| the effect of arterial po2 on relative retinal blood flow in monkeys. | the relationship of blood oxygenation to retinal blood flow has been studies in rhesus monkeys. constriction of major retinal arteries and veins during hyperoxia and dilation during hypoxia are demonstrated. together with mean circulation times based on the technique of fluorescein densitometry curves, these data allow an estimation of retinal blood flow, which increases considerably in hypoxia and shows a moderate decrease in hyperoxia. these findings indicate that the retinal circulation paral ... | 1975 | 1126823 |
| intramembrane organization of specialized contacts in the outer plexiform layer of the retina. a freeze-fracture study in monkeys and rabbits. | freeze-fracture analysis of the neural connections in the outer plexiform layer of the retina of primates (macaca mulatta and macaca arctoides) demonstrates a remarkable diversity in the internal structure of the synaptic membranes. in the invaginating synapses of cone pedicles, the plasma membrane of the photoreceptor ending contains an aggregate of a-face particles, a hexagonal array of synaptic vesicle sites, and rows of coated vesicle sites, which are deployed in sequence from apex to base o ... | 1975 | 1127010 |
| effects of differential removal from group on social development of rhesus monkeys. | | 1975 | 1127052 |
| on the absence of a rubrothalamic projection in the monkey with observations on some ascending mesencephalic projections. | in order to determine whether there is a rubrothalamic projection in the rhesus monkey, the ascending degeneration resulting from electrolytic lesions made in the red nucleus and adjacent mesencephalon in animals surviving at least one year after bilateral interruption of the superior cerebellar peduncles (pcs) was studied by means of the fink-heimer technique. in a necessary preliminary step it was shown that virtually all of the degeneration disappeared from the thalamus within twelve months a ... | 1975 | 1127146 |
| genetic polymorphism of properdin factor b in the rhesus: evidence for single subunit structure in primates. | properdin factor b shows genetic polymorphism in the human and the polymorphic patterns in agarose gel electrophoresis suggest a tetrameric structure. factor b polymorphism in the rhesus monkey has been demonstrated in the present study to be genetically determined and under the control of a single autosomal locus, rhesus bf. six codominant alleles, bf-f, bf-g-1, bf-g-2, bf-s-1, bf-s-2 have been recognized and the first five have been shown to have gene frequencies of 0.307,0.160,0.016,0.377, an ... | 1975 | 1127225 |
| pharmacokinetics of carbamazepine in monkeys following intravenous and oral administration. | the pharmacokinetics of carbamazepine were evaluated in four male rhesus monkeys. a 20-mg/kg dose was administered by intravenous (5-min) infusion and orally (nasal-gastric intubation) in a propylene glycol-ethanol-water solvent. plasma and urine determinations were performed by glc. all semilogarithmic intravenous curves exhibited an irregular decay behavior in the first 3-hr period, followed by a linear disappearance phase (t 1/2 equals 1.0-2.4 hr). urinary excretion measurements confirmed the ... | 1975 | 1127587 |
| mating seasonality in castrated male rhesus monkeys. | | 1975 | 1127650 |
| scanning electron microscopy of human and rhesus monkey kidneys. | human kidney biopsies fixed by immersion fixation and a rhesus monkey kidney fixed by vascular perfusion were critical point-dried and studied by scanning electron microscopy. the surface morphologies of the parietal and visceral epithelial cells and cells lining the uriniferous tubules are described. many instructive views of these cells as well as some new nephronal features are presented. this study demonstrated that both scanning and transmission electron microscopy may be undertaken on the ... | 1975 | 1127875 |
| functional anatomy of the testicular vascular pedicle in the rhesus monkey: evidence for a local testosterone concentrating mechanism (38513). | the detailed anatomy of arteries and veins in the testicular pedicle of the rhesus monkey, with special emphasis on an area of extensive surface contact between these vessels in the spermatic cord, is described. the mean plasma testosterone concentration in blood from the testicular artery was significantly greater than the mean for samples collected simultaneously from the contralateral femoral artery in 11 monkeys. these observations are interpreted as supportive of the hypothesis that a hormo ... | 1975 | 1129261 |
| localization of the antinociceptive action of morphine in primate brain. | microinjections of morphine sulfate (20-40 mu g) were made into various subcortical regions of the rhesus monkey brain. the effects of these injections were evaluated on the nociceptive threshold as defined by the shock titration technique. the results of this preliminary investigation indicate that the region of maximal antinociceptive sensitivity to morphine in the primate is the periventricular-periaqueductal gray matter. it is tentatively suggested that morphine lowers that affective tone or ... | 1975 | 1129350 |
| hemodynimic effects of systemic and central administration of clonidine in the monkey. | systemic and regional hemodynamic changes were measured in restrained, conscious rhesus monkeys with indwelling arterial and venous catheters before and after clonidine (5 and 15 mug/kg) was slowly infused intravenously or smaller doses (2 mug/kg) were injected into a lateral cerebral ventricle. dye-dilution cardiac outputs and the complete distribution of cardiac output were obtained intermittently with the use of the radioactive microsphere method. after the higher intravenous dose and the int ... | 1975 | 1130526 |
| the effect of bile acid synthesis on cholesterol secretion into the bile. | cholesterol secretion into the bile has been shown to be related to the bile acid secretion rate. it has been suggested that the availability of bile acid micelles controls the entry of cholesterol into the bile. however, previous data could have been interpreted to indicate that bile acid synthesis controls cholesterol secretion into the bile. to discover whether bile acid synthesis has a significant influence on cholesterol secretion, rhesus monkeys were studied during the period of increasin ... | 1975 | 1130865 |
| loss of cholesterol from muscle and skin of monkeys treated with nicotinic acid. | in rhesus monkeys, nicotinic acid given daily by subcutaneous injection for 5 weeks brought about a reversible decrease in total cholesterol concentration in skeletal muscle and skin to about half the normal value. the decrease in cholesterol concentration was due to a net loss of cholesterol from muscle, since the treatment had no effect on the water content or on the percentage of dna or protein in fresh tissue. in muscle, free cholesterol was lost in preference to esterified cholesteol, but i ... | 1975 | 1131307 |
| the non-teratogenicity of 2,4,5-trichlorophenoxyacetic acid in the rhesus monkey (macaca mulatta). | the herbicide 2,4,5-trichlorophenoxyacetic acid (2,4,5-t) containing 0.05 ppm of tetrachlorodibenzo-p-dioxin, was administered to pregnant rhesus monkeys daily from day 22 through day 38 of gestation. at the dose levels administered, 0.05 mg/kg, 1 mg/kg, and 10 mg/kg, no evidence of toxicity was seen in the mother and no evidence of teratogenicity was seen in any of the offspring. observations of the infants for 1 year following birth indicated that there was no toxicity due to the 2,4,5-t. | 1975 | 1131451 |
| effect of mild hypoxia on delyaed differentiation in the monkey (macaca mulatta). | | 1975 | 1132463 |
| growth and development of the fetal rhesus monkey. vi. morphometric analysis of the developing lung. | groups of fetal monkeys were studied at 50, 75, 100, 125 and 150 days gestational age, and postnatal monkeys were studied at 175 days gestational age and in adult life (full term gestation is 168 plus or minus 4 days). the ratios between the various tissues of which lung is composed were determined by light and electronmicroscopy. characteristic changes in ratios were noted at each developmental age. primitive bronchioles increased from 50 to 75 days, decreased as permanent bronchioles, alveolar ... | 1975 | 1132776 |
| long-term administration of artificial sweeteners to the rhesus monkey (m. mulatta). | | 1975 | 1132854 |
| optic nerve circulation and ocular pressure: contribution of central retinal artery and short posterior ciliary arteries and the effect on oxygen tension. | blood-flow rate in the optic nerve of the rhesus monkey 4 mm. behind the globe monitored by the heated thermocouple and tissue p02 measurement is found to be influenced by ocular pressure level. ligation of central retinal artery reduced flow rate to 79 per cent of normal but did not influence the effect of iop on blood-flow rate. ligation of short posterior ciliary arteries reduced blood-flow rate to 21 per cent of normal and virtually eliminated the iop effect. raising iop to above systolic ar ... | 1975 | 1132944 |
| the role of calcium and fluoride in osteoporosis in rhesus monkeys. | twenty-two female rhesus monkeys were fed purified diets varying in calcium and fluoride content for five years and studied, using radiographic, photon absorptiometric and histologic techniques. the results suggested that: 1) the addition of fluoride (50 ppm) to a diet containing 1 per cent calcium resulted in a reduction in bone growth rate and resorption, without affecting bone size or density nor resulting in fluorosis; 2) a diet containing 0.15 per cent calcium resulted in osteoporosis due ... | 1975 | 1132953 |
| runyon group iii atypical mycobacteria as a cause of tuberculosis in a rhesus monkey. | bilateral draining fistulas which communicated with the cheek pouches were noted in the threat region of an adult femal macaca mulatta receiving isoniazid for tuberculosis prophylaxis. necrospy findings included enlargedregional lymph nodes and ulceration of cheek pouch mucous membranes. acid-fast bacilli were demonstrated in tissue section. cultures of the regional lymph nodes and cheek pouch mucous membrane yielded runyon group iii mycobacteria. intrapalpebral tuberculin tests with homologous ... | 1975 | 1134036 |
| food rejection by female rhesus monkeys during the menstrual cycle and early pregnancy. | | 1975 | 1135321 |
| preparation and quantitation of urinary metabolites of prostaglandin f2alpha by radioimmunoassay. | radioimmunoassay systems are described which have been developed to quantitate two principle urinary metabolites of pgf2alpha; 9alpha,11alpha-dihydroxy-15-oxo-2,3,4,5-tetranorprostanoic acid (i) and 9alpha,11alpha-dihydroxy-15-oxo-2,3,4,5-tetranorprosta-1,20-dioic acid (ii). preparation of the required metabolites was achieved by total synthesis (i) or by bioconversion (isolation from urine of animals treated with 15-keto-pgf2alpha, ii). these metabolites were used to prepare conjugates for immu ... | 1975 | 1135444 |
| aflatoxicol h1: a major metabolite of aflatoxin b1 produced by human and rhesus monkey livers in vitro. | among the major metabolites of aflatoxin b1 produced by human and monkey livers in vitro is a derivative with the ketone carbonyl on the cyclopentane ring reduced to a secondary alcohol, and a hydroxyl introduced onto the carbon beta to the alcohol group. the metabolite was formed from aflatoxin b1 at a level similar to that of aflatoxin m1.both the microsomal hydroxylase and the cytoplasmic reductase systems are required for its formation. bioassay using chicken embryos and a mutant of salmonel ... | 1975 | 1135508 |
| tissue distribution of ['h]nicotine in dogs and rhesus monkeys. | | 1975 | 1135877 |
| wernicke's encephalopathy: an experimental study in the rhesus monkey. | experimental wernicke's encephalopathy, induced in rhesus monkeys with a diet lacking thiamine (vitamin b1), is characterized by cavitary necrosis of the striatum as well as a microvacuolar periventricular lesion of the brain stem such as occurs in man. with high resolution light microscopy and electron microscopy, the primary structural alteration in the brain stem lesion, and probably also in the striatum, appears to be that of widespread "blister" formation due to splitting of myelin at the i ... | 1975 | 1136712 |
| biochemical changes in the spermatozoa and luminal contents of different regions of the epididymis of the rhesus monkey, macaca mulatta. | | 1975 | 1137941 |
| influenza virus as a teratogen in rhesus monkeys. | | 1975 | 1138197 |
| a choice procedure for drug reinforcers: cocaine and methylphenidate in the rhesus monkey. | a choice procedure was developed to compare the reinforcing efficacy of drug solutions delivered via intravenous catheters to rhesus monkeys. choices were arranged between doses of cocaine or methylphenidate and saline, different doses of the same drug and doses of both drugs. in each session, monkeys were allowed to self-inject one solution five times in the presence of a stimulus. thirty minutes after the fifth injection, a second solution could be self-injected five times in the presence of a ... | 1975 | 1142112 |
| altered growth of hormone secretory pattern following prolonged sleep deprivation in the rhesus monkey. | plasma concentrations of growth hormone (gh) were determined in samples obtained sequentially at 15-min intervals during the last 4 h in monkeys deprived of sleep for 76 h and the first 8 h of ensuing recovery sleep. electroencephalographic (eeg), electro-oculographic (eog), and electromyographic (emg) activities were recorded. stages 3-4 sleep occurred rapidly after sleep onset and were of long duration. plasma gh secretion was markedly elevated during sleep recovery, without apparent relations ... | 1975 | 1143632 |
| studies on the metabolism of chloroquine in rhesus monkeys and human subjects. | | 1975 | 1145718 |
| projection of the vestibular nerve to the si arm field in the cerebral cortex of the cat. | evoked cortical focal potentials from electrical vestibular nerve stimulation were recorded in the pcd-area in cats anaesthetized with chloralose or nembutal. for comparison, additional cortical projections were located for n. rad. superficialis and group ia muscle afferents from n. rad. prof., n. fibularis prof., n. femuralis ramus muscularis and the motor nerve to the trapezoid muscle. surface positive potentials, which reversed to negativity in middle cortical layers, were for vestibular nerv ... | 1975 | 1146542 |
| movement disorders in rhesus monkeys after infection with tick-borne encephalitis virus. | | 1975 | 1146648 |
| analysis of the components of bile flow in the rhesus monkey. | bile flow studies were performed in three groups of awake rhesus monkeys. in the first group, the increase in bile flow stimulated by secretin was not accompanied by an increase in erythritol-14c clearance. resection of the gastric antrum and small intestine in the second group resulted in stable bile flow at fixed bile salt secretion rates. linear regression lines for bile flow versus bile salt secretion rate and erythritol-14c clearance versus bile salt secretion rate were parallel, and the y ... | 1975 | 1147001 |
| creatinine exchange between mother, fetus, and amniotic fluid. | creatinine exchange between mother, fetus, and amniotic fluid was investigated in rhesus monkeys in late pregnancy in which a different radioactive-labeled form of creatinine was injected simultaneously into either of two of the three possible compartments. creatinine specific activity was then determined for each isotope in each compartment over the ensuing 4-6 h. a rapid and extensive bidirectional exchange occurred between all three compartments. maternal-fetal flux, while bidirectional, see ... | 1975 | 1147015 |
| casts of chorodial vasculature at physiologic pressures. a new technique. | a method for making latex rubber casts of the ocular vasculature while maintaining physiologic vascular relations has been developed. a series of short-haired domestic ctas, rhesus monkeys, and albino rabbits were anesthetized and cannulated in the common carotid arteries. the jugular veins were severed, and heparinized saline was infused into the carotid arterial circulation of the animals for complete exsanguination of the head. throughout the infusion procedure, normal physiologic pressure wa ... | 1975 | 1147808 |
| in vivo thrombolysis. an experimental model in rhesus monkeys. | an experimental model of diffuse thromboembolism in the intrarenal circulation of the rhesus monkey was produced by intra-arterial injection of homogenised, homologous [125-i]fibrin. a sequential study of thromolysis was carried out using the conventional method of determining the thromboembolic index in the arteries of both kidneys together with radioautography and counting of radioactivity in the renal homogenate. quantitative estimation of radioactivity in the renal homogenate, as well as rad ... | 1975 | 1148031 |
| intrahemispheric cortical connexions and visual guidance of hand and finger movements in the rhusus monkey. | an attempt has been made to elucidate in the rhesus monkey the role of intrahemispheric cortico-cortical connexions in visual guidance of relatively independent hand and finger movements which are governed mainly from the precentral motor cortex. these movements were tested by requiring the animals to retrieve with their fingers small food pellets from a special test board in which the pellets were easily visible but were more difficult to palpate. unilateral occipital lobectomy combined with a ... | 1975 | 1148818 |
| the metabolic clearance rate, head and brain extractions, and brain distribution and metabolism of progesterone in the anesthetized, female monkey (macaca mulatta). | the brain distribution and metabolism of progesterone were studied in female, rhesus monkeys. adult monkeys were anesthetized with ketamine and were given a constant infusion of [3h]- or [14c] progesterone. blood samples were obtained from cannulae inserted into the carotid artery, the jugular vein and lateral (transverse) sinus. the metabolic clearance rate of progesterone was 295 +/- 49 (s.e.) 1/day. the head extraction of progesterone was 30.4 +/- 8.3% (s.e.) and the brain extraction 26.0 +/- ... | 1975 | 1148868 |
| permanent bile duct cannulation in the monkey. a model for studying intestinal absorption. | our aim has been to obtain an experimental model where the test animal is subjected to the least amount of stress and restraint, and can serve for the repeated sampling of biliary excretion over a prolonged period of time. by using a special end-piece at the outer terminals of the two cannulas the monkeys could be given full freedom after experimentation. during the course of the study it was found that insertion of the cannula into the common bile duct led to the development of collateral pathw ... | 1975 | 1149809 |
| eye and head movements evoked by electrical stimulation of monkey superior colliculus. | in unrestrained animals of many species, electrical stimulation at sites in the superior colliculus evokes motions of the head and eyes. collicular stimulation in monkeys whose heads are rigidly fixed is known to elicit a saccade whose characteristics depend on the site stimulated and are largely independent of electrical stimulation parameters and initial eye position. this study examined what role the colliculus plays in the coding of head movements. a secondary aim was to demonstrate the effe ... | 1975 | 1149845 |
| second-order schedules of drug injection. | key-press responding of squirrel monkeys produced intravenous injections of cocaine under two simple types of schedule. under a fixed ratio schedule, every 30th response produced an injection; steady responding at high rates of over one per second were maintained during each fixed-ratio component. under a fixed-interval schedule, the first response occurring after a fixed time of 5 min produced an injection; there was a pause at the start of each interval and then progressively increasing respon ... | 1975 | 1149889 |
| toxicity of chenodeoxycholic acid in the rhesus monkey. | chenodeoxycholic acid is an important drug for the treatment of cholesterol cholelithiasis in man. although no toxicity has been demostrated in man, liver lesions develop in rhesus monkeys treated with chenodeoxycholic acid. to elucidate the mechanism of toxicity, chenodeoxycholic acid. to elucidate the mechanism of toxicity, chenodeoxycholic acid was fed daily to three groups of 6 animals each at the following dose: 10, 40, and 100 mg per kg; 2 separate animals were not treated and served as co ... | 1975 | 1150041 |
| arterial and muscle oxygen tension in experimental models of asthma. experimental models of asthma. | the immediate-type airway response in anesthetized dogs and rhesus monkeys to two antigens (ascaris and keyhole limpet hemocyanin) and pharmacologic agents (histamine, methacholine and prostaglandin f2alpha) were studied. the pulmonary function abnormalities demonstrated by changes in breathing frequency, peak expiratory flow rate, pulmonary resistance, expiratory-inspiratory time ratio, tidal volume, and dynamic compliance were compared with simultaneous determinations of arterial po2, muscle p ... | 1975 | 1150331 |
| effect of ocular pressure on choroidal circulation in the cat and rhesus monkey. | using the heated thermocouple principle to monitor blood flow-rate in the choroid of the anesthetized cat and rhesus monkey revealed that elevation of ocular pressure reduces blood flow-rate in the choroidal circulation. the magnitude of this effect at varying levels of ocular pressure led to the conclusion that the vascular bed of the choroid in these experimental animals is a passive one without evidence of active regulation. | 1975 | 1150399 |
| preovulatory progestins: observation on their source in rhesus monkeys. | progesterone (p) and 20alpha-hydroxypregen-4-en-3-one (20alpha-ol)concentrations were measured in systemic and ovarian vein plasma of adult cycling female rehsus monkeys by gas liquid chromatography with electron capture detection. blood samples and ovaries were removed at various times during the intermenstrual period. the animals were then reclassified according to the stage of the ovarian cycle and the morphology of the ovary. very little p or 20alpha-ol is secreted by the ovary during the fo ... | 1975 | 1150856 |
| proceedings: effects of dexamethasone on plasma steroid concentrations and foetal adrenal histology in the pregnant rhesus monkey. | | 1975 | 1151239 |
| the acetylcholine-dopamine balance in the basal ganglia of rhesus monkeys and its role in dynamic, dystonic, dyskinetic, and epileptoid motor activities. | behavioural analyses have been made of effects brought about by both single and combined injections of dopamine, haloperidol, carbachol and atropine into the caput nuclei caudati of rhesus monkeys. high doses of dopamine produced the subsequent development of three types of behavioural changes: an increase in the number of skilled manipulation movements (the dynamic phase); the appearance of a dystonic torticollis (the dystonic phase); and, finally, the appearance of an oro-lingual-facial dyskin ... | 1975 | 1151371 |
| restitution of bile duct after ligation and excision in rhesus monkeys. | | 1975 | 1151586 |
| further studies on self-administration of antipyretic analgesics and combination of antipyretic analgesics with codeine in rhesus monkeys. | the possible reinforcing effect of acetylsalicylic acid (asa) was studied in a group of rhesus monkeys that had no history of self-administration of drugs. rates of lever pressing were compared under conditions in which each lever-pressing response resulted in an infusion of saline, an infusion of saline plus delivery of a food pellet or an infusion of asa (0.4, 1.0, 2.5 or 5.0 mg/kg /infusion). responding was engendered and maintained by the delivery of food pellets but not by infusions of sali ... | 1975 | 1151735 |
| relationship of the sarcoplasmic reticulum to fibril and triadic junction development in skeletal muscle fibers of fetal monkeys and humans. | examinations of stages of fibril development in muscle fibers of seven rhesus monkey and six human fetuses reveal sr tubules encircling the z lines at all stages of fibril development. the encircling sr tubules are continuous with the sr network of tubules which is found surrounding fibrils at all stages of development observed. the sr tubules encircling the z lines show connections (electron-opaque strands) with the z lines. the developing triadic junction shows a progressive increase in comple ... | 1975 | 1152065 |
| cast of the z-shaped cervical canal of the uterus of the rhesus monkey. | | 1975 | 1152429 |
| the choline incorporation pathway: primary mechanism for de novo lecithin synthesis in fetal primate lung. | the two pathways of de novo lecithin synthesis, choline incorporation (i) and phosphatidylethanolamine methylation (ii), were examined in lung slices from rhesus monkey fetuses throughout the last half of gestation. incorporation rates of pathway-specific radioactive precursors were used as a measure of lecithin production. at all stages of development studied, pathway i incorporated 10-50 times more precursor ([14c]choline) into lecithin than did pathway ii ([14c]methionine or [14c]ethanolamine ... | 1975 | 1153240 |
| effectiveness of prostaglandin f 2 alpha in restoration of hmg-hcg induced ovulation in indomethacin-treated rhesus monkeys. | six mature female rhesus monkeys were treated with hmg-hcg in control cycles at doses adjusted to induce ovulation while avoiding superovulation. occurrence of ovulation was determined by observation of fresh ovulation points at laparotomy 48 to 120 hours following hcg. in subsequent cycles animals were treated with indomethacin (treatment days 4 through 10) together with the established dose of hmg-hcg. in 8 cycles indomethacin 5 mg/kg was given i.m. once daily; in 9 cycles 10 mg/kg i.m. was ad ... | 1975 | 1153797 |
| the effect of indomethacin of hmg-hcg induced ovulation in the phesus monkey. | the investigation was designed to study the influence of indomethacin on gonadotropin induced ovulation in the rhesus monkey. six mature female monkeys were treated with hmg-hcg for at least 2 control ovulatory cycles at dosage levels adjusted to induced ovulation while avoiding superovulation. ovulation was confirmed by observation of the ovaries for fresh ovulation points at laparotomy. following establishment of an appropriate dosage schedule, treatment was begun with indomethacin (5 mg/kg/da ... | 1975 | 1153814 |
| comparative distribution and embryotoxicity of hydroxyurea in pregnant rats and rhesus monkeys. | hydroxyurea was given to pregnant rhesus monkeys and pregnant rats in regimens adjusted to produce similar degrees of teratogenicity, for the purpose of comparing the distribution of the drug in the females and their embryos. according, in rats 137 mg/kg/day ip on days 9-12 resulted in a drug half-life in maternal plasma of about 15 min and in embryos about 85 min, after the last injection; and in monkeys 100 mg/kg/days iv on days 23-32 resulted in drug half-life in maternal plasma estimated to ... | 1975 | 1154282 |
| teratologic evaluation of imipramine hydrochloride in bonnet (macaca radiata) and rhesus monkeys (macaca mulatta). | imipramine hydrochloride was administered orally twice daily to 18 bonnet and 3 rhesus monkeys between days 23 and 45 of pregnancy for 1-3 or 18-22 days at 1, 2, and 10 times the recommended human dose. no teratologic changes were observed, although signs of maternal toxicity occurred at the high dose level, and the abortion rate was higher than in controls. | 1975 | 1154287 |
| percutaneous absorption in the rhesus monkey compared to man. | | 1975 | 1154403 |
| vegetative innervation of the esophagus. iii. intraepithelial endings. | intraepithelial fibers do occur in the mucosa of the esophagus, as demonstrated by the osmium tetroxide-zinc iodide method in cats and rhesus monkeys. the esophagus is divided into three parts, in order to study the penetration incidence, and the uppermost and the lowest show the greatest density of penetration, while in the middle portion only occasional fibers in small numbers are found. the specific characteristics observed in this type of fiber, such as their distribution along the wall of t ... | 1975 | 1155013 |
| postnatal differentiation of "presynaptic dendrites" in the lateral geniculate nucleus of the rhesus monkey. | the most characteristic synaptic arrangement in the lgn is the triadic unit, in which a retinal terminal is presynaptic to a principal cell (p cell) and to a golgi interneuron (i cell) dendrite, which contains synaptic vesicles and is in turn presynaptic to the same p-cell element. the ontogenetic differentiation of these "presynaptic dendrites" was studied in monkey lgn by standard and quantitative electron microscopy. the dendrites and axonal arborization of i cells are well developed in the n ... | 1975 | 1155256 |
| effects of fetal decapitation on the structure and function of leydig cells in rhesus monkeys (macaca mulatta). | fetal decapitation in utero has enabled us to study the role of fetal pituitary hormones in the development of the fetal testis. testes from males decapitated near 80 days of gestational life and later delivered at 150 days were smaller than normal and about one-tenth the normal weight. the size of the seminiferous tubules was similar in both groups; however, the number of leydig cells seemed reduced. in addition, the leydig cells of the experimental group contained smaller mitochondria with red ... | 1975 | 1155361 |
| calcitonin effects in primate pregnancy. | the acute effects of calcitonin (ct), a hypocalcemic hormone to act by inhibiting bone resorption, were studied in rhesus monkeys in late pregnancy. salmon ct was injected intravenously into either mother or fetus and the concentration of total calcium and inorganic phosphorus in maternal plasma, fetal plasma, and amniotic fluid measured. maternal ct administration produced a gradual fall in maternal plasma calcium levels and, to a lesser extent, in maternal plasma phosphorus levels. both dep ... | 1975 | 1155502 |
| sequential changes in weight of the skeleton and in length of long limb bones of macaca mulatta. | in a collection of 274 monkeys (macaca mulatta) the relative weight of the dry, fat-free skeleton, expressed as a proportion of total body weight, increases significantly throughout the gestational period to approximately 6% with only random variation after birth. the weight of the fetal skeleton increases exponentially with age. in the postnatal period the skeletal weight increases asymptotically to adulthood, which is considered to be 6.5 years of age. equations for estimating skeletal weight ... | 1975 | 1155594 |
| in vivo measurement of brain glucose transport and metabolism employing glucose- -11c. | the radiopharmaceutical glucose--11c was used in vivo measurement of brain-glucose transport kinetics and metabolism in the rhesus monkey. radiotracer was injected intravenously as a bolus. radioactivity was continuously recorded from the head and from the arterial blood via an indwelling peripheral artery catheter for a collectionperiod of 2-3 min. to correct the reading obtained from the head for radioactivitycontained in blood, a second intravenous injection of the vascular tracer -15o-lab ... | 1975 | 1155625 |
| serum and aortic lipid profiles in spontaneous and cholesterol-induced atherosclerosis in rhesus monkeys. | serum lipids and lipoproteins and various lipid fractions in the aorta were compared in spontaneously-occurring and cholesterol-induced atherosclerosis of rhesus monkeys. a group of 30 normal monkeys were also studied. serum cholesterol, total phospholipid and triglyceride values in spontaneous atherosclerosis were similar to normal, but were significantly elevated in cholesterol-induced atherosclerosis. fractionation of the major phospholipids in animals with spontaneous atherosclerosis showed ... | 1975 | 1156469 |
| some connections of the entorhinal (area 28) and perirhinal (area 35) cortices of the rhesus monkey. i. temporal lobe afferents. | in this investigation the efferent projections from ventral temporal neocortical and limbic cortical areas to the entorhinal and perirhinal cortices have been investigated in the rhesus monkey using silver impregnation methods. it was observed that virtually all ventral temporal neocortical areas contribute some afferents to the transitional zones of periallocortex (perirhinal and prorhinal cortices) forming the walls of the rhinal sulcus. these areas in turn project medially to the entorhinal c ... | 1975 | 1156859 |
| some connections of the entorhinal (area 28) and perirhinal (area 35) cortices of the rhesus monkey. ii. frontal lobe afferents. | in this investigation, the efferent cortico-cortical projections of the orbitofrontal cortex in the rhesus monkey have been investigated using silver impregnation methods. projections from this area were observed to terminate in the rostral portions of the temporal lobe (areas ta, te and tg) and cingulate gyrus (area 24), the insular cortex, and some dorsolateral prefrontal areas. although these connections characterized all areas, with the exception of walker's area 14 and bonin and bailey's ar ... | 1975 | 1156867 |
| some connections of the entorhinal (area 28) and perirhinal (area 35) cortices of the rhesus monkey. iii. efferent connections. | in this investigation the efferent projections of the entorhinal and prorhinal cortices relative to their sites of termination in the hippocampus and fascia dentata were investigated in the rhesus monkey using experimental silver impregnation methods. contrary to the often cited observations of lorente de no, all entorhinal areas, including the laterally lying prorhinal cortex, were found to give rise to the perforant pathway, and furthermore, each cytoarchitectonically defined subarea was found ... | 1975 | 1156868 |
| resuscitation of the monkey brain after one hour complete ischemia. iii. indications of metabolic recovery. | adult rhesus monkeys were subjected to complete cerebral ischemia for one hour and subsequent recirculation for up to 24 h. animals with signs of functional recovery (e.g. spontaneous eeg activity) exhibited a partial replenishment of cellular energy sources (atp, phosphocreatine) and a progressive normalization of cerebral lactate levels. glucose and pyruvate concentrations showed a transient increase over control values during the early stages of postischemic recirculation. monkeys without fun ... | 1975 | 1156869 |
| merozoite vaccination against plasmodium knowlesi malaria. | free malarial merozoites isolated from in vitro cultures of p. knowlesi and emulsified with freund's complete (fca) or incomplete (fia) adjuvant were used to vaccinate twelve rhesus monkeys against the uniformly lethal infection caused by p. knowlesi. initial challenge of six monkeys with the same parasite variant as used for vaccination produced no detectable infection in three monkeys, while three others developed low-grade parasitaemia (maximum 1.5 per cent), which terminated after 6-11 days. ... | 1975 | 1158390 |
| electrocardiographic studies in the stumptail macaque (macaca arctoides). | our study has defined normal electrocardiographic standards for macaca arctoides. it appears that certain species differences exist in the electrocardiogram (ecg) in monkeys and that different criteria for normality may be necessary. thus, in apparently normal macaca arctoides a high frequency of q waves and st segment elevations of the j point type are present compared to macaca mulatta. it is suggested that normal ecg criteria be established for each species of monkeys to allow accurate interp ... | 1975 | 1159349 |
| intralymphatic injection of bcg into rhesus monkeys. | since the route of administration of bcg may have an important function in immunotherapy, we investigated intralymphatic administration to direct bcg to the lymph nodes. multiple injections of high doses of bcg were administered to 6 rhesus monkeys via the dorsal lymphatics of the lower limb. a suppurative lymphadenitis was observed along the lower limb and in the inguinal area in 5 of the 6 monkeys. however, many of the complications reported with other routes of administration were not observe ... | 1975 | 1159846 |
| varying temporal placement during cs of an added stimulus correlated with non-delivery of ucs. | this experiment extends pavlov's method of contrasts for training a stimulus discrimination to the case of the cardiac conditional response in the rhesus monkey. it explores the parameter of temporal placement of an additional stimulus ("cs2") within a 10-sec cs (or "cs1"), with the appearance of the former stimulus on any trial signalling the absence of ucs (electric shock) on that trial. this experimental paradigm is a parallel to that of the "intruded stimulus" studies in operant conditioning ... | 1975 | 1161337 |
| food- and drug-reinforced responding: effects of dita and d-amphetamine. | intravenous pretreatment with dita (0.1 - 1.0 mg/kg) decreased the rate of food-reinforcement lever pressing in rhesus monkeys. response rate decreases were dose-dependent but showed the development of tolerance. self-administration of dita was initiated and maintained in each of three monkeys when 30 lever presses were required to produce each injection. maximal response rate during periods of drug availability was maintained by 0.03 mg/kh/injection while higher and lower doses (0.01 and 0.10 m ... | 1975 | 1161990 |
| vegetative innervation of the esophagus. ii. intraganglionic laminar endings. | the intraganglionic laminar endings in the esophagus of the cat and the rhesus monkey show absolute equivalence between the results in both species from the morphological standpoint. the different types of apparatus found are described, with their location in the esophagus and their percentage distribution in relation to the different portions of its wall. the osmium tetroxide-zinc iodide technique gives pictures equivalent to those using silver impregnations, with the added advantage that the f ... | 1975 | 1163197 |
| protein deprivation in primates. v. fetal mortality and neonatal status of infant monkeys born of deprived mothers. | seventy-four pregnancies were followed in 45 rhesus monkeys. while pregnant the mothers were fed a semisynthetic diet affording 1, 2, or 4 g protein/kg per day. the poorer diets tended to produce excess fetal mortality, but liveborn infants born to 1-g and 2-g mothers averaged as large as those in the 4-g group. no differences existed in total protein concentration and albumin-globulin ratios in the sera of newborn infants. | 1975 | 1163481 |
| animal model of human disease. endometriosis. animal model: endometriosis in rhesus monkeys. | | 1975 | 1163633 |
| mapping of the immune response genes in the major histocompatibility complex of the rhesus monkey. | interest in the ir genes of rheus monkeys stems from their phylogenetic relationship to man and the extensive data already available on the major histocompatibility complex of the monkey. at least two independent dominant h-linked ir genes have been identified in the rhesus. these genes control the ability of monkeys to respond to the random linear copolymer of glutamyl alanine (ga), or the dinitrophenyl conjugate of glutamyl lysine (dnp-gl). these synthetic polymers can elicit weak delayed-type ... | 1975 | 1165471 |
| effect of pyrimethamine and sulfadiazine on the fine structure and multiplication of toxoplasma gondii in cell cultures. | rhesus monkey kidney cell cultures were inoculated with toxoplasma gondii organisms obtained from peritoneal fluid of mice infected with the rh strain. pyrimethamine and sulfadiazine were added either singly or in combination to the cultures 4 hr after inoculation. twenty-four hours later the effect of the drugs on the parasites were studied by light and electron microscopy. pyrimethamine (1.0 mug/ml) inhibited multiplication of the parasites and caused striking morphological changes. organisms ... | 1975 | 1165554 |
| studies on the transmission of simian malaria. vi. mosquito infection and sporozoite transmission of plasmodium fragile. | anopheles b. balabacensis mosquitoes were infected with plasmodium fragile when fed upon splenectomized macaca mulatta monkeys. highest level mosquito infections were obtained when feedings were made from 2 to 4 days prior to the peak in the parasitemia. transmission to m. mulatta monkeys was obtained via mosquito bite on 2 occasions and via intrahepatic and intravenous inoculation of dissected infected salivary glands on 9 occasions. the prepatent periods ranged from 12 to 17 days with a median ... | 1975 | 1165555 |
| satiety: a graded behavioural phenomenon regulating caloric intake. | rhesus monkeys inhibited their feeding in response to intragastric nutrient preloads, so as to maintain a constant caloric intake. there is a definite dose- response relationship to calories which does not depend on the volume, caloric concentration, or nature of the nutrient. this accurate control is accomplished even though some of the preload remains in the stomach throughout the feeding period. | 1975 | 1166310 |
| the effects of implanting testosterone propionate into the central nervous system on the sexual behaviour of adrenalectomised female rhesus monkeys. | bilateral adrenalectomy rendered ovariectomised, oestrogen-treated female rhesus monkeys sexually unreceptive. small unilateral implants of testosterone propionate (mean weight 140 mug) into the anterior hypothalamus/preoptic area restored receptivity in 7 out of 8 of these monkeys. cholesterol implanted into the same area, or similar amounts of testosterone propionate implanted into the posterior hypothalamus/pretectal area (4 females) or cerebral cortex/dorsal thalamus (5 monkeys) had no consi ... | 1975 | 1167802 |
| surgical disconnection of the medial basal hypothalamus and pituitary function in the rhesus monkey. ii. gh and cortisol secretion. | eighteen female rhesus monkeys subjected to complete or anterior disconnection of the medial basal hypothalamus (mbh) were studied to assess the effects of these deafferentation procedures on gh and cortisol secretion. basal serum levels of gh were not disturbed or were slightly elevated following complete or anterior mbh disconnection. gh secretion in response to vasopressin administration or insulin hypoglycemia, however, was abolished by complete isolation of the mbh. in contrast, the elevati ... | 1975 | 1168127 |
| consequences of social conflict on plasma testosterone levels in rhesus monkeys. | four adult male rhesus monkeys formed a new social group with 13 adult females. the male who became dominant [alpha] showed a progressive increase in plasma testosterone. the male who became subordinate to the other three males showed an 80% fall in testosterone from baseline levels. after 7 weeks, this group was introduced to a well-established breeding group, and all four males became subordinate to all members of the breeding group. all four males evidenced a fall in testosterone during the f ... | 1975 | 1168355 |
| further studies of the neural mechanisms of ketamine-induced anesthesia in the rhesus monkey. | bipolar stimulation of tooth pulp was used to elicit evoked potentials in the cortex, thalamus, and midbrain reticular formation (mbrf) of 4 monkeys. averaged evoked potentials in mbrf and medial thalamic nuclei were either completely obliterated or markedly reduced in amplitude by anesthetic dosages of ketamine. in contrast, little effect was observed upon the primary response elicited in the ventrobasal complex of the thalamus. these results suggest that anesthetic doses of ketamine block affe ... | 1975 | 1168426 |
| impaired hepatic release of triglycerides: a possible cause of acute alcoholic fatty liver in the rhesus monkey. | 1. the mechanism of development of acute alcoholic fatty liver in the rhesus monkey was investigated by studying the effect of triton wr-1339 on plasma triglycerides. 2. after ethanol infusion, the rise in plasma triglyceride produced by triton was greatly reduced and there was an accumulation of triglyceride in the liver. 3. thus findings suggest that acute alcoholic fatty liver in rhesus monkeys is probably due to a defect in the release of triglyceride from the liver. | 1975 | 1168560 |
| maternal psychological stress and fetal asphyxia: a study in the monkey. | fifteen pregnant rhesus monkeys near term were anesthetized with pentobarbital. catheters were placed into the right femoral arteries of the mother and fetus, the fetuses being retained in utero. after repair of all incisions, the mothers were placed on their sides and allowed to recover from anesthesia. as they awakened, their fetuses regularly developed blood chemical and, frequently, vital signs changes indicative of deepening asphyxia. in eight cases, anesthesia was reinstated with intraveno ... | 1975 | 1168995 |
| placental transfer of glutamate and its metabolites in the primate. | when radioactive glutamate was infused into pregnant rhesus monkeys, 69 to 88 per cent of radioactivity in the maternal plasma remained in association with glutamate while 10 to 22 per cent was converted to glucose. in the fetal plasma, glucose and lactate accounted for more than 80 per cent of radioactivity, with less than 2 per cent of the label found in glutamate. maternal glutamate infusions resulting in a ten- to twenty-fold increase in maternal plasma glutamate levels (60 to 100 mumoles pe ... | 1975 | 1168996 |
| ocular effects of a 325 nm ultraviolet laser. | corneal exposures were made on 100 eyes of anesthetized rhesus monkeys with a continuous wave hecd ultraviolet laser at a wavelength of 325 nm. the ed-50 corneal damage probability point was determined to be 0.8 joules of energy. this is higher than the levels for damage reported for noncoherent ultraviolet sources. however, the endpoint used here was a well-defined circumscribed lesion as contrasted to the appearance of granules used for the broad band, wide-beam, noncoherent studies. the granu ... | 1975 | 1169000 |
| initial heterosexual behavior of adolescent rhesus monkeys (macaca mulatta). | this report described the first heterosexual encounters of twelve 3-year-old rhesus monkeys, six of each sex. the subjects were all laboratory-born and were reared in wire cages for the first 8 months of life, accompanied only by their mothers. after these animals were weaned, each was placed in a cage with another animal of the same age and sex. the pairs formed in this way remained intact until the animals were 2 years old. when heterosexual dyads were formed, some of the subjects attached and ... | 1975 | 1169048 |
| effects of hypotension on rhesus monkeys. | twenty-one late-juvenile rhesus monkeys were rendered profoundly hypotensive for 0-, 15-, or 30-minute periods by means of infusion of trimethaphan camsylate. blood pressure was then restored to prehypotensive levels with phenylephrine infusions. respiratory gas tensions and ph of arterial blood were maintained within their normal limits throughout experimental and recovery periods. animals either recovered and showed no sequelae or diet 12 to 48 hours later of cardiorespiratory difficulties, of ... | 1975 | 1169051 |
| effect of uncertainty on emotionality and ethanol self-selection in monkeys with cortical ablations. | alcohol selection and emotionality were examined in rhesus monkeys with frontal cortical ablations which had been subjected to stress via an "uncertainty" paradigm. uncertainty produced a higher selection of alcohol as compared to nonstress situations. controls and dorsolateral subjects when exposed to uncertainty selected more of an alcohol solution than either orbital stressed or control-nonstressed animals. emotionality changes during alcohol-loading and control conditions were measured by re ... | 1975 | 1169992 |
| fixed-ratio escape and avoidance-escape from naloxone in morphine-dependent monkeys: effects of naloxone dose and morphine pretreatment. | lever pressing by rhesus monkeys was maintained by morphine injections during four equally spaced sessions each day. during other periods, lever pressing was maintained by timeout from a continuous naloxone infusion (escape), or by timeout from a stimulus that preceded naloxone injections, or termination of the injections (avoidance-escape). as naloxone dose increased in the escape procedure, response rate increased to a maximum and then decreased. in the avoidance-escape procedure, response rat ... | 1975 | 1170272 |
| [spontaneous chromosome aberrations in primary kidney cultures from macaca mulatta monkeys]. | | 1975 | 1170658 |
| hormone-releasing silastic intrauterine devices: effect or provera-releasing intrauterine devices on two species of primates. | silastic intrauterine contraceptive devices (iuds) 13 mm long and 1.07 mm in diameter could be inserted easily into patas monkey uteri which, like human uteri, expelled them. addition of 10% provera to these devices did not reduce the expulsion rate significantly in our study. control devices had no effect on cycle length in rhesus monkeys. after insertion, the active iuds frequently caused a delay in onset of menstruation; however, cycles did occur with the device in situ, and normal-length cyc ... | 1975 | 1171027 |
| chronic cerebellar stimulation in the monkey. electron microscopic and biochemical observations. | the effects of chronic electrical stimulation to the surface of cerebellum in the macaca mulatta monkey were studied with morphologic and biochemical techniques. there was considerable damage and loss of purkinje cells in all specimens examined, including an area without electrodes, but the greatest changes appeared in tissue beneath the cathode and anode. despite the damage, normal appearing synapses persisted in the molecular layer of all specimens. fibrous glial processes were more numerous b ... | 1975 | 1171397 |
| implantation and maintenance of pregnancy in mated rhesus monkeys following bilateral oophorectomy or luteectomy with and without progesterone replacement. | six mated rhesus monkeys were bilaterally oophorectomized between the fourth and sixth day after ovulation, and received silastic implants containing crystalline progesterone subcutaneously. five mated monkeys were subjected to luteectomy 5 or 6 days after ovulation. three of these received progesterone implants subcutaneously. pregnancy occurred in one oophorectomised monkey and in all three luteectomised monkeys treated with progesterone. it was evident from the steroid patterns observed in th ... | 1975 | 1173510 |
| acetylcholinesterase-positive nerves of the rhesus monkey bronchial tree. | the rhesus monkey lung was stained both by histological methods and histochemically for specific acetylcholinesterase (ache). ache-containing nerves in bundles were demonstrated in connective tissue of the hilum and in association with clusters of ganglion cells. these bundles become associated with the bronchial tree as they enter the lung parenchyma, and their numbers of myelinated fibres diminish as they pass scattered ganglion cells along the bronchial system. extrachondral and subchondral p ... | 1975 | 1179313 |
| viral hepatitis, type b, in experimental animals. | evidence of natural infection with hepatitis b virus (hbv) in chimpanzees was followed by demonstration that this species provides a highly sensitive animal model system for experimental type b hepatitis. with rare exceptions, inoculation of sero-negative chimps with materials containing infectious hbv produces serologic evidence of infection including appearance of circulating hepatitis b surface antigen (hbs ag) and subsequently development of antibody to hbs ag and hepatitis b core antigen. s ... | 1975 | 1181931 |
| protein deprivation in primates: vi. food preferences of adult rhesus monkeys maintained on low-protein diets. | three groups of adult female rhesus monkeys, maintained on low-protein diets (.5 gm, 1 gm, and 2 gm protein per kg body weight, were compared with a control group (4 gm protein per kg body weight) on a food-preference task. food responsiveness was assessed by presenting 8 small pieces of a certain food, equally spaced about the perimeter of a turntable attached to the home cage, and recording number of pieces taken, number of pieces eaten, and elapsed time for taking all 8 pieces. 21 different f ... | 1975 | 1182038 |
| eustachian tuboplasty. | until recently a practical method of reconstruction of the osseous eustachian tube, stenosed by bony or connective tissue, was yet to be evolved. this paper recommends a new surgical procedure illustrating the possibility of reaching the isthmus of the eustachian tube by way of a combined transcanal and preauricular approach. after initial cadaveric dissections the basic surgical anatomy was worked out in two rhesus monkeys. subsequently within the duration of one-and-a-half years two cases of o ... | 1975 | 1185063 |