| [biological model of accelerated senescence. ii. age-related changes in the number of developing male germ cells and sertoli cells in gonads of senescence-accelerated mice]. | it was shown that in immature three- to four-week-old mice prone to accelerated senescence (samp1 strain), the number of spermatogonia, pachytene spermatocytes, and circular spermatids exceeded that in mice resistant to accelerated senescence (samr1 strain) by more than two times. differences were found in the pattern of age-related changes in the number of meiotic and postmeiotic cells in the sexually mature samp1 and samr1 mice. in the gonads of samp1 and samr1 mice, the number of sertoli cell ... | 2016 | 11433937 |
| testing karasek's demands-control model in restructured healthcare settings: effects of job strain on staff nurses' quality of work life. | job strain among staff nurses has become an increasingly important concern in relationship to employee performance and commitment to the organization in current restructured healthcare settings. | 2001 | 11388159 |
| [specificity of sensitivity to mycocin from tilletiopsis flava bkm y-2838]. | the mycocinogenous strain tilletiopsis flava vkm y-2823 was found to possess fungicidal activity at ph 3.5-4.5, which was retained after curing the strain by eliminating the extrachromosomal genetic elements. the mycocin produced by the strain had a molecular mass of more than 10 kda and was readily inactivated by heating and treatment with protease k. this mycocin was found to be active against species of the anamorphic genus tilletiopsis. the overwhelming majority of other representatives of t ... | 2006 | 11338837 |
| epitaxial growth with elastic interaction: submonolayer island formation. | a model for island formation in submonolayer epitaxy has been studied in the presence of elastic strain by means of a monte carlo simulation. the description, based on rate equations, leads to scaling predictions for cluster statistics and diffusion rates. we generalize these predictions to include the effects of the repulsive elastic interaction. the elastic interaction is caused by the deformation of the underlying substrate and has a repulsive 1/r(3) character. to enable the efficient simulat ... | 2001 | 11308858 |
| the effects of hook pattern and kyphotic angulation on mechanical strength and apical rod strain in a long-segment posterior construct using a synthetic model. | synthetic spine models were used to compare the effects of hook pattern and kyphotic angulation on stiffness and rod strain in long-segment posterior spinal constructs. | 2001 | 11305279 |
| student satisfaction with curriculum modifications in a french dental school. | since 1994, important modifications have been implemented in the dental curriculum in france, and an additional year has been included in the dental curriculum. the 1st year has remained unchanged; it is common to both medical and dental schools and leads to a selection procedure of 1 in 10 dental students. in the new curriculum, the dental student is engaged in a 5-year programme in dental school (years 2 to 6), as opposed to 4 years in the former programme (years 2 to 5). basically, this new c ... | 2000 | 11168473 |
| job strain, type a behavior pattern, and the prevalence of coronary atherosclerosis in japanese working men. | to examine the relation of type a behavior pattern and job strain to angiographically documented coronary stenosis. | 2000 | 11053607 |
| effect of reduced immunity on murine behaviors. | reduction of immunity in 11 mice of the cd1 strain by administration of methotrexate did not alter some reliable behaviors in the open-field (ambulation, rearing, defecation) compared with 10 matched mice injected with saline. perhaps moderate depression of immunity may not affect some characteristic behaviors. | 1999 | 10672743 |
| enhancement of experimental autoimmune encephalomyelitis severity by ultrasound emulsification of antigen/adjuvant in distinct strains of mice. | susceptibility to experimental autoimmune encephalomyelitis (eae) is associated with the major histocompatibility complex (mhc) haplotype. in this study eae could be induced in six out of ten mice of the resistant dba/2 (h-2d) strain by ultrasound emulsified antigen/adjuvant, whereas none of the mice immunized with the conventional adjuvant developed the disease. similar results were previously obtained for the mhc identical balb/c mice. further, while only few t cells were present in the centra ... | 2000 | 10632981 |
| elasticity and fracture strain of whole blood clots. | the measurement of clot elasticity and fracture strain is carried out using a rotational rheometer with a controlled stress system. the elasticity is quantified by a shear elastic modulus and fracture strain by a critical strain (deformation) when the clot begins to break up. the results indicate a decrease of elasticity and increase of fracture strain of the clot with increasing hematocrit. moreover, the elastic modulus of the clot is not constant but increasing with deformation. | 1999 | 10517487 |
| a local, high-density, single-nucleotide polymorphism map used to clone caenorhabditis elegans cdf-1. | ras-mediated signaling is required for induction of vulval cell fates during caenorhabditis elegans development. by screening for suppressors of the multivulva phenotype caused by constitutively active let-60 ras, we identified the mutation n2527. to clone the gene affected by n2527, we developed a method for high-resolution mapping. we took advantage of the genomic dna sequence of the n2 strain by using dna sequencing to scan for single-nucleotide polymorphisms (snps) at defined genomic positio ... | 1999 | 10511554 |
| intrinsic 'soft-start' polymerisation shrinkage-kinetics in an acrylate-based resin-composite. | a resin-composite based on multi-acrylate monomers was to be evaluated for any differences in the setting shrinkage-strain kinetics relative to more conventional formulations based on di-methacrylate monomers. | 1999 | 10483394 |
| stress and strain of blue and white collar workers during work and leisure time: results of psychophysiological and behavioral monitoring. | this study of 29 blue and 57 white collar workers (mean age 50 and 51 yr) investigated behavior and the level of subjective stress and objective strain during work and leisure time. physiological and psychological parameters as well as behavioral activities were assessed simultaneously using a special ambulatory monitoring device capable of storing 23 h records. total strain was operationalized by heart rate (hr), physical strain by physical activity, emotional strain by non-metabolic hr, and me ... | 1999 | 10416847 |
| a randomized controlled trial of day hospital and day centre therapy. | to compare the outcome of day hospital to day centre rehabilitation. | 1999 | 10348390 |
| prevention of pelvic stress fractures in female army recruits. | in 1991-1992, a pelvic stress fracture incidence of 11.2% was recorded in a cohort of 143 female australian army recruits. an incidence of 0.1% was recorded in a cohort of male recruits trained in the 1992-1993 year using a nearly identical program. a number of preventive strategies were instituted in an attempt to reduce the high incidence of injury in female recruits. route march speed was reduced from 7.5 to 5 km/h, running occurred on softer surfaces, individual step length was promoted inst ... | 1999 | 10332180 |
| [psychiatric emergencies from the viewpoint of the emergency physician]. | in the german physician-based emergency medical system (ems) psychiatric emergency situations (pes) rank on third place contradictory to it's importance during emergency physician training program. the aim of our study was to examine the relevance of pes and the stress which pes imposes upon ems physicians. further, the interest of training programs on that issue was determined. knowledge about pes was investigated by a short test. | 1998 | 9740933 |
| [significance of measuring urinary 17-ketosteroid sulfates at the work-place]. | we examined availability of urinary 17-ks-s to evaluate work and job strain by presented the results in two field research and one experiment. it became clear that urinary s/oh was a comprehensive parameter of thermal strain, under the combined load condition of temperature and exercise, and as an additional factor, under the various load conditions of air velocity. significant changes of urinary s/oh before and after the rest break and holiday suggested that the findings reflected fatigue condi ... | 1998 | 9691764 |
| living with a person who has parkinson's disease: the spouse's perspective by stage of disease. parkinson's study group. | the objective of this study was to examine the experience of spouses caregiving for their spouse with parkinson's disease (pd) and to determine whether their experiences differed by stage of disease. by using a cross-sectional design and mail questionnaire data from 380 spouse caregivers across 23 sites of the parkinson study group, key caregiver variables were examined by stage of pd. three categories of variables--caregiver role strain (10 measures), caregiver situation (four measures), and ca ... | 1998 | 9452321 |
| the buffering effect of a computer support network on caregiver strain. | computerlink was a computer support network for family caregivers of people with alzheimer's disease. in a 12-month experiment, 102 caregivers were randomly assigned to an experimental group that had access to computerlink or to a control group that did not. this investigation examined whether caregivers in the experimental group had greater reductions in four types of care-related strain by the end of the 1-year study. computerlink reduced certain types of strain if caregivers also had larger i ... | 1998 | 10182416 |
| [knee joint arthrosis of the miner--an occupational disease. on the double etiology of gonarthrosis of the miner]. | the etiology of the osteoarthrosis is a multifactorial causality. some factors, the preosteoarthrotic deformities, which concur with the recovery, are well known. the factors of the primary osteoarthrosis are still in the dark and require research. it is presented, that by the miner, the co-operation of several preosteoarthrotic deformities, especially the preosteoarthrotic deformity "repeated knee microtrauma" with unknown factors, leads to the high rate of knee wear and tear which makes the os ... | 1997 | 9173644 |
| prevention of heat strain by immersing the hands and forearms in water. | the effectiveness of hand immersion in water at 10 degrees c, 20 degrees c and 30 degrees c as a technique for reducing heat strain in royal navy (rn) personnel has been investigated at the institute of naval medicine (inm). four subjects exercised at a moderate work rate, whilst wearing fire fighting clothing in an environmental chamber at 40 degrees c. the subjects reached heat strain safety limits within 45 minutes of commencing work at which point they rested in the heat for 30 minutes whils ... | 1997 | 9282438 |
| the effect of beak trimming on two strains of commercial tom turkeys. 2. behavior traits. | the influence of beak trimming of two strains of commercial male turkeys (strains a and b) on behavior during the growing period was investigated. poults were either left with beaks intact or arc beak trimmed at hatching. strain by beak treatment interactions were generally lacking, indicating that these two strains responded similarly. beak trimming did not influence tameness (as measured by response to a novel object at 16 wk), fearfulness (as measured by tonic immobility response at 18 wk), o ... | 1996 | 9000268 |
| salient degradation features of a 50:50 pla/pga scaffold for tissue engineering. | an implant system that undergoes a gradual, time-dependent, nontoxic degradation process may offer an efficacious, safe, and desirable alternative to metallic materials used in the treatment of various musculoskeletal conditions. such a scaffold may also be a suitable vehicle for growing cells and tissue in the laboratory for tissue engineering applications. we have used a scaffold of this type previously in animal studies for biological resurfacing of large articular cartilage defects.(1) this ... | 1996 | 19877942 |
| transgenes encoding both type i and type iv c-abl proteins rescue the lethality of c-abl mutant mice. | mice carrying homozygous mutations in the c-abl gene (abl-(m1) or abl2) exhibit severe, though variable phenotypes, including a high rate of postnatal mortality, runting, morphological abnormalities, a susceptibility to infections, and selected immune system defects. to further determine the role of the c-abl protein in vivo, we have generated three lines of mice expressing c-abl transgenes. these minigenes encode the two major forms of the c-abl gene product (c-abl types i and iv) and a kinase ... | 1996 | 8700526 |
| comparative growth and development of nicholas and hybrid toms from 16 to 82 days and effects of protein restriction from 0 to 59 days on growth of hybrid toms through 125 days of age. | the objective of this experiment was to study age and diet effects on serial growth of economically important carcass parts of nicholas (nic) and hybrid (hyb) toms. at approximately 14-d intervals from 16 to 82 d, bw and the weight of selected carcass parts were compared in toms from both commercial strains. there were no overall strain differences in bw, although nic toms were heavier from 31 to 72 d, which resulted in a significant strain by age interaction (p < or = 0.021). the absolute weigh ... | 1996 | 8737846 |
| a c3h strain-specific allele (alpha va126) of the murine alpha-globin gene newly detected by ut-page and rt-pcr-sscp analysis. | an extra band. distinct from the well-characterized globin chains (alpha, beta-maj, beta-min, beta-s), was detected in an adult erythrocyte sample of the c3h strain by urea triton polyacrylamide gel electrophoresis (ut-page) analysis. the extra band was recognized by an antibody against the alpha-globin chain by western blot analysis. reverse transcription, polymerase chain reaction and single strand conformation polymorphism (rt-pcr-sscp) analysis and direct sequencing analysis of cdna of the a ... | 1996 | 8622706 |
| evaluation of mental strain by palm sweating during short-term memory task. | this paper reports on the investigation of palm sweating during short-term memory tasks and testing the availability of the amount of palm sweating for an index evaluating mental strain. six male subjects performed sets of thirty tasks with digit strings ranging from 4 to 9 digits at random order. the correctness of recalled answer, subjective difficulty for mental stress and palm sweating at each task were recorded. the amount of palm sweating (ps) was measured using hygrometry with a ventilate ... | 1996 | 8739759 |
| stress in mental health professionals: a theoretical overview. | clearly, mental health professionals are subjected to similar organizational stressors as other workers. they also face additional emotional strain by the very nature of their professions in dealing with troubled persons often over extended periods of time. further understanding of these problems and development strategies, such as insight-oriented training, requires a greater appreciation of the interactions between home-work and the individual. this broader-based ongoing research is imperative ... | 1996 | 8811392 |
| fk506 completely inhibits adriamycin efflux in the adriamycin-resistant strain of ehrlich ascites tumor cells. | adriamycin (adr) is frequently used in the clinical treatment of cancer. adr resistance is one of the most serious problems in cancer chemotherapy. several factors have been demonstrated to be related to adr resistance. among these factors, the influx of adr into cells and the efflux of adr out of cells are important aspects of its effectiveness. in this study, we investigated the influence of fk506 on the adr accumulation and retention in the adr-resistant strain of ehrlich tumor cells. the adr ... | 2013 | 8615615 |
| determination of internal strain by optical measurements. | | 1995 | 9977990 |
| skewed vh and v kappa gene family expression and pairing occurs among b lymphocytes in autoimmune motheaten mice. | motheaten mice homozygous for the recessive mev mutation develop a fatal immunodeficiency syndrome associated with hypergammaglobulinemia, thymic aplasia, production of autoantibodies and development of a severe lupus like systemic autoimmune disease. most b lymphocytes in this mutant strain belong to b-1 subset. we have addressed the question if differences existed in the v-gene repertoire of autoimmune mev/mev mice as compared to phenotypically normal mev/+ and c57bl/6 background strain by exa ... | 1995 | 8822276 |
| a malathion resistance gene associated with increased life span of the rusty grain beetle, cryptolestes ferrugineus (coleoptera: cucujidae). | the life span of the rusty grain beetle, cryptolestes ferrugineus, was determined at 30 degrees c, 75% relative humidity (rh) for virgin and mated adults of a malathion-resistant strain (bc6rr), a malathion-susceptible strain (ss), the f1 progeny of a cross between resistant females and susceptible males (rs), and an outbred strain (gv). the bc6rr strain was derived from the ss strain by incorporating the malathion resistance gene into the susceptible genome with six backcrosses and recovery of ... | 1995 | 7814781 |
| the influence of a diagnosed mental impairment on family caregiver strain. | this study examines whether a diagnosis of mental impairment of a care recipient influences the strain of family caregiving. two competing hypotheses, derived from labeling theory, provide alternative views. one posits that a diagnosis reduces strain by linking problematic characteristics of care recipients' impairment to an illness. the competing hypothesis suggests that a diagnosis increases strain by reifying the existence of a progressive chronic condition. lisrel analysis with data from a s ... | 1994 | 8169349 |
| differences between three rat strains in sensitivity to prepulse inhibition of an acoustic startle response: influence of apomorphine and phencyclidine pretreatment. | in the present study we have examined the effect of varying three prepulse parameters (prepulse intensity, prepulse duration, prepulse-pulse interval) on the level of prepulse inhibition (ppi) in lister hooded, wistar and sprague-dawley rats. the results indicate that each strain showed subtle differences in sensitivity to the prepulse. for instance, sprague-dawley and lister hooded rats showed ppi to prepulses of lower saliency compared to wistar rats. optimal prepulse parameters were selected ... | 1994 | 22298581 |
| [the characteristics of the structural organization and spontaneous dna damage in the cells of 2 lymphoma l5178y lines differing in their radiosensitivity]. | nucleotide particles, resulting from mild lysis procedure, obtained from two strains of murine l5178y lymphoma cells, differing in radiosensitivity (l-r and ly-s) showed differences in the sedimentation rate and in the halo rewinding in the presence of 40 micrograms/ml ethidium bromide (eb). microgel electrophoresis of dna after an exhaustive lysis of cells (in the presence of sodium laurylsarcosine and proteinase for 20-24 h at room temperature) disclosed not only heterogeneity in dna migration ... | 1994 | 7900205 |
| genetic analysis of developmental mechanisms in hydra. xxi. enhancement of regeneration in a regeneration-deficient mutant strain by the elimination of the interstitial cell lineage. | the interstitial cell lineage, including interstitial stem cells, nerve cells, and nematocytes, was eliminated from a regeneration-deficient mutant strain (reg-16) of hydra magnipapillata. the resultant interstitial cell lineage-free (or "epithelial") reg-16 animals showed a marked enhancement in the ability to regenerate head structures. the epithelial reg-16 polyps regenerated nearly the same number of tentacles as was originally present within 8 days after head removal, while interstitial cel ... | 1993 | 8224549 |
| potentiation and antagonism of 2,3,7,8-tetrachlorodibenzo-p-dioxin effects in a complex environmental mixture. | there is increasing need to understand the toxicity of complex environmental mixtures. the organic phase of a leachate (opl) from the love canal chemical dump site is a complex mixture that contains over 100 organic compounds, including 0.74 ppm 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd). mice congenic at the ah locus were used to evaluate several toxic effects of the opl, including immune function and hepatic enzyme induction. opl toxicity was compared with that of pure tcdd in both c57bl/6j ah ... | 1993 | 8480332 |
| correlates of caregiver strain in home health care. | family caregivers (n = 183) caring for persons admitted to home health care agencies in washington state were interviewed regarding their perceived caregiver strain. perceived subjective strain was found to be significantly related to factors beyond home health care agency control such as age of the caregiver, sex of the care receiver, and the caregiver's health. objective strain, however, was significantly related to factors such as the care receiver's functional status, types of tasks with whi ... | 1993 | 10133722 |
| significance of ventricular arrhythmias in systemic hypertension with left ventricular hypertrophy. | hypertensive patients with the electrocardiographic (ecg) pattern of left ventricular (lv) hypertrophy and strain are at increased risk of sudden death. it has been suggested that ventricular arrhythmias may be responsible. the prevalence and significance of ventricular arrhythmias was therefore studied in 90 hypertensive patients with lv hypertrophy and strain by undertaking 48-hour ambulatory ecg monitoring, ecg signal-averaging and programmed ventricular stimulation. complex ventricular ectop ... | 1992 | 1532285 |
| [osteoporotic fractures of the spine in elderly women. risk factors, inducing factors and course]. | forty-seven women with osteoporotic fractures of the spine were examined consecutively. the age range was 64-91 years with a median of 77 years. risk factors for osteoporosis such as induced menopause or gastric resection were not present. four patients had had rheumatoid arthritis. 19% had been treated with glucocorticoid. only one patient had received long-term oestrogen treatment. the patients had been physically very active at a younger age and 91% had been occupationally employed. the sympt ... | 1992 | 1539391 |
| inactivation of wild-type and rad mutant caenorhabditis elegans by 8-methoxypsoralen and near ultraviolet radiation. | survival of wild-type and four radiation-sensitive (rad) mutants of the nematode caenorhabditis elegans was determined after near-uv irradiation in the presence of 8-methoxypsoralen (8-mop). three sets of inactivation profiles were generated for each strain by irradiating synchronous populations of either early embryos, late embryos or first-stage larvae (l1s). late embryos were consistently the most sensitive. curiously, none of the four rad mutants were even moderately hypersensitive. split-do ... | 1992 | 1603841 |
| [perceived exertion during simulated static work]. | the purpose of this study was to determine the effect of static work on the rating of perceived exertion (rpe). the subject were healthy, relatively fit young adults (16 men). exercise was performed at 25% mvc both in a commonly-used work posture and in a non-typical working posture (overhead-work). estimates of effort were recorded using the cr-20-scale by borg. a nonparametric analysis was carried out to examine the relationship between the level of static load and rpe. the results show that t ... | 1991 | 2028676 |
| thy 1 expression in the brain of nude mice. | the expression and cell distribution of thy 1 antigen was studied in the brain of both normal and athymic (nude) young adult mice of the balb/c strain by immunochemistry. in nude animals thy 1 fluorescence was less intense and less regularly distributed in the molecular layer of the cerebellum and hippocampus. thy 1 content determined by elisa was lower by 10-16% in the cerebellum and 20-25% in the olfactory bulbs of nude mice. the total wet weight of the brain was lower by 16% than in control a ... | 1991 | 1681895 |
| [wolff's law of transformation after 100 years]. | in the introduction to the article the author briefly describes the history of the wolff's invention that under the influence of the function the bone structure is restructuring. this functional adaptation however, has not been fully clarified until these days. at present the general scheme of the fundamental adaptation mechanism has been generally adopted according to which the bone responds to the inner strain by aposition of the new bone while inactivity results in resorption. the author's ow ... | 1990 | 2091427 |
| weight and eating concerns among pre- and young adolescent boys and girls. | the emergence of weight and eating concerns in pre- and young adolescents and the relations of these concerns to daily experience and psychologic adjustment were investigated. four hundred eighty-one children from fifth to ninth grades completed a weight and eating concerns scale, a depression inventory, self-esteem and body image scales, and reported their daily experiences by the experience sampling method. girls tended to report more weight and eating concerns than boys. this discrepancy incr ... | 1990 | 2358387 |
| modification of the t cell responsiveness to synthetic peptides by substituting amino acids on agretopes. | t cell receptors, major histocompatibility complex molecules, and antigens constitute tri-molecular complexes which induce t cell activation. t cells in i-ab mice generate proliferative responses to a synthetic peptide composed of residues 43-58 of pigeon cytochrome c (p43-58) and its analogs with substitution at position 50 (50a, 50v, 50l, 50n, 50q, 50k, and 50m). however, none of these peptides stimulate t cells in i-ak mice. we substituted two residues at positions 46 and 54 of p43-58(50d), 5 ... | 1990 | 1708277 |
| [psychosocial strain among patients at a psychiatric emergency unit]. | the frequency of psychosocial strain was systematically registered concerning 330 consecutive patients in the psychiatric emergency unit in odense. psychosocial strain was found in 211 patients (63.9%). in all, 551 stressful events were reported, which corresponds 2.5 per patient. distribution of psychosocial strain by age, sex and civil status revealed no statistically significant correlation at the level of p less than 0.05, but there was a tendency towards greater strain among young persons, ... | 1989 | 2781665 |
| location of a synergistic factor in the capsule of a granulosis virus of the armyworm, pseudaletia unipuncta. | a synergistic factor (syf), which enhanced the infection of nuclear polyhedrosis viruses, was purified from capsules of a pseudaletia unipuncta granulosis virus (hawaiian strain) by immune affinity chromatography. the isolated syf consisted primarily of a protein with molecular mass 98 kda. the recovery rate depended on the alkali used to dissolve the capsules: the highest rate occurred with 0.05 m na2co3-0.05 m nacl, followed in turn with 0.02-0.05 m naoh and 0.04 m naoh-0.05 m glycine. the sol ... | 1989 | 2661696 |
| caregiver strain: toward an enlarged perspective. | this article attempts to broaden the conceptual perspective of caregiver strain by developing a generalized perspective that focuses on the demands and resources of caregiving. by extension, the perspective links caregiver strain to a typology relating caregiver strain and institutionalization. the result is intended to be a new and useful conceptualization for identifying factors that differentiate sources of caregiver strain and their consequences for both individuals and society. | 1989 | 10304337 |
| the level of z-dna in metabolically active, permeabilized mammalian cell nuclei is regulated by torsional strain. | permeabilized nuclei from mammalian cells encapsulated within agarose microbeads in an isotonic buffer are active in transcription and replication (jackson, d. a., and p. r. cook. 1985. embo (eur. mol. biol. organ.) j. 4:913-918). their dna is intact and the nuclei are accessible to macromolecules. myeloma nuclei prepared in this way were used to probe the extent of dna negative supercoiling and the effects of altering torsional strain by binding radioactively labeled monoclonal antibodies to z- ... | 1989 | 2921282 |
| induction of tolerance across major barriers using a two-step method with genetic analysis of tolerance induction. | using a murine skin allograft tolerance induction system that consists of intravenous injection of 1 x 10(8) allogeneic spleen cells followed by intraperitoneal (i.p.) injection of 200 mg/kg cyclophosphamide (cp) 2 days later, sensitivity to tolerance induction was examined across various histocompatibility (h) barriers. although each group of class i, class ii or multiminor h antigens was not by itself a prohibitively strong barrier, resistance to tolerance induction increased when the three ty ... | 1989 | 2659501 |
| in vitro evolution and preliminary characterization of a cadmium-resistant population of chlamydomonas reinhardtii. | a cadmium-tolerant population of chlamydomonas reinhardtii was derived from a cd-sensitive cell wall-deficient strain by long-term selection in liquid culture. a comparison of cd-sensitive and cd-tolerant cells revealed that cd tolerance was due to genetically determined alterations of metabolism rather than to increased efficiency of a detoxification system. | 1989 | 16347861 |
| 5-azacytidine-induced tumorous transformation and dna hypomethylation in nicotiana tissue cultures. | the phenomenon of habituation is considered in plant tissue cultures to be a real process of chemical tumorogenesis; the cultures acquire the capacity of autonomous growth in a hormone-free medium under the influence of a variety of chemical and physical agents. treatments with 5-azacytidine (azac) of in vitro cultured cells of the nicotiana glauca x n. langsdorffii nontumorous hybrid (nnt) during the culture cycle led to the induction of a habituated phenotype. the repetitive dna sequences show ... | 1989 | 2477189 |
| synthesis and biological activity of some further cyclopenta[a]phenanthrenes. | 16,17-dihydro-11-methoxy-15h-cyclopenta[a]phenanthrene was synthesized by two different routes and tested for carcinogenicity in tylers original (to) and sencar strain of mice by repeated application and initiation/promotion regime. 16,17-dihydro-11-hydroxy-15h-cyclopenta[alpha]phenanthrene was also tested for carcinogenicity in the to strain by repeated application. surprisingly with both of these compounds, which lack conjugation in ring d, one of the ingredients essential for biological activ ... | 1988 | 3409471 |
| inverse correlation between the utilization of an idiotype in specific immune responses and its representation in pre-immune "natural" antibodies. | previously we have characterized an idiotype (id) that accounts for half of all specific anti-dextran b512 (dex) antibodies in c57bl/6 mice. balb/c mice produce the same id in normal, pre-immune sera but fail to use it in antibody responses to dex, although id+ anti-dex antibodies can be induced in this strain by anti-id immunization. by limiting dilution analysis of b cell clonal precursors, we show here that the frequencies of id+ b cells are comparable in both strains, but their state of acti ... | 1988 | 2452744 |
| [clinical aspects and problems of pigeon breast and funnel chest]. | chest wall protrusion and depression deformities, also known as funnel chest and pigeon chest, are nosologically a uniform entity. our own histopathological studies revealed secondary changes, found likewise in arthroses, scolioses, aseptic osteonecroses and inflammatory processes, as well as changes found in so-called primary collagenous diseases of unknown aetiology. investigation of the collagen metabolism did not disclose differences from the normal ii-type collagen either qualitatively or q ... | 1988 | 3287794 |
| plantar fasciitis. mechanics and pathomechanics of treatment. | an excessive amount and/or a prolonged duration of pronation is the most common mechanical cause of structural strain resulting in plantar fasciitis. temporary relief of pain can be achieved by customary antiinflammatory drugs or therapy; long-term relief is achieved by adequate remedy of the aggravating pronation factors. a semirigid, custom-molded orthosis reduces excessive plantar fascial strain by supporting the first metatarsal bone and by controlling calcaneal position when in conjunction ... | 1988 | 3044618 |
| age dependent change in size distribution of blood cells in fetal and young mice. | the mean corpuscular volume (mcv) and the size distribution of circulating blood cells were determined in the fetal mice of c3h/he strain by using a new electric cell size analyser, coulter channelyzer c-256. on the 12th day of gestation, the volume of circulating blood cells was distributed between approximately 240-820 fl (mode at 470 fl), and the mcv was 534.9 +/- 30.1 fl, i. e., ten to eleven times that of adult one. on the 14th day, two types of cell population were observed; one with small ... | 1987 | 3609153 |
| sex pheromone blend discrimination by male moths frome andz strains of european corn borer. | sex pheromone behavioral responses were analyzed in a flight tunnel with european corn borer,ostrinia nubilalis (hübner), males from three distinct populations. males from a bivoltine and a univoltine biotype using a 97.8∶2.2 blend (z strains) of (z)- and (e)-11-tetradecenyl acetate were assayed with treatments containing 0, 0.5, 1, and 3% of thee isomer. males from neither population oriented in the plume to the 100%z treatment, but bivoltine males oriented and flew to the source to the other t ... | 1987 | 24301366 |
| ultrastructural localisation by protein a-gold immunocytochemistry of 5-enolpyruvylshikimic acid 3-phosphate synthase in a plant cell culture which overproduces the enzyme. | recently we have shown that cultured cells of the higher plant corydalis sempervirens pers., adapted to growth in the presence of high concentrations of the herbicide glyphosate, a potent specific inhibitor of the shikimate pathway enzyme 5-enolpyruvylshikimic acid 3-phosphate (epsp) synthase (ec 2.5.1.19, 3-phosphoshikimate 1-carboxyvinyltransferase) oversynthesize the epsp synthase protein (smart et al., 1985, j. biol. chem. 260, 16338-16346). we now report that the epsp synthase protein can b ... | 1987 | 24232834 |
| [accommodation and visual evoked potential during eye strain by experimental visual load]. | | 1986 | 3799377 |
| erythrocyte protein conjugates as a principle of biological monitoring for pesticides. | the determination of erythrocyte protein conjugates is recommended for monitoring worker's exposure to reactive pesticides or group of pesticides. under the assumption that reversible and especially irreversible toxic effects of these substances occur in parallel to the formation of erythrocyte adducts, the determination of the amount of adduct can be seen as a parameter for monitoring stress and strain by these substances. the application of this method is demonstrated in some practical example ... | 1986 | 3775814 |
| acetolysis of pichia pastoris ifo 0948 strain mannan containing alpha-1,2 and beta-1,2 linkages using acetolysis medium of low sulfuric acid concentration. | to obtain manno-oligosaccharides containing beta-1,2-linked nonreducing terminal groups from the mannan of pichia pastoris ifo 0948 strain by acetolysis, an attempt was made to establish the reaction conditions under which cleavage of the alpha-1,6 linkage took place preferentially leaving manno-oligosaccharides composed largely of beta-1,2 linkages. by the action of an ordinary acetolysis medium, a 10/10/1 (v/v) mixture of acetic anhydride, acetic acid, and sulfuric acid at 40 degrees c for 13 ... | 1986 | 3754107 |
| computational statistics for cell survival curves. i. evaluation of the colony-forming ability of a single cell strain by the apl function cfaline. | an interactive program for the statistical analysis of cell survival curves by a linear regression approach is described. it allows for the computational determination of the linear part of a cell survival curve and the determination of a common slope estimate in the presence of repeated experiments for a particular cell strain with the appropriate variance estimates and confidence intervals. | 1985 | 3852713 |
| the effect of improved workplace design on the development of work-related musculo-skeletal illnesses. | an earlier paper (westgaard and aaras, 1984) described the work environment and the health situation of production workers at a small norwegian factory, prior to an extensive ergonomics effort which primarily aimed to reduce static muscle strain by constructing new workplaces. it was concluded that the old work situation significantly contributed to a high level it musculo-skeletal disorders, most likely because the old work situation made it necessary to work with high level of muscle load for ... | 1985 | 15676537 |
| bony mass associated with hypertrophy of the sternohyoid muscle after radical neck dissection. | as a late complication after radical neck dissection, this paper reports a bony mass at the sternal end of the clavicle associated with hypertrophy of the sternohyoid muscle. the bony mass and hypertrophy of the muscle were considered due to continuous mechanical strain by the drooping of the shoulder caused by injury of the accessory and cervical nerves, left-handed physical labour, and the lack of the sternocleidomastoid muscle in rotating the head. | 1985 | 3921485 |
| structure and rearrangements of rrna genes in chloroplast dna in two strains of euglena gracilis. | the organisation of the rrna genes in the chloroplast genomes of two strains of euglena gracilis were analyzed and compared. it was previously shown that the bacillaris strain contains three complete rrn (rrna) operons (7) and that the z-s strain contains one operon (21). using heteroduplex analysis it was found that the bacillaris strain contains, apart from the three complete rrn operons, an extra 16s rrna gene, an extra partial 23s rrna gene sequence and an inverted duplication of a stretch w ... | 1984 | 24310346 |
| the effect of spermine on spontaneous and uv-induced mutations in schizosaccharomyces pombe. | the effect of different concentrations of spermine on spontaneous and uv-induced mutation in the adenine forward mutation system of schizosaccharomyces pombe was investigated. the effect of spermine on spontaneous mutation was studied in 5 mutator strains (mut 1-4, mut 1-23, mut 2-9, mut 2-20 and mut 3-21) and on uv-induced mutation in a pigmented adenine-requiring strain and its radiation-sensitive derivative (rad 13). the effect of spermine exposure on mutation induction before and after uv ir ... | 1984 | 6700607 |
| mechanical modeling of the stress adaptation process in bone. | the philosophy, techniques, and concepts involved in the mechanical modeling of the process of stress adaptation in bone are described here. first, the idea of a control surface, across which all mechanical forces and fluid transport are monitored, is introduced and employed to totally enclose a living whole bone. then the mechanical forces are related to local tissue stresses and the fluid transport to the local microcirculation. the concepts of strain, stress, and elasticity are introduced nex ... | 1984 | 6430529 |
| h-2 gene control of resistance to p815-x2 mastocytoma. | some, but not all, mutations at h-2 loci can alter, in either direction, histocompatible tumor resistance in the model system of p815-x2 mastocytoma (dba/2 origin) transplanted into dba/2j or (c57bl/6 x dba/2j)f1 mice. this hybrid effect has been shown previously to depend on the immune system. we have examined eight mutants at h-2kb (bm1, bm4, bm6, bm7, bm8, bm10, bm11, and bm16, two at h-2db (bm13 and bm14), and one i-ab mutant (bm12). when one parent is an h-2b mutant (c57bl/6 mutant), the hy ... | 1983 | 6640527 |
| [reduction of local muscle strain by designing a pneumatic drill for assembly work]. | | 1983 | 6649951 |
| synthesis and carcinogenic activity of oxidized benzacridines: potential metabolites of the strong carcinogen 7-methylbenz[c]acridine and of the inactive isomer 12-methylbenz[a]acridine. | the synthesis of 15 compounds related either to the benz[c]acridine or to the benz[a]acridine series is reported. spectral data, i.e., nmr and ei fragmentation, are given. these compounds were tested for carcinogenic activity in mice of the xviinc/z strain by subcutaneous injection. only three weak carcinogens were detected, 5,6-dihydro-5,6-dihydroxy-12-methylbenz[a]acridine, 3-methoxy-7-methylbenz[c]acridine, and 4-acetoxy-7-methylbenz[c]acridine. these results are discussed with consideration ... | 1983 | 6827550 |
| control of early embryonic heart morphogenesis: a hypothesis. | the early events of looping (rotation and bending) of the embryonic vertebrate heart are deformations. the deformative forces and their regulation are intrinsic to the heart. a model of cardiac morphogenesis is described in this paper. it is proposed that synthesis of extracellular matrix by the myocardium generates an internal pressure. this pressure acts as a deforming force on the myocardium which controls strain by regulating compliance. this model provides an explanation of cardiac morphoge ... | 1983 | 6557899 |
| stress relaxation and creep behaviour of normal and carbon fibre reinforced acrylic bone cement. | room temperature compression creep and stress relaxation behaviour of normal as well as carbon fibre reinforced bone cement was studied and their properties compared. it was observed that increased deformation due to creep in 24 h was about 70% of the initial strain (due to applied constant stress fo 10.5 mn/m2) for normal pmma and this could be reduced to 45% of the initial strain by carbon fibre reinforcement. surgical grade pmma, when subjected to 1% constant strain, showed an average stress- ... | 1982 | 7082743 |
| [ergonomic strain measurement in text processing]. | text processing task demands are analysed by using an ergonomic job description questionnaire. the tasks are classified by cluster analysis. tasks out of each cluster are examined with respect to performance and physiological strain by 8-h measurements. these reactions are assessed in terms of tolerance limits and the distribution of demands is discussed for non-tolerable work conditions. | 1982 | 7129650 |
| strain dependent effects of the enkephalin analogue fk 33-824 on locomotor activity in mice. | administration of the enkephalin analogue fk 33-824 was followed in the dba/2 (dba) strain by dose related depressant effects which, after the injection of 40 mg/kg, were still present 6 hrs after treatment; on the contrary, in the c57bl/6 (c57) strain, activity levels were enhanced by treatment, except for the dose of 40 mg/kg, which induced a short lasting behavioral stimulation followed by activity depression and catatonia and later on again by behavioral stimulation. all the effects of fk we ... | 1981 | 7312909 |
| ward furniture: less strain by design. | | 1981 | 10251957 |
| evaluation of heat stress in a hot workshop by physiological measurements. | the use of physiological measurements, heart rate and oral temperature, for evaluating a heat stress situation in an industrial plant is described. in contrast to evaluation of hot jobs by environmental measurements and subjective evaluation of metabolic rate, the technique used with the wbgt criteria, evaluation of heat strain by measurements of the individual's heart rate and oral temperature is simpler, less expensive, less restrictive and more protective. a description of the technique invol ... | 1981 | 7223635 |
| [effect of carbon and nitrogen sources on pullulan biosynthesis by polyploid strains of pullularia pullulans]. | the effect of eight carbohydrates and three nitrogen sources on the activity of pullulan accumulation was studied with a haploid strain, a diploid strain and a tetraploid strain of pullularia pullulans. the rate of pullulan biosynthesis was found to be the highest in media containing glucose, sucrose and maltose. in this case, the activity of the polysaccharide synthesis in the polyploid strains exceeded that in the haploid strain by 21-80% depending on the carbon source in the medium. the pullu ... | 2015 | 7194413 |
| allogeneic marrow transplantation after total lymphoid irradiation (tli): effect of dose/fraction, thymic irradiation, delayed marrow infusion, and presensitization. | balb/c mice infused with 30 x 10(6) c57bl/ka bone marrow (bm) cells 1 day after treatment with fractionated total lymphoid irradiation (tli) (17 fractions of 200 rads each) became stable mixed chimeras without clinical graft-vs-host disease (gvhd). mice given 18 fractions of 100, 50, or 25 rads each followed 1 day later by c57bl/ka bm did not become chimeric, indicating that a critical cumulative radiation dose is required for this effect. animals given tli with lead shielding placed over the th ... | 1979 | 376743 |
| the isolation and physiological analysis of mutants of the moss, physcomitrella patens, which over-produce gametophores. | several phenotypically distinct classes of gametophore overproducing mutants have been isolated in p. patens. mutants belonging to one class resemble the wild-type strain grown on medium containing a high concentration (5-50μm) of exogenously supplied cytokinin. mutants of this type can increase the production of gametophores in the wildtype strain by cross-feeding it through the culture medium. mutants belonging to another class resemble the wild-type strain cultured on medium containing a lowe ... | 1979 | 24407387 |
| induction of a tumor with greatly increased metastatic growth potential by injection of cells from a low-metastatic h-2 heterozygous tumor cell line into an h-2 incompatible parental strain. | an h-2 heterozygous sarcoma, mday, originally induced with methylcholanthrene in an (a x dba/2)f1 ((h-2a x h-2d) hybrid host was selected for growth in the h-2d homoxygous parental dba/2 strain by serial intraperitoneal transplantation of ascites tumor cells. an apparent variant, designated mday-d2, was obtained which showed the expected loss of the private and public h-2kk haplotype antigens normally associated with the a strain parent and the original mday tumor. comparison of the original and ... | 1978 | 721318 |
| [quantitative assessment of eb strain cell death in an aerosol and following rehydration]. | the authors assessed quantitatively inactivation of lyophilized cells of eb strain by the action of aerosol stress and rehydration using the method of bacterial nucleoide staining. with the advance of dust aerosol "ages" microbial sensitivity to rehydration increased and to the action of aerosol stress--decreased. the method can be used to calculate the aspiration dose in aerogenic vaccination and also to assess the efficacy of lyophilized bacteria restoration. | 1978 | 83062 |
| importance of c4a- and n5-covalent adducts in the flavin oxidation of carbanions. | the reaction of nitroalkanes, furoin, and phenacyl alcohol with 7- and 8-cyano-3,10-dimethylisoalloxazine (7-cnflox, 8-cnflox), 5-ethyl-3-methyllumiflavinium ion (flox+et), and 2.6-dichloroindophenol (dci) have been studied. nitromethane anion forms an adduct on reaction with flox +et. the condensation reaction has been shown (nuclear magnetic resonance) to occur through addition of the methylene carbon of the nitromethane anion to the 4a position of flox+et. this adduct undergoes spontaneous di ... | 1978 | 728387 |
| somatostatin: widespread abnormality in tissues of spontaneously diabetic mice. | diabetic mice of the c57bl/6j obob and c57bl/ks dbdb strains show a reduction in pancreatic somatostatin concentration accompanied in the obob strain by a striking decrease in the number of somatostatin-containing cells in the islets. somatostatin concentration is also decreased in the stomach but increased in the hypothalamus. these findings suggest different control mechanisms for somatostatin in the hypothalamus compared to the gut and pancreas and exclude a primary genetic abnormality of som ... | 1977 | 337488 |
| properties ofchlorella vulgaris strain adapted to high concentration of ammonium nitrogen. | chlorella vulgaris is very sensitive to high concentrations of ammonium nitrogen. in medium containing 0.33 g nh4-n/1 its growth is inhibited by 50%. prolonged incubation of the strain in media inhibiting any increase in cell number enabled the isolation of a strain with enhanced tolerance to high ammonium nitrogen concentration. the strain has been designated chlorella vulgaris/aa. the concentration of nitrogen inhibiting the growth of the strain by 50% was 195 g nh4-n/1. the acquired character ... | 1977 | 67767 |
| [studies on the strain on drivers during high-speed driving]. | in modern industrial countries the technological progress has shifted the occupational stress to the psychomental sphere. in the course of this alteration the number of work places with driving, controlling, and monitoring increased considerably. on 10 engine-drivers during high-speed driving from 210 to 250 km/h heart rate and electrocardiogram were monitored continuously. the blood pressure was measured intermittently. the elimination rate of catecholamines in urine, and the levels of cyclic a ... | 1976 | 184017 |
| [synovectomy in rheumatoid arthritis of the knee, radiologic investigations (author's transl)]. | pathologic and radiologic investigations of rheumatoid arthritis are compared with regard to their development. radiologic demonstration of several cases prior to and following synovectomy shows improvement as well as exacerbation of the disease. an increasing mineral content signifies an improvement of the bone lesion. the mineral content depends on reduction of inflammatory activity, increasing motility, and postoperative discontinuation of cortisone therapy. in some cases various lesions at t ... | 1976 | 1257429 |
| identification of a chloroplast ribosomal protein altered by a chloroplast mutation in chlamydomonas. | direct evidence is presented that a chloroplast gene mutation in chlamydomonas reinhardi alters one of the chloroplast ribosomal proteins. proteins of 30 s subunits of chloroplast ribosomes from mutant strains, carrying maternally inherited antibiotic resistances, were compared with those from the wild type strain by cm-cellulose column chromatography and gel electrophoresis. when 30 s ribosomal proteins from a [3h]arginine-labeled streptomycin-resistant strain and a [14c]arginine-labeled wild t ... | 1975 | 1126932 |
| [eremothecium ashbyii mutants resistant to 2,6-diaminopurine]. | 3 groups of eremothecium ashbyii mutants resistant to 5-10(-3) m 2,6-diaminopurine (dap) ahve been obtained. the mutants of the 1st group (dap-r) are selected from the initial susceptible strain by the ability to grow in the presence of 5-10(-3) m dap. the mutants of the 2nd group (azg-dap-r) are selected in the selective background of two analogues of 5-10(-3) m dap and 10(-4) m 8-azaguanine (ag). the mutants of the 3rd group (azg-r - dap-r) are isolated from the mutant azg-r 34 resistant to 10 ... | 1975 | 1240813 |
| contributions of the genes albinism (c) and retinal degeneration (rd) to a strain-by-training procedure interaction in avoidance learning. | | 1973 | 4750247 |
| [immunization of mice against a homologous strain by living virulent trypanosomes in a diffusion chamber]. | | 2013 | 5899721 |
| possible source of secondary invading staphylococci in mice exposed to acute cold. | miraglia, gennaro j. (bryn mawr college, bryn mawr, pa.) and l. joe berry. possible source of secondary invading staphylococci in mice exposed to acute cold. j. bacteriol. 85:345-348. 1963.-in an effort to determine the origin of the staphylococci known to invade the deep tissues (liver, spleen, kidneys, lungs, and heart) of mice exposed continuously to 5 c in individual compartments without bedding, the intestinal tract was freed of these organisms, as judged by absence of growth when fecal sus ... | 1963 | 16561994 |
| [induction of a transplantable tumor in mice of a swiss strain by repeated injections of chloramphenicol]. | | 1962 | 13897993 |
| [experiments in the creation of a hybrid strain by combination of various species of polymorphic trypanosoma]. | | 1955 | 13304621 |
| the relief of acute right ventricular strain by the production of an interatrial septal defect. | | 1951 | 14870261 |
| the induction of tumours in mice of the r3 strain by 2-acetylaminofluorene. | | 1947 | 20266455 |
| remedial correction of valgus foot strain by foot pronation exercise. | | 1946 | 20998926 |
| the size of the virus of rabies ("fixed" strain) by ultrafiltration analysis. | | 1936 | 20475349 |