blood stages. furthermore, the use of two anti-saimiri immunoglobulin (ig) monoclonal antibodies (mab) has permitted the differentiation between protective (mab 3a2/g6) and non-protectiv ... | 1990 | 2242760 |
| partial humeri of two miocene colombian primates. | distal portions of humeri from two miocene colombian primates were recovered during field work in 1986. the larger igm 183420 is very similar in size and morphology to the humerus included in the type specimen of cebupithecia sarmientoi, recovered from la venta in 1945 (stirton and savage: serv. geol. nac. bogata 7:345-356, 1951) and is assigned to this taxon. igm 183420 presents a number of features of the humerus associated with clinging postural behaviors in living platyrrhines, including a m ... | 1990 | 2327481 |
| vocalization-correlated single-unit activity in the brain stem of the squirrel monkey. | the brain stems of 17 squirrel monkeys (saimiri sciureus) were systematically explored for vocalization-related single-unit activity during calls electrically elicited from the periaqueductal grey. of 12,280 cells tested, 1151 fired in relation to vocalization. of these, 587 reacted to external acoustic stimuli and started firing after vocalization onset. as most of these cells were located in classical auditory relay structures, they probably represent auditory neurones reacting indirectly to s ... | 1991 | 1864326 |
| species-dependent differences in atp half-life of glucose deprived crystalline lens. | 1. significant differences were detected by 31p nmr spectroscopic techniques in the intrinsic rate of atp hydrolysis by crystalline lenses from adult macaca mulatta, saimiri sciureus, felis catus, sus, canis familiaris, cavia rodentia and oryctalagis cuniculus during exogenous glucose deprivation. 2. these differences were not attributable to differences in endogenous glycogen stores, and appear instead to emanate from comparative species differences in lenticular enzyme activities. | 1989 | 2758799 |
| selective degeneration of the parvocellular-projecting retinal ganglion cells in a new world monkey, saimiri sciureus. | selective degeneration of retinal ganglion cells projecting to parvocellular layers of the dorsal lateral geniculate nucleus (lgn) was observed in squirrel monkeys (saimiri sciureus) exposed to a range of doses of acrylamide monomer. similar acrylamide-induced neuronal loss has previously been reported in parvocellular-projecting ganglion cells of macaques, but no such selective degeneration has been found in acrylamide-dosed rats, squirrels, rabbits or cats. the extent of ganglion cell loss obs ... | 1989 | 2478261 |
| brain-stem auditory evoked potentials in squirrel monkey (saimiri sciureus). | to more fully characterize brain-stem auditory evoked potentials (baeps) in non-human primates, baeps were recorded from chronically implanted epidural electrodes in 10 squirrel monkeys (saimiri sciureus). the effects of stimulus intensity, repetition rate, and anesthesia (ketamine 20 mg/kg i.m.) on peak latencies and inter-peak intervals were evaluated. monkey wave forms consisted of approximately 7 peaks (i-vii), each exhibiting similar latencies across sessions, with later peaks exhibiting gr ... | 1989 | 2480887 |
| social status as determinant of alcohol effects on aggressive behavior in squirrel monkeys (saimiri sciureus). | we investigated the behavioral effects of alcohol, especially those on aggression, on members of established groups of squirrel monkeys. a continuous measurement of monkey behavior in groups revealed consistent differences between dominant and subordinate animals. dominant monkeys aggressed more frequently than subordinate monkeys, and spent less time in stationary postures. alcohol produced dose-related biphasic changes in the number of threats, grasps, and displacements exhibited by dominant b ... | 1985 | 2861617 |
| effects of locus coeruleus lesions on auditory, long-latency, event-related potentials in monkey. | it has previously been demonstrated that monkeys exhibit certain event-related potential (erp) components showing latency, polarity, and contingency similarities to those observed in humans. in the present study, monkey p300-like components were studied in order to evaluate the hypothesis that the noradrenergic locus coeruleus (lc) system participates in their generation or modulation. erps were recorded from untrained squirrel monkeys (saimiri sciureus) twice a week for 4 weeks before and after ... | 1989 | 2563282 |
| evidence for a distinct nigropallidal dopaminergic projection in the squirrel monkey. | injections of the retrograde fluorescent tracer fast blue in the striatum (str) and nuclear yellow in the internal segment of the globus pallidus (gpi) in the squirrel monkey (saimiri sciureus) revealed a nigropallidal projection whose cellular origin was largely distinct from that of the nigrostriatal pathway. neurons containing the tracer injected in gpi were scattered throughout the substantia nigra-ventral tegmental area complex where they formed approximately 20-25% of the total number of r ... | 1989 | 2565144 |
| dopaminergic innervation of the basal ganglia in the squirrel monkey as revealed by tyrosine hydroxylase immunohistochemistry. | the organization of the dopaminergic mesostriatal fibers and their patterns of innervation of the basal ganglia in the squirrel monkey (saimiri sciureus) were studied immunohistochemically with an antiserum raised against tyrosine hydroxylase (th). numerous fibers arose from midbrain th-positive cell bodies of the substantia nigra pars compacta (group a9), the retrorubral area (group a8), and the lateral portion of the ventral tegmental area (group a10). these fibers accumulated dorsomedially to ... | 1989 | 2572613 |
| bilirubin excretion and bile flow in fed and fasted brazilian squirrel monkeys (saimiri sciureus). | fasted brazilian squirrel monkeys (brsms) exhibited slightly higher serum bilirubin levels (0.30 +/- 0.05 mg/dl) than others in the fed state (0.13 +/- 0.01). the mean liver weight was 50% lower following a 22 h fast. the rate of bile flow was unaffected by fasting and averaged 13.8 microliters/min/kg and 47.5 microliters/min/100g liver in six brsms. no significant difference in mean bilirubin excretion/min was observed on a body weight basis following fasting. when the mean rate of bilirubin ex ... | 1989 | 2588480 |
| behavioral and endocrine consequences of heterosexual pair formation in squirrel monkeys. | the south american squirrel monkey (saimiri sciureus) typically lives in large social groups containing several individuals of all age/sex categories. when living in established heterosexual pairs, reproduction in this seasonally breeding primate is poor. we attempted to induce breeding activity in pair-housed monkeys by forming new heterosexual pairs just prior to the breeding season. breeding readiness, as reflected in behavior and gonadal hormones, was induced in males, but not in females. ma ... | 1989 | 2602484 |
| corticotropin-releasing factor immunoreactivity in monkey neocortex: an immunohistochemical analysis. | corticotropin-releasing factor (crf) has been implicated in the pathophysiology of certain human neuropsychiatric disorders that affect neocortical function. however, the anatomical organization of crf-containing structures in the expanded and highly differentiated primate neocortex has not been previously described. in this study, the distribution of crf-immunoreactive neurons and processes was characterized in the neocortex of new world squirrel monkeys (saimiri sciureus). substantial regional ... | 1989 | 2613945 |
| plasma carotenoids of monkeys (macaca fascicularis and saimiri sciureus) fed a nonpurified diet. | the major carotenoid pigments in the plasma and in a common, nonpurified diet of two species of monkeys (macaca fascicularis and saimiri sciureus) were measured. the xanthophylls, lutein, zeaxanthin, alpha-cryptoxanthin, and beta-cryptoxanthin, were the principal carotenoids in both the diet and the plasma. lutein and zeaxanthin were abundant in the all-trans, the 9-cis, and the 13-cis geometrical isomers in the diet, but the 9-cis form was rarely measurable in plasma. however, the 13-cis isomer ... | 1990 | 2262812 |
| [management of individual body weight growth of infant squirrel monkey (saimiri sciureus) in indoor breeding colony]. | we biometrically analyzed the body weight growth data of new-born squirrel monkeys, obtained during the nursing period from 0 to 12 weeks of age. body weight (y in grams) could be expressed as a function of birth weight (a in grams) and age (x in weeks) by the following equation: y = a + b x, where b indicates growth rate. this equation corresponded significantly with actual growth curves (r2 = 0.96). the frequency distribution of b values was demonstrated to be abnormal distribution. this value ... | 1990 | 2303094 |
| processing of amplitude modulated sounds in the medial geniculate body of squirrel monkeys. | the responses of single and multi units in the medial geniculate body of the squirrel monkey (saimiri sciureus) to modulation frequency, modulation depth and changes in absolute intensity of sinusoidally amplitude modulated (am) sounds were studied. both spike-frequency and spike rate modulation were used as a measure for neuronal response. spike rate modulation was derived from fft (fast-fourier-transformation) analysis of the psths. in all cases (n = 133) spike rate modulation was shown to be ... | 1990 | 2311698 |
| efferent projections of the subthalamic nucleus in the squirrel monkey as studied by the pha-l anterograde tracing method. | the organization of the efferent connections of the subthalamic nucleus was studied in the squirrel monkey (saimiri sciureus) by using the lectin phaseolus vulgaris-leucoagglutinin (pha-l) as an anterograde tracer. at the level of the basal forebrain, anterogradely labeled fibers and axon terminals were mostly found in the striatopallidal complex and the substantia innominata. in cases in which the pha-l injection sites were placed in the central or the lateral third of the subthalamic nucleus, ... | 1990 | 2332533 |
| a region of the herpesvirus saimiri genome required for oncogenicity. | herpesvirus saimiri naturally infects squirrel monkeys (saimiri sciureus) without producing signs of disease; infection of other new world primates, however, results in a rapidly progressing, malignant, t-cell lymphoma. results described in this report identify a region of the viral genome that is required for oncogenicity in owl monkeys (aotus trivirgatus); this region is not required for replication of the virus. this is believed to be the first such genomic region identified in a herpesvirus ... | 1985 | 2983431 |
| reduced nicotinamide adenine dinucleotide phosphate-diaphorase (nadph-d) histochemistry in the hippocampal formation of the new world monkey (saimiri sciureus). | nicotinamide adenine dinucleotide phosphate-diaphorase (nadph-d) containing fibers and neurons within the hippocampal formation and entorhinal cortex of the new world monkey were determined using a direct histochemical procedure. occasional intensely stained bipolar nadph-d positive neurons were seen in the polymorphic zone within the hilus of the dentate gyrus and molecular layer of the hippocampus. although virtually no intensely stained cells were seen in the ca subfields, a few small oval li ... | 1990 | 2364290 |
| retinal vasculature of the fovea of the squirrel monkey, saimiri sciureus: three-dimensional architecture, visual screening, and relationships to the neuronal layers. | the retinal vasculature of the fovea of squirrel monkeys was studied in retinal whole mounts and in sections of the same retinas. at the center of the fovea there is an approximately circular avascular zone surrounded by a set of terminal capillaries in the inner nuclear layer. within the foveal depression, four capillary planes that bear a precise relationship to the neuronal organization appear in a specific sequence with increasing eccentricity. the first plane to be established is the domina ... | 1990 | 2376631 |
| compensation of vertical vestibulo-ocular functions in squirrel monkeys after unilateral labyrinthectomy. | modifications in the vertical vestibulo-ocular reflex (vvor) were studied in four squirrel monkeys (saimiri sciureus) over time after unilateral labyrinthectomy. in the dark, with head upright, animals were exposed to sinusoidal rotation in the pitch plane. the magnetic field-pericorneal search coli technique was used to detect eye movement. the upward and downward slow-phase eye velocity (spev) of the vvor and the maximum spev of the vertical component of spontaneous nystagmus (spn) were studie ... | 1990 | 2382784 |
| ethanol effects on eeg spectra in monkeys: comparison to morphine and diazepam. | the effects of oral administration of 3 doses of ethanol (0.75, 1.0 and 1.5 g/kg) and single doses of morphine (2.5 mg/kg) and diazepam (2.5 mg/kg) on spectral components of the eeg were investigated in the squirrel monkey saimiri sciureus. comparisons of mean spectral power in the 4 frequency bands (2-4 hz, 4-8 hz, 8-16 hz, 16-32 hz) revealed that the lowest dose of ethanol (0.75 g/kg) produced some increase in power in all 4 frequency bands with significant increases in the 8-16 hz band. morph ... | 1987 | 2434316 |
| trypanosoma cruzi and trypanosoma rangeli in saimiri sciureus from bolivia and saguinus mistax from brazil. | examination of blood films for trypanosomes in primates housed at the tulane university delta regional primate research center showed that 47% (32/68) of the bolivian saimiri sciureus and 51% (68/135) of brazilian saguinus mistax harbored one or more types: trypanosoma (schizotrypanum) cruzi in 6% to 7% and trypanosoma (herpetosoma) spp. or trypanosoma (megatrypanum) spp. in 39% and 45%, respectively. trypanosomes were isolated from a sample of the infected monkeys and morphobiological studies w ... | 1986 | 3082228 |
| involvement of monoamine oxidase enzymes in the action of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine, a selective neurotoxin, in the squirrel monkey: binding and biochemical studies. | 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (mptp) is a new neurotoxin that causes degeneration of the dopaminergic nigrostriatal neurons and induces a parkinson-like state in several species, including humans and monkeys. the present study was designed to better characterize the properties of [3h]mptp binding sites and to evaluate the interaction of mptp with the oxidation of dopamine by monoamine oxidase (mao) in an animal species (saimiri sciureus) shown to be lesioned by mptp. our data conf ... | 1986 | 3089539 |
| cytomorphology of the area striata in saimiri sciureus. a golgi study. | nissl- and golgi preparations of the brain of the new world monkey saimiri sciureus were used to determine neuronal cell types and their distribution in the primary visual cortex (area striata or area 17). the visual cortex is located occipitally, mainly constituting the cortical surface around the calcarine fissure with six different laminae (total thickness about 1,300 micron). as the prevailing cell types, spiny neurons, such as pyramids and pyramid-like cells, many spiny multipolar cells, gi ... | 1988 | 2457048 |
| postnatal changes of igg and igm levels in squirrel monkeys (saimiri sciureus). | serum igg and igm levels were measured in domestically bred squirrel monkeys (saimiri sciureus) ranging in age from 0 days to 42 months, as well as in adult squirrel monkeys from the wild estimated to be 60 months or older. the results indicated that the transplacental transfer of igg occurs in the squirrel monkey but the transferability is lower in the squirrel monkey than in the cynomolgus monkey. immune response in the squirrel monkey occurs just after birth, as shown by igm production. | 1986 | 3100807 |
| dissociated response of plasma albumin and transferrin to protein-calorie restriction in squirrel monkeys (saimiri sciureus). | the responses of albumin and transferrin to selective nutritional interventions were assessed in 31 infant monkeys. diets were restricted in protein, calories, or both from age 2 to 8 wk (study a) or protein alone from age 4 to 24 wk (study b)--in both cases to prevent growth. transferrin levels in study a were significantly lower than control in all three restricted groups whereas albumin levels were decreased only in both low-protein groups. in study b albumin and transferrin concentrations we ... | 1987 | 3120570 |
| nervus terminalis, olfactory nerve, and optic nerve representation of luteinizing hormone-releasing hormone in primates. | the luteinizing hormone-releasing hormone (lhrh) system was examined immunocytochemically in olfactory bulbs of adult monkeys, including two new world species (squirrel monkey, saimiri sciureus and owl monkey, aotus trivirgatus) and one old world species (cynomolgus macaque, macaca fasciculata), and in the brain and nasal region of a fetal rhesus macaque macaca mulatta. lhrh neurons and fibers were found sparsely distributed in the olfactory bulbs in all adult monkeys. there was more lhrh in the ... | 1987 | 3129973 |
| on the a. malaris of the common squirrel monkey (saimiri sciureus). | detailed observations were made of the a. malaris in 11 adult common squirrel monkeys (saimiri sciureus) utilizing the plastic injection method. the malar artery was well-developed in all 21 examples observed and arose medially from the infraorbital artery proximal to the entrance of the infraorbital canal and lateral to the obliquus inferior muscle. the a. malaris passed superomedially outside the periorbita on the orbital surface of the maxilla and curved medially in front of the muscle, where ... | 1989 | 2812675 |
| the distribution of somatostatin-like immunoreactivity in the monkey hippocampal formation. | the distribution of somatostatin-like immunoreactivity was studied in the hippocampal formation of the old world (macaca fascicularis) and new world (saimiri sciureus) monkeys. series of coronal sections were processed by the unlabeled second antiserum method using primary antisera which recognize somatostatin-28 (s309) or somatostatin-28(1-12) (s320). neuronal cell bodies were more readily stained with antiserum s309 and were observed throughout the hippocampal formation. the most prominent acc ... | 1985 | 2865277 |
| refractoriness of callithrix penicillata red blood cells to plasmodium falciparum in vivo and in vitro. | attempts to infect the new world marmot callithrix penicillata with plasmodium falciparum were unsuccessful. attempts were also made to infect red blood cells of c. penicillata and saimiri sciureus with p. falciparum in vitro, and these too were unsuccessful due to a high rate of hemolysis produced by apparently adverse culture conditions. it is concluded that modifications to the existing culture conditions will need to be made before successful parasitemia can be induced in vitro in simian ery ... | 1988 | 3132548 |
| characterization of colonic cellular glycoconjugates in colitis and cancer-prone tamarins versus colitis and cancer-resistant primates. | differences in colonic secretory glycoconjugates (ie, mucin) between normal and ulcerative colitis-prone patients have been noted. similar differences may occur in a corresponding primate model, the cotton-top tamarin (ctt), saguinus oedipus, a new world monkey which suffers from spontaneous chronic colitis and colon cancer. lectin reagents were used to characterize and compare colonic cell surface, cytoplasmic, and secretory glycoconjugates of 9 clinically healthy cotton-top tamarins, 7 colitis ... | 1988 | 3132857 |
| neuropeptide y-immunoreactive neurons in the striatum of cat and monkey: morphological characteristics, intrinsic organization and co-localization with somatostatin. | a detailed study of the distribution of neuropeptide y (npy) in the striatum of squirrel monkey (saimiri sciureus) and cat was undertaken by means of indirect immunofluorescence and peroxidase-antiperoxidase (pap) methods. in monkey, the npy-immunoreactivity is homogeneously distributed along the entire extent of the caudate nucleus (cd) and putamen (put), while in cat marked heterogeneities are noted. in the cd of cat, the npy-immunoreactive fibers and cell bodies are concentrated in numerous p ... | 1986 | 2871900 |
| an immunohistochemical characterization of somatostatin-28 and somatostatin-281-12 in monkey prefrontal cortex. | the distribution of the prosomatostatin-derived peptides (psdp) somatostatin-28 (ss-28) and somatostatin-281-12 (ss-281-12) was characterized immunohistochemically in the prefrontal cortical regions of both old world cynomolgus monkeys (macaca fascicularis) and new world squirrel monkeys (saimiri sciureus). comparison of staining with antisera specific for each peptide revealed that these antigens were segregated within immunoreactive neurons such that ss-28 was largely confined to the perinucle ... | 1986 | 2873154 |
| a comparative study on the elicitability of vocalization by electrical brain stimulation, glutamate, aspartate and quisqualate in the squirrel monkey. | in 6 squirrel monkeys (saimiri sciureus), 71 brain sites yielding vocalization when electrically stimulated were tested for their capability to produce vocalization when injected with l-glutamate (glu), n-methyl-d-aspartate (nmda) and quisqualate. out of the 71 sites, only 3 reacted positively to glu, 4 to quisqualate and 7 to nmda. two of the quisqualate-positive sites reacted also to nmda and one to glu. the positive sites were located at the border between the substantia innominata and globus ... | 1986 | 2873531 |
| experimental infections of simians with human malaria: attempts to infect callithrix penicillata with plasmodium falciparum. | after reviewing the use of non-human primates of the old and new worlds for human malaria research, we concluded that another experimental animal which is easily available to use and possible to rear indoors is needed. thus, we studied the susceptibility of the marmoset callithrix penicillata to plasmodium falciparum erythrocytic infections. the marmosets received various p. falciparum human isolates, directly from a patient and from continuous cultures. the palo alto strain, which has been adap ... | 1987 | 3149726 |
| effect of human gamma interferon on yellow fever virus infection. | we studied yellow fever virus infection in two species of monkey: saimiri sciureus (squirrel monkeys) and macaca mulatta (rhesus monkeys). human gamma interferon was administered intravenously in five equal doses, one was given 24 hr before infection followed by four doses 24 hr apart. interferon reduced the levels and duration of viremia and the severity of hepatitis in squirrel monkeys. interferon prolonged survival time and delayed the appearance of viremia and hepatitis in infected rhesus mo ... | 1988 | 3152785 |
| differential dopaminergic innervation of the two pallidal segments in the squirrel monkey (saimiri sciureus). | immunohistochemical studies with an antiserum raised against tyrosine hydroxylase have allowed us to demonstrate a dense dopaminergic innervation of the globus pallidus in the squirrel monkey. this innervation derived mostly from two fascicles that detached themselves from the major ascending dopaminergic bundle arising from midbrain dopamine cell bodies and running in the lateral hypothalamus. dopaminergic fibers reached the globus pallidus by coursing along its two major output pathways: the l ... | 1987 | 2891410 |
| efficacy of ivermectin against natural infection of strongyloides spp. in squirrel monkeys (saimiri sciureus). | | 1988 | 3184861 |
| elevation in plasma glucagon levels in response to stress in squirrel monkeys: comparisons of two subspecies (saimiri sciureus boliviensis and saimiri sciureus sciureus). | bolivian (bo) and brazilian (br) squirrel monkeys (sms) were captured and restrained to determine patterns of glucagon and glucose response. in both subspecies, plasma glucagon and glucose levels rose rapidly in response to restraint procedures; glucagon levels in brsms and glucose levels in both subspecies returned to basal values in 15 minutes. the magnitude of the glucagon and glucose responses differed significantly between bosms and brsms. | 1988 | 3193450 |
| the dopaminergic innervation of monkey prefrontal cortex: a tyrosine hydroxylase immunohistochemical study. | the distribution of tyrosine hydroxylase (th)-immunoreactive fibers was characterized immunohistochemically in the prefrontal cortical regions of both old world cynomolgus monkeys (macaca fascicularis) and new world squirrel monkeys (saimiri sciureus). in both species, differences in the density and/or laminar distribution of th-labeled fibers were detected both across and within almost every prefrontal cytoarchitectonic region. in cynomolgus monkeys, areas 9 and 24 had the greatest density of t ... | 1988 | 2899447 |
| nocturnal vocalizations by squirrel monkeys (saimiri sciureus). | | 1988 | 3254847 |
| location of respiratory motoneurons involved in phonation. an hrp study in the squirrel monkey. | in 11 squirrel monkeys (saimiri sciureus) the motoneuronal distribution of those muscles being involved in the respiratory component of phonation, that is the mm. obliquus externus and internus, rectus and transversus abdominis, intercostalis externus and internus, and intercartilagineus, were studied with the horseradish peroxidase retrograde tracing technique. it was found that the spinal representations of the abdominal muscles overlap to a large extent. motoneurons of all four abdominal musc ... | 1989 | 2607132 |
| neurons of the subthalamic nucleus in primates display glutamate but not gaba immunoreactivity. | immunohistochemical studies undertaken with a highly specific antiserum raised against gamma-aminobutyric acid (gaba)-glutaraldehyde-lysyl-protein conjugate showed that cell bodies of the subthalamic nucleus in the squirrel monkey (saimiri sciureus) were closely surrounded by several gaba-positive terminals but were not themselves immunoreactive. in contrast, after incubation with a monoclonal antibody directed against carbodiimide-fixed glutamate, virtually all cell bodies of the subthalamic nu ... | 1988 | 2900056 |
| glomerulopathy in squirrel monkeys with acute plasmodium falciparum infection. | the renal pathology of 9 squirrel monkeys (saimiri sciureus) with acute plasmodium falciparum infection was studied by light and electron microscopy. endocapillary proliferative glomerulonephritis was the major pathological change observed. the peroxidase anti-peroxidase method demonstrated the presence of igg, igm, and p. falciparum antigens in the mesangium and basement membrane. these findings were consistent with those seen in humans with acute p. falciparum infection and indicates that squi ... | 1988 | 3277466 |
| sporozoite-induced infections of the salvador i strain of plasmodium vivax in saimiri sciureus boliviensis monkeys. | twenty saimiri sciureus boliviensis monkeys from bolivia were inoculated intravenously with sporozoites of the salvador i strain of plasmodium vivax. all animals were splenectomized 7 days after inoculation. inoculation of 100,000 sporozoites resulted in prepatent periods averaging 16.6 days; all monkeys developed high-level parasitemias with an average maximum of 103,000 per mm3. inoculation of 10,000 sporozoites resulted in average prepatent periods of 19.4 days; one of the resulting infection ... | 1988 | 3294366 |
| effect of varying dosages and adjuvants on antibody response in squirrel monkeys (saimiri sciureus) immunized with the porcine zona pellucida mr = 55,000 glycoprotein (zp3). | using the porcine zona pellucida mr = 55,000 (zp3) glycoprotein as immunogen, the effect of varying zp3 dosages (50 micrograms, 25 micrograms, 5 micrograms) or adjuvants (200 micrograms zp3 with either freund's, a1[oh]3, or a muramyl dipeptide analog [mdp] on antibody response was evaluated in female squirrel monkeys. although the dosage range investigated did result in dose-dependent titration profiles, antisera from all dosage groups demonstrated in vitro contraceptive potential. mdp was as ef ... | 1989 | 2619883 |
| study of some parameters affecting the in vitro cultivation of plasmodium falciparum within saïmiri sciureus red blood cells. | the in vitro growth and multiplication of the erythrocytic stages of plasmodium falciparum within saïmiri sciureus (squirrel monkey) red blood cells have been studied. various parameters, such as the origin of the red blood cells and serum supplement, nature of the buffer, influence of the final ph of the medium, role of proteose peptone and glucose addition, were investigated. the selection of the best culture conditions led to the obtention of a reproducible in vitro growth of two parasite cyc ... | 1986 | 3295467 |
| pathologic changes associated with fatal plasmodium falciparum infection in the bolivian squirrel monkey (saimiri sciureus boliviensis). | fatal cases of experimental plasmodium falciparum (indochina i) in bolivian squirrel monkeys (saimiri sciureus boliviensis) were examined by histologic and ultrastructural methods. gross lesions were characterized by hepatosplenomegaly and interstitial pulmonary changes. histologically, there was marked diffuse reticuloendothelial hyperplasia, pulmonary alveolar septal thickening, mesangioproliferative glomerulonephropathy, sequestration of parasitized erythrocytes in deep vascular beds, degener ... | 1987 | 3300388 |
| peripheral blood mononuclear cells in the squirrel monkey saimiri sciureus: characterization and functional aspects of t lymphocytes. | characterization and functional aspects of squirrel monkey peripheral blood mononuclear cells (pbmc), and mainly t cells, are described in the present paper; this should enable the study of cellular immune responses in an experimental model for malaria. pbmc were obtained from ficoll-hypaque gradient separation and fractionated into t cells and non-t cells by means of e-rosetting techniques and adherence to plastic dishes. pbmc subset phenotypes were characterized by means of monoclonal antibodi ... | 1989 | 2629039 |
| open-loop and closed-loop optokinetic nystagmus in squirrel monkeys (saimiri sciureus) and in man. | horizontal optokinetic nystagmus (okn) was measured in 3 normal squirrel monkeys by means of the electromagnetic search coil technique. binocular and monocular stimulation of each eye to the left and right by moving vertical stripe patterns of 2.37 or 15 degree period were applied at angular velocities of 0.5 to 400 deg/s. after measurement of horizontal okn under normal conditions, open-loop okn gain was determined by monocular stimulation of an eyeball immobilized by means of retrobulbar injec ... | 1989 | 2699364 |
| anatomical connections of the prepositus and abducens nuclei in the squirrel monkey. | the primary goal of this investigation was to identify the areas of the brainstem and cerebellum that provide afferent projections to the nucleus prepositus hypoglossi in primates. after horseradish peroxidase conjugated to wheat germ agglutinin (wga-hrp) was injected into the prepositus in squirrel monkeys (saimiri sciureus), the largest populations of retrogradely labeled neurons were found in the vestibular nuclei, the contralateral perihypoglossal nuclei, and the medullary and pontine reticu ... | 1988 | 3346381 |
| the nasotemporal division in primate retina: the neural bases of macular sparing and splitting. | in primates, each hemisphere contains a representation of the contralateral visual hemifield; unilateral damage to the visual pathways results in loss of vision in half of the visual field. apparently similar severe, unilateral lesions to the central visual pathways can result in two qualitatively different central visual field defects termed macular sparing and macular splitting. in macular sparing a 2 degrees to 3 degrees region around the fovea is spared from the effects of unilateral damage ... | 1988 | 3353708 |
| transmission of the os strain of plasmodium inui to saimiri sciureus boliviensis and aotus azarae boliviensis monkeys by anopheles dirus mosquitoes. | eight saimiri and 7 aotus monkeys were exposed to infection with the os strain of plasmodium inui via the bites of from 2 to 7 anopheles dirus mosquitoes. all saimiri monkeys developed high-level infections of from 152,000 to 500,000/mm3 after prepatent periods of from 14 to 17 days. only 1 aotus monkey developed a patent infection after a period of 28 days. feeding on these animals failed to result in infection of an. dirus mosquitoes. | 1988 | 3379532 |
| plasma lipoprotein alterations in squirrel monkeys (saimiri sciureus) during ethanol administration and abstinence. | the time course of lipoprotein changes during ethanol (etoh) consumption followed by abstinence was examined in 3 groups of male squirrel monkeys: 1) controls fed isocaloric liquid diet; 2) low etoh monkeys given liquid diet with vodka substituted isocalorically for carbohydrate at 12% of calories; and 3) high etoh animals fed diet plus vodka at 24% of calories. after 2 weeks, high etoh monkeys showed significant elevations in total plasma cholesterol which continued to increase at 4 weeks and t ... | 1988 | 3401294 |
| noradrenergic innervation of monkey prefrontal cortex: a dopamine-beta-hydroxylase immunohistochemical study. | norepinephrine has been implicated in the regulation of a number of cortical functions, yet relatively little is known about the anatomical organization of noradrenergic axons in the expanded and highly differentiated prefrontal cortex of primates. in this study, the distribution of fibers containing dopamine-beta-hydroxylase (dbh), the enzyme that converts dopamine to norepinephrine, was characterized immunohistochemically in the prefrontal cortical regions of old world cynomolgus monkeys (maca ... | 1989 | 2715385 |
| sustained azoospermia in squirrel monkey, saimiri sciureus, resulting from a single intratesticular glycerol injection. | previous studies in rats had shown that a single intratesticular injection of glycerol resulted in long-term suppression of spermatogenesis without marked alterations in hormone levels. studies were undertaken to determine the effect of similar treatment in squirrel monkeys (saimiri sciureus). ten monkeys received an intratesticular injection of saline (controls) and ten of glycerol solution (treated). semen and blood samples were obtained on a weekly or bi-weekly basis one month prior to, durin ... | 1989 | 2721196 |
| a two-site sandwich immunoradiometric assay of squirrel monkey (saimiri sciureus) igm using monoclonal antibodies. | nine hybrid clones secreting antibodies to squirrel monkey (saimiri sciureus) igm were produced and two of these (1f1g5 and 5h11b3) were selected for further studies. these non-precipitating monoclonal antibodies reacted with two distinct repetitive antigenic determinants, probably of the conformational type, only present on the native or sds-denatured igm molecule. reduction of the pentamer with 2-mercaptoethanol led to complete destruction of the corresponding epitopes. 1f1g5 antibodies from a ... | 1989 | 2926146 |