| biochemical studies on the aqueous humour of rhesus monkeys (macaca mulatta). | aqueous humour of rhesus monkey eye contains lower concentration of glucose and excess of sodium and chloride irons in comparison to constituents of serum of the same animals. | 1975 | 1185766 |
| a simple method for obtaining blood pressure in rhesus monkeys (macaca mulatta). | a relatively simple procedure was devised to obtain blood pressures in rhesus monkeys. this procedure utilized a polygraph, pulse transducer, pressure transducer, blood pressure mixer unit, and pediatric sphygmomanometer cuff. previous attempts to auscultate the korotkoff sounds by use of a sphygmomanometer cuff and stethoscope were unsuccessful. blood pressure can be obtained by cannulation of the femoral artery, but repeated puncture may cause serious trauma to the arterial wall. this procedur ... | 1975 | 1186106 |
| a comparison of the effects of active immunization of female rhesus monkeys to estradiol-17 or progesterone-20-protein conjugates. | | 1975 | 1186239 |
| a review of total brain ischaemia models in dogs and original experiments on clamping the aorta. | dog models of total brain ischaemia for the study of pathophysiological mechanisms and post-resuscitative therapy used since 1970 are reviewed. attempts to produce isolated total cerebral ischaemia in dogs either failed to stop cerebral circulation completely because of the abundance of collateral vessels or involved complex operations with blood loss. complete airway obstruction resulted in various periods of asphyxia preceding asystole. total circulatory arrest by ventricular fibrillation for ... | 1975 | 1188189 |
| annual changes in the sexual potency of captive male rhesus monkeys. | | 1975 | 1195250 |
| evidence for a structural relationship between successive parallel tubules in the sr network and supernumerary striations of z line material in purkinje fibers of the chicken, sheep, dog and rhesus monkey heart. | the striations and the intervening filaments observed in the present study have been variously designated in the literature as: prodomal pattern, leptomeric myofibril, microladder, leptomeric organelle, leptofibril and zebra body. electron microscope examinations of purkinje fibers from the septa, papillaries, trabeculae carneae and small endocardial strands from chicken, sheep, dog and monkey hearts have revealed a close association between densely stained striations of supernumerary z line mat ... | 1975 | 1202225 |
| discrimination by rhesus monkeys of diets containing supplemental amino acids. | following an opportunity to demonstrate a preference for water with or without the addition of the amino acid isoleucine, methionine, phenylalanine, or tryptophan at a concentration proportional to that in whole egg protein, 9 monkeys were subjected on 4 occasions to a 7-day experimental week when they received an isocaloric diet containing only one-fourth the amount of protein of their normal diet. an identical low-protein diet supplemented with one of the above amino acids, again at a concentr ... | 1975 | 1215106 |
| circulating levels of steroids and chorionic gonadotropin during pregnancy in the rhesus monkey, with special attention to the rescue of the corpus luteum in early pregnancy. | | 1975 | 1222158 |
| fetectomy in monkeys (macaca mulatta): retention of the placenta past normal term. | at gestation day 65-143, fetectomy was performed in 13 monkeys (macaca mulatta), leaving the placentas in place. the uterus and abdomen were then closed, and the monkeys were subsequently observed for placental expulsion. 9 of the 13 monkeys retained the placentas past normal term. 11 placentas were recovered after spontaneous expulsion and 1 by surgery, indicating that the maternal instinct to eat the placenta was lacking in the absence of a live infant. placenta weights were near or more t ... | 1975 | 1222176 |
| cholecystokinin: a putative satiety signal. | the intestinal hormone cholecystokinin (cck) elicits satiety in rats and inhibits food intake in rhesus monkeys. this behavioral effect is specifically related to the c-terminal octapeptide structure of cck and is a new biological effect of the hormone. endogenous cck released by food entering the duodenum may inhibit feeding and elicit satiety under physiological conditions, but no experimental evidence is availabe on this point. until such evidence becomes available, we believe that cck should ... | 1975 | 1226392 |
| ultrastructural demonstration of cilia and ciliary rootlets in mammalian uterine tube epithelium in different functional states. | tissue from the infundibulum region of the uterine tube (oviduct) of guinea pigs, cattle, sheep, and swine was examined by electron microscopy. in all specimens, cilia and ciliary rootlets were present in variable numbers in the ciliated cells during both the follicular and the luteal phases of the estrous cycle. true degeneration of cilia was not evident during luteal phase or pregnancy. the ciliary rootlets in ruminant and nonruminant species had structural similarities to those described in p ... | 1975 | 1238042 |
| distribution and excretion of 3h-cyclocytidine in rhesus monkeys. | | 1975 | 1238853 |
| autopsy report on rhesus monkeys immunized with pr-beta-hcg-tt vaccine. | | 1976 | 1245128 |
| localization of function in corpus callosum: tactual information transmission in macaca mulatta. | different portions of the corpus callosum were transected in 28 juvenile rhesus monkeys. these animals were then taught a tactual roughness discrimination task while using their right hands and tested for transfer of training while using their left. animals with some part of the posterior body region of the corpus callosum preserved exhibited intermediate or high levels of transfer of training. animals with other portions of the commissures preserved, including the splenium, the anterior body, t ... | 1976 | 1252937 |
| electrophysiological studies on the cerebellocerebral projections in monkeys. | 1. responses evoked by stimulation of the cerebellar and thalamic nuclei were recorded by microelectrodes introduced at various depths in the cerebral cortex of monkeys (macaca mulatta) under light nembutal anaesthesia. 2. stimulation of the medial (fastigial) cerebellar nucleus produced, at a latency of 4-5 msec, deep thalamo-cortical (t-c) responses (surface positive-deep negative potentials) mainly in the medial part of the precentral gyrus (area 4, "motor area for hindlimb") and in the super ... | 1976 | 1253863 |
| schistosoma mansoni: reduction in clinical manifestations and in worm burdens conferred by serum and transfer factor from immune or normal rhesus monkeys. | | 1976 | 1253882 |
| adaptations of the male reproductive tract and the fate of spermatozoa following vasectomy in the rabbit, rhesus monkey, hamster and rat. | | 1976 | 1260083 |
| the effect of subdermal testosterone filled polydimethylsiloxane implants on spermatogenesis in rhesus monkeys (macaca mulata). | previously it was reported that testosterone-filled polydimethyl silicone (pds) implants induced azoospermia in male rabbits without chronically altering plasma testosterone concentration or the weight or secretory activity of accessory sex glands. assayable serum luteinizing hormone (lh) and testicular testosterone secretion were completely suppressed. testosterone emanating from the pds capsule maintained libido but failed to support spermatogeneis in the rabbits. to test results in subhuman ... | 1976 | 1261261 |
| toxicological studies on azapropazone. | the toxicity of azapropazone, a non-steroidal anti-inflammatory analgesic compound was studied in mice, rats, hamsters, guinea pigs, rabbits, cats, mongrel and beagle dogs, domestic pigs, rhesus monkeys, cynomolgus monkeys and baboons in experiments which ranged from acute, single-dose studies up to treatment periods of 1 year. the beagle dog was found to be especially sensitive to gastro-intestinal ulceration from azapropazone and this contrasted with the marked lack of gastro-intestinal hazard ... | 1976 | 1261299 |
| reproductive endocrinology of female chimpanzees: a suitable model of humans. | similarities between reproductive processes in humans and chimpanzees have led to speculation that the chimpanzee might be an excellent reproductive-endocrine model of humans. data comparing patterns and concentrations of serum gonadotropins, prolactin, and sex steroids in female humans, chimpanzees, and rhesus monkeys sustain this concept. the striking evidence that levels of estrone, estradiol, estriol, progesterone, and chorionic gonadotropin are similar during human and chimpanzee pregnancy ... | 1976 | 1263283 |
| increased fertility in rhesus monkeys by breeding after the preovulatory lh surge. | fertility in a rhesus monkey breeding colony was significantly increased by caging females with males immediately after detection of the preovulatory luteinizing hormone (lh) surge. lh was measured in daily serum samples by a rapid (24-hr) radioimmunoassay which used iodinated ovine lk as tracer and an antiserum to human lh. | 1976 | 1263429 |
| culture of schistosoma haematobium in vivo and in vitro. | the maximum rate of development of schistosoma haematobium in the hamster was determined by examination of the most advanced worms recovered at short intervals throughout the course of development. in culture s. haematobium developed at the same rate as in the hamster up to day 31 when pairing first occurs and male worms produce some spermatozoa. in vitro males formed some spermatozoa but pairing did not take place and, probably for this reason, females did not complete sexual maturation as occu ... | 1976 | 1267504 |
| progress report on the charles river breeding laboratories' free-ranging rhesus monkey breeding colony on key lois, florida. | the nucleus of a breeding colony of free-ranging rhesus monkeys (macaca mulatta) free from tuberculosis, herpes-b virus, shigellosis, and salmonellosis has been established on key lois, florida, usa. standardized procedures for trapping, quarantine, and shipping from the wild in india to the island have been established. the monkeys seem to have adapted well to the florida keys' climate. reproduction has proceeded according to expectations, and social groups have been formed with continual restr ... | 1976 | 1271747 |
| differential expression of cytochrome oxidase (cox) genes in different regions of monkey brain. | a frontal pole cdna library from monkey (macaca mulatta) brain was screened to identify mrnas that are expressed more in frontal pole as compared to primary visual cortex. three cdna clones, whose greater expression was confirmed by northern blot analysis, were identified as cytochrome oxidase (cox) subunits i, ii, and iii (cox i, ii, and iii). each clone showed higher levels of mrna in the frontal pole, dorsal lateral prefrontal cortex, and hippocampus than in the primary visual or somatosensor ... | 1992 | 1279190 |
| synthetic amyloid beta-protein fails to produce specific neurotoxicity in monkey cerebral cortex. | because progressive amyloid beta-protein (a beta p) deposition and surrounding neuritic dystrophy occur spontaneously in primates, we evaluated the in vivo effects of synthetic a beta p in monkey cortex. experimental and control a beta p were stereotactically injected into multiple neocortical sites of adult rhesus monkeys in a vehicle of either artificial cerebrospinal fluid or acetonitrile. after 2 weeks or 3 months, injection sites were identified and characterized histologically and immunocy ... | 1992 | 1281288 |
| [laser photocoagulation of experimentally produced choroidal neovascularization. 2. comparison of effects by dye and argon blue-green lasers]. | choroidal neovascularization was produced in 18 eyes of 12 rhesus monkeys by application of intense krypton laser photocoagulation. eight weeks or later, a total of 34 choroidal neovascularizations were treated either by dye laser at wavelengths of 577 or 630 nm or by argon blue-green laser. the treated lesions were evaluated clinically and histopathologically from 24 hours to 3 months after treatment. all the treated lesions were apparently healed by each of the 3 laser modalities. histopatholo ... | 1992 | 1282293 |
| postnatal development of sympathetic and sensory innervation of the rhesus monkey ovary. | we have used immunofluorescence to study the postnatal development of the sympathetic and sensory innervation to the rhesus monkey (macaca mulatta) ovary. sympathetic nerves were identified as adrenergic by their content of tyrosine hydroxylase (th)-like immunoreactivity and as peptidergic by the presence of neuropeptide y (npy). fibers containing substance p (sp) or calcitonin gene-related peptide (cgrp)-like immunoreactivity were considered as sensory, whereas vasoactive intestinal peptide (vi ... | 1992 | 1282372 |
| the effect of hyperglycemia on acid-base and sympathoadrenal responses in the hypoxemic fetal monkey. | we investigated the influence of hyperglycemia on the fetal acid-base and sympathoadrenal responses to hypoxemia (maternal fio2 9%) in rhesus monkey fetuses. in chronic preparations, we determined po2, o2 content, pco2, ph, lactate, glucose, insulin, catecholamines, heart rate, and arterial pressure. combined hyperglycemia and hypoxemia resulted in a decrease in fetal ph and an increase in lactate; however, the magnitude of these changes was only modestly, and not significantly, greater than tho ... | 1992 | 1289392 |
| pulses of oxytocin in the cerebrospinal fluid of rhesus monkeys. | cerebrospinal fluid (csf) samples were collected at frequent intervals (every 10-15 min) to determine if oxytocin pulses were present in the csf of monkeys. temporary indwelling subarachnoid catheters, with the tip of the catheter at the t12-l1 subarachnoid space, were placed in 4 nonlactating and 3 lactating (4 months post partum) female monkeys. monkeys were maintained on jacket/tether/swivel systems in a constant photoperiod (07.00-19.00 h). csf was continuously withdrawn at a rate of 1.2 ml/ ... | 1992 | 1292976 |
| effect of centchroman and tamoxifen on protein patterns of fallopian tubes of rhesus monkeys, macaca mulatta. | to study the effect of centchroman and tamoxifen on estrogen-dependent proteins of fallopian tubes of rhesus monkey, these antiestrogens were given with and without estradiol to ovariectomized monkeys. in absence of estradiol, both the compounds induced the synthesis of 130 and 95 k proteins. concentration of 85 k protein was also increased markedly. these compounds, however, suppressed the estrogen stimulated synthesis of 130 k protein when administered with estradiol. the results show that bot ... | 1992 | 1293018 |
| effect of efferentiectomy on enzymes of glycolytic pathway, hmp pathway and tca cycle in epididymis and vas deferens of rhesus monkey. | the importance of exocrine secretions of testis in the regulation of energy metabolism of the epididymis and vas deferens was examined in rhesus monkeys by performing efferentiectomy. at autopsy the epididymis was divided into initial segment, caput, corpus and cauda portions to make an account of regional differences, if any. eleven enzymes of glycolysis, two key enzymes of hmp pathway and seven enzymes of tca cycle were assayed in the epididymal segments and vas deferens of control (intact) an ... | 1992 | 1293031 |
| transmission studies with simian immunodeficiency virus of macaques; persistent infection of baboons. | the host range of sivmac was investigated in three monkey species. blood-borne and cell-adapted virus inocula obtained from a rhesus macaque infected with sivmac251 were compared. african green monkeys were not susceptible to infection, whereas baboons and rhesus macaques became persistently infected and showed similar patterns of seroconversion. however, in contrast to the macaques, no clinical or histopathological evidence of disease was seen in the baboons 2 years after virus inoculation. thu ... | 1992 | 1293067 |
| identification of pulses in hormone time series using outlier detection methods. | the identification of discrete hormonal secretory pulses is of critical importance in clinical endocrinology. pulses are defined as sudden increases in hormone concentration followed by exponential decay. we propose a model-based iterative procedure for pulse detection in pulsatile hormone time series. our model is seen to be analogous to the model for innovation outliers in autoregressive series, and outlier detection techniques for pulse identification are adapted to the endocrine context. an ... | 1992 | 1293674 |
| [effect of norepinephrine on the frontal neuron activity related to delayed discrimination task in monkeys]. | to study the role of norepinephrine (ne) in the cognitive function of the brain, the effects of ne, tolazoline (tol) and propranolol (pr) on the activity of frontal neurons were examined in 3 rhesus monkeys (macaca mulatta) during the performance of a delayed visual discrimination go/no-go task. of the 230 task-related neurons recorded from the area medial to the superior ramus of the arcuate sulcus, 159 neurons were tested with ne applied microiontophoretically. of these tested neurons, 11 neur ... | 1992 | 1293744 |
| lectin histochemical study of the prostate gland of the rhesus monkey (macaca mulatta). | glycoconjugates in the secretory epithelial cells of the rhesus monkey (macaca mulatta) prostate gland were investigated using lectin histochemistry. the monkey prostate possesses cranial and caudal lobes. histochemical staining with a battery of 8 lectins demonstrated differences in lectin binding patterns of the secretory epithelial cells between the 2 lobes. bs-1 bound exclusively to the cranial lobe, and pna bound exclusively to the caudal lobe. dba bound exclusively to a number of the secre ... | 1992 | 1294561 |
| [the humoral immunity indices of rhesus monkeys under the action of extreme factors in space flight]. | some features of nonspecific resistance of rhesus monkeys (g and a immunoglobulins and c3 complement component) are studied. standards of igg, iga and c3 complement component in healthy rhesus monkeys are determined. the changes in the parameters of nonspecific resistance of the animals in all stages of their preflight training and shortly after flight experiment are examined. these alterations were appeared first of all as an increase in iga level. | 1992 | 1296840 |
| [pharmacokinetics of epostane in rabbits by hplc method]. | epostane (epo), a 3 beta-hydroxysteroid dehydrogenase inhibitor, interrupted pregnancy in rats, rhesus monkeys, and women. epo concentrations in serum were determined by high performance liquid chromatography (hplc) at 0.25, 0.5, 1, 2, 4, 8, 16, 32, and 48 h after intragastric epo 96 mg.kg-1 in rabbits. the concentration-time curve exhibited a 2-compartment open model. the pharmacokinetic parameters were: t1/2ka 0.79 +/- 0.08 h, t1/2 alpha 0.96 +/- 0.08 h, t1/2 beta 6.6 +/- 1.5 h, vc 14 +/- 3 ml ... | 1992 | 1300055 |
| [effects of dexamethasone and cyclophosphamide on development of exo-erythrocytic form of plasmodium cynomolgi bastianellii in rhesus monkey]. | the rhesus monkeys (macaca mulatta) challenged with plasmodium cynomolgi bastianellii sporozoites were treated with im dexamethasone (dex) 1 mg.kg-1.d-1 x 7 d and cyclophosphamide (cyc) 25 mg.kg-1.d-1 x 3d, respectively. on d 7 after challenge, serial sections of liver biopsy stained with he revealed that the distributive density and size of exo-erythrocytic (ee) form of the parasites showed no difference between medicated and control monkeys. the prepatent period of the primary attack and the r ... | 1992 | 1300058 |
| [oxygenation of the frontal cerebral cortex in monkeys during a two-week space flight]. | in monkeys (macaca mulatta) during a two-week space flight and in a ground-based control experiment, with semi-closed platinum electrodes, partial oxygen pressure (po2) was registered in the frontal cerebral cortex. it was shown that during the flight there is a marked increase of po2 in the frontal cortex, reaching maximal values on days 5-8 (up to 203%) with a subsequent tendency to normalization by day 11. in the control experiment po2 values in the cortical zone studied did not exceed the ba ... | 1992 | 1301099 |
| [esophageal cancer in rhesus monkeys from the taihang mountain area. a preliminary report]. | 124 rhesus monkeys (macaca mulatta) were caught in the taihang mountain region, a high incidence area of human esophageal cancer in northern china, in january 1989. among them, two monkeys died of esophageal carcinoma in 1990. case 1, a male monkey about 6.5 years old and weighing 14.5 kg, had symptoms of salivation, vomiting and dysphagia in february 1990. the symptoms became gradually more serious and died in march 1990. postmortem examination revealed a huge tumor in the distal segment of eso ... | 1992 | 1304471 |
| comparative anatomy of the vitreous body in rhesus monkeys and man. | in the isolated unfixed vitreous body a structural organization can be visualized by slitlamp microscopy or by an ink-injection technique. we discuss the observations on human and rhesus monkey (macaca mulatta) vitreous bodies using the ink-injection technique. advantages and disadvantages of this method compared with slitlamp microscopy are described. eventual functional implications of vitreal organization are mentioned briefly. | 1992 | 1305022 |
| chronic pseudomonas aeruginosa endobronchitis in rhesus monkeys: i. effects of pentoxifylline on neutrophil influx. | host defense abnormalities in cystic fibrosis (cf) against pseudomonas aeruginosa (pa) lead to excessive neutrophil influx into the infected lungs, resulting in pulmonary complications. we have developed a rhesus monkey model of chronic pa endobronchitis by intrabronchial instillation of pa-embedded agar beads, utilizing flexible fiberoptic bronchoscopy. treatment of infected monkeys with pentoxifylline suppressed neutrophil influx and ameliorated pulmonary damage. the results suggest a method b ... | 1992 | 1307753 |
| a jejunal pouch technique in the rhesus monkey and related clinical observations. | | 1992 | 1307755 |
| detection of simian t-lymphotropic virus type i using the polymerase chain reaction. | to develop the polymerase chain reaction (pcr) for the detection of simian t-lymphotropic virus type i (stlv-i) infection, cell lines or peripheral-blood mononuclear cells (pbmc) from 2 non-human primate species [african green monkeys (agm), cercopithecus aethiops; baboon, papio cynocephalus] were evaluated for their stlv-i status using oligonucleotide primer pairs and probes specific for the tax and pol gene regions of the closely related human t-lymphotropic virus type i (htlv-i). these pcr re ... | 1992 | 1312066 |
| biology of b virus in macaque and human hosts: a review. | b virus is a zoonotic alpha-herpesvirus enzootic in asian monkeys of the genus macaca. at least 25 cases of human disease caused by b virus have occurred to date, leading to death in 16 instances. advances in the technology available for the diagnosis of b virus infection and in the agents for its treatment are improving the prognosis for cases in human beings. efforts are under way at several institutions in the united states to establish b virus-free colonies of rhesus macaques for use in biom ... | 1992 | 1313312 |
| differential influence of n-dealkylation on the stimulus properties of some opioid agonists. | the capacity of several opioid agonists and their n-dealkylated derivatives (normetabolites) to substitute for the discriminative and reinforcing stimulus properties of codeine was evaluated in rhesus monkeys, and the affinity of these compounds in binding to mu receptors in rhesus monkey brain membranes was determined. heroin (0.1 mg/kg), 6-acetylmorphine (0.1 mg/kg), methadone (0.6 mg/kg), 3-acetylmorphine (1 mg/kg), morphine (1 mg/kg) and codeine (1.8 mg/kg) substituted for the codeine cue, b ... | 1992 | 1313871 |
| high-performance liquid chromatography and preliminary pharmacokinetics of rufloxacin and its metabolites, n-desmethylrufloxacin and rufloxacinsulfoxide, in urine of rhesus monkey macaca mulatta. | a gradient high-performance liquid chromatographic method for the quantification of rufloxacin and two of its metabolites in urine, n-desmethylrufloxacin and rufloxacinsulfoxide, has been developed and validated. monkey urine samples were diluted ten times with distilled water and 20 microliters were injected onto a cp spher 5-ods column, 5 microns particle size. the mobile phase was a mixture of 4% acetonitrile and 96% buffer at time 0, which changed linearly over 37 min to 26% acetonitrile and ... | 1992 | 1314258 |
| effects of ngf and glucocorticoid on ngf receptor immunolabeling of cultured rhesus adrenal chromaffin cells. | nerve growth factor (ngf) promotes the outgrowth of neurites from cultured adrenal chromaffin cells from adult rhesus monkeys, but little is known about the distribution, at the cellular level, of the ngf receptors (ngfr) responsible for this response. we examined changes in immunostaining for ngfr in chromaffin cells cultured for 4 weeks in the presence or absence of ngf, with or without dexamethasone (dex), which inhibits neuritic outgrowth from these cells. purified cultures of adrenal chroma ... | 1992 | 1315285 |
| the effect of contraceptives containing nonoxynol-9 on the genital transmission of simian immunodeficiency virus in rhesus macaques. | the ability of two nonoxynol-9 spermicide preparations to prevent the genital transmission of siv in rhesus macaques was compared. administration of one ml of contraceptive foam before the intravaginal inoculation of cell-free siv prevented the genital transmission of siv to three of six animals, and using one ml of contraceptive gel prevented the genital transmission of siv to two of six animals. thus, both contraceptive foams and gels containing nonoxynol-9 provided protection against the geni ... | 1992 | 1315297 |
| competition between an aphakic and an occluded eye for territory in striate cortex of developing rhesus monkeys: cytochrome oxidase histochemistry in layer 4c. | monkey models were used to examine the effects of competition for cortical territory between two eyes which were deprived simultaneously, but each eye experienced a different type of deprivation. we wanted to determine whether, under this condition of binocular unequal deprivation, the postnatal process of segregation into ocular dominance columns proceeds according to the same rules as those that apply to competition between a deprived and an undeprived fellow eye. our models involved surgical ... | 1992 | 1315344 |
| expression of gaba and gabaa receptors by neurons of the subplate zone in developing primate occipital cortex: evidence for transient local circuits. | several lines of evidence suggest that the transient subplate zone of the embryonic mammalian telencephalon could influence cortical development through synaptic or trophic interactions with growing cortical afferents and migrating neurons. since such interactions may involve neurotransmitters and their receptor molecules, we have examined the expression of gaba and subunits of the gabaa/benzodiazepine receptor complex in the occipital lobe of embryonic rhesus monkeys by immunochemistry and in s ... | 1992 | 1315345 |
| predominant use of a t-cell receptor v beta gene family in simian immunodeficiency virus gag-specific cytotoxic t lymphocytes in a rhesus monkey. | to explore the structural basis for aids virus recognition by cd8+ lymphocytes, we sought to determine whether there is a diverse or restricted usage of t-cell receptors (tcr) by simian immunodeficiency virus of macaques (sivmac) gag-specific cytotoxic t lymphocytes (ctl) in the rhesus monkey. six gag-specific ctl clones were independently generated from an sivmac-infected rhesus monkey. all six ctl clones recognized a single sivmac gag peptide in association with a single major histocompatibili ... | 1992 | 1316491 |
| protein of macaques against infection with simian type d retrovirus (srv-1) by immunization with recombinant vaccinia virus expressing the envelope glycoproteins of either srv-1 or mason-pfizer monkey virus (srv-3). | rhesus macaques were immunized with live vaccinia virus recombinants expressing the envelope glycoproteins (gp70 and gp22) of simian type d retrovirus (srv), serotype 1 or 3. all of the animals immunized with either the srv-1 env or the srv-3 env vaccinia virus recombinant developed neutralizing antibodies against the homologous srv. in addition, both groups developed cross-reactive antibodies and were protected against an intravenous live-virus challenge with srv-1. the four control animals imm ... | 1992 | 1316495 |
| evaluation of the preference to and behavioral effects of an enriched environment on male rhesus monkeys. | two environments were provided to laboratory rhesus monkeys to determine if the animals spent more time (for the purposes of this study, defined as the cage side preference) in an enriched cage side than an unenriched cage side. the side (right or left) of a double-wide cage in which the animal spent the most time (as determined by chi square analysis) was initially determined during baseline observations. the "nonpreferred" side was then enriched during the experimental phase of the study. the ... | 1992 | 1316507 |
| procedure for training corral-living rhesus monkeys for fecal and blood-sample collection. | | 1992 | 1316520 |
| status of oxidative stress and antioxidant defences during plasmodium knowlesi infection and chloroquine treatment in macaca mulatta. | plasmodium knowlesi (a simian malarial parasite) infection resulted in elevation of hepatic oxidative stress in monkeys. further, the antioxidant defence system of the host was also noticeably affected. the infected monkeys showed a marked increase in the levels of superoxide (o2-), lipid peroxidation (lpo), glutathione (gsh) and xanthine oxidase (xo), and decreased levels of superoxide dismutase (sod) and catalase. oral administration of chloroquine (20 mg kg body wt-1 for 3 days) to infected m ... | 1992 | 1316884 |
| pharmacologic activity of ci-977, a selective kappa opioid agonist, in rhesus monkeys. | ci-977 is a selective, nonpeptide kappa opioid agonist. in rhesus monkeys, ci-977 is a potent antinociceptive agent against thermal stimuli after i.m. administration. increasing the intensity of the nociceptive stimulus can reduce the analgesic activity of ci-977. antinociceptive activity also was seen when pd 126212, containing ci-977 as the (-)-enantiomer, was administered sublingually. naloxone antagonized the antinociceptive action of ci-977, demonstrating opiate receptor involvement in this ... | 1992 | 1318369 |
| evidence for a lentiviral etiology in an epizootic of immune deficiency and lymphoma in stump-tailed macaques (macaca arctoides). | a retrospective study determined that an epizootic of immune suppression and lymphoma in stump-tailed macaques (macaca arctoides) that began in 1976 was associated with a horizontally spread lentivirus infection. this conclusion was based on serology, epidemiology, pathology, and virus isolation. the lesions found in the stump-tailed macaques were more compatible with lesions seen in siv-infected rhesus than those seen in rhesus macaques infected with type d retroviruses. a lentivirus, isolated ... | 1992 | 1318381 |
| lytic infection of primary rhesus kidney cells by simian virus 40. | in an attempt to analyze the persistent infection of rhesus monkey cells with simian virus 40 (sv40) in vitro, as described previously (reviewed in l. c. norkin, microbiol. rev. 46, 384-425, 1982), we infected primary rhesus cell cultures (prk), derived from a sv40-free monkey colony with sv40. surprisingly, sv40 infected prk cell cultures released as much infectious virus as cultures of the permissive african green monkey kidney cell line tc7. infected prk cells exhibited typical symptoms of a ... | 1992 | 1318609 |
| novel inclusion bodies in betz cells of cortical area 4 of aged rhesus monkeys. | seven adult rhesus monkeys ranging in age from 5 to 35 years were studied in an ultrastructural investigation of cortical area 4. some betz cells of layer 5 contained a perikaryal inclusion body (ib) of a unique and characteristic ultrastructural configuration that has not previously been described. the ibs consist of a regular array of three sets of equidistant parallel sheets and are not membrane bound. the distance between the sheets measures approximately 80 nm. the three sets of sheets inte ... | 1992 | 1318643 |
| possible influence of measles virus infection of cynomolgus monkeys on the outcome of the neurovirulence test for oral poliovirus vaccine. | macaque monkeys are susceptible to measles infection which triggers temporary immuno-depression similar to the well known phenomenon in humans. it is known that feral monkeys become infected with measles virus when they are exposed to humans. since macaca mulatta and m. fascicularis are species used to assay the neurovirulence of oral poliovirus vaccine, the immunodepression caused by measles infection of the test monkeys could significantly alter the results of the neurovirulence test. the seru ... | 1992 | 1319180 |
| alpha-melanocyte-stimulating hormone antagonizes the neuroendocrine effects of corticotropin-releasing factor and interleukin-1 alpha in the primate. | alpha-melanocyte stimulating hormone (alpha-msh), a peptide derived from pomc has previously been shown to antagonize the action of exogenously administered beta-endorphin (beta-ep) on pituitary prl and lh release in the primate. in this study, we have tested the ability of alpha-msh to block some of the acute pituitary effects of crf and interleukin-1 alpha (il-1 alpha), effects which are thought in part to result from the release of endogenous beta-ep. experiments were performed in ovariectomi ... | 1992 | 1319315 |
| organization of the zona incerta in the macaque: a nissl and golgi study. | the zona incerta has been implicated in the control of the initiation of saccadic eye movements in the primate. complex interactions within the zona incerta must take place to integrate its varied inputs and to produce a coherent efferent signal in order for this function to occur. however, whether the anatomical substrates exist within the zona incerta to allow this integration to take place has not been established. the zona incerta in monkeys (macaca mulatta) was examined in frontally, horizo ... | 1992 | 1319431 |
| correlation between plasma beta-cell tropin concentrations and body weight in obese rhesus monkeys. | the fasting plasma concentration of the pituitary peptide beta-cell tropin [beta-ct, adrenocorticotropic hormone-(22-39)] was measured in 17 rhesus monkeys from a colony known to develop spontaneous obesity. the weight of the animals was 9.4-23.9 kg (12-46% body fat). plasma beta-ct concentrations were 0.03-0.84 nmol/l and were strongly correlated with body weight (p = 0.014, r = 0.584). plasma beta-ct was also correlated with plasma insulin concentration as a power function (p = 0.011, r = 0.60 ... | 1992 | 1319685 |
| inhibin production by macaque granulosa cells from pre- and periovulatory follicles: regulation by gonadotropins and prostaglandin e2. | although inhibin (in) is secreted by granulosa cells (gc) of preovulatory follicles, the major source of immunoreactive in circulating during the primate ovarian cycle is the corpus luteum. the aims of this study were (1) to investigate culture conditions for optimal in production by luteinized gc (lgc) from rhesus monkeys and (2) to compare in and progesterone (p) production by nonluteinized gc (ngc) and lgc in response to putative agonists. animals were treated for up to 9 days with human meno ... | 1992 | 1319753 |
| cold-passaged human parainfluenza type 3 viruses contain ts and non-ts mutations leading to attenuation in rhesus monkeys. | cold-passaged (cp) mutants derived from the js strain of wild type wt parainfluenza type 3 virus (piv3) are being evaluated as candidate live virus vaccines. the wt virus was serially passaged 45 times at low temperature and mutant clones with the cold-adapted (ca), temperature-sensitive (ts), and attenuation (att) phenotypes were selected following passage levels 12, 18 and 45 (cp12, cp18, and cp45). the cp45 virus was more ts than the cp12 or cp18 mutants, although all 3 mutant viruses were cl ... | 1992 | 1320790 |
| localization of cytochrome oxidase (cox) activity and cox mrna in the hippocampus and entorhinal cortex of the monkey brain: correlation with specific neuronal pathways. | cytochrome oxidase (cox) activity and cox ii mrna expression were localized in the hippocampal formation and entorhinal cortex of the rhesus monkey brain by means of enzyme histochemistry and in situ hybridization, respectively. within the hippocampal formation, the terminal field of the perforant pathway showed the highest levels of cox activity, whereas cox ii mrna was localized mainly in neuronal cell bodies. in the entorhinal cortex. cox ii mrna was detected in neuronal cell bodies of layers ... | 1992 | 1320986 |
| the organization of gabaergic neurons in the mammalian superior colliculus. | gaba is an important inhibitory neurotransmitter in the mammalian superior colliculus. as in the lateral geniculate nucleus, gaba immunoreactive neurons in sc are almost all small and are distributed throughout the structure in all mammalian species studied to date. unlike the lgn, gaba-labeled neurons in sc have a variety of morphologies. these cells have been best characterized in cat, where horizontal and two granule cell morphologies have been identified. horizontal cells give rise to one cl ... | 1992 | 1321459 |
| field trial of rhesus rotavirus or human-rhesus rotavirus reassortant vaccine of vp7 serotype 3 or 1 specificity in infants. the elmwood, panorama, and westfall pediatric groups. | orally administered live rhesus monkey rotavirus vaccine (rrv, vp7 serotype 3) and human-rhesus reassortant rotavirus vaccine (dxrrv, vp7 serotype 1) were evaluated in a placebo-controlled field trial of 223 infants 2-4 months old. both vaccines were mildly reactogenic but were generally well tolerated in the 10 days after vaccination. rrv and dxrrv were immunogenic, inducing serum antibody responses in 78% and 71% of the vaccines, respectively. efficacy of rrv vaccine was 66% (p = .01) and of d ... | 1992 | 1321858 |
| a comparison of the discriminative stimulus properties of delta 9-tetrahydrocannabinol and cp 55,940 in rats and rhesus monkeys. | cp 55,940 [(-)-cis-3-[2-hydroxy-4-(1,1-dimethylheptyl)phenyl]-trans-4-(3- hydroxypropyl)cyclohexanol] is a potent bicyclic analog of delta 9-tetrahydrocannabinol (thc) which has been used as a probe for a cannabinoid recognition site in neural tissue. in the present study, cp 55,490 was evaluated for delta 9-thc-like effects in rats and rhesus monkeys trained to discriminate delta 9-thc from vehicle. rats trained to discriminate delta 9-thc (3.0 mg/kg i.p.) from vehicle were tested with various ... | 1992 | 1323651 |
| effects of beta-carboline on fear-related behavioral and neurohormonal responses in infant rhesus monkeys. | we examined the effects of the inverse benzodiazepine agonist ethyl-beta-carboline-3-carboxylate (beta-cce) on behavioral, hormonal, and neurochemical responses in infant rhesus monkeys exposed to fearful situations. our paradigm elicits three distinct adaptive patterns of defensive behavior. from previous work, we hypothesized that behaviors induced by attachment bond disruption are predominantly mediated by opiate systems, whereas behaviors induced by the threat of attack are mediated by benzo ... | 1992 | 1324744 |
| changes in monkey horizontal semicircular canal afferent responses after spaceflight. | extracellular responses from single horizontal semicircular canal afferents in two rhesus monkeys were studied after recovery from a 14-day biosatellite (cosmos 2044) orbital spaceflight. on the 1st postflight day, the mean gain for 9 different horizontal canal afferents, tested using one or several different passive yaw rotation waveforms, was nearly twice that for 20 horizontal canal afferents similarly tested during preflight and postflight control studies. adaptation of the afferent response ... | 1992 | 1326513 |
| catabolic disposition of 3'-azido-2',3'-dideoxyuridine in hepatocytes with evidence of azido reduction being a general catabolic pathway of 3'-azido-2',3'-dideoxynucleosides. | 3'-azido-2',3'-dideoxyuridine (azddu, cs-87) is a potent inhibitor of human immunodeficiency virus replication in vitro with low bone marrow toxicity. although azddu is currently being evaluated in clinical trials, its catabolic disposition is unknown. pharmacokinetic studies in rhesus monkeys have demonstrated that a 5'-o-glucuronide is excreted in urine. the present study examined the catabolic disposition of azddu is isolated rat hepatocytes, a model for the study at the cellular level of bio ... | 1992 | 1326966 |
| opioid and non-opioid effects of novel butyrophenone analogues. | haloperidol, haloperidol propionate, and a haloperidol analogue n-3-(p-fluorobenzoyl) propyl-4-phenyl-4-propionyl-oxypiperidine (nih 10495) were evaluated in several in vitro and in vivo tests of opioid effects. haloperidol bound to opioid receptors with very low affinity and had no opioid agonist effects in the other test systems. haloperidol propionate was 10 times less potent than nih 10495 in the binding assay and in the smooth-muscle assay. both of these haloperidol analogues decreased the ... | 1992 | 1326980 |
| [experimental reconstruction on intrinsic hand muscle function by anterior interosseous nerve transference]. | the anterior interosseous nerve was transferred to the recurrent branch of the median nerve and the deep branch of the ulnar nerve respectively to restore the function of the intrinsic hand muscles. twelve rhesus monkeys were used with 24 nerves for transference and 24 for direct suturing. gross, histological, and ultrastructural observations, electrophysiological evaluation and computer-imaging analysis system were employed to assess the nerve regeneration process in 1,3,6, and 12 months after ... | 1992 | 1327458 |
| genetic analysis of simian virus 40 from brains and kidneys of macaque monkeys. | simian virus 40 (sv40) was isolated from the brains of three rhesus monkeys and the kidneys of two other rhesus monkeys with simian immunodeficiency virus-induced immunodeficiency. a striking feature of these five cases was the tissue specificity of the sv40 replication. sv40 was also isolated from the kidney of a taiwanese rock macaque with immunodeficiency probably caused by type d retrovirus infection. multiple full-length clones were derived from all six fresh sv40 isolates, and two separate ... | 1992 | 1328671 |
| mutations adjacent to the dimple of the canine parvovirus capsid structure affect sialic acid binding. | the erythrocyte receptor on rhesus macaque erythrocytes used by canine parvovirus (cpv) for binding in hemagglutination (ha) was examined. erythrocyte membrane proteins were electrophoresed and blotted to nitrocellulose and probed with [125i]-labeled cpv capsids, showing seven virus-binding proteins. treatment of erythrocytes or isolated membranes with clostridium perfringens neuraminidase virtually abolished virus binding. binding was also affected by treatment with potassium periodate and inhi ... | 1992 | 1329321 |
| endocrine profile during acquisition of free-choice alcohol drinking in rhesus monkeys; treatment with desglycinamide-(arg8)-vasopressin. | this study concerns the effect of spontaneous acquisition of alcohol drinking in rhesus monkeys on plasma levels of beta-endorphin, acth, prolactin, cortisol and testosterone. twelve monkeys had free-choice access to water and two ethanol/water solutions (1%, 2%, v/v) for 4 weeks. during the first 2 weeks, six monkeys were injected (i.m.) twice daily with 0.50 microgram/kg desglycinamide-(arg8)-vasopressin (dgavp), a neuropeptide, that has been postulated to interfere with central positive reinf ... | 1992 | 1329787 |
| scheduling of monoaminergic neurotransmitter receptor expression in the primate neocortex during postnatal development. | quantitative in vitro autoradiography was used to study the postnatal development of monoaminergic receptors (d1 and d2 dopaminergic, 5-ht1 and 5-ht2 serotonergic, and alpha 1, alpha 2, and beta noradrenergic sites) in the prefrontal, primary motor, somatosensory, and visual cortex of rhesus monkeys at birth and 1, 2, 4, 8, 12, 36, and 60 months of age. the density of all receptors studied increased rapidly within the first 2 postnatal months to levels as high as two times that recorded in the a ... | 1992 | 1330122 |
| circadian timekeeping during pregnancy: endogenous phase relationships between maternal plasma hormones and the maternal body temperature rhythm in pregnant rhesus monkeys. | nine pregnant rhesus monkeys maintained in constant low level lighting (5 lux) from 56-80 days gestation (dga) onward were studied to assess the presence or absence of circadian maternal body temperature and maternal plasma hormone variations. maternal arterial blood samples were taken every 4 h in six monkeys (105-120 dga) for 48-56 h and every 2 h in three monkeys (108-115 dga) for 60 h. maternal intraabdominal temperature was recorded continuously. cosinor analysis was used to determine circa ... | 1992 | 1330486 |
| patterns of inter- and intralaminar gabaergic connections distinguish striate (v1) and extrastriate (v2, v4) visual cortices and their functionally specialized subdivisions in the rhesus monkey. | local gabaergic connections are undoubtedly important for the operation of cerebral cortex, including the tuning of receptive field properties of visual cortical neurons. in order to begin to correlate specific configurations of gabaergic networks with particular receptive field properties, we examined the arrangement of gabaergic neurons projecting to foci in compartments of known functional specialization in striate (area v1) and extrastriate (areas v2, v4) cortices of rhesus monkeys. gabaergi ... | 1992 | 1331364 |
| development of a novel class of cyclic hexapeptide oxytocin antagonists based on a natural product. | a new structural class of cyclic hexapeptide oxytocin antagonists derived from streptomyces silvensis and typified by l-365,209 (cyclo-[l-prolyl1-d-phenylalanyl2-l- isoleucyl3-d-dehydropiperazyl4-l-dehydroperazyl5-d-(n- methyl)phenylalanyl6]) was recently reported. in this paper we further delineate the structure-activity profile for this new class by systematic study of l-365,209 analogs obtained by total synthesis. the optimal combination of cyclic amino acid ring sizes at positions 1, 4, and ... | 1992 | 1331448 |
| [the comparative action of relanium and oxytocin on higher nervous activity in lower monkeys]. | effects of relanium and oxytocin on higher nervous activity was studied in four rhesus monkeys (macaca mulatta) and two baboons (papio hamadryas). during observation of the animals in enclosure tranquilizing effect was seen only after relanium administration. under the same conditions oxytocin practically did not change the general behaviour pattern of monkeys. however, steady behavioural transformations were observed under the conditions of competitive food-procuring behaviour and during the op ... | 1992 | 1332292 |
| [chondronecrosis induced in rhesus monkeys fed with grains and water of kaschin-beck's disease endemic area]. | immature rhesus monkeys were fed with grains and/or water of kashin-beck disease (kbd) endemic area for 6 or 18 months. multifocal and zonal chondronecrosis and a series of secondary reactions following necrosis were found in articular cartilage and growth plate in most of the monkeys. these changes are very similar to the characteristics of human kbd. the results suggest that growing rhesus monkey should be the susceptible animal for reproduction of chondronecrosis model of kbd and the articula ... | 1992 | 1332818 |
| isolation of enteroviruses and adenoviruses in continuous simian cell lines. | the ability of five simian cell lines--bgm, llc-mk2, ma104, vero and bsc-1--to isolate enteroviruses and adenoviruses from faeces was assessed and compared with that of primary or secondary rhesus monkey kidney (rhmk) and hep2 cultures. for enteroviruses, llc-mk2 and bgm were best of the five lines, detecting 77% and 73% respectively of 88 strains isolated, but neither was as good as rhmk, which detected 88%. both vero and bsc-1 detected less than 50%. all cell types were good at isolating polio ... | 1992 | 1333563 |
| an attempt to eradicate herpesvirus simiae from a rhesus monkey breeding colony. | in the fall of 1987 an attempt to establish a herpesvirus simiae (b-virus)-negative rhesus monkey (macaca mulatta) breeding colony was initiated at the armstrong laboratory. a serologic testing program was used to identify all monkeys into groups that were either positive or negative to b-virus based on serologic tests. segregation of the groups allowed the creation of breeding harems that were exclusively seropositive or -negative to b-virus. animals that were serologically positive were kept i ... | 1992 | 1334170 |
| [the plasticity of the hierarchical relationships in a pair of rhesus monkeys in competitive and noncompetitive food procurement]. | | 1992 | 1335891 |
| endocrine activation mimics the adverse effects of prenatal stress on the neuromotor development of the infant primate. | pregnant female rhesus monkeys were exposed to a 2-week period of adrenocorticotropic hormone (acth) to determine whether it would affect the early neuromotor development of their fetuses in a manner similar to that observed after psychological stressors. during the first month after birth, infants were tested on two occasions with a modification of the brazelton newborn behavioral assessment scale. infants derived from acth-treated pregnancies showed early impairments in motor coordination and ... | 1992 | 1336466 |
| pharmacokinetics and metabolism of racemic 2',3'-dideoxy-5-fluoro-3'-thiacytidine in rhesus monkeys. | 2',3'-dideoxy-5-fluoro-3'-thiacytidine (ftc) is a nucleoside analog that selectively inhibits human immunodeficiency and hepatitis b viruses in vitro. in this study, the preclinical pharmacokinetics of racemic ftc in rhesus monkeys following intravenous and oral administration were characterized. the terminal half-life of ftc was independent of the route of administration and averaged 1.34 +/- 0.18 h (mean +/- standard deviation). total clearance of ftc was moderate to high, averaging 1.49 +/- 0 ... | 1992 | 1336946 |
| survival of human monoclonal anti-rho (d) antibodies in the rhesus monkey. | in vivo half-life of a 125i-labeled human anti-d monoclonal antibody (mab) and that of 131i-labeled rho-gam was assessed in a rhesus monkey injected simultaneously with both reagents. the half-life of the mab was 7.9 days, compared to 17 days of rho-gam. survival of the second dose of mab, given 34 days after the first injection, was identical to that of the first dose, thus showing that the human mab did not elicit an immune response. the in vitro produced human mabs appear to be an alternative ... | 1992 | 1338470 |
| [experimental infection with hepatitis e virus in rhesus monkeys]. | an experimental model of hepatitis e was established in rhesus monkeys. four animals were inoculated with stool suspensions that obtained from patients with hepatitis e. two animals injected with pbs were taken as negative controls. after 4-6 weeks the alt of the four animals infected hev raised 3-4 times and the live biopsy showed acidophilic degeneration of hepatocytes and coagulative liver cell necrosis. acidophilic bodies were frequently observed. foci of lytic single-cell necrosis were also ... | 1992 | 1338701 |
| candid no. 1 argentine hemorrhagic fever vaccine protects against lethal junin virus challenge in rhesus macaques. | the protective efficacy of candid no. 1, a live-attenuated vaccine against argentine hemorrhagic fever (ahf), was evaluated in non-human primates. twenty rhesus macaques immunized 3 months previously with graded doses of candid no. 1 (16-127, 000 pfu), as well as 4 placebo-inoculated controls, were challenged with 4.41 log10 pfu of virulent p3790 strain junin virus. all controls developed severe clinical disease; 3 of 4 died. in contrast, all vaccinated animals were fully protected; none develop ... | 1992 | 1338783 |
| serological survey of a captive macaque colony in china for antibodies to simian type d retroviruses. | sera from 510 macaques consisting of macaca mulatta, macaca assamensis, macaca fascicularis, macaca nemestrina, and macaca arctoides were investigated for antibodies to simian aids type d retrovirus (srv) by elisa and western blot with viral antigens purified from supernatants of srv-1 infected cell cultures. of these monkeys, 104 were seropositive by elisa; only 23 were confirmed by western blot. the true positive reaction to srv was found in 15 of 463 (3.2%) m. mulatta and eight of eleven (72. ... | 1992 | 1339171 |
| [the correlation of iga-class antigliadin and antiendomysial antibodies (aga-iga--ema-iga) with the intestinal histology in celiac disease (cd)]. | the aim of this work was to establish the diagnostic and follow up value of iga-class antiendomysium (iga-ema) and iga-class antigliadin (iga-aga) antibodies in celiac disease. correlation with the intestinal histology at the different stages of the disease was evaluated, as well as its therapeutic monitoring ability. fifty six children, twenty seven girls and twenty nine boys, aged six months to twelve years old, were studied. thirty nine celiac children were all different diagnostic stages of ... | 1992 | 1341115 |
| a method for screening drugs against the liver stages of malaria using plasmodium gallinaceum and aedes mosquitos. | 1. the radical cure of human malaria caused by plasmodium vivax requires two drugs, i.e., a blood schizontocide such as chloroquine to clear the circulating parasites, and primaquine aimed at the liver stages (hyponozoites) responsible for the late relapses of this parasite. primaquine is unique as a radical curative drug but is highly toxic. the only useful model currently available for screening drugs to replace primaquine is plasmodium cynomolgi-induced malaria in rhesus monkeys. because of t ... | 1992 | 1341921 |
| plasmodium coatneyi-infected rhesus monkeys: a primate model for human cerebral malaria. | although several animal models for human cerebral malaria have been proposed in the past, none have shown pathological findings that are similar to those seen in humans. in order to develop an animal model for human cerebral malaria, we studied the pathology of brains of plasmodium coatneyi (primate malaria parasite)-infected rhesus monkeys. our study demonstrated parasitized erythrocyte (prbc) sequestration and cytoadherence of knobs on prbc to endothelial cells in cerebral microvessels of thes ... | 1992 | 1343725 |
| intrarectal challenge of macaques vaccinated with formalin-inactivated simian immunodeficiency virus. | macaques can be protected from intravenous infection with simian immunodeficiency virus (siv) by vaccination with chemically inactivated virus. however, protection against infection via a mucosal surface has not been demonstrated. we vaccinated four rhesus macaques with formalin-inactivated siv given intramuscularly. these monkeys, which had remained virus free for 10 months after intravenous challenge with siv, were given a further dose of vaccine and together with four unvaccinated controls we ... | 1992 | 1346285 |
| a method for quantitating motor deficits in a nonhuman primate following mptp-induced hemiparkinsonism and co-grafting. | this report describes a nonhuman primate model of mptp-induced hemiparkinsonism and the recovery of motor function following co-grafting of adrenal medullary tissue and peripheral nerve into the lesioned area of the brain. a rhesus monkey (macaca mulatta) trained to perform a complex, discrete-trial, operant task served as the subject. after behavioral performance on the task had stabilized and a high level of accuracy was maintained, 0.4 mg/kg mptp was infused acutely via the left carotid arter ... | 1992 | 1347018 |
| inhibition of vasopressin-sensitive camp accumulation by alpha 2-adrenoceptor agonists in collecting tubules is species dependent. | the ability of alpha 2-adrenoceptor agonists to inhibit vasopressin (vp)-stimulated camp accumulation in collecting tubules and to inhibit the antidiuretic effect of vp in rats is clearly established. however, in other species, such as the dog, alpha 2-adrenoceptor-induced inhibition of vp action has not been convincingly demonstrated. in the present study, we examined the effects of epinephrine and other alpha 2-adrenoceptor agonists on vp-stimulated camp accumulation in inner medullary collect ... | 1992 | 1348126 |
| effect of erythropoietic stress on donor hematopoietic cell expression in chimeric rhesus monkeys transplanted in utero. | we have previously reported the successful development of hematopoietic chimerism after the in utero transplantation of fetal hematopoietic stem cells (hsc) in rhesus monkeys (macaca mulatta). these animals exhibit sustained engraftment without immunosuppression or graft-versus-host disease (gvhd). to assess the functional response of the donor-derived erythropoietic population, we assayed the relative expression of donor and recipient hematopoietic progenitors in chimeric monkeys before and aft ... | 1992 | 1348981 |