pharmacokinetics of antimalarials and proposals for dosage regimens. | blood level data for the antimalarials amodiaquine, chloroguanide, chloroquine, pyrimethamine, quinine and sulphadoxine have been retrieved from the literature and pharmacokinetically analyzed. minimum, average and maximum blood level concentrations at steady state in suppressive treatment and peak concentrations in therapeutic treatment were predicted and blood level-time curves simulated. based on the computer-predicted data, changes in dosage regimens are proposed to reduce the fluctuations b ... | 1978 | 359493 |
[post-transfusion pernicious plasmodium falciparum attack in a patient with renal insufficiency]. | the authors report one case of transfusion induced falciparum cerebral malaria. among the parasites responsible for transfusion malaria, plasmodium falciparum is rarely implicated, but may be accompanied by serious complications. different ways of artificial transmission of the parasites are reported. clinical findings are few, so the examination of blood films is essential for diagnostic. the dangerous blood donor must be identified by immunofluorescent methods. the specific treatment is quinin ... | 1977 | 352559 |
cellular mechanism for the protective effect of haemoglobin s against p. falciparum malaria. | | 1978 | 353566 |
[epidemiology and clinical aspects of malaria in switzerland]. | plasmodium falciparum is the predominant plasmodium species in africa south of the sahara to a proportion of 80% and more. two thirds of all cases of malaria in switzerland are imported from africa. accordingly, malignant malaria is more frequently diagnosed in switzerland than tertian malaria. malignant malaria usually presents atypically, e.g. as acute gastrointestinal disease or as shock. the lethality is high. the majority of swiss travellers are not protected effectively against malaria. a ... | 1978 | 362526 |
[malaria incurred in france]. | | 1978 | 353710 |
[malaria: direct interhuman contamination]. | | 1978 | 353711 |
[errors in diagnosis of imported malaria]. | | 1978 | 354017 |
[imported malaria in the soviet and foreign citizens]. | | 1978 | 354018 |
lymphocyte mitogenic factor in sera from patients with falciparum malaria. | to test for the presence of a lymphocyte mitogenic factor in malaria, sera were obtained from 10 patients with malaria (9 with falciparum and one with vivax), and 10 noninfected controls. the sera from the malarial patients caused an increased blastogenesis in mouse splenic lymphocyte cultures and inhibited hemagglutination between lipid-a-coated erythrocytes and lipid-a antibodies. none of the sera were positive using the limulus amebocyte lysate test. these results could be interpreted to demo ... | 1978 | 354145 |
the biological suppression of malaria: an ecological and nutritional interrelationship of a host and two parasites. | the interrelationship of malaria and severe ascariasis was studied in anjouan children with a previously described syndrome of enlarged parotids, localized forehead edema, heavy infestation with ascaris lumbricoides, and unusual freedom from malaria. after treatment of 37 such children with the ascaricide piperazine, 35 had resolution of parotid enlargement and forehead edema, but 19 developed attacks of malaria. children treated with placebo had neither resolution of clinical findings nor attac ... | 1978 | 354372 |
[parasitological diagnosis of malaria by concentration of parasitized erythrocytes: technic and preliminary results]. | | 1977 | 354817 |
[acute renal insufficiency caused by plasmodium falciparum malaria in the last period of pregnancy (2 cases) (author's transl)]. | a report of 2 cases of acute renal insufficiency in african women, 8 months pregnant and suffering of malignant malaria. in both cases labor has been induced by artificial breaking of the membranes and use of oxytocin. one of the children was still-born and the other died 3 days later. delivery has been followed by a resumption of the urinary flow, facilitated by high dosages of furosemide. this diuretic drug when associated with hypoprotidic diet, hypercaloric intravenous infusions of glucose h ... | 1978 | 364241 |
[the question of endemic malaria in republic of djibouti (author's transl)]. | since 1973 autochthonous cases of malaria due to p. falciparum have been reported among local population of french afars and issas territory; 191 cases observed between 1973 and 1976 are recorded. their monthly distribution and geographical repartition are studied, jointly with the distribution of a. gambiae which has been recently collected in the territory. this study shows a significant correspondance between the presence of a. gambiae and the malaria cases observed which did not come from ne ... | 1978 | 364244 |
topical aspects of the epidemiology of malaria. | | 1978 | 355188 |
some recent advances in the cultivation of plasmodium falciparum. | | 1978 | 355191 |
human parasitoses of the malili area, south sulawesi (celebes) province, indonesia. | a biomedical survey was conducted in 9 villages in the malili area of south sulawesi, indonesia. blood specimens were examined for malaria and microfilariae; stool specimens were examined for intestinal parasites. malaria parasitemias were rare; plasmodium falciparum was detected in 10 and p. vivax in 11 of 985 blood smears. malayan filariasis was endemic to all villages surveyed. the overall prevalence of detectable microfilaremias was 15%, varying from 34% in kawata to 1% in nuha. microfilaria ... | 1978 | 364674 |
immunopathology of human malaria. | | 1978 | 355197 |
comments on seroepidemiologic studies. | if the tools for the control of transmission are not available, the application of seroepidemiologic methods, as an exercise in the tropics, just in order to assess the magnitude of the problem of malaria transmission, should be restricted. application of seroepidemiologic methods in connection with control operations seems valuable. they can provide new and basic information. it is very unlikely that in control schemes, the assessment of incidence of fresh parasitemias is better, easier, or mor ... | 1978 | 355205 |
the spread of chloroquine-resistant falciparum malaria in papua new guinea. | two cases of chloroquine-resistant plasmodium falciparum malaria have been reported from eastern papua new guinea in order to alert the medical profession about the spread of resistant strains throughout that territory. | 1978 | 355814 |
the duffy blood group and resistance to plasmodium vivax in honduras. | to test the hypothesis that the duffy blood group negative genotype is a factor in resistance to plasmodium vivax, we determined the duffy blood group, the malaria antibodies, and the slide-demonstrated infection rates with p. vivax and p. falciparum of 420 persons living in nueva armenia, honduras. in all, 247 persons were duffy negative. demonstrated infections with p. falciparum were almost equally distributed between duffy-positive (5,8%) and duffy-negative (4.9%) persons. similarly, duffy-p ... | 1978 | 356634 |
[5 cases of imported malaria]. | | 1978 | 358306 |
plasmodium falciparum in culture: establishment of additional strains. | the establishment of new strains of plasmodium falciparum in continuous culture is described. one line (fcr-2), isolated from an individual who had traveled extensively through south america, was passed initially through aotus trivirgatus monkeys and then cultured into human erythrocytes using the flow-vial technique. a strain of p. falciparum fmg), shipped by air freight on wet ice from the gambia, was cultured directly from a human infection into continuous culture using the petri dish-candle ... | 1978 | 356635 |
chemoprophylaxis of malaria. | | 1978 | 356694 |
continuous in-vitro cultivation of the human malaria parasite. | | 1978 | 356695 |
presumptive treatment of p. vivax and p. falciparum cases with 600 mg. chloroquine base in tamil nadu. | | 1978 | 365722 |
[reappearance of autochthonous malaria]. | | 1978 | 356696 |
[malaria introduced into switzerland from 1974-1976]. | in recent years there has been an increase in imported tropical diseases in switzerland. travellers to the tropics are often inadequately or not at all informed about the dangers and possible prophylaxis of infection. this is true for malaria, of which 207 cases covering the years 1974 to 1976 are studied. most involved were people between 21 and 30 years old. the main infections (71%) come from african countries. plasmodium falciparum was found somewhat more frequently than p. vivax. only a sev ... | 1978 | 360380 |
sickling rates of human as red cells infected in vitro with plasmodium falciparum malaria. | the kinetics of sickling of malaria-infected red cells from humans with sickle cell trait were studied in vitro in an attempt to obtain direct experimental evidence for a selective advantage of the hemoglobin s heterozygote in a malarious region. the sickling rates of cells infected with plasmodium falciparum and of non-infected cells were studied both in the total absence of oxygen (by dithionite addition) and at several different concentrations of oxyhemoglobin which might obtain in vivo. in a ... | 1978 | 360396 |
the treatment of malaria. | | 1978 | 366774 |
an integrated view of entomological and parasitological observations on falciparum malaria in gambela, western ethiopian lowlands. | | 1978 | 360497 |
malaria in birmingham and a london teaching hospital. | during the past five years the incidence of imported malaria increased among patients seen in east birmingham hospital and in st thomas's hospital, london. plasmodium vivax was the predominant species in birmingham, and was almost always acquired by asian immigrants visiting the indian subcontinent. in st thomas's p falciparum was most commonly imported, usually by african immigrants visiting nigeria and ghana. two patients (one irish, one japanese) died of falciparum malaria after visiting trop ... | 1979 | 367507 |
a study of the role of immunological factors in the pathogenesis of the anaemia of acute malaria. | children with acute plasmodium falciparum malaria and anemia were investigated to see if immunological factors could be implicated in the pathogenesis of their anaemia. direct coombs tests using an anti-whole immunoglobulin antiserum were negative in all 12 children tested but two had positive tests with antisera to c3b and c3d. low plasma levels of c3 and c4 were found but these were not significantly different from values found in a group of children with acute malaria who were not anaemic. se ... | 1978 | 360499 |
chloroquine-resistant falciparum malaria. | | 1979 | 368534 |
preventing deaths from malaria. | to reduce the number of avoidable deaths from malaria in britain the following five points are recommended. parliament should pass a malaria prevention act that compels travel agents and airlines to give written and verbal advice on prevention and diagnosis of malaria to people travelling to countries where the disease occurs. to improve diagnostic and therapeutic efficiency for all diseases the department of health and social security should prepare a procedure manual for the nhs that gives gui ... | 1978 | 361151 |
prevalence of chloroquine resistance in malaria. | | 1978 | 361680 |
[malaria caused by accidental inoculation. 1 case]. | the authors report a case of direct infection of a nurse who had taken blood sample from a young patient suffering from malaria due to plasmodium falciparum. six similar observations have been reported in the literature. in addition, accidental infection has been observed following the use of non sterile syringes. as a result, malaria could be an unexpected consequence of the drug habit. | 1978 | 369732 |
the treatment of malaria. | | 1978 | 362573 |
response of plasmodium falciparum in sudan to oral chloroquine. | the chloroquine sensitivity of plasmodium falciparum was studied in two areas of sudan. in the gezira, 99.2% of the patients tested responded completely to the drug. two patients (0.4%) and one patient (0.2%) showed, respectively, ri and rii responses. however, in those showing ri response reinfection could not be excluded. in an area of southern sudan patients could only be followed-up for 7 days; nevertheless, this was sufficient to exclude the presence of rii and riii responses there. this st ... | 1978 | 362953 |
species prevalence of malaria in northern and southern sudan, and control by mass chemoprophylaxis. | a survey in northern and southern sudan showed that plasmodium falciparum is the predominant species in malaria cases, occurring in 91% and 87%, respectively of the positive cases in these two regions. p. ovale was extremely rare in southern sudan and was absent in the north. the survey, which was carried out during the transmission season in northern sudan, showed that malaria is common, occurring in 62% of those tested in some villages. a trial of mass chemoprophylaxis resulted in a marked de ... | 1978 | 362954 |
distribution of human plasmodia in karnataka and tamil nadu states in the reappearing phase of malaria in 1970 and 1975. | | 1979 | 372102 |
[autopsy case of plasmodium falciparum malaria]. | | 1978 | 372631 |
results of treatment of plasmodium falciparum infection with chloroquine in some parts of tamil nadu. | | 1978 | 363614 |
falciparum malaria with acute pulmonary insufficiency. report of a survived case. | | 1978 | 363959 |
differentiation of gametocytes in microcultures of human blood infected with plasmodium falciparum. | gametocytes differentiated from ring-stage parasites in microcultures of human blood infected with plasmodium falciparum. immature gametocytes could be distinguished morphologically from late asexual trophozoites after approximately 40 h of culture. differentiation into crescentic forms took several days and the incorporation of [3h]-isoleucine by developing gametocytes was demonstrated. about 1% of red cells contained gametocytes at the maxiumum densities attained. differentiation of gametocyte ... | 1978 | 364046 |
chloroquine-resistant falciparum malaria from africa. | | 1979 | 364085 |
[control of malaria and its eradication in the socialist republic of vietnam]. | | 1978 | 364292 |
trends in the development of chemotherapy for parasitic diseases. | | 1978 | 364672 |
standardization of the indirect fluorescent antibody test for malaria. | methods are described whereby results of malarial immunofluorescence tests can be evaluated objectively. the ifa test was quantitated by standardizing the physical system against a fluorescent standard and preparation of biological standards of malarial antisera and fluorescein labelled conjugates. using these known standards the reactivity of antigens was characterized. it was found that antigen preparations are best when they include mature schizonts, and keep best when they are stored in a dr ... | 1978 | 364783 |
detection and measurement of species-specific malarial antibodies by immunofluorescence tests. | species-specific serodiagnosis of malaria could be made by means of the standardized indirect fluorescent antibody test, either by determination of the usual end-point titres or by fluorescent intensity measurements on antigens. the malarial antibody levels could also be measured by the fluorescent intensity measurements at a single serum dilution. thus the fluorescent intensity measurements could effectively replace the end point titre determination, with the advantages of standardization and s ... | 1978 | 364784 |
an ultrastructural study of the sporogonic development of plasmodium falciparum in anopheles gambiae. | this paper describes the fine structure of the sporogonic development of plasmodium falciparum in its natural vector anopheles gambiae (species a) as seen by scanning and transmission electron microscopy. the parasite was derived from naturally infected volunteers and the vector maintained under natural conditions at the mrc laboratories, fajara, the gambia. sporogonic development of p. falciparum is similar to that described for other plasmodium spp. there are however greater similarities betwe ... | 1978 | 364785 |
urban malaria and its vectors in salem (tamil nadu): natural and induced infection with human plasmodia in mosquitoes. | | 1979 | 376440 |
concentration from continuous culture of erythrocytes infected with trophozoites and schizonts of plasmodium falciparum. | gelatin, from readily available sources, at specified concentrations in rpmi 1640 medium enhances sedimentation rates of suspensions of plasmodium falciparum-infected erythrocytes from continuous cultures, resulting in an enrichment of the trophozoite- and schizont-infected cells to parasitemias of 75% or more with no deleterious effects to the parasites. | 1978 | 365006 |
further epidemiological evaluation of a malaria model. | the malaria model previously fitted to 1 year of baseline data from the garki district in the sudan savanna of northern nigeria was tested against data collected in the same area over a period of 3 years, including 1(1/2) years during which the insides of houses in certain villages were sprayed with propoxur. it was also tested against data collected in kisumu, kenya, also over a period of 3 years, including 20 months during which the insides of houses in part of the area were sprayed with fenit ... | 1978 | 365384 |
longitudinal serological study of malaria in infants in the west african savanna. comparisons in infants exposed to, or protected from, transmission from birth. | two infant populations, the one exposed to intense malaria transmission and the other protected, were followed and compared by six serological tests. the igg and igm levels increased with age and were systematically, though only slightly, lower in the protected children. the results of three plasmodium falciparum tests (precipitin, indirect fluorescent antibody (ifa) and indirect haemagglutination and one p. malariae test (ifa) were high at birth and decreased rapidly afterwards in both populati ... | 1978 | 365385 |
[imported tropical malaria in pregnant women]. | | 1979 | 377517 |
changing patterns in the humoral immune response to malaria before, during, and after the application of control measures: a longitudinal study in the west african savanna. | a longitudinal seroimmunological investigation of malaria was performed as part of the who research project conducted in the northern part of nigeria from 1970 to 1975. the project included a preintervention phase, an intervention phase with application of malaria control measures (spraying of residual insecticide and mass drug administration), and a postintervention phase. serological observations were made on the total population of eight villages consisting of approximately 3000 persons. six ... | 1978 | 365386 |
the use of exchange transfusions: a potentially useful adjunct in the treatment of fulminant falciparum malaria. | fulminant falciparum malaria with greater than 500,000/mm3 parasites in the peripheral blood portends a poor prognosis. we recently managed a patient who had greater than 1.2 million/mm3 parasitized erythrocytes in her peripheral blood, following initially inadequate antimalarial therapy, with exchange transfusion in addition to conventional chemotherapy. this patient recovered from her disease despite severe cerebral involvement and acute failure. we feel that exchange transfusion was a useful ... | 1979 | 377965 |
therapeutic use of exchange transfusion in malaria. | in the case reported here, a patient with severe plasmodium falciparum infection with 20% of erythrocytes parasitized was cured by exchange transfusion in conjunction with classical drug therapy. | 1979 | 378004 |
plasmodium falciparum: merozoite invasion in vitro in the presence of chloroquine. | | 1978 | 365561 |
chloroquine-resistant falciparum malaria. | | 1978 | 366363 |
hypocomplementaemia in children with plasmodium falciparum malaria. | | 1978 | 366818 |
haemoglobin s and p. falciparum malaria. | | 1979 | 379655 |
severe falciparum malaria during a blizzard. | | 1979 | 367562 |
venezuelan strains of plasmodium falciparum resistant to sulfa and pyrimethamine as demonstrated by in vitro test. | | 1977 | 368932 |
fansidar for falciparum malaria. | | 1979 | 380540 |
the activity of chloroquine against plasmodium falciparum in bandar abbas, southern iran, 1976. | study to monitor the susceptibility of p. falciparum to chloroquine in south iran was conducted in bandar abbas. forty-five falciparum malaria subjects who had received 25mg. chloroquine base per kg. body weight over 3 days were followed up for 4 weeks, while three other patients for a period of 1-3 weeks. no recrudescence could be confirmed among the subjects during the follow up of the study. the mean time of asexual parasites clearance was 2.15 days. the action of chloroquine against the asex ... | 1978 | 369728 |
the role of platelets in infections. i. observations in human and murine malaria. | the interaction between platelets and microorganisms may be underestimated. our in vivo studies support a direct role of thrombocytes in malarial infections. we have found intrathrombocytic parasites of plasmodium vivax (in 10% of men naturally infected) and p berghei (in 53% of mice experimentally infected); these were both merozoites and trophozoites. neither the mechanism of parasitization (whether by active penetration or by phagocytosis) nor the outcome of this phenomenon is known. however, ... | 1979 | 371580 |
concentration and separation of erythrocytes infected with plasmodium falciparum by gradient centrifugation. | concentration of infected erythrocytes was achieved in cell suspensions derived from long-term culture of plasmodium falciparum growing asynchronously in human erythrocytes. this new procedure involves the slow centrifugation (at 33 g) of erythrocyte suspensions through 5% ficoll solutions. mature asexual erythrocytic forms are preferentially retained in the gradient solution (top fraction). after further gradient centrifugation of these parasitized cells, the concentration of mature forms is in ... | 1979 | 371850 |
direct coombs antiglobulin reactions in gambian children with plasmodium falciparum malaria. i. incidence and class specificity. | gambian children with past or present plasmodium falciparum malaria were investigated for the incidence of coombs positivity using monospecific antisera. approximately 50% were positive and the most frequent form of erythrocyte sensitization was with c3d. other specificities, eigg, eiggc3d and eiggc4bc3d were less common. erthyrocytes were never found sensitized with iga or igm. there was no correlation between a positive test and age, tribal status or level of parasitaemia at presentation, alth ... | 1979 | 371880 |
clearance of falciparum parasitaemia with a single dose sulfadoxine-pyrimethamine in vientiane, laos. | a total of 49 semi-immune laotians aged 3 to 49 years, with falciparum malaria were treated with a single dose of sulfadoxine pyrimethamine (1500 mg, 75 mg, adult dose), in vientiane, laos. on day 7 after treatment the 49 cases were asymptomatic with complete disappearance of patent asexual parasitaemia. the result is compared with that obtained from treating 48 similar cases with a standard dose of chloroquine over 3 days. | 1978 | 373131 |
[course and intensive treatment of acute falciparum malaria (author's transl)]. | the case of a nineteen-year-old women with the cerebral form of malaria tropica is reported. she showed hyperpyrexia, abdominal manifestations, haemolysis and disseminated intravascular coagulation. cerebral symptoms amounting to grade iv encephalopathy occurred. the patient responded rapidly to the administration of chloroquine, anticonvulsants, dextran, corticosteroids, antipyretics, blood and antithrombin iii and her symptoms had almost completely vanished one week after the onset of therapy. | 1979 | 373259 |
single-dose therapy of falciparum malaria with mefloquine or pyrimethamine-sulfadoxine. | a single oral dose (1.5 g) of mefloquine hydrochloride cured all of 37 patients with falciparum malaria, and a single dose of pyrimethamine (75 mg) plus sulfadoxine (1.5 g) cured 34 of 38 patients. the rates at which parasitaemia and fever abated were similar for the two regimens but mefloquine was associated with a higher incidence of gastrointestinal side effects. | 1979 | 373903 |
loss of circulating t lymphocytes with normal levels of b and 'null' lymphocytes in thai adults with malaria. | peripheral blood mononuclear cells from forty-nine thai adults infected with either plasmodium falciparum or plasmodium vivax were examined in order to determine the percentage of t, b, and fc-receptor-bearing cells present. in comparison to healthy controls, both the percentage and concentration of peripheral t cells were decreased in the malaria-infected individuals as assessed by formation of rosettes with sheep red blood cells. the percentage of peripheral b cells was increased but their co ... | 1979 | 373935 |
occurrence of malaria acquired during travel abroad among american civilians, 1970-1976. | | 1979 | 374645 |
[malaria in switzerland. clinical diagnosis and management schedule for the practitioner (author's transl)]. | | 1979 | 375456 |
serum immunoglobulin levels and malaria antibodies in burkitt's lymphoma. | data are presented to support a relationship between malaria infection and burkitt's lymphoma in african children. igg, igm and iga levels were measured in sera from burkitt's lymphoma patients and from sex- and age-matched, nearest-neighbour controls. all three classes of immunoglobulins were present in significantly lower amounts in the sera from burkitt's lymphoma patients than in the sera from controls. the mechanism of this apparent b-cell suppression is not yet clear. malaria-specific igg ... | 1979 | 375487 |
lymphocyte changes in murine and human malaria. | | 1979 | 375510 |
falciparum malaria despite chemoprophylaxis. | | 1979 | 376057 |
immunizations for travelers. | | 1979 | 377044 |
oxidant damage mediates variant red cell resistance to malaria. | | 1979 | 377105 |
[transmission of plasmodium falciparum malaria by syringe in a patient with heroinism]. | | 1979 | 377220 |
[errors in the diagnosis of malaria]. | | 1979 | 377805 |
[autochtone malaria]. | | 1979 | 384362 |
a comparative study of malaria prophylaxis in peninsular malaysia using chloroquine and a combination of sulphadoxine and pyrimethamine. | | 1978 | 366165 |
malaria prophylaxis for visitors to papua new guinea. | | 1978 | 366358 |
in vivo and in vitro studies of quinine sensitivity of plasmodium falciparum in thailand. | forty-four patients with falciparum malaria were studied. nine patients were given quinine orally at a daily dose of 1.5 gm base for a period of 14 days. the mean parasite clearance in all 9 patients was 3.3 days, and none had recrudescence in follow-up examinations for 31 days. the in vivo study of these 9 patients showed sensitivity to quinine which correlated with the in vitro test, with concentration of quinine base 2.5-5.8 microgram/ml of blood that inhibited the maturation of plasmodium fa ... | 1979 | 384545 |
response of sensitized and unsensitized human lymphocyte subpopulations to plasmodium falciparum antigens. | antigen preparations derived from plasmodium falciparum-infected erythrocytes (but not from uninfected erythrocytes) can stimulate the in vitro proliferation of peripheral blood lymphocytes from malaria-sensitized as well as nonsensitized donors. the possibility that the nonspecific responses might be due to a parasite-derived b-cell mitogen has been previously suggested since polyclonal hypergammaglobulinemia is a frequent accompaniment of malaria infection. to test this hypothesis, we investig ... | 1979 | 378840 |
[malaria tropica with coma in early infancy (author's transl)]. | after arriving in austria a 10 month old nigerian infant fell sick with malaria tropica and survived after specific antiparasitic therapy. early diagnosis and immediate begin of treatment are stressed. | 1979 | 380183 |
plasmodium gallinaceum-parasitized chicken erythrocytes in a practical hemagglutination test for igm antibodies in human malaria. | a new hemagglutination test for human malaria, done with plasmodium gallinaceum-parasitized, aldehyde-fixed, chicken erythrocytes as a stable lyophilized reagent, is described. the test was positive in every human case of falciparum or vivax malaria in which there was parasitemia. it detected only igm anti-plasmodial antibodies and usually became negative within a few weeks after treatment. as a practical and sensitive test for active malaria, the p. gallinaceum hemagglutination test should be c ... | 1979 | 380370 |
[autochthonous malaria and malarian liver. apropos of 1 case]. | report of the case of a patient, store-keeper at the roissy airport, suffering from an autochtonous primo-invasion falciparum malaria. the clinical symptoms were hectic fever and painful hepatomegalia, followed 14 days after by a typical tertian fever. all investigations being negative, a laparoscopy was carried out, which showed a black liver, and a biopsy demonstrated the malaria pigment in küpffer cells. malaria was confirmed by the study of a blood smear. this diagnostic hypothesis had not ... | 1978 | 385159 |
falciparum malaria despite chemoprophylaxis. | | 1979 | 380749 |
malaria in australia. | | 1979 | 386057 |
chloroquine-resistant falciparum malaria. | | 1979 | 386060 |
[a patient with tropical malaria acquired in a south african safari park]. | | 1979 | 386142 |
pulmonary oedema in the falciparum malaria. | | 1979 | 380762 |
acute urticaria due to plasmodium falciparum infection. a report of two cases with a review of the english literature. | | 1979 | 380958 |
a note on in vivo chloroquine sensitivity tests in p. falciparum in some parts of karnataka state. | | 1979 | 381190 |
studies on plasmodium falciparum in continuous cultivation. i. the effect of chloroquine and pyrimethamine on parasite growth and viability. | recent advances in the in vitro study of human malaria have provided the knowledge to maintain plasmodium falciparum in continuous culture. using relatively cheap and easily obtainable materials it is now possible to study many parameters including parasite chemotherapy. the activity of two standard antimalarials, chloroquine and pyrimethamine, has been examined in vitro. the effect on the parasite is easily observed and can be measured not only as a decrease in parasite density, but also as the ... | 1979 | 386970 |
genetics of red cells and susceptibility to malaria. | | 1979 | 387115 |
partial characterization of a malaria mitogen. | supernatants from 24-hour cultures of plasmodium falciparum-infected human red blood cells stimulated lymphocytes from both malaria immune and malaria non-immune donors. both t and b lymphocytes responded. amalaria parasite-derived mitogen may play some part in the pathogenesis of the hypergammaglobulinaemia characteristic of malaria. | 1979 | 382464 |