| colony stimulating and inhibiting activities in mouse serum after corynebacterium parvum-endotoxin treatment. | | 1978 | 304892 |
| suppression of rat t cell proliferation by corynebacterium parvum: t cell requirement for induction. | | 1978 | 304893 |
| effects of corynebacterium parvum on granulocyte/macrophage production and toxicity of chemotherapy. | | 1977 | 305373 |
| a role for t lymphocytes in the antitumour action of systemic c. parvum. | the frequency of tumours arising from s.c. injection of a syngeneic chemically-induced fibrosarcoma (fsa) was not influenced by systemic administration of c. parvum (day + 3) except when doses less than the td50 were injected. then the number of takes was increased. the tumour normally grows progressively however regression was frequent in intact mice treated with c. parvum. tumour regression did not occur in t cell-depleted mice treated in the same way. splenic t cell-enriched populations of ce ... | 1977 | 305374 |
| possible mechanisms in the anti-tumour activity of c. parvum. | normal murine peritoneal macrophages exhibited anti-tumour cytotoxicity following simultaneous incubation with c. parvum and lymphoid cells from c. parvum-treated mice. both t- and b-lymphocytes appear to be involved in this macrophage activation which is mediated by a soluble factor(s) released by immune lymphoid cells in response to the specific immunising strain of c. parvum. cells capable of macrophage activation do not appear until 6 days following systemic c. parvum administration despite ... | 1977 | 305375 |
| [immunotherapy of malignant diseases. a way towards the goal?]. | | 1978 | 305530 |
| induction of interferon production in mouse spleen cell cultures by corynebacterium parvum. | | 1978 | 307432 |
| a role for t lymphocytes in tumour inhibition and enhancement caused by systemic administration of corynebacterium parvum. | | 1978 | 308542 |
| effect of corynebacterium parvum on human t-lymphocyte interferon production and t-lymphocyte proliferation in vitro. | | 1978 | 309789 |
| inhibition of memory cell-mediated cytotoxic response by systemic administration of corynebacterium parvum. | | 1979 | 311692 |
| immune function determination in patients with bladder cancer. | patients with bladder cancer were evaluated clinically for immune responsiveness and stage of disease. a battery of tests is described that attempts to correlate stage of disease with immune responsiveness. | 1978 | 311893 |
| separation of functionally distinct subpopulations of corynebacterium parvum-activated macrophages with predominantly stimulatory or suppressive effect on the cell-mediated cytotoxic t cell response. | | 1979 | 312146 |
| effects of corynebacterium parvum and bcg therapy on immune parameters in patients with disseminated melanoma. a sequential study over 28 days. ii. changes in non-specific (nk, k and t cell) lymphocytoxicity and delayed hypersensitivity skin reactions. | c. parvum and bcg produced significant changes in nk, k and t cell lymphocytotoxicity using a chang liver target cell. a consistent temporal pattern over 28 days of early depression, recovery, overshoot and then decline was described. this was particularly marked for c. parvum and 'k' cell activity. skin test reactivity to recall antigens at 28 days was not appreciably different from the pre-immunization reactivity. the importance of using lymphocyte concentration-cytotoxicity titration curves a ... | 1979 | 312169 |
| anaerobic and aerobic bacteriology of acute conjunctivitis. | aerobic and anaerobic cultures and clinical data were obtained from 131 patients presenting with acute conjunctivitis. similar cultures were obtained from 60 noninflamed individuals. anaerobes were isolated from 66 patients, 51 times in mixed culture with aerobes and 15 times (11.5%) as the only isolates. aerobes only were recovered in 54 patients. the organisms found to be statistically significantly more commonly recovered from eyes with conjunctivitis were staphylococcus aureus, hemophilus in ... | 1979 | 313179 |
| immunologic evaluation of patients with advanced head and neck cancer receiving weekly chemoimmunotherapy. | patients with advanced head and neck cancer have significant reduction in their circulating lymphocyte mass which is reflected in decreased numbers of t cells, fc receptor cells, and in derangements of t lymphocyte functions, i.e., decreased responsiveness to several dilutions of phytohemagglutinin and lack of development of delayed hypersensitivity to 2,4-dinitrochlorobenzene (70% of patients were dncb (-)). a population of phagocytic cells capable of decreasing lymphocyte responsiveness to mit ... | 1979 | 313240 |
| a trial of 5-fluorouracil and corynebacterium parvum in advanced colorectal carcinoma. | this study has confirmed that patients who have advanced colorectal carcinoma have impaired responsiveness to delayed-hypersensitivity skin testing, and also have elevated levels of serum igm. serial observations of delayed-hypersensitivity skin tests, total lymphocyte counts, t-lymphocyte counts, b-lymphocyte counts, and serum immunoglobulin levels failed to reveal any consistent pattern of responses in patients treated with either chemotherapy alone or chemoimmunotherapy. in 33 patients chosen ... | 1979 | 313873 |
| antigenic bacterial polysaccharide in rheumatoid synovial effusions. | phenol-water extracted rheumatoid synovial fluids and synovial fluid leukocytes contain an antigen immunologically identical to the proprionibacterium group bacteria. the antigen was identified by counter-immunoelectrophoresis in 70% of rheumatoid synovial fluid leukocyte pellets and in 60% of rheumatoid synovial fluids. it was also present in 6% of nonrheumatoid fluids and in 22% of nonrheumatoid inflammatory fluid leukocytes. antigen was not detectable in synovial samples before extraction. sy ... | 1979 | 314293 |
| effects of repeated corynebacterium parvum and bcg therapy on immune parameters: a weekly sequential study of melanoma patients. i. changes in non-specific (nk, k and t cell) lymphocytotoxicity, peripheral blood counts and delayed hypersensitivity reactions. | increased lymphocyte cytotoxicity, particularly of 'killer' k cell type was recorded with repeated immunizations of either c. parvum or bcg. a 3 week interval between immunizations was capable of maintaining the increase in cytotoxicity. no marked alterations of 'recall' skin hypersensitivity reactions nor of peripheral blood counts were noted. expression of cytotoxicity results as percentage 51cr release, lytic units/ml and cytotoxic capacity (after logit transformation of the cytotoxicity-lymp ... | 1979 | 314367 |
| stimulation of phosphatidylinositol turnover in the macrophage plasma membrane: a possible mechanism for signal transmission. | | 1979 | 315365 |
| [preliminary considerations on the intravenous use of corynebacterium parvum in the treatment of solid neoplasms]. | | 1979 | 315598 |
| value of immune monitoring in gynecologic cancer patients receiving immunotherapy. | immunotherapy with nonspecific immunopotentiators such as corynebacterium parvum is under study in several areas of gynecologic oncology. the efficacy of this new modality awaits the results of carefully done clinical trials designed to measure an improved effect on survival when this and similar agents are added to conventional therapy. this report deals with an attempt to demonstrate enhancement of the cell-mediated immune response in a small number of patients with advanced ovarian (18 patien ... | 1979 | 315714 |
| association of host immunoglobulins with solid tumours in vivo. | using a direct radioimmune antiglobulin technique and a competitive double-antibody radioimmune assay, we have demonstrated the presence of appreciable amounts of host immunoglobulins on the surface and in extracts of cell suspensions from freshly excised solid tumours. iga appeared to have the greatest concentrations from freshly excised solid tumours. iga appeared to have the greatest concentration, followed in turn by igm congruent to igg2a greater than igg1 congruent to igg2b greater than ig ... | 1979 | 315785 |
| [the bacteriological and biological significance of propionibacterium acnes--the indigenous bacteria of human skin. iv. age-related change in antibody to p. acnes in normal human sera (author's transl)]. | | 1979 | 316030 |
| effects of endotoxin and extracts of pregnant mouse uterus on the recovery of hemopoiesis after 5-fluorouracil. | a single injection of endotoxin, 4 hours after administration of 150 mg/kg of 5-fluorouracil (5-fu), stimulated the recovery of bone marrow hemopoietic cells that form colonies in spleen (cfu-s) or in culture (gm-cfc), of erythropoiesis, and of platelet production. corynebacterium parvum injections had similar effects. endotoxin-free extracts of tissues (from pregnant mouse uterus, placenta, and embryo) which have a high content of the factor(s) capable of stimulating growth of gm-cfc in vitro a ... | 1979 | 316724 |
| inhibition of host resistance by nutritional hypercholesteremia. | previous experiments showed that nutritionally induced hypercholesteremia in mice caused an increase in susceptibility to coxsackievirus b, with a marked suppression of cellular infiltrates in infected tissues and an increased mortality. the present studies demonstrated that a hypercholesteremic diet was associated with an inhibition in host resistance as measured by susceptibility to listeria monocytogenes infection and the growth of two transplanted syngeneic murine tumors. moreover, the abili ... | 1979 | 317596 |
| response of lympho-hemopoietic tissue to corynebacterium parvum by study of dna enzymes and h3-tdr metabolism. | the effects of corynebacterium parvum on the lymphohemopoietic tissues of mice was investigated by h3-tdr metabolism, organ weights, dna-polymerase-alpha activity and terminal deoxynucleotidyl transferase (tdt) activity. marked increase in spleen size occurred. the increase in size was accompanied by increases in dna-p-alpha activity and h3tdr uptake. this indicated that the spleen was a major site of cell proliferation and of increase in population size after c. parvum stimulation. thymus and b ... | 1979 | 317898 |
| inhibitory effect of propionibacterium acnes on the growth on syngeneic tumor transplants in nude mice. | | 1979 | 318050 |
| a comparison of pyrogenicity and related properties seen in a suspension of corynebacterium parvum and a gramnegative organism. | when the pyrogenic properties of c. parvum and a gramnegative organism, s. typhimurium, were compared it was found that the onset of the pyrogenic response to c. parvum was delayed relative to that of s. typhimurium and that secondary responses rarely occurred. in further experiments the interaction of c. parvum and s. typhimurium was studied. although synergism was not demonstrated, the kinetics of the response to mixtures of the two vaccines was anomalous while pre-treatment of rabbits with c. ... | 1977 | 320069 |
| tumor immunology and immunotherapy. | tumor cells contain a variety of antigens, including tumor associated antigens. the tumor associated antigens can be clinically useful as markers for detection of cancer and some may also mediate host resistance against tumor growth. much emphasis has been placed on the detection of circulating tumor associated markers, with radioimmunoassays for carcinoembryonic antigen (cea) being extensively utilized. at present, cea does not appear to be promising for initial detection of cancer, but may fin ... | 1977 | 321899 |
| immunotherapy of cancer. | clinical studies have indicated a close relationship between immunological competency and the growth of human cancer. studies in animal systems have indicated that immunological mechanisms are important in host-tumor existence. a number of agents are in the process of being evaluated for their immunotherapeutic potential in patients with cancer. these include levamisole, bacille calmette guérin (bcg) and corynebacterium parvum. while the precise role of these agents in the treatment of human mal ... | 1977 | 322390 |
| [treatment of solid tumours by intratumoral injection of immunostimulants]. | intra-lesional injections of immunostimulants--bcg or corynebacterium parpum--induced a local cure of the mcfifj2(s) tumour and a remote therapeutic effect. when applied to rats multigrafted with the mcfifi2(s) tumour, local and distant cures were obtained in some situations. this indicates the likely intervention of a specific immune mechanism. quantilating the pulmonary metastasis in combination with local treatment of lewis mouse tumours showed that bcg plus c. parvum injected into the tumour ... | 1977 | 322574 |
| functional heterogeneity in macrophages activated by corynebacterium parvum: characterization of subpopulations with different activities in promoting immune responses and suppressing tumor cell growth. | peritoneal cells (pec) from mice injected i.p. with heat-killed corynebacterium parvum (cp) showed enhanced immunostimulatory (accessor or a cell) activity as measured by their ability to restore the immune responsiveness of nonadherent spleen cells to sheep erythrocytes (srbc) and polymeric flagellin (pol) of salmonella adelaide in vitro. this was true whether the pec and nonadherent spleen cells were in direct contact or separated by a cell-impermeable membrane which allowed the free passage o ... | 1977 | 323353 |
| immunological properties of propionibacterium acnes. i. potentiation and suppression on antibody response to sheep and hamster erythrocytes in mice. | adjuvant activity of phenol-treated cells of propionibacterium acnes c-7 in antibody response was investigated in icr mice. simultaneous administration (day 0) of p. acnes (i.p.) and sheep red blood cells (srbc) (i.v.) enhanced the formation of direct plaque-forming cells (pfc) on days 2, and the formation of indirect pfc response on day 7 and thereafter. conversely, pretreatment from 11 to 14 days before antigen injection suppressed markedly the antibody response. the potentiation and the suppr ... | 1977 | 323645 |
| effects of bcg and corynebacterium parvum on the haemopoietic precursor cells in continuously irradiated mice: possible mechanisms of action in immunotherapy. | | 1977 | 324769 |
| effect of anti-thymocyte serum, anti-macrophage serum, and latex particles on the therapeutic efficacy of bcg or corynebacterium liquefaciens (propionibacterium acnes c7) in syngeneic mice. | in a syngeneic mouse-tumor system, anti-thymocyte serum, anti-macrophage serum, and latex particles were used for a comparative study of the immunotherapeutic efficacy of intradermal inoculation of tumor cell-bcg and tumor cell-corynebacterium liquefaciens (=propionibacterium acnes c7) vaccines. anti-thymocyte serum treatment nullified suppression of tumor mediated by bcg (living and nonliving) and living c. liquefaciens. however, the effect of nonliving c. liquefaciens was not affected so much ... | 1977 | 324858 |
| [growth of non-sporing anaerobes in an oxygen-free blood culture system (author's transl)]. | the efficacy of the commercially available vacutainer blood culture system to support the growth of non-sporing anaerobes was compared with two laboratory-prepared blood culture media (supplemented thioglycollate medium and brain heart infusion). the media were inoculated with 10, 100 and 1000 organisms of the species tested, and the number of colony-forming units was determined at intervals of 8-10 hrs. analogous experiments were performed with batches of the media to which 10% vol/vol of human ... | 1977 | 325956 |
| immunologic aspects of cancer chemotherapy. | | 1977 | 326163 |
| adjuvant activity of propionibacterium acnes isolated from the human oral cavity. | | 1977 | 326235 |
| resistance to parental, allogeneic and xenogeneic hemopoietic grafts in irradiated mice. | | 1977 | 326573 |
| superoxide dismutase in anaerobic bacteria of clinical significance. | twenty-two anaerobic bacteria isolated from infected sites and normal fecal flora were assayed for superoxide dismutase (sod). the organisms were also classified according to their oxygen tolerance into aerotolerant, intermediate, and extremely oxygen-sensitive groups. there was a correlation between the enzyme level and the oxygen tolerance, in that the aerotolerant and intermediate organisms had sod, whereas the extremely oxygen-sensitive isolates had low or undetectable enzyme. among the oxyg ... | 1977 | 326669 |
| complement activation by the alternative pathway and macrophage enzyme secretion in the pathogenesis of chronic inflammation. | a number of stimuli known to induce acid hydrolase secretion from cultured macrophages were examined for their ability to activate c3 via the alternative pathway of the complement system. loss of haemolytically active c3 was checked in normal and c4-deficient guinea-pig serum. for comparison the interactions of cultured macrophages with other agents well known as potent activators of the alternative pathway of the complement system have been investigated. as judged by their activity in these ass ... | 1977 | 328387 |
| adjuvant protection against bacterial infection in granulocytopenic mice. | the hypothesis that the induction of nonspecific resistance to infection by immunostimulation prior to drug-induced granulocytopenia would afford increased protection to subsequent bacterial challenge was tested in a murine model of infection with pseudomonas aeruginosa or staphylococcus aureus in mice rendered granulocytopenic with cyclophosphamide. prior intraperitoneal immunostimulation of mice with complete freund's adjuvant (cfa) or mycobacterium bovis (bacille calmette-guèrin; bcg) increas ... | 1977 | 328788 |
| mechanisms of action of immunopotentiating agents in cancer therapy. | | 1977 | 329658 |
| penetration of cells into millipore diffusion chambers. | | 1977 | 330180 |
| plasmodium yoelii and plasmodium vinckei: the effects of nonspecific immunostimulation on murine malaria. | | 1977 | 330190 |
| in vivo transfer of antitumor activity by peritoneal exudate cells from mice treated with corynebacterium parvum: reduced effect in irradiated recipients. | | 1977 | 330869 |
| management of metastatic breast cancer. | | 1977 | 330978 |
| canine migration inhibitory factor: effect of corynebacterium parvum administration. | peripheral blood lymphocytes from dogs sensitized to streptolysin o (slo) were assayed for migration inhibitory factor (mif) production by the indirect mif test, using guinea pig peritoneal exudate cells as the source of macrophages. a specific direct correlation was established between the degree of inhibition of migration and the concentration of slo-stimulated supernatants from lymphocyte cultures (slo-s) of untreated normal dogs. undiluted slo-s inhibited migration by 66.8%, whereas a diluti ... | 1977 | 332636 |
| corynebacterium parvum as the priming agent in the production of tumor necrosis factor in the mouse. | | 1977 | 333124 |
| [porphyrinsynthesis by propionibacterium acnes (author's transl)]. | strains of p.a. were isolated from seborrheic filaments from 11 persons and investigated according to their production of porphyrins. after growing the organisms during a 5 resp. 10 days cultivation period on solid as well as in liquid culture medium the quantity and quality of the bacterial porphyrins were determined. there existed intense variations in quantity not only when the special strains were compared with each other but also when the same strains were treated with different preparation ... | 1977 | 334087 |
| mechanism of corynebacterium parvum anti-tumour activity. ii. protective effect in t-cell-deprived mice. | the natural resistance to syngeneic mammary carcinoma was reduced by thymectomy alone in adult c3h mice or in mice thymectomized, lethally irradiated and restored with bone-marrow cells (tx rb). the protective effect of c. parvum was not modified by adult thymectomy but it was reduced in tx rb mice. the injection of thymic cells to tx rb mice or the elimination of t cell precursors in bone-marrow cells injected in tx rb mice did not increase the protective effect of c. parvum. these results were ... | 1977 | 334678 |
| immunotherapy in the treatment of cancer. | this article is a review of immunotherapy in the treatment of cancer incorporating the history of immunotherapy in the nineteenth and twentieth centuries, assessment of the techniques currently in use and of possible future developments. although immunotherapy is not established as a therapeutic technique, evidence suggests that the immune response does influence the development of neoplastic cells. a better understanding of the immune response and its control may lead to the production of effic ... | 1977 | 337486 |
| the reversal of established enhancement in rat cardiac allografts. | established enhancement in rat cardiac allografts was challenged in a variety of ways in an attempt to provoke rejection. incompatible skin grafts, injections of sensitised lymphocytes, and the administration of the macrophage-stimulating agent corynebacterium parvum proved ineffective. however, levamisole, which stimulates both macrophages and sensitised lymphocytes, caused rejection in four of a group of six as rats bearing enhanced (august x as)f1 hybrid heart allografts. a combination of c. ... | 1977 | 339437 |
| mechanism of nonspecific macrophage-mediated cytotoxicity: evidence for lack of dependence upon oxygen. | peritoneal macrophages elicited in c3h/hj mice by the i.p. injection of corynebacterium parvum were cytotoxic to allogeneic virus-transformed fibroblasts in vitro. cytotoxicity was demonstrated in a morphologic (plaque) assay, and quantitated by measuring macrophage-mediated inhibition of incorporation of 3h-thymidine by the target cells. the cytotoxic effect was well established by 6 hr of macrophage-fibroblast interaction, and was retained in cultures from which the supernatant was removed bef ... | 1978 | 340584 |
| suppression of natural killer cell cytotoxicity by splenocytes from corynebacterium parvum-injected, bone marrow-tolerant, and infant mice. | natural killer (nk) cell cytotoxicity to yac-1 lymphoma was investigated in mice tolerant to bone marrow grafts (bm-tolerant), corynebacterium parvum- (c. parvum) treated mice, and infant mice. also the comparison was made between the nk cell and the hemopoietic-resistance effector (hr-e) cells. it was found that the bm-tolerant mice and c. parvum-treated mice showed either no or markedly decreased nk cell cytotoxicity. these mice were also nonresponders to bone marrow grafts in vivo. the lack o ... | 1978 | 342602 |
| antitumor activity of corynebacterium parvum. | | 1978 | 343523 |
| the cells involved in the modification of the in vitro immune response by corynebacterium parvum (c. parvum). | | 1977 | 344096 |
| immunological adjuvants in cancer immunotherapy. | | 1977 | 344097 |
| host responses in adjuvant contact suppression of experimental rat tumours. | bcg (glaxo) and c. parvum (wellcome cn 6134) have been examined for suppression of growth of a range of syngeneically transplanted rat tumours, both carcinogen-induced and of spontaneous origin. treatment by locally applied adjuvant controlled growth of both immunogenic and non-immunogenic tumours, and the response to highly immunogenic tumours was not abolished by host immunosuppression with whole body irradiation known to abrogate induction of tumour-specific immunity. in addition, rat tumour ... | 1977 | 344098 |
| various modalities of local administration of bacterial immunostimulants in transplantable rat tumours and in primitive methylcholanthrene mouse tumours. | the frequent use of intra-lesional injection of bacterial immunostimulants is hampered by apparent rarity of susceptible tumours, absence of therapeutic effect on large tumours, lack of variety of experimental models, eventual traumatism which is feared in case of intra-lesional, and injection in visceral cancers. (1) methylcholanthrene induced primitive tumours in mice are more frequently susceptible when the carcinogen induction dosage is low (0.01 mg). (2) using transplantable rat tumours, on ... | 1977 | 344100 |
| monitoring of a multi-modal schedule for the treatment of disseminated breast cancer. | 39 women and 1 man have been monitored by sequential cea, immunoglobulin, lymphocyte and monocyte readings, hydroxyproline excretion, scans and x-rays. cea is shown to be a useful monitor of disease. the significance of the lymphocyte counts is discussed. | 1977 | 344101 |
| a phase i study of a multi-modal schedule with corynebacterium parvum. | a phase i study of an immuno-chemotherapy regime was carried out using c. parvum as an immune-modulator. 14 women were studied. all received doses of c. parvum ranging from 2.5 mg to 21 mg administered in 1 litre of dextrose saline over 4 h. no evidence of tumour enhancement was observed. | 1977 | 344102 |
| clinical trial with corynebacterium parvum. | corynebacterium parvum was administered to sixteen patients with malignant tumors submitted to repeated chemotherapy courses. a total of 428 injections of c. parvum at a dose of 3.5 mg/m2 in weekly, biweekly and monthly administration was given between the chemotherapy courses. injection of c. parvum was followed by fever and local pain in 15/16 patients. three patients presented a local ulceration during the initial period of weekly injections. splenomegaly was observed after the second month o ... | 1977 | 344103 |
| clinical experience in the use of c. parvum in the treatment of locally advanced carcinoma of the breast. | twenty-one patients with locally advanced breast cancer which had failed to respond to conventional therapy have been treated by infusion of c. parvum (strain cn 6134, wellcome research laboratories) in 5% dextrose. thirteen patients had a single dose of 15 mg. c. parvum over 4 h and 8 patients received 5 daily infusions of 4 mg c. parvum over 1 h. in 3 patients there was some evidence of tumour regression. pyrexia, often associated with rigors, headaches, vomiting and variations in blood pressu ... | 1977 | 344104 |
| clinical studies with corynebacterium parvum. | in a pilot study twelve patients with malignant disease were treated with corynebacterium parvum. the clinical results were encouraging. a prospective randomised controlled clinical trial of c. parvum therapy in the treatment of patients with carcinoma of the bronchus began in august 1976. 22 pateints have been admitted to the trial and 11 treated with c. parvum. clinical progress is reported. radiological, haematological, biochemical and immunological measurements have been made and these resul ... | 1977 | 344105 |
| randomized trial in advanced breast cancer using combination chemotherapy with or without c. parvum; preliminary results. | in a prospectively randomized cooperative study patients with metastatic breast cancer were treated with or without corynebacterium parvum (c.p.)5 mg/sc/m2 on day 1 in addition to cao/cmf (cyclophosphamid (c) 150 mg/m2/d per os x 5 d and adriamycine (a) 50 mg/m2 i.v. d 1 and oncovin (o) 1.0 mg/m2 i.v. d 1. 6 cao-cycles q 28 days later were followed by monthly cmf cycles q 28 d with cyclophosphamide (same dose), methotrexate 30 mg/m2 i.v. 1 and 5-fluorouracil 600 mg/m2 i.v. d 1). 76 patients ente ... | 1977 | 344108 |
| c. parvum clinical protocols: prototypes and summary results in u. s. trials with wellcome coparvax. | clinical investigations utilizing wellcome c. parvum in cancer therapy number more than one hundred in multiple institutions. multiple diseases in various stages are being attacked by multi-modality therapy, making the role of immunotherapy very difficult to assess. fundamental laboratory observations have suggested ways of weaving non-specific with specific immunotherapy, and these with chemotherapy and radiation to yield maximum therapeutic benefit. current protocols include examples of the cr ... | 1977 | 344109 |
| clinical immunotherapy experiences in the southeastern cancer study group. | the southeastern cancer study group has been particularly interested in the use of immunological adjuvants in the treatment of melanoma and acute myelogenous leukemia. a study of chemotherapy versus chemoimmunotherapy in randomly selected patients with metastatic malignant melanoma revealed no significant increase in either complete remissions or overall survival in the group receiving chemoimmunotherapy. preliminary results in a study involving maintenance of patients with acute myelogenous leu ... | 1977 | 344110 |
| immunotherapy from malignant disease. | | 1978 | 348035 |
| some examples of interactions between drugs in cancer chemotherapy. | drug combinations in cancer treatment are widely utilized because they frequently result in better therapeutic activity than the single treatments. the mechanism(s) by which this can be achieved may reside in an enhanced chemotherapeutic effect or in reduced toxicity, it being difficult to dissociate the two aspects. to underline this difficulty, experimental studies will be reported. a first example illustrates the interaction between phenobarbital and cyclophosphamide. depending on the schedul ... | 1978 | 348085 |
| combination chemotherapy plus methanol extracted residue of bacillus calmette-guérin or corynebacterium parvum in stage iii lung cancer. | seventy-six patients with stage iii bronchogenic carcinoma were treated with monthly adriamycin, cyclophosphamide, cis-dichlorodiammineplatinum(ii), and vincristine. in addition, they were randomized to receive either no immunotherapy, the methanol extracted residue of bacillus calmette-guérin (mer), or corynebacterium parvum (c. parvum). age, histology, extent of disease, prior therapy, and performance status were comparable in the three treatment groups. twelve patients (16%) died having recei ... | 1978 | 350388 |
| chemo-immunotherapy for unresectable bronchogenic carcinoma. | seventy-nine patients with metastatic or unresectable bronchogenic carcinoma were treated with a regimen of combination chemotherapy which included methotrexate, oncovin (vincristine), cyclophosphamide, and adriamycin (moca), and were randomized to receive no additional therapy, immunotherapy with bacillus calmette-guérin, or immunotherapy with corynebacterium parvum (c. parvum). the response rate and estimated median survival time were 68% and 42 weeks in small cell carcinoma and 18% and 29 wee ... | 1978 | 350397 |
| immunity to transplantable carcinogen-induced fibrosarcomas in b2/b2 chickens. i. use of bacterial adjuvants in induction of immunity demonstrable in winn tests. | | 1978 | 354799 |
| combination chemoimmunotherapy for extensive non-oat cell lung cancer. | in a prospective randomized trial, sc corynebacterium parvum (c. parvum) immunotherapy did not significantly affect the responses and survival of 49 non-oat cell lung cancer patients receiving isophosphamide and adriamycin chemotherapy. remissions (tumor regression greater than 50%) were seen in five of 23 patients receiving an intensive c. parvum schedule and in three of 26 patients receiving a nonintensive c. parvum schedule (22% versus 12%). median survival was 20 weeks for patients given int ... | 1978 | 356968 |
| the effect of intramural injection of immunotherapeutic agents on bladder histology and systemic humoral response. | bacillus calmette-guerín (bcg), corynebacterium parvum, and various mycobacterium fragments were injected intramurally into mouse bladders and the resulting systemic humoral stimulation and local histologic reactions were evaluated. c. parvum and methanol extracted residue of bcg elicited significant immunostimulation without producing irreversible bladder damage. the severe histologic disruption caused by bcg could be reduced by the antituberculus drug isoniazed without abrogating the humoral s ... | 1978 | 361626 |
| [immuno-chemotherapy in patients with disseminated metastasizing stage iii melanoma. randomized study with methyl-ccnu versus c. parvum plus methyl-ccnu]. | 34 patients with disseminated malignant melanoma (stage iii) were randomized to the following therapy groups: chemotherapy (meccnu, nsc 99441; 200 mg/m2, given orally every 8 weeks), or immuno-chemotherapy (1 mg corynebacterium parvum i.v., on days 1-4 + meccnu 200 mg/m2 on day 8, repeated every 7 weeks). total therapy response rate was 33%; total and partial remissions were achieved in 26% of the patients receiving chemotherapy, and in 40% under immuno-chemotherapy. interim life table analysis ... | 1978 | 362293 |
| multimodal immunotherapy of primary gastrointestinal tumors in rats. 1. histologic correlation. | the effect of multimodal immunotherapy was studied in rats bearing primary gastrointestinal tumors induced by 1,2-dimethylhydrazine dihydrochloride. multimodal immune manipulation consisted of combinations of splenectomy, c. parvum, unblocking serum, unblocked lymphoid cells, and levamisole. such immunologic intervention resulted in significant inhibition of tumor growth, and their metastasis. ten of 10 untreated rats, 8 of 8 rats treated with splenectomy alone and 10 of 10 rats treated with nor ... | 1978 | 363250 |
| immunomodulation by corynebacterium parvum. 1. variable effects on anti-sheep erythrocyte antibody responses. | corynebacterium parvum injected i.p. 1--16 days prior to i.p. antigen inoculation virtually abolished both igm and igg primary responses to 1 x 10(8) srbc. the suppression was significantly marked at antigen doses ranging from 1 x 10(6)--1 x 10(9) srbc but not at 5 x 10(9) srbc. as little as 56 microgram c. parvum caused a marked suppression of the response to 1 x 10(8) srbc. in secondary responses c. parvum given either one day before priming with 1 x 10(8) srbc or one day before secondary chal ... | 1978 | 363603 |
| cocarcinogenesis. | | 1979 | 367444 |
| [current status of immunotherapy of malignant tumors]. | | 1979 | 367730 |
| immunotherapy of solid tumor. | | 1979 | 375448 |
| defective tumoricidal capacity of macrophages from a/j mice. i. characterization of the macrophage cytotoxic defect after in vivo and in vitro activation stimuli. | macrophages from a/j mice fail to develop tumoricidal activity after any of several in vivo or in vitro treatments that activate cells from c3h/hen mice. peritoneal macrophages from a/j mice treated i.p. with viable mycobacterium bovis, strain bcg, killed corynebacterium parvum, or pyran copolymer fail to develop in vitro tumoricidal activity; varying the numbers of macrophages from treated mice added to target cells, or the dose and time of treatment, or the treatment schedule of these in vivo ... | 1979 | 376720 |
| in vitro killing of schistosomula of schistosoma mansoni by bcg and c. parvum-activated macrophages. | resistance to schistosoma mansoni infection in the mouse has been induced either specifically by a primary infection with this parasite or nonspecifically by a variety of immunostimulants such as bcg. in the present study we developed an in vitro system to examine the effector mechanism of nonspecifically induced resistance. activated macrophage monolayers obtained from bcg- or corynebacterium parvum treated mice killed a respective mean 32 +/- 6% and 48 +/- 5% of schistosomula after 24 hr incub ... | 1979 | 376723 |
| current state of clinical immunotherapy. | | 1979 | 377611 |
| effect of adriamycin and corynebacterium parvum in tumor-bearing mice: modulation of response to sheep red blood cells. | administration of adriamycin and corynebacterium parvum alone in c57bl/6j mice bearing lewis lung carcinoma stimulated the direct (19s) and indirect (7s) plaque-forming cell (pfc) response specific for sheep red blood cells. thus adriamycin appears to possess some immunostimulatory effect on tumor-bearing mice with much less effect than c. parvum alone. simultaneous administration of adriamycin and c. parvum decreased the pfc response compared to that for c. parvum alone. this decrease may indic ... | 1979 | 379400 |
| corynebacterium parvum: effects on the biochemistry of mouse serum and liver. | | 1979 | 379402 |
| subcutaneous corynebacterium parvum in bladder cancer: a controlled study of its immunological effects. | fourteen out of 26 patients with invasive bladder cancer were randomly assigned to receive weekly subcutaneous injections of corynebacterium parvum (cp) in addition to standard treatment. peripheral blood t lymphocyte percentage, k cell activity, mitogen responsiveness, and monocyte and polymorph leucotaxis were measured at intervals over a period of 1 to 2 years. the only consistent difference between the cp-treatment patients and the controls was a slightly higher level of k cell activity in t ... | 1979 | 380732 |
| cyclophosphamide plus 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide (dtic) with or without corynebacterium parvum in metastatic malignant melanoma. | one hundred twenty patients with metastatic malignant melanoma were randomized to receive either cyclophosphamide, 600 mg/m2 iv, on day 1 plus dtic 200 mg/m2 iv days 1 through 5, or the same chemotherapy plus c. parvum 5 mg/m2 iv on day 8 and day 15. therapy was repeated every 21 days. although responses were observed in 13.8% of patients on cyclophosphamide plus dtic versus 25.5% of patients on cyclophosphamide plus dtic plus c. parvum, the median duration of remission was 15.6 weeks on chemoth ... | 1979 | 383276 |
| c. parvum treatment of transplanted rat tumours of spontaneous origin. | c. parvum (wellcome cn6134) has been examined for suppression of a range of transplanted rat tumours of spontaneous origin. with five tumours (three mammary carcinomas and two fibrosarcomas) growth of comparatively high cell inocula (with respect to the minimum for growth in control rats) was suppressed by admixture with the vaccine. equivalent dry weights of glaxo, pasteur or connaught bcgs were relatively ineffective. intralesional injection of c. parvum into three three established tumours (t ... | 1979 | 385514 |
| direct effects of corynebacterium parvum and bcg on human monocyte-mediated tumour cell cytostasis in vitro. | four strains of corynebacterium parvum (cp) and bcg induced low levels of cytostatic ability to a human tumour cell line in human monocytes when added directly to conventional monocyte cultures. the cytostatic ability induced by mediators from autologous lymphocytes stimulated with the same agents was greater than that produced by direct addition to monocytes. bcg was more efficient in stimulating lymphocyte dna-synthesis and lymphokine release than any of the cp strains tested. in order to test ... | 1979 | 386712 |
| prostaglandin-like substances in propionibacterium acnes. iii. differential contractile effects on smooth muscle layers of the human utero-tubal junction. | the biological activity of a lipid fraction extracted from p. acnes was tested on isolated smooth muscle strips from the human utero-tubal junction. the bioassay experiments support the concept that prostaglandin-like substances (pls) occur in p. acnes. however, in the bioassay system used, the effect of pls was different from that of pgf2 alpha and pgi2 but similar, although not identical, to that of arachidonic acid and pge2. | 1979 | 387431 |
| [protection of mice with bacterial phospholipids against the lethal effect of frog virus 3 (fv 3) (author's transl)]. | a bacterial phospholipid extract (ebp) inoculated intraveinously at a dose of 1 mg/25 g body weight 30 hours before infection protects mice against the lethal effect of frog virus 3 (fv 3). the anti-fv 3 resistance produced by ebp requires protein synthesis during the period of pretreatment. the treatment with the bacterial extract has no effect on the inhibition of the macromolecular synthesis of the liver (rna and dna) which is observed at the beginning of the infection. however 48 hours after ... | 1979 | 388298 |
| the effect of bcg-vaccination on vaccinia virus infections in mice. | pretreatment with bcg yielded a high degree of protection against experimental vaccinia virus infections in mice. corynebacterium parvum and aristolochia acid were less protective; other immunostimulants were ineffective. | 1979 | 389657 |
| the effect of acidic polysaccharides and prostaglandin-like substances isolated from propionibacterium acnes on granulocyte chemotaxis. | three acidic polysaccharide (ap) fractions and the prostaglandin-like substances (pls) isolated from p. acnes were investigated regarding their chemotactic activities on polymorphonuclear leukocytes. both ap's and pls induced a significant chemotatic response, which suggests their involvement in inflammatory acne vulgaris. | 1979 | 391585 |
| chemoimmunotherapy (dtic and corynebacterium parvum) as adjuvant treatment in malignant melanoma. | sixty-one patients with stage i or ii (lymph node involvement) malignant melanoma were prospectively randomized into a control group receiving surgical treatment only (consisting of wide excision of primary and regional node dissection) and a group receiving the same surgical treatment plus adjuvant therapy with dtic and corynebacterium parvum. followup times ranged from 1 1/2 to 4 years. among the 29 patients in the surgical control group, there were five hematogenous recurrences and one region ... | 1979 | 393377 |
| immunotherapy of lung cancer. i. review of clinical trials in non-small cell histologic types. | | 1979 | 394836 |
| antitumor activity of cell-wall skeleton of propionibacterium acnes c7 in mice and guinea pigs. | the antitumor activity of the cell-wall skeleton (cws) of propionibacterium acnes c7 was examined by using transplantable tumors in syngeneic mice and in guinea pigs, and autochthonous tumors in mice. p. acnes-cws was shown to suppress the growth of fibrosarcomas, el4 leukemia, and mh134 hepatoma in syngeneic mice, and to regress the established tumors of a fibrosarcoma (mc104) in c57bl/6j mice, and a hepatoma (line-10) in strain-2 guinea pigs. the oil-attached p. acnes-cws mixed with fructose m ... | 1979 | 395008 |
| human monocyte-mediated cytotoxicity to k-562 cells: activation by lymphokines. | human monocytes purified by adherence and prolonged in vitro monolayer culture were activated by supernatants of autologous lymphocytes stimulated with live bacillus calmette-guérin or killed corynebacterium parvum. activated monocytes expressed increased ability to lyse k-562 cells prelabelled with methyl-3h-thymidine in a 48 h assay. activation could be detected at a 1:64 dilution of lymphokine supernatants. target cell killing by activated monocytes was strongly influenced by the density of t ... | 1979 | 396667 |
| influence of tumor burden, tumor removal, immune stimulation, plasmapheresis on monocyte mobilization in cancer patients. | | 1979 | 397757 |
| immune response modulation by colonization of germfree rats with propionibacterium acnes. | propionibacterium acnes (oral and/or parenteral administration) had a modulating effect on antibody-and cell-mediated immune responses of germfree (gf) and monoassociated (ma) rats. in conventionally reared rodents, parenteral injection of killed p. acnes stimulated the splenic plaque-forming cell response to sheep erythrocytes. however, in gf rats and in rats monoassociated with viable p. acnes, parenteral injection of killed p. acnes antigen inhibited the plaque-forming cell response to sheep ... | 1979 | 397928 |