| a two-tube multiplex real-time rt-pcr assay for the detection of four hemorrhagic fever viruses: severe fever with thrombocytopenia syndrome virus, hantaan virus, seoul virus, and dengue virus. | the aim of this study was to develop and evaluate a two-tube multiplex real-time rt-pcr assay for the detection and identification of four viral hemorrhagic fever (vhf) pathogens, severe fever with thrombocytopenia syndrome virus (sftsv), hantaan virus (htnv), seoul virus (seov), and dengue virus (denv), from human clinical samples. the two-tube multiplex real-time rt-pcr assay we developed has a sensitivity of 10 copies/μl for each of the targets, and the performance was linear within the range ... | 2013 | 23532380 |
| [human hantavirus diseases - still neglected zoonoses?]. | hantavirus disease is the most common rodent-borne viral infection in the czech republic, with a mean annual incidence of 0.02 cases per 100 000 population and specific antibodies detected in 1% of the human population. four hantaviruses (puumala, dobrava-belgrade, tula, and seewis) circulate in this country, of which puumala virus (responsible for a mild form of hemorrhagic fever with renal syndrome called nephropathia epidemica) and dobrava-belgrade virus (causing haemorrhagic fever with renal ... | 2015 | 26795222 |
| detection of dobrava hantavirus rna in apodemus mice in bulgaria. | several hantaviruses cause hemorrhagic fever with renal syndrome (hfrs) in europe: dobrava-belgrade virus (dobv), puumala, saaremaa, sochi, and seoul virus. although hfrs is endemic in bulgaria, genome sequences of hantaviruses have never been detected in wild rodents. to identify rodent reservoirs, a total of 691 rodents from three endemic regions were trapped in 2011-2012 and screened by taqman rt-pcr for detection of hantaviral genomic rna. partial small (s) and/or large (l)-segment sequences ... | 2015 | 25521059 |
| hantavirus infections. | over the past few decades understanding and recognition of hantavirus infection has greatly improved worldwide, but both the amplitude and the magnitude of hantavirus outbreaks have been increasing. several novel hantaviruses with unknown pathogenic potential have been identified in a variety of insectivore hosts. with the new hosts, new geographical distributions of hantaviruses have also been discovered and several new species were found in africa. hantavirus infection in humans can result in ... | 2015 | 24750436 |
| genetic characterization of seoul hantavirus originated from norway rats (rattus norvegicus) captured in belgium. | hantaviruses (genus hantavirus, family bunyaviridae) cause hemorrhagic fever with renal syndrome (hfrs) in eurasia and hantavirus (cardio)pulmonary syndrome (hcps) in the americas. so far, in europe, four pathogenic hantaviruses have been found, often in co-circulation: puumala virus (puuv), dobrava virus (dobv), saaremaa virus (saav), and seoul virus (seov). of those, only puuv was found in belgium. recently, in our search for hantaviruses in the flanders region of belgium we collected genetic ... | 2012 | 22711359 |
| immunogenicity of a multi-epitope dna vaccine against hantavirus. | hemorrhagic fever with renal syndrome (hfrs) is a severe epidemic disease caused by hantaviruses including hantaan virus (htnv), seoul virus (seov), dobrava virus (dobv) and puumala virus. three of the four hfrs hantaviruses, htnv, seov, and puuv are found in china. currently, there is no effective strategy available to reduce infection risk. in this study, we constructed a multi-epitope chimeric dna vaccine that encodes expressing 25 glycoprotein epitopes from seov, htnv and puuv (designated as ... | 2012 | 22426376 |
| prevalence and characteristics of escherichia coli and salmonella spp. in the feces of wild urban norway and black rats (rattus norvegicus and rattus rattus) from an inner-city neighborhood of vancouver, canada. | although rat feces are widely suspected to be a source of pathogenic bacteria, few investigators have studied fecal pathogens in rats. we investigated the prevalence and characteristics of escherichia coli and salmonella spp. in norway and black rats (rattus norvegicus and rattus rattus, respectively) from an urban neighborhood of vancouver, canada, collected september 2011-august 2012. colon content was cultured for e. coli and salmonella spp. and screened for the seven most-common enteropathog ... | 2015 | 25932669 |
| detection of imjin virus and seoul virus in crocidurine shrews in shandong province, china. | recently, hantaviruses have been discovered in insectivores in europe, asia, africa, and north america. imjin virus (mjnv) was first isolated from the lung tissues of ussuri white-toothed shrew (crocidura lasiura) from south korea in 2009. we aim to detect the species and prevalence of insectivore- and rodent-borne hantaviruses in shrews and rodents. | 2017 | 28287930 |
| type inactivated bivalent hantavirus vaccines using dual fluorescence quantitative real-time pcr: establishment and evaluation. | to establish a dual fluorescence quantitative real-time polymerase chain reaction (dfqrt-pcr) method for typing inactivated bivalent vaccines of hantaan virus (htnv, type i) and seoul virus (seov, type ii) found in china. primers and probes were designed based on s segment of the hantavirus. fam and hex were added to the probes for the type i and type ii vaccines, respectively. the s fragments were cloned into the pmd18-t vector to create pmd18-t/htnv and pmd18-t/seov plasmids, respectively. the ... | 2017 | 27301695 |
| prevalence of hemorrhagic fever with renal syndrome in qingdao city, china, 2010-2014. | hemorrhagic fever with renal syndrome (hfrs) was considered to be transmitted by apodemus agrarius and rattus norvegicus, the principal animal hosts of hantaan virus and seoul virus, respectively. the aim of this study is to determine the correlation of hfrs incidence with capture rate and hantavirus infection rate of rodent species in qingdao city, china. we collected hfrs patients' information and captured field and residential rodents in qingdao city, china from 2010 to 2014. the correlations ... | 2016 | 27786303 |
| development of a sybr-green ⅰ quantitative pcr assay for the detection and genotyping of different hantaviruses. | hemorrhagic fever with renal syndrome (hfrs) is a severe, viral zoonotic disease which occurs worldwide, particularly in asia and europe. in china, the hantaan virus (htnv) and the seoul virus (seov) are known to be the most prevalent causative agents of hfrs. since no protective vaccines or effective treatments are available for human use, accurate and reliable diagnostic methods are essential for disease surveillance. in the present study, the viral loads in cell culture supernatant, infected ... | 2016 | 27430149 |
| genetic characterization of hantaviruses isolated from rodents in the port cities of heilongjiang, china, in 2014. | hantavirus is a tripartite negative-sense rna virus. it can infect humans through contaminated rodent excreta and causes two types of fatal human diseases: hemorrhagic fever with renal syndrome (hfrs) and hantavirus pulmonary syndrome (hps). china exhibits the highest hfrs occurrence rate in the world, and the heilongjiang area is one of the most severely infected regions. | 2016 | 27038799 |
| hemorrhagic fever with renal syndrome, zibo city, china, 2006-2014. | analysis of hemorrhagic fever with renal syndrome cases in zibo city, china, during 2006-2014 showed that it occurred year-round. peaks in spring and fall/winter were caused by hantaan and seoul viruses, respectively. rodent hosts were the striped field mouse for hantaan virus and the brown rat and house mouse for seoul virus. | 2016 | 26812444 |
| development of reverse transcription loop-mediated isothermal amplification assays to detect hantaan virus and seoul virus. | we developed two assays based on one-step reverse transcription loop-mediated isothermal amplification (rt-lamp) to identify hantaan virus (htnv) and seoul virus (seov), members of the hantavirus genus that cause hemorrhagic fever with renal syndrome (hfrs). our results showed that these assays can be conducted within 30min under isothermal conditions. the detection limit for htnv was around 10 copies per reaction, similar to detection levels for quantitative reverse transcription polymerase cha ... | 2015 | 25920565 |
| transmission of haemorrhagic fever with renal syndrome in china and the role of climate factors: a review. | haemorrhagic fever with renal syndrome (hfrs) is a rodent-borne disease that poses a serious public health threat in china. hfrs is caused by hantaviruses, mainly seoul virus in urban areas and hantaan virus in agricultural areas. although preventive measures including vaccination programs and rodent control measures have resulted in a decline in cases in recent years, there has been an increase in incidence in some areas and new endemic areas have emerged. this review summarises the recent lite ... | 2015 | 25704595 |
| influence of hla-drb alleles on haemorrhagic fever with renal syndrome in a chinese han population in hubei province, china. | specific human leucocyte antigen (hla) alleles are considered a genetic risk factor for the progression of haemorrhagic fever with renal syndrome (hfrs) caused by hantaviruses. the aim of this study was to establish whether hla-drb alleles are associated with the severity of hfrs caused by different types of hantaviruses in a chinese han population from hubei province of central china. twenty-two specific hla-drb alleles were analysed by sequence-specific primer-polymerase chain reaction (ssp-pc ... | 2015 | 25169964 |
| epidemic characteristics of hemorrhagic fever with renal syndrome in china, 2006-2012. | hemorrhagic fever with renal syndrome (hfrs) caused by hantaviruses is a serious public health problem in china. the national notifiable disease surveillance system (nndss) was established online by china cdc in 2004 and rodent surveillance sites were adjusted to 40 sites in 22 provinces in 2005. here we analyzed the surveillance data of both human cases and rodents host during 2006-2012 to examine the epidemic trends of hfrs in recent years in china. | 2014 | 25012160 |
| quantification of hantaan virus with a sybr green i-based one-step qrt-pcr assay. | hantaan virus (htnv) is a major zoonotic pathogen that causes hemorrhagic fever with renal syndrome (hfrs) in asia, especially in china. shaanxi province, which is located in northwest of china, is one of the areas in china most severely afflicted with hfrs epidemics annually. this study aims to establish a quantitative rt-pcr (qrt-pcr) assay to detect htnv both in cell culture and clinical serum samples. we established a sybr green i-based one-step qrt-pcr assay that targets the s segment of th ... | 2013 | 24278449 |
| development of a sybr green i based one-step real-time pcr assay for the detection of hantaan virus. | hantaan virus (htnv), which belongs to the genus hantavirus, causes hemorrhagic fever with renal syndrome (hfrs) mainly in china. the diagnosis of hfrs depends on clinical manifestations and serological tests. a sybr green i based one-step real-time pcr assay was established in this study to detect htnv. the htnv standard curves were generated by plotting mean cycle threshold (ct) values versus 10-fold serial dilutions of a previous titrated htnv stock over a wide range of concentrations (1×10(7 ... | 2014 | 24269331 |
| role of nucleocapsid protein of hantaviruses in intracellular traffic of viral glycoproteins. | to understand the role of nucleocapsid protein (np) of hantaviruses in viral assembly, the effect of np on intracellular traffic of viral glycoproteins gn and gc was investigated. double staining of viral and host proteins in hantaan virus (htnv)-infected vero e6 cells showed that gn and gc were localized to cis-golgi, in which virus particles are thought to be formed. when htnv gn and gc were expressed by a plasmid encoding glycoprotein precursor (gpc), which is posttranslationally cleaved into ... | 2013 | 24070985 |
| clinical and molecular epidemiological features of hemorrhagic fever with renal syndrome in korea over a 10-year period. | laboratory diagnosis of hemorrhagic fever with renal syndrome (hfrs), an infectious disease caused by rodent-borne hantaviruses in asia and europe, depends primarily on serological methods. since the advent of such serodiagnostic tests, few reports are available about the clinical and molecular epidemiological features of hfrs. | 2013 | 23871164 |
| spatial analysis of hemorrhagic fever with renal syndrome in zibo city, china, 2009-2012. | hemorrhagic fever with renal syndrome (hfrs) is highly endemic in mainland china, where human cases account for 90% of the total global cases. zibo city is one of the most serious affected areas in shandong province china with the hfrs incidence increasing sharply from 2009 to 2012. however, the hotspots of hfrs in zibo remained unclear. thus, a spatial analysis was conducted with the aim to explore the spatial, spatial-temporal and seasonal patterns of hfrs in zibo from 2009 to 2012, and to pro ... | 2013 | 23840719 |
| epidemiology of hantavirus infection in thousand islands regency of jakarta, indonesia. | hemorrhagic fever with renal syndrome (hfrs) is a rodent-borne zoonotic disease caused by hantavirus infection. many hfrs cases have been reported in east asia and north europe, while the situation in southeast asia remains unclear. in this study, the prevalence of hantavirus infection in rodents and humans in thousand islands regency, which is close to the port of jakarta, one of the largest historic ports in indonesia, was investigated. a total of 170 rodents were captured in 2005, and 27 (15. ... | 2013 | 23503293 |
| [genetic characteristics of hantaviruses carried by microtus maximowixzii in yakeshi of inner mongolia, china]. | to analyze the viral genetic characteristics of hantaviruses carried by microtus maximowixzii in yakeshi of inner mongolia autonomous region and its relationship with hantaan virus (htnv) and seoul virus (seov) viruses as well as to identify the natural host of khabarovsk virus (khav). | 2012 | 22967339 |
| dynamics of hantavirus infections in humans and animals in wuhan city, hubei, china. | hemorrhagic fever with renal syndrome (hfrs) has been a significant public problem since the first cases were reported in 1961 in wuhan city (capital of hubei province of china). epidemiological surveys were carried out to better understand the dynamics of hantavirus infection in humans and animals in wuhan. during 1961-2011, a total of 21,820 hfrs cases were registered in wuhan. the two large epidemics had occurred during 1970-1991. they reached peaks in 1973 and 1983, respectively. there have ... | 2012 | 22910184 |
| cross-species transmission in the speciation of the currently known murinae-associated hantaviruses. | to gain more insight into the phylogeny of dabieshan virus (dbsv), carried by niviventer confucianus and other murinae-associated hantaviruses, genome sequences of novel variants of dbsv were recovered from niviventer rats trapped in the mountainous areas of wenzhou, china. genetic analyses show that all known genetic variants of dbsv, including the ones identified in this study, are distinct from other murinae-associated hantaviruses. dbsv variants show geographic clustering and high intraspeci ... | 2012 | 22855492 |
| hantaviruses in rodents and humans, xi'an, pr china. | xi'an, the capital of shaanxi province, located in north-west china, is one of the major endemic areas for haemorrhagic fever with renal syndrome (hfrs). in this study, the epidemiological data of hfrs in xi'an from 1959 to 2010, especially in the past ten years (2001-2010), were surveyed. the features of hantavirus (hv) host carriers, the molecular characteristics of the hv s gene from hosts and patients, and the genome of the viral isolate were also investigated. data showed that there might b ... | 2012 | 22837422 |
| studies on hantavirus infection in small mammals captured in southern and central highland area of vietnam. | to investigate the distribution of hantaviruses among animals in southern and central highland area of vietnam, a total of 1311 serum samples were obtained from rats and asian house shrews (suncus murinus) captured at 11 locations between 2006 and 2009. a total of 1066 serum samples from rats were examined for igg antibodies against hantaan virus, and there were 30 antibody-positive serum samples from rats that had been captured mainly in a port area and urban area in ho chi minh city (hcmc) (2. ... | 2012 | 22673720 |
| isolation and characterization of hantaviruses in far east russia and etiology of hemorrhagic fever with renal syndrome in the region. | hemorrhagic fever with renal syndrome (hfrs) is a serious public health issue in far east russia. two different hantaviruses were isolated from rodents captured in the khabarovsk region: amur virus (amrv; khekhtsir/ap209/2005 strain from apodemus peninsulae) and hantaan virus (htnv; galkino/aa57/2002 strain from a. agrarius). genetic analysis of the new isolates revealed that the m and l segments were apparently different between amrv and htnv, but s segments of the two viruses were closer. the ... | 2012 | 22403334 |
| hemorrhagic fever with renal syndrome in the new, and hantavirus pulmonary syndrome in the old world: paradi(se)gm lost or regained? | since the first clinical description in 1994 of the so-called "hantavirus pulmonary syndrome" (hps) as a "newly recognized disease", hantavirus infections have always been characterized as presenting in two distinct syndromes, the so-called "hemorrhagic fever with renal syndrome" (hfrs) in the old world, with the kidney as main target organ, in contrast to hps in the new world, with the lung as main target organ. however, european literature mentions already since 1934 a mostly milder local hfrs ... | 2014 | 24440318 |
| [seoul hantavirus infection-associated hemorrhagic fever with renal syndrome in france: a case report]. | rodents are hantavirus hosts. in europe, hantaviruses are responsible for human infections resulting in hemorrhagic fever with renal syndrome. thousands of puumala virus infections are reported annually in europe, whereas human seoul virus infections are rarely detected. | 2016 | 26971198 |
| a survey of rodent-borne pathogens carried by wild rattus spp. in northern vietnam. | to examine the prevalence of human pathogens carried by rats in urban areas in hanoi and hai phong, vietnam, we live-trapped 100 rats in january 2011 and screened them for a panel of bacteria and viruses. antibodies against leptospira interrogans (22·0%), seoul virus (14·0%) and rat hepatitis e virus (23·0%) were detected in rats, but antibodies against yersinia pestis were not detected. antibodies against l. interrogans and seoul virus were found only in adult rats. in contrast, antibodies to r ... | 2013 | 23114204 |
| rapid, whole blood diagnostic test for detecting anti-hantavirus antibody in rats. | hantavirus is a causative agent of rodent-borne viral zoonoses, hemorrhagic fever with renal syndrome (hfrs) and hantavirus pulmonary syndrome. seoul virus (seov) is a causative agent of urban and laboratory rat-associated hfrs worldwide. surveillance of rodents has been done mainly by serological detection of hantavirus-specific antibodies by enzyme linked immunosorbent assay (elisa) and immunofluorescent antibody assay (ifa). an immunochromatographic (icg) test was developed with the n-termina ... | 2013 | 23684845 |
| hantavirus (seoul virus) in pet rats: a zoonotic viral threat. | | 2016 | 26868241 |
| seoul hantavirus in brown rats in the netherlands: implications for physicians--epidemiology, clinical aspects, treatment and diagnostics. | the recent discovery of seoul hantavirus (seov) presence in wild rat populations in the netherlands has direct implications for dutch clinicians and hantavirus diagnostics. seov is amongst the old world hantaviruses which cause haemorrhagic fever and renal syndrome (hfrs) in humans. hfrs is characterised by a classical triad of fever, acute kidney injury and haemorrhage, but can show different signs and symptoms in specific cases. seov is transmitted from infected rats to humans by inhalation of ... | 2015 | 25968286 |
| complete genome sequence of a novel mutation of seoul virus isolated from suncus murinus in the fujian province of china. | suncus murinus has been identified as the host for seoul virus (seov). here, we report the complete genome sequence of seov strain fj372/2013, which was isolated from the lung tissue of suncus murinus in the fujian province of china. a mutation a38c was observed in an open reading fragment of the middle segment. | 2015 | 25838472 |
| molecular and serological evidence for seoul virus in rats (rattus norvegicus) in zhangmu, tibet, china. | we report the detection of a virus, tentatively identified as seoul virus (seov), from a rat (rattus norvegicus) collected in the city of zhangmu, tibet. seov rna was detected in lung tissue by reverse transcription (rt)-pcr, followed by sequencing. serum samples collected from zhangmu were positive for seov-specific antibodies (indirect fluorescent antibody test that used seo antigen). sequencing and phylogenetic analysis of partial l and s sequences together with serology results suggest that ... | 2015 | 25772576 |
| rats (rattus norvegicus and rattus losea) harboring seoul hantavirus in qingyuan, southern china: a survey during 2011-2013. | hemorrhagic fever with renal syndrome (hfrs) is a zoonotic disease, which threatens public health and its incidence has increased sharply up to the present time in southern china. a survey of hfrs including in both the natural hosts and humans conducted in qingyuan, southern china, during 2011-2013 revealed that one, two and seven confirmed cases of hfrs occurred in 2011, 2012 and 2013, respectively. rodent densities ranged 1.73%-12.2% and seoul hantavirus was detected by rt-pcr only in rattus n ... | 2014 | 25417507 |
| comment on jameson et al.: prevalence of antibodies against hantaviruses in serum and saliva of adults living or working on farms in yorkshire, united kingdom. | this british hantavirus igg prevalence study, aimed at 119 asymptomatic farmers in england, and using indirect immunofluorescence assay (ifa) as screening technique, concluded that rat-transmitted seoul virus (seov) might be the main suspect as hantaviral pathogen in the uk. exactly the same conclusion, using the same ifa screening technique, resulted from a 1994 serosurvey in the same country, and in 627 clinical cases plus 100 healthy controls. seov-positive study subjects were also mainly far ... | 2014 | 25256389 |
| old world hantaviruses in rodents in new orleans, louisiana. | seoul virus, an old world hantavirus, is maintained in brown rats and causes a mild form of hemorrhagic fever with renal syndrome (hfrs) in humans. we captured rodents in new orleans, louisiana and tested them for the presence of old world hantaviruses by reverse transcription polymerase chain reaction (rt-pcr) with sequencing, cell culture, and electron microscopy; 6 (3.4%) of 178 rodents captured--all brown rats--were positive for a seoul virus variant previously coined tchoupitoulas virus, wh ... | 2014 | 24639295 |
| detection and genetic characterization of seoul virus from commensal brown rats in france. | hantaviruses are single-stranded rna viruses, which are transmitted to humans primarily via inhalation of aerosolised virus in contaminated rodent urine and faeces. whilst infected reservoir hosts are asymptomatic, human infections can lead to two clinical manifestations, haemorrhagic fever with renal syndrome (hfrs) and hantavirus cardiopulmonary syndrome (hcps), with varying degrees of clinical severity. the incidence of rodent and human cases of seoul virus (seov) in europe has been considere ... | 2014 | 24555484 |
| prevalence of antibodies against hantaviruses in serum and saliva of adults living or working on farms in yorkshire, united kingdom. | hantaviruses are an established cause of haemorrhagic fever with renal syndrome (hfrs) in europe. following a confirmed case of hfrs in the uk, in an individual residing on a farm in north yorkshire and the humber, a tidal estuary on the east coast of northern england, and the subsequent isolation of a seoul hantavirus from rats trapped on the patient's farm, it was considered appropriate to further investigate the public health risk of this virus in the region. of a total 119 individuals tested ... | 2014 | 24504130 |
| seoul virus in rats (rattus norvegicus), hyesan, north korea, 2009-2011. | | 2013 | 24229532 |
| pet rat harbouring seoul hantavirus in sweden, june 2013. | | 2013 | 23870077 |
| severe seoul hantavirus infection in a pregnant woman, france, october 2012. | | 2013 | 23647626 |
| the continued emergence of hantaviruses: isolation of a seoul virus implicated in human disease, united kingdom, october 2012. | following a suspected case of hantavirus in a patientsuffering from acute kidney injury, rodents fromthe patient’s property in yorkshire and the humber,united kingdom (uk) were screened for hantaviruses.hantavirus rna was detected via rt-pcr in two rattusnorvegicus. complete sequencing and phylogeneticanalysis established the virus as a seoul hantavirus,which we have provisionally designated as strainhumber. this is the first hantavirus isolated from wildrodents in the uk and confirms the presen ... | 2013 | 23305714 |
| complete genome sequence of seoul virus isolated from rattus norvegicus in the democratic people's republic of korea. | seoul virus (seov) is responsible for 25% of cases of hemorrhagic fever with renal syndrome in asia. here we report the complete genome of strain dprk08. the sequence information provided here is useful for understanding the molecular character of seov in the democratic people's republic of korea (dprk) and the circulation of seov in east asia. | 2012 | 23166256 |
| [genetic analysis on s segment of hantaviruses in rodent hosts from wuhan area, hubei province]. | to investigate the infection and genotype of hantaviruses in rodents from wuhan area, hubei province. | 2012 | 22967338 |
| seoul virus-infected rat lung endothelial cells and alveolar macrophages differ in their ability to support virus replication and induce regulatory t cell phenotypes. | hantaviruses cause a persistent infection in reservoir hosts that is attributed to the upregulation of regulatory responses and downregulation of proinflammatory responses. to determine whether rat alveolar macrophages (ams) and lung microvascular endothelial cells (lmvecs) support seoul virus (seov) replication and contribute to the induction of an environment that polarizes cd4(+) t cell differentiation toward a regulatory t (treg) cell phenotype, cultured primary rat ams and lmvecs were mock ... | 2012 | 22915818 |
| seoul virus infection in humans, france, 2014-2016. | we report detection of seoul virus in 3 patients in france over a 2-year period. these patients accounted for 4 (1.7%) of 434 hantavirus infections reported during this time. more attention should be given to this virus in europe where surveillance has been focused mostly on puumala and dobrava-belgrade hantaviruses. | 2017 | 28368241 |
| detection and characterization of three zoonotic viruses in wild rodents and shrews from shenzhen city, china. | diverse species of rodents and shrews, which are abundant worldwide, harbor a variety of viruses; some of these are closely related to human viruses and possess zoonotic potential. previously studies have demonstrated that the mammarenavirus and hantavirus carried by rodents or shrews could cause diseases in human population. to determine the distribution of zoonotic viruses in shenzhen city, the major city in southern china with a high population density, we analyzed 225 rodents (rattus norvegi ... | 2017 | 28721632 |
| comparison of serological assays to titrate hantaan and seoul hantavirus-specific antibodies. | hantaan and seoul viruses, in the hantavirus genus, are known to cause hemorrhagic fever with renal syndrome (hfrs). the plaque reduction neutralization test (prnt), as conventional neutralization test for hantaviruses, is laborious and time-consuming. alternatives to prnt for hantaviruses are required. | 2017 | 28720142 |
| phylogenetic analysis based on mitochondrial dna sequences of wild rats, and the relationship with seoul virus infection in hubei, china. | seoul virus (seov), which is predominantly carried by rattus norvegicus, is one of the major causes of hemorrhagic fever with renal syndrome (hfrs) in china. hubei province, located in the central south of china, has experienced some of the most severe epidemics of hfrs. to investigate the mitochondrial dna (mtdna)-based phylogenetics of wild rats in hubei, and the relationship with seov infection, 664 wild rats were captured from five trapping sites in hubei from 2000-2009 and 2014-2015. using ... | 2017 | 28669005 |
| elevated plasma growth arrest-specific 6 protein levels are associated with the severity of disease during hantaan virus infection in humans. | hemorrhagic fever with renal syndrome (hfrs) is caused by hantaan virus (htnv) and seoul virus infection in asia. the clinical manifestation of hfrs is characterized by the rapid loss of renal function (acute kidney injury) and thrombocytopenia. the specific immune mechanisms that cause thrombocytopenia in hfrs are not well described. the growth arrest-specific 6 (gas6) protein and tam (tyro3, axl and mer) receptors have been recently shown to play prominent roles in immune regulation, and high ... | 2017 | 28537534 |
| evidence of infection with leptospira interrogans and spotted fever group rickettsiae among rodents in an urban area of osaka city, japan. | we examined 33 rodents captured in an urban area of osaka city, japan for igg antibodies against seoul virus, severe fever with thrombocytopenia syndrome virus, hepatitis e virus, leptospira interrogans, yersinia pestis, spotted fever, typhus and scrub typhus group rickettsiae. we found that 3 (9.1%) and 1 (3.0%) of the 33 rodents had antibodies against l. interrogans and spotted fever group rickettsiae, respectively. dnas of leptospires were detected from 2 of the 3 seropositive rodents, but dn ... | 2017 | 28529271 |
| complete genome sequence of seoul virus strain tchoupitoulas. | seoul virus (genus hantavirus; family bunyaviridae) is an emerging pathogen associated with cases of acute kidney injury in several countries across the globe. we report here the whole-genome sequence of the tchoupitoulas strain of seoul virus isolated in new orleans, la. | 2016 | 27284149 |
| multiplex pcr-based next-generation sequencing and global diversity of seoul virus in humans and rats. | seoul virus (seov) poses a worldwide public health threat. this virus, which is harbored by rattus norvegicus and r. rattus rats, is the causative agent of hemorrhagic fever with renal syndrome (hfrs) in humans, which has been reported in asia, europe, the americas, and africa. defining seov genome sequences plays a critical role in development of preventive and therapeutic strategies against the unique worldwide hantavirus. we applied multiplex pcr-based next-generation sequencing to obtain seo ... | 2018 | 29350137 |
| pets, purity and pollution: why conventional models of disease transmission do not work for pet rat owners. | in the united kingdom, following the emergence of seoul hantavirus in pet rat owners in 2012, public health authorities tried to communicate the risk of this zoonotic disease, but had limited success. to explore this lack of engagement with health advice, we conducted in-depth, semi-structured interviews with pet rat owners and analysed them using a grounded theory approach. the findings from these interviews suggest that rat owners construct their pets as different from wild rats, and by elevat ... | 2017 | 29215554 |
| notes from the field: multiple cases of seoul virus infection in a household with infected pet rats - tennessee, december 2016-april 2017. | | 2017 | 29023435 |
| high prevalence of seoul hantavirus in a breeding colony of pet rats. | as part of further investigations into three linked haemorrhagic fever with renal syndrome (hfrs) cases in wales and england, 21 rats from a breeding colony in cherwell, and three rats from a household in cheltenham were screened for hantavirus. hantavirus rna was detected in either the lungs and/or kidney of 17/21 (81%) of the cherwell rats tested, higher than previously detected by blood testing alone (7/21, 33%), and in the kidneys of all three cheltenham rats. the partial l gene sequences ob ... | 2017 | 28965516 |
| seoul virus in the brown rat ( rattus norvegicus ) from ürümqi, xinjiang, northwest of china. | hantavirus infections among human populations are linked to the geographic distribution of the host rodents that carry the viruses. to determine the presence and distribution of hantaviruses in the northern region of xinjiang uygur autonomous region (xuar), northwestern china, 844 rodents were captured from five locations in four dissimilar habitats during 2010-14 and examined for hantavirus infection. hantavirus nucleic acids were firstly detected in the brown rat ( rattus norvegicus ) from ürü ... | 2016 | 27258409 |
| identification of a novel hantavirus strain in the root vole (microtus oeconomus) in lithuania, eastern europe. | hantaviruses are zoonotic pathogens that can cause subclinical to lethal infections in humans. in europe, five orthohantaviruses are present in rodents: myodes-associated puumala orthohantavirus (puuv), microtus-associated tula orthohantavirus, traemmersee hantavirus (trav)/ tatenale hantavirus (tatv)/ kielder hantavirus, rat-borne seoul orthohantavirus, and apodemus-associated dobrava-belgrade orthohantavirus (dobv). human puuv and dobv infections were detected previously in lithuania, but the ... | 2020 | 32890767 |
| meteorological factors affect the epidemiology of hemorrhagic fever with renal syndrome via altering the breeding and hantavirus-carrying states of rodents and mites: a 9 years' longitudinal study. | the incidence of hemorrhagic fever with renal syndrome (hfrs) in qingdao, china was three times higher than that of the average national level. here we characterized the epidemiology, ecological determinants and pathogen evolution of hfrs in qingdao during 2007-2015. in this longitudinal study, a total of 1846 hfrs patients and 41 hfrs-related deaths were reported. hfrs in qingdao peaked once a year in the fourth quarter. we built a time series generalized additive model, and found that meteorol ... | 2017 | 29184158 |
| seoul orthohantavirus in wild black rats, senegal, 2012-2013. | hantaviruses cause hemorrhagic fever in humans worldwide. however, few hantavirus surveillance campaigns occur in africa. we detected seoul orthohantavirus in black rats in senegal, although we did not find serologic evidence of this disease in humans. these findings highlight the need for increased surveillance of hantaviruses in this region. | 2020 | 32946728 |
| a seroprevalence study to determine the frequency of hantavirus infection in people exposed to wild and pet fancy rats in england. | recent cases of acute kidney injury due to seoul hantavirus infection from exposure to wild or pet fancy rats suggest this infection is increasing in prevalence in the uk. we conducted a seroprevalence study in england to estimate cumulative exposure in at-risk groups with contact with domesticated and wild rats to assess risk and inform public health advice. from october 2013 to june 2014, 844 individual blood samples were collected. hantavirus seroprevalence amongst the pet fancy rat owner gro ... | 2017 | 28724455 |
| immunological responses to seoul orthohantavirus in experimentally and naturally infected brown rats (rattus norvegicus). | to clarify the mechanism of seoul orthohantavirus (seov) persistence, we compared the humoral and cell-mediated immune responses to seov in experimentally and naturally infected brown rats. rats that were experimentally infected by the intraperitoneal route showed transient immunoglobulin m (igm) production, followed by an increased anti-seov immunoglobulin g (igg) antibody response and maturation of igg avidity. the level of seov-specific cytotoxic t lymphocytes (ctls) peaked at 6 days after in ... | 2021 | 33921493 |
| wild rats, laboratory rats, pet rats: global seoul hantavirus disease revisited. | recent reports from europe and the usa described seoul orthohantavirus infection in pet rats and their breeders/owners, suggesting the potential emergence of a "new" public health problem. wild and laboratory rat-induced seoul infections have, however, been described since the early eighties, due to the omnipresence of the rodent reservoir, the brown rat rattus norvegicus. recent studies showed no fundamental differences between the pathogenicity and phylogeny of pet rat-induced seoul orthohanta ... | 2019 | 31319534 |
| serological evidence of thailand orthohantavirus or antigenically related virus infection among rodents in a chronic kidney disease of unknown etiology endemic area, girandurukotte, sri lanka. | we have reported high seroprevalence to thailand orthohantavirus (thaiv) or thaiv-related orthohantavirus (trhv) among patients with chronic kidney disease of unknown etiology in girandurukotte, sri lanka. thaiv or trhv infection is considered to be transmitted by rodent hosts in this area, but its reservoir rodents have not yet been identified. hence, 116 rodents were captured, and seroprevalences were examined by indirect immunofluorescent antibody assay (immunofluorescence assay [ifa]) using ... | 2019 | 31339833 |
| seroprevalence of hantaviruses and leptospira in muskrat and coypu trappers in the netherlands, 2016. | aims: seoul orthohantavirus (seov) and leptospira spp. are zoonotic pathogens with rats as main reservoir. recently, the presence of seov in brown rats was reported in one region in the netherlands. brown rats are a frequent bycatch in traps placed to catch muskrats (ondatra zibethicus) and coypus (myocastor coypus), and thus are a potential health risk for trappers. it was our aim to determine the seroprevalence of orthohantavirus, specifically seov, and leptospira spp in dutch trappers. method ... | 2018 | 29805784 |