| smoking does not contribute to duodenal ulcer relapse after helicobacter pylori eradication. | cigarette smoking is believed to be one of the major factors influencing duodenal ulcer (du) recurrence. however, the influence of cigarette smoking on du recurrence after the eradication of helicobacter pylori has not been separately addressed. the aim of this study was to investigate du relapse rate in smokers and nonsmokers, both with confirmed eradication of h. pylori. patients with h. pylori eradication, demonstrated at endoscopy 4 wk post-treatment, were included in the study. smoking hist ... | 1992 | 1415092 |
| nonsteroidal antiinflammatory drug-associated gastric ulcers do not require helicobacter pylori for their development. | nonsteroidal antiinflammatory drugs (nsaids) have been linked with a high incidence of ulcer complications. histologic gastritis is present in most patients with standard peptic ulcers, and this gastritis is generally related to helicobacter pylori (hp). we questioned whether gastric ulcers associated with nonsteroidal antiinflammatory drugs (nsaids) develop via a novel mechanism, distinct from the usual hp-gastritis-ulcer diathesis. two groups of patients with newly discovered gastric ulcers we ... | 1992 | 1415094 |
| helicobacter pylori-negative gastric ulcer. | causes of helicobacter pylori (hp)-negative gastric ulcers (gus) have not previously been systematically studied. in this study we examined possible causes of hp-negative gus. among 115 consecutive patients with endoscopic diagnoses of gu, 71 (62%) had hp infection, and 44 (38%) were found to be hp-negative. of the 71 hp-positive patients, 47 (66%) had no other detectable causal factors, 21 (30%) were regularly taking nonsteroidal antiinflammatory drugs (nsaids), and three (4%) had malignant gu. ... | 1992 | 1415095 |
| bleeding from a meckel's diverticulum after the use of ibuprofen. | a meckel's diverticulum is an unusual site of gastrointestinal bleeding in adults. bleeding often results from ulceration of ileal mucosa that lies adjacent to ectopic gastric mucosa. we report on a 27-yr-old man who bled from a meckel's diverticulum after receiving oral ibuprofen, a nonsteroidal antiinflammatory drug. examination of the resected diverticulum revealed fundal-type gastric mucosa with inflammation, submucosal hemorrhages, erosions and ulceration in the absence of helicobacter pylo ... | 1992 | 1415106 |
| source of helicobacter pylori infection: studies in abattoir workers and pigs. | | 1992 | 1415120 |
| decreased level of antibodies against helicobacter pylori in patients with rheumatoid arthritis receiving intramuscular gold. | sodium aurothiomalate has been reported to have in vitro activity against helicobacter pylori. intramuscular gold, as given to patients with rheumatoid arthritis (ra), may therefore influence the colonisation of the gastric mucosa with h pylori. | 1992 | 1417132 |
| effect of helicobacter pylori lipopolysaccharide on the synthesis of sulfated gastric mucin. | the effect of h. pylori lipopolysaccharide on the synthesis and secretion of sulfated mucus glycoprotein in gastric mucosa was investigated. the lipopolysaccharide, while showing no discernible effect on the apomucin synthesis, exerted a profound inhibitory effect on the process of mucus glycoprotein glycosylation and sulfation, and evoked a rapid (within 15 min) inhibition (65%) in both mucin glycosylation and sulfation at its optimal concentration of 100 micrograms/ml. the data on mucin secret ... | 1992 | 1417902 |
| experience with 'triple' anti-helicobacter pylori eradication therapy: side effects and the importance of testing the pre-treatment bacterial isolate for metronidazole resistance. | at the 1990 world congresses of gastroenterology, the working party on helicobacter pylori (h. pylori) recommended that, in suitable patients, the bacterium should be eradicated using a therapeutic regimen comprising a bismuth salt, tetracycline and metronidazole for two weeks. we have treated 40 patients infected with h. pylori with 'triple' therapy consisting of 120 mg tripotassium dicitrato bismuthate q.d.s., 500 mg tetracycline q.d.s. and 400 mg metronidazole t.d.s. for two weeks. the succes ... | 1992 | 1420735 |
| short report: cefprozil for the eradication of helicobacter pylori infection. | helicobacter pylori infection has proven to be extraordinarily difficult to eradicate. antimicrobial monotherapies have been particularly disappointing, with most eradication rates in the range of 0 to 15%. we evaluated cefprozil (250 mg q.d.s. for 14 days) in 12 h. pylori-infected subjects. the 13c-urea breath test was used to evaluate effectiveness of therapy. eradication was defined as a negative urea breath test 4 to 6 weeks after the end of treatment. suppression of h. pylori was demonstrat ... | 1992 | 1420742 |
| clinicopathological assessment of gastric biopsy samples of patients with helicobacter pylori infection--metronidazole resistance and compliance problems in the united arab emirates. | the significance of helicobacter pylori (hp) infection was assessed prospectively in forty-two patients with dyspepsia using histological, bacteriological and biopsy urease techniques. thirty-eight patients (90.5%) were positive for hp infection and were treated with bismuth subcitrate (de nol), tinidazole and doxycycline. hp was present in the antrum, corpus, fundus, duodenum and gastric juice in 36, 26, 23, 2 and 2 patients respectively (p < 0.01, x2 test). histological assessment yielded more ... | 1992 | 1421445 |
| prevalence of gastritis in patients with acromegaly: untreated and during treatment with octreotide. | it has previously been suggested that acromegalic patients treated with the somatostatin analogue octreotide invariably have chronic gastritis. we have examined the prevalence of gastritis in a large group of acromegalic patients, untreated and during treatment with octreotide. | 1992 | 1424205 |
| [helicobacter pylori-associated gastritis and low-malignancy malt lymphoma]. | | 1992 | 1425268 |
| [helicobacter pylori: the local iga response of the gastric mucosa]. | | 1992 | 1425270 |
| [helicobacter pylori and gastric carcinoma]. | | 1992 | 1425302 |
| evaluation of a monoclonal antibody for detection of helicobacter pylori in a direct immunofluorescence test. | a monoclonal antibody was developed for detection of helicobacter pylori in gastric tissue sections in a direct immunofluorescence test. on a comparison of the immunofluorescence test with standard methods for detection of helicobacter pylori, i.e. culture, the urease activity test and histological examination of tissue sections, using 158 biopsy specimens, 30 specimens were positive in all methods and 64 negative. in the remaining cases comparison was not possible because either immunofluoresce ... | 1992 | 1425734 |
| surface hydrophobicity of gastric mucosa in helicobacter pylori infection: effect of clearance and eradication. | surface hydrophobicity of the gastric mucosa is reduced in peptic ulcer disease and helicobacter pylori infection. this abnormality may be caused by h. pylori or may be an inherent defect. the aim of the present study was to clarify the relationship between h. pylori infection and mucosal hydrophobicity by examining the effect of eradication of the organism. h. pylori-positive patients with (n = 42) or without (n = 42) duodenal ulcer were randomized to receive ranitidine, bismuth, or bismuth plu ... | 1992 | 1426866 |
| chronic active gastritis due to helicobacter pylori in immunized gnotobiotic piglets. | in gnotobiotic piglets, parenteral vaccination with formalin-killed helicobacter pylori and oral vaccination with live bacteria induced h. pylori-specific serum immunoglobulins g, m, and a. vaccination reduced but did not prevent infection by subsequent challenge with viable h. pylori. oral vaccination with killed bacteria was less effective in inducing serum antibody and had no effect on bacterial colonization. immunization status influenced the histologic response of piglets to challenge by h. ... | 1992 | 1426878 |
| eradication of helicobacter pylori reduces gastric and duodenal ulcer recurrence. | | 1992 | 1426890 |
| mucosal peptic activity during helicobacter pylori infection in pediatric patients. | intramucosal peptic activity may participate in the genesis of acute and chronic superficial gastritis. the proteolytic activity of homogenates of gastric mucosa (antrum and body) and duodenum were measured at ph 2.0 (total peptic activity) after exposure to ph 8.0 (pepsinogen) and the activated pepsinogen (pepsin) was calculated in pediatric patients investigated for the presence of helicobacter pylori (h pylori), 122 antral, 77 stomach body, and 74 duodenal biopsies were examined in 43 h pylor ... | 1992 | 1427366 |
| helicobacter pylori and peptic ulcer recurrence. | | 1992 | 1427384 |
| helicobacter pylori and peptic ulcer recurrence. | | 1992 | 1427385 |
| epithelial degeneration induced by helicobacter pylori. | | 1992 | 1427763 |
| does helicobacter pylori cause gastric cancer? | | 1992 | 1428029 |
| a study of helicobacter pylori in north indian subjects with non-ulcer dyspepsia. | a prospective case control study was conducted in 50 patients with non-ulcer dyspepsia (nud) and 10 age and sex matched controls to determine the prevalence of helicobacter pylori in patients with nud and to correlate symptoms, histology and presence of h pylori in gastric biopsies. endoscopic biopsies from antrum and fundus were subjected to urease test and histological examination. on histology, h pylori was identified in 27 (54%) nud patients and in one of 10 controls. urease test was positiv ... | 1992 | 1428036 |
| [dynamics of neutrophils in the gastric mucous layer of helicobacter pylori associated chronic gastritis]. | | 1992 | 1431391 |
| surfactant-like material in the antral gastric mucosa of children. | it has been proposed that the hydrophobicity of the gastric mucosa is due to surfactant-like material (slm), mainly composed of phospholipid, adsorbed to the mucosal surface. biochemical and physiological studies have been performed in different mammals but morphological data on children are lacking. in the present work, the presence of slm on the antral gastric mucosa of children has been studied by electron microscopy. the results demonstrate that slm is present and shows two different forms, ... | 1992 | 1432465 |
| [prognostic significance of cytochemical and functional activity of blood lymphocytes in patients with peptic ulcer and the presence of helicobacter pylori]. | | 1992 | 1434395 |
| colloidal bismuth subcitrate and omeprazole inhibit alcohol dehydrogenase mediated acetaldehyde production by helicobacter pylori. | we have recently shown that helicobacter pylori possesses marked alcohol dehydrogenase (adh) activity and is capable--when incubated with an ethanol containing solution in vitro--of producing large amounts of acetaldehyde. in the present study we report that some drugs commonly used for the eradication of h. pylori and for the treatment of gastroduodenal diseases are potent adh inhibitors and, consequently, effectively prevent bacterial oxidation of ethanol to acetaldehyde. colloidal bismuth sub ... | 1992 | 1435071 |
| cloning and genetic characterization of a helicobacter pylori flagellin gene. | helicobacter pylori produces polar sheathed flagella, which are believed to be essential for the bacterial colonization of the human gastric mucosa. here we report on the cloning and genetic characterization of a h. pylori gene encoding the subunit of the flagellar filament, the flagellin. screening of a genomic library of h. pylori with an oligonucleotide probe derived from the n-terminal amino acid sequence of purified flagellin resulted in a recombinant plasmid clone carrying the flagellin-en ... | 1992 | 1435261 |
| [effect of colloid bismuth treatment on campylobacter pylori infection of the gastric mucosa and the clinical course of non-ulcer dyspepsia]. | there are suggestions, that the idiopathic non-ulcer dyspepsia is related to the chronic gastritis type b coexisting with c. pylori infection. presented studies were aimed at the assessing of an effect of the treatment with de-nol on the course of the idiopathic non-ulcer dyspepsia of c. pylori infection. gastroscopic examination was performed in 52 patients with non-ulcer dyspepsia before and after the treatment with de-nol administered for 4-8 weeks. campylobacter pylori was isolated from 71% ... | 1992 | 1437790 |
| [inflammatory changes in the gastric mucosa of patients with idiopathic non-ulcer dyspepsia and the effect of colloid bismuth treatment on the course of inflammation]. | the studies were aimed at the assessment of the coexistence of non-ulcer dyspepsia with chronic gastritis and campylobacter pylori infection, and of the effect of therapy with de-nol on the course of such disease. the studies involved 50 patients with non-ulcer dyspepsia. prior to and after the treatment with de-nol samples of the mucosa collected from the antrum and corpus of the stomach have been examined histologically with urease test indicating c. pylori infection. chronic gastritis of the ... | 1992 | 1437791 |
| eradication of helicobacter pylori: therapies and clinical implications. | this review presents a critical evaluation of the role of helicobacter pylori eradication in the management of peptic ulcer disease and non-ulcer dyspepsia. on current evidence, h. pylori eradication therapy seems likely to emerge as the most rational and cost-effective treatment for duodenal ulcer. the role of h. pylori eradication in the treatment of gastric ulcer and non-ulcer dyspepsia is unclear and requires further study. the emerging problem of antibiotic resistance in h. pylori is of maj ... | 1992 | 1437952 |
| [prevalence of helicobacter pylori in patients with gastric cancer in panama]. | cancer of the stomach is the second in incidence in panama after the cancer of the prostata. it is studied now the incidence of infection due to helicobacter pylori in patients with gastric carcinoma. it seems to be a significative relationship between the prevalence of gastric carcinoma and h. pylori infections. this observation is important because by the similar therapeutic implications in virus dna hepatitis type b and hepatoma. | 1992 | 1439007 |
| [classification of gastritis according to the sydney system]. | | 1992 | 1439431 |
| effect of helicobacter pylori on parietal cell sensitivity to pentagastrin in duodenal ulcer subjects. | we have investigated the possibility that hypergastrinaemia in chronic helicobacter pylori infection is a compensatory response to reduced parietal cell sensitivity to gastrin. the acid response to 45-min infusions of pentagastrin at sequential doses (micrograms/kg/h) of 0, 0.031, 0.062, 0.124, and 0.6 was compared before and 1 month after eradication of h. pylori in eight duodenal ulcer patients. the median acid outputs (mmol/h) with the respective infusions were 5.0, 7.5, 26.5, 30.8, and 37.0 ... | 1992 | 1439539 |
| [the rational use of de-nol in the treatment of peptic ulcer and chronic active gastroduodenitis associated with helicobacter pylori]. | | 1992 | 1440381 |
| helicobacter pylori and non-ulcer dyspepsia. | | 1992 | 1440895 |
| [the efficacy of treating peptic ulcer patients with trichopol and dalargin]. | a study of 90 patients with endoscopically proved duodenal ulcer revealed that dalargin and trichopol+dalargin treatment resulted in early scarring of the ulcer and control of gastroesophageal and duodenogastric reflux in the majority of patients. gastroduodenitis symptoms were not eliminated in a half of all patients. it was shown that persistent manifestations of gastroduodenitis remained in patients with a pronounced pyloric helicobacteriosis and a high titer of antibodies to cells of the gas ... | 1992 | 1441328 |
| [therapy of stomach ulcer--a comparison between the low dosage antacid hydrotalcite and ranitidine--results of a randomized multicenter double-blind study. talcivent study group]. | in a 8 week double-blind randomized multicenter trial in 159 patients with benign gastric ulcer the efficacy of hydrotalcite vs. ranitidine in expediting ulcer healing and in achieving pain relief was determined. 79 patients received hydrotalcite 1000 mg q.i.d. as tablets equalling a total neutralizing capacity of 111.2 mval and 80 patients received ranitidine (300 mg at night). endoscopically controlled healing rates after 4 weeks of therapy amounted to 41.8% with hydrotalcite and 53.8% with ra ... | 1992 | 1441674 |
| active autoimmune gastritis without total atrophy of the glands. | to date, autoimmune gastritis has been diagnosed for the most part only when total atrophy of the oxyntic glands is detected. on the basis of 40 patients without total atrophy of the glands, and with parietal cell antibodies in the serum, we show that the diagnosis of type a gastritis is also possible in the pre-atrophic stage. the histological criteria for the diagnosis of active autoimmune gastritis without total atrophy of the glands are 1. usually dense, diffuse locally emphasized lymphocyti ... | 1992 | 1441676 |
| helicobacter pylori, gastritis, and ulcers in pediatrics. | hp now appears to be more than a simple commensal organism in patients with gastritis or peptic ulcer disease. microbiologic, serologic, and epidemiologic studies all confirm that hp has an important role in children with abdominal pain. hp is found in the gastric mucosa of children with histologically proven gastritis or peptic ulcer. the organism can be transmitted from human to human with evidence of colonization, appearance of gastritis, and serum antibody response. antimicrobial therapy dir ... | 1992 | 1442315 |
| role of helicobacter pylori in gastritis and duodenitis in man. | although helicobacter pylori is now accepted as the major aetiological factor in chronic gastritis in man, many of the factors which determine its pathogenicity are unknown. the organism has adapted to survive in the low-ph environment of the stomach, partly through its ability to buffer hydrogen ion by the hydrolysis of urea and by the presence of lectins on its surface, which bind to gastric mucosa and epithelial cells. after attachment, harmful toxins and enzymes have access to the gastric ce ... | 1992 | 1442334 |
| h. pylori causes cancer: true or false? | | 1992 | 1442669 |
| high prevalence and persistence of cytotoxin-positive helicobacter pylori strains in a population with high prevalence of atrophic gastritis. | helicobacter pylori is strongly associated with both chronic gastritis and duodenal ulcer. certain strains of h. pylori produce a vacuolating cytotoxin in vitro. at new orleans charity hospital, concentrated culture supernatants from 119 of 144 (83%) h. pylori strains isolated from 86 patients at high risk of developing gastric cancer, caused vacuolization in hela s3 cells. cytotoxin activity was neutralized by acid (ph 4) and basic (ph 10) solutions and proteases, and was precipitable by (nh4)2 ... | 1992 | 1442673 |
| prevalence and significance of helicobacter pylori in patients with barrett's esophagus. | a retrospective study for assessment of the prevalence of helicobacter pylori was performed in 107 consecutive patients with columnar-lined epithelium in the esophagus. the presence of hiatal hernia and esophagitis was noted. from 71 patients, biopsy specimens were available for analysis. no difference in the presence or absence of h. pylori was noted, regardless of whether or not there was esophagitis or hiatal hernia. most h. pylori-positive patients show a low bacterial load in the metaplasti ... | 1992 | 1442681 |
| natural history of erosive duodenitis. | | 1992 | 1442706 |
| helicobacter pylori-associated ammonia production enhances neutrophil-dependent gastric mucosal cell injury. | the role of neutrophil and its chlorinated oxidant were investigated in helicobacter pylori-induced gastric mucosal injury in vitro. luminol-dependent chemiluminescence (chl) was used to detect neutrophil-derived oxidants. chl activity was significantly elevated when neutrophils were incubated in h. pylori, indicating that h. pylori actually elicits oxidative burst of neutrophils. to assess whether h. pylori-activated neutrophils exert the cytotoxicity for gastric mucosal cells, rabbit gastric m ... | 1992 | 1443147 |
| genetics of campylobacter and helicobacter. | this article reviews the current state of genetic analysis of campylobacter and helicobacter. chromosomal genes cloned from campylobacter and helicobacter species are listed along with the method used to identify the cloned gene. campylobacter plasmid genes that have been cloned and expressed in escherichia coli and that specify resistance to tetracycline, kanamycin, or chloramphenicol are presented. this review also examines our current knowledge of genetic exchange in campylobacter, including ... | 1992 | 1444260 |
| a mucosal barrier of gastric surfactant identified in the human stomach. | using a special fixation procedure avoiding glutaraldehyde, an oligolamellar lining has been demonstrated by electronmicroscopy on the luminal surface of the human stomach and, with more lamellations, on the epithelial surfaces of oxyntic ducts and parietal cells. these results indicate that, in the human stomach, there is indeed a gastric mucosal barrier consisting of a multi-laminated structure of surface-active phospholipid (sapl). this gastric surfactant is probably produced in parietal cell ... | 1992 | 1445032 |
| haemagglutination patterns of helicobacter pylori. frequency of sialic acid-specific and non-sialic acid-specific haemagglutinins. | thirty-two helicobacter pylori strains were screened for haemagglutination (ha) activity with erythrocytes of 11 different animal species. twenty-three strains (72%) that agglutinated human erythrocytes exhibited a broad-spectrum ha profile. human, guinea pig and bovine erythrocytes high in sialoglycoconjugates were strongly agglutinated by most strains. except for two, seven strains (22%) that did not agglutinate human erythrocytes exhibited a narrow-spectrum ha profile, commonly not inhibitabl ... | 1992 | 1445697 |
| changing pattern of gastric cancer in oxfordshire. | this study compares the incidence rates of histologically confirmed gastric carcinoma in oxfordshire in two five year periods (1960-64, 1984-88). data were available for 215 patients in the first period, and 200 in the second. the overall incidence fell from 18/100,000 to 15/100,000 but when analysed for site, the incidence of antral tumours fell from 10 to 4.5/100,000. in contrast, there was an increase from 2.8 to 5.2/100,000 of tumours of the cardia. these changes were more pronounced in men. ... | 1992 | 1446851 |
| evidence of clonal variants of helicobacter pylori in three generations of a duodenal ulcer disease family. | nine members of a family with a high incidence of duodenal ulcer disease were studied by interview, examination of hospital records, endoscopy, and antral biopsy. helicobacter pylori was confirmed by clo test, histology and culture. dna extraction from pure isolates of h pylori was possible in six family members and strain typing was performed by restriction fragment length polymorphism. dna restriction digestion was followed by vacublotting and then dna hybridisation, using a cdna probe complim ... | 1992 | 1446853 |
| eighteen month follow up of helicobacter pylori positive children treated with amoxycillin and tinidazole. | sixty three children with dyspepsia (mean age 12 years, range one to 18, m/f 41/22) were helicobacter pylori positive by histology of gastric antral biopsy specimens and were treated with a six week course of amoxycillin (50 mg/kg) and tinidazole (20 mg/kg). the endoscopic diagnoses were: normal (16), nodular gastritis (19), oesophagitis (four), duodenal ulcer (13), and gastric ulcer (11). h pylori was eradicated in 54 (87%) and histological gastritis resolved in 51 and was improved in the other ... | 1992 | 1446854 |
| role of helicobacter felis in chronic canine gastritis. | five gnotobiotic beagle dogs were orally inoculated with a pure culture of helicobacter felis. the remaining two littermates served as contact controls. thirty days after infection, all animals were euthanatized and specimens were collected for evaluation. in infected dogs, h. felis was recovered from all areas of the stomach. colonization was heaviest in the fundus and antrum. h. felis was not cultured from any segment of the gastrointestinal tract distal to the duodenum. two weeks after infect ... | 1992 | 1448894 |
| [immunity and the prostaglandin level in gastritis b]. | the indices of systemic and local immunity, level of prostaglandins, presence of helicobacter pylori in the gastric mucosa was studied in 53 patients with gastritis b. patients with superficial antral gastritis showed independent of the presence of helicobacter pylori in the gastric mucosa changes of the systemic immunity and level of pge2 and pgf1 that were abnormal. in atrophy of the antral gastric mucosa and presence there of h. pylori one observed a reduction of the number of t-lymphocytes a ... | 1992 | 1448980 |
| [the efficacy of antibacterial treatment in chronic gastritis of helicobacter etiology]. | a study of 140 patients with chronic gastritis revealed helicobacter pylori in the gastric antral mucosa in 100% and in the duodenum in 50%. there is a direct correlation between the presence and amount of helicobacter pylori in the mucosa, lymphoplasmocytic infiltration, dystrophic changes of epithelium. ampiox treatment proved beneficial both clinically and morphologically. after treatment helicobacter pylori was absent in 65.7%, in the remaining cases it reduced by 5-10 times. | 1992 | 1448981 |
| meta-analysis of the efficacy of antibiotic therapy in eradicating helicobacter pylori. | despite numerous helicobacter pylori treatment studies, the optimum regimen(s) for its eradication remain unclear. our objective was to determine systematically which regimen(s) gave the best pooled eradication rates, by using meta-analysis methodology. a total of 27 studies were identified. pooled eradication rates for single (18.6%), double (48.2%), and triple therapy (82.3%) were statistically highly different (p < 0.0005). eradication rates with amoxicillin (23.0%) and bismuth compounds (19. ... | 1992 | 1449132 |
| helicobacter pylori infection in dental workers: a seroepidemiology study. | the finding of helicobacter pylori in dental plaque suggested that dental workers may be at increased risk of acquiring h. pylori infection from occupational exposure. a cross-sectional survey of 239 dental workers from 37 texas cities (including 89 dentists, 44 dental hygienists, 98 dental assistants, and eight dental students) was conducted. h. pylori infection was determined by the presence of igg antibodies to h. pylori, using a specific and sensitive elisa. participants ranged in age from 1 ... | 1992 | 1449133 |
| gastric and duodenal mucosal prostaglandin concentrations in gastric or duodenal ulcer disease: relationships with demographics, environmental, and histological factors, including helicobacter pylori. | we measured gastric and duodenal mucosal prostaglandin concentrations in 69 patients with active or inactive duodenal or gastric ulcer disease and 26 non-ulcer controls. each underwent endoscopy enabling us to obtain multiple biopsies from the gastric body and antrum and from the duodenal bulb and postbulbar duodenum for measurement of mucosal prostaglandin concentrations, as well as a single biopsy from each region for mucosal histology. using a multivariate linear regression model, we found th ... | 1992 | 1449136 |
| advantage of use of dpm for 14c-urea breath test for the detection of helicobacter pylori. | | 1992 | 1449167 |
| [mucous membrane of the gastric antrum in late periods after selective proximal vagotomy with surgical drainage of the stomach and duodenum]. | a clinicomorphological analysis was performed of the gastric antrum mucous membrane of 60 patients after selective proximal vagotomy because of stenosing duodenal ulcer. the patients were subdivided into two randomized groups depending on the type of the draining operation. the first group had a gastroduodenoanastomosis for the gastric drainage and the second group underwent duodenum plasty (drainage of the duodenum). discontinuation of the pylorus function in the gastric drainage operation resu ... | 1992 | 1449389 |
| activation of human phagocyte oxidative metabolism by helicobacter pylori. | a characteristic feature of chronic antral gastritis is the abundant inflammatory response in close association with helicobacter pylori, but the immunopathological mechanisms of tissue damage are unknown. because reactive oxygen radicals have been implicated in the tissue damage of other chronic inflammatory disorders, we investigated the potential ability of h. pylori sonicate to influence the oxidative burst responsiveness of human polymorphonuclear leukocytes and monocytes. for both cell typ ... | 1992 | 1451968 |
| dyspepsia, helicobacter pylori, and peptic ulcer in a randomly selected population in india. | there seems to be a worldwide geographic variation in the prevalence of peptic ulcer disease, although there are few reliable population based studies. this study aimed to determine the prevalence of peptic ulcer disease in a community in southern india and to evaluate the relationship between dyspeptic symptoms, helicobacter pylori infection, gastritis, and peptic ulcer disease. a sample population was selected randomly from a rural monastic settlement in southern india. subjects were interview ... | 1992 | 1452068 |
| mucosal reactive oxygen metabolite production in duodenal ulcer disease. | to investigate the hypothesis that reactive oxygen metabolites are important in the pathophysiology of duodenal ulcer disease, their production by duodenal mucosal biopsy specimens was measured using luminol and lucigenin amplified chemiluminescence. luminol chemiluminescence, expressed as background corrected median photon emission/mg/min x 10(3) (95% confidence intervals), was increased in duodenal inflammation as assessed macroscopically: ulcers 20.3 (4.8 to 51.3), n = 29; severe duodenitis 1 ... | 1992 | 1452069 |
| helicobacter pylori infection rates in relation to age and social class in a population of welsh men. | | 1992 | 1452089 |
| [a study on the pathogenicity of helicobacter pylori in chronic gastritis and peptic ulcer disease]. | gastroendoscopic biopsy specimens from 366 patients were stained with he, warthin-starrys or giemsa and mucin histochemical methods. positive rate of helicobacter pylori (hp) was 73.8% in chronic gastritis. positive rates of hp in gastric ulcer disease were 88.2%, 91.9%, and 11.1% at the near and distant mucosa of ulcer and in duodenitis, respectively. positive rates of hp in duodenal ulcer disease were 81.5%, 24.6% and 7.2% at the pyloric-antral area and at the near and distant mucosa of duoden ... | 1992 | 1452159 |
| purification and characterization of the urease enzymes of helicobacter species from humans and animals. | the urease enzymes of helicobacter pylori, h. mustelae, h. felis, and h. nemestrinae have been purified to homogeneity by affinity chromatography and characterized. the native urease enzymes of the four organisms were found to be almost identical, with a pi of 6.1 and molecular masses of 480 to 500 kda, as determined by electrophoretic mobility in nondenaturing polyacrylamide gels. transmission electron microscopy of the native urease showed it to be a molecule approximately 13 nm in diameter, w ... | 1992 | 1452359 |
| comparison of commercial serological tests for detection of helicobacter pylori antibodies. | serological testing for helicobacter pylori infection is one of the diagnostic methods of choice. various commercial kits that use different antigens have been developed, but data on their diagnostic accuracy and direct comparisons between the tests are lacking. we aimed to evaluate the sensitivity, specificity, and predictive value of three immunoglobulin g enzyme-linked immunosorbent assay kits: pylori stat, helico-g, and premier h. pylori. serum samples and gastric biopsy findings from 76 pat ... | 1992 | 1452698 |
| evaluation of a commercially available complement fixation test for diagnosis of helicobacter pylori infection and for follow-up after antimicrobial therapy. | commercially available complement fixation test reagents (institute virion ltd., rüschlikon, zurich, switzerland) available in package format were evaluated for the serodiagnosis of helicobacter pylori infection. the assay was compared with bacterial culture and histological giemsa stain of gastric biopsy specimens obtained from 930 patients of different ages and from different ethnic groups, with a variety of upper gastrointestinal tract symptoms. the prevalence, sensitivity, specificity, and p ... | 1992 | 1452707 |
| chronic giardiasis of the stomach. | two cases of chronic giardiasis of the stomach diagnosed from gastric mucosal biopsy specimens are reported. the first case was associated with an acute-on-chronic gastritis and helicobacter-like organisms, and the second with an adenocarcinoma of the stomach. in both cases the trophozoites had been missed in earlier biopsy specimens. as far as is known this is the first report of giardiasis of the stomach. | 1992 | 1452783 |
| gastric giardiasis. | to assess the prevalence of gastric giardiasis in patients undergoing upper gastrointestinal endoscopy, and to define the clinicopathological correlates of gastric giardia lamblia infection. | 1992 | 1452790 |
| clinical implications of serum pepsinogen and progastricsin in man. | the serum pepsinogens in man have been reviewed with respect to clinical and physiological significance. the many places of synthesis of pepsinogen (pg a) and progastricsin (pg c) are described. the major part of serum pepsinogen and progastricsin is synthezized in the stomach, and the findings after antrectomy indicate that the majority of the pepsinogens in serum originates from the corpus of the stomach. the concentrations of pepsinogen and progastricsin in serum in relation to stomach diseas ... | 1992 | 1455183 |
| gastric changes in coronary-operated patients with low-dose aspirin. | low-dose aspirin is widely used in patients operated on for coronary disease as secondary prevention of coronary artery occlusion. the changes caused by aspirin in therapeutic doses to gastric mucosa are well documented, but the effect of long-term low-dose aspirin is not so well known. forty-six volunteer coronary-operated patients with daily low-dose aspirin were interviewed postoperatively, and an upper gastrointestinal tract endoscopy was performed and biopsy specimens taken 3 months after t ... | 1992 | 1455187 |
| observer homogeneity in the histologic diagnosis of helicobacter pylori. latent class analysis, kappa coefficient, and repeat frequency. | four pathologists independently examined 82 antral mucosal biopsy specimens for the presence of helicobacter pylori and indicated whether their assessments were certain. the pathologists made a positive diagnosis in from 56% to 84% of the specimens (significant heterogeneity, p < 0.01). the frequency of uncertain diagnoses was from 4% to 20% (p < 0.01). uncertain statements occurred more frequently among negative than among positive diagnoses. for the six pairs of observers the kappa coefficient ... | 1992 | 1455190 |
| triple therapy of helicobacter pylori infection in peptic ulcer. a 12-month follow-up study of 93 patients. | this study was undertaken to evaluate the success of triple therapy in peptic ulcer patients and ulcer relapses. one hundred and one consecutive helicobacter pylori-positive peptic ulcer patients were assigned to an open trial with 2 weeks of treatment with colloidal bismuth subcitrate, amoxicillin, and metronidazole. at the 6-week follow-up only 1 duodenal ulcer was unhealed of 57 active ulcers, and h. pylori was found to be eradicated in 84% of the 100 subjects. the sensitivity to metronidazol ... | 1992 | 1455197 |
| biometric evaluation of gastric urease activity in man. | the 14c-urea breath test is claimed to be the best test for detection of helicobacter pylori infection. we present a procedure for estimating its cutoff value on the basis of biometric evaluation only, without involving other diagnostic methods. cumulative gastric urease activity (ca) was determined during the first 30 min after oral administration of 14c-urea (92.5 kbq) in 56 random volunteers and 49 consecutive patients with peptic ulcer disease. the distribution of ca in random volunteers was ... | 1992 | 1455198 |
| human gastric carcinogenesis: a multistep and multifactorial process--first american cancer society award lecture on cancer epidemiology and prevention. | evidence from pathology and epidemiology studies has been provided for a human model of gastric carcinogenesis with the following sequential stages: chronic gastritis; atrophy; intestinal metaplasia; and dysplasia. the initial stages of gastritis and atrophy have been linked to excessive salt intake and infection with helicobacter pylori. the intermediate stages have been associated with the ingestion of ascorbic acid and nitrate, determinants of intragastric nitrosation. the final stages have b ... | 1992 | 1458460 |
| ph-dependent secretion of gastrin in duodenal ulcer disease: effect of suppressing helicobacter pylori. | patients with duodenal ulcers and helicobacter pylori infection have elevated plasma gastrin concentrations which fall after suppression of the organism. this may be due to h. pylori elevating the ph of the antral mucous layer, therefore preventing luminal acid from inhibiting gastrin release. to test this idea, we measured the plasma gastrin concentrations under basal conditions and in response to 4% peptone when the gastric lumen was maintained at ph 2.5 and at ph 5.5 by gastric perfusion. we ... | 1992 | 1459351 |
| presence of methylated adenine in gatc sequences in chromosomal dnas from campylobacter species. | we digested chromosomal dnas from 12 campylobacter strains (c. jejuni, 4 strains; c. coli, 2 strains; c. fetus subsp. fetus, 2 strains; c. hyointestinalis, 2 strains; and c. upsaliensis, 2 strains) and from 4 helicobacter strains (h. pylori, 2 strains; and h. mustelae, 2 strains) with hindiii, ssti, bamhi, dpni, mboi, and sau3ai. restriction fragments were then separated by electrophoresis in 1% agarose or 10% polyacrylamide gels. only dnas from three campylobacter species (c. jejuni, c. coli, a ... | 1992 | 1459965 |
| character and origin of vacuoles induced in mammalian cells by the cytotoxin of helicobacter pylori. | cytotoxic activity of culture supernates of helicobacter pylori is manifested by vacuolation of mammalian cells in vitro. the formation and maturation of toxin-induced vacuoles in hela cells has been studied to examine the possibility that they are autophagosomal in nature. observation by light microscopy revealed that vacuoles originate in a perinuclear position, increasing in number and size until cell degeneration and lysis occur after 48 h. ultrastructural study of mature vacuoles indicated ... | 1992 | 1460658 |
| [how is stomach ulcer transmitted? epidemiology of helicobacter pylori]. | | 1992 | 1461054 |
| [treatment of stomach ulcer with bismuth subnitrate, oxytetracycline and metronidazole]. | 60 patients with recurrent duodenal ulcers were treated with bismuth subnitrate, oxytetracycline and metronidazole. helicobacter pylori status was assessed before and after treatment by means of the 14c-urea breath test. all patients were helicobacter positive before treatment. four weeks after cessation of therapy h pylori had been eradicated in 57 out of 60 patients (95%). the ulcer healing rate was 100% after six weeks. 43% of the patients complained of moderate to severe side effects, mainly ... | 1992 | 1462293 |
| counting angels and bacteria. the quest for a unifying theory of ulcerogenesis. | | 1992 | 1462950 |
| helicobacter pylori-related gastritis and gastric ulcer. a continuum of progressive epithelial degeneration. | one hundred forty-five consecutive gastric biopsy specimens showing colonization by helicobacter pylori (hp) were studied. biopsy specimens were obtained from patients with the following conditions: gastric ulcer (gu; 76), active chronic gastritis (acg; 52), gu with duodenal ulcer (du; 10), and acg with du (7). the mean age of the patients in the acg group was 8.6 years less than the patients in the gu group. helicobacter pylori colonization and hp-induced epithelial degeneration (ed) were quant ... | 1992 | 1462954 |
| the diagnosis of helicobacter pylori infection in uremic patients. | two urease-based tests--the urease slide test and the radiolabeled urea breath test, are commonly used for the diagnosis of helicobacter pylori infection of the stomach. the reliability of these tests in chronic uremia was compared with serological tests for h pylori antibodies, and with direct detection of the organism by microscopy or culture of gastric antral biopsies. twenty-seven patients with chronic renal failure and dyspepsia underwent upper gastrointestinal endoscopy. twelve of these pa ... | 1992 | 1462985 |
| workshop on gastroduodenal pathology and helicobacter pylori, 28-30 november 1991. | | 1992 | 1463994 |
| [serologic detection of antibodies to helicobacter pylori in children and adolescents using elisa]. | serum antibodies anti-helicobacter pylori (h.p.) which are specific against antigenic determinants of the bacterial body, were determined in 183 non-ulcer dyspeptic children and adolescents, aged 7- to 20 years. 108 patients (59%) of the same group underwent fibroendoscopy for direct detection of h.p. in bioptic specimens of the stomach and duodenum microbiological methods. discrimination analysis revealed a overall positive correlation between the results of the two methods: p < 0.01. for detec ... | 1992 | 1464085 |
| [helicobacter pylori]. | | 1992 | 1464095 |
| eradicating helicobacter pylori in patients with duodenal ulcer. | | 1992 | 1467703 |
| helicobacter (campylobacter) pylori in gastric brushing cytology. | helicobacter (formerly campylobacter) pylori is frequently associated with chronic gastritis and peptic ulcer and has been implicated as an etiologic agent. identification of h. pylori is important for specific treatment with antibiotics and bismuth compounds. we studied 27 patients who presented with symptoms of gastritis or peptic ulcer on whom paired gastric biopsies and gastric brushings for cytology had been performed. biopsies were stained with h & e and warthin-starry or giemsa for h. pyl ... | 1992 | 1468331 |
| results of a multicentre european survey in 1991 of metronidazole resistance in helicobacter pylori. european study group on antibiotic susceptibility of helicobacter pylori. | in 1991 a multicentre survey on the prevalence of metronidazole resistance in helicobacter pylori in vitro was carried out in 12 hospitals in 11 different european countries. the susceptibility of helicobacter pylori to metronidazole was determined in each centre by measuring the mic on agar with the pdm e-test (ab biodisk) according to a standard procedure. overall, 122 of 443 (27.5%) strains tested were resistant to metronidazole (mic > 8 micrograms/ml). the level of resistance to metronidazol ... | 1992 | 1468415 |
| the prevalence of helicobacter pylori serum antibodies in children with recurrent abdominal pain. | as part of a large, prospective study we investigated the prevalence helicobacter pylori serum antibodies in children with recurrent abdominal pain (rap). all patients suffered from recurrent bouts of abdominal pain for at least 6 months and ranged in age from 6 to 12 years. h. pylori antibodies were detected using an enzyme-linked immunosorbent assay. the prevalence of h. pylori antibodies in the rap group was compared to that of a control group which consisted predominantly of pre-operative ch ... | 1992 | 1468451 |
| kinetic properties of helicobacter pylori urease compared with jack bean urease. | the urease proteins of the jack bean (canavalia ensiformis) and helicobacter pylori are similar in molecular mass when separated by non-denaturing gradient polyacrylamide gel electrophoresis, both having three main forms. the molecular mass of their major protein form is within the range 440-480 kda with the other two lesser forms at 230-260 kda and 660-740 kda. these forms are all urease active; however, significant kinetic differences exist between the h. pylori and jack bean ureases. jack bea ... | 1992 | 1468614 |
| modes of helicobacter colonization and gastric epithelial damage. | a total of 144 gastric biopsies colonized by helicobacter-like organisms were studied under light and differential interference contrast microscopy for the modes of bacterial colonization. biopsies were also graded for the degree of epithelial damage (epithelial-damage-grade: 0 to 6, in ascending order of severity) and density of helicobacter-like organism (helicobacter-grade: 0 to 6, in ascending order of bacterial density). three modes of colonization were identified: free-in-mucus, surface-ad ... | 1992 | 1468750 |
| two weeks treatment with amoxicillin/omeprazole for eradication of helicobacter pylori. | in an open study, 62 patients with helicobacter pylori-associated ulcer disease or functional dyspepsia were treated for two weeks with 2 x 20 mg omeprazole preprandially and 4 x 500 mg amoxicillin suspension one hour before meals and at night. 57 patients (active ulcer disease: n = 53, functional dyspepsia: n = 4) completed the study without contravening the protocol. the rate of eradication of the bacteria at least 4 weeks after cessation of study medication was 82.5% (47/57 patients). three p ... | 1992 | 1471383 |
| helicobacter pylori infection in an hiv-positive patient. | | 1992 | 1472348 |
| infectious gastroenteritis in infants and children. glutaraldehyde: a potential health risk for nurses. | | 1992 | 1472560 |
| [modified selective medium for isolation of helicobacter pylori]. | to improve the detection rate of helicobacter pylori, many kinds of media were tried and other antibiotics were incorporated according to the antimicrobial susceptibility patterns of clinical isolates in our hospital. we found that brain heart infusion agar supplemented with 1% isovitalex and 5% sheep blood, containing nalidixic acid 10 micrograms/ml, vancomycin 6 micrograms/ml, amphotericin b 2 micrograms/ml and polymixin b 16 micrograms/ml (bnvp) or colistin 5 micrograms/ml (bnvc) inhibited th ... | 1992 | 1473370 |
| nsaid, ulcers, and prostaglandins. | the pathogenesis of nonsteroidal antiinflammatory drug (nsaid) induced gastrointestinal (gi) injury is complex and includes contributions from direct topical injury and reduced mucosal resistance due to indirect or systemic inhibition of mucosal prostaglandin (pg) synthesis. some nsaid that cause less inhibition of gastroduodenal pg synthesis appear to cause less gi injury. nsaid induced gi complications include adverse symptoms, endoscopically observable mucosal damage, and ulcer complications. ... | 1992 | 1474538 |
| is there a place for antacids in the treatment of helicobacter pylori infection? | two pilot studies were performed to determine whether aluminium-containing antacids may have a place in the treatment of helicobacter pylori infection. the urease activity of h. pylori is cytopathic to gastric epithelium, and inhibition of this enzyme may have therapeutic potential. in the first study 24 subjects, 12 of which were infected with h. pylori, were given 1 tablet of chewable aluminium hydroxide-containing antacids 10 min before a 14c-urea breath test. gastric urease activity was supp ... | 1992 | 1475615 |