| [hemiparkinsonism, probably due to malaria (author's transl)]. | | 1978 | 348371 |
| development of an immunoenzymatic assay using a monoclonal antibody against a 50-kda catabolite from the p126 plasmodium falciparum protein to the diagnosis of malaria infection. | the who criterion of defering any donation of blood by a confirmed case of malaria for three years after cessation of therapy can not be applied in areas where malaria is endemic. for this reason we developed an immunoenzymatic assay for the detection of plasmodial antigens for blood screening in malarial endemic areas. so, we tested sera from 191 individuals. among patients with active disease 100% of the cases of plasmodium falciparum or mixed infections and 91.7% of those with p. vivax were p ... | 1992 | 1343689 |
| the role of cytokines in plasmodium vivax malaria. | the cytokine tumor necrosis factor and other as yet unidentified factor(s) which together mediate the killing of intraerythrocytic malaria parasites are transiently elevated in sera during paroxysms in human plasmodium vivax infections in non-immunes. these factors which included tnf and parasite killing factor(s) are associated with the clinical disease in malaria to the extent that their transient presence in infection sera coincided with paroxysms, the the most pronounced clinical disturbance ... | 1992 | 1343726 |
| clinical and hematologic peculiarities of malaria in infancy. a study of 40 infants. | | 1978 | 346290 |
| evaluation of indirect immunofluorescent antibody test for detection of igm specific antibodies in malaria. | indirect immunofluorescent antibody test using plasmodium falciparum antigen from in vitro culture was evaluated for detecting igm antibodies in order to determine the feasibility of its application in serodiagnosis of malaria. test was compared with the already adapted igg-iif test using the same antigen. it was found that none of the healthy controls and slide negative fever cases had malaria igm antibodies whereas 8 per cent of healthy controls and 49.01 per cent of the slide negative fever c ... | 1992 | 1344176 |
| detection of malaria antigen in blood by inhibition elisa. | demonstration of parasite associated antigen in blood by inhibition elisa in malaria patients and controls is described. the test was negative in all the healthy controls and positive in 90 per cent of the plasmodium vivax malaria cases. the test was found to be quite sensitive, being able to detect 5 parasites/10(6) rbc in a case of natural p. falciparum infection. there was 95.3 per cent agreement between the results of this test and igm-iif test. | 1992 | 1344943 |
| tumour necrosis factor-dependent parasite-killing effects during paroxysms in non-immune plasmodium vivax malaria patients. | plasmodium vivax malaria infections in non-immune individuals manifest as periodic clinical episodes of fever with chills and rigors known as paroxysms. we have demonstrated that in non-immune patients the period of paroxysm is associated with the transient presence of plasma factors which kill gametocytes, the intra-erythrocytic sexual stages of the malaria parasite which transmit the infection from humans to mosquito, rendering them non-infectious to mosquitoes. gametocyte killing in paroxysm ... | 1992 | 1351432 |
| treatment of primaquine-resistant plasmodium vivax malaria. | | 1992 | 1353224 |
| comparison of oral artemether and mefloquine in acute uncomplicated falciparum malaria. | plasmodium falciparum malaria in thailand is highly resistant to available antimalarials, and alternative drugs are needed urgently. artemether is effective against falciparum malaria but associated with a high recrudescence rate. the proper dosage regimen remains to be defined. we have done a clinical trial comparing mefloquine 1250 mg in divided doses with oral artemether at 700 mg total dose given over 5 days in acute uncomplicated falciparum malaria. 46 patients, admitted to the bangkok hosp ... | 1992 | 1359318 |
| plasmodicidal effect of desferrioxamine b in human vivax or falciparum malaria from thailand. | desferrioxamine b (dfo, desferal), an iron chelator, was earlier shown to be active against plasmodium falciparum in vitro and in vivo. the present open pilot study served to assess its clinical tolerability and efficacy in human malaria under hospital conditions. continuous intravenous dfo was administered to 28 thai males at a dose of 100 mg/kg over 24 h for 3 consecutive days. no other antimalarial therapy was administered unless recrudescence had occurred. the first 14 patients had symptomat ... | 1992 | 1359761 |
| "pseudo-resistant" malaria in tropical countries. | | 1992 | 1360133 |
| [imported malaria in a tropical unit in paris. about 100 cases (author's transl)]. | from a hundred cases of imported malaria observed in paris, the authors emphasize the following points: annual increase of cases, lack or inadequacy of prophylaxis, frequent reinfestations among black africans living in france, and comming back in endemic area for a brief journey, high risks for pregnant women. | 1979 | 395872 |
| [erythrocyte blood groups and geographic pathology (author's transl)]. | blood groups are an obstacle to reproduction, transfusion and transplantation. there are immunological abortions due to the antibodies of "p" phenotype women; and rh haemolytic disease of the new-born is in direct proportion to the frequency of the "r" gene in a given population; the problem of transfusional allo-immunisation is completely parallel. certain membrane anomalies (due to exceptional erythrocyte blood groups--rh null, rh mod or mcleod, for example), can provoke hemolytic anaemias, bu ... | 1979 | 400037 |
| immunobiology of malaria. | malaria, the number one disease in the world, is caused by intracellular protozoans belonging to the subphylum, sporozoa; suborder, haemosphoridia; and family, plasmodiidae. the four classical organisms producing disease in man are plasmodium vivax, p. falciparum, p. malariae, and p. ovale. although malaria has been known to man for centuries, attempts are still being made to control and eliminate its devastating effects in tropical and subtropical areas of the world. current active interest in ... | 1979 | 439167 |
| the treatment of malaria. | at least four doses of quinine followed by a single dose of mefloquine or by a single dose of sulfadoxine-pyrimethamine are two highly effective regimens for chloroquine-resistant falciparum malaria. mefloquine alone is valuable in ambulant patients. chloroquine-sensitive falciparum malaria can be treated with a course of chloroquine. vivax and all other types of malaria should be treated with sequential chloroquine and primaquine. quinine, by intravenous infusion, is the most effective drug for ... | 1976 | 764937 |
| jaundice and hepatomegaly in malaria. | | 1975 | 770013 |
| observations on malaria in indonesian timor. | malaria parasitemias were found in 35% of 520 individuals from a village in timor, indonesia. plasmodium falciparum accounted for 80% of infections. the existence of p. ovale in timor is reported for the first time. the who standard field test for drug resistance did not reveal significant resistance of p. falciparum or p. vivax to chloroquine. | 1975 | 1098490 |
| fatal falciparum malaria among narcotic injectors. | eleven narcotic injectors from a prison in saigon were hospitalized with falciparum malaria. coma and intense parasitemia were common and eight patients died soon after admission. two of three autopsied cases also had purulent pulmonary infections. no non-addicted prisoners were hospitalized for malaria. nine more unsuspected falciparum infections were found among 29 other addicts in the prison. the clustering of malaria infections among narcotic injectors who had not been in malarious areas ind ... | 1975 | 1103639 |
| prevalence and level of antibodies to the circumsporozoite proteins of human malaria parasites, including a variant of plasmodium vivax, in the population of two epidemiologically distinct areas in the state of acre, brazil. | a seroepidemiological study of the prevalence of antibodies against the repeating epitopes of circumsporozoite (cs) proteins of human malaria parasites was conducted in 2 different areas in the state of acre, brazil in 1987 and 1990. in 1987 antibodies against the cs protein of the vk 247 variant plasmodium vivax as well as antibodies against the cs proteins of p. falciparum and the classic p. vivax were found at relatively high rates in the 2 areas, but significant microepidemiological differen ... | 1992 | 1373529 |
| human recognition of t cell epitopes on the plasmodium vivax circumsporozoite protein. | in order to identify t cell epitopes recognized by human in the plasmodium vivax circumsporozoite protein, 28 overlapping synthetic peptides spanning the entire circumsporozoite protein were tested for their ability to stimulate proliferation of pbmc from 22 adults living in a malaria-endemic area of the colombian pacific coast and from four individuals who never had a history of malaria infection. in addition, balb/c mice were immunized with pools of peptides, and their lymph node cells were st ... | 1992 | 1376347 |
| comparison of the complement fixation, indirect immunofluorescence, and indirect hemagglutination tests for malaria. | the complement fixation (cf), indirect immunofluorescence (iif), and indirect hemagglutination (iha)tests for malaria were compared by using sera from u.s. citizens with either natural infections or heroin-associated, needle-induced infections. in natural plasmodium vivax infections, the cf, iif, and iha tests apparently detect malarial antibodies equally efficiently for the first 2 months after the onset of symptoms, but the titers obtained by cf and iif rapidly decline within a year, while the ... | 1975 | 1103641 |
| [ultrastructure of erythrocytic stage of plasmodium vivax in humans]. | after the merozoite entered the erythrocyte, the membrane debris in the parasitophorous vacuoles of early ring form was passed out through a narrow external aperture in erythrocyte to the exterior. the trophozoite was oval or irregular in shape. ingestion of host cell cytoplasm occurred cystostomally. the asexual parasite possessed cristate mitochondria and was surrounded by a single-membraned pellicle. the gametocyte possessed cristate mitochondria and was surrounded by two unit membranes. the ... | 1992 | 1394907 |
| genetic red cell defects and malaria. | | 1992 | 1398816 |
| development and evaluation of an enzyme-linked immunosorbent assay for plasmodium vivax-vk247 sporozoites. | an enzyme-linked immunosorbent assay (elisa) for the plasmodium vivax-vk247 (variant) circumsporozoite (cs) protein was developed and evaluated using sporozoites produced by feeding mosquitoes on thai patients with parasitologically confirmed p. vivax infections. the elisa had a detection threshold of fewer than 50 sporozoites. using this assay in conjunction with an elisa for the vk210 polymorph, nearly 16% of the 235 p. vivax cases produced sporozoites positive only for the variant; 69% produc ... | 1992 | 1404266 |
| polymorphism in the circumsporozoite protein of the human malaria parasite plasmodium vivax. | the circumsporozoite (cs) protein that covers the surface of infectious sporozoites is a candidate antigen in malaria vaccine development. to determine the extent of b- and t-epitope polymorphism and to understand the mechanisms of antigenic variability, we have characterized the cs protein gene of plasmodium vivax from field isolates representing geographically distant regions of papua new guinea (png) and brazil. in the central repeat region of the cs protein, in addition to variation in the n ... | 1992 | 1279418 |
| high seasonal malaria transmission rates in the intermediate rainfall zone of sri lanka. | malaria transmission was studied at nikawehera, a long-established farming village, located in the intermediate rainfall zone of sri lanka. observations were made over a 12-month period (october-september) that included the main rainy season which occurred during the north-east monsoon in november-january. anolpheles culicifacies, the recognized vector of malaria in sri lanka, was the predominant anopheline mosquito collected by human night baiting at nikawehera. high entomological inoculation r ... | 1992 | 1304700 |
| [rapid diagnosis of malaria. the microwave furnace]. | thick blood is a well known method for malaria diagnosis, very faithful and sensitive, but it could not be used in emergency because it had to dry for many hours. micro-wave over allows a quick drying (two minutes). do it can now be used in emergency. | 1992 | 1422273 |
| muramyl peptide adjuvants for plasmodium falciparum and plasmodium vivax circumsporozoite vaccines in rodent model systems. | circumsporozoite proteins from the malaria parasites plasmodium falciparum and plasmodium vivax were expressed at high levels in the yeast saccharomyces cerevisiae. recombinant proteins varied both in length and in number of the natural amino acid repeat motifs. the proteins were purified and used to immunize mice, guinea pigs, and rabbits. novel muramyl peptide adjuvants were used that increased the immune response as measured by elisa assays, indirect immunofluorescence of fixed sporozoites, a ... | 1992 | 1305890 |
| [the importation of malaria from afghanistan into the ussr (a retrospective analysis of data from epidemiological surveys of cases and foci during 1981-1990)]. | a retrospective analysis of imported malaria due to military operations revealed the main regularities in the behaviour of plasmodium vivax population and the relationships between the imported parasite and the native anopheles species. high percentage of cases with protracted incubation was noted in soldiers after their home-coming; the clinical symptoms were often registered 7-12 months after return. no epidemic consequence of imported and introduced cases of tertian malaria in malariogenic ar ... | 1992 | 1435550 |
| infection of anopheles darlingi fed on patients infected with plasmodium vivax before and during treatment with chloroquine plus primaquine in costa marques, rondönia, brazil. | five patients with asexual and sexual parasites of plasmodium vivax were treated orally with 600 mg chloroquine diphosphate (hour 0) followed with 300 mg at 8, 24 and 48 h later. primaquine phosphate, 15 mg, was administered concurrently at h 0 and at 24 h intervals for 14 days. anopheles darlingi were fed before the first dose (h -0.5) and 0.5, 1, 2, 4, 6, 8, 10, 12, 16, 20, 24, 36, 48, 60 and 72 h later. mosquitoes were examined for oocysts on day 8 and for sporozoites on day 15 after infectio ... | 1992 | 1308564 |
| chemoprophylaxis against malaria in papua new guinea: a trial of amodiaquine and a combination of dapsone and pyrimethamine. | a placebo-controlled chemoprophylaxis trial was carried out in 1980 in 318 semi-immune school children in the madang area of papua new guinea, where there was a high prevalence of strains of plasmodium falciparum resistant to 4-aminoquinolines. since prophylaxis with amodiaquine at 5 mg/kg weekly had failed, amodiaquine at a dose of 10mg/kg weekly and maloprim (half a tablet or one tablet depending on body weight, which gave ranges of dapsone of 1.7-3.3mg/kg and pyrimethamine 0.2-0.4 mg/kg) week ... | 1992 | 1341089 |
| modern immunological approaches to assess malaria transmission and immunity and to diagnose plasmodial infection. | the present paper reviews our recent data concerning the use of immunological methods employing monoclonal antibodies and synthetic peptides to study malaria transmission and immunity and to diagnose plasmodial infection. as concerns malaria transmission, we studied the main vectors of human malaria and the plasmodial species transmitted in endemic areas of rondônia state, brazil. the natural infection of anopheline was evaluated by immunoradiometric assay (irma) using monoclonal antibodies to a ... | 1992 | 1342707 |
| use of glass beads and cf 11 cellulose for removal of leukocytes from malaria-infected human blood in field settings. | passage of malaria-infected blood through a two-layered column composed of acid-washed glass beads and cf 11 cellulose removes white cells from parasitized blood. however, because use of glass beads and cf 11 cellulose requires filtration of infected blood separately through these two resins and the addition of adp, the procedure is time-consuming and may be inappropriate for use in the field, especially when large numbers of blood samples are to be treated. our modification of this process yiel ... | 1992 | 1343674 |
| field evaluation of an enzyme-linked immunosorbent assay for estimating the sporozoite rate in anopheles albimanus. | we have verified for specimens of anopheles albimanus that an enzyme-linked immunosorbent assay (elisa) used to assess plasmodium vivax and p. falciparum sporozoite antigen rates gives results comparable to the salivary gland dissection method for estimating sporozoite rates. for 14,150 adults of an. albimanus, captured at five locations in guatemala, we report sporozoite antigen rates of 0.03-0.57%, which correlate with the malaria prevalences at the study sites. we also present data that sugge ... | 1992 | 1443346 |
| human igg responses against the n-terminal region of the merozoite surface protein 1 of plasmodium vivax. | the complete primary structure of the gene encoding the merozoite surface protein 1 of plasmodium vivax (pvmsp-1) revealed the existence of interspecies conserved regions among the analogous proteins of other plasmodia species. here, three dna recombinant clones expressing 50, 200 and 500 amino acids from the n-terminal region of the pvmsp-1 protein were used on elisa and protein immunoblotting assays to look at the igg antibody responses of malaria patients from the brazilian amazon region of r ... | 1992 | 1343729 |
| imported malaria in the bronx: review of 51 cases recorded from 1986 to 1991. | the cases of 51 patients with malaria seen at the albert einstein college of medicine hospitals from january 1986 to june 1991 are reviewed. thirty-five patients acquired infection on journeys to their country of origin. of these 35 patients, 83% of whom had lived in the united states for > or = 2 years, only 17% received antimalarial prophylaxis. ten of the 51 patients were born and raised in the united states, and 70% received prophylaxis (p < .01). six of the 51 patients were visitors to the ... | 1992 | 1445975 |
| chloroquine-resistant plasmodium vivax: it may be a common problem. | | 1992 | 1448003 |
| malaria entomological inoculation rates in western venezuela. | over 61,000 anophelines collected between january 1988 and october 1989 in three villages in western venezuela were assayed by elisa for plasmodium vivax circumsporozoite (cs) protein. the six specimens confirmed positive belonged to three species: anopheles (nyssorhynchus) nuneztovari gabaldón, 1940, a. albitarsis arribalzaga, 1878 sensu lato and a. oswaldoi (peryassu, 1922). the estimated cs protein rate for all species combined was 0.01% (95% confidence limits 0.004-0.02%). this cs protein ra ... | 1992 | 1363181 |
| cerebral symptoms with p. vivax malaria. | | 1992 | 1452322 |
| south american monkeys in the development and testing of malarial vaccines--a review. | south american aotus and saimiri monkeys, which are susceptible to infection with human malarias, have been used to develop models for the testing of human malaria vaccines. studies indicate that blood-stage and sporozoite vaccines can be tested in these monkeys using appropriate strains of parasites. | 1992 | 1364203 |
| overview: immunology of malaria and progress in malaria vaccine development. | | 1992 | 1364871 |
| acquired malaria--how early can it occur. | | 1992 | 1459693 |
| promiscuous malaria peptide epitope stimulates cd45ra t cells from peripheral blood of nonexposed donors. | pbl from individuals with no history of malaria exposure, as well as cord blood lymphocytes, were tested for proliferation to t cell epitopes from the malaria circumsporozoite proteins of plasmodium falciparum and plasmodium vivax. cells from many individuals proliferated in response to these peptides, but for two peptides (p. vivax317-336 and p. falciparum cs331-350) the response rate ranged from 64 to 93%, with the specific stimulation indices reaching as high as 38. the phenotype of the cells ... | 1992 | 1370523 |
| [concerning the article of sh.d. moshkovski "explanation of the difference between incubation type and the characteristics of alternation of acute periods of malaria caused by different strains of plasmodium vivax (med. parazitol., 1973, no. 4, pp. 394-400)]. | | 1976 | 799234 |
| immunization of man against falciparum and vivax malaria by use of attenuated sporozoites. | with strict adherence to ethical guidelines, a volunteer was immunized against sporozoites of plasmodium falciparum and p. vivax, the antigen consisting of attenuated sporozoites of each species inoculated through bites of mosquitoes x-irradiated at a minimum dosage of 15,000 rads. on one occasion this dosage did not render all p. vivax sporozoites noninfective. species specificity of antigen and antibody was demonstrated, but within each species a wide geographical diversity of strains proved i ... | 1975 | 808142 |
| identification of a cryptic intron in the plasmodium vivax duffy binding protein gene. | | 1992 | 1474997 |
| chloroquine-resistant plasmodium vivax in brazil. | | 1992 | 1475838 |
| chloroquine-resistant plasmodium vivax in brazil. | | 1992 | 1475839 |
| chloroquine-resistant plasmodium vivax in brazil. | | 1992 | 1475840 |
| prolonged in vitro cultivation of plasmodium vivax using trager's continuous-flow method. | | 1992 | 1480609 |
| malariometric survey in keoudom district, laos: sensitivity of plasmodium falciparum to anti-malarials and automedication with chloroquine. | a malariometric survey was conducted in the keoudom district, in the northern part of vientiane province, laos, where an artificial dam-lake on the nam river is located. the parasite rate of the whole cohort representing 1,105 subjects was 2.44% with the predominance of plasmodium vivax (70%), while p. falciparum represented 30% with the average parasite density index 3. the low spleen rate (2.3%) characterized the study area as a hypoendemic zone. ifat antibodies were examined in 419 subjects. ... | 1992 | 1488689 |
| on-site diagnosis of plasmodium falciparum, p. vivax, and p. malariae by using the quantitative buffy coat system. | the quantitative buffy coat (qbc) system was used for the detection and identification of malaria parasites in blood specimens from 570 residents of oksibil, an isolated highland valley in the eastern jayawijaya mountains of irian jaya (indonesian new guinea). the availability of a battery-powered centrifuge and a fiberoptic paralens enabled us to complete and interpret the assay in this remote environment. of 322 qbc tubes examined for 2-4 min each, results of 295 (92%) concurred with findings ... | 1992 | 1491313 |
| [chemotherapy and chemoprophylaxis of malaria (author's transl)]. | chloroquine and amodiaquine are demonstrably still the most reliable drugs for the treatment of malaria, except in the south east asia area, and in parts of south and central america where an altered sensitivity of falciparum plasmodia has been confirmed. the present position of malaria prophylaxis is, unfortunately, anything but satisfactory. but there are already some good preparations which, if correctly used with consideration of all available information, contribute considerably to the prev ... | 1976 | 822313 |
| letter: plasmodium vivax tissue stage in saguinus geoffroyi. | | 1976 | 822543 |
| random mating of natural plasmodium populations demonstrated from individual oocysts. | dna amplified from individual plasmodium vivax oocysts, produced by feeding mosquitoes directly on naturally infected humans in thailand, was used to study cross-mating of 2 polymorphs of the circumsporozoite (cs) gene, vk 210 and vk 247. alleles were detected in matched blood parasites, sporozoites, and individual oocysts with oligoprobes specific to characteristic repeat units. oocysts developing from 3 cases in which mixed alleles were present in the blood parasites had genotype frequencies, ... | 1992 | 1501632 |
| malaria complicating neoplastic disease. | two patients with neoplastic disease had transfusion-induced malaria. in a patient with acute myelogenous leukemia infected with plasmodium vivax, neither his underlying disease nor intensive cytotoxic chemotherapy appeared to ameliorate or worsen the clinical course of his infection. in a splenectomized patient with metastatic carcinoma of the colon, p malariae infection was associated with a fulminant course simulating cerebral malaria. despite delay in diagnosis, both patients responded drama ... | 1976 | 1065254 |
| letter: unexplained fever. | | 1975 | 1090330 |
| the prevalence and relationships of malaria, anemia, and malnutrition in a coastal area of el salvador. | to study the relationships between malaria, anemia and malnutrition, 853 school-age children from a high malaria incidence area and an adjacent low incidence area were surveyed in september 1972. for the high incidence area the malaria slide positivity rate was 3.5%, spleen rate 7.6% and malaria (indirect fluorescent antibody) serology positivity 24.7%. contrasted to this, no positive slides, only 3 palpable spleens and a 3.4% serology positivity rate were found for the low incidence area. twent ... | 1975 | 1091165 |
| malaria--the mime revisited: fifteen more years of experience at a new york city teaching hospital. | purpose and patients: a previous review of the new york hospital experience with malaria during 1968 to 1975 summarized clinical and parasitologic features in 24 travelers and highlighted deficiencies in both chemoprophylaxis and diagnosis. to extend this original study, we describe 86 patients with malaria seen at the same hospital during the subsequent 15 years. results: eighty patients were infected with a single plasmodium species, and 60% had plasmodium falciparum infection primarily acquir ... | 1992 | 1524074 |
| new serological test for malaria antibodies. | in an enzyme-linked immunosorbent assay test for malaria antibodies, antibodies to plasmodium vivax and p. falciparum in man are detected using a crude antigen prepared from the simian malaria parasite p. knowlesi. the test may be suitable for epidemiological studies. | 1975 | 1092412 |
| serological relationship of tumor necrosis factor-inducing exoantigens of plasmodium falciparum and plasmodium vivax. | exoantigens of plasmodium vivax-parasitized erythrocytes stimulated macrophages to secrete tumor necrosis factor, and antisera raised against the exoantigens inhibited this secretion. the antisera also inhibited the activity of plasmodium falciparum and plasmodium yoelii exoantigens, and conversely, antisera against the latter cross-reacted with the exoantigens of p. vivax. | 1992 | 1541540 |
| the susceptibility of the indonesian i/cdc strain of plasmodium vivax to chloroquine. | a strain of plasmodium vivax from indonesia was adapted to splenectomized aotus and saimiri monkeys and tested for its susceptibility to chloroquine. animals were infected by intravenous inoculation of heparinized parasitized blood and subsequently treated with 8 or 15 mg (base) of chloroquine by oral intubation. recrudescence of infection occurred in 4 of 4 aotus and 5 of 6 saimiri monkeys treated with 15 mg base of chloroquine, indicating a level of resistance between that of the standard ches ... | 1992 | 1556649 |
| antibody response to the circumsporozoite protein of plasmodium vivax in naturally infected humans. | the circumsporozoite (cs) protein of plasmodium vivax consists of a central repeat region flanked by highly conserved non-repeat regions. serum samples from 33 individuals with naturally acquired infections of p. vivax were tested for antibodies to four antigens representing the vivax cs protein. three recombinant proteins containing different overlapping sequences in the non-repeat regions and either the entire central repeat region (vivax-1 and vivax-2) or two of the repeat sequences (vivax-3) ... | 1992 | 1373042 |
| localization of circumsporozoite protein in the sporogonic stages of plasmodium vivax. | | 1992 | 1557329 |
| the first field trials of the chemically synthesized malaria vaccine spf66: safety, immunogenicity and protectivity. | this paper reports the results of the first field study performed to assess the safety, immunogenicity and protectivity of the synthetic malaria vaccine spf66 directed against the asexual blood stages of plasmodium falciparum. clinical and laboratory tests were performed on all volunteers prior to and after each immunization, demonstrating that no detectable alteration was induced by the immunization process. the vaccines were grouped as high, intermediate or low responders according to their an ... | 1992 | 1557934 |
| immunoenzymatic labeling of multiple plasmodial salivary gland sporozoites in a single test. | a direct, double- and triple-staining immunoenzymatic method detected and differentiated sporozoites by color in anopheles stephensi salivary glands and in mixed sporozoite slide preparations. a double-staining method used beta-galactosidase- and alkaline phosphatase-labeled monoclonal antibodies to the circumsporozoite (cs) proteins of plasmodium berghei and p. falciparum in mosquito salivary glands. the cs proteins were distinguished clearly by the blue-green and red substrate products of beta ... | 1992 | 1558271 |
| reinforcement of immunity in saimiri monkeys following immunization with irradiated sporozoites of plasmodium vivax. | to determine the duration of immunity to plasmodium vivax following immunization, six saimiri sciureus boliviensis monkeys were vaccinated with irradiated sporozoites of p. vivax and challenged multiple times with sporozoites. over a period of almost four years, complete protection from repeated challenge with infective sporozoites was demonstrated in one monkey; protection in two monkeys was obtained on eight of nine occasions, in one monkey on seven of nine occasions, in one monkey on six or n ... | 1992 | 1558272 |
| [the preparation and identification of anti-idiotypic antibody against plasmodium vivax at erythrocytic stages]. | through hypotonic dialyzing and gel filtration on sephadex g200, 6h7g11 mcab-igm (mouse igm) was successfully purified. anti-6h7g11id (ab2) was induced in rabbit. this ab2 was identified by agar diffusion, elisa and competitive assays. the results showed that the ab2 was able to combine respective ab1 (6h7g11mcab), and the binding between ab2 and ab1 could be inhibited by plasmodium vivax (p.v) antigen. meantime, by using ab2 thus prepared to immunize balb/c mice, the anti-6h7g11id (ab3 or ab1') ... | 1992 | 1383120 |
| dynamics of fever and serum levels of tumor necrosis factor are closely associated during clinical paroxysms in plasmodium vivax malaria. | paroxysms are sharp episodes of high fever accompanied by chills and rigors that occur periodically, once in every 48 hr in plasmodium vivax infections. we have measured the changing levels of serum tumor necrosis factor (tnf) during paroxysms in non-immune patients infected with p. vivax malaria. the changes in tnf levels closely paralleled the rise and fall in temperature during the paroxysms but tended to precede them by 30-60 min. these observations suggest that the rise and fall in temperat ... | 1992 | 1565611 |
| presence of antibody to a heterologous circumsporozoite protein of plasmodium vivax (vk247) in southeastern bangladesh. | | 1992 | 1566294 |
| [the phenomenon of the delayed initial attack of tertian malaria]. | from 1986 to 1990 we have treated 215 patients with falciparum malaria. in 8 patients (4%) who had not returned to any malarial area, malaria attacks recurred after 6-20 weeks. curiously these were now caused by different species: plasmodium vivax (4 patients) and p. ovale (4 patients). after proper management of malignant tertian malaria caused by p. falciparum, patients are considered cured, provided the treatment has been in accordance with the resistance pattern of the parasite in the countr ... | 1992 | 1407184 |
| molecular cloning and serological characterization of a new plasmodium vivax recombinant antigen which contains apolipoprotein b-100 like sequences. | we have isolated a new recombinant antigen 'pv12' of plasmodium vivax by immunological screening of the genomic library. the antigen shows a sequence homology with human apolipoprotein b-100. a large number of p. vivax infected individuals (79%) were seropositive against this antigen. the probable function of this antigen could be to evade the host defence system (i) by inactivating the perforin of natural killer cells and (ii) by engaging the host immune system to produce antibodies against thi ... | 1992 | 1575740 |
| congenital malaria in infants of asymptomatic women. | | 1992 | 1596812 |
| [autochthonous malaria in brittany]. | | 1992 | 1596964 |
| development of a polymorphic strain of plasmodium vivax in monkeys. | a strain of plasmodium vivax from thailand with a polymorphic repeat unit of the circumsporozoite protein was established in saimiri sciureus boliviensis and 3 species of aotus monkeys. all 11 attempts to transmit infection via sporozoite inoculation, 4 times to splenectomized s. sciureus boliviensis, 2 times to splenectomized aotus nancymai, and 5 times to intact saimiri monkeys, were successful. anopheles freeborni, anopheles stephensi, anopheles dirus, and anopheles gambiae mosquitoes were in ... | 1992 | 1597793 |
| mefloquine resistant p. vivax malaria in png. | | 1992 | 1603018 |
| malaria in aberdeen: an audit of 110 patients admitted between 1980-1991. | all 110 patients seen in north east scotland after contracting malaria from foreign travel were treated in the regional infection unit in aberdeen. those patients managed there from january 1980 to march 1991 are described. there were 54 episodes of plasmodium falciparum malaria (49%) and 26 episodes (23%) of plasmodium vivax malaria. the remainder had either mixed infection or were diagnosed as malaria on high clinical probability. the majority of the patients were male (80%) and under 40 years ... | 1992 | 1411477 |
| a polytene chromosome study of four populations of anopheles aquasalis from venezuela. | polytene chromosome studies were undertaken to elucidate taxonomic relationships among populations of anopheles aquasalis and a. emilianus in venezuela. four collection sites were chosen: two in sucre state (santa fe and guayana) where a. aquasalis (considered to be a. emilianus by gabaldón and escalante) is presumed to be the major regional vector of plasmodium vivax; and two in areas where no malaria transmission occurs (caño rico, aragua state, and puerto cabello, carabobo state). the chromos ... | 1992 | 1618392 |
| a monoclonal antibody directed against the sporozoite stage of plasmodium vivax binds to liver parenchymal cells. | the circumsporozoite (cs) protein of malaria parasites is a major surface protein of the sporozoite stage. in the process of investigating the immunogenicity of this protein in the plasmodium vivax complex, we found that a monoclonal antibody (mab) directed against the cs protein of isolates of p. vivax recognizes new world monkey hepatocytes and human hepatoma cells hepg2a16 in western blot and by immunoelectron microscopy. the mab nvs3 binds to the amino acid sequence agdr, which is also share ... | 1992 | 1428005 |
| circumsporozoite genotyping of global isolates of plasmodium vivax from dried blood specimens. | the prevalence and global distribution of two circumsporozoite (cs) genotypes of plasmodium vivax (vk210 and vk247) were determined by genetic analysis of isolates from 234 malaria-infected patients. whole blood specimens were collected on filter paper from patients infected with malaria in thailand, mexico, papua new guinea, peru, afghanistan (pakistan), india, and western africa and from 50 asymptomatic smear-negative controls. following extraction of dna from the filter paper samples, the cs ... | 1992 | 1629344 |
| transmission blocking immunity to human plasmodium vivax malaria in an endemic population in kataragama, sri lanka. | serum effects on gametocyte infectivity, that is, transmission blocking/enhancing immunity, were measured in the sera of 196 acute plasmodium vivax patients who were residents of a malaria region in kataragama, southern sri lanka. direct mosquito feedings were also performed on 170 of these patients. sera of about 48% of patients suppressed gametocyte infectivity significantly (by more than 75%) and of a smaller proportion (12%) had pronounced infectivity enhancing effects. transmission immunity ... | 1992 | 1437231 |
| malaria and widal reaction. | widal reaction was studied in 52 patients having malaria parasites in the peripheral blood smear. twenty had plasmodium vivax, 26 had plasmodium falciparum and the rest had mixed (both vivax and falciparum) infections. widal test for both o and h antigens of salmonella typhi was positive in high titres in 3 falciparum, 3 vivax and 2 cases of mixed infection. of these 8 cases, one had been treated for typhoid fever 3 months back and again one month back for relapse. blood culture for salmonella t ... | 1991 | 1669964 |
| rapid diagnosis of malaria by fluorescence microscopy with light microscope and interference filter. | fluorochrome staining to detect malaria parasites in bloodfilms is more sensitive, is easier to do, and is less time-consuming than giemsa staining. however, standard epi-illuminated, mercury vapour, fluorescence microscopes are expensive, especially for tropical countries where malaria is endemic. fluorescence microscopy with a standard light microscope and a new interference filter specially designed for the fluorochrome stain, acridine orange, was used to detect malaria parasites in thick and ... | 1991 | 1670842 |
| an immunocytochemical test for the diagnosis of antibodies to plasmodium vivax. | an immunocytochemical peroxidase test (icpt) has been developed to allow serological measurement of the antibody response to plasmodium vivax by light microscopy. acetone fixed p. vivax erythrocyte stages were used as source of antigen. the immunofluorescent antibody test (ifat) was used as reference test. in testing sera from individuals infected with p. vivax in southeastern venezuela a high correlation (100%) was obtained between the icpt and the ifat. there were cross reactions with sera fro ... | 1992 | 1437238 |
| chloroquine-resistant plasmodium vivax in papua new guinea. | an australian expatriate on regular weekly antimalarial prophylaxis with chloroquine base and maloprim developed symptomatic plasmodium vivax infection which failed to respond adequately to 600 mg of chloroquine base. more ominously, a resident of the highlands region of papua new guinea contracted vivax malaria which failed to be cleared by 2400 mg chloroquine base administered over 4 d. both patients had achieved appropriate blood and plasma concentrations of chloroquine after treatment. chlor ... | 1992 | 1440763 |
| immune responses against sexual stages of plasmodium vivax during human malarial infections in sri lanka. | during natural infections of p. vivax malaria a variety of immune responses to the infection affect infectivity of the parasites to mosquitoes. sexual stage antigens present in the blood stage parasites induce antibodies which may either enhance or suppress the infectivity of the sexual parasites to mosquitoes. subsequent infections of p. vivax do not, unless occurring within less than 4 months, boost this response indicating a very short immune memory for the relevant antigens. blood infection ... | 1991 | 1688139 |
| identification of a t-cell epitope on the circumsporozoite protein of plasmodium vivax. | a series of overlapping peptides, representing sequences in the vicinity of region ii on the plasmodium vivax circumsporozoite protein, was synthesized. one of the peptides (pv-23), a 20-mer containing the 6 c-terminal amino acids of region ii, was found to evoke an in vitro t-cell proliferative response in spleen cells from c3hf (h-2km2) mice immunized with the peptide. these results demonstrate that pv-23 contains a t-cell epitope. to our knowledge, this is the first report of a t-cell epitope ... | 1990 | 1688828 |
| chloroquine resistance in plasmodium vivax: the first case in brazil. | | 1992 | 1440766 |
| genetic complexity of plasmodium vivax parasites in individual human infections analyzed with monoclonal antibodies against variant epitopes on a single parasite protein. | monoclonal antibodies against variant epitopes of a highly polymorphic protein (pv200) in schizonts of plasmodium vivax have been used to analyze the variety of genetically distinct populations of parasites present in the peripheral blood of individual p. vivax infections in sri lanka. in 9 out of 10 isolates of freshly drawn p. vivax infected blood from different individuals, parasites of only 1 pv200 serotype was found within each individual infection, even though parasites were serotypically ... | 1990 | 1690521 |
| human immune response directed against plasmodium falciparum heat shock-related proteins. | heat shock-related stress proteins present in all eucaryotes and procaryotes have been shown to be immune targets in a broad range of infections. we have analyzed sera from people exposed primarily to plasmodium falciparum for specific antibodies against two heat shock-related proteins (proteins similar to the heat shock protein with a molecular weight of 75,000 [pfhsp] and a glucose-regulated protein with a molecular weight of 72,000 [pfgrp]). in an immunoprecipitation analysis with metabolical ... | 1990 | 1691147 |
| [malaria in the dunkerque hospital center from december 1979 to december 1990]. | seventy-one cases of malaria were diagnosed in the hospital of dunkerque from 1979 to 1990. forty-five patients have been infected in the comores islands. among the 24 other imported cases, 17 (71%) have been contaminated in western or central africa. one case of congenital malaria and one of malaria acquired by blood transfusion are also reported. plasmodium falciparum was detected in 84.5% of the patients. the four human species were found among the comorians. two cases with abnormal forms of ... | 1992 | 1443798 |
| high frequency of antibody response to plasmodium falciparum gametocyte antigens during acute malaria infections in papua new guinea highlanders. | sera from 62 adult papua new guinea highlanders with suspected acute malaria were tested by competitive elisa for the presence of antibodies capable of inhibiting binding of 8 monoclonal antibodies (mabs) directed against epitopes on gametocytes of plasmodium falciparum. between 33% and 72% of the malaria cases were inhibitory, depending on the mab. there was no difference between the proportion of persons with p. falciparum (asexuals or gametocytes) and p. vivax whose sera inhibited mab binding ... | 1990 | 1695490 |
| safety and immunogenicity of a plasmodium vivax sporozoite vaccine. | a recombinant dna plasmodium vivax sporozoite vaccine containing the repeating region of the salvador i strain circumsporozoite (cs) protein was produced in escherichia coli. this vaccine was tested in 13 naive volunteers at doses of 10-1,000 micrograms. no serious adverse reactions were noted. none of 4 volunteers receiving the 10 micrograms dose developed antibodies measurable by elisa. six of 9 volunteers in the other dose groups developed measurable antibodies: 5 of 5 volunteers receiving 10 ... | 1990 | 1695491 |
| malaria parasitological indices in the cordillera province (santa cruz department, bolivia). | in 1988-1989, as part of a co-operative programme with the local unidad sanitaria, two cross-sectional surveys were carried out to study the prevalence of malaria in eight villages in the rural areas near camiri, boyuibe and gutierrez (cordillera province, santa cruz department, bolivia). thick and thin blood films were collected from all available two- to nine-year-old children at the end of the dry season, in the first survey (252 samples), and after the rainy season, in the second survey (346 ... | 1992 | 1449271 |
| inability of malaria vaccine to induce antibodies to a protective epitope within its sequence. | saimiri monkeys immunized with a recombinant protein containing 20 copies of the nine amino acid repeat of the plasmodium vivax circumsporozoite (cs) protein developed high concentrations of antibodies to the repeat sequence and to sporozoites, but were not protected against challenge. after intravenous injection of an immunoglobulin g3 monoclonal antibody (nvs3) against irradiated p. vivax sporozoites, four of six monkeys were protected against sporozoite-induced malaria, and the remaining two ... | 1991 | 1704150 |
| t cell epitopes of the circumsporozoite protein of plasmodium vivax. recognition by lymphocytes of a sporozoite-immunized chimpanzee. | the humoral and cellular antisporozoite immune responses of a laboratory-born chimpanzee were measured following multiple exposures to the bites of plasmodium vivax-infected mosquitoes. t cell lines and clones derived from the chimpanzee's pbl were used to identify t cell epitopes of the p. vivax circumsporozoite (cs) protein. two independently obtained cell lines, established by culturing the pbl with either a recombinant p. vivax circumsporozoite (rpvcs) protein or a pool of synthetic peptides ... | 1991 | 1704402 |
| biochemical alterations in plasmodium vivax-infected malarial patients before and after radical treatment. | biochemical alterations in 152 malaria patients infected with plasmodium vivax were studied and the effect of parasitaemia on these changes was assessed. the degree of parasitaemia correlated positively with plasma uric acid, total and unconjugated bilirubin. a decrease in the levels of serum total protein, albumin, serum total, free and ester cholesterol was observed in vivax malaria. a follow-up study done on a section of the above patients after administration of chloroquine and primaquine fo ... | 1992 | 1459303 |
| involvement of gastrointestinal tract in plasmodium vivax malaria. | | 1992 | 1459306 |
| plasmodium vivax and p. falciparum epidemiology in gambella, south-west ethiopia. | plasmodium vivax and p. falciparum epidemiology were studied for parasitological and entomological samples collected during the period 1989 and 1990, respectively, from gambella, south west ethiopia. of the total population examined (n = 1091), 147 (13.5%) were found to be positive for malaria parasites. prevalence rates among males and females were 13.8% and 13.1%, respectively. differences in the prevalence rates of malaria in the eleven villages were observed, the highest (33.3%) being in uku ... | 1992 | 1470839 |
| world malaria situation in 1989. part ii. | | 1991 | 1720650 |