| pyruvate, orthophosphate dikinase of bacteroides symbiosus and propionibacterium shermanii. | | 1975 | 237180 |
| quantitative microbiology of the scalp in non-dandruff, dandruff, and seborrheic dermatitis. | the composition of the scalp microflora was assessed quantitatively in normal individuals and in patients with dandruff and seborrheic dermatitis, disorders characterized by increasing scaling. three organisms were constantly found: (1) pityrosporum, (2) aerobic cocci, and (3) corynebacterium acnes. pityrosporum (mainly pityrosporum ovale) made up 46% of the total microflora in normals, 74% in dandruff, and 83% in seborvheic dermatitis. the geometric mean number of organisms per cm-2 in non-dand ... | 1975 | 237965 |
| analysis of lipid composition of isolated human sebaceous gland homogenates after incubation with cutaneous bacteria. thin-layer chromatography. | the effects of specific species of skin bacteria on human sebaceous gland lipids in vitro were analyzed. isolated dissected sebaceous glands were pooled, homogenized, and sterilized, then incorporated into peptone-yeast extract medium and used as substrate for growth of propionibacterium acnes, p. granulosum, and staphylococcus epidermidis subgroup ii. the sebaceous lipids were analyzed by thin-layer chromatography before and after bacterial growth. the most striking effect of bacteria on sebace ... | 1975 | 237966 |
| the localization and distribution of gram-positive cocci in normal skin and in lesions of acne vulgaris. | the localization of gram-positive cocci in the normal skin and in the lesions of acne vulgaris was investigated using fluorescein-labeled antiserum raised to gram-positive, coagulase-negative cocci. the cocci were found in 10 of 19 specimens from normal facial skin and in 3 of 11 specimens from the normal skin of the rest of the body. the bacteria were found mostly in the openings of follicles, but in 6 of 10 facial skin specimens, they were also present deeply in the lumina of the dilated sebac ... | 1975 | 239073 |
| [ribonucleotide reductase in propionibacterium shermani]. | the cell-free extract of propionibacterium shermanii was found to contain b12-dependent ribonucleotide reductase. the extract of the cells grown under the conditions of the inhibited synthesis of vitamin b12 reduces ribonucleotides with the participation of b12-independent enzyme. the synthesis of b12-dependent apoenzyme of ribonucleotide reductase is partially maintained under these conditions. both enzymes reduce preferably ribonucleoside diphosphates. the reducing agent of nucleotides in vitr ... | 1975 | 241003 |
| control of surgical nosocomial infections. | | 1978 | 249627 |
| [histopathological aspects and macrophage reactivity in rats with guerin's t8 viral tumor after treatment with corynebacterium parvum]. | | 1979 | 262125 |
| liver abscess in normal children with fever of unknown origin. | | 1978 | 263854 |
| susceptibility of various microorganisms to chlorhexidine. | the susceptibility to chlorhexidine of bacteria in aerobic, facultatively anaerobic and anaerobic isolates from clinical specimens of wounds, urine, saliva, and dental plaque was studied. agar diffusion tests using 50 microng chlorhexidine discs and agar dilution tests were performed and the mic values correlated with inhibition zone diameters. anaerobic plaque strains were isolated and tested by the agar dilution method in an anaerobic glove box. regression lines obtained for five agar media de ... | 1977 | 266752 |
| tumor immunology of experimental osteosarcoma. | a spontaneous ap positive c3h murine os was used to determine the effects of various treatment modalities. ap served as a useful circulating biomarker of the in vivo tumor growth. in animals whose tumor was amputated, the elevation of the marker indicated the presence of pulmonary metastases. it was used to establish the time of recurrence after a partially effective chemotherapy or combination modality. in this model, when the neoplasm was surgically excised at 10 days posttransplantation, 70-- ... | 1978 | 278687 |
| effect of corynebacterium parvum on tumor growth in the central nervous system of mice. | | 1978 | 278860 |
| propionibacterium acnes-mediated humoral immune responses to tumor-specific antigens on rat liver cells transformed in vitro by chemical carcinogens. | effects of propionibacterium acnes on production of antibodies against tumor-specific membrane antigens were investigated in syngeneic inbred bd iv and bd vi rats. bd rat liver cell lines transformed in vitro by chemical carcinogens were used as target cells for tumor-specific antigens. by membrane immunofluorescence, antibodies against these rat liver cell lines were detected in syngeneic bd rat sera. antibodies were produced in syngeneic rats under the adjuvant effect of heat-killed p. acnes o ... | 1978 | 281560 |
| tumor growth inhibition and potentiation of immunotherapy by indomethacin in mice. | indomethacin was continuously administered in the drinking water of inbred c3h mice given grafts of syngeneic 3-methylcholanthrene-induced fibrosarcomas. a minor proportion of these animals died at the same time as the untreated controls, and others completely rejected their tumors; however, in most cases, the tumor growth rate was significantly slowed, and growth recommenced rapidly after drug withdrawal. this was the pattern for tumors either in their 10th to 14th transplant generation or only ... | 1979 | 281566 |
| in vivo antitumor activity of various forms of delayed-type hypersensitivity in mice. | relationships among various forms of delayed-type hypersensitivity (dth) and nonspecific resistance to lewis lung tumor were studied in syngeneic and semisyngeneic mice. only the tuberculin type of dth obviated a virulent inoculum of 10(6) tumor cells. the jones-mote type of dth, even modified by cyclophosphamide pretreatment, produced a significant local inflammatory reaction which was unable to destroy tumor cells. the antitumor effect of the tuberculin type was observed in bcg-or in corynbact ... | 1979 | 283275 |
| experimental transient bacteraemias in human subjects with clinically healthy gingivae. | thirty-six subjects with no evidence of clinical gingival inflammation underwent a standardized toothbrushing procedure. blood specimens, obtained from a vein in the antecubital fossa during the last 30 seconds of brushing, were cultured under aerobic and stringent anaerobic conditions. three subjects exhibited detectable bacteraemias, propionibacterium sp. being isolated from two of the subjects, while actinomyces sp., streptococcus sanguis and streptococcus mitis were isolated from the third. ... | 1979 | 285080 |
| further observations on the inhibition of tumor growth by corynebacterium parvum with cyclophosphamide. ix. macrophage content of tumors in mice. | | 1979 | 285276 |
| radiation-induced osteogenic sarcoma of c3h mouse: effects of corynebacterium parvum and wbi on its natural history and response to irradiation. | | 1979 | 285860 |
| further observations on the inhibition of tumor growth by corynebacterium parvum with cyclophosphamide. x. effect of treatment on tumor cell kinetics in mice. | | 1979 | 286125 |
| an evaluation of corynebacterium parvum during remission maintenance therapy in pediatric patients with acute lymphoblastic leukemia. | the biologic impact and clinical toxicity of corynebacterium parvum administered at a dose of 5 mg/m2 by intravenous or subcutaneous routes were evaluated in 18 children receiving combination chemotherapy for maintenance of acute lymphoblastic leukemia (all) in remission. several nonspecific immunologic and hematologic parameters were evaluated. patients were also monitored for changes in cutaneous sensitivity to histamine. no changes in any parameter were observed in patients after only one cou ... | 1979 | 287855 |
| bacteriocin (acnecin) activity of oral propionibacterium acnes. | | 1978 | 291496 |
| effect of host immune capability on radiocurability and subsequent transplantability of a murine fibrosarcoma. | | 1979 | 291749 |
| effect of corynebacterium parvum and chronic toxoplasma infection on metastatic brain tumors in mice. | | 1979 | 291750 |
| [delayed toxicity of bacterionema matruchotii (author's transl)]. | | 1979 | 298036 |
| [initial experiences with a nation-wide austrian study of adjuvant chemo- and immunotherapy of colorectal cancer following radical surgery]. | the outline of a cooperative study for adjuvant chemo-immunotherapy on radically operated colon-rectum-carcinoma, is presented. one group of patients receiving placebo, has to be randomized against another group who postoperatively received chemo-immunotherapy consisting of 5-fluorouracil and ccnu and corynebacterium parvum, which was administered intermittently, throughout one year. patients with rectum-carcinoma additionally receive radio-therapy with 1500 rad hd before surgery and 4500--5000 ... | 1979 | 299221 |
| the adjuvant effect of corynebacterium parvum: t-cell dependence of macrophage activation. | splenic and peritoneal macrophages from mice treated with corynebacterium parvum enhanced the antibody response in vitro of normal nonadherent spleen cells to srbc, but not to dnp-pol. this enhancement was dependent on the dose and time of administration of c. parvum and could be abrogated by pretreatment with carrageenan. macrophages from t-cell-depleted mice failed to enhance the response, but this ability was restored if the mice had been reconstituted with purified t lymphocytes. macrophages ... | 1977 | 299769 |
| effect of corynebacterium parvum on tumor growth in normal and athymic (nude) mice. | the effect of systemic or local injection of corynebacterium parvum at the tumor site on the growth of various murine tumors was studied in intact and congenitally athymic balb/c mice. systemic injection of c. parvum usually had a marked antitumor effect in both types of mouse. two lymphomas, which regressed spontaneously in untreated intact mice but not in athymic mice, grew progressively in intact mice given systemic c. parvum, though their growth was inhibited in similarly treated athymic mic ... | 1977 | 299893 |
| in vitro antitumor effect of lymphoid cells from corynebacterium parvum-treated mice: effect of route of c. parvum administration. | corynebacterium parvum administration in cba mice resulted in the stimulation in the peritoneal exudate and other lymphoid organs of cells which nonspecifically inhibited the tumor growth in vitro. the distribution of the antitumor activity in different organs was dependent on the route of c. parvum injection. both ip and iv treatments stimulated antitumor activity in the peritoneal exudate, whereas the sc route was ineffective. only iv treatment stimulated the antitumor activity in the blood, ... | 1977 | 300113 |
| [is immunotherapy useful in bronchial carcinoma?]. | | 1977 | 300502 |
| effect of corynebacterium parvum on colony-stimulating factor and granulocyte-macrophage colony formation. | because corynebacterium parvum has tumor-inhibitory properties and stimulates granulocyte-macrophage production, it may have clinical value in combination with chemotherapy. the leukopoietic effect of killed suspensions of c. parvum was studied in mice using the technique of in vitro clonal culture of hematopoietic cells. after c. parvum injection, there was a prompt, sustained elevation of serum colony-stimulating factor followed by an increase in granulocyte-macrophage precursor cells in the s ... | 1977 | 300651 |
| immunotherapy of cancer. | | 1977 | 301988 |
| altered toxicity of 5-fluorouracil following treatment with corynebacterium parvum. | recent studies have demonstrated that systemic corynebacterium parvum increases serum granulocyte-macrophage colony-stimulating factor and stimulates the proliferation of granulocyte-macrophage progenitor cells. it was hypothesized that more rapid cycling of granulocyte-macrophage progenitor cells would render the cells more sensitive to a cell cycle-specific chemotherapeutic agent. the colony-forming ability of bone marrow granulocyte-macrophage progenitor cells was assayed in vitro with soft a ... | 1978 | 304762 |
| [the so-called adjuvant corynebacterium parvum]. | | 1978 | 304802 |
| colony stimulating and inhibiting activities in mouse serum after corynebacterium parvum-endotoxin treatment. | | 1978 | 304892 |
| suppression of rat t cell proliferation by corynebacterium parvum: t cell requirement for induction. | | 1978 | 304893 |
| effects of corynebacterium parvum on granulocyte/macrophage production and toxicity of chemotherapy. | | 1977 | 305373 |
| a role for t lymphocytes in the antitumour action of systemic c. parvum. | the frequency of tumours arising from s.c. injection of a syngeneic chemically-induced fibrosarcoma (fsa) was not influenced by systemic administration of c. parvum (day + 3) except when doses less than the td50 were injected. then the number of takes was increased. the tumour normally grows progressively however regression was frequent in intact mice treated with c. parvum. tumour regression did not occur in t cell-depleted mice treated in the same way. splenic t cell-enriched populations of ce ... | 1977 | 305374 |
| possible mechanisms in the anti-tumour activity of c. parvum. | normal murine peritoneal macrophages exhibited anti-tumour cytotoxicity following simultaneous incubation with c. parvum and lymphoid cells from c. parvum-treated mice. both t- and b-lymphocytes appear to be involved in this macrophage activation which is mediated by a soluble factor(s) released by immune lymphoid cells in response to the specific immunising strain of c. parvum. cells capable of macrophage activation do not appear until 6 days following systemic c. parvum administration despite ... | 1977 | 305375 |
| [immunotherapy of malignant diseases. a way towards the goal?]. | | 1978 | 305530 |
| induction of interferon production in mouse spleen cell cultures by corynebacterium parvum. | | 1978 | 307432 |
| a role for t lymphocytes in tumour inhibition and enhancement caused by systemic administration of corynebacterium parvum. | | 1978 | 308542 |
| effect of corynebacterium parvum on human t-lymphocyte interferon production and t-lymphocyte proliferation in vitro. | | 1978 | 309789 |
| inhibition of memory cell-mediated cytotoxic response by systemic administration of corynebacterium parvum. | | 1979 | 311692 |
| immune function determination in patients with bladder cancer. | patients with bladder cancer were evaluated clinically for immune responsiveness and stage of disease. a battery of tests is described that attempts to correlate stage of disease with immune responsiveness. | 1978 | 311893 |
| separation of functionally distinct subpopulations of corynebacterium parvum-activated macrophages with predominantly stimulatory or suppressive effect on the cell-mediated cytotoxic t cell response. | | 1979 | 312146 |
| effects of corynebacterium parvum and bcg therapy on immune parameters in patients with disseminated melanoma. a sequential study over 28 days. ii. changes in non-specific (nk, k and t cell) lymphocytoxicity and delayed hypersensitivity skin reactions. | c. parvum and bcg produced significant changes in nk, k and t cell lymphocytotoxicity using a chang liver target cell. a consistent temporal pattern over 28 days of early depression, recovery, overshoot and then decline was described. this was particularly marked for c. parvum and 'k' cell activity. skin test reactivity to recall antigens at 28 days was not appreciably different from the pre-immunization reactivity. the importance of using lymphocyte concentration-cytotoxicity titration curves a ... | 1979 | 312169 |
| anaerobic and aerobic bacteriology of acute conjunctivitis. | aerobic and anaerobic cultures and clinical data were obtained from 131 patients presenting with acute conjunctivitis. similar cultures were obtained from 60 noninflamed individuals. anaerobes were isolated from 66 patients, 51 times in mixed culture with aerobes and 15 times (11.5%) as the only isolates. aerobes only were recovered in 54 patients. the organisms found to be statistically significantly more commonly recovered from eyes with conjunctivitis were staphylococcus aureus, hemophilus in ... | 1979 | 313179 |
| immunologic evaluation of patients with advanced head and neck cancer receiving weekly chemoimmunotherapy. | patients with advanced head and neck cancer have significant reduction in their circulating lymphocyte mass which is reflected in decreased numbers of t cells, fc receptor cells, and in derangements of t lymphocyte functions, i.e., decreased responsiveness to several dilutions of phytohemagglutinin and lack of development of delayed hypersensitivity to 2,4-dinitrochlorobenzene (70% of patients were dncb (-)). a population of phagocytic cells capable of decreasing lymphocyte responsiveness to mit ... | 1979 | 313240 |
| a trial of 5-fluorouracil and corynebacterium parvum in advanced colorectal carcinoma. | this study has confirmed that patients who have advanced colorectal carcinoma have impaired responsiveness to delayed-hypersensitivity skin testing, and also have elevated levels of serum igm. serial observations of delayed-hypersensitivity skin tests, total lymphocyte counts, t-lymphocyte counts, b-lymphocyte counts, and serum immunoglobulin levels failed to reveal any consistent pattern of responses in patients treated with either chemotherapy alone or chemoimmunotherapy. in 33 patients chosen ... | 1979 | 313873 |
| antigenic bacterial polysaccharide in rheumatoid synovial effusions. | phenol-water extracted rheumatoid synovial fluids and synovial fluid leukocytes contain an antigen immunologically identical to the proprionibacterium group bacteria. the antigen was identified by counter-immunoelectrophoresis in 70% of rheumatoid synovial fluid leukocyte pellets and in 60% of rheumatoid synovial fluids. it was also present in 6% of nonrheumatoid fluids and in 22% of nonrheumatoid inflammatory fluid leukocytes. antigen was not detectable in synovial samples before extraction. sy ... | 1979 | 314293 |
| effects of repeated corynebacterium parvum and bcg therapy on immune parameters: a weekly sequential study of melanoma patients. i. changes in non-specific (nk, k and t cell) lymphocytotoxicity, peripheral blood counts and delayed hypersensitivity reactions. | increased lymphocyte cytotoxicity, particularly of 'killer' k cell type was recorded with repeated immunizations of either c. parvum or bcg. a 3 week interval between immunizations was capable of maintaining the increase in cytotoxicity. no marked alterations of 'recall' skin hypersensitivity reactions nor of peripheral blood counts were noted. expression of cytotoxicity results as percentage 51cr release, lytic units/ml and cytotoxic capacity (after logit transformation of the cytotoxicity-lymp ... | 1979 | 314367 |
| stimulation of phosphatidylinositol turnover in the macrophage plasma membrane: a possible mechanism for signal transmission. | | 1979 | 315365 |
| [preliminary considerations on the intravenous use of corynebacterium parvum in the treatment of solid neoplasms]. | | 1979 | 315598 |
| value of immune monitoring in gynecologic cancer patients receiving immunotherapy. | immunotherapy with nonspecific immunopotentiators such as corynebacterium parvum is under study in several areas of gynecologic oncology. the efficacy of this new modality awaits the results of carefully done clinical trials designed to measure an improved effect on survival when this and similar agents are added to conventional therapy. this report deals with an attempt to demonstrate enhancement of the cell-mediated immune response in a small number of patients with advanced ovarian (18 patien ... | 1979 | 315714 |
| association of host immunoglobulins with solid tumours in vivo. | using a direct radioimmune antiglobulin technique and a competitive double-antibody radioimmune assay, we have demonstrated the presence of appreciable amounts of host immunoglobulins on the surface and in extracts of cell suspensions from freshly excised solid tumours. iga appeared to have the greatest concentrations from freshly excised solid tumours. iga appeared to have the greatest concentration, followed in turn by igm congruent to igg2a greater than igg1 congruent to igg2b greater than ig ... | 1979 | 315785 |
| [the bacteriological and biological significance of propionibacterium acnes--the indigenous bacteria of human skin. iv. age-related change in antibody to p. acnes in normal human sera (author's transl)]. | | 1979 | 316030 |
| effects of endotoxin and extracts of pregnant mouse uterus on the recovery of hemopoiesis after 5-fluorouracil. | a single injection of endotoxin, 4 hours after administration of 150 mg/kg of 5-fluorouracil (5-fu), stimulated the recovery of bone marrow hemopoietic cells that form colonies in spleen (cfu-s) or in culture (gm-cfc), of erythropoiesis, and of platelet production. corynebacterium parvum injections had similar effects. endotoxin-free extracts of tissues (from pregnant mouse uterus, placenta, and embryo) which have a high content of the factor(s) capable of stimulating growth of gm-cfc in vitro a ... | 1979 | 316724 |
| inhibition of host resistance by nutritional hypercholesteremia. | previous experiments showed that nutritionally induced hypercholesteremia in mice caused an increase in susceptibility to coxsackievirus b, with a marked suppression of cellular infiltrates in infected tissues and an increased mortality. the present studies demonstrated that a hypercholesteremic diet was associated with an inhibition in host resistance as measured by susceptibility to listeria monocytogenes infection and the growth of two transplanted syngeneic murine tumors. moreover, the abili ... | 1979 | 317596 |
| response of lympho-hemopoietic tissue to corynebacterium parvum by study of dna enzymes and h3-tdr metabolism. | the effects of corynebacterium parvum on the lymphohemopoietic tissues of mice was investigated by h3-tdr metabolism, organ weights, dna-polymerase-alpha activity and terminal deoxynucleotidyl transferase (tdt) activity. marked increase in spleen size occurred. the increase in size was accompanied by increases in dna-p-alpha activity and h3tdr uptake. this indicated that the spleen was a major site of cell proliferation and of increase in population size after c. parvum stimulation. thymus and b ... | 1979 | 317898 |
| inhibitory effect of propionibacterium acnes on the growth on syngeneic tumor transplants in nude mice. | | 1979 | 318050 |
| a comparison of the malate dehydrogenase of the propionic acid bacteria with the mammalian soluble and mitochondrial isoenzymes. | 1. like the malate dehydrogenases of eucaryotic cells, the propionibacterium shermanii enzyme is a dimer consisting of two 35,000 molecular weight subunits. 2. in electrophoretic behavior, resistance to substrate inhibition and stability to heating and dilution the p. shermanii mdh is more similar to the s-mdh than to the m-mdh of pig heart. 3. the p. shermanii mdh has a high turnover number (ca. 140,000) as well as km values for both l-malate and oxalacetate which are four times higher than the ... | 1978 | 318344 |
| a comparison of pyrogenicity and related properties seen in a suspension of corynebacterium parvum and a gramnegative organism. | when the pyrogenic properties of c. parvum and a gramnegative organism, s. typhimurium, were compared it was found that the onset of the pyrogenic response to c. parvum was delayed relative to that of s. typhimurium and that secondary responses rarely occurred. in further experiments the interaction of c. parvum and s. typhimurium was studied. although synergism was not demonstrated, the kinetics of the response to mixtures of the two vaccines was anomalous while pre-treatment of rabbits with c. ... | 1977 | 320069 |
| tumor immunology and immunotherapy. | tumor cells contain a variety of antigens, including tumor associated antigens. the tumor associated antigens can be clinically useful as markers for detection of cancer and some may also mediate host resistance against tumor growth. much emphasis has been placed on the detection of circulating tumor associated markers, with radioimmunoassays for carcinoembryonic antigen (cea) being extensively utilized. at present, cea does not appear to be promising for initial detection of cancer, but may fin ... | 1977 | 321899 |
| immunotherapy of cancer. | clinical studies have indicated a close relationship between immunological competency and the growth of human cancer. studies in animal systems have indicated that immunological mechanisms are important in host-tumor existence. a number of agents are in the process of being evaluated for their immunotherapeutic potential in patients with cancer. these include levamisole, bacille calmette guérin (bcg) and corynebacterium parvum. while the precise role of these agents in the treatment of human mal ... | 1977 | 322390 |
| [treatment of solid tumours by intratumoral injection of immunostimulants]. | intra-lesional injections of immunostimulants--bcg or corynebacterium parpum--induced a local cure of the mcfifj2(s) tumour and a remote therapeutic effect. when applied to rats multigrafted with the mcfifi2(s) tumour, local and distant cures were obtained in some situations. this indicates the likely intervention of a specific immune mechanism. quantilating the pulmonary metastasis in combination with local treatment of lewis mouse tumours showed that bcg plus c. parvum injected into the tumour ... | 1977 | 322574 |
| functional heterogeneity in macrophages activated by corynebacterium parvum: characterization of subpopulations with different activities in promoting immune responses and suppressing tumor cell growth. | peritoneal cells (pec) from mice injected i.p. with heat-killed corynebacterium parvum (cp) showed enhanced immunostimulatory (accessor or a cell) activity as measured by their ability to restore the immune responsiveness of nonadherent spleen cells to sheep erythrocytes (srbc) and polymeric flagellin (pol) of salmonella adelaide in vitro. this was true whether the pec and nonadherent spleen cells were in direct contact or separated by a cell-impermeable membrane which allowed the free passage o ... | 1977 | 323353 |
| immunological properties of propionibacterium acnes. i. potentiation and suppression on antibody response to sheep and hamster erythrocytes in mice. | adjuvant activity of phenol-treated cells of propionibacterium acnes c-7 in antibody response was investigated in icr mice. simultaneous administration (day 0) of p. acnes (i.p.) and sheep red blood cells (srbc) (i.v.) enhanced the formation of direct plaque-forming cells (pfc) on days 2, and the formation of indirect pfc response on day 7 and thereafter. conversely, pretreatment from 11 to 14 days before antigen injection suppressed markedly the antibody response. the potentiation and the suppr ... | 1977 | 323645 |
| effects of bcg and corynebacterium parvum on the haemopoietic precursor cells in continuously irradiated mice: possible mechanisms of action in immunotherapy. | | 1977 | 324769 |
| effect of anti-thymocyte serum, anti-macrophage serum, and latex particles on the therapeutic efficacy of bcg or corynebacterium liquefaciens (propionibacterium acnes c7) in syngeneic mice. | in a syngeneic mouse-tumor system, anti-thymocyte serum, anti-macrophage serum, and latex particles were used for a comparative study of the immunotherapeutic efficacy of intradermal inoculation of tumor cell-bcg and tumor cell-corynebacterium liquefaciens (=propionibacterium acnes c7) vaccines. anti-thymocyte serum treatment nullified suppression of tumor mediated by bcg (living and nonliving) and living c. liquefaciens. however, the effect of nonliving c. liquefaciens was not affected so much ... | 1977 | 324858 |
| [growth of non-sporing anaerobes in an oxygen-free blood culture system (author's transl)]. | the efficacy of the commercially available vacutainer blood culture system to support the growth of non-sporing anaerobes was compared with two laboratory-prepared blood culture media (supplemented thioglycollate medium and brain heart infusion). the media were inoculated with 10, 100 and 1000 organisms of the species tested, and the number of colony-forming units was determined at intervals of 8-10 hrs. analogous experiments were performed with batches of the media to which 10% vol/vol of human ... | 1977 | 325956 |
| immunologic aspects of cancer chemotherapy. | | 1977 | 326163 |
| adjuvant activity of propionibacterium acnes isolated from the human oral cavity. | | 1977 | 326235 |
| resistance to parental, allogeneic and xenogeneic hemopoietic grafts in irradiated mice. | | 1977 | 326573 |
| superoxide dismutase in anaerobic bacteria of clinical significance. | twenty-two anaerobic bacteria isolated from infected sites and normal fecal flora were assayed for superoxide dismutase (sod). the organisms were also classified according to their oxygen tolerance into aerotolerant, intermediate, and extremely oxygen-sensitive groups. there was a correlation between the enzyme level and the oxygen tolerance, in that the aerotolerant and intermediate organisms had sod, whereas the extremely oxygen-sensitive isolates had low or undetectable enzyme. among the oxyg ... | 1977 | 326669 |
| complement activation by the alternative pathway and macrophage enzyme secretion in the pathogenesis of chronic inflammation. | a number of stimuli known to induce acid hydrolase secretion from cultured macrophages were examined for their ability to activate c3 via the alternative pathway of the complement system. loss of haemolytically active c3 was checked in normal and c4-deficient guinea-pig serum. for comparison the interactions of cultured macrophages with other agents well known as potent activators of the alternative pathway of the complement system have been investigated. as judged by their activity in these ass ... | 1977 | 328387 |
| feasibility of thin layer chromatography as an inexpensive alternative to gas-liquid chromatography for the identification of some anaerobic gram positive non-sporing rods. | | 1977 | 328476 |
| adjuvant protection against bacterial infection in granulocytopenic mice. | the hypothesis that the induction of nonspecific resistance to infection by immunostimulation prior to drug-induced granulocytopenia would afford increased protection to subsequent bacterial challenge was tested in a murine model of infection with pseudomonas aeruginosa or staphylococcus aureus in mice rendered granulocytopenic with cyclophosphamide. prior intraperitoneal immunostimulation of mice with complete freund's adjuvant (cfa) or mycobacterium bovis (bacille calmette-guèrin; bcg) increas ... | 1977 | 328788 |
| mechanisms of action of immunopotentiating agents in cancer therapy. | | 1977 | 329658 |
| penetration of cells into millipore diffusion chambers. | | 1977 | 330180 |
| plasmodium yoelii and plasmodium vinckei: the effects of nonspecific immunostimulation on murine malaria. | | 1977 | 330190 |
| in vivo transfer of antitumor activity by peritoneal exudate cells from mice treated with corynebacterium parvum: reduced effect in irradiated recipients. | | 1977 | 330869 |
| management of metastatic breast cancer. | | 1977 | 330978 |
| canine migration inhibitory factor: effect of corynebacterium parvum administration. | peripheral blood lymphocytes from dogs sensitized to streptolysin o (slo) were assayed for migration inhibitory factor (mif) production by the indirect mif test, using guinea pig peritoneal exudate cells as the source of macrophages. a specific direct correlation was established between the degree of inhibition of migration and the concentration of slo-stimulated supernatants from lymphocyte cultures (slo-s) of untreated normal dogs. undiluted slo-s inhibited migration by 66.8%, whereas a diluti ... | 1977 | 332636 |
| corynebacterium parvum as the priming agent in the production of tumor necrosis factor in the mouse. | | 1977 | 333124 |
| [biosynthesis of the nucleotide portion of the vitamin b12 molecule by microorganisms]. | | 1977 | 333243 |
| [porphyrinsynthesis by propionibacterium acnes (author's transl)]. | strains of p.a. were isolated from seborrheic filaments from 11 persons and investigated according to their production of porphyrins. after growing the organisms during a 5 resp. 10 days cultivation period on solid as well as in liquid culture medium the quantity and quality of the bacterial porphyrins were determined. there existed intense variations in quantity not only when the special strains were compared with each other but also when the same strains were treated with different preparation ... | 1977 | 334087 |
| mechanism of corynebacterium parvum anti-tumour activity. ii. protective effect in t-cell-deprived mice. | the natural resistance to syngeneic mammary carcinoma was reduced by thymectomy alone in adult c3h mice or in mice thymectomized, lethally irradiated and restored with bone-marrow cells (tx rb). the protective effect of c. parvum was not modified by adult thymectomy but it was reduced in tx rb mice. the injection of thymic cells to tx rb mice or the elimination of t cell precursors in bone-marrow cells injected in tx rb mice did not increase the protective effect of c. parvum. these results were ... | 1977 | 334678 |
| immunotherapy in the treatment of cancer. | this article is a review of immunotherapy in the treatment of cancer incorporating the history of immunotherapy in the nineteenth and twentieth centuries, assessment of the techniques currently in use and of possible future developments. although immunotherapy is not established as a therapeutic technique, evidence suggests that the immune response does influence the development of neoplastic cells. a better understanding of the immune response and its control may lead to the production of effic ... | 1977 | 337486 |
| the reversal of established enhancement in rat cardiac allografts. | established enhancement in rat cardiac allografts was challenged in a variety of ways in an attempt to provoke rejection. incompatible skin grafts, injections of sensitised lymphocytes, and the administration of the macrophage-stimulating agent corynebacterium parvum proved ineffective. however, levamisole, which stimulates both macrophages and sensitised lymphocytes, caused rejection in four of a group of six as rats bearing enhanced (august x as)f1 hybrid heart allografts. a combination of c. ... | 1977 | 339437 |
| mechanism of nonspecific macrophage-mediated cytotoxicity: evidence for lack of dependence upon oxygen. | peritoneal macrophages elicited in c3h/hj mice by the i.p. injection of corynebacterium parvum were cytotoxic to allogeneic virus-transformed fibroblasts in vitro. cytotoxicity was demonstrated in a morphologic (plaque) assay, and quantitated by measuring macrophage-mediated inhibition of incorporation of 3h-thymidine by the target cells. the cytotoxic effect was well established by 6 hr of macrophage-fibroblast interaction, and was retained in cultures from which the supernatant was removed bef ... | 1978 | 340584 |
| suppression of natural killer cell cytotoxicity by splenocytes from corynebacterium parvum-injected, bone marrow-tolerant, and infant mice. | natural killer (nk) cell cytotoxicity to yac-1 lymphoma was investigated in mice tolerant to bone marrow grafts (bm-tolerant), corynebacterium parvum- (c. parvum) treated mice, and infant mice. also the comparison was made between the nk cell and the hemopoietic-resistance effector (hr-e) cells. it was found that the bm-tolerant mice and c. parvum-treated mice showed either no or markedly decreased nk cell cytotoxicity. these mice were also nonresponders to bone marrow grafts in vivo. the lack o ... | 1978 | 342602 |
| antitumor activity of corynebacterium parvum. | | 1978 | 343523 |
| the cells involved in the modification of the in vitro immune response by corynebacterium parvum (c. parvum). | | 1977 | 344096 |
| immunological adjuvants in cancer immunotherapy. | | 1977 | 344097 |
| host responses in adjuvant contact suppression of experimental rat tumours. | bcg (glaxo) and c. parvum (wellcome cn 6134) have been examined for suppression of growth of a range of syngeneically transplanted rat tumours, both carcinogen-induced and of spontaneous origin. treatment by locally applied adjuvant controlled growth of both immunogenic and non-immunogenic tumours, and the response to highly immunogenic tumours was not abolished by host immunosuppression with whole body irradiation known to abrogate induction of tumour-specific immunity. in addition, rat tumour ... | 1977 | 344098 |
| various modalities of local administration of bacterial immunostimulants in transplantable rat tumours and in primitive methylcholanthrene mouse tumours. | the frequent use of intra-lesional injection of bacterial immunostimulants is hampered by apparent rarity of susceptible tumours, absence of therapeutic effect on large tumours, lack of variety of experimental models, eventual traumatism which is feared in case of intra-lesional, and injection in visceral cancers. (1) methylcholanthrene induced primitive tumours in mice are more frequently susceptible when the carcinogen induction dosage is low (0.01 mg). (2) using transplantable rat tumours, on ... | 1977 | 344100 |
| monitoring of a multi-modal schedule for the treatment of disseminated breast cancer. | 39 women and 1 man have been monitored by sequential cea, immunoglobulin, lymphocyte and monocyte readings, hydroxyproline excretion, scans and x-rays. cea is shown to be a useful monitor of disease. the significance of the lymphocyte counts is discussed. | 1977 | 344101 |
| a phase i study of a multi-modal schedule with corynebacterium parvum. | a phase i study of an immuno-chemotherapy regime was carried out using c. parvum as an immune-modulator. 14 women were studied. all received doses of c. parvum ranging from 2.5 mg to 21 mg administered in 1 litre of dextrose saline over 4 h. no evidence of tumour enhancement was observed. | 1977 | 344102 |
| clinical trial with corynebacterium parvum. | corynebacterium parvum was administered to sixteen patients with malignant tumors submitted to repeated chemotherapy courses. a total of 428 injections of c. parvum at a dose of 3.5 mg/m2 in weekly, biweekly and monthly administration was given between the chemotherapy courses. injection of c. parvum was followed by fever and local pain in 15/16 patients. three patients presented a local ulceration during the initial period of weekly injections. splenomegaly was observed after the second month o ... | 1977 | 344103 |
| clinical experience in the use of c. parvum in the treatment of locally advanced carcinoma of the breast. | twenty-one patients with locally advanced breast cancer which had failed to respond to conventional therapy have been treated by infusion of c. parvum (strain cn 6134, wellcome research laboratories) in 5% dextrose. thirteen patients had a single dose of 15 mg. c. parvum over 4 h and 8 patients received 5 daily infusions of 4 mg c. parvum over 1 h. in 3 patients there was some evidence of tumour regression. pyrexia, often associated with rigors, headaches, vomiting and variations in blood pressu ... | 1977 | 344104 |
| clinical studies with corynebacterium parvum. | in a pilot study twelve patients with malignant disease were treated with corynebacterium parvum. the clinical results were encouraging. a prospective randomised controlled clinical trial of c. parvum therapy in the treatment of patients with carcinoma of the bronchus began in august 1976. 22 pateints have been admitted to the trial and 11 treated with c. parvum. clinical progress is reported. radiological, haematological, biochemical and immunological measurements have been made and these resul ... | 1977 | 344105 |