| study of hepatitis b (hb) vaccine non-responsiveness among health care workers from an endemic area (taiwan). | to evaluate the etiology of non-responsiveness to hepatitis b (hb) vaccination in adults from an endemic area. | 2005 | 16343067 |
| pediatric fulminant hepatic failure in endemic areas of hepatitis b infection: 15 years after universal hepatitis b vaccination. | to investigate the role of hepatitis b virus (hbv) infection in pediatric fulminant hepatic failure (fhf) after the launch of universal hbv vaccination, the authors analyzed the data from patients with fhf collected from a nationwide collaborative study group. children aged 1 month to 15 years who were diagnosed with fhf (62 males and 33 females) between 1985-1999 were included. hbv infection (hepatitis b surface antigen [hbsag] and/or immunoglobulin m hepatitis b core antibody [igm anti-hbc] se ... | 2004 | 14752823 |
| a population-based study investigating the association between metabolic syndrome and hepatitis b/c infection (keelung community-based integrated screening study no. 10). | we aimed to assess the association between metabolic syndrome (ms) and hepatitis b/c virus infection using a large population-based study. | 2006 | 16404404 |
| precore/core promoter mutations and genotypes of hepatitis b virus in chronic hepatitis b patients with fulminant or subfulminant hepatitis. | the association of precore stop codon mutation (a1896), dinucleotide mutation (t1762/a1764) in the basic core promoter of hepatitis b virus (hbv) genome, and genotype of hbv with fulminant or subfulminant hepatitis remains controversial. we studied hbv genotypes as well as mutations in the precore and basic core promoter regions in 18 hepatitis b carriers with fulminant or subfulminant hepatitis. genotyping of hbv was performed by polymerase chain reaction-restriction fragment length polymorphis ... | 2004 | 14981756 |
| hepatitis b virus transmission and hepatocarcinogenesis: a 9 year retrospective cohort of 13676 relatives with hepatocellular carcinoma. | familial clustering of hepatitis b virus (hbv) infection is related to perinatal transmission, and is the main cause of familial-type hepatocellular carcinoma (hcc). the route of hbv transmission differs between the children and siblings of patients with hcc. this study examined the differences in hbv carrier rates and hcc-related mortality between two generations in hcc families. | 2004 | 15030982 |
| genotypic dominance and novel recombinations in hbv genotype b and c co-infected intravenous drug users. | pathogenic differences among hepatitis b virus (hbv) genotypes have been documented. however, the interaction between different hbv genotypes remains unclear. herein, we chose hbv genotypes b (hbv/b) and c (hbv/c) co-infected intravenous drug users to study this issue. hbv genotype was determined in 40 hbsag, anti-hcv, and anti-hdv co-positive intravenous drug users by using genotype-specific primers. the distribution of hbv genotype was as follows: hbv genotype b alone in 29 (72.5%); hbv genoty ... | 2004 | 15042642 |
| biotransformation of imperatorin by aspergillus flavus. | imperatorin (1) was metabolized by aspergillus flavus, in growth media, to give five metabolites. on the basis of their physical data, the structures of the five metabolites were elucidated as xanthotoxol (2), e-trichoclin (3), z-trichoclin (4), e-imperatorin acid (5), and z-imperatorin acid (6); among these, 4, 5, and 6 were characterized as new coumarins. the five metabolites 2-6 were tested for anti-hepatitis b virus activity in vitro and found to be less active than the parent compound 1. | 2004 | 15217285 |
| phylogenetic analysis of influenza b virus in taiwan, 1997 to 2001. | seventeen strains of influenza b virus were isolated and identified from 1997 to 2001. throat swabs were collected in children who presented in medical centers in both central and northern parts of taiwan. to clarify the molecular characteristics of these isolates, both partial hemagglutinin (ha) gene and nonstructural (ns) gene nucleotide sequences were cloned and subjected to nucleotide sequence analysis. the phylogenetic analysis of the ha gene revealed that 16 out of 17 strains were similar ... | 2004 | 15221032 |
| survey of hepatitis b surface variant infection in children 15 years after a nationwide vaccination programme in taiwan. | it is not known whether hepatitis b virus (hbv) with mutations in the a determinant (amino acids (aa) 121-149) of the hepatitis b surface antigen (hbsag) affect vaccination efficacy. | 2004 | 15361503 |
| hla typing associated with hepatitis b e antigen seroconversion in children with chronic hepatitis b virus infection: a long-term prospective sibling cohort study in taiwan. | to conduct a prospective cohort study to clarify the relationship between human leukocyte antigen (hla) polymorphisms and the seroconversion of hepatitis b e antigen (hbeag). | 2006 | 16737879 |
| screening for viral hepatitis among male non-drug-abuse prisoners. | to describe the prevalence of hepatitis b virus (hbv) and hepatitis c virus (hcv) infection and the associated risk factors in a prison population. | 2006 | 16803696 |
| a survey on the prevalence and management of hepatitis b after renal transplantation in asian-pacific countries. | the carrier rate for hepatitis b virus (hbv) varies from 1% to 2% to 10% in asian-pacific countries. a survey involving 12 transplant centers from 11 countries in this region showed that 1% to 25% of kidney transplant recipients were infected with hbv, and up to 60% of these subjects showed abnormal liver biochemistry. while nearly all centers tested anti-hbs in potential kidney transplant recipients, hbv vaccination of nonimmune subjects was routine in only 66.7%. one-third of the surveyed unit ... | 2004 | 15518771 |
| viral hepatitis and proteinuria in an area endemic for hepatitis b and c infections: another chain of link? | virus hepatitis may lead to nephropathy as one of its multiple extrahepatic manifestations. proteinuria by dipstick, a simple test in practice, is a useful and cardinal sign of underlying renal abnormalities. the aim of this study was to elucidate the impact of hepatitis b virus (hbv) and/or hepatitis c virus (hcv) infections on the occurrence of proteinuria amongst adults. | 2006 | 16918823 |
| cost of chronic hepatitis b virus infection in taiwan. | to estimate the direct medical costs involved in the treatment of chronic hepatitis b (chb) patients in taiwan from a public resource perspective. | 2004 | 15602163 |
| comparing dental students' knowledge of and attitudes toward hepatitis b virus-, hepatitis c virus-, and hiv-infected patients in taiwan. | this study investigated and compared taiwanese dental students' knowledge of hepatitis b virus (hbv), hepatitis c virus (hcv), and hiv infection, attitudes toward infected patients, and important factors associated with the willingness to treat infected patients. in 2001, a self-administered questionnaire survey was conducted on all 1930 dental students enrolled from seven dental schools in taiwan, with a response rate of 54.4%. multiple logistic regression analysis was applied to assess the rel ... | 2004 | 15630786 |
| hepatitis b virus genotype and dna level and hepatocellular carcinoma: a prospective study in men. | although chronic infection with hepatitis b virus (hbv) has been established as a cause of hepatocellular carcinoma (hcc), the roles of viral load and hbv genotype remain unclear. | 2005 | 15713961 |
| hepatitis b virus seropositivity is not associated with increased risk of carotid atherosclerosis in taiwanese. | chronic infection has been proposed to increase the risk of atherosclerosis in several experimental and epidemiological studies. however, the relationship of chronic hepatitis b virus (hbv) infection and atherosclerosis remains controversial. we conducted this cross-sectional study to evaluate the association of carotid atherosclerosis with hepatitis b seropositivity. | 2007 | 17134707 |
| development of hepatocellular carcinoma after successful management of esophageal variceal bleeding. | endoscopic and pharmacological treatments significantly reduce recurrent esophageal variceal bleeding and improve the prognosis of cirrhotic patients. this study was aimed to evaluate the incidence, risk factors, treatment and prognosis of hepatocellular carcinoma after esophageal variceal bleeding. | 2004 | 15720069 |
| basal core-promoter mutant of hepatitis b virus and progression of liver disease in hepatitis b e antigen-negative chronic hepatitis b. | the long-term outcomes in hepatitis b e antigen (hbeag)-negative chronic hepatitis b are distinct from those in hbeag-positive chronic hepatitis. however, the molecular virological factors that contribute to the progression of liver disease in this special clinical setting remain largely unknown. we thus investigated the association of hepatitis b virus (hbv) genotypes as well as precore/basal core-promoter mutations with the clinical and virological characteristics of patients with hbeag-negati ... | 2005 | 15910494 |
| determinants of early mortality and benefits of lamivudine therapy in patients with hepatitis b virus-related decompensated liver cirrhosis. | chronic hepatitis b infection (hbv) is a major health problem worldwide. the prognosis is grave for patients with hbv-related decompensated liver cirrhosis (lc). we evaluated the effectiveness and the determinants of early mortality of lamivudine treatment in patients with hbv-related decompensated lc. thirty patients with hbv-related decompensated lc and active viral replication were treated with lamivudine 100 mg daily for a median duration of 9 months. among these patients, five patients died ... | 2005 | 15985009 |
| clinical significance of hepatitis b virus (hbv) genotypes and precore and core promoter mutations affecting hbv e antigen expression in taiwan. | to assess the prevalence and clinical significance of hepatitis b virus (hbv) genotypes and precore and core promoter mutations in taiwan, a cohort of 200 taiwanese chronic hepatitis b patients was analyzed. the hbv genotypes and sequences of the precore and the core promoter regions were determined in 66 asymptomatic carriers and 134 patients who had liver biopsy-verified chronic hepatitis and liver cirrhosis. the hbv e-antigen (hbeag)-negative patients had a higher frequency of mutations at co ... | 2005 | 16333089 |
| infectious complications after heart transplantation in chinese recipients. | several factors appear to influence the incidence and type of infectious complications among different populations of transplant recipients. this study sought to assess the incidence and type of infection after transplantation in chinese heart allograft recipients. a total of 130 infectious episodes occurred in 192 consecutive heart transplantation patients between june 1993 and may 2004. the median length of follow-up was 46.7+/-38.4 months. the 1-, 5- and 10-year survival rates were 81.8+/-2.8 ... | 2005 | 15996253 |
| risk of hepatocellular carcinoma across a biological gradient of serum hepatitis b virus dna level. | serum hepatitis b virus (hbv) dna level is a marker of viral replication and efficacy of antiviral treatment in individuals with chronic hepatitis b. | 2006 | 16391218 |
| udp-glucuronosyltransferase 1a7 genetic polymorphisms are associated with hepatocellular carcinoma risk and onset age. | it has been demonstrated that the udp-glucuronosyltransferase (ugt) 1a7*3 allele is a risk factor for hepatocellular carcinoma (hcc) in german and japanese populations. in this study, therefore, we evaluated the association between ugt1a7 genetic polymorphisms and hcc risk in southern taiwan, where hepatitis b virus (hbv) and hepatitis c virus (hcv) infections are endemic. | 2005 | 16086712 |
| correlation of interleukin-10 gene haplotype with hepatocellular carcinoma in taiwan. | polymorphisms in cytokine genes can influence immune responses, inflammation and tissue injury, and may affect the outcome of hepatitis b virus (hbv) infection. we analyzed single nucleotide polymorphisms (snp) in the interleukin (il)-10 gene among 344 hbv carriers and 208 patients with hepatocellular carcinoma (hcc). genotypes and haplotypes were tested for association with hcc. il-10/-592 c/c genotype was associated with a higher risk for hcc compared with il-10/-592 a/c and a/a genotypes [odd ... | 2006 | 16441483 |
| prevalence of human immunodeficiency virus and sexually transmitted infections and risky sexual behaviors among men visiting gay bathhouses in taiwan. | this study aimed to investigate the prevalence of human immunodeficiency virus (hiv) and sexually transmitted infections (stis) and predictors of risky sexual behaviors among men visiting gay bathhouses. | 2006 | 16543861 |
| two decades of universal hepatitis b vaccination in taiwan: impact and implication for future strategies. | following the world's first successful implementation of a universal hepatitis b virus (hbv) vaccination program for infants in taiwan 20 years ago, we performed this study to evaluate the long-term protection afforded by hbv vaccination and to rationalize further prevention strategies. | 2007 | 17433322 |
| geographic and ethnic variations of long-term efficacy and immunogenicity of hepatitis b vaccination in hualien, a hbv hyperendemic area. | it is uncertain whether immunologic memory persists for 15 years or more after immunization and whether the efficacy of universal hepatitis b vaccination program (uhbvp) in socio-economically disadvantaged area with hyperendemicity of hepatitis b virus (hbv) infection is similar. we assayed hepatitis b surface antigen (hbsag) and antibody to hbsag (anti-hbs) on 2839 students aged 15 years or more born before (n = 248) and after (n = 2591) uhbvp. we found that students born after uhbvp had signif ... | 2006 | 16574284 |
| genotypes and viremia of hepatitis b and d viruses are associated with outcomes of chronic hepatitis d patients. | genotypes and viremia of hepatitis d virus (hdv) and hepatitis b virus (hbv) may be associated with outcomes. this study evaluated the impact of viral genotypes and viremia on outcomes of dual hbv and hdv infection. | 2006 | 16697726 |
| secular trends and geographic variations of hepatitis b virus and hepatitis c virus-associated hepatocellular carcinoma in taiwan. | etiological variations in hepatocellular carcinoma (hcc) exist across different geographic areas. to gain better control of hcc, we retrospectively studied the secular trends and geographic variations in hepatitis b virus (hbv)-related and hepatitis c virus (hcv)-related hccs in taiwan. a total of 18,423 hcc cases enrolled in 8 medical centers from 1981 to 2001 were reviewed. overall, 67% of male hcc in taiwan was related to hbv infection whereas 55.2% of female hcc in taiwan was related to hcv ... | 2006 | 16708389 |
| type 2 diabetes and hepatocellular carcinoma: a cohort study in high prevalence area of hepatitis virus infection. | this study aimed to elucidate the relationship of type 2 diabetes, other known risk factors, and primary hepatocellular carcinoma (hcc) in countries with a high prevalence of hepatitis infection. we followed a prospective cohort of 54,979 subjects who participated in the keelung community-based integrated screening program between 1999 and 2002. a total of 5,732 subjects with type 2 diabetes cases were identified at enrollment on the basis of fasting blood glucose level, and a total of 138 confi ... | 2006 | 16729295 |
| increasing appearance of reassortant influenza b virus in taiwan from 2002 to 2005. | genetic and antigenic analyses of influenza b virus field strains isolated in taiwan from 1998 to 2005 were performed. to investigate the molecular evolution of influenza b viruses, sequence analysis of the hemagglutinin (ha1 subunit) and neuraminidase genes was performed. all influenza b viruses isolated between 1998 and 2000 belonged to the b/yamagata/16/88 lineage. the b/victoria/2/87 lineage, which was cocirculating with the yamagata lineage, was identified in taiwan in march 2001. concurren ... | 2006 | 16891481 |
| long-term trends and geographic variations in the survival of patients with hepatocellular carcinoma: analysis of 11,312 patients in taiwan. | the survival rates of patients with hepatocellular carcinoma (hcc) were investigated over the past 20 years to clarify the long-term survival trend. | 2006 | 16928217 |
| thrombocytopenia as a surrogate for cirrhosis and a marker for the identification of patients at high-risk for hepatocellular carcinoma. | the objective of this study was to examine the usefulness of platelet counts in the diagnosis of cirrhosis and for identifying high-risk individuals in a community-based hepatocellular carcinoma (hcc) screening program. | 2006 | 17019738 |
| risk and predictors of mortality associated with chronic hepatitis b infection. | the study objective was to determine the risk of all-cause and cause-specific mortality as well as to examine the predictors of mortality in chronic hepatitis b infection. | 2007 | 17678844 |
| sequence analysis of a duck picornavirus isolate indicates that it together with porcine enterovirus type 8 and simian picornavirus type 2 should be assigned to a new picornavirus genus. | in a 1990 outbreak, a virus isolated in taiwan from the intestines of ducks showing signs of hepatitis was tentatively classified as a picornavirus on the basis of physical, chemical, and morphological characteristics. the virus was cloned and then found not to be type 1 duck hepatitis virus (dhv-1) or a new serotype of duck hepatitis virus (n-dhv) by serum neutralization. complete genome sequencing indicated that the virus genome had 8351 nucleotides and the typical picornavirus genome organiza ... | 2007 | 17686542 |
| urinary 8-oxodeoxyguanosine, aflatoxin b1 exposure and hepatitis b virus infection and hepatocellular carcinoma in taiwan. | to evaluate the role of oxidative stress and aflatoxin exposure on risk of hepatocellular carcinoma (hcc), a case-control study nested within a community-based cohort was conducted in taiwan. baseline urine samples, collected from a total of 74 hcc cases and 290 matched controls, were used to determine by enzyme-linked immunosorbent assays the level of urinary excretion of 8-oxodeoxyguanosine (8-oxodg), a biomarker of oxidative dna damage and urinary aflatoxin b(1) metabolites, a biomarker of af ... | 2007 | 17127712 |
| prevalence and etiology of elevated serum alanine aminotransferase level in an adult population in taiwan. | the prevalence and etiologies of elevated alanine aminotransferase (alt) have geographic variations and they are rarely reported in taiwan. through a population-based screening study, the prevalence and etiologies of elevated alt in an adult population of taiwan were assessed. | 2007 | 17716352 |
| seroprevalence of hepatitis-b infection amongst taiwanese university students 18 years following the commencement of a national hepatitis-b vaccination program. | in taiwan, the nation-wide hepatitis-b virus (hb) vaccination program was first launched in july 1984 and was directed to those infants born to hepatitis b surface antigen (hbsag) carrier mothers in taiwan. from july 1986 onwards, all infants born in taiwan were immunized against hb. this study examined the hb-infection status amongst students at a taiwanese university 18 years subsequent to the implementation of universal hb vaccination. a total of 1,969 new university entrants in 2005 were gro ... | 2007 | 17177303 |
| influenza in taiwan: seasonality and vaccine strain match. | this article explores seasonality, epidemiology and dominant epidemic strains of influenza in taiwan. surveillance in taiwan demonstrates that influenza is a disease which occurs throughout the year but has peak activity in winter. due to the high mutability of influenza virus, effective vaccination is the best strategy for protection. although the world health organization-recommended vaccine compositions usually matched with around 77% of circulating strains worldwide, the rate of matching in ... | 2005 | 16118670 |
| subgenotypes of hepatitis b virus genotype c in taiwan. | | 2005 | 16136480 |
| mortality in adult patients with epilepsy in taiwan. | to investigate mortality in adult patients with epilepsy in taiwan, a total of 263 patients with epilepsy aged > or = 17 years, referred to the outpatient epilepsy clinic between 1 jan and 31 december 1991, were prospectively enrolled and followed up until 31 december 2000. a total of 32 deaths were reported. overall case-fatality rate was 12.2%. the age-adjusted standard mortality ratio (smr) was calculated to compare the risk of death in patients with epilepsy to the general population. patien ... | 2005 | 16162430 |
| viral etiology of hepatocellular carcinoma and hcv genotypes in taiwan. | etiologic variations of hepatocellular carcinoma (hcc) exist in different geographic areas of the world. hepatitis b virus infection is associated with hcc. however, hepatitis c virus (hcv) infection plays an increasingly more important role in the development of hcc and is associated with more than 30% of hcc in taiwan. the prevalence of hcv infection and hcv genotypes vary in different geographic areas. the prevalence of hcv genotype 1b (hcv-1b) was around 50-70% in taiwan and even varied in d ... | 2006 | 16166793 |
| comparison of recurrence after hepatic resection in patients with hepatitis b vs. hepatitis c-related small hepatocellular carcinoma in hepatitis b virus endemic area. | hepatitis b virus (hbv) and hepatitis c virus (hcv) infection are two important factors in the development of hepatocellular carcinoma (hcc). the carcinogenic mechanism of hbv and hcv is considered to be different. it is interesting to compare the recurrence after hepatic resection in patients with small hcc who were infected with hbv or hcv. | 2005 | 15780044 |
| transmission of occult hepatitis b virus by transfusion to adult and pediatric recipients in taiwan. | the infectivity of occult hepatitis b virus (hbv), defined as hbsag-negative but hbv dna-positive, after transfusion has been low but not negligible. to address this, we investigated the incidence of post-transfusion hbv infection after receiving screened blood units in taiwan. | 2006 | 16168517 |
| prevention of hepatocellular carcinoma by universal vaccination against hepatitis b virus: the effect and problems. | in spite of the success of hepatitis b immunization, still a significant proportion of childhood hepatocellular carcinoma (hcc) failed to be prevented by the hepatitis b immunization program. this study is aimed to investigate the problems in the hcc prevention in children. | 2005 | 16278421 |
| polycyclic aromatic hydrocarbon- and aflatoxin-albumin adducts, hepatitis b virus infection and hepatocellular carcinoma in taiwan. | to determine the association between polycyclic aromatic hydrocarbon (pah) exposure and risk of hepatocellular carcinoma, a case-control study nested within a community-based cohort was conducted in taiwan. baseline blood samples, collected from a total of 174 hcc cases and 776 matched controls, were used to determine the level of pah-albumin adducts by competitive enzyme-linked immunosorbent assay. conditional logistic regression analysis was used to calculate odds ratios (or) and 95% confidenc ... | 2007 | 17250958 |
| prevalence and determinants of senv viremia among adolescents in an endemic area of chronic liver diseases. | senv is a potential causative agent responsible for chronic liver diseases (clds) that are precipitated in early life. senv prevalence in adolescents is unknown and its transmission route is uncertain. | 2007 | 17295867 |
| early mortality in taiwanese lamivudine-treated patients with chronic hepatitis b-related decompensation: evaluation of the model for end-stage liver disease and index scoring systems as prognostic predictors. | both model for end-stage liver disease (meld) and index scores have been used to predict mortality in patients with end-stage liver disease and cirrhosis in western countries. | 2006 | 17296464 |
| short-term lamivudine therapy in hbeag-negative chronic active hepatitis b in taiwan. | lamivudine treatment in hepatitis b e antigen (hbeag)-negative and hepatitis b virus (hbv) dna-positive chronic hepatitis b (chb) patients is associated with poor sustained response. a previous study has shown that short-term lamivudine therapy in hbeag-positive patients with alanine aminotransferase (alt) > 5x upper limit of normal (uln) could achieve a high hbeag response rate and low lamivudine resistance rate. we, therefore, prospectively treated 85 hbeag-negative chb patients with alt > 5x ... | 2006 | 17302259 |
| multiple genotypes of influenza b viruses cocirculated in taiwan in 2004 and 2005. | an influenza b outbreak occurred in taiwan in 2004 and 2005, during which both victoria (vic) and yamagata (ya) lineages cocirculated. this study examined 36 influenza b viral genomes isolated during the outbreak to reveal their reassortment patterns. according to the isolate groupings in phylogenetic analysis, we were able to categorize those 36 isolates as being of either the victoria or yamagata lineage for all eight influenza b virus genomic segments, except for the ns gene, in which clades ... | 2007 | 17329451 |
| forecasting the declining rate of chronic hepatitis-b carrier status at a taiwanese university: twenty years after implementation of an universal hbv vaccination program in taiwan. | prior to the introduction of universal hepatitis b virus (hbv) vaccination in taiwan in 1984, 15-20% of the general population were chronic hbv carriers. | 2007 | 18350735 |
| estimation of seroprevalence of hepatitis b virus and hepatitis c virus in taiwan from a large-scale survey of free hepatitis screening participants. | taiwan is a hyperendemic area of liver diseases. hepatitis b virus (hbv) and hepatitis c virus (hcv) are the two major etiologies of liver diseases in taiwan. this study investigated the seroprevalence of hbv and hcv in taiwan. | 2007 | 17339159 |
| a pilot study for screening blood donors in taiwan by nucleic acid amplification technology: detecting occult hepatitis b virus infections and closing the serologic window period for hepatitis c virus. | blood donors in taiwan currently are screened for hepatitis b virus (hbv), hepatitis c virus (hcv), and human immunodeficiency virus (hiv) infection by immunoassay. the risk of enzyme immunoassay (eia)-negative, nucleic acid amplification technology (nat)-reactive donations is not well understood. this study aimed to screen for such donors in taiwan by a multiplex test (cobas taqscreen, roche) on a commercially available nat system (cobas s 201 system, roche). | 2008 | 18422856 |
| viral hepatitis among male amphetamine-inhaling abusers. | few studies have focused on the clandestinely consumed amphetamine as a primary drug. the purpose of this study was to estimate the prevalence of hepatitis b virus (hbv) and hepatitis c virus (hcv) infection and the related factors in male amphetamine-inhaling abusers. | 2007 | 17445007 |
| sonographic fatty liver and hepatitis b virus carrier status: synergistic effect on liver damage in taiwanese adults. | to examine the epidemiology of hepatitis b virus carrier status (hbvc) and sonographic fatty liver (sfl) in taiwanese adults, and to evaluate their possible interaction in inducing liver damage (ld). >from an epidemiological viewpoint, we analyzed previous studies which indicated that fatty liver sensitizes host immune response to hbv infection and enhances liver damage. | 2007 | 17465470 |
| metabolic factors and risk of hepatocellular carcinoma by chronic hepatitis b/c infection: a follow-up study in taiwan. | this study investigated whether obesity, diabetes, and other metabolic factors are independently associated with hepatocellular carcinoma (hcc), stratified by hepatitis b virus (hbv) and hepatitis c virus (hcv) serostatus, and explored the possible joint influence of obesity/diabetes and hbv/hcv infections on the risk of hcc. | 2008 | 18505690 |
| seroprevalence of viral hepatitis and infectious complications among human immunodeficiency virus-infected injection drug users at a referral hospital. | the seroprevalence of viral hepatitis and spectrum of infectious complications among human immunodeficiency virus (hiv)-infected injection drug users (idus) remains unclear in taiwan, although there has been a significant increase in the prevalence of hiv infection among idus in the last 2 to 3 years. | 2008 | 18629414 |
| hepatitis c virus infection and the development of type 2 diabetes in a community-based longitudinal study. | the temporal relation of hepatitis c virus (hcv) infection to the development of type 2 diabetes remains unknown. the authors followed 4,958 persons aged > or =40 years without diabetes (3,486 seronegative, 812 anti-hcv+, 116 with hepatitis b virus/hcv coinfection, and 544 hepatitis b surface antigen (hbsag)+) from a community-wide cohort in southern taiwan for 7 years (1997-2003) to study the risk of diabetes associated with hcv infection. a total of 474 participants developed diabetes. the 7-y ... | 2007 | 17496314 |
| the oncogenic potential of hepatitis b virus rta181t/ surface truncation mutant. | previously, a less prevalent lamivudine-resistant mutant (rta181t) was discovered in taiwanese patients, in which a stop codon in the surface gene concomitantly occurred, leading to impaired secretion of hepatitis b virus (hbv) surface antigen. the rta181t mutant also conferred drug resistance to adefovir. we discovered a 39-year-old patient with advanced hepatocellular carcionoma, who was seropositive for hbv e antigen but seronegative for hbv surface antigen. nucleotide sequence analysis revea ... | 2008 | 19043921 |
| increased risk of viral hepatitis in taiwanese male conscriptees with tattoos. | a number of previous literature reviews and research studies have found a correlation between viral hepatitis infections and tattoos. the 1897 subjects of the current study were young adult male military recruits in southern taiwan (476 with tattoos and 1421 without tattoos) who underwent induction physical examinations before conscription. during the examination, blood samples were collected to screen for hepatitis b surface antigen, antibodies to hepatitis c virus (anti-hepatitis b hcv), syphi ... | 2007 | 17521106 |
| gender difference in the clinical and behavioral characteristics of human immunodeficiency virus-infected injection drug users in taiwan. | injection drug users (idus) have become the major contributors to the human immunodeficiency virus (hiv)/acquired immunodeficiency syndrome epidemic in taiwan, accounting for more than 60% of new cases in 2005. in taiwan, gender difference in risk factors for hiv among idus has not been reported before. we studied the clinical and sociodemographic characteristics, sexual behaviors, drug use histories and criminal records of male and female hiv-infected idus. | 2007 | 17588840 |
| hbv serological markers of vaccinated children in remote areas of taiwan: emphasis on factors contributing to vaccine failure. | a serosurvey targeting hepatitis b virus (hbv)-vaccinated children born between 1986 and 1998 was conducted in 2001 in remote taiwanese villages where a 1993 serosurvey indicated high vaccine failure. the hbv s antigen (hbsag) seropositive rate among vaccinees of 3-6-year-old children in 2001 was significantly lower than that of 1993 and was higher among children who had a delayed vaccination schedule and received the plasma-derived vaccine. vaccine escape variants were more prevalent among reci ... | 2007 | 17629600 |
| epidemiology of hepatitis b virus infection among young adults in taiwan, china after public vaccination program. | the public vaccination program of hepatitis b virus (hbv) was launched during 1984 in taiwan, china. however, the long-lasting protective efficacy of hbv vaccination among adolescents older than 15 years of age was seldom recorded. | 2007 | 17637244 |
| subgenotypes of hepatitis b virus genotype c do not correlate with disease progression of chronic hepatitis b in taiwan. | hepatitis b virus (hbv) genotype c (hbv/c) has two subgenotypes: hbv/cs and ce. the prevalence and clinical implications of subgenotype cs and ce in taiwanese hbv carriers remain unknown. | 2007 | 17696938 |
| prevalence of and risk factors for gallbladder polyps detected by ultrasonography among healthy chinese: analysis of 34 669 cases. | gallbladder (gb) polyps are tumor or tumor-like projections arising from gb mucosa. although most polyps are benign, some early gb carcinomas present as polypoid lesions. the diagnosis of gb polyps is relatively easy by ultrasonography. although numerous studies have investigated gb polyps, few studies have addressed the prevalence of and factors associated with gb polyps for specific ethnic populations. this study analyzes the prevalence and factors associated with gb polyps in a chinese popula ... | 2008 | 17725602 |
| high prevalence of occult hepatitis b virus infection in taiwanese intravenous drug users. | the epidemiology and impact of occult hbv infection in intravenous drug users remain largely unknown. the aim of the study was to investigate the prevalence of occult hbv infection among intravenous drug users in taiwan. molecular assays were used to determine the level of serum hbv dna and the genotype in 304 intravenous drug users negative for both hbsag and anti-hcv. of 304 intravenous drug users, 125 (41.1%) were positive for serum hbv dna. the genotype distribution of hbv was as follows: b, ... | 2007 | 17854041 |
| excess mortality of hepatocellular carcinoma and morbidity of liver cirrhosis and hepatitis in hcv-endemic areas in an hbv-endemic country: geographic variations among 502 villages in southern taiwan. | the aim of this study was to investigate excess mortality for hepatocellular carcinoma (hcc) and prevalence of hepatitis and liver cirrhosis (lc) in hepatitis c virus (hcv)-endemic areas in taiwan, which is a hepatitis b virus (hbv)-endemic country. | 2007 | 17201888 |
| a prospective study of hepatitis during antituberculous treatment in taiwanese patients and a review of the literature. | the present study prospectively investigated the incidence of and factors associated with hepatitis during antituberculous treatment in patients with tuberculosis and various underlying diseases. the results were compared with those of previously published studies. | 2009 | 19251545 |
| seroprevalence of chronic hepatitis b virus infection among taiwanese human immunodeficiency virus type 1-positive persons in the era of nationwide hepatitis b vaccination. | we aimed to assess the impact of nationwide hepatitis b virus (hbv) vaccination program on the seroprevalence of hbv infection among human immunodeficiency virus (hiv)-positive persons in a country where most hbv exposure occurs during the perinatal period or in early childhood. | 2009 | 19259078 |
| hepatitis b seroprevalence and anamnestic response amongst taiwanese young adults with full vaccination in infancy, 20 years subsequent to national hepatitis b vaccination. | the long-term protective effect of hepatitis b virus (hb) vaccination against hb infection and the necessity for routine booster vaccination in young-adult age subsequent to full hb immunization at birth remain issues of some debate currently. this study is aimed at evaluating the seroprevalence of hb infection and the response to hb booster vaccination amongst young-adult university students who had previously undergone full vaccination during their infancy. eight hundred and forty-three subjec ... | 2007 | 17920732 |
| prevalence of antibody reaction with cercopithecine herpesvirus 1 antigen in macaca cyclopis, macaca fascicularis, and papio anubis in taiwan. | a total of 284 non-human primate sera were collected between december 2004 and september 2005 and tested by a commercially available dot immunobinding assay for the antibodies to cercopithecine herpesvirus 1, an alphaherpesvirus with high mortality for infected humans. | 2007 | 17976038 |
| genetic analysis and evaluation of the reassortment of influenza b viruses isolated in taiwan during the 2004-2005 and 2006-2007 epidemics. | influenza b viruses were predominant in taiwan during the 2004-2005 epidemic and both victoria and yamagata lineage viruses co-circulated. a reassortant influenza b virus that contained a victoria lineage hemagglutinin (ha) gene and yamagata lineage neuraminidase (na) gene appeared first in 2002 and became predominant during the 2004-2005 epidemic. during the 2006-2007 epidemic, an influenza b outbreak occurred in taiwan and only victoria lineage viruses circulated. we characterized the viruses ... | 2008 | 17996973 |
| long-term tracking of hepatitis b viral load and the relationship with risk for hepatocellular carcinoma in men. | little is known about the longitudinal course of hepatitis b virus (hbv) load and its relationship with the development of hepatocellular carcinoma (hcc). we conducted a case-cohort study nested within a cohort of 2874 hbv surface antigen-positive male taiwanese government employees aged 30 years or older. hbv genotype and dna levels (i.e. viral load) were tested using polymerase chain reaction-based assays on plasma samples from 112 cases and 1031 non-cases. prediagnostic plasma levels of hbv d ... | 2008 | 17999990 |
| udp-glucuronosyltransferase 1a7 polymorphisms are associated with liver cirrhosis. | variations in the udp-glucuronosyltransferase (ugt) 1a7 gene have been found to be related to the development of hepatocellular carcinoma (hcc). since the pathogenesis of liver cirrhosis is not dissimilar to that of hcc, we hypothesized that ugt1a7 genetic polymorphisms may be associated with liver cirrhosis. pcr-restriction fragment length polymorphism was utilized to determine ugt for 1a7 genotypes for the 159 patients with liver cirrhosis and 263 gender/age matched controls. simple logistic r ... | 2008 | 18054330 |
| somatic mutations at the trinucleotide repeats of androgen receptor gene in male hepatocellular carcinoma. | androgen and androgen receptor (ar) have long been implicated in liver carcinogenesis, especially for the male dominance feature. however, whether ar gene could occur in somatic mutations that might contribute to this process has not yet been studied. dna sequencing and genotyping were conducted for detecting the genetic aberrations of ar gene in 257 primary hepatocellular carcinomas (hccs) and also the dysplastic nodules (dn) from another 11 patients. twenty-one ar somatic mutations causing ami ... | 2007 | 17230529 |
| genetic and epidemiological analysis of influenza virus epidemics in taiwan during 2003 to 2006. | the genetic characterization of taiwanese influenza a and b viruses on the basis of analyses of pairwise amino acid variations, genetic clustering, and phylogenetics was performed. a total of 548, 2,123, and 1,336 sequences of the ha1 genes of influenza a virus subtypes h1 and h3 and influenza b virus, respectively, collected during 2003 to 2006 from an island-wide surveillance network were determined. influenza a virus h3 showed activity during all periods, although it was dominant only in the ... | 2008 | 18256223 |
| analysis of 6381 hepatocellular carcinoma patients in southern taiwan: prognostic features, treatment outcome, and survival. | this hospital-based analysis was conducted to identify prognostic factors of hepatocellular carcinoma (hcc) in a hepatitis b virus endemic area. | 2008 | 18306990 |
| urinary 15-f2t-isoprostane, aflatoxin b1 exposure and hepatitis b virus infection and hepatocellular carcinoma in taiwan. | to evaluate the role of oxidative stress and aflatoxin exposure on risk of hepatocellular carcinoma (hcc), a case-control study nested within a large community-based cohort was conducted in taiwan. baseline urine samples, collected from a total of 74 incident hcc cases and 290 matched controls, were used to determine by enzyme-linked immunosorbent assays the level of urinary 15-f(2t)-isoprostane (15-f(2t)-isop), a biomarker of lipid peroxidation. these samples had been previously analyzed for ur ... | 2008 | 18310087 |
| high prevalence of occult hepatitis b virus infection in patients with b cell non-hodgkin's lymphoma. | several reports recently found that patients with b cell non-hodgkin's lymphoma (nhl) had a higher carrier rate of hepatitis b surface antigen (hbsag). the current study aimed to examine the hepatitis b virus (hbv) infection status of nhl patients in taiwan, an hbv-endemic area. serum hbv and serum hepatitis c virus were measured in 471 nhl patients and 1,013 non-lymphoma cancer patients enrolled between february 2000 and march 2007. furthermore, nested polymerase chain reaction of hbv-dna was u ... | 2008 | 18327583 |
| hepatitis b immunity in adolescents and necessity for boost vaccination: 23 years after nationwide hepatitis b virus vaccination program in taiwan. | the first universal hepatitis b vaccination program for newborns in the world was launched in taiwan in july 1984. most studies on the effectiveness of hepatitis b vaccination focused on the seroprevalence of hbs ag among children under 14 years old. only few studies focused on the seropositivity of anti-hbs among adolescents aged 15-18 years old. the present study aimed to evaluate the impact of the nationwide hepatitis b vaccination program on the immunity to hbv infection and the necessity of ... | 2009 | 19698812 |
| interferon-alpha treatment in children and young adults with chronic hepatitis b: a long-term follow-up study in taiwan. | the short- and long-term benefits of interferon (ifn)-alpha therapy in young patients with chronic hepatitis b (chb) acquiring infection perinatally or during early childhood have been questioned. | 2008 | 18397229 |
| associations between hepatitis c viremia and low serum triglyceride and cholesterol levels: a community-based study. | to evaluate the association of virologic status with serum cholesterol and triglyceride levels in individuals with hepatitis c virus (hcv) infection. | 2008 | 18486265 |
| seroprevalence of viral hepatitis and sexually transmitted disease among adults with recently diagnosed hiv infection in southern taiwan, 2000-2005: upsurge in hepatitis c virus infections among injection drug users. | the purpose of this study was to compare the seroprevalence of viral hepatitis and sexually transmitted disease (std) co-infections among three populations at risk recently diagnosed with hiv infection. | 2008 | 18492625 |
| associations between hepatitis b virus genotype and mutants and the risk of hepatocellular carcinoma. | the risk of hepatocellular carcinoma (hcc) increases with increasing level of hepatitis b virus (hbv) in serum (viral load). however, it is unclear whether genetic characteristics of hbv, including hbv genotype and specific genetic mutations, contribute to the risk of hcc. we examined the hcc risk associated with hbv genotypes and common variants in the precore and basal core promoter (bcp) regions. | 2008 | 18695135 |
| niuchangchih (antrodia camphorata) and its potential in treating liver diseases. | niuchangchih (antrodia camphorata (m. zang & c.h. su) sheng h. wu, ryvarden & t.t. chang) is a basidiomycete endemic to taiwan. it is well known as a traditional chinese medicine (tcm), and taiwanese aborigines used this species to treat liver diseases and food and drug intoxication. the compounds identified in niuchangchih are predominantly polysaccharides, triterpenoids, steroids, benzenoids and maleic/succinic acid derivatives. recent research has revealed that niuchangchih possesses extensiv ... | 2009 | 19061947 |
| occult hepatitis b virus infection in hepatitis b vaccinated children in taiwan. | presence of occult hbv infection in hbv vaccinated children remains largely unknown. the aim of this study was to investigate the prevalence of occult hbv infection among hbv vaccinated children in taiwan. | 2009 | 19070923 |
| peginterferon alfa-2a plus ribavirin for the treatment of dual chronic infection with hepatitis b and c viruses. | dual chronic infection with hepatitis c virus (hcv) and hepatitis b virus (hbv) is common in areas endemic for either virus. combination therapy with ribavirin and pegylated interferon (peginterferon) is the standard of care for patients with hcv monoinfection. we investigated the effects of combination therapy in patients infected with both hbv and hcv (genotypes 1, 2, or 3). | 2009 | 19084016 |
| frequencies of hepatitis b and c infections among haemodialysis and peritoneal dialysis patients in asia-pacific countries: analysis of registry data. | the impact of dialysis modality on the rates and types of infectious complications has not been well studied. the aim of the present investigation was to evaluate the rates of hepatitis c virus (hcv) and hepatitis b virus (hbv) infections in peritoneal dialysis (pd) and haemodialysis (hd) patients in the asia-pacific region. | 2009 | 19096083 |
| [hepatitis b in pregnant women and children]. | in pregnant women and children, the hepatitis b virus can cause acute or chronic hepatitis or liver cirrhosis. perinatally-acquired infection causes persistent infection in 90% of cases and can be avoided through administration of the hepatitis b vaccine and specific immunoglobulin in the first day of life. prevention of mother-to-child transmission requires screening for hepatitis b surface antigen (hbsag) in pregnant women to identify which newborns should be immunized. in some countries this ... | 2008 | 19100233 |
| long-term efficacy of plasma-derived and recombinant hepatitis b vaccines in a rural township of central taiwan. | to assess the differences of long-term efficacy between plasma-derived and recombinant hepatitis b virus (hbv) vaccines and the effectiveness of catch-up vaccination in adolescents with undetectable anti-hbs. | 2009 | 19186203 |
| effect of puberty onset on spontaneous hepatitis b virus e antigen seroconversion in men. | male predominance is a remarkable phenomenon in hepatitis b virus (hbv)-related liver disease. this study elucidated the effects of puberty on spontaneous hepatitis b virus e antigen (hbeag) seroconversion in boys. | 2010 | 19962986 |
| hepatitis b vaccination: the key towards elimination and eradication of hepatitis b. | hepatitis b virus infection is a global health problem. worldwide, about 360 million people are chronically infected with the virus. they continue to spread the virus to others and are themselves at risk of chronic liver diseases and hepatocellular carcinoma. the infection can now be treated by antivirals or interferons and the transmission route can be interrupted. nevertheless, the most effective means is to immunize all susceptible individuals, especially young children, with safe and efficac ... | 2009 | 19231008 |
| hepatitis b virus genotype b has an earlier emergence of lamivudine resistance than genotype c. | hepatitis b virus (hbv) genotype b and c seem not to affect the therapeutic response to lamivudine (3tc). whether a given genotype has an earlier emergence of 3tc resistance remains unclear. we thus conducted this study to elucidate the association of hbv genotype with the emergence of 3tc-resistant strains in taiwanese patients. | 2009 | 20032545 |
| neither diabetes mellitus nor overweight is a risk factor for hepatocellular carcinoma in a dual hbv and hcv endemic area: community cross-sectional and case-control studies. | chronic hepatitis b virus (hbv) and hepatitis c virus (hcv) infections are well-known risk factors for hepatocellular carcinoma, and diabetes mellitus (dm) and overweight have also been reported as risk factors for hepatocellular carcinoma (hcc). we tried to elucidate the roles of dm and overweight in hcc development in a dual hbv and hcv endemic area of southern taiwan. | 2010 | 20051944 |
| human leukocyte antigen-drb1*1101 correlates with less severe hepatitis in taiwanese male carriers of hepatitis b virus. | human leukocyte antigen (hla) class ii molecules are associated with host immune responses against hepatitis b virus infection. male gender is the apparent host factor when someone encounters with the severity of hepatitis. the aim of this study was to investigate the association of the most polymorphic hla class ii allele, human leukocyte antigen-drb1, with the severity of hepatitis in male carriers of hepatitis b virus. in this prospective cohort study, a total of 204 carriers of hepatitis b v ... | 2009 | 19235869 |
| aflatoxin b1 exposure, hepatitis b virus infection, and hepatocellular carcinoma in taiwan. | to evaluate the role of aflatoxin b1 (afb1) exposure on risk of hepatocellular carcinoma (hcc), a case-control study nested within a community-based cohort was conducted. baseline blood and urine samples were used to determine the level of afb1-albumin adducts and urinary afb1 metabolites. conditional logistic regression analysis was used to calculate odds ratios (or) and 95% confidence intervals (95% ci) to assess the effect of afb1 exposure on risk of hcc. the adjusted ors (95% cis) were 1.54 ... | 2009 | 19273485 |
| performance characteristics of two real-time pcr assays for quantification of hepatitis b virus dna. | detection and quantification for hepatitis b virus (hbv) dna has been an essential tool in the clinical setting. we aimed to assess clinical performance of the realart hbv tm pcr (realart) assay and the cobas taqman hbv (cobas) assay. serum levels of hbv dna in 146 treatment-naïve chronic hbv (chb) taiwanese patients (118 males, 47 hbeag + ; mean age, 34.7+/-13.0 y) were determined by both assays. the detection rate by the realart assay was 85.6% (125/146), which was not significantly different ... | 2009 | 19360504 |
| prevalence of human immunodeficiency virus and its association with hepatitis b, c, and d virus infections among incarcerated male substance abusers in taiwan. | taiwan has been facing a rising epidemic of human immunodeficiency virus (hiv) infection since 2004. injection drug users comprised 38.5% of accumulated hiv cases by 2007. this cross-sectional study investigated the seroprevalence of hepatitis b virus (hbv), hepatitis c virus (hcv), hepatitis d virus (hdv), and hiv infection in 753 male substance users who were detained in a detoxification center in taoyuan, taiwan. the subjects were enrolled into the study consecutively between february and oct ... | 2009 | 19382252 |
| a study on sequence variations in pre-s/surface, x and enhancer ii/core promoter/precore regions of occult hepatitis b virus in non-b, non-c hepatocellular carcinoma patients in taiwan. | this study was to investigate the clinical significance and virologic factors of occult hepatitis b virus (hbv) infection in hepatocellular carcinoma (hcc) patients without hepatitis b surface antigen (hbsag) or anti-hepatitis c virus (non-b, non-c) in taiwan. serum hbv dna (occult hbv) was detected in 90 of 222 non-b, non-c hcc patients and 24 of 300 non-b, non-c controls without hcc. of 90 occult hbv-infected hcc patients, the sequences of hbv pre-s/surface, x and enhancer ii/core promoter/pre ... | 2009 | 19431214 |