| [prognostic significance of cytochemical and functional activity of blood lymphocytes in patients with peptic ulcer and the presence of helicobacter pylori]. | | 1992 | 1434395 |
| colloidal bismuth subcitrate and omeprazole inhibit alcohol dehydrogenase mediated acetaldehyde production by helicobacter pylori. | we have recently shown that helicobacter pylori possesses marked alcohol dehydrogenase (adh) activity and is capable--when incubated with an ethanol containing solution in vitro--of producing large amounts of acetaldehyde. in the present study we report that some drugs commonly used for the eradication of h. pylori and for the treatment of gastroduodenal diseases are potent adh inhibitors and, consequently, effectively prevent bacterial oxidation of ethanol to acetaldehyde. colloidal bismuth sub ... | 1992 | 1435071 |
| cloning and genetic characterization of a helicobacter pylori flagellin gene. | helicobacter pylori produces polar sheathed flagella, which are believed to be essential for the bacterial colonization of the human gastric mucosa. here we report on the cloning and genetic characterization of a h. pylori gene encoding the subunit of the flagellar filament, the flagellin. screening of a genomic library of h. pylori with an oligonucleotide probe derived from the n-terminal amino acid sequence of purified flagellin resulted in a recombinant plasmid clone carrying the flagellin-en ... | 1992 | 1435261 |
| [effect of colloid bismuth treatment on campylobacter pylori infection of the gastric mucosa and the clinical course of non-ulcer dyspepsia]. | there are suggestions, that the idiopathic non-ulcer dyspepsia is related to the chronic gastritis type b coexisting with c. pylori infection. presented studies were aimed at the assessing of an effect of the treatment with de-nol on the course of the idiopathic non-ulcer dyspepsia of c. pylori infection. gastroscopic examination was performed in 52 patients with non-ulcer dyspepsia before and after the treatment with de-nol administered for 4-8 weeks. campylobacter pylori was isolated from 71% ... | 1992 | 1437790 |
| [inflammatory changes in the gastric mucosa of patients with idiopathic non-ulcer dyspepsia and the effect of colloid bismuth treatment on the course of inflammation]. | the studies were aimed at the assessment of the coexistence of non-ulcer dyspepsia with chronic gastritis and campylobacter pylori infection, and of the effect of therapy with de-nol on the course of such disease. the studies involved 50 patients with non-ulcer dyspepsia. prior to and after the treatment with de-nol samples of the mucosa collected from the antrum and corpus of the stomach have been examined histologically with urease test indicating c. pylori infection. chronic gastritis of the ... | 1992 | 1437791 |
| eradication of helicobacter pylori: therapies and clinical implications. | this review presents a critical evaluation of the role of helicobacter pylori eradication in the management of peptic ulcer disease and non-ulcer dyspepsia. on current evidence, h. pylori eradication therapy seems likely to emerge as the most rational and cost-effective treatment for duodenal ulcer. the role of h. pylori eradication in the treatment of gastric ulcer and non-ulcer dyspepsia is unclear and requires further study. the emerging problem of antibiotic resistance in h. pylori is of maj ... | 1992 | 1437952 |
| [prevalence of helicobacter pylori in patients with gastric cancer in panama]. | cancer of the stomach is the second in incidence in panama after the cancer of the prostata. it is studied now the incidence of infection due to helicobacter pylori in patients with gastric carcinoma. it seems to be a significative relationship between the prevalence of gastric carcinoma and h. pylori infections. this observation is important because by the similar therapeutic implications in virus dna hepatitis type b and hepatoma. | 1992 | 1439007 |
| effect of helicobacter pylori on parietal cell sensitivity to pentagastrin in duodenal ulcer subjects. | we have investigated the possibility that hypergastrinaemia in chronic helicobacter pylori infection is a compensatory response to reduced parietal cell sensitivity to gastrin. the acid response to 45-min infusions of pentagastrin at sequential doses (micrograms/kg/h) of 0, 0.031, 0.062, 0.124, and 0.6 was compared before and 1 month after eradication of h. pylori in eight duodenal ulcer patients. the median acid outputs (mmol/h) with the respective infusions were 5.0, 7.5, 26.5, 30.8, and 37.0 ... | 1992 | 1439539 |
| [the rational use of de-nol in the treatment of peptic ulcer and chronic active gastroduodenitis associated with helicobacter pylori]. | | 1992 | 1440381 |
| helicobacter pylori and non-ulcer dyspepsia. | | 1992 | 1440895 |
| [therapy of stomach ulcer--a comparison between the low dosage antacid hydrotalcite and ranitidine--results of a randomized multicenter double-blind study. talcivent study group]. | in a 8 week double-blind randomized multicenter trial in 159 patients with benign gastric ulcer the efficacy of hydrotalcite vs. ranitidine in expediting ulcer healing and in achieving pain relief was determined. 79 patients received hydrotalcite 1000 mg q.i.d. as tablets equalling a total neutralizing capacity of 111.2 mval and 80 patients received ranitidine (300 mg at night). endoscopically controlled healing rates after 4 weeks of therapy amounted to 41.8% with hydrotalcite and 53.8% with ra ... | 1992 | 1441674 |
| active autoimmune gastritis without total atrophy of the glands. | to date, autoimmune gastritis has been diagnosed for the most part only when total atrophy of the oxyntic glands is detected. on the basis of 40 patients without total atrophy of the glands, and with parietal cell antibodies in the serum, we show that the diagnosis of type a gastritis is also possible in the pre-atrophic stage. the histological criteria for the diagnosis of active autoimmune gastritis without total atrophy of the glands are 1. usually dense, diffuse locally emphasized lymphocyti ... | 1992 | 1441676 |
| helicobacter pylori, gastritis, and ulcers in pediatrics. | hp now appears to be more than a simple commensal organism in patients with gastritis or peptic ulcer disease. microbiologic, serologic, and epidemiologic studies all confirm that hp has an important role in children with abdominal pain. hp is found in the gastric mucosa of children with histologically proven gastritis or peptic ulcer. the organism can be transmitted from human to human with evidence of colonization, appearance of gastritis, and serum antibody response. antimicrobial therapy dir ... | 1992 | 1442315 |
| role of helicobacter pylori in gastritis and duodenitis in man. | although helicobacter pylori is now accepted as the major aetiological factor in chronic gastritis in man, many of the factors which determine its pathogenicity are unknown. the organism has adapted to survive in the low-ph environment of the stomach, partly through its ability to buffer hydrogen ion by the hydrolysis of urea and by the presence of lectins on its surface, which bind to gastric mucosa and epithelial cells. after attachment, harmful toxins and enzymes have access to the gastric ce ... | 1992 | 1442334 |
| high prevalence and persistence of cytotoxin-positive helicobacter pylori strains in a population with high prevalence of atrophic gastritis. | helicobacter pylori is strongly associated with both chronic gastritis and duodenal ulcer. certain strains of h. pylori produce a vacuolating cytotoxin in vitro. at new orleans charity hospital, concentrated culture supernatants from 119 of 144 (83%) h. pylori strains isolated from 86 patients at high risk of developing gastric cancer, caused vacuolization in hela s3 cells. cytotoxin activity was neutralized by acid (ph 4) and basic (ph 10) solutions and proteases, and was precipitable by (nh4)2 ... | 1992 | 1442673 |
| prevalence and significance of helicobacter pylori in patients with barrett's esophagus. | a retrospective study for assessment of the prevalence of helicobacter pylori was performed in 107 consecutive patients with columnar-lined epithelium in the esophagus. the presence of hiatal hernia and esophagitis was noted. from 71 patients, biopsy specimens were available for analysis. no difference in the presence or absence of h. pylori was noted, regardless of whether or not there was esophagitis or hiatal hernia. most h. pylori-positive patients show a low bacterial load in the metaplasti ... | 1992 | 1442681 |
| helicobacter pylori-associated ammonia production enhances neutrophil-dependent gastric mucosal cell injury. | the role of neutrophil and its chlorinated oxidant were investigated in helicobacter pylori-induced gastric mucosal injury in vitro. luminol-dependent chemiluminescence (chl) was used to detect neutrophil-derived oxidants. chl activity was significantly elevated when neutrophils were incubated in h. pylori, indicating that h. pylori actually elicits oxidative burst of neutrophils. to assess whether h. pylori-activated neutrophils exert the cytotoxicity for gastric mucosal cells, rabbit gastric m ... | 1992 | 1443147 |
| a mucosal barrier of gastric surfactant identified in the human stomach. | using a special fixation procedure avoiding glutaraldehyde, an oligolamellar lining has been demonstrated by electronmicroscopy on the luminal surface of the human stomach and, with more lamellations, on the epithelial surfaces of oxyntic ducts and parietal cells. these results indicate that, in the human stomach, there is indeed a gastric mucosal barrier consisting of a multi-laminated structure of surface-active phospholipid (sapl). this gastric surfactant is probably produced in parietal cell ... | 1992 | 1445032 |
| haemagglutination patterns of helicobacter pylori. frequency of sialic acid-specific and non-sialic acid-specific haemagglutinins. | thirty-two helicobacter pylori strains were screened for haemagglutination (ha) activity with erythrocytes of 11 different animal species. twenty-three strains (72%) that agglutinated human erythrocytes exhibited a broad-spectrum ha profile. human, guinea pig and bovine erythrocytes high in sialoglycoconjugates were strongly agglutinated by most strains. except for two, seven strains (22%) that did not agglutinate human erythrocytes exhibited a narrow-spectrum ha profile, commonly not inhibitabl ... | 1992 | 1445697 |
| changing pattern of gastric cancer in oxfordshire. | this study compares the incidence rates of histologically confirmed gastric carcinoma in oxfordshire in two five year periods (1960-64, 1984-88). data were available for 215 patients in the first period, and 200 in the second. the overall incidence fell from 18/100,000 to 15/100,000 but when analysed for site, the incidence of antral tumours fell from 10 to 4.5/100,000. in contrast, there was an increase from 2.8 to 5.2/100,000 of tumours of the cardia. these changes were more pronounced in men. ... | 1992 | 1446851 |
| evidence of clonal variants of helicobacter pylori in three generations of a duodenal ulcer disease family. | nine members of a family with a high incidence of duodenal ulcer disease were studied by interview, examination of hospital records, endoscopy, and antral biopsy. helicobacter pylori was confirmed by clo test, histology and culture. dna extraction from pure isolates of h pylori was possible in six family members and strain typing was performed by restriction fragment length polymorphism. dna restriction digestion was followed by vacublotting and then dna hybridisation, using a cdna probe complim ... | 1992 | 1446853 |
| eighteen month follow up of helicobacter pylori positive children treated with amoxycillin and tinidazole. | sixty three children with dyspepsia (mean age 12 years, range one to 18, m/f 41/22) were helicobacter pylori positive by histology of gastric antral biopsy specimens and were treated with a six week course of amoxycillin (50 mg/kg) and tinidazole (20 mg/kg). the endoscopic diagnoses were: normal (16), nodular gastritis (19), oesophagitis (four), duodenal ulcer (13), and gastric ulcer (11). h pylori was eradicated in 54 (87%) and histological gastritis resolved in 51 and was improved in the other ... | 1992 | 1446854 |
| [immunity and the prostaglandin level in gastritis b]. | the indices of systemic and local immunity, level of prostaglandins, presence of helicobacter pylori in the gastric mucosa was studied in 53 patients with gastritis b. patients with superficial antral gastritis showed independent of the presence of helicobacter pylori in the gastric mucosa changes of the systemic immunity and level of pge2 and pgf1 that were abnormal. in atrophy of the antral gastric mucosa and presence there of h. pylori one observed a reduction of the number of t-lymphocytes a ... | 1992 | 1448980 |
| [the efficacy of antibacterial treatment in chronic gastritis of helicobacter etiology]. | a study of 140 patients with chronic gastritis revealed helicobacter pylori in the gastric antral mucosa in 100% and in the duodenum in 50%. there is a direct correlation between the presence and amount of helicobacter pylori in the mucosa, lymphoplasmocytic infiltration, dystrophic changes of epithelium. ampiox treatment proved beneficial both clinically and morphologically. after treatment helicobacter pylori was absent in 65.7%, in the remaining cases it reduced by 5-10 times. | 1992 | 1448981 |
| meta-analysis of the efficacy of antibiotic therapy in eradicating helicobacter pylori. | despite numerous helicobacter pylori treatment studies, the optimum regimen(s) for its eradication remain unclear. our objective was to determine systematically which regimen(s) gave the best pooled eradication rates, by using meta-analysis methodology. a total of 27 studies were identified. pooled eradication rates for single (18.6%), double (48.2%), and triple therapy (82.3%) were statistically highly different (p < 0.0005). eradication rates with amoxicillin (23.0%) and bismuth compounds (19. ... | 1992 | 1449132 |
| helicobacter pylori infection in dental workers: a seroepidemiology study. | the finding of helicobacter pylori in dental plaque suggested that dental workers may be at increased risk of acquiring h. pylori infection from occupational exposure. a cross-sectional survey of 239 dental workers from 37 texas cities (including 89 dentists, 44 dental hygienists, 98 dental assistants, and eight dental students) was conducted. h. pylori infection was determined by the presence of igg antibodies to h. pylori, using a specific and sensitive elisa. participants ranged in age from 1 ... | 1992 | 1449133 |
| gastric and duodenal mucosal prostaglandin concentrations in gastric or duodenal ulcer disease: relationships with demographics, environmental, and histological factors, including helicobacter pylori. | we measured gastric and duodenal mucosal prostaglandin concentrations in 69 patients with active or inactive duodenal or gastric ulcer disease and 26 non-ulcer controls. each underwent endoscopy enabling us to obtain multiple biopsies from the gastric body and antrum and from the duodenal bulb and postbulbar duodenum for measurement of mucosal prostaglandin concentrations, as well as a single biopsy from each region for mucosal histology. using a multivariate linear regression model, we found th ... | 1992 | 1449136 |
| advantage of use of dpm for 14c-urea breath test for the detection of helicobacter pylori. | | 1992 | 1449167 |
| [mucous membrane of the gastric antrum in late periods after selective proximal vagotomy with surgical drainage of the stomach and duodenum]. | a clinicomorphological analysis was performed of the gastric antrum mucous membrane of 60 patients after selective proximal vagotomy because of stenosing duodenal ulcer. the patients were subdivided into two randomized groups depending on the type of the draining operation. the first group had a gastroduodenoanastomosis for the gastric drainage and the second group underwent duodenum plasty (drainage of the duodenum). discontinuation of the pylorus function in the gastric drainage operation resu ... | 1992 | 1449389 |
| activation of human phagocyte oxidative metabolism by helicobacter pylori. | a characteristic feature of chronic antral gastritis is the abundant inflammatory response in close association with helicobacter pylori, but the immunopathological mechanisms of tissue damage are unknown. because reactive oxygen radicals have been implicated in the tissue damage of other chronic inflammatory disorders, we investigated the potential ability of h. pylori sonicate to influence the oxidative burst responsiveness of human polymorphonuclear leukocytes and monocytes. for both cell typ ... | 1992 | 1451968 |
| dyspepsia, helicobacter pylori, and peptic ulcer in a randomly selected population in india. | there seems to be a worldwide geographic variation in the prevalence of peptic ulcer disease, although there are few reliable population based studies. this study aimed to determine the prevalence of peptic ulcer disease in a community in southern india and to evaluate the relationship between dyspeptic symptoms, helicobacter pylori infection, gastritis, and peptic ulcer disease. a sample population was selected randomly from a rural monastic settlement in southern india. subjects were interview ... | 1992 | 1452068 |
| mucosal reactive oxygen metabolite production in duodenal ulcer disease. | to investigate the hypothesis that reactive oxygen metabolites are important in the pathophysiology of duodenal ulcer disease, their production by duodenal mucosal biopsy specimens was measured using luminol and lucigenin amplified chemiluminescence. luminol chemiluminescence, expressed as background corrected median photon emission/mg/min x 10(3) (95% confidence intervals), was increased in duodenal inflammation as assessed macroscopically: ulcers 20.3 (4.8 to 51.3), n = 29; severe duodenitis 1 ... | 1992 | 1452069 |
| helicobacter pylori infection rates in relation to age and social class in a population of welsh men. | | 1992 | 1452089 |
| [a study on the pathogenicity of helicobacter pylori in chronic gastritis and peptic ulcer disease]. | gastroendoscopic biopsy specimens from 366 patients were stained with he, warthin-starrys or giemsa and mucin histochemical methods. positive rate of helicobacter pylori (hp) was 73.8% in chronic gastritis. positive rates of hp in gastric ulcer disease were 88.2%, 91.9%, and 11.1% at the near and distant mucosa of ulcer and in duodenitis, respectively. positive rates of hp in duodenal ulcer disease were 81.5%, 24.6% and 7.2% at the pyloric-antral area and at the near and distant mucosa of duoden ... | 1992 | 1452159 |
| purification and characterization of the urease enzymes of helicobacter species from humans and animals. | the urease enzymes of helicobacter pylori, h. mustelae, h. felis, and h. nemestrinae have been purified to homogeneity by affinity chromatography and characterized. the native urease enzymes of the four organisms were found to be almost identical, with a pi of 6.1 and molecular masses of 480 to 500 kda, as determined by electrophoretic mobility in nondenaturing polyacrylamide gels. transmission electron microscopy of the native urease showed it to be a molecule approximately 13 nm in diameter, w ... | 1992 | 1452359 |
| comparison of commercial serological tests for detection of helicobacter pylori antibodies. | serological testing for helicobacter pylori infection is one of the diagnostic methods of choice. various commercial kits that use different antigens have been developed, but data on their diagnostic accuracy and direct comparisons between the tests are lacking. we aimed to evaluate the sensitivity, specificity, and predictive value of three immunoglobulin g enzyme-linked immunosorbent assay kits: pylori stat, helico-g, and premier h. pylori. serum samples and gastric biopsy findings from 76 pat ... | 1992 | 1452698 |
| evaluation of a commercially available complement fixation test for diagnosis of helicobacter pylori infection and for follow-up after antimicrobial therapy. | commercially available complement fixation test reagents (institute virion ltd., rüschlikon, zurich, switzerland) available in package format were evaluated for the serodiagnosis of helicobacter pylori infection. the assay was compared with bacterial culture and histological giemsa stain of gastric biopsy specimens obtained from 930 patients of different ages and from different ethnic groups, with a variety of upper gastrointestinal tract symptoms. the prevalence, sensitivity, specificity, and p ... | 1992 | 1452707 |
| gastric giardiasis. | to assess the prevalence of gastric giardiasis in patients undergoing upper gastrointestinal endoscopy, and to define the clinicopathological correlates of gastric giardia lamblia infection. | 1992 | 1452790 |
| clinical implications of serum pepsinogen and progastricsin in man. | the serum pepsinogens in man have been reviewed with respect to clinical and physiological significance. the many places of synthesis of pepsinogen (pg a) and progastricsin (pg c) are described. the major part of serum pepsinogen and progastricsin is synthezized in the stomach, and the findings after antrectomy indicate that the majority of the pepsinogens in serum originates from the corpus of the stomach. the concentrations of pepsinogen and progastricsin in serum in relation to stomach diseas ... | 1992 | 1455183 |
| gastric changes in coronary-operated patients with low-dose aspirin. | low-dose aspirin is widely used in patients operated on for coronary disease as secondary prevention of coronary artery occlusion. the changes caused by aspirin in therapeutic doses to gastric mucosa are well documented, but the effect of long-term low-dose aspirin is not so well known. forty-six volunteer coronary-operated patients with daily low-dose aspirin were interviewed postoperatively, and an upper gastrointestinal tract endoscopy was performed and biopsy specimens taken 3 months after t ... | 1992 | 1455187 |
| observer homogeneity in the histologic diagnosis of helicobacter pylori. latent class analysis, kappa coefficient, and repeat frequency. | four pathologists independently examined 82 antral mucosal biopsy specimens for the presence of helicobacter pylori and indicated whether their assessments were certain. the pathologists made a positive diagnosis in from 56% to 84% of the specimens (significant heterogeneity, p < 0.01). the frequency of uncertain diagnoses was from 4% to 20% (p < 0.01). uncertain statements occurred more frequently among negative than among positive diagnoses. for the six pairs of observers the kappa coefficient ... | 1992 | 1455190 |
| triple therapy of helicobacter pylori infection in peptic ulcer. a 12-month follow-up study of 93 patients. | this study was undertaken to evaluate the success of triple therapy in peptic ulcer patients and ulcer relapses. one hundred and one consecutive helicobacter pylori-positive peptic ulcer patients were assigned to an open trial with 2 weeks of treatment with colloidal bismuth subcitrate, amoxicillin, and metronidazole. at the 6-week follow-up only 1 duodenal ulcer was unhealed of 57 active ulcers, and h. pylori was found to be eradicated in 84% of the 100 subjects. the sensitivity to metronidazol ... | 1992 | 1455197 |
| biometric evaluation of gastric urease activity in man. | the 14c-urea breath test is claimed to be the best test for detection of helicobacter pylori infection. we present a procedure for estimating its cutoff value on the basis of biometric evaluation only, without involving other diagnostic methods. cumulative gastric urease activity (ca) was determined during the first 30 min after oral administration of 14c-urea (92.5 kbq) in 56 random volunteers and 49 consecutive patients with peptic ulcer disease. the distribution of ca in random volunteers was ... | 1992 | 1455198 |
| human gastric carcinogenesis: a multistep and multifactorial process--first american cancer society award lecture on cancer epidemiology and prevention. | evidence from pathology and epidemiology studies has been provided for a human model of gastric carcinogenesis with the following sequential stages: chronic gastritis; atrophy; intestinal metaplasia; and dysplasia. the initial stages of gastritis and atrophy have been linked to excessive salt intake and infection with helicobacter pylori. the intermediate stages have been associated with the ingestion of ascorbic acid and nitrate, determinants of intragastric nitrosation. the final stages have b ... | 1992 | 1458460 |
| ph-dependent secretion of gastrin in duodenal ulcer disease: effect of suppressing helicobacter pylori. | patients with duodenal ulcers and helicobacter pylori infection have elevated plasma gastrin concentrations which fall after suppression of the organism. this may be due to h. pylori elevating the ph of the antral mucous layer, therefore preventing luminal acid from inhibiting gastrin release. to test this idea, we measured the plasma gastrin concentrations under basal conditions and in response to 4% peptone when the gastric lumen was maintained at ph 2.5 and at ph 5.5 by gastric perfusion. we ... | 1992 | 1459351 |
| character and origin of vacuoles induced in mammalian cells by the cytotoxin of helicobacter pylori. | cytotoxic activity of culture supernates of helicobacter pylori is manifested by vacuolation of mammalian cells in vitro. the formation and maturation of toxin-induced vacuoles in hela cells has been studied to examine the possibility that they are autophagosomal in nature. observation by light microscopy revealed that vacuoles originate in a perinuclear position, increasing in number and size until cell degeneration and lysis occur after 48 h. ultrastructural study of mature vacuoles indicated ... | 1992 | 1460658 |
| [how is stomach ulcer transmitted? epidemiology of helicobacter pylori]. | | 1992 | 1461054 |
| [treatment of stomach ulcer with bismuth subnitrate, oxytetracycline and metronidazole]. | 60 patients with recurrent duodenal ulcers were treated with bismuth subnitrate, oxytetracycline and metronidazole. helicobacter pylori status was assessed before and after treatment by means of the 14c-urea breath test. all patients were helicobacter positive before treatment. four weeks after cessation of therapy h pylori had been eradicated in 57 out of 60 patients (95%). the ulcer healing rate was 100% after six weeks. 43% of the patients complained of moderate to severe side effects, mainly ... | 1992 | 1462293 |
| helicobacter pylori-related gastritis and gastric ulcer. a continuum of progressive epithelial degeneration. | one hundred forty-five consecutive gastric biopsy specimens showing colonization by helicobacter pylori (hp) were studied. biopsy specimens were obtained from patients with the following conditions: gastric ulcer (gu; 76), active chronic gastritis (acg; 52), gu with duodenal ulcer (du; 10), and acg with du (7). the mean age of the patients in the acg group was 8.6 years less than the patients in the gu group. helicobacter pylori colonization and hp-induced epithelial degeneration (ed) were quant ... | 1992 | 1462954 |
| the diagnosis of helicobacter pylori infection in uremic patients. | two urease-based tests--the urease slide test and the radiolabeled urea breath test, are commonly used for the diagnosis of helicobacter pylori infection of the stomach. the reliability of these tests in chronic uremia was compared with serological tests for h pylori antibodies, and with direct detection of the organism by microscopy or culture of gastric antral biopsies. twenty-seven patients with chronic renal failure and dyspepsia underwent upper gastrointestinal endoscopy. twelve of these pa ... | 1992 | 1462985 |
| workshop on gastroduodenal pathology and helicobacter pylori, 28-30 november 1991. | | 1992 | 1463994 |
| [serologic detection of antibodies to helicobacter pylori in children and adolescents using elisa]. | serum antibodies anti-helicobacter pylori (h.p.) which are specific against antigenic determinants of the bacterial body, were determined in 183 non-ulcer dyspeptic children and adolescents, aged 7- to 20 years. 108 patients (59%) of the same group underwent fibroendoscopy for direct detection of h.p. in bioptic specimens of the stomach and duodenum microbiological methods. discrimination analysis revealed a overall positive correlation between the results of the two methods: p < 0.01. for detec ... | 1992 | 1464085 |
| [helicobacter pylori]. | | 1992 | 1464095 |
| eradicating helicobacter pylori in patients with duodenal ulcer. | | 1992 | 1467703 |
| helicobacter (campylobacter) pylori in gastric brushing cytology. | helicobacter (formerly campylobacter) pylori is frequently associated with chronic gastritis and peptic ulcer and has been implicated as an etiologic agent. identification of h. pylori is important for specific treatment with antibiotics and bismuth compounds. we studied 27 patients who presented with symptoms of gastritis or peptic ulcer on whom paired gastric biopsies and gastric brushings for cytology had been performed. biopsies were stained with h & e and warthin-starry or giemsa for h. pyl ... | 1992 | 1468331 |
| results of a multicentre european survey in 1991 of metronidazole resistance in helicobacter pylori. european study group on antibiotic susceptibility of helicobacter pylori. | in 1991 a multicentre survey on the prevalence of metronidazole resistance in helicobacter pylori in vitro was carried out in 12 hospitals in 11 different european countries. the susceptibility of helicobacter pylori to metronidazole was determined in each centre by measuring the mic on agar with the pdm e-test (ab biodisk) according to a standard procedure. overall, 122 of 443 (27.5%) strains tested were resistant to metronidazole (mic > 8 micrograms/ml). the level of resistance to metronidazol ... | 1992 | 1468415 |
| the prevalence of helicobacter pylori serum antibodies in children with recurrent abdominal pain. | as part of a large, prospective study we investigated the prevalence helicobacter pylori serum antibodies in children with recurrent abdominal pain (rap). all patients suffered from recurrent bouts of abdominal pain for at least 6 months and ranged in age from 6 to 12 years. h. pylori antibodies were detected using an enzyme-linked immunosorbent assay. the prevalence of h. pylori antibodies in the rap group was compared to that of a control group which consisted predominantly of pre-operative ch ... | 1992 | 1468451 |
| kinetic properties of helicobacter pylori urease compared with jack bean urease. | the urease proteins of the jack bean (canavalia ensiformis) and helicobacter pylori are similar in molecular mass when separated by non-denaturing gradient polyacrylamide gel electrophoresis, both having three main forms. the molecular mass of their major protein form is within the range 440-480 kda with the other two lesser forms at 230-260 kda and 660-740 kda. these forms are all urease active; however, significant kinetic differences exist between the h. pylori and jack bean ureases. jack bea ... | 1992 | 1468614 |
| two weeks treatment with amoxicillin/omeprazole for eradication of helicobacter pylori. | in an open study, 62 patients with helicobacter pylori-associated ulcer disease or functional dyspepsia were treated for two weeks with 2 x 20 mg omeprazole preprandially and 4 x 500 mg amoxicillin suspension one hour before meals and at night. 57 patients (active ulcer disease: n = 53, functional dyspepsia: n = 4) completed the study without contravening the protocol. the rate of eradication of the bacteria at least 4 weeks after cessation of study medication was 82.5% (47/57 patients). three p ... | 1992 | 1471383 |
| helicobacter pylori infection in an hiv-positive patient. | | 1992 | 1472348 |
| [modified selective medium for isolation of helicobacter pylori]. | to improve the detection rate of helicobacter pylori, many kinds of media were tried and other antibiotics were incorporated according to the antimicrobial susceptibility patterns of clinical isolates in our hospital. we found that brain heart infusion agar supplemented with 1% isovitalex and 5% sheep blood, containing nalidixic acid 10 micrograms/ml, vancomycin 6 micrograms/ml, amphotericin b 2 micrograms/ml and polymixin b 16 micrograms/ml (bnvp) or colistin 5 micrograms/ml (bnvc) inhibited th ... | 1992 | 1473370 |
| is there a place for antacids in the treatment of helicobacter pylori infection? | two pilot studies were performed to determine whether aluminium-containing antacids may have a place in the treatment of helicobacter pylori infection. the urease activity of h. pylori is cytopathic to gastric epithelium, and inhibition of this enzyme may have therapeutic potential. in the first study 24 subjects, 12 of which were infected with h. pylori, were given 1 tablet of chewable aluminium hydroxide-containing antacids 10 min before a 14c-urea breath test. gastric urease activity was supp ... | 1992 | 1475615 |
| eosinophil cationic protein and phospholipase a2 activity in human gastric juice. with emphasis on helicobacter pylori status and effects of antacids. | to elucidate possible new effects of antacids, gastric juice from 15 volunteers with known helicobacter pylori status were analysed for eosinophil cationic protein (ecp), phospholipase a2 (pla2) activity, phosphatidylcholine (pc), and bile acids (ba) before and after administration of one tablet of antacid or placebo in a double blind cross-over design. geometric mean ecp concentrations were more than 13 times higher in gastric juice from h. pylori-positive (12.9 micrograms/l) than from h. pylor ... | 1992 | 1475616 |
| omeprazole therapy for helicobacter pylori infection. | to determine whether omeprazole eradicates helicobacter pylori infection of the gastric antrum, six adolescents and one adult with h. pylori colonization of the antrum were entered into a clinical, open trial of medical therapy. histologic evidence of antral gastritis and three complementary methods to document h. pylori colonization of the stomach (silver stain, urease testing, and culture of antrum) were obtained before and after an 8-week course of omeprazole. in vitro susceptibility to omepr ... | 1992 | 1475617 |
| [ulcer epidemiology: old knowledge in a new light]. | low standards of hygiene lead to frequent gastric infection by helicobacter pylori (hp) during early childhood and, subsequently, the development of diffuse atrophic gastric. atrophic gastric in conjunction with environmental factors, such as high dietary salt and low consumption of fruits or vegetables, promote intestinal metaplasia of the gastric mucosa and, possibly, gastric cancer. under improved standards of hygiene, hp is contracted only during adulthood, and gastric atrophy becomes less m ... | 1992 | 1475768 |
| [diagnosis of peptic ulcer disease]. | today the upper gastrointestinal endoscopy is the diagnostic tool of choice to detect peptic gastroduodenal lesions. in case of substantial gastric outlet obstruction or strong suspicion of perforated ulcer, an upper gi-transit with barium or water soluble contrast medium in suspected perforated ulcers may be useful. gastric ulcers are endoscopically controlled up to their complete healing and biopsies taken at each endoscopy in order to rule out gastric cancer. in contrast, duodenal ulcers are ... | 1992 | 1475769 |
| [pathophysiology of ulcer disease]. | the pathogenesis of ulcer disease is complex. the present outline focuses on four main aspects: 1) the mechanisms governing acid production and the role of acid in ulcer disease. 2) the mechanisms regulating mucosal resistance to injury. 3) the association of ulcer disease with antral gastritis and helicobacter pylori infection. 4) ulcer disease and non-steroidal antiinflammatory drugs (nsaids). the complex mechanisms underlying maintenance of mucosal integrity in the normal state and in ulcer d ... | 1992 | 1475770 |
| [prevention of recurrence of ulcer disease: indications and choice of procedure]. | in this contribution we discuss the relapse prophylaxis of ulcers by nonmedicamentous measures, by long-term drug therapy and, in particular, with inhibitors of secretion, by eradication therapy of helicobacter pylori and by surgical therapy. besides secondary prophylaxis (prevention of ulcer relapses), primary prophylaxis (prevention of the first episode) is also briefly treated. | 1992 | 1475772 |
| [future perspectives of ulcer therapy]. | anti-ulcer drugs are amongst the world's most successful pharmaceutical products. whilst the market for histamine h2 antagonists is maturing, that for proton pump inhibitors looks set to expand considerably during the 1990s. indeed, by analogy with anti-hypertensive therapy, enzyme inhibitors could eventually supersede receptor antagonists for the treatment of acid-related diseases. whether a third major cycle of innovative drugs will follow the cimetidine and omeprazole led discoveries of the 1 ... | 1992 | 1475774 |
| evaluation of new anti-infective drugs for the treatment of gastritis and peptic ulcer disease associated with infection by helicobacter pylori. infectious diseases society of america and the food and drug administration. | helicobacter pylori is a gram-negative, microaerophilic, spiral bacillus. infection by this organism is currently believed to be the major cause of type b gastritis. inflammation and infection may persist for years in the absence of therapeutic intervention. there is currently no approved antimicrobial therapy for gastritis. clinical investigations have shown that combination regimens including bismuth salts and antimicrobial drugs result in the relief of symptoms, the resolution of histologic e ... | 1992 | 1477242 |
| [is detection of helicobacter pylori in a patient with 2/3 gastrectomy 6 years ago for stomach cancer, a risk factor for development of tumor recurrence and is therefore a candidate for pathogen eradication?]. | | 1992 | 1478835 |
| helicobacter pylori, gastritis, and peptic ulceration in the elderly. | to determine the histopathological types of gastritis, presence of h pylori, and of peptic ulceration in patients aged 70 and over, compared with younger adults. | 1992 | 1479032 |
| halitosis and helicobacter pylori. a possible link? | the exact pathophysiological mechanism of halitosis is not clear, and in many patients the etiology is an enigma. we followed three couples in which one member or both had halitosis. all the subjects had evidence of helicobacter pylori infection. all received a treatment course of colloidal bismuth subcitrate four times a day and 250 mg metronidazole three times a day. there was impressive improvement in their symptoms, the halitosis disappearing along with eradication of the organism. we call t ... | 1992 | 1479169 |
| [modified combined omeprazole/amoxicillin therapy for helicobacter pylori eradication: a pilot study]. | patients with h.pylori positive peptic ulcer disease were treated with a two weeks regimen consisting of 20 mg omeprazole twice daily and 500 mg amoxicillin six times daily. subsequently, an h2-receptor antagonist was started (300 mg ranitidine) at night time for four weeks. before and one month after completion of antibiotic therapy an upper gi-tract endoscopy was performed for determination of h.pylori infection [biopsy urease test (but), specific culture and histologic demonstration]. a total ... | 1992 | 1479866 |
| chronic erosions of the antral mucosa: a sequela of helicobacter pylori-induced gastritis. | the etiopathogenesis of chronic erosions of the antral mucosa still remains to be clarified. in order to investigate the question as to whether chronic erosions might be a sequela of helicobacter pylori-induced gastritis, we submitted biopsy material obtained from 250 patients with chronic erosions of the antral mucosa to a histological evaluation. the grading of helicobacter pylori colonisation, and gastritis was compared with the results of histological evaluation of the biopsy material obtain ... | 1992 | 1481549 |
| [eradicate helicobacter pylori at any price?]. | | 1992 | 1483613 |
| [prevalence of helicobacter pylori in gastric pathology in aragon]. | the aim of this study was to evaluate the prevalence of helicobacter pylori in 400 patients referred for upper digestive tract endoscopy. in our area it hasn't developed yet any epidemiologic study about this disease. helicobacter pylori was observed in 281 of the 400 patients studied (70%). no significant differences by sex were found in the subjects analyzed. there was a rise in the percentage of positivities as age increased. helicobacter pylori were positive in 74 of the 88 patients with chr ... | 1992 | 1485982 |
| [helicobacter pylori in our country]. | | 1992 | 1485996 |
| review article: urease, gastric ammonium/ammonia, and helicobacter pylori--the past, the present, and recommendations for future research. | the presence of ammonium in gastric contents was described in 1852; urease activity in the stomach was identified 70 years later. the discovery of gastric urease resulted in intense research activity to discover its origin, function, and relation to the gastric levels of ammonium and urea. interest in urease waned in the 1960s as most pertinent questions appeared to have been addressed and there was strong evidence that gastric urease was not a property of the stomach but was of microbial origin ... | 1992 | 1486153 |
| short report: omeprazole plus antibiotic combinations for the eradication of metronidazole-resistant helicobacter pylori. | twenty-eight helicobacter pylori-positive patients with metronidazole-resistant isolates and 25 with metronidazole-sensitive isolates were treated for 14 days with 40 mg omeprazole nocte plus 500 mg amoxycillin t.d.s. eradication of h. pylori, defined as absence of the organism one month after cessation of treatment, was assessed using the [14c]urea breath test. the eradication rate in patients with metronidazole-resistant isolates was 14/28 (50%) while that in patients was metronidazole-sensiti ... | 1992 | 1486161 |
| field evaluation of a rapid, simple and inexpensive urease test for the detection of helicobacter pylori. | a modified rapid urease test (mru test) for the detection of helicobacter pylori was evaluated under field conditions during an endoscopic survey in rural india and compared with a commercially available urease test (clo test) and with histology. of 195 consecutive subjects who underwent upper gastrointestinal endoscopy, 153 (78.5%) were positive for helicobacter pylori when tested by the clo test and/or histology. the sensitivity and specificity of the mru test relative to this was 97.4 and 95. ... | 1992 | 1486185 |
| helicobacter pylori: a risk and severity factor of non-steroidal anti-inflammatory drug induced gastropathy. | this prospective study aimed to determine the prevalence of helicobacter pylori infection in relation to the occurrence and severity of nsaids induced gastropathy. a total of 111 patients were studied-66 were taking nsaids and 45 were control patients. all patients underwent endoscopy during which antral biopsy specimens were taken to determine h pylori status (gram and giemsa staining, urease test, and cultures). the nsaid group comprised: group i, patients without mucosal damage (n = 28); grou ... | 1992 | 1487160 |
| role of ammonia in the pathogenesis of the gastritis, hypergastrinaemia, and hyperpepsinogenaemia i caused by helicobacter pylori infection. | studies were performed in patients with and without renal failure to investigate the role of bacterial ammonia production in the pathogenesis of the mucosal abnormalities caused by helicobacter pylori. the high rate of h pylori ammonia production in uraemic patients should accentuate any ammonia induced effects. the median (range) gastric juice ammonium concentration in the h pylori positive patients with renal failure was 19 mmol/l (ii-43) compared with 5 mmol/l (1-11) in the h pylori positive ... | 1992 | 1487161 |
| identification of formyl met-leu-phe in culture filtrates of helicobacter pylori. | helicobacter pylori synthesizes and secretes a substance which co-chromatographs and is antigenically cross-reactive with the bacterial chemotactic peptide fmet-leu-phe. using reverse phase and affinity chromatography this substance has now been purified. carboxypeptidase y microsequencing has verified that this material is fmet-leu-phe. the infiltration of polymorphonuclear leucocytes to sites of h. pylori infection may be a response to mucosal permeation of soluble, diffusable bioreactive subs ... | 1992 | 1488023 |
| [combined treatment of helicobacter pylori infection--7-day or 14-day treatment?]. | | 1992 | 1488348 |
| helicobacter pylori and gastroduodenal disease. | | 1992 | 1488659 |
| clotest (rapid urease test) in the diagnosis of helicobacter pylori infection. | over a period of 3 months, 85 patients who underwent gastroscopy had antral biopsy taken for clotest, histology and/or culture for helicobacter pylori (hp). the sensitivity and specificity of clotest were found to be 77% and 96% respectively with negative predictive value of 63% and positive predictive value of 98%. ninety-two percent of the positive clotests were positive within 20 minutes, thus giving rapid result. therefore, clotest is a rapid, sensitive and highly specific test for hp infect ... | 1992 | 1488662 |
| evaluation of therapies in the treatment of helicobacter pylori associated non-ulcer dyspepsia. | this randomised double blind placebo controlled study evaluated the effectiveness of colloidal bismuth subcitrate (cbs), ampicillin and their combination in the treatment of helicobacter pylori in non-ulcer dyspepsia (nud) and assessed if elimination of this organism is associated with improvement of gastritis and the symptoms. forty-eight nud patients with h. pylori and histologic gastritis were randomly allocated to one of the three regimens for 28 days. symptoms were assessed before and after ... | 1992 | 1488663 |
| 16s rrn gene copy number in helicobacter pylori and its application to molecular typing. | the copy number of the genes encoding 16s ribosomal rna was analysed for the genomes of geographically diverse strains of helicobacter pylori, and restriction site variation within and around the genes was characterized. a dna probe of 550 bp was amplified by the polymerase chain reaction from genomic dna of the type strain nctc 11637. this probe constituted a sequence internal to the 3' end of the 16s rrn gene. homology profiles were compared for genomic southern blots made with four restrictio ... | 1992 | 1490911 |
| [frequency of helicobacter pylori in chronic gastritis with endoscopically defined erosion]. | the frequency of helicobacter pylori was histopathologically evaluated in biopsy specimens of the gastric mucosa from 112 patients which endoscopically diagnosed as erosion. the specimens, histopathologically diagnosed as chronic gastritis, were divided into eight groups according to age, sex and location. the helicobacter pylori infection was revealed in 65% of all specimens observed, and the frequency in patients of their sixties was lower than that of the forties. the frequency in the elder w ... | 1992 | 1491463 |
| helicobacter (aka campylobacter) pylori as the major causal factor in chronic hypochlorhydria. | helicobacter (formerly known as campylobacter) pylori, a recently discovered gastrointestinal bacterial pathogen, has been shown to be etiologic for type b or antral gastritis, and usually has chronic active pathological changes associated with its presence. acute helicobacter infection in most cases induces reduced stomach acid secretion which usually returns to normal levels of secretion after a few months. yet helicobacter gastritis has never been known to spontaneously remit after it has bee ... | 1992 | 1494326 |
| [current pathogenetic principles in peptic ulcer]. | new concepts in the pathophysiology of peptic ulcers must acknowledge 1. the close association of ulcers and helicobacter pylori infection, 2. the protective role of endogenous prostaglandins, 3. the scarcity of new data on the importance of acidity (though presence of gastric acid remains indispensible for ulcer development). the different pathophysiologically relevant factors closely interact with each other. however, many not of actual concepts are still experimental and--apart from helicobac ... | 1992 | 1496202 |
| blood ammonia and helicobacter pylori. | | 1992 | 1497562 |
| autoimmune gastritis: is helicobacter pylori a merely commensal or a pathogenic agent? | | 1992 | 1499458 |
| helicobacter pylori, musings from the epidemiologic armchair. | the literature on helicobacter pylori has become enormous, but the epidemiology of the infection remains an enigma. guided by epidemiologic principles we have tried to interpret the available data on the epidemiologic aspects of h. pylori. we conclude that conflicting results on familial clustering and seroprevalence curves might have logical explanations. however, the exact way this organism spreads among humans remains to be solved. | 1992 | 1499674 |
| helicobacter pylori infection and gastric function in patients with chronic idiopathic dyspepsia. | helicobacter pylori infection, histological features of the gastric mucosa, and gastric motor and secretory functions were evaluated in 45 consecutive patients with chronic idiopathic dyspepsia. h. pylori infection was found in 60% of dyspeptic patients, compared with 33% of 15 healthy controls (p = 0.1). no difference was detected in basal or stimulated gastric acid secretion between dyspeptic patients and healthy controls. gastric emptying was significantly (p less than 0.01) delayed in dyspep ... | 1992 | 1499926 |
| helicobacter pylori in hispanics: comparison with blacks and whites of similar age and socioeconomic class. | helicobacter pylori infection is twice as frequent in blacks as in whites. it has been postulated that the apparent increase in susceptibility to h. pylori infection in blacks might have a genetic basis. a case-control seroepidemiologic study of h. pylori prevalence was performed in 108 healthy hispanic volunteers. eighty-nine hispanics were matched (1:1:1) with blacks and whites for age and socioeconomic status. there was an inverse correlation between h. pylori infection and educational level ... | 1992 | 1499931 |
| selection of the chimpanzee over the baboon as a model for helicobacter pylori infection. | baboons (papio sp.) and chimpanzees (pan troglodytes) were screened for the presence of helicobacter pylori. the gastric mucosae of the baboons were colonized by large spiral bacteria. however, a group of adult chimpanzees were identified that were free of spiral gastric bacteria, with five animals being recruited into an h. pylori challenge study. these animals were inoculated orogastrically with one of four strains of h. pylori and followed for up to 26 weeks. h. pylori was established in one ... | 1992 | 1499934 |
| characteristics of helicobacter pylori variants selected for urease deficiency. | the urease of helicobacter pylori is suspected to play a role in the pathogenesis of gastritis. although all clinical isolates of h. pylori are urease positive (u+), we have selected and characterized several spontaneously arising urease-negative (u-) variants from wild-type strain 60190. urease-negative variants were identified by growth in medium containing 60 mm urea and arose at a frequency of 10(-5) to 10(-6). the urease activity of the wild-type strain inhibited growth of this strain in th ... | 1992 | 1500174 |
| helicobacter pylori-related hypergastrinaemia is not due to elevated antral surface ph. studies with antral alkalinisation. | it has been postulated that helicobacter pylori-related hypergastrinaemia is due to bacterial ammonia raising antral surface ph and thus preventing acid inhibition of gastrin release. if true, the infection should not alter gastrin release at neutral intragastric ph. to test this, we have studied basal and meal-stimulated gastrin at uncontrolled ph and at ph greater than 6 in duodenal ulcer patients before and after eradication of h. pylori. the median integrated gastrin response to the meal alo ... | 1992 | 1502485 |