| feline malignant giant cell tumor of bone associated with c-type virus particles. | a malignant giant cell tumor of bone in a cat is described. numerous c-type particles were found budding from the neoplastic cells. viruses have not previously been associated with malignant bone noeplasms in cats. | 1976 | 185002 |
| [ultrastructural aspects of nonsynaptic interactions between neurons (interneuronal transport)]. | | 1976 | 185029 |
| plasticity of ponto-geniculo-occipital waves during paradoxical sleep after frontal lobe lesions in the cat. | | 1976 | 185079 |
| evidence of depolarization-induced camp increase in the superior cervical ganglion of several mammalian species. | 1. the activation of camp synthesis resulting from exposure of superior cervical ganglion (scg) tissue to high k+ solutions observed in calf has been found to occur in three other mammalian species, namely rat, cat, and rabbit. 2. the camp accumulation in the ganglion of calf is much less pronounced than that occurring in the other species. the enhancing effect oftheophylline on the increase of camp was found to be much greater in the scg of calf than in that of other species. when veratridine w ... | 1976 | 185121 |
| [effects of monoamine-related compounds on the sleep-awake cycle in rabbits]. | the role of 5ht and na in the regulation of the sleep-awake cycle, especially in the triggering mechanisms of paradoxical sleep (pt), was studied in rabbits using reserpine, parachlorophenylalanine (pcpa), alpha-methyl-p-tyrosine (alpha-mt) and alpha-methyl -m-tyrosine (alpha-mmt). 1) reserpine (0.5 mg/kg, i.v.) caused a diphasic action on the brain electrical activity in rabbits: an initial activation pattern in the eeg which continued to 2approximately3 hr, was followed gradually by a slow wav ... | 1976 | 185127 |
| an electrophysiological study of the sacral parasympathetic pathway to the colon of the cat. | 1. electrophysiological techniques were used to study the sacral parasympathetic pathway to the colon of the cat. 2. electrical stimulation of the sacral ventral roots or the pelvic nerve elicited contractions of the colon and firing in nerve filaments on the serosal surface of the colon. both responses were markedly reduced by the administration of ganglionic blocking agents. it is concluded that sacral preganglionic fibres to the colon make synaptic contacts with extramural ganglion cells. the ... | 1976 | 185366 |
| the presence of leukaemia (lymphosarcoma) and feline leukaemia virus (felv) in cats in the netherlands. | | 1976 | 185459 |
| nucleotide sequences in mouse dna and rna specific for moloney sarcoma virus. | complementary dna (cdna) synthesized by moloney murine sarcoma virus (m-msv) was separated into two parts, the first, termed msv-specific cdna, composed of nucleotide sequences found only in m-msv viral rna, and the second, termed msv-mulv common cdna, composed of nucleotide sequences that were found in both m-msv and murine leukemia virus (mulv) viral rnas. rna complementary to the msv-specific cdna was not found in several other msv isolates, nor in ecotropic mulv, mouse mammary tumor virus, o ... | 1976 | 185623 |
| studies on the safety and efficacy of an intranasal feline rhinotracheitis-calici virus vaccine. | | 1976 | 185775 |
| control of feline leukaemia virus infection. | | 1976 | 185780 |
| effect of cholecystokinin on the adenylate cyclase activity in cat sphincter of oddi. | | 1976 | 185882 |
| effects of lioresal on presynaptic and postsynaptic inhibition in the spinal cord of the cat. | | 1976 | 185884 |
| azathioprine: effects on neuromuscular transmission. | the neuromuscular effects of azathioprine were examined in the in-vivo cat soleus muscle preparation. in concentrations ranging from 10 to 1,000 mug/kg, administered intra-arterially, the agent caused motor axons to fire repetitively and produced a dose-related increase in the force of contraction. the drug reversed neuromuscular blockage produced by d-tubocurarine and potentiated the neuromuscular blockade produced by succinylcholine. the effects of theophylline, a phosphodiesterase inhibitor, ... | 1976 | 185925 |
| [pathogenesis of spontaneous diabetes mellitus in the cat. ii. acidophilic adenoma of the pituitary gland and diabetes mellitus in 2 cases]. | | 1976 | 186021 |
| in vivo measurement of pyridine nucleotide fluorescence from cat brain cortex. | a modification of the methods is described which makes it possible to measure pyridine nucleotide fluorescence from the brain cortex in vivo without interference from movement and hemodynamic artifacts. movement artifacts were eliminated by the use of a window technique. fluorescence changes due to changes in hemoglobin oxygenation have been eliminated by measuring fluorescence at an isobestic wavelength of the hemoglobin-oxyhemoglobin reaction. the interference due to changes in red blood cell ... | 1976 | 186025 |
| inputs to trigeminal brain stem neurones from facial, oral, tooth pulp and pharyngolaryngeal tissues: ii. role of trigeminal nucleus caudalis in modulating responses to innocuous and noxious stimuli. | trigeminal (v) tractotomy and cold block of synaptic transmission in v nucleus caudalis were used to show that caudalis modulates the responses to innocuous and noxious stimuli of single v main sensory-oralis neurones recorded in anaesthetized or decerebrate cats. cold block caused a reversible depression of mechanosensitivity of 91 of 105 v-thalamic relay and non-relay cells tested; v tractotomy also decreased sensitivity. the possibliity that the effects observed with cold block of caudalis we ... | 1976 | 186152 |
| power spectral analysis of eeg activity obtained from cortical and subcortical sites during the vigilance states of the cat. | there is considerable evidence that the raphé system and the region of the nucleus tractus solitarious (nts), including the area postrema, play significant roles in slow-wave sleep mechanisms and in eeg synchronization. studies of the interactions between these systems and the neocortex are much needed. if neuronal activity in these lower brainstem regions regulates the degree of cortical synchrony then a high degree of correspondence between the eeg of the area postrema or raphé complex with th ... | 1976 | 186162 |
| inhibitory and facilitatory areas of the dorsal medulla mediating acth release in the cat. | to define the role of the dorsal medulla in the control of release of acth, the authors stimulated electrically (30 sec, 100 mua, 50 hz) 50 sites in the vicinity of the solitary nuclei of 11 cats anesthetized with chloralose/urethane. responses of arterial pressure to electrical stimulation were not correlated significantly with release of acth. indirect effects of changes in arterial pressure could not explain changes in release of acth. concentrations of acth were measured by radioimmunoassay. ... | 1976 | 186251 |
| inhibitory and facilitatory areas of the rostral pons mediating acth release in the cat. | to define the role of the rostral pons in the control of release of acth, we stimulated electrically (30 sec, 200 mua, 50 hz) 128 sites in the dorsal rostral pons of 20 cats anesthetized with chloralose/urethane. responses of arterial pressure to electrical stimulation were prevented by lesions placed previously in the medulla. plasma concentrations of acth were measured by radioimmunoassay. active areas consisted of three regions: 1) lateral inhibitory: locus subcoeruleus and anteroventral locu ... | 1976 | 186252 |
| in vivo effects of some tertiary alkylaminoethyl esters with choline acetyltransferase inhibitory properties. | the tertiary nitrogen derivatives of two choline esters, chloroacetylcholine and acrylcholine, known to inhibit choline acetyltransferase (chac) in vitro, were tested for their effects in the whole animal, including peripheral and central cholinergic systems. these esters are n,n-dimethylaminoethyl chloroacetate (cl-dma) and n,n-dimethylaminoethyl acrylate (acryl-dma). the peripheral preparations studied included a neuromuscular junction, a sympathetic ganglion and a postganglionic parasympathet ... | 1976 | 186280 |
| localization of evoked potentials in the digastric, masseteric, supra- and intertrigeminal subnuclei of the cat. | extracellular focal potentials were evoked and mapped in the trigeminal motor nucleus and its surrounding borderzone in the cat. graded electrical stimulation was used for orthodromic and antidromic excitation of the masseteric and digastric motoneurones and for orthodromic stimulation of the lingual and inferior alveolar nerves. the method of referring horsley clarke coordinates of microelectrode recording positions to their location of the actual histological section was studied and the total ... | 1976 | 186294 |
| expression of feline type-c virus in normal and tumor tissues of the domestic cat. | tumor and normal tissues from domestic cats were examined for felv and rd-114 specific nucleic acids and proteins. virus-positive tissues showed a 100- to 200-fold higher level of felv and a 200- to 400-fold higher level of felv p30 than virus-negative tumors and normal cat tissues. in contrast, the levels of rd-114 viral rna and p30 antigen were comparable in the majority of tumorous and normal tissues examined. when the dna of these tissues was examined for felv-related sequences, the virus-po ... | 1976 | 186414 |
| natural immunity in cats to feline leukemia viral antigens. | an isotopic antiglobulin assay was developed to measure antibodies in "normal" cats to focma, a cell surface antigen associated with immunity to felv-induced tumors. the assay was shown to be specific for detecting focma antibody by several criteria including a correlation with cell membrane immunofluorescence and absorption tests. antibody to focma developed following felv infection and was expressed in heterologous species. in combination with an assay for antibody to felv p30, the major virio ... | 1976 | 186536 |
| effects of cyclic nucleotides on mammalian motor nerve terminals. | this research examined the effects of several cyclic nucleotides on in vivo cat soleus nerves and muscles. the reagents were administered by rapid close intra-arterial injection while electrical activity in single motor axons and contractile activity in the whole muscle were monitored. cyclic n6-2'-o-dibutyryl adenosine 3',5'-monophosphate (dibutyryl camp) initiated bursts of action potentials in unstimulated axons. it also caused the occurrence of stimulus bound repetitive potentials in stimula ... | 1976 | 186584 |
| a role of cyclic nucleotides in neuromuscular transmission. | this research explored the possibility that cyclic nucleotides are part of the excitation-secretion sequence in mammalian motor nerve terminals. a series of reagents known to react with the enzymes that synthesize and degrade cyclic nucleotides or that are effectors of cyclic nucleotide actions were administered to in vivo cat soleus nerve-muscle preparations. the reagents were administered by rapid close intra-arterial injection while electrical activity in single motor axons and contractile ac ... | 1976 | 186585 |
| feline oncornavirus-associated cell membrane antigen. vi. cytotoxic antibody in cats exposed to feline leukemia virus. | feline leukemia virus (felv)-infected specific pathogen-free (spf) cats, normal uninfected spf cats, and healthy cats from leukemic households were tested for antibody reactive to the feline oncornavirus-associated cell membrane antigen (focma)-containing target cell line fl-74 by microcytotoxicity and indirect membrane immunofluorescence. of the infected spf animals, 81% showed concordant reactivity for the two tests. in contrast, only 55% of the healthy cats known to be naturally exposed to fe ... | 1976 | 186623 |
| cholinergic nature of the primary afferent vagus synapsed in cross anastomosed superior cervical ganglia. | | 1976 | 186680 |
| relation between oxidative metabolism and slow rhythmic potentials in mammalian intestinal muscle. | intact muscle layers separated from the small intestine of the cat were mounted in a specially designed chamber to measure electrical slow waves and nadh fluorescence simultaneously. cooling the muscle to 17 degrees eliminated slow waves and simultaneously increased the level of fluorescence. likewise, superfusing the muscle with a n2-bubbled glucose-free krebs solution decreased the amplitude of slow waves and concomitantly increased fluorescence emission. in both cases, return to normal condit ... | 1976 | 186793 |
| alpha receptor influence on lung surfactant. | | 1976 | 186816 |
| neurohumoral correlates of sleep: further biochemical and physiological characterization of sleep perfusates. | twenty cats were prepared surgically with electrodes for recording the eeg, eye movements and emg and a push-pull cannula system in the midbrain reticular formation (mrf) allowing the extraction of perfusates during wakefulness or rem sleep. proteins in the perfusates were analyzed by isoelectric focusing (ief) polyacrylamide gels and sodium dodesyl sulphate (sds) slab gels. in addition analysis of glycoproteins was done by gas chromatography. in some cats the contribution of cerebrospinal fluid ... | 1976 | 186818 |
| effect of thyrotropin-releasing hormone (trh) and antidepressant agents on brain stem and hypothalamic multiple unit activity in the cat. | the eeg and mua (multiple unit activity) of mesencephalic reticular formation (mrf), area hypothalami posterior (ph), and area hypothalami anterior (ah) were studied in chronically implanted freely moving cats. the effects of thyrotropin-releasing hormone (trh) and some antidepressant agents were tested on neuronal activity. desipramine and imipramine resulted in a dose-dependent decline of mua of all structures with the most significant decrease of activity in ph. a single injection of trh resu ... | 1976 | 186834 |
| depression of rem sleep in cats by nisoxetine, a potential antidepressant drug. | nisoxetine, a potent and specific inhibitor of norepinephrine uptake, suppressed rem sleep in cats. oral doses as small as 0.1 mg/kg were effective during the first 2 1/2 hours of a recording session; 0.25 mg/kg, for 5 hours. the amount of slow wave sleep increased in cats that received 0.1-1.0 mg/kg of nisoxetine. these changes in sleep pattern resemble those reported after treatment with somewhat higher doses of tricylic antidepressants. | 1976 | 186850 |
| effects of methysergide in cats deprived of paradoxical sleep. | methysergide maleate, a 5-hydroxytryptamine receptor blocker, was administered to cats deprived of paradoxical sleep for 48 hours. during the first six hours after methysergide, the latency to the first slow-wave sleep and paradoxical sleep episodes was increased and total sleep time decreased. the decrease in sleep reflects a loss of paradoxical sleep, while the amount of slow-wave sleep remained unchanged. slow-wave sleep time, though unchanged in amount, was displaced to the end of the six-ho ... | 1976 | 186853 |
| laboratory diagnosis of viral and other infectious diseases. | | 1976 | 186928 |
| the herpesviruses. | | 1976 | 186929 |
| [mechanism of internal inhibition (role of the sympathetic nervous system in sleep phenomena)]. | it has been shown on cats that the role of the sympathetic nervous system in sleep phenomena is of an adaptive nature and is effected through chain neurohormonal reactions in which adrenaline possessing a two-phase action plays a major part: it induces excitation followed by sleep. sleep is regarded as a variety of internal inhibition, elaborated as an adaptive reaction to the changing conditions of environment, which later becomes a behavioral reaction. | 1976 | 186977 |
| [experimental study of the organotropic side-effect properties of polymyxin b]. | toxicity of soviet polymyxin b and its effect on the central peripheral nervous system, blood circulation, respiration, smooth muscles, functional liver and kidney state, growth and development of young animals, the picture of the peripheral blood were studied in acute and chronic experiments on various species of animals. it was found that polymyxin b had a suppressing effect on the peripheral n-cholinoreactive systems of the neuromuscle synapses of the skeletal muscles and ganglia of the sympa ... | 1976 | 187113 |
| effect of propranolol on the relationship between atrial systolic pressure and type a atrial receptor discharge in cats. | the responses of type a atrial receptors to graded infusions of saline and large doses of propranolol were examined in anesthetized cats. infusion of saline raised the mean atrial pressure, but usually the amplitude of the atrial a wave was reduced. in general the receptor discharge was unaffected. propranolol reduced the discharge from the control level when it was injected in doses no less than 4 mg/kg. infusions of saline after propranolol resulted in an increase in the discharge and the incr ... | 1976 | 187131 |
| ultrastructural comparison of bovine leukemia virus (blv) with c-type particles of other species. | | 1976 | 187149 |
| reexamination of cerebellar responses to stimulation of sensorimotor areas of the cerebral cortex. | | 1976 | 187279 |
| [effect on paradoxal sleep of experimental limbic epilepsy induced by intraseptal injection of ouabain]. | limbic epilepsy secondary to intraseptal injection of ouabain induces a suppresion of paradoxical sleep, for a duration of 10 to 30 hours, followed by progressive recuperation of paradoxical sleep without any rebound phenomenon. a reappearance of a normal electrical activity is necessary for a rapid restoration of paradoxical sleep. when septal or hippocamp-geniculate spikes persist the recovery is slower and smaller. | 1976 | 187285 |
| observations on recovery mechanisms from feline viral rhinotracheitis. | experiments were designed to determine immunological mechanisms responsible for controlling dissemination of feline rhinotracheitis virus in feline cell cultures. virus infected cells could be destroyed by three mechanisms--antibody and complement mediated lysis, direct lymphocyte cytotoxicity and antibody dependent cell-mediated cytotoxicity. this latter immune parameter was mediated by both lymphocytes and macrophages and varied in extent in different cats. to ascertain the potential importanc ... | 1976 | 187300 |
| [psychotoxicology (author's transl)]. | | 1976 | 187340 |
| chronic labile hypertension produced by lesions of the nucleus tractus solitarii in the cat. | bilateral electrolytic lesions of the nucleus tractus solitarii (nts) were made at the level of the obex in seven cats. within 1 hour the mean arterial pressure (map) rose to a maximum of 144 mm hg (141% of control), and by 7 hours heart rate reached a peak of 236 beats/min (148% of control). the baroreceptor reflexes were abolished. after 24 hours the arterial pressure became extremely labile, with variations of 80-100 mm hg observed. the lability occurred spontaneously and during behaviors tha ... | 1977 | 187359 |
| further studies on the mechanisms controlling prostaglandin biosynthesis in the cat adrenal cortex: the role of calcium and cyclic amp. | in light of previous studies which have implicated prostaglandin (pg) formation as a link in acth-induced steroid production by isolated cat adrenocortical cells, experiments were carried out to provide additional information regarding the role of pgs in adrenal steroidogenesis and their interactions with calcium and cyclic amp. perfusion of cat adrenal glands with locke's solution plus beta(1-24)-acth resulted in an immediate increase in pgf2alpha release, which rapidly declined to basal levels ... | 1977 | 187409 |
| specific and nonspecific multiple unit activities during the onset of pentylenetetrazol seizures. ii. acute lesions interrupting nonspecific system connections. | nonspecific cortical, thalamic, mesencephalic, and pontine multiple unit activities (mua) and changes in eeg and mus of the sciatic nerve after threshold pentylenetetrazol activation were studied in three groups of animals in which neuronal connections were interrupted at three different levels of the central nervous system: spinal, mesencephalic, and prethalamic. maximal increments of nonspecific mua and maximal increments and maximal decrements of sciatic mua after pentylenetetrazol from each ... | 1976 | 187424 |
| the pathogenesis of fever: neurochemical aspects. | | 1976 | 187561 |
| ultrastructural and biochemical evidence for a steroid-containing secretory organelle in the perfused cat adrenal gland. | a correlative study of the ultrastructural and biochemical effects of acth on fasciculata cells was carried out on the isolated cat adrenal gland perfused in situ with locke's solution. the outstanding morphologic feature of cortical cells exposed to microunit acth concentrations for 40 min was the abundance of electron-dense granules (0.2-0.4 mum). these organelles were observed in small groups in close proximity to the golgi region and to the cell membrane. morphometric and biochemical analysi ... | 1977 | 187604 |
| feline leukemia virus infection: age-related variation in response of cats to experimental infection. | sixty-seven specific-pathogen-free cats of various ages (newborn, 2 wk, 1 mo, 2 mo, 4 mo, and 1 yr) were inoculated ip with either the rickard (r) or the kawakami-theilen (kt) strain of feline leukemia virus (felv). susceptibility to felv was judged by induction of a) felv group-specific antigens (gsa) in leukocytes, b) felv-related disease, c) antibody to feline oncornavirus-associated cell membrane antigen (focma), and d) virus-neutralizing (vn) antibody. susceptibility to felv-decreased with ... | 1976 | 187771 |
| characterization of feline t-and b-lymphocytes and identification of an experimentally induced t-cell neoplasm in the cat. | membrane markers of feline t- and b-lymphocytes were identified for further investigation of leukemogenesis in the cat. feline t-cells formed spontaneous erythrocyte rosettes with guinea pig (gpe) and rat erythrocytes (re). the receptors for gpe and re were separate entities and expressed independently on lymphoid cell membranes. the re receptor appeared to be present only on more mature or differentiated t-cells, whereas the gpe receptor reacted with a broader population that included less diff ... | 1976 | 187781 |
| lymphocyte mitogen reactivity and enumeration of circulating b- and t-cells during feline leukemia virus infection in the cat. | mitogen-induced blast transformation of peripheral blood lymphocytes and quantitative changes in circulating t- and b-cells were studied serially in cats inoculated with feline leukemia virus (felv). concanavalin a-induced blast transformation sharply declined beginning at 5 weeks post inoculation (pl) in felv-infected cats when compared to age-matched uninfected control cats. similar but less consistent changes were seen in responses to pokeweed mitogen-induced stimulation. in most infected kit ... | 1976 | 187790 |
| humors and diarrhea. | | 1977 | 187939 |
| the effects of naltrexone in the chronic spinal dog and acute spinal cat; possible interaction with naturally-occurring morphine-like agonists. | | 1976 | 187942 |
| evidence for a prejunctional role of cyclic nucleotides in neuromuscular transmission. | | 1976 | 187946 |
| morphine, enkephalin and the substantia gelatinosa. | | 1976 | 187952 |
| frequency characteristics of the impulse decoding ratio between the spinal afferents and efferents in the stretch reflex. | | 1976 | 188071 |
| blood flow in red and white muscle: relationship to metabolism development and behavior. | | 1976 | 188073 |
| phosphatidylethanolamide derivatives of prostaglandins e1 and e2. | prostaglandins e1 (pge1) and e2 (pge2) have been coupled with the amine group of phosphatidylethanolamine (pe) by means of dicyclohexylcarbodiimide. these complexes basically mimic the relaxant and contractile effects of the corresponding free prostaglandins (pgs) on various smooth muscle preparations, but exhibit a delayed onset of action and a lower affinity for the pg receptors. the complexes are comparable with the free, parent pgs, in their intrinsic activities. the same holds true for the ... | 1976 | 188074 |
| [feline leukaemia or lymphosarcoma (author's transl)]. | | 1977 | 188210 |
| endogenous prostaglandins as regulators of autonomic neurotransmission in the rabbit heart. | | 1976 | 188279 |
| mechanisms of psychosomatic disease in animals. | | 1976 | 188326 |
| histologic classification and further characterization of tumors in domestic animals. | | 1976 | 188327 |
| therapy of neoplasia in domestic animals. | | 1976 | 188328 |
| neuronal activity specific to rem sleep and its relationship to breathing. | the search for the neural substrate of a state of consciousness has led to the expectation that there may be neurons which discharge tonically and rhythmically during that state alone. we have now recorded in the cat the first evidence of neurons whose rhythmic discharge is consistent with the hypothesis of a tonically active neural substrate for rapid eye movement (rem) sleep. these neurons, located in the area of gigantocellular and lateral medullary tegmental fields, begin rhythmically discha ... | 1977 | 188520 |
| contribution of the frontal lobes to modulation of phasic activities in the oculomotor system during paradoxical sleep in the cat. | | 1977 | 188522 |
| caudate influence on transmission in the cuneate nucleus. | | 1977 | 188524 |
| eye movement-associated discharge in brain stem neurons during desynchronized sleep. | the relationship between isolated eye movement during desynchronized sleep and unit discharge in the pontine brain stem was investigated during spontaneously occurring desynchronized sleep episodes in cats. units histologically localized to the gigantocellular tegmental field (ftg) showed the earliest and most prominent discharge rate increases relative to eye movement onset. inflection points for discharge rate increases of these reticular elements peaked 150-100 msec before eye movement onset ... | 1977 | 188525 |
| cat sleep: a unique first night effect. | longitudinal sleep studies in chronically implanted cats revealed a unique first night effect. unlike other species, during the first 24 hr of sleep recording, the electroencephalogram and reticular formation multiple unit activity revealed more rapid eye movement sleep occurred than during subsequent 24 hr recording sessions. in addition, higher rapid eye movement to slow wave sleep ratios were observed for the first 24 hr as compared to the following days. an increase in wakefulness and decrea ... | 1976 | 188526 |
| analysis of circulation of neuronal activity in the waking cortex. | it is well known that the rhythmic activity of the cerebral cortex is closely associated with a highly organized circulation of neuronal impulses through the networks in which the activity develops. the present study has attempted to determine by quantitative methods, the consistency of this circulation and of its association with the cortical waves, over relatively long periods. cortical gross waves and neuronal activity have been recorded by means of arrays of extracellular microelectrodes, in ... | 1976 | 188527 |
| tetanic fade during partial transmission failure produced by non-depolarizing neuromuscular blocking drugs in the cat. | 1. a comparison has been made of the effects of three acetylcholine antagonists--hexamethonium, tubocurarine and pancuronium--on maximal tetani of limb muscles of cats under chloralose anaesthesia. in most experiments, the indirectly stimulated soleus muscle was studied, but observations were also made on the tibialis anterior and flexor digitorum longus muscles. 2. when neuromuscular block was produced by intra-arterial injections of the acetylcholine antagonists, tetanic tension, though depres ... | 1976 | 188580 |
| effects of clonidine on vascular responses in kidney and hindlimbs of cats. | 1. cardiovascular reflexes to intravenous adrenaline and histamine and to carotid occlusion were studied in the renal vasculature, and direct effects of noradrenaline and clinidoine were compared in renal and hindlimb vascular beds in anaesthetized cats. 2. unlike its reported effects on cardiovascular reflexes in the hindlimbs, clonidine depressed all three reflexes in the kidneys. 3. noradrenaline caused vasoconstriction when given directly into both renal and hindlimb circulartions, but cloni ... | 1976 | 188581 |
| parathyroid hormone-mediated incorporation of 32p-orthophosphate into phosphatidic acid and phosphatidylinositol in renal cortical slices. | parathyroid hormone increased the incorporation of na2h32po4 into phosphatidic acid and phosphatidylinositol in cat renal cortical slices. incorporation was not observed into any other phospholipid. the effects were seen as early as one minute for phosphatidic acid and ten minutes for phosphatidylinositol. 8-bromoadnosine 3',5'-monophosphate did not mimic the effects of parathyroid hormone. concentrations of parathyroid hormone, 1 x 10(-8)m to 1 x 10(-7)m, which increased the incorporation of 32 ... | 1976 | 188626 |
| subsensitivity of presynaptic alpha-adrenoceptors after exposure to noradrenaline. | | 1977 | 188661 |
| integration in descending motor pathways controlling the forelimb in the cat. 2. convergence on neurones mediating disynaptic cortico-motoneuronal excitation. | with intracellular recording from forelimb motoneurones the spatial facilitation technique has been used to investigate interaction between descending pathways and forelimb afferents. as previously shown for the hindlimb, pyramidal volleys effectively facilitate interneuronal transmission in reflex pathways from different primary afferents. evidence is presented suggesting disynaptic excitation from corticospinal fibres of interneurones in the reciprocal ia inhibitory pathway. interneurones of o ... | 1976 | 188674 |
| [electrical activity of layers of isolated cortex during drowsiness and different sleep stages]. | in cats with isolated cerebral cortex, with the aid of electordes indwelled into different cortical layers, first electrographic changes during onset of sleep were shown to occur, as with intact cortex, in the lower layers of the isolated cortex. 3-4 months after the cortex isolation, changes of electrical activity during sleep occured simultaneously in the cortex of both hemispheres. awakening produced desynchronization of electrical activity in all cortical layers of both hemispheres. origin o ... | 1976 | 188689 |
| [sympathetic ganglion function in the presence of disrupted acetylcholine synthesis]. | | 1976 | 188690 |
| [effect of methylene blue on transmission of excitation at peripheral autonomic synapses]. | | 1976 | 188691 |
| expression of aleutian mink disease antigen in cell culture. | infection of crfk feline kidney cells with aleutian disease vurus leads to production of virus-induced antigen(s) in the nucleus which could be demonstrated by the fluorescent-antibody technique. the number of fluorescent nuclei was lineraly dependent on the dilution of the inoculum, but rarely exceeded 20% of the cells. aleutian disease nuclear antigen was only transiently detectable. the virus-induced antigen was detected after infection of cells of several divergent species; however, the crfk ... | 1977 | 188765 |
| horizontal transmission of feline leukemia virus under natural conditions in a feline leukemia cluster household. | ten post-weanling 4-month-old cats, designated "tracers", were placed in a feline leukemia cluster household to determine the efficiency of horizontal transmission of feline leukemia virus (felv). the tracer cats were confirmed as negative for prior exposure to felv. following the placement in the leukemia cluster environment, the tracer cats were serologically monitored at intervals of 3-6 weeks for a total period of 1 year. the tests employed included the detection of felv using fixed-cell imm ... | 1977 | 188773 |
| virus isolation test for feline leukemia virus. | a method was developed for detecting feline leukemia virus (felv) infection in cats by coculturing separated blood lymphocytes and platelets with clone 81 cells carrying a murine sarcoma genome but free of leukemia virus (s+l-). felv caused cell transformation that was easily visible 3-12 days after infection. this method is simple, sensitive, and easily read; it has the advantage of directly detecting infectious felv rather than viral antigens. | 1977 | 189037 |
| detection of complement-dependent lytic antibodies in sera from feline leukemia virus-infected cats by the chromium-51 release assay. | sera from feline leukemia virus-infected cats lysed fl74 cells in the presence of an appropriate complement source; lysis was detected with the use of the 51 cr release method. serum complement from both rabbits and guinea pigs mediated lysis. partial correlation of results was obtained from preliminary comparisons of lysis and immunofluorescence tests with the use of fl74 cells as targets. | 1977 | 189040 |
| horizontal transmission of feline leukemia virus under experimental conditions. | thirty-seven specific-pathogen-free (spf) cats ranging from newborn to 1 year were inoculated with the rickard strain of feline leukemia virus (felv). each inoculated cat shared a cage with a control spf cat for 40 weeks post inoculation. after 4-5 weeks, 20 of the inoculated cats became group-specific antigen (gsa)-positive; the other 17 remained gsa-negative but developed virus neutralizing and feline oncornavirus cell membrane-associated antigen antibody titers. seventeen of the control cats ... | 1977 | 189052 |
| fine structure of epithelial cells of lieberkühn's crypts in feline panleukopenia. | electron microscopic observation was carried out on epithelial cells of lieberkühn's crypts of cats naturally affected with feline panleukopenia. the most important change was the replication of feline panleukopenia. the most important change was the replication of feline panleukopenia virus in the nucleus with associated alterations in the lining epithelial cells of the crypts. in these cells in the early stage of infection, virus particles 20 nm in average diameter were found either singly or ... | 1976 | 189222 |
| studies on the possible contribution of a peripheral presynaptic action of clonidine and dopamine to their vascular effects under in vivo conditions. | the functional consequences of drug-induced stimulation under in vivo conditions of alpha-adrenoceptors and dopamine receptors at vascular adrenergic nerve endings (presynaptic receptors) was studied in the autoperfused hindquarters or hindlegs of cats anaesthetized with urethane. the changes in perfusion pressure in response to electrical stimulation of the lumbar sympathetic chain were taken as a measure of noradrenaline release from the vascular adrenergic nerves. presynaptic inhibitory alpha ... | 1976 | 189225 |
| further evidence for the involvement of camp in central blood pressure regulation. | in order to test the hypothesis that the activity of cardiovascular centres is determined by their content of camp a number of drugs which influence the activity of either phosphodiestase or adenylcyclase were injected in doses of 100-1000 mug/kg into the lateral cerebral ventricle of cats. the effects on blood pressure and heart rate were studied. the phosphodiesterase inhibitors papaverine, carbocromene, theophylline and caffeine caused hypertension and tachycardia which increased with the dos ... | 1977 | 189230 |
| [electrographic manifestations of sleep in the neuronally-isolated cat cortex]. | electrographic manifestations of sleep were studied in the neuronally isolated cortex prepared after khananashvili (1961). development of electrographic sleep-waking manifestations in the neuronally isolated cortex depended on the time passed after cortex isolation. during the first weeks they were not clear, but after 4-6 months it was possible to record all the sleep-waking stages characteristic of the normal animals. during different sleep-waking stages the electrical manifestations in the ne ... | 1976 | 189240 |
| [influence of sympathetic fiber stimulation on conduction of excitation in the cat pterygopalatine ganglion]. | interaction between excitation passing through parasympathetic and sympathetic pathways was studied by recording of action potentials evoked in postganglionic nerves of the cat pterygopalatine ganglion by both testing stimuli applied to the greater superficial petrosal nerve and conditioning stimuli applied to cervical sympathetic nerve. depression of synaptic transmission through the ganglion is shown to take place under stimulation of the cervical sympathetic nerve. the magnitude of such inhi ... | 1976 | 189241 |
| changes in the respiratory cycle associated with sleep. | | 1976 | 189378 |
| on the mechanism of the depressor reaction upon afferent vagal stimulation in cats. ii. role of the beta-adrenergic structures for the development of the depressor reaction. | electrical stimulation of the central section of the cervical vagus in cats with bilateral vagotomy results in lowering of the arterial blood pressure. a study is made of the effect of some beta-adrenotropic drugs on the depressor reaction. propranolol (3 mg/kg i.v.) causes considerable blocking of the depressor reaction in all experiments. on the other hand, isoprenaline ( a. 10 mug/kh/min) results in a considerable increase of this reaction. the administration of propranolol (3 mg/kg) and phen ... | 1976 | 189570 |
| eeg-studies on the phases of sleep and wakefulness after bilateral labyrinth destruction. | the dynamics of the state of wakefulness, slow and paradoxical sleep after labyrinth destruction was studied in chronic cats. the states were assessed according to the behaviour, eeg, myogram and eye movements. the labyrinth destruction was combined (chemical and mechanical). bilateral labyrinth deafferentation results in a decrease in the duration of wakefulness from 30 to 17 per cent, p less than 0.001. at the same time paradoxical sleep increased from 4 to 8 per cent, p less than 0.001. this ... | 1976 | 189572 |
| correlation between the redox state, electrical activity and blood flow in cat brain cortex during hemorrhagic shock. | | 1976 | 189584 |
| influence of mannitol on contractile responses of isolated perfused arteries. | the influence of hyperosmotic mannitol on vascular smooth muscle contractile responses was examined in isolated arterial preparations. vasoconstrictor effects of norepinephrine (ne) and potassium chloride (k+) in the perfused central artery of the rabbit's ear and in perfused mesenteric arteries of cats were significantly inhibited by infusion with krebs bicarbonate solution made hyperosmotic with mannitol (50-200 mosm increase). similarly, the magnitude and duration of vasoconstrictor responses ... | 1977 | 189621 |
| isolation of feline leukemia virus from clinical specimens. | specimens obtained from feline leukemia virus (felv)-positive cats were examined for infectious felv. feline leukemia virus was detected by a focus-forming assay and confirmed by florescent antibody. techniques of sample processing were evaluated and adjusted for optimum detection of felv. low levels of felv were detected in 2 of 10 oral samples; however, the majority of these samples (17 of 27 tested) produced cytopathic effects in tissue culture which prevented fe lv detection. three of 24 uri ... | 1977 | 189647 |
| [changes in the electrical activity of the cerebral cortex under the combined influence of cl. perfringens type a toxin and products of cl. butyricum activity]. | a study of the changes of the electrocorticogram (ecog) and the electrocardiogram (ecg) in combined action of cl. perfringens, type a, and of the cl. butyricum broth culture filtrate showed that desynchronization of the cortical electrical activity and its subsequent depression occurred at earlier periods than in the case of isolated administration of cl. perfringens toxin. the general character of the changes in the cortical rhythmic activity remained the same as in intoxication caused by cl. b ... | 1976 | 189855 |
| pulmonary metabolism of bradykinin analogues and the contribution of angiotensin converting enzyme to bradykinin inactivation in isolated lungs. | 1 the activity and pulmonary metabolism of two peptides, 7-homo pro-bradykinin and 8-homo phe-bradykinin were studied in isolated systems. 2 both analogues were about 50-70 times less active than bradykinin on the guinea-pig ileum and 70-160 times less active on isolated strips of cat terminal ileum. 3 the action of both analogues on guinea-pig ileum was potentiated (2.5-3.0 fold) by a bradykinin potentiating peptide (bpp9a) but less so than the action of bradykinin (4-5 fold). 4 like bradykinin ... | 1977 | 189870 |
| lipids in the proximal convoluted tubule of the cat kidney and the reabsorption of cholesterol. | lipid deposits in the cat kidney are mainly located in the epithelium of the proximal tubuli contorti, particularly in the pars contorta. as the amount of fatty acids in the blood of renal arteries is higher than in renal veins, the lipid inclusions are likely to be formed in the proximal convoluted tubule. whether fat occurring in the urine has been released from the nephron epithelium and the mode of this release remains obscure. the structural equivalent of lipid extrusion into the tubules ha ... | 1977 | 189931 |
| fatal generalized feline viral rhinotracheitis in a young adult cat. | a 7-month-old cat died following a 17-day illness. necropsy findings included sharply demarcated lingual ulcers and multifocal necrotic hepatitis. intranuclear inclusions were found in the lesions, and a herpesvirus was recovered from specimens of liver and tongue. the virus was identified by neutralization with specific antiserum as feline rhinotracheitis virus. | 1977 | 190195 |
| relay cell classes in the lateral geniculate nucleus of the cat and the effects of visual deprivation. | this study presents evidence that the x- and y-cells described physiologically in the a laminae of the cat's dorsal lateral geniculate nucleus (lgn) are two morphologically distinct cell types recognizable in golgi preparations. it is shown firstly that the three cell types seen in golgi preparations of the a laminae (large and medium-sized principal cells and small interneurons-types 1,2 and 3 in the classification of guillery, '66) may be identified in 1-mum epon sections of osmicated material ... | 1977 | 190274 |
| ultrastructural studies of the dying-back process. iv. differential vulnerability of pns and cns fibers in experimental central-peripheral distal axonopathies. | a companion paper in this issue (46) described the evolution of peripheral nervous system dying-back disease of the giant axonal type in animals chronically intoxicated with the neurotoxic hexacarbons n-hexane (ch3ch2ch2ch2ch2ch3), methyl n-butyl ketone or mbk (ch3coch2ch2ch2ch3), and 2,5-hexanedione (ch3coch2ch2coch3). the present study compares the distribution and pattern of peripheral (pns) and central nervous system (cns) dying-back disease produced by these three neurotoxic hexacarbons wit ... | 1977 | 190358 |
| cyclic adenosine 3', 5'-monophosphate in cerebrospinal fluid during thermoregulation and fever. | 1. samples of cerebrospinal fluid (c.s.f.) have been taken from the cisterna magna of unanaesthetized cats, whilst rectal temperature was recorded, during exposure of the animals to various ambient temperatures and during fever induced by pyrogen. the concentration of adenosine 3', 5'-monophosphate (cyclic amp) in samples of c.s.f. has been assayed. 2. cats exposed to low ambient temperatures (-2 to +2 degrees c) for 3 h maintained body temperature by both behavioural and autonomic heat gain act ... | 1976 | 190383 |