| activation of rac, cdc42 and other downstream signalling molecules by bartonella bacilliformis during entry into human endothelial cells. | bartonella bacilliformis is an intracellular bacterial pathogen of human endothelial cells. in vitro incubation of b. bacilliformis with human endothelial cells leads to the formation of filamentous actin extensions (filopodia) within 30 min, followed by formation of membrane rufflings or lamellipodia within 1 h of incubation. by immunofluorescence, f-actin phalloidin staining and anti-rac antibodies were shown to co-localize in the membrane rufflings, indicating the recruitment of activated rac ... | 2002 | 12390349 |
| gyra mutations in ciprofloxacin-resistant bartonella bacilliformis strains obtained in vitro. | we isolated and characterized mutants of bartonella bacilliformis that are resistant to the fluoroquinolone antibiotic ciprofloxacin, which targets the a subunit of dna gyrase. mutants had single point mutations in the gyra gene that changed either asp-90 to gly or asp-95 to asn and had 3- or 16-fold higher resistance, respectively, to ciprofloxacin than did wild-type b. bacilliformis. asp-95 is homologous to asp-87 of escherichia coli gyra and is a common residue mutated in fluoroquinolone-resi ... | 2003 | 12499219 |
| differential expression of the invasion-associated locus b (ialb) gene of bartonella bacilliformis in response to environmental cues. | bartonella bacilliformis is the causative agent of the biphasic human disease, oroya fever. during the primary disease phase, up to 100% of the circulating erythrocytes can be parasitized and 80% lysed. during the secondary phase of this disease, bacterial invasion shifts to endothelial cells lining the vasculature. b. bacilliformis is transferred between human hosts by the sandfly, lutzomyia verrucarum. to investigate the regulation of ialb by environmental cues signaling vector-to-host transmi ... | 2003 | 12668141 |
| [systematics of the lutzomyia species of the verrucarum theodor group, 1965 (diptera: psychodiadae)]. | the verrucarum group of phlebotomine sand flies includes vectors of leishmania spp. and bartonella bacilliformis, and from the perspective of public health is considered as one of the most important groups of neotropical phlebotomine sand flies. due to marked morphological similarity among species constituting this group, the identification based on conventional taxonomic characters can be difficult. consequently, the verrucarum group has been the focus of numerous taxonomic comparisons which ha ... | 2003 | 12696402 |
| cloning and characterization of an outer membrane protein (lip18) from helicobacter bizzozeronii. | a recombinant lambda-zap ii phage was selected by screening a genomic library of helicobacter bizzozeronii (hb) using antibodies from a naturally infected cat. dna sequencing resulted an open reading frame containing 172 codons with a predicted molecular mass of 18 kda (lip18). the amino acid sequence showed 22.1, 55.2, 56.7 and 57.1% identity to peptidoglycan-associated lipoprotein of helicobacter pylori, agrobacterium tumefaciens, bartonella bacilliformis, respectively. a peptidoglycan associa ... | 2003 | 12825349 |
| immunofluorescence detection of bartonella bacilliformis flagella in vitro and in vivo in human red blood cells as viewed by laser confocal microscopy. | | 2003 | 12860693 |
| studies on the identification of deforming factor from bartonella bacilliformis. | | 2003 | 12860696 |
| molecular cloning and analysis of a region of the bartonella bacilliformis genome encoding nlpd, l-isoaspartyl methyltransferase and yajc homologs. | the nlpd/lppb homolog of the human pathogen, bartonella bacilliformis, is an immunogenic 43-kda protein that is encoded by a 1206-bp open reading frame (orf-401). the regions flanking the nlpd/lppb gene of b. bacilliformis were sequenced to determine if it is located within the rpos operon, as it is in most bacteria. we report that the b. bacilliformis nlpd/lppb gene is located immediately downstream of pcm, a gene encoding a 25-kda protein, l-isoaspartyl protein carboxyl methyltransferase, that ... | 2003 | 12941162 |
| carrión's disease. i. studies on plants claimed to be reservoirs of bartonella bacilliformis. | | 1953 | 13065631 |
| carrión's disease. ii. presence of bartonella bacilliformis in the peripheral blood of patients with the benign form. | | 1953 | 13065632 |
| [further research on bartonella bacilliformis. iii. experiments with rhesus monkeys and body lice on transmissibility of the disease]. | | 1953 | 13079109 |
| [new studies on bartonelle bacilliformis. 4. electron-optical study of blood smears containing bartonella bacilliformis]. | | 1953 | 13137391 |
| [carrion's disease; trial experimental infection of white mouse with intranasal inoculation of bartonella bacilliformis]. | | 1957 | 13460670 |
| [carrion's disease; morphological study of bartonella bacilliformis by electron microscope]. | | 1957 | 13460671 |
| [carrion's disease; bartonella bacilliformis resistance to lyophilization]. | | 1957 | 13460686 |
| infectious angiogenesis: bartonella bacilliformis infection results in endothelial production of angiopoetin-2 and epidermal production of vascular endothelial growth factor. | pathological angiogenesis, the development of a microvasculature by neoplastic processes, is a critical component of the development of tumors. the role of oncogenes in the induction of angiogenesis has been extensively studied in benign and malignant tumors. however, the role of infection in inducing angiogenesis is not well understood. verruga peruana is a clinical syndrome caused by the bacterium bartonella bacilliformis, and is characterized by the development of hemangioma-like lesions, in ... | 2003 | 14507641 |
| mitogenic effect of bartonella bacilliformis on human vascular endothelial cells and involvement of groel. | bartonellae are bacterial pathogens for a wide variety of mammals. in humans, bartonellosis can result in angioproliferative lesions that are potentially life threatening to the patient, including bacillary angiomatosis, bacillary peliosis, and verruga peruana. the results of this study show that bartonella bacilliformis, the agent of oroya fever and verruga peruana, produces a proteinaceous mitogen for human vascular endothelial cells (huvecs) that acts in a dose-dependent fashion in vitro with ... | 2003 | 14638782 |
| identification and characterization of the ddlb, ftsq and ftsa genes upstream of ftsz in bartonella bacilliformis and bartonella henselae. | homologues of the cell division protein ftsz were previously identified in bartonella bacilliformis and bartonella henselae. we report herein that ftsz is located at the distal end of an operon that includes ddlb, ftsq, and ftsa. these genes code for homologues of d-alanine d-alanine ligase, an enzyme involved in cell wall biosynthesis, and ftsq, and ftsa, which are involved in cell division. the ddlb, ftsq, and ftsa proteins from bartonella species are most homologous to proteins in closely rel ... | 2003 | 14659047 |
| complement fixation and weil-felix reaction in rabbits inoculated with bartonella bacilliformis. | | 1950 | 14794897 |
| [new investigations on bartonella bacilliformis. i. morphology of cultured variety]. | | 1952 | 14951682 |
| [new investigations on bartonella bacilliformis. ii. effects of sulfonamides & antibiotics in vitro]. | | 1952 | 14959269 |
| report of an unusual case of persistent bacteremia by bartonella bacilliformis in a splenectomized patient. | we report a case of a 56-year-old man with a history of splenectomy for idiopathic thrombocytopenic purpura who developed persistent bacteremia in the acute phase of human bartonellosis. this patient did not develop hemolytic anemia. only after several courses of antibiotic treatment was the infection eradicated. this is an unusual case of overwhelming post-splenectomy infection by bartonella bacilliformis, which provides clinical evidence that the spleen is a critical effector organ of clearanc ... | 2004 | 15238689 |
| population genetic analysis of bartonella bacilliformis isolates from areas of peru where carrion's disease is endemic and epidemic. | carrion's disease is caused by infection with the alpha-proteobacterium bartonella bacilliformis. distribution of the disease is considered coincident with the distribution of its known vector, the sand fly lutzomyia verrucarum. recent epidemics of b. bacilliformis infections associated with atypical symptomatology in nonendemic regions have raised questions regarding the historic and present distribution of this bacterium and the scope of disease that infection causes. phylogenetic relationship ... | 2004 | 15297516 |
| evasion of toll-like receptor 5 by flagellated bacteria. | toll-like receptor 5 (tlr5) recognizes an evolutionarily conserved site on bacterial flagellin that is required for flagellar filament assembly and motility. the alpha and epsilon proteobacteria, including the important human pathogens campylobacter jejuni, helicobacter pylori, and bartonella bacilliformis, require flagellar motility to efficiently infect mammalian hosts. in this study, we demonstrate that these bacteria make flagellin molecules that are not recognized by tlr5. we map the site r ... | 2005 | 15956202 |
| characterization and expression analysis of the groesl operon of bartonella bacilliformis. | the groesl operon of bartonella bacilliformis, a facultative intracellular, gram-negative bacterium and etiologic agent of oroya fever, was characterized. sequence analysis revealed an operon containing two genes of 294 (groes) and 1632 nucleotides (groel) separated by a 55-nt intergenic spacer. the operon is preceded by a 72-nt orf (orf1) that encodes a hypothetical protein with homology to a portion of the hrca repressor for groesl. a divergent fumarate hydratase c (fumc) gene lies further ups ... | 2005 | 16126349 |
| production of recombinant protein pap31 and its application for the diagnosis of bartonella bacilliformis infection. | tropical bartonellosis is a highly fatal epidemic and endemic infectious disease that occurs throughout the communities of the andes mountains in south america. the disease is caused by the facultative intracellular bacteria, bartonella bacilliformis. the emergence of bartonellosis in new geographic areas and an increase in the number of reported cases suggest the need for a rapid test for epidemiologic study and investigation of the disease burden. the objective of this research is to develop a ... | 2005 | 16481528 |
| bartonella bacilliformis groel: effect on growth of human vascular endothelial cells in infected cocultures. | bartonella are the only bacteria known to induce angioproliferative lesions of the human vasculature and liver during infection. previous work from our lab suggests that groel participates in the mitogenic response observed in huvec cultures supplemented with the soluble fraction of bartonella bacilliformis. work in this study shows that exposure to high concentrations of the fraction is actually cytotoxic for huvecs. to analyze this phenomenon, live b. bacilliformis-huvec cocultures were employ ... | 2005 | 16481529 |
| the identification of two protective dna vaccines from a panel of five plasmid constructs encoding brucella melitensis 16m genes. | five candidate genes from the brucella melitensis 16m genome were selected. eukaryotic expression plasmids encoding these antigens were constructed and expression was verified in vitro from transfected cos7 cells. each vaccine was assessed for protective efficacy in a balb/c mouse brucellosis infection model. from these experiments two protective dna vaccines were identified: p-omp25 and p-ialb. the omp25 antigen (bmei1249) has previously been studied in terms of brucella virulence, serodiagnosi ... | 2007 | 17049676 |
| [phlebotomine sandflies and transmission of disease agents around the mediterranean basin]. | around 800 species of phlebotomine sandflies are widely distributed in tropical and temperate areas. some sand flies are documented vectors of human disease agents including parasitic protozoa, (leishmania spp), bacteria (bartonella bacilliformis) and viruses (phlebovirus). in addition to presenting morphologic, taxonomic and biologic aspects of phlebotomine sandflies, this report focuses on ecologic, epidemiologic, ethologic, and anthropic factors contributing to the proliferation of sand flies ... | 2006 | 17201284 |
| molecular mechanisms of resistance to antibiotics in bartonella bacilliformis. | bartonella bacilliformis is the aetiological agent of carrion's disease. although ciprofloxacin, rifampicin and erythromycin have been successfully used in the treatment of the disease, failures and relapses have been reported. the objective of our study was to select in vitro mutants resistant to antibiotics in order to determine the frequency of mutations and to characterize the mechanism of resistance at the molecular level. | 2007 | 17449882 |
| discovery of new infectious diseases - bartonella species. | | 2007 | 17554115 |
| bacteremia, fever, and splenomegaly caused by a newly recognized bartonella species. | bartonella species cause serious human infections globally, including bacillary angiomatosis, oroya fever, trench fever, and endocarditis. we describe a patient who had fever and splenomegaly after traveling to peru and also had bacteremia from an organism that resembled bartonella bacilliformis, the causative agent of oroya fever, which is endemic to peru. however, genetic analyses revealed that this fastidious bacterium represented a previously uncultured and unnamed bartonella species, closel ... | 2007 | 17554119 |
| mixed infections, cryptic diversity, and vector-borne pathogens: evidence from polygenis fleas and bartonella species. | coinfections within hosts present opportunities for horizontal gene transfer between strains and competitive interactions between genotypes and thus can be a critical element of the lifestyles of pathogens. bartonella spp. are alphaproteobacteria that parasitize mammalian erythrocytes and endothelial cells. their vectors are thought to be various biting arthropods, such as fleas, ticks, mites, and lice, and they are commonly cited as agents of various emerging diseases. coinfections by different ... | 2007 | 17693558 |
| genomic analysis of bartonella identifies type iv secretion systems as host adaptability factors. | the bacterial genus bartonella comprises 21 pathogens causing characteristic intraerythrocytic infections. bartonella bacilliformis is a severe pathogen representing an ancestral lineage, whereas the other species are benign pathogens that evolved by radial speciation. here, we have used comparative and functional genomics to infer pathogenicity genes specific to the radiating lineage, and we suggest that these genes may have facilitated adaptation to the host environment. we determined the comp ... | 2007 | 18037886 |
| isolation and characterization of bartonella bacilliformis from an expatriate ecuadorian. | carrion's disease is typically biphasic with acute febrile illness characterized by bacteremia and severe hemolytic anemia (oroya fever), followed by benign, chronic cutaneous lesions (verruga peruana). the causative agent, bartonella bacilliformis, is endemic in specific regions of peru and ecuador. we describe atypical infection in an expatriate patient who presented with acute splenomegaly and anemia 3 years after visiting ecuador. initial serology and pcr of the patient's blood and serum wer ... | 2008 | 18094131 |
| heterogeneity of susceptibility to fluoroquinolones in bartonella isolates from australia reveals a natural mutation in gyra. | bartonella sp. are intracellular bacteria associated with an increasing number of clinical manifestations but with few published data on in vitro susceptibility testing of antibiotics. our objective was to evaluate in vitro antibiotic susceptibilities of 20 new bartonella isolates from animals in australia. | 2008 | 18334491 |
| molecular evidence for bartonella spp. in cat and dog fleas from germany and france. | nine hundred and fifty-two fleas were collected from 148 cats and 133 dogs at 18 widely distributed geographic locations in germany and france and examined for the presence of six different bartonella spp. (bartonella bacilliformis, bartonella clarridgeiae, bartonella elizabethae, bartonella henselae, bartonella quintana, bartonella vinsonii subsp. berkhoffii) by pcr. thirty-five specimens (3.7%) tested positive for either b. henselae (14 positive fleas) or b. clarridgeiae (21 positive fleas). d ... | 2008 | 18489542 |
| infection-associated type iv secretion systems of bartonella and their diverse roles in host cell interaction. | type iv secretion systems (t4sss) are transporters of gram-negative bacteria that mediate interbacterial dna transfer, and translocation of virulence factors into eukaryotic host cells. the alpha-proteobacterial genus bartonella comprises arthropod-borne pathogens that colonize endothelial cells and erythrocytes of their mammalian reservoir hosts, thereby causing long-lasting intraerythrocytic infections. the deadly human pathogen bartonella bacilliformis holds an isolated position in the barton ... | 2008 | 18489724 |
| bartonella bacilliformis anemia (oroya fever); a study of 30 cases. | | 1948 | 18875365 |
| balb/c mice resist infection with bartonella bacilliformis. | bartonellosis due to bartonella bacilliformis is a highly lethal endemic and sometimes epidemic infectious disease in south america, and a serious public health concern in perú. there is limited information on the immunologic response to b. bacilliformis infection. the objective of this research was to produce experimental infection of balb/c mice to b. bacilliformis inoculation. | 2008 | 18957122 |
| the pathophysiology of the acute phase of human bartonellosis resembles aids. | human bartonellosis is a south american anthroponosis caused by bartonella bacilliformis. the disease has an acute phase characterized by invasion of red blood cells by parasites, and consequent severe anemia; and a chronic phase presenting with benign vascular tumors. during the acute phase, affected individuals are prone to developing opportunistic infections with a variety of organisms similar to the ones seen in aids. after antibiotic treatment is instituted, a subgroup of patients may devel ... | 2010 | 19665314 |
| genomics of host-restricted pathogens of the genus bartonella. | the alpha-proteobacterial genus bartonella comprises numerous arthropod-borne pathogens that share a common host-restricted life-style, which is characterized by long-lasting intraerythrocytic infections in their specific mammalian reservoirs and transmission by blood-sucking arthropods. infection of an incidental host (e.g. humans by a zoonotic species) may cause disease in the absence of intra-erythrocytic infection. the genome sequences of four bartonella species are known, i.e. those of the ... | 2009 | 19696500 |
| susceptibility of owl monkeys (aotus nancymaae) to experimental infection with bartonella bacilliformis. | bartonellosis, caused by bartonella bacilliformis, is a clinically significant disease in parts of south america, where it is characterized by fever and hemolytic anemia during the often-fatal acute stage and warty skin eruptions during chronic disease. in this study, we evaluated owl monkeys (aotus nancymaae) as a potential model for studying the immunogenicity and pathology of bartonellosis. two groups of animals (n = 3 per group) received either 9.5 x 10(7) cfu b. bacilliformis by the id rout ... | 2008 | 19793460 |
| etiology of oroya fever : i. cultivation of bartonella bacilliformis. | a pure culture of a microorganism resembling in morphology and pathogenic action bartonella bacilliformis has been obtained from blood taken during life from a case of oroya fever which ended fatally. the blood taken at lima into citrate solution and transported to new york at refrigerator temperature yielded positive cultures 28 days after its withdrawal from the patient. the strain of bartonella bacilliformis thus isolated grows well on the semisolid leptospira medium, and also on slant agar c ... | 1926 | 19869166 |
| etiology of oroya fever : ii. viability of bartonella bacilliformis in cultures and in the preserved blood and an excised nodule of macacus rhesus. | 1. animals immunized with the formalinized filtrates of young toxic cultures of b. botulinus produce an antitoxic serum poor in precipitins. 2. animals immunized with the formalinized filtrates of old and partly autolyzed toxic cultures produce an antitoxic serum containing precipitins. 3. animals immunized with toxin-free autolyzed bacteria produce a serum free from antitoxin but rich in specific precipitins. 4. animals immunized with the filtrates of an atoxic variant produce a serum free from ... | 1926 | 19869204 |
| etiology of oroya fever : iii. the behavior of bartonella bacilliformis in macacus rhesus. | the experiments reported here were carried on in the main with passage strains of bartonella bacilliformis, and the results indicate that the virulence of the organism has been considerably enhanced by passage through susceptible animals. while the animals of the earlier experimental series showed no anemia, some of the present group manifested a definite reduction in the number of red cells and in hemoglobin, and in one instance (m. rhesus 25) anemia was of the extreme type so often associated ... | 1926 | 19869217 |
| etiology of oroya fever : iv. the effect of inoculation of anthropoid apes with bartonella bacilliformis. | the inoculation of a chimpanzee with cultures and a passage strain of bartonella bacilliformis induced local reactions which, while definite and characteristic, progressed less rapidly and were much less striking than those in the control rhesus monkey. bartonella bacilliformis was demonstrated in the blood corpuscles with difficulty, and the fever was slight compared with the high and persistent fever of the rhesus monkey. in both the swelling of the lymph glands was an early symptom and consta ... | 1926 | 19869218 |
| etiology of oroya fever : v. the experimental transmission of bartonella bacilliformis by ticks (dermacentor andersoni). | experiments are reported in which bartonella bacilliformis was transmitted from infected to normal rhesus monkeys by the bite of the tick, dermacentor andersoni. a long period of feeding, both on the infected animal and on the normal animal subjected to infection, was required in order to secure positive results. the infection transmitted by the ticks was mild, but definite, as shown by the recovery of bartonella bacilliformis from the lymph nodes and blood. | 1926 | 19869219 |
| the etiology of verruga peruana. | a saline suspension of a subcutaneous nodule excised from a verruga patient, and kept in the refrigerator for 14 days, on inoculation into two young macacus rhesus monkeys (nos. 33 and 34) induced irregular febrile reactions and enlargement of the lymph glands, and in one instance a subcutaneous nodule arose, independently of direct inoculation, on the tail. a microorganism has been isolated from the blood of both animals, and from the experimental nodule, which in pathogenic properties and in c ... | 1927 | 19869238 |
| etiology of oroya fever : vi. pathological changes observed in animals experimentally infected with bartonella bacilliformis. the distribution of the parasites in the tissues. | the pathological changes observed in the organs in macacus rhesus monkeys which have succumbed to severe infection with bartonella bacilliformis are similar to those found in human organs in persons dying of oroya fever. the characteristic changes in the liver are the zonal necrosis of the cells around the hepatic veins, involving active macrophagocytosis of invading polymorphonuclear leucocytes in the necrotic areas, and a marked endothelial hyperplasia in the sinusoids or around the portal vei ... | 1927 | 19869264 |
| etiology of oroya fever : vii. the response of the skin of macacus rhesus and anthropoid apes to inoculation with bartonella bacilliformis. | bartonella bacilliformis failed to induce lesions when merely rubbed on the surface of the intact skin of a chimpanzee, an ourang-utan, and numerous macacus rhesus monkeys, although when applied to the scarified skin of the same animals it gave rise to extensive lesions. application of infectious material to the scarified skin did not always induce verruga lesions, but intradermal inoculation almost invariably gave rise to nodule formation. the localization of bartonella bacilliformis in the ski ... | 1927 | 19869265 |
| etiology of oroya fever : viii. experiments on cross-immunity between oroya fever and verruga peruana. | nine monkeys (macacus rhesus) and a chimpanzee which had recently recovered from an infection with the oroya strain of bartonella bacilliformis were tested for immunity against the verruga strain of bartonella bacilliformis as well as against the homologous strain. complete immunity to both strains was demonstrated. the result establishes the identity of the strains and is in agreement with the result of comparative serological study. the criteria of recovery include not only the subsidence of f ... | 1927 | 19869288 |
| etiology of oroya fever : ix. bacterium peruvianum, n. sp., a secondary invader of the lesions of verruga peruana. | a minute, pleomorphic, motile, gram-negative bacterium has been isolated from two specimens of nodular tissue from human verruga. in films and sections of the original tissues the organism in question is difficult to distinguish from bartonella bacilliformis, with which it was associated, and even in pure culture it has a number of properties in common with that parasite. no sugars are fermented by it, it is an obligate aerobe, the optimum temperature for its growth is 25 degrees c., and it has ... | 1928 | 19869395 |
| etiology of oroya fever : x. comparative studies of different strains of bartonella bacilliformis, with special reference to the relationship between the clinical types of carrion's disease and the virulence of the infecting organism. | through the cooperation of dr. sebastian lorente, director of the national department of public health of peru, nine strains of bartonella bacilliformis have been isolated, by means of the semisolid leptospira medium, from nine of twelve specimens of blood withdrawn from cases of verruga and forwarded from peru under conditions of refrigeration. the cultural titer of the blood specimens immediately after their arrival (2 weeks after withdrawal) varied from 1:10 to 1:100,000. blood from the sever ... | 1928 | 19869408 |
| etiology of oroya fever : xi. comparison of bartonella bacilliformis and bartonella muris. cultivation of bacterium murium, n. sp. | bartonella muris appeared in the blood of all white rats, wild rats, chinese hamster, and mice, from which the spleen was removed, but did not appear in that of splenectomized monkeys, rabbits, or guinea pigs. it has not been possible to transmit b. muris to normal rats, monkeys, rabbits, or guinea pigs, by intraperitoneal, intradermal, or intravenous injection of blood containing b. muris from splenectomized rats. in two instances an acute orchitis was induced in normal rats by injection direct ... | 1928 | 19869409 |
| etiology of oroya fever : xii. influence of malarial infection (plasmodium inui?), splenectomy, or both, upon experimental carrion's disease in monkeys. | the experiments reported were designed to determine the influence of malarial infection (plasmodium inui?), splenectomy, or both combined, upon the course and character of experimental infection with bartonella bacilliformis in monkeys (macacus rhesus and m. cynomolgus). blood withdrawn from a monkey showing spontaneous malarial infection was inoculated intravenously into monkeys (a) 1 month prior to inoculation with virulent verruga material, (b) simultaneously with the verruga material, and (c ... | 1928 | 19869445 |
| etiology of oroya fever : xiii. chemotherapy in experimental bartonella bacilliformis infection. | the therapeutic effect of several antiparasitic chemicals on experimental verruga peruana is described. the drugs were administered by intravenous injection according as the nodules (1) were already developed to an approximate maximum, or (2) were still in the active period of growth. the effect of the drugs was different under the two circumstances of their administration. when they were given after the maturity of the nodules they hastened the regressive process, but when given during active g ... | 1928 | 19869508 |
| etiology of oroya fever : xiv. the insect vectors of carrion's disease. | with a view to determining the mode of infection in carrion's disease, a study of the blood-sucking insects found in the districts of peru where the disease prevails has been carried out, through the cooperation of the rockefeller institute and the rockefeller foundation. the material studied included ticks, mites, midges, lice, fleas, bedbugs, mosquitoes, buffalo gnats, horse-flies, "sheep ticks," 3 species of streblidae, and 3 species of phlebotomus, including phlebotomus verrucarum townsend a ... | 1929 | 19869598 |
| etiology of oroya fever : xv. effect of immune serum on the course of bartonella bacilliformis infection in macacus rhesus. | experiments are reported on the effect upon the course of experimental verruga peruana in macacus rhesus of the injection of (1) small quantities of rabbit immune serum simultaneously with living cultures, (2) one large dose of convalescent monkey serum 24 hours prior to inoculation, (3) a similar preliminary dose followed by three subsequent injections of the serum, (4) three large doses of convalescent serum, following the inoculation. the convalescent serum was found (1) to prevent the multip ... | 1929 | 19869628 |
| etiology of oroya fever : xvi. verruga in the dog and the donkey. | in the experiments here reported, definite verruga lesions, in which the presence of bartonella bacilliformis was established by culture or by passage to rhesus monkeys, were produced in a dog and in a donkey by inoculation of cultures or monkey passage strains. the reaction induced in these animals was entirely local, however; blood cultures were sterile. histologically, the lesions produced were similar to those obtained in monkeys by inoculation of bartonella bacilliformis, except for the pre ... | 1929 | 19869639 |
| the effect of the x-ray on the nodules of verruga peruana. | the supposition that x-ray would affect the developing and the developed verruga nodules experimentally induced in the monkey, has proved correct. the experiments show that the early verruga nodules when exposed to a single, properly graduated dose of x-ray producing merely erythema of the skin, are inhibited in their evolution. moreover, the skin of macacus rhesus monkeys is modified by a single erythema dose of x-ray in such a way that infection of it with bartonella bacilliformis is rendered ... | 1930 | 19869674 |
| demonstration of agglutinins for bartonella bacilliformis. | 1. methods of preparing a satisfactory antigen having been developed, a technique for performing an agglutination test with b. bacilliformis is made available. 2. as a result of repeated intravenous injection of living cultures of b. bacilliformis at short intervals, rabbits have been found to produce a high titre of specific agglutinins which, under the conditions obtaining in the present series of experiments, begins to decline after about one month following the last inoculation. 3. sera from ... | 1942 | 19871168 |
| bartonella bacilliformis, endemic pathogen of the andean region, is intrinsically resistant to quinolones. | to analyze the sequence of the region involved in the development of quinolone resistance of the gyra and parc genes in a series of bartonella bacilliformis isolates recovered prior to the introduction of quinolones, as well as one clinical isolate recovered in the 1970s, establishing the susceptibility levels to nalidixic acid and ciprofloxacin. | 2010 | 19969497 |
| the bartonella and related parasites in man and animals (oroya fever and verruga peruviana): (section of tropical diseases and parasitology). | through the investigations of noguchi on the one hand, and mayer and kikuth on the other, the unity of the aetiology of oroya fever and verruga peruviana has been demonstrated experimentally. the bartonella bacilliformis, the causal organism of oroya fever, belongs to a group of micro-organisms, the parasitic nature of which has been definitely proved during the last few years. tests with a view to transmitting the disease to monkeys, and the aetiology, clinical data, pathology, therapy and immu ... | 1934 | 19989875 |
| feline hemotropic mycoplasmas. | to describe the current understanding of the etiology, pathogenesis, diagnosis, and treatment of feline hemotropic mycoplasmosis (feline infectious anemia). | 2010 | 20230435 |
| [bartonella spp. as a zoonotic pathogens transmitting by blood-feeding arthropods]. | prior to 1993, bartonella bacilliformis was the only member of the bartonella genus. now, the genus bartonella currently contains over 30 species of gram-negative bacteria that parasitize mammalian erythrocytes and endothelial cells. bartonella spp. have been isolated from a variety of mammal species, most often from rodents, ruminants and carnivores, and these animals are implicated as reservoirs for the genus bartonella. the persistent bacteriemia is more readily documented in the primary rese ... | 2010 | 20450002 |
| who is this man? | | 2010 | 20507765 |
| the trw type iv secretion system of bartonella mediates host-specific adhesion to erythrocytes. | bacterial pathogens typically infect only a limited range of hosts; however, the genetic mechanisms governing host-specificity are poorly understood. the alpha-proteobacterial genus bartonella comprises 21 species that cause host-specific intraerythrocytic bacteremia as hallmark of infection in their respective mammalian reservoirs, including the human-specific pathogens bartonella quintana and bartonella bacilliformis that cause trench fever and oroya fever, respectively. here, we have identifi ... | 2010 | 20548954 |
| skin diseases associated with bartonella infection: facts and controversies. | the genus bartonella is composed of a series of species and subspecies. ten of them are responsible for human infections. the best-identified diseases are cat scratch disease (b henselae and possibly b clarridgeiae), trench fever (b quintana), bacillary angiomatosis (b quintana and b henselae), and the spectrum of verruga peruana, carrion disease, and oroya fever (b bacilliformis). controversies exist about the implication of a few other microorganisms being involved in these diseases. several o ... | 2010 | 20797506 |
| multi-locus sequence analysis reveals profound genetic diversity among isolates of the human pathogen bartonella bacilliformis. | bartonella bacilliformis is the aetiological agent of human bartonellosis, a potentially life threatening infection of significant public health concern in the andean region of south america. human bartonellosis has long been recognised in the region but a recent upsurge in the number of cases of the disease and an apparent expansion of its geographical distribution have re-emphasized its contemporary medical importance. here, we describe the development of a multi-locus sequence typing (mlst) s ... | 2011 | 21811647 |
| cytokines and t-lymphocute count in patients in the acute and chronic phases of bartonella bacilliformis infection in an endemic area in peru: a pilot study. | human bartonellosis has an acute phase characterized by fever and hemolytic anemia, and a chronic phase with bacillary angiomatosis-like lesions. this cross-sectional pilot study evaluated the immunology patterns using pre- and post-treatment samples in patients with human bartonellosis. patients between five and 60 years of age, from endemic areas in peru, in the acute or chronic phases were included. in patients in the acute phase of bartonellosis a state of immune peripheral tolerance should ... | 2011 | 21755237 |
| persistence of bartonella spp. stealth pathogens: from sub-clinical infections to vasoproliferative tumour formation. | bartonella spp. are facultative intracellular bacteria that typically cause a long-lasting intraerythrocytic bacteremia in their mammalian reservoir hosts, thereby favoring transmission by blood-sucking arthropods. in most cases, natural reservoir host infections are subclinical and the relapsing intraerythrocytic bacteremia may last weeks, months or even years. in this review, we will follow the infection cycle of bartonella spp. in a reservoir host, which typically starts with an intradermal i ... | 2012 | 22229763 |
| letter: si chaos. | | 2001 | 55546 |
| selective vestibular neurectomy through the posterior fossa in ménière's disease. | the authors report on a series of 18 patients operated through the posterior fossa approach for selective vestibular neurectomy. the indication for surgery consisted of intractable vertigo in cases of ménière's disease. results were excellent with a 94% cure of vertigo and 100% improvement. postoperative hearing results were good with 78% of patients maintaining their discrimination score and 94% their pure tone average threshold. the results and the advantages of this approach are discussed and ... | 2007 | 3225882 |
| craniofacial manifestations of ehlers-danlos syndromes, cutis laxa syndromes, and cutis laxa-like syndromes. | | 2009 | 2697382 |
| [primary transport of acute patients. optimal use of rescue resources exemplified by the canton of graubünden]. | | 2011 | 3927607 |
| [mycology technics]. | | 2013 | 3847144 |
| validation of computer software in process control applications. | | 2013 | 3754576 |
| [open study of clopirac in the treatment of non articular rheumatism (author's transl)]. | | 2005 | 1084347 |
| doing something about domestic violence. | | 2006 | 1636255 |
| a comparative study for fiberoptic and video endoscopic determination of the extent in minimal changes of gastric mucosa using indigo dye spraying. | the image resolution of fiberoptic and video endoscopy was compared in a series of patients with early gastric cancer. eighteen patients were divided into two groups. one group of patients (n = 9) was evaluated with fiberoptic endoscopy while the second group (n = 9) was evaluated using video endoscopy. the extent of cancer invasion, with special attention to size, shape and type of the lesions, was evaluated in each patient. attempts were also made to identify the proximal and distal limits of ... | 2007 | 2374986 |
| bites and stings. part 2. bees and vespids. | | 2008 | 2519523 |
| sce induction by ccnu and pregnancy. | | 2009 | 2704378 |
| antigen-specific helper t cells are essential for cytotoxic t cell responses to metabolically inactivated stimulator cells. | | 1999 | 91517 |
| [the use of audiovisual teaching and learning aids in dentistry]. | in order to intensify university teaching (mastering of the ever increasing advance of knowledge and realization of the specified curriculum with its increased requirements in the teaching and learning process), it will be necessary to use audio-visual teaching aids to a greater extent. the audio-visual tools are used in combination, with due regard to the specificity of each of them. the specificity and the use of diapositives, synchronized slide audiotype series, fragmental films, survey films ... | 2001 | 92833 |
| [cavernosography in erectile dysfunction]. | | 2012 | 3353972 |
| x-associated immunocompetence. | | 1999 | 84980 |
| general-practice training, exeter style. | | 2000 | 87562 |
| the non-removable "bite plate". | | 2000 | 101560 |
| [role of electron microscopy in peripheral nerve pathology (author's transl)]. | | 2000 | 87154 |
| comparison of metal complexes between depyruvamide bleomycin and bleomycin: an important effect of axial donor on metal coordination and oxygen activation. | | 2000 | 88941 |
| differential diagnosis of pelvic masses by gray scale sonography. | an approach to the sonographic differential diagnosis of pelvic masses based on their size, location, internal consistency, and definition of borders is presented. diagnostic schemes were derived from correlating the sonographic features with histomorphology in 170 surgically proven pelvic masses. besides separating pelvic masses into the conventional categories of cystic, complex, and solid, gray scale sonographic features of a pelvic mass can be used to subcategorize these masses into a more u ... | 2000 | 98992 |
| control of thyroglobulin synthesis and secretion (second of two parts). | | 2001 | 88013 |
| the study of enzyme mechanisms by a combination of cosolvent, low-temperature and high-pressure techniques. | | 2001 | 95127 |
| performance of home blood-glucose meters. | | 2001 | 87914 |
| adult respiratory-distress syndrome in salicylate intoxication. | | 2001 | 87755 |
| comments on references to the american board of psychiatry and neurology in an article. | | 2002 | 3369584 |
| autosomal recessive inheritance of nager acrofacial dysostosis. | nager acrofacial dysostosis is a variant of mandibulofacial dysostosis with severe micrognathia, malar hypoplasia, and radial limb defects. most cases are sporadic, but autosomal recessive inheritance has been suggested. a family is reported in which two sibs are affected by this syndrome, presenting further evidence for autosomal recessive inheritance. the recognition of this syndrome as a distinct entity has important implications. after the birth of a child with orofacial malformations sugges ... | 2005 | 3367347 |
| [lymphocyte populations in hbag-positive acute hepatitis]. | | 2005 | 1087387 |
| continuous urodynamic surveillance of babies with myelodysplasia: implications for further neurosurgery. | | 2006 | 1489744 |