| the alpha-tocopherol form of vitamin e boosts elastase activity of human pmns and their ability to kill streptococcus pneumoniae. | despite the availability of vaccines, streptococcus pneumoniae remains a leading cause of life-threatening infections, such as pneumonia, bacteremia and meningitis. polymorphonuclear leukocytes (pmns) are a key determinant of disease course, because optimal host defense requires an initial robust pulmonary pmn response to control bacterial numbers followed by modulation of this response later in infection. the elderly, who manifest a general decline in immune function and higher basal levels of ... | 2017 | 28516066 |
| pigr and pecam-1 bind to pneumococcal adhesins rrga and pspc mediating bacterial brain invasion. | streptococcus pneumoniae is the main cause of bacterial meningitis, a life-threating disease with a high case fatality rate despite treatment with antibiotics. pneumococci cause meningitis by invading the blood and penetrating the blood-brain barrier (bbb). using stimulated emission depletion (sted) super-resolution microscopy of brain biopsies from patients who died of pneumococcal meningitis, we observe that pneumococci colocalize with the two bbb endothelial receptors: polymeric immunoglobuli ... | 2017 | 28515075 |
| regionally compartmentalized resident memory t cells mediate naturally acquired protection against pneumococcal pneumonia. | as children age, they become less susceptible to the diverse microbes causing pneumonia. these microbes are pathobionts that infect the respiratory tract multiple times during childhood, generating immunological memory. to elucidate mechanisms of such naturally acquired immune protection against pneumonia, we modeled a relevant immunological history in mice by infecting their airways with mismatched serotypes of streptococcus pneumoniae (pneumococcus). previous pneumococcal infections provided p ... | 2017 | 28513594 |
| towards identifying protective b-cell epitopes: the pspa story. | pneumococcal surface protein a (pspa) is one of the most abundant cell surface protein of streptococcus pneumoniae (s. pneumoniae). pspa variants are structurally and serologically diverse and help evade complement-mediated phagocytosis of s. pneumoniae, which is essential for its survival in the host. pspa is currently been screened for employment in the generation of more effective (serotype independent) vaccine to overcome the limitations of polysaccharide based vaccines, providing serotype s ... | 2017 | 28512452 |
| susceptibility of streptococcus pneumoniae to fluoroquinolones and macrolides in upper respiratory tract infections. | streptococcal species are known as the most common cause of bacterial upper respiratory tract infections (urti). once bacterial infection is diagnosed it demands empirical antibiotic prescription. on the other hand antimicrobial resistance is a global burden in today's medicine. for that reason, knowing of antimicrobial susceptibility patterns in population is an important background for successful treatment of bacterial caused urti. the aim of this study was to analyze s. pneumoniae resistance ... | 2017 | 28511165 |
| invasive pneumococcal disease in infants aged 0-60 days in the united states in the 13-valent pneumococcal conjugate vaccine era. | we identified 53 infants aged 0-60 days with invasive pneumococcal disease (ipd) at 8 children's hospitals in the united states (2005-2015). after the introduction of 13-valent pneumococcal conjugate vaccine (pcv13), ipd caused by pcv13 serotypes decreased ~30% providing some evidence of indirect protection. however, approximately 60% of ipd was still caused by pcv13 serotypes. | 2017 | 28510699 |
| the pneumococcal type 1 pilus genes are thermoregulated and are repressed by a member of the snf2 protein family. | in streptococcus pneumoniae, the type 1 pilus is involved in many steps of pathogenesis, including adherence to epithelial cells, mediation of inflammation, escape from macrophages, and the formation of biofilms. the type 1 pilus genes are expressed in a bistable fashion with cells switching between "on" and "off" expression states. bistable expression of these genes is due to their control by rlra, a positive regulator subject to control by a positive-feedback loop. the type 1 pilus genes are a ... | 2017 | 28507246 |
| fluoroquinolone resistance in streptococcus pneumoniae isolates in germany from 2004-2005 to 2014-2015. | streptococcus pneumoniae is a major cause of bacterial pneumonia, sepsis and meningitis worldwide. prevalence of levofloxacin-resistant s. pneumoniae isolates in germany and associated mutations in the quinolone resistance determining regions (qrdrs), as well as serotype distribution and multi locus sequence types (mlst) are shown. 21,764 invasive s. pneumoniae isolates from germany, isolated in the epidemiological seasons from 2004/05 to 2014/15 were analyzed at the german national reference ce ... | 2017 | 28506425 |
| the evaluation of the sputum antigen kit in the diagnosis of pneumococcal pneumonia. | objective a previously developed sputum antigen detection kit for streptococcus pneumoniae enabled the early diagnosis of pneumococcal pneumonia using sputum samples. we conducted a prospective study to compare the sensitivity of the sputum and urinary antigen kits. methods pneumonia patients who were treated from april 2014 to september 2015 were recruited for the present study. patients with pneumococcal pneumonia who could not participate in the prospective arm of the study were analyzed in t ... | 2017 | 28502926 |
| three decades of follow-up of adults after recovery from invasive pneumococcal pneumonia. | streptococcus pneumoniae infection is the most common cause of community-acquired pneumonia in adults. invasive pneumococcal disease (ipd) carries a high case fatality rate. we investigated the lifespan of adults who recovered from ipd during a 32-year follow-up. | 2017 | 28502330 |
| streptococcus pneumoniae capsular polysaccharide is linked to peptidoglycan via a direct glycosidic bond to β-d-n-acetylglucosamine. | for many bacteria, including those important in pathogenesis, expression of a surface-localized capsular polysaccharide (cps) can be critical for survival in host environments. in gram-positive bacteria, cps linkage is to either the cytoplasmic membrane or the cell wall. despite the frequent occurrence and essentiality of these polymers, the exact nature of the cell wall linkage has not been described in any bacterial species. using the streptococcus pneumoniae serotype 2 cps, which is synthesiz ... | 2017 | 28495967 |
| long-term trends in invasive pneumococcal disease in manitoba, canada. | invasive pneumococcal disease (ipd) remains a significant public health problem in manitoba, canada although publically-funded pneumococcal conjugate (pcv7 and pcv13) and polysaccharide (ppv23) vaccination programs exist. we analyzed routine surveillance and administrative health data to examine trends in ipd rates as these vaccines were introduced. data on all individuals with a laboratory-confirmed diagnosis of ipd between 2001 and 2014 were obtained from the provincial communicable diseases s ... | 2017 | 28494193 |
| high-throughput crispri phenotyping identifies new essential genes in streptococcus pneumoniae. | genome-wide screens have discovered a large set of essential genes in the opportunistic human pathogen streptococcus pneumoniae however, the functions of many essential genes are still unknown, hampering vaccine development and drug discovery. based on results from transposon sequencing (tn-seq), we refined the list of essential genes in s. pneumoniae serotype 2 strain d39. next, we created a knockdown library targeting 348 potentially essential genes by crispr interference (crispri) and show a ... | 2017 | 28490437 |
| zinc metalloproteinase zmpc suppresses experimental pneumococcal meningitis by inhibiting bacterial invasion of central nervous systems. | streptococcus pneumoniae is a leading cause of bacterial meningitis. here, we investigated whether pneumococcal paralogous zinc metalloproteases contribute to meningitis onset. findings of codon-based phylogenetic analyses indicated 3 major clusters in the zmp family; zmpa, zmpc, and zmpb, with zmpd as a subgroup. in vitro invasion assays of human brain microvascular endothelial cells (hbmecs) showed that deletion of the zmpc gene in s. pneumoniae strain tigr4 significantly increased bacterial i ... | 2017 | 28489958 |
| acquisition and transmission of streptococcus pneumoniae is facilitated during rhinovirus infection in families with children. | laboratory and clinical evidence suggests synergy between rhinoviruses and streptococcus pneumoniae in the pathogenesis of respiratory tract infections. however, it is unclear whether rhinoviruses promote pneumococcal acquisition and transmission. | 2017 | 28489454 |
| anti-pneumococcal vaccine-induced cellular immune responses in post-traumatic splenectomized individuals. | splenectomy is associated with increased risk of overwhelming post-splenectomy infections despite proper anti-pneumococcal vaccination. as most studies concentrated on vaccination-induced humoral immunity, the cellular immune responses triggered in splenectomized patients are not yet well studied. the present study aims to investigate this area as it can contribute to the development of more effective vaccination strategies. | 2017 | 28488145 |
| systemic and mucosal immune responses elicited by intranasal immunization with a pneumococcal bacterium-like particle-based vaccine displaying pneumolysin mutant plym2. | pneumolysin (ply) is an important virulence factor in pneumococcal infection and a conserved cholesterol-binding cytotoxin expressed by all serotypes of streptococcus pneumoniae. we previously developed a highly detoxified ply mutant designated plym2 by replacement of two amino acids (c428g and w433f), which lost cytotoxicity but retained the ability to induce neutralizing antibodies. in the present work, we applied bacterium-like particles (blps) as a carrier and immunostimulant for the develop ... | 2017 | 28487097 |
| serotype distribution of streptococcus pneumoniae causing invasive disease in children in the post-pcv era: a systematic review and meta-analysis. | routine immunisation with pneumococcal conjugate vaccines (pcv7/10/13) has reduced invasive pneumococcal disease (ipd) due to vaccine serotypes significantly. however, an increase in disease due to non-vaccine types, or serotype replacement, has been observed. serotypes' individual contributions to ipd play a critical role in determining the overall effects of pcvs. this study examines the distribution of pneumococcal serotypes in children to identify leading serotypes associated with ipd post-p ... | 2017 | 28486544 |
| transcriptional repressor ptvr regulates phenotypic tolerance to vancomycin in streptococcus pneumoniae. | reversible or phenotypic tolerance to antibiotics within microbial populations has been implicated in treatment failure of chronic infections and development of persister cells. however, the molecular mechanisms regulating phenotypic drug tolerance are largely unknown. in this study, we identified a four-gene operon in streptococcus pneumoniae that contributes to phenotypic tolerance to vancomycin (ptv). rna sequencing, quantiative reverse transcriptase pcr, and transcriptional luciferase report ... | 2017 | 28484041 |
| risk factors for influenza-associated severe acute respiratory illness hospitalization in south africa, 2012-2015. | data on risk factors for influenza-associated hospitalizations in low- and middle-income countries are limited. | 2017 | 28480255 |
| an uncommon site of streptococcus pneumoniae colonization leading to recurrent pneumococcal disease. | this report describes a case of relapsing pneumococcal peritonitis. the postulated source of infection was vaginal colonization and secondary adherence of pneumococci to an intrauterine contraceptive device. after immunization with a conjugate pneumococcal vaccine, her antibody levels were observed. she remained infection free at the 2-year follow-up investigation. | 2017 | 28480250 |
| ten-year trends and clinical relevance of the antimicrobial resistance genotype in respiratory isolates of streptococcus pneumoniae. | antimicrobial resistance of streptococcus pneumoniae, especially against β-lactam antibiotics, is a global concern. we aimed to analyze a 10-year trend in the antimicrobial resistance genotype of respiratory isolates of s. pneumoniae and to clarify whether resistance genotypes were correlated with phenotypic drug susceptibility, pathogenicity, and host clinical background. | 2017 | 28472788 |
| necrotizing fasciitis caused by streptococcus pneumoniae. | | 2017 | 28468740 |
| diagnostic practices for suspected community-acquired central nervous system infection in the post-conjugate vaccine era. | the aim of this study was to evaluate diagnostic practices for suspected community-acquired central nervous system (cns) infection in an urban pediatric population. | 2017 | 28463942 |
| dendritic cell-targeting dna-based nasal adjuvants for protective mucosal immunity to streptococcus pneumoniae. | to develop safe vaccines for inducing mucosal immunity to major pulmonary bacterial infections, appropriate vaccine antigens (ags), delivery systems and nontoxic molecular adjuvants must be considered. such vaccine constructs can induce ag-specific immune responses that protect against mucosal infections. in particular, it has been shown that simply mixing the adjuvant with the bacterial ag is a relatively easy means of constructing adjuvant-based mucosal vaccine preparations; the resulting vacc ... | 2017 | 28463465 |
| streptococcus pneumoniae-induced ototoxicity in organ of corti explant cultures. | hearing loss remains the most common long-term complication of pneumococcal meningitis (pm) reported in up to 30% of survivors. streptococcus pneumoniae have been shown to possess different ototoxic properties. here we present a novel ex vivo experimental setup to examine in detail the pattern of hair cell loss upon exposure to different s. pneumoniae strains, therefore recapitulating pathogen derived aspects of pm-induced hearing loss. our results show a higher susceptibility towards s. pneumon ... | 2017 | 28460251 |
| the accessory sec system (secy2a2) in streptococcus pneumoniae is involved in export of pneumolysin toxin, adhesion and biofilm formation. | in streptococcus pneumoniae tigr4, genes encoding a secy2a2 accessory sec system are present within a locus encoding a serine-rich repeat surface protein psrp. mutant strains deleted in seca2 or psrp were deficient in biofilm formation, while the δseca2 mutant was reduced in binding to airway epithelial cells. cell wall protein (cwp) fractions from the δseca2 mutant, but not from the δpsrp mutant, were reduced in haemolytic (pneumolysin) activity. contact-dependent pneumolysin (ply) activity of ... | 2017 | 28456649 |
| a meta-analysis of antimicrobial susceptibility profiles for pneumococcal pneumonia in sub-saharan africa. | pneumonia causes an enormous burden of childhood disease globally, particularly in low- and middle-income countries. pneumococcus is the most common bacterial aetiology of pneumonia; however, antimicrobials are limited and may not adequately address the local epidemiology of the region. | 2017 | 28453405 |
| juglone alleviates pneumolysin-induced human alveolar epithelial cell injury via inhibiting the hemolytic activity of pneumolysin. | streptococcus pneumoniae (the pneumococcus) is an opportunistic pathogen responsible for several human diseases, including acute otitis media, pneumonia, sepsis and bacterial meningitis, and possesses numerous virulence factors associated with pneumococcal infection and pathogenesis. with the capacity to form pores in cholesterol-rich membranes, pneumolysin (ply) is a key virulence factor of s. pneumoniae and causes severe tissue damage during pneumococcal infection. juglone (jg), a natural 1,4- ... | 2017 | 28451868 |
| [major sickle cell syndromes and infections associated with this condition in children in burkina faso]. | this study aims to investigate infections in children with major sickle cell syndrome. | 2017 | 28450986 |
| a case report of parapneumonic pleural effusion caused by streptococcus pneumoniae serotype 19a in a child immunized with 13-valent conjugate pneumococcal vaccine. | simple parapneumonic effusion is a pleural effusion associated with lung infection (i.e., pneumonia). streptococcus pneumoniae remains the most common pathogen causing parapneumonic effusions. in morocco, the pneumococcal conjugate vaccine 13-valent (pcv13) was introduced in the national immunization program in october 2010 in 2 + 1 schedule for prevention of pneumococcal disease, and replaced by the pcv10 in july 2012 in the same schedule. we report a case of parapneumonic pleural effusions cau ... | 2017 | 28449653 |
| position of o-acetylation within the capsular repeat unit impacts the biological properties of pneumococcal serotypes 33a and 33f. | streptococcus pneumoniae (pneumococcus) produces many capsule types that differ in their abilities to evade host immune recognition. to explain these serotype-dependent protective capacities, many studies have investigated capsular thickness or the interaction of the capsule with complement proteins, but the effects of small chemical modifications of the capsule on its function have not been studied. one small chemical modification found frequently among pneumococcal capsules is o-acetylation. p ... | 2017 | 28438972 |
| tigr4 strain causes more severe disease than wu2 strain in a mouse model of streptococcus pneumoniae meningitis: a common pathogenic role for interferon-γ. | streptococcus pneumoniae (s. pneumoniae) meningitis causes debilitating neurological symptoms and acute fatalities in patients, and long-term neurological sequelae in some survivors. current vaccines do not protect against all 94 known s. pneumoniae capsular serotypes, many of which are capable of causing pneumococcal meningitis (pm). we here compare the pathogenic outcomes of two clinically virulent isolates of s. pneumoniae, serotype 3 strain wu2 and serotype 4 strain tigr4, in a murine model ... | 2017 | 28438705 |
| pneumococcal carriage among children after four years of routine 10-valent pneumococcal conjugate vaccine use in brazil: the emergence of multidrug resistant serotype 6c. | in 2010, the 10-valent pneumococcal conjugate vaccine (pcv10) was introduced free of charge in brazil as part of the public immunization program. here we investigated the carriage prevalence, colonization risk factors, capsular types, and antimicrobial resistance among pneumococcal isolates obtained from children in brazil four years after routine pcv10 use. | 2017 | 28431817 |
| antimicrobial resistant streptococcus pneumoniae: prevalence, mechanisms, and clinical implications. | streptococcus pneumoniae is a major cause of pneumonia, meningitis, sepsis, bacteremia, and otitis media. s. pneumoniae has developed increased resistance to multiple classes of antibiotics. | 2017 | 28430673 |
| impact of the pneumococcal conjugate vaccine on serotype distribution of adult non-invasive streptococcus pneumoniae isolates in tokai region, japan, 2008-2016. | the introduction of the 7-valent pneumococcal conjugate vaccine (pcv7) in february 2010 markedly reduced the burden of invasive pneumococcal disease and changed serotype distribution in japan. in november 2013, pcv7 was replaced by the 13-valent pneumococcal conjugate vaccine (pcv13). we investigated the serotype distribution and susceptibility trends of non-invasive streptococcus pneumoniae isolates collected from adult patients. a total of 504 pneumococcal isolates were collected during 4 peri ... | 2017 | 28427991 |
| splenic ly6g(high) mature and ly6g(int) immature neutrophils contribute to eradication of s. pneumoniae. | the spleen plays an integral protective role against encapsulated bacterial infections. our understanding of the associated mechanisms is limited to thymus-independent (ti) antibody production by the marginal zone (mz) b cells, leaving the contribution of other splenic compartments such as the red pulp (rp) largely unexplored despite asplenic patients succumbing to the infection in the first 24 h, suggesting important antibody-independent mechanisms. in this study, using time-lapse intravital im ... | 2017 | 28424248 |
| location in the spleen dictates the function of murine neutrophils. | in this issue of jem, deniset et al. (https://doi.org/10.1084/jem.20161621) provide new data that extend our knowledge on the mechanisms whereby streptococcus pneumoniae is cleared by the spleen. the authors identify novel populations of murine splenic neutrophils that localize in the red pulp and the marginal zone. during the acute phases of s. pneumoniae infection, these populations of splenic neutrophils act in concert with specialized macrophage and b cell populations to provide very rapid i ... | 2017 | 28424247 |
| pneumococcal capsular polysaccharide immunity in the elderly. | immunity to pneumococcal infections is impaired in older people, and current vaccines are poorly protective against pneumococcal disease in this population. naturally acquired immunity to pneumococcal capsular polysaccharides develops during childhood and is robust in young adults but deteriorates with advanced age. in particular, antibody levels and function are reduced in older people. pneumococcal vaccines are recommended for people >65 years old. however, the benefits of polysaccharide and p ... | 2017 | 28424198 |
| nasopharyngeal carriage and antimicrobial susceptibility patterns of streptococcus pneumoniae among children under five in southwest ethiopia. | nasopharyngeal carriage of streptococcus pneumoniae is found to play an important role in the development and transmission of pneumococcal diseases. in this study, we assessed the nasopharyngeal carriage, antimicrobial susceptibility patterns and associated risk factors of s. pneumoniae among children under five. a total of 361 children under five attending the outpatient department of shanan gibe hospital in jimma, southwest ethiopia were enrolled from june to september 2014. nasopharyngeal spe ... | 2017 | 28422083 |
| clinical utility of polymerase chain reaction testing for streptococcus pneumoniae in pediatric cerebrospinal fluid samples: a diagnostic accuracy study of more than 2000 samples from 2004 to 2015. | the aim of this retrospective study was to review the diagnostic accuracy of real-time polymerase chain reaction (pcr) testing of cerebrospinal fluid (csf) samples for streptococcus pneumoniae dna in comparison with traditional bacterial culture. the hypothesis was that pcr is more sensitive than culture and would detect more cases of pneumococcal meningitis, particularly in children treated with antimicrobials before csf sampling occurred. patients younger than 16 years of age who had a csf sam ... | 2017 | 28419005 |
| first report of serotype 23b streptococcus pneumoniae isolated from an adult patient with invasive infection in japan. | serotype 23b streptococcus pneumoniae was isolated from a 67-year-old japanese patient with meningitis. this isolate was susceptible to penicillin g, while genotyped as gpisp with a mutation in a penicillin-binding motif in pbp2b. the 23b isolate was assigned to st11996 that is related to cc439, a dominant group among serotype 23b. | 2017 | 28417006 |
| [description of 3 cases of skin and soft tissue infections caused by streptococcus pneumoniae]. | the role of streptococcus pneumoniae as a causative agent of skin and soft tissue infections (ssti) is unusual and its clinical interpretation is difficult. we describe here three cases of ssti due to s. pneumoniae in patients admitted to the provincial pediatric hospital of misiones, argentina that were detected during 10 years of invasive disease (id) surveillance documented in 2010, 2011 and 2015. these cases involved two girls aged 8 and 7 months old, and a two-year-old male child with diagn ... | 2017 | 28416258 |
| decrease in pneumococcal otitis media cultures with concomitant increased antibiotic susceptibility in the pneumococcal conjugate vaccines era. | to study the change in the incidence and antibiotic susceptibility patterns of streptococcus pneumoniae (spn) in cultures obtained from children with otitis media (om) during the pneumococcal conjugate vaccines (pcvs) era. | 2017 | 28414696 |
| transcriptional organization of pneumococcal psrp-secy2a2 and impact of gtfa and gtfb deletion on psrp-associated virulence properties. | pneumococcal serine-rich repeat protein (psrp) is a glycoprotein that mediates streptococcus pneumoniae attachment to lung cells and promotes biofilm formation. herein, we investigated the transcriptional organization of psrp-secy2a2, the 37-kbp pathogenicity island encoding psrp and its accessory genes. pcr amplification of cdna and rna-seq analysis found psrp-secy2a2 to be minimally composed of three operons: psrp-glya, glyb, and glyc-asp5. transcription of all three operons was greatest durin ... | 2017 | 28408270 |
| age-associated microbial dysbiosis promotes intestinal permeability, systemic inflammation, and macrophage dysfunction. | levels of inflammatory mediators in circulation are known to increase with age, but the underlying cause of this age-associated inflammation is debated. we find that, when maintained under germ-free conditions, mice do not display an age-related increase in circulating pro-inflammatory cytokine levels. a higher proportion of germ-free mice live to 600 days than their conventional counterparts, and macrophages derived from aged germ-free mice maintain anti-microbial activity. co-housing germ-free ... | 2017 | 28407483 |
| epigallocatechin gallate inhibits streptococcus pneumoniae virulence by simultaneously targeting pneumolysin and sortase a. | streptococcus pneumoniae (pneumococcus), the causative agent of several human diseases, possesses numerous virulence factors associated with pneumococcal infection and pathogenesis. pneumolysin (ply), an important virulence factor, is a member of the cholesterol-dependent cytolysin family and has cytolytic activity. sortase a (srta), another crucial pneumococcal virulence determinate, contributes greatly to the anchoring of many virulence-associated surface proteins to the cell wall. in this stu ... | 2017 | 28402019 |
| identification of streptococcus pneumoniae: development of a standardized protocol for optochin susceptibility testing using total lab automation. | purpose. optochin susceptibility is one parameter used in the laboratory to identify streptococcus pneumoniae. however, a single standardized procedure does not exist. optochin is included neither in the current eucast breakpoint tables nor in the clsi performance standards for antimicrobial susceptibility testing. we wanted to establish an evidence-based protocol for optochin testing for our total lab automation. methods. we tested seven different agars and four different reading time points (7 ... | 2017 | 28401155 |
| the interrelationship between phagocytosis, autophagy and formation of neutrophil extracellular traps following infection of human neutrophils by streptococcus pneumoniae. | neutrophils play an important role in the innate immune response to infection with streptococcus pneumoniae, the pneumococcus. pneumococci are phagocytosed by neutrophils and undergo killing after ingestion. other cellular processes may also be induced, including autophagy and the formation of neutrophil extracellular traps (nets), which may play a role in bacterial eradication. we set out to determine how these different processes interacted following pneumococcal infection of neutrophils, and ... | 2017 | 28399692 |
| reduced pu.1 expression underlies aberrant neutrophil maturation and function in β-thalassemia mice and patients. | β-thalassemia is associated with several abnormalities of the innate immune system. neutrophils in particular are defective, predisposing patients to life-threatening bacterial infections. the molecular and cellular mechanisms involved in impaired neutrophil function remain incompletely defined. we used the hbb(th3/+) β-thalassemia mouse and hemoglobin e (hbe)/β-thalassemia patients to investigate dysregulated neutrophil activity. mature neutrophils from hbb(th3/+) mice displayed a significant r ... | 2017 | 28325862 |
| efficient inference of recent and ancestral recombination within bacterial populations. | prokaryotic evolution is affected by horizontal transfer of genetic material through recombination. inference of an evolutionary tree of bacteria thus relies on accurate identification of the population genetic structure and recombination-derived mosaicism. rapidly growing databases represent a challenge for computational methods to detect recombinations in bacterial genomes. we introduce a novel algorithm called fastgear which identifies lineages in diverse microbial alignments, and recombinati ... | 2017 | 28199698 |
| pneumococcal pneumonia requiring hospitalization in us children in the 13-valent pneumococcal conjugate vaccine era. | the impact of pcv13 on a number of clinical aspects of pneumococcal pneumonia (pp) in children has not been reported. we compared the serotype distribution, antibiotic susceptibility, and outcomes of children with pp 4 years before and 4 years after the introduction of pcv13. | 2017 | 28199482 |
| [atypical respiratory tract infections in adult patients in the primary care]. | respiratory tract infections remain one of the most frequently encountered acute illnesses in the primary care. atypical germs along with streptococcus pneumoniae are an important cause of community-acquired pneumonia. most infections caused by atypical germs are mild or moderate but some of them might cause a severe disease with important morbidity and mortality. diagnosis of community-acquired pneumonia remains a challenge in the primary care. on the other hand some of them are reported to be ... | 2016 | 28525235 |
| a case of post-pneumococcal acute glomerulonephritis with glomerular depositions of nephritis-associated plasmin receptor. | we report the case of a 12-year-old girl who was referred to our hospital with anuria associated with pneumonia. on admission, the patient's blood test results revealed severe renal failure, hypoproteinemia, and hypocomplementemia. her urinalysis results revealed hematuria, proteinuria, and a positive titer for streptococcus pneumoniae. s. pneumoniae was also detected in her sputum and blood cultures. the patient was diagnosed with post-pneumococcal acute glomerulonephritis (agn) with acute rena ... | 2015 | 28509278 |
| multidrug resistant streptococcus pneumoniae in a case of splenectomy. | | 1998 | 28775501 |
| molecular analysis of virulence factors of streptococcus pneumoniae. | | 1997 | 28621902 |
| regulation of competence for genetic transformation in streptococcus pneumoniae. | | 1997 | 28621899 |
| pneumococcal dacryocystitis: three interesting cases. | | 1995 | 28769247 |