| guidelines for preventing the transmission of tuberculosis in health-care settings, with special focus on hiv-related issues. | the transmission of tuberculosis is a recognized risk in health-care settings. several recent outbreaks of tuberculosis in health-care settings, including outbreaks involving multidrug-resistant strains of mycobacterium tuberculosis, have heightened concern about nosocomial transmission. in addition, increases in tuberculosis cases in many areas are related to the high risk of tuberculosis among persons infected with the human immunodeficiency virus (hiv). transmission of tuberculosis to persons ... | 1990 | 2175838 |
| characterization of a mycobacterium tuberculosis insertion sequence, is6110, and its application in diagnosis. | an insertion sequence-like element, is6110, was isolated from a mycobacterium tuberculosis cosmid library as a repetitive sequence. is6110 shows similarities with elements of the is3 family. this insertion sequence was found to be specific to mycobacteria belonging to the m. tuberculosis complex. for detection and identification of m. tuberculosis bacilli in uncultured specimens, oligonucleotides derived from the is6110 sequence were used as primers and probes in polymerase chain reaction studie ... | 1990 | 2177747 |
| [acute tuberculous pancreatitis in a patient with acquired immunodeficiency syndrome]. | the authors report a case of tuberculous pancreatitis in a 29 year old zairan man. serum antibodies against hiv were positive. t-lymphocyte analysis revealed 18/mm3 okt4 with an okt4/okt8 ratio of 0.43. the initial examination suggested severe acute pancreatitis. only the postmortem histopathological analysis revealed tuberculous pancreatitis, showing several miliary lesions with caseous necrosis and acid fast bacili (ziehl stain). subsequently, cultures (sputum, bronchoalveolar lavage, pleural ... | 1990 | 2179013 |
| the pathology and pathophysiology of mycobacterial infections. | classic tuberculosis is the result of infection with the human strain of mycobacterium tuberculosis, and atypical tuberculosis is the result of infection with atypical mycobacteria. the pathology and course of the disease depend on the sensitivity of the host. primary tuberculosis is the first infection in an unsensitized host, and secondary, postprimary, or chronic tuberculosis results from reactivation of previously acquired infection or, rarely, reinfection of a sensitized host. the pathology ... | 1990 | 2182905 |
| use of a tuberculin purified protein derivative--asn-ala-asn-pro conjugate in bacillus calmette-guérin primed mice overcomes h-2 restriction of the antibody response and avoids the need for adjuvants. | because of its immunodominancy, and because it is conserved in different geographical isolates of plasmodium falciparum, the repetitive sequence of the circumsporozoite protein, (asn-ala-asn-pro)n [(nanp)n], has been envisaged for the development of an anti-falciparum malaria subunit vaccine. however, the murine immune response to (nanp)n peptides, either carrier-free or coupled to carrier proteins, was shown to be inducible only by using strong (e.g., freund's) adjuvants. furthermore, response ... | 1990 | 2183219 |
| nonoperative antiinfective treatment of intraabdominal infections. | there are many causes of peritonitis. primary peritonitis is rare, but may complicate cirrhosis of the liver or may, in developing countries, be caused by mycobacterium tuberculosis. it is occasionally iatrogenic, particularly as a complication of continuous ambulatory peritoneal dialysis. it is, however, most frequently the result of perforation of a hollow viscus, caused by either trauma or disease. its most lethal form follows breakdown of an intestinal anastomosis. primary and iatrogenic per ... | 1990 | 2183486 |
| tuberculous abscess of the testicle in aids: sonographic demonstration. | a patient with acquired immune deficiency syndrome (aids) who presented with right testicular swelling is described. sonography demonstrated diffuse enlargement and inhomogeneity of the testicle with central hypoechoic areas. testicular abscesses were seen at surgery and mycobacterium tuberculosis was cultured from the surgical specimen. tuberculosis should be considered in the differential diagnosis of testicular enlargement or abscess formation in aids. | 1990 | 2185592 |
| [infections caused by mycobacterium africanum]. | mycobacterium africanum is a bacterial species that was singled out in 1969. its biochemical and cultural characteristics are intermediary between those of mycobacterium tuberculosis and mycobacterium bovis. this bacteria is responsible for tuberculosis in both western and central africa. we can distinguish between four different types dependent upon the geographical origins of the patients. the extent of this case, with multiple cutaneous and visceral lesions, could not be explained by a past o ... | 1990 | 2190671 |
| tuberculosis of the skull--a rare condition: case report and review of the literature. | a 25-year-old woman exhibited swelling of the scalp and a bony defect of the skull from which mycobacterium tuberculosis was cultured. the case is reported, and the literature is reviewed. | 1990 | 2191243 |
| characterization of the heat shock response and identification of heat shock protein antigens of borrelia burgdorferi. | the heat shock response of borrelia burgdorferi b31 cells was characterized with regard to the heat shock proteins (hsps) produced. five to seven hsps were detected by sodium dodecyl sulfate-gel electrophoresis and fluorography of proteins from cells labeled with [35s]methionine after shifts from 33 degrees c to 37 or 40 degrees c or from 20 degrees c to 33, 37, or 40 degrees c. analysis of [35s]methionine-labeled hsps by two-dimensional electrophoresis and autoradiography revealed 12 hsps. west ... | 1990 | 2194963 |
| the use of paraffin wax metabolism in the speciation of mycobacterium avium-intracellulare. | paraffin-wax utilisation or baiting of mycobacterium avium-intracellulare (mai) complex organisms and other 'atypical mycobacteria' and the inability of mycobacterium tuberculosis to utilise paraffin are known and useful if forgotten facts. strains of possible aids-related mai have been introduced into czapek broth devoid of any carbon source other than paraffin-wax coated slides. replicate slides showing 'in situ' growth were subjected to the following battery of tests: acid alcohol fast staini ... | 1990 | 2196726 |
| serodiagnosis of tuberculosis using an elisa with antigen 5 and a hemagglutination assay with glycolipid antigens. results in patients with newly diagnosed pulmonary tuberculosis ranging in extent of disease from minimal to extensive. | hemagglutination tests with three glycolipid antigens, a1, b1, and c, and elisa with antigen 5 were done on serum from chinese patients with pulmonary tuberculosis and from normal subjects in hong kong. tests with all four antigens were of similar efficiency, giving positive results in 30 to 52% of 88 smear-positive patients, in 16 to 22% of 37 smear-negative, culture-positive patients, in 5 to 13% of 76 culture-negative patients with radiologically active disease, in 5 to 11% of 217 culture-neg ... | 1990 | 2200316 |
| impact of human immunodeficiency virus on transmission and severity of tuberculosis. | it is now clear that tuberculosis is one of the major diseases associated with human immunodeficiency virus (hiv) infection and the acquired immune deficiency syndrome both in developing countries and in disadvantaged groups in the northern hemisphere. in the usa, and probably several other countries, the annual incidence of tuberculosis is rising as a result of the hiv epidemic. this is probably a result of an increase in both pulmonary and, especially, extrapulmonary tuberculosis, due to react ... | 1990 | 2201113 |
| the major native proteins of the leprosy bacillus. | this study addresses a major obstacle to vaccine development for leprosy, the isolation and characterization of the native protein antigens of the leprosy bacillus. mycobacterium leprae harvested from armadillos was subjected to a simple fractionation protocol to arrive at the three major subcellular fractions, cell walls, cytoplasmic membrane, and soluble cytoplasm. the application of extensive detergent phase separations to membrane fractions allowed removal of lipoarabinomannan and the mannos ... | 1990 | 2201679 |
| detection and identification of mycobacteria by amplification of rrna. | oligonucleotides specific at a genus, group, or species level were defined by a systematic comparison of small-subunit rrna sequences from mycobacterium tuberculosis, m. bovis, m. africanum, m. bovis bcg, m. avium, m. kansasii, m. marinum, m. gastri, m. chelonae, m. smegmatis, m. terrae, m. nonchromogenicum, m. xenopi, m. malmoense, m. szulgai, m. scrofulaceum, m. fortuitum, m. gordonae, m. intracellulare, m. simiae, m. flavescens, m. paratuberculosis, m. sphagni, m. cookii, m. komossense, m. ph ... | 1990 | 2203812 |
| legionella pneumophila htpab heat shock operon: nucleotide sequence and expression of the 60-kilodalton antigen in l. pneumophila-infected hela cells. | a 60-kilodalton (kda) immunodominant antigen of legionella pneumophila is a heat shock protein (hsp) of the groel class of hsps. the gene (htpb) coding the 60-kda protein was localized to a 3.2-kilobase dna fragment of l. pneumophila cloned into puc19 (psh16) (p. s. hoffman, c. a. butler, and f. d. quinn, infect. immun. 57:1731-1739, 1989). the nucleotide sequence of the dna fragment cloned into m13 confirmed two open reading frames, htpa and htpb, that code for proteins of 96 and 548 amino acid ... | 1990 | 2205580 |
| sequential monitoring of leprosy patients with serum antibody levels to phenolic glycolipid-i, a synthetic analog of phenolic glycolipid-i, and mycobacterial lipoarabinomannan. | sequential serum samples from leprosy patients at various stages of antibacterial treatment were tested by an elisa for antibodies to phenolic glycolipid i (pgl-i), a synthetic pgl-i analog (nd-bsa), and lipoarabinomannan (lam) from mycobacterium tuberculosis to determine if these antibodies could be useful in monitoring response to therapy. among patients with positive initial anti-pgl-i igm, a significant decrease in this antibody was seen over time (p less than 0.01), whether assayed by pgl-i ... | 1990 | 2205685 |
| evidence for the nature of the link between the arabinogalactan and peptidoglycan of mycobacterial cell walls. | the long-posed question of the nature of the link between the mycolylarabinogalactan and the underlying peptidoglycan of the cell walls of mycobacterium sp. has been addressed. the insoluble cell wall matrix of mycobacterium leprae, mycobacterium tuberculosis, and mycobacterium bovis was partially hydrolyzed with acid either before or after per-o-methylation and the resulting oligosaccharides further derivatized and analyzed by gas chromatography/mass spectrometry. the structures of fragments ar ... | 1990 | 2211696 |
| [a case of tuberculoma of the orbit with sphenoidal origin]. | we report the case of an orbital and sphenoidal tuberculosis observed in a young indian man living in france. the orbital disease is presenting as an orbital mass with a radiologic bony lytic aspect, without systemic manifestation. a malignant process was suspected. the diagnosis was obtained by the culture for mycobacterium tuberculosis of the biopsy specimen. orbital involvement in tuberculosis is a rare manifestation in developed countries. most cases reported in the literature were reported ... | 1990 | 2212510 |
| [generalized histoplasmosis in 3 patients with an hiv infection]. | three patients with generalized histoplasmosis and the acquired immunodeficiency syndrome (aids) are described. symptoms of generalized histoplasmosis in patients with aids are not specific and concomitant opportunistic infections frequently occur. two patients suffered from an infection by mycobacterium tuberculosis, one patient had pneumocystis carinii pneumonia, and one had cerebral toxoplasmosis. one patient had serological results positive for histoplasma capsulatum. two of the three patien ... | 1990 | 2215745 |
| [the role of bronchoscopy with a flexible bronchoscope in the diagnosis of pulmonary tuberculosis]. | bronchoscopy with flexible bronchoscope has been proved as a useful method that has been applied also in the diagnostics of pulmonary tuberculosis during the recent years. in order to evaluate its role and use at the institute for diseases of the chest and tuberculosis golnik documentation of 51 patients treated during 1985 and 1986 was surveyed. prior to the examination from all patients the sputum on mycobacterium tuberculosis was obtained at least three times and it was negative. aspirations ... | 1990 | 2217620 |
| [tuberculosis of the peripheral lymph nodes]. | an analysis of 2.414 fine needle aspiration specimens, obtained from peripheral lymph nodes, was done in 2.287 patients during the period from 1979 till the end of 1989. this investigation was performed at the cytologic laboratory of the clinic for lung diseases "jordanovac" in zagreb. totally, there were 150 (6.2%) aspirates which, cytomorphologically, appeared to have a granulomatous reaction with necrosis. of 150 aspirates, mycobacterium tuberculosis was found microscopically and/or by cultur ... | 1990 | 2217640 |
| [tuberculosis of the cavum, report of two cases]. | the authors report two cases of nasopharynx tuberculosis. this location is rare or misestimated. the sarcoidosis, the wegener's granulomatis can be discussed. the diagnosis confirmation is based on the histologic features as a caseous necrosis in a langhans reaction cells or as the presence of mycobacterium tuberculosis at a ziehl-nielson coloration. the authors insist on the interest of a systematic biopsy of the nasopharynx at the presence of a nasopharynx lesion or a primitive cervical lymph- ... | 1990 | 2218120 |
| pleuritis as a manifestation of reactivation tuberculosis. | the purpose of this study was to determine the frequency with which tuberculous pleuritis is a manifestation of reactivation tuberculosis and to compare the clinical manifestations of reactivation tuberculous pleuritis with "classic" tuberculous pleuritis, in which chest roentgenograms reveal no parenchymal infiltrates. | 1990 | 2220878 |
| caseating hepatic granulomas in hodgkin's lymphoma. | a 68-year-old man presented with recurrent hodgkin's lymphoma after a 9-year disease-free interval induced by chemotherapy. in addition to histological evidence of recurrent hodgkin's disease, the liver biopsy specimen showed extensive caseating granulomas. cultures of bone marrow and liver tissue tested negative for mycobacterium tuberculosis. no antituberculous treatment was administered, and the patient had an excellent clinical response to additional chemotherapy for lymphoma. hodgkin's lymp ... | 1990 | 2227301 |
| comparative in-vitro activities of ten fluoroquinolones and fusidic acid against mycobacterium spp. | the in-vitro activities of eight new quinolones (a-56620, amifloxacin, difloxacin, ci-934, enoxacin, irloxacin, pefloxacin, temafloxacin), two reference fluoroquinolones (ciprofloxacin and ofloxacin) and fusidic acid against 147 mycobacterial strains, belonging to seven different species, were compared. temafloxacin, ofloxacin and ciprofloxacin were the most active compounds. they only showed consistent activity against mycobacterium tuberculosis, m. malmoense and m. fortuitum, but not against m ... | 1990 | 2228828 |
| miliary tuberculosis presenting as skin lesions in a patient with acquired immunodeficiency syndrome. | acute miliary tuberculosis of the skin is an extremely rare infection that occurs in immunocompromised persons. we report an intravenous drug abuser with human immunodeficiency virus infection in whom erythematous papules developed on the trunk and proximal aspect of the extremities. visceral lesions of unsuspected miliary tuberculosis were discovered at autopsy, and the cutaneous papules were found to contain mycobacterium tuberculosis. this is the first reported case of this cutaneous infectio ... | 1990 | 2229536 |
| cloning and characterization of the gene for the '19 kda' antigen of mycobacterium bovis. | monoclonal antibody cma134.1 reacted with a protein antigen of apparent molecular mass 22 kda from mycobacterium bovis and mycobacterium tuberculosis, and with an apparently 24 kda antigen of mycobacterium kansasii, but not with other mycobacteria or related species. this antibody was used to screen a gene library of m. bovis in lambda gt11 and identified a recombinant clone that expressed a protein with an apparent molecular mass of 19-20 kda. gene expression occurred from the lac promoter in l ... | 1990 | 2230723 |
| tuberculous psoas muscle abscess following chemoprophylaxis with isoniazid in a patient with human immunodeficiency virus infection. | a 34-year-old man with human immunodeficiency virus infection and disseminated mycobacterium avium and mycobacterium intracellulare infection developed a right psoas muscle abscess due to mycobacterium tuberculosis. the abscess occurred 18 months after completion of a 12-month course of chemoprophylaxis with isoniazid that was given because of a positive reaction with purified protein derivative of tuberculin. the adjacent vertebrae did not appear to be involved. the abscess was drained with a p ... | 1990 | 2237113 |
| some early observations on hiv infection in children at king edward viii hospital, durban. | nine black children aged between 3 months and 30 months of age, with human immunodeficiency virus type i (hiv-i) infection are described to draw the attention of health professionals in southern africa to special clinical characteristics useful for recognising this problem, which has many shared features with common diseases of infancy and childhood in the third world. the main presenting complaints were chronic cough and persistent diarrhoea and vomiting. these children frequently had diarrhoea ... | 1990 | 2237685 |
| aids and tuberculosis. | the diagnostic and therapeutic implications of human immunodeficiency virus (hiv) infection and tuberculosis in south africa, where tuberculosis remains a major health problem, are reviewed. mycobacterium tuberculosis is a high-grade pathogen and is able to establish infection early in immunodeficiency. with hiv infection showing significant entry into the heterosexual population in the rsa, an increasing number of cases with both infections can be expected to occur. the radiological appearance ... | 1990 | 2237687 |
| papulonecrotic tuberculid in a 9-year-old american girl: case report and review of the literature. | papulonecrotic tuberculid is a rare cutaneous manifestation of tuberculosis that can also be associated with other mycobacteria. clinically, it is an asymptomatic, recurrent eruption of papules with a necrotic center in a symmetric, acral distribution. tubercle bacilli are not present in skin biopsies. the eruption resolves promptly with antituberculoid therapy. few patients with this entity have been reported in the united states over the last 50 years. we report a 9-year-old, otherwise healthy ... | 1990 | 2247386 |
| tuberculous meningitis. short course of chemotherapy. | in march 1986, we began a 6-month short course trial of therapy for tuberculous meningitis, in which 28 patients were analyzed. the diagnosis was based on the following cerebrospinal fluid test results: in 53.5% of the cases, mycobacterium tuberculosis was identified by direct smear; in 57%, culture in löwenstein-jensen medium was positive; in 83.3%, the detection of anti-bacille calmette-guérin (bcg) antibodies by enzyme-linked immunosorbent assay was positive; and in 74%, the dosification of a ... | 1990 | 2252448 |
| elisa for diagnosis of tuberculosis. | antigen a 60 of mycobacterium bovis is a cell wall antigen with almost complete cross reactivity with antigen a 60 of mycobacterium tuberculosis. this antigen was used for the elisa technique for 100 cases suspected of childhood tuberculosis to evaluate the usefulness of the method in the diagnosis. the positivity rate in pulmonary tuberculosis was 65.1%, in central nervous system tuberculosis 50.0% and in the miscellaneous group 76.4%. the overall positivity was 61.0%, proving the utility of th ... | 1990 | 2253994 |
| disseminated lymphatic tuberculosis in acquired immunodeficiency syndrome: computed tomography findings. | there is an increased frequency of disseminated tuberculosis in patients with acquired immunodeficiency syndrome (aids). the authors reviewed 6 thoracic and 10 abdominal computed tomography scans from 11 patients who had aids and disseminated tuberculosis. all scans demonstrated multiple, large, mediastinal or retroperitoneal lymph nodes, or both; low-density centers within enlarged nodes were identified in seven patients (63%). the scans also showed a diffuse miliary pattern (three patients), p ... | 1990 | 2257509 |
| mycobacterial infection after renal transplantation--report of 14 cases and review of the literature. | during a nine-year period, 14 cases of mycobacterial infection (tuberculosis) developed in 403 renal transplant recipients at the king faisal specialist hospital and research centre in riyadh, saudi arabia, an incidence of 3.5 per cent. the annual incidence of tuberculosis was about 50 times higher than that in the general population. infection was disseminated in nine (64.3 per cent), pulmonary in four (28.6 per cent), and genitourinary in 1 (7.1 per cent). in one patient tuberculosis was trans ... | 1990 | 2267281 |
| human immunodeficiency virus (hiv) and mycobacterium tuberculosis (tb). | current surveillance data indicate that the spread of human immunodeficiency virus (hiv) infection has increased the risk of mycobacterium tuberculosis (tb). after years of decline, in 1986, the centers for disease control (cdc) reported a 2.6% rise in the number of cases of tb. the dual diagnosis of tb and hiv infection is being reported more frequently, especially among the inner city poor, racial and ethnic minorities, and intravenous drug users. nurses need to be aware that intradermal tuber ... | 1990 | 2269899 |
| serum levels of soluble interleukin-2 receptor in pulmonary tuberculosis. | it is well known that the activation of cell mediated immunity has an important role in the pathogenesis of pulmonary tuberculosis and the production of the protective immunity against mycobacterium tuberculosis. during the activation of t-cell by interleukin-1 released from the macrophage, not only interleukin-2 but also the soluble interleukin-2 receptor (sil-2r) molecule is released into the extracellular fluid. in vitro study reveals that the level of this sil-2r is well correlated with the ... | 1990 | 2271510 |
| [characteristics of children infected by mycobacterium tuberculosis who previously had pneumonia]. | out of 674 m. tuberculosis infected children subjected to examination, 31.8% of them had pneumonia in their life. 38.3% of the latter had a repeated pneumonia. it was found that 29.9% of the children who had pneumonia were not registered by an antituberculosis dispensary. moreover, 75% of them were infected by tuberculosis over a number of years and did not receive any preventive treatment. among those struck off the register and examined before at an antituberculosis dispensary, 15.5% of the ch ... | 1990 | 2274501 |
| [differentiated examination of persons with mycobacterium tuberculosis infection for improvement of tuberculosis detection and prevention]. | tuberculosis morbidity in the adults, who were close relatives of infected children, is 5.2 times higher than the mean rate for the adult population; of them the individuals having 21 mm or more and 13-18 mm papules to the mantoux test with 2 tu ppd-l showed 10.6 and 3.8-fold rates, respectively. 40% of the infected were subjects aged 18 to 29 years and living in the families with affected parents. the group under observation included persons highly allergic to tuberculin in 6.3 times more than ... | 1990 | 2274502 |
| towards a phylogeny and definition of species at the molecular level within the genus mycobacterium. | 16s rrna sequences from mycobacterium tuberculosis, m. avium, m. gastri, m. kansasii, m. marinum, m. chelonae, m. smegmatis, m. terrae, m. gordonae, m. scrofulaceum, m. szulgai, m. intracellulare, m. nonchromogenicum, m. xenopi, m. malmoense, m. simiae, m. flavescens, m. fortuitum, and m. paratuberculosis were determined and compared. the sequence data were used to infer a phylogenetic tree, which provided the basis for a systematic phylogenetic analysis of the genus mycobacterium. the groups of ... | 1990 | 2275850 |
| [bactericidal activity of ofloxacin against mycobacterium kansasii]. | bactericidal activity of ofloxacin against mycobacterium kansasii was observed in in-vitro experiment. tested bacteria were suspended to a concentration of one mg wet weight per ml in 10 ml of dubos liquid medium containing no drug or containing 1 or 3 micrograms/ml ofloxacin and incubated at 37 degrees c. the number of colony-forming units contained in a 0.02 ml-sample of the dubos liquid medium was counted after incubation for 0, 1, 3 and 7 days. the number of colonies was counted in ogawa egg ... | 1990 | 2277465 |
| mycobacterium tuberculosis: a disease of growing importance in urban population groups. | | 1990 | 2277673 |
| the emergence of antibiotic resistance: myths and facts in clinical practice. | selection pressure, caused by the use of antibiotics--especially in hospitals--is the main factor responsible for the emergence of antibiotic-resistant bacteria. resistance can arise endogenously by mutation (one-step, as found for mycobacterium tuberculosis to rifampicin, or multi-step, as in gonococci to benzylpenicillin), or exogenously by transfer of r-factors. mechanisms of resistance may involve a decrease in permeability, chemical modification of the antibiotic, or a change in the affinit ... | 1990 | 2289992 |
| isolation of mycobacteria from stools and intestinal biopsies from hiv seropositive and hiv seronegative patients with and without diarrhea in kinshasa, zaïre. preliminary results. | to determine the role of mycobacteria as etiologic agent in hiv related enteritis in africa, the following study was performed in 1986, in the department of internal medicine in mama yemo hospital in kinshasa, zaire. stool and intestinal biopsies were obtained from hiv seropositive and hiv seronegative patients with and without diarrhea. patients with known mycobacterium tuberculosis infection were not enrolled. acid fast bacilli were found in fecal smears of 6 (10%) of 59 hiv seropositive patie ... | 1990 | 2291696 |
| modulation of human lepromatous monocyte-macrophage functions in vitro by tuftsin. | human peripheral blood monocytes/macrophages derived from normal donors, patients of tuberculoid leprosy (bt/tt) and lepromatous leprosy (bl/ll) were assayed for stimulated phagocytic responses to the potent macrophage stimulator "tuftsin" (nh2-thr-lys-pro-arg-oh) after varying periods (6 h to 14 days) of culture in vitro. the assays consisted of visual scoring of ingested mycobacterium leprae and radiometric measurement of ingested 14c-acetate labelled staphylococcus aureus and mycobacterium tu ... | 1990 | 2292463 |
| rapid diagnosis of bacterial meningitis by the detection of a fatty acid marker in csf with gas chromatography-mass spectrometry and selected ion monitoring. | a chemical marker of bacterial meningitis was sought by comparing derivatives of sterile cerebrospinal fluid (csf) with cultures of organisms in spinal fluid and artificial media. the technique of gas chromatography-mass spectrometry with selected ion monitoring (gc-ms-sim) was used, optimised for the analysis of fatty acids. twenty candidate ions were screened, and an ion of mass: charge ratio (m/e) 268 was chosen for detection in clinical specimens. the origin of this marker is unknown, but it ... | 1990 | 2296039 |
| racial differences in susceptibility to infection by mycobacterium tuberculosis. | the prevalence of tuberculosis among blacks is known to be about twice that among whites. when we looked at infection rates among the initially tuberculin-negative residents of 165 racially integrated nursing homes in arkansas, we were stimulated to investigate whether this difference could be due in part to racial differences in susceptibility to mycobacterium tuberculosis infection. a new infection was defined by an increase of greater than or equal to 12 mm of induration after a tuberculin sk ... | 1990 | 2300105 |
| genital tuberculosis: case report and literature review. | a 64-year-old woman complained of abdominal pain and postmenopausal bleeding. a uterine curettage demonstrated acid fast bacilli and non caseating granulomas, indicating mycobacterium tuberculosis. a chest roentgenogram revealed the presence of bilateral upper lobe calcific granulomas. the epidemiologic, diagnostic, and therapeutic implications of genital tuberculosis are discussed. | 1990 | 2301178 |
| comparative yield of blood culture for fungi and mycobacteria, liver biopsy, and bone marrow biopsy in the diagnosis of fever of undetermined origin in human immunodeficiency virus-infected patients. | the diagnostic yield of mycobacterial blood cultures, bone marrow biopsy, and liver biopsy for determining the cause of unexplained fever was compared prospectively in eight men and four women with serologic evidence of human immunodeficiency virus infection and fever of undetermined origin. mycobacterial infection was found in 8 of the 12 patients (mycobacterium tuberculosis in 3 and mycobacterium avium in 5). mycobacteria were isolated from the blood of 6 of these 8 patients. the mean interval ... | 1990 | 2302009 |
| the blood/cerebrospinal fluid partitioning of pyrazinamide: a study during the course of treatment of tuberculous meningitis. | concentrations of pyrazinamide were measured in serum and cerebrospinal fluid (csf) of 17 adult patients with tuberculous meningitis up to six months after starting treatment. pyrazinamide penetrated excellently into the csf and mean concentrations at various intervals up to six months of treatment were consistently above that required for inhibition of the growth of mycobacterium tuberculosis. the blood/csf partitioning of pyrazinamide does not change as the patients recover from the meningitis ... | 1990 | 2303836 |
| [a case of tuberculous pericarditis]. | a case of tuberculous pericarditis successfully managed with medical treatment alone was reported. a 78-year-old male was admitted because of cough, dyspnea and fever. chest x-p and echocardiogram revealed massive pericardial effusion. his clinical symptoms and signs suggested cardiac tamponade. mycobacterium tuberculosis was detected from pericardial fluid. ada activity in pericardial fluid was high. thoracic ct scan showed tracheobronchial, pretracheal, paratracheal and superior mediastinal ly ... | 1990 | 2313958 |
| [diagnostic value of bronchoscopy in diagnosis of pulmonary tuberculosis: bronchial aspirate, bronchial washing and transbronchial lung biopsy]. | the diagnosis of pulmonary tuberculosis is confirmed by the detection of mycobacterium tuberculosis in sputum. bronchoscopy has been used for diagnosis of various pulmonary diseases. the value of bronchoscopy such as bronchial aspirate, bronchial washing and transbronchial lung biopsy in diagnosis of pulmonary tuberculosis was evaluated, and the results were as follows: 1) one hundred ninety cases were investigated bronchoscopically due to suspicion of pulmonary tuberculosis with sputum negative ... | 1990 | 2313959 |
| [basic and clinical evaluation of rapid diagnosis of tuberculosis by detecting tuberculostearic acid]. | tuberculostearic acid (tsa) is known to be one of the characteristic lipid in the limited species of the order actinomycetale, including mycobacterium tuberculosis. we studied the significance of detecting tsa in the diagnosis of tuberculosis from clinical specimens collected from 791 patients with various respiratory diseases by using gas--chromatography/mass--spectrometry. by our method, the detectable limit of tsa was around 10(2)-10(3) bacilli of mycobacterium tuberculosis, and our method is ... | 1990 | 2313961 |
| [the serodiagnosis of tuberculosis by enzyme-linked immunosorbent assay with tuberculin purified protein derivative]. | tuberculin purified protein derivative (ppd) is a relatively crude antigen prepared from mycobacterium tuberculosis and has species nonspecificity in immunological reaction. it is, however, more readily available than more highly purified materials. therefore, the detection of igg antibody to ppd was done by enzymed-linked immunosorbent assay (elisa) and its diagnostic useful was evaluated in this study. the patients with active tuberculosis had significantly high titer of igg antibody to ppd co ... | 1990 | 2313962 |
| variation in immunogenicity of mycobacteria: role of antigen-presenting cells. | the antigen-presenting efficiency of peritoneal cells and irradiated spleen cells was compared using mycobacterium tuberculosis- and m. vaccae-primed t cells and corresponding sonicates as antigens in an in vitro lymphocyte transformation test. the presentation efficiency of irradiated spleen cells was reasonably good for both antigens. however, with peritoneal cells as the antigen-presenting cells, the proliferative response against only m. tuberculosis sonicate was good. proliferation of m. va ... | 1990 | 2319188 |
| [epidemiology of tuberculosis]. | in 1990, tuberculosis remains a major, world-wide problem, with 50 p. cent of the world's population being infected by mycobacterium tuberculosis. in france, the latest known figures show a continuous decrease in the incidence of tuberculosis, despite the risk due to the development of aids, but the situation is totally different in developing countries where tuberculosis ranks first among the infections associated with aids. this tb-aids association makes it necessary to maintain in epidemiolog ... | 1990 | 2320893 |
| [bacteriologic basis for the treatment of tuberculosis]. | to be fully effective, short-course chemotherapy for tuberculosis should take into account the slow growth rate, high oxygen requirement and high drug-resistant mutant emergence rate of mycobacterium tuberculosis, as well as the type of the lesions observed and the specific activity of each antituberculous drug. due to their unique sterilizing activities against bacilli that are not actively metabolizing, rifampicin and pyrazinamide are the key drugs for short-course chemotherapy. to prevent the ... | 1990 | 2320895 |
| a case of tularemia meningitis in sweden. | tularemia meningitis occurred in a previously healthy 64-year-old man from northern sweden. the patient was immunocompetent and recovered without sequelae. the bacterial isolate conformed by most criteria with the euro-asian biovar francisella tularensis var. palaearctica. tularemia meningitis may mimic meningitis caused by mycobacterium tuberculosis. | 1990 | 2320968 |
| mycobacterial infection in patients infected with the human immunodeficiency virus. | of 207 homosexual or bisexual patients with the acquired immune deficiency syndrome (aids), 24 with the aids related complex, and 39 with asymptomatic hiv infection, 32 patients were found to have mycobacterial infection. mycobacterium tuberculosis was found in 13 patients with aids and in two with the aids related complex. m avium-intracellulare was found in 15 patients with aids and was disseminated in 12. one patient was infected with m kansasii and one with m ulcerans. invasive procedures we ... | 1990 | 2321177 |
| tuberculous empyema necessitatis. computed tomography findings. | two patients who presented with an anterior chest wall mass were evaluated by computed tomography (ct) scan and were found to have an associated thick-walled pleural collection, consistent with empyema necessitatis. in view of the increasing incidence of pulmonary and extrapulmonary mycobacterium tuberculosis infection, the entity of tuberculous empyema necessitatis should be strongly considered when the described ct findings are present. | 1990 | 2322879 |
| esophageal fistulas associated with mycobacterial infection in patients at risk for aids. | although opportunistic infections of the esophagus occur commonly in acquired immunodeficiency syndrome (aids), inflammation is generally limited to the mucosal surface. during a 7-month interval, six men at risk for aids underwent barium esophagography because of persistent symptoms of esophageal disease. in each case, transmural inflammation of the esophagus was found (esophagomediastinal communication in three cases and esophagobronchial fistulas in three cases). two patients had an esophagoe ... | 1990 | 2326472 |
| the booster effect with repeat tuberculin testing in children and its relationship to bcg vaccination. | one hundred and twenty-seven children, aged 6 months - 14 years, attending a day-care centre in pretoria had two mantoux tuberculin tests performed 8 weeks apart. on initial testing 19.7% of the children had reactions greater than or equal to 10 mm and positive tests were commoner in the older children--who had received bcg vaccination twice. on repeat testing a significant increase in the mean tuberculin reaction size was noted and 13% of the children converted to tuberculin positivity. since a ... | 1990 | 2330523 |
| influence of n substitution on antimycobacterial activity of ciprofloxacin. | ciprofloxacin analogs with various substitutions on the piperazine nitrogen were tested against several mycobacteria. in contrast to what has been found with other gram-positive and gram-negative bacteria, alkyl analogs such as n-isopropylciprofloxacin were shown to be significantly more active than ciprofloxacin. mics of 0.125 microgram/ml against mycobacterium tuberculosis were found. | 1990 | 2334166 |
| molecular characteristics of soluble arthritic collagens. | the molecular characteristics of acid-soluble collagen prepared from animals rendered adjuvant arthritis and matched controls have been thoroughly investigated. the arthritic process was induced in rats by the injection of paraffin oil containing the suspension of heat-killed mycobacterium tuberculosis at the dorsum of the tail root. in comparison to the normal, the arthritic collagens consistently demonstrated increased solubility of reconstituted fibrils and marked decrease in intrinsic viscos ... | 1990 | 2341163 |
| racial differences and mycobacterium tuberculosis infection. | | 1990 | 2342528 |
| trna genes in mycobacteria: organization and molecular cloning. | dnas from nine mycobacteria cleaved with restriction endonucleases were hybridized with cdna probes synthesized to trnas from mycobacterium tuberculosis and mycobacterium smegmatis. the trna genes are conserved, but their gross genomic organization has diverged in six of the nine species examined. organisms of the m. tuberculosis h37ra and h37rv-m. bovis bcg complex appeared to have identical trna gene organization and were indistinguishable from each other. m. tuberculosis and m. smegmatis trna ... | 1990 | 2345129 |
| tuberculosis of the female genital tract in patients attending an infertility clinic. | mycobacterium tuberculosis plays a major role in infertility, which is the commonest symptom of genital tuberculosis in women. from august 1987 to july 1988, 109 women presenting with infertility were investigated for tuberculosis. none had any other symptoms or signs of the disease. in all cases it was diagnosed by culture of m. tuberculosis in one or more of the 5 specimens (3 menstrual fluid specimens, endometrial tissue and peritoneal fluid) obtained from each woman. in addition ziehl-neelse ... | 1990 | 2345881 |
| release of a mitogenic factor by splenic lyt 1+ t-cells from mice treated with ssm, an immunomodulator extracted from human type tubercle bacilli. | a production of the soluble factor activity in culture fluids of murine splenic mononuclear cells (smnc) treated with ssm, an immunopotentiator extracted from mycobacterium tuberculosis strain aoyama b, was investigated. the soluble factor activity was determined as a mitogenic activity released from smnc of mice previously treated with a 500 micrograms/kg dose of ssm (primed smnc). the mitogenic activity was produced when primed smnc were challenged in vitro with ssm at a concentration of 5 mic ... | 1990 | 2346302 |
| [granulomatous inflammation with combined immunodeficiency]. | pulmonary infection with mycobacterium tuberculosis and clonal b-cell expansion is described in a 26-year-old woman with granulomatous disease of lung, liver, and bone marrow as well as a late onset common variable immunodeficiency syndrome (cvid). | 1990 | 2351411 |
| rapid diagnosis of tuberculous meningitis by frequency-pulsed electron-capture gas-liquid chromatography detection of carboxylic acids in cerebrospinal fluid. | the frequency-pulsed electron-capture gas-liquid chromatography technique described previously by brooks et al. was modified and applied to the studies of coded and routine clinical specimens. uncentrifuged cerebrospinal fluid (2 ml) was extracted under acidic conditions, derivatized, and analyzed by frequency-pulsed electron-capture gas-liquid chromatography on large-bore fused silica polar and nonpolar capillary columns. the frequency-pulsed electron-capture gas-liquid chromatography profile o ... | 1990 | 2351743 |
| experimental immune mediated arthritis in rhesus monkeys. a model for human rheumatoid arthritis? | the induction of experimental arthritis in rhesus monkeys was studied by intradermal immunization of bovine type ii collagen and antigens derived from mycobacterium tuberculosis, streptococcus pyogenes, and eubacterium aerofaciens. the tested bacterial antigens proved to be not arthrogenic. bovine type ii collagen induced clinical arthritis in 50% of the rhesus monkeys. type ii collagen induced arthritis in rhesus monkeys proved to be a potential model to study clinical, serological, histologica ... | 1990 | 2353150 |
| induction of interleukin 3 and tumor resistance by ssm, a cancer immunotherapeutic agent extracted from mycobacterium tuberculosis. | interleukin 3 (il-3) activity was demonstrated when inguinal lymph node cells obtained from bacillus calmette-guérin-sensitized mice (bcg-ilnc) were stimulated in vitro with ssm, an immunomodulator extracted from mycobacterium tuberculosis. the il-3 activity was first detected on day 1 in culture fluids of bcg-ilnc stimulated with ssm, reached a peak on day 3, and then gradually decreased. the activity was completely neutralized by treatment with anti-murine il-3 monoclonal antibody (mab). when ... | 1990 | 2354453 |
| [identification of mycobacterium avium complex isolated in tokyo university hospital using dna probe procedure]. | mycobacteria other than mycobacterium tuberculosis isolated in tokyo university hospital during 1970-1980 were identified to the level of species using a commercial dna probe kit (gen-probe rapid diagnostic system for mycobacterium avium complex; gen-probe corp., california, usa). the cell count to give a positive result, that is, the absolute hybridization of more than 10%, was 5 x 10(6) cfu/ml for m. avium and 1 x 10(6) cfu/ml for m. intracellulare, respectively. at this condition, compared wi ... | 1990 | 2358709 |
| [clinico-pathogenetic observations on the subject of "superficial vasculitis"]. | a clinical, histopathologic, laboratory and therapeutic study in 44 subjects with "superficial vasculitis", consecutively observed during the last two years, has been carried out. the findings showed that 1. the anamnesis was sometimes not relevant; 2. the clinical pictures were not in a regular manner correlated with histologic reports (a polymorphonuclear infiltrate with leukocytoclasis or a lymphomononuclear + one); and 3. a non-correlation between clinical, histologic and etiologic data. inf ... | 1990 | 2365404 |
| genus- and species-specific dna probes to identify mycobacteria using the polymerase chain reaction. | differential diagnosis of mycobacterium tuberculosis, m. avium, and other mycobacteria remains a lengthy process. recently, the use of dna probes has been proposed as a new approach for a more specific and rapid diagnosis. here, we report the cloning and sequencing of a genus-specific probe for mycobacterium and a species-specific m. avium probe. the genus-specific probe hybridizes with dna from nine atcc type strains and 13 isolates of mycobacteria but not to non-mycobacterial dna. in addition, ... | 1990 | 2366764 |
| the incidence and epidemiology of human immunodeficiency virus infection in 320 patients treated in an inner-city hemodialysis center. | from january 1, 1986 through june 30, 1989, 320 maintenance hemodialysis patients treated at the brookdale hospital medical center were tested for the presence of antibody to the human immunodeficiency virus (hiv) using the enzyme-linked immunosorbent assay (elisa) and western blot assays. thirty-nine patients (12%) tested positive for hiv antibody (hiv+) with both the elisa and western blot, 24 (62%) of whom were known intravenous drug abusers (ivda). of the remaining non-ivda patients, unantic ... | 1990 | 2368703 |
| [a resected case of mediastinal tuberculous lymphadenitis with pericostal tuberculosis]. | a case of 22-year-old female with mediastinal tuberculous lymphadenitis and pericostal tuberculosis was reported. her complaint was right chest pain and subcutaneous mass on the right chest wall. chest contrast ct showed right paratracheal lymph node swelling with central low density area and surrounding rim enhancement, which has been reported as typical characteristics of mediastinal tuberculous lymphadenitis. pigeon-egg sized subcutaneous mass with fluctuation was palpable on the right sterna ... | 1990 | 2376934 |
| [effects of cotrimoxazole on some macrophage functions: microbicide, tumoricide, production of free oxygen radicals, prostaglandins and leukotrienes]. | in order to demonstrate an immunomodulating effect of cotrimoxazole, we investigated its influence on some macrophage (m phi) functions in culture: p815 tumor cells killing, toxoplasma gondii killing, production of free oxygen radicals by luminol-dependent chemiluminescence, prostaglandins and leukotrienes secretion evaluated after incorporation of tritiated arachidonic acid. in vitro, cotrimoxazole inhibited in a dose-dependent fashion the chemiluminescence of murine resident peritoneal or guin ... | 1990 | 2377390 |
| prospective study of mycobacterial infections in patients with cystic fibrosis. | fifty four patients with cystic fibrosis, aged 3-67 years, were studied prospectively for pulmonary mycobacterial infection. sputum smears and cultures were carried out and intradermal skin tests performed. mycobacteria were cultured from six patients in association with clinical deterioration; four patients had positive direct smears. mycobacterium tuberculosis, m aviumintracellulare, m kansasii, and m gordonae were isolated. there were no deaths and all improved with chemotherapy. a third of t ... | 1990 | 2382245 |
| esophageal perforation in a patient with acquired immunodeficiency syndrome. | infection with mycobacterium tuberculosis is frequently found in patients with acquired immunodeficiency syndrome and can result in diffuse lymphadenopathy from disseminated disease. a case is presented of esophageal erosion and perforation secondary to mediastinal lymph node enlargement from mycobacterium tuberculosis in a patient positive for human immunodeficiency virus. emergent surgical intervention required resection of the perforated esophagus, end-cervical esophagostomy, gastrostomy, and ... | 1990 | 2383120 |
| changing concepts in spinal epidural abscess: a report of 29 cases. | a review of our recent experience with spinal epidural abscess (sea) reveals several important changing concepts in diagnosis, etiology, management, and outcome. all cases of sea seen by our service from august 1975 to july 1989 were reviewed retrospectively, and 29 patients were identified (19 men and 10 women, aged 13-78 years). abscesses were located in the lumbar (n = 21), thoracic (n = 7), and cervical (n = 1) epidural spaces. gram-positive organisms were the infectious agent in 72% of the ... | 1990 | 2385334 |
| miliary tuberculosis: epidemiology, clinical manifestations, diagnosis, and outcome. | during the early 1970s, attention was called to the changing demographics and poor prognosis of patients with miliary tuberculosis. thirty-eight non-aids patients with miliary tuberculosis seen since 1975 are reviewed. their average age was 60 years. two-thirds of the patients had comorbid conditions. presenting symptoms were nonspecific; fever, anorexia, sweats, and weight loss were the most frequent. fever, tachypnea, rales, and altered mental status were the most commonly associated signs. ch ... | 1990 | 2385765 |
| in vitro production of tumour necrosis factor and prostaglandin e2 by peripheral blood mononuclear cells from tuberculosis patients. | we investigated the production of tumour necrosis factor-alpha (tnf-alpha) and prostaglandin e2 (pge2) by peripheral blood mononuclear cells (pbmc) from tuberculosis patients and healthy controls. pbmc from tuberculosis patients generated constitutively more tnf-alpha than did control pbmc. this production was significantly higher for patients with high-grade fever and cachexia. the increase of tnf-alpha production by pbmc from tuberculosis patients was associated with a comparatively weaker ele ... | 1990 | 2387094 |
| evaluation of a new biphasic culture system for the recovery of mycobacteria. | a newly developed biphasic culture system (mb-check) for recovery of mycobacteria was evaluated. the biphasic system consists of a bottle containing selective modified middlebrook 7h9 broth and a mounted dip slide with chocolate agar and modified middlebrook 7h11 agar with and without nap. the system was compared with culture on two egg-based media, lowenstein medium and a selective gottsacker medium, using 995 routine specimens and 90 artificially seeded sputa. mycobacterium tuberculosis was de ... | 1990 | 2387296 |
| the emerging aids epidemic in ireland--clinicopathological findings in 23 early cases. | a longitudinal study with follow up to the end of 1989 was carried out on 23 patients with aids who had attended st. james's hospital, dublin, by the end of 1987. until then only 33 cases of aids had been reported in ireland. the patients, all of whom had antibodies to human immunodeficiency virus (hiv), were predominantly male, young (mean age 31.3 years) and belonged about equally to three major risk groups: homosexuals, intravenous drug abusers (ivda) and haemophiliacs. aids was diagnosed bec ... | 1990 | 2391209 |
| carrier effect of concanavalin a-reactive and -non-reactive material in tuberculin ppd. | tuberculin purified protein derivative (ppd) is a very potent t-cell reactive material in tuberculin-positive individuals, but the components responsible for this reactivity have not been adequately defined. three purified mycobacterial proteins (mpb70, the bcg 65-kda protein, and bcg antigen 85b) with different degrees of temperature sensitivity were iodine-labelled and added to bcg culture fluid, and the mixtures were autoclaved at 120 degrees c for 30 min to simulate the initial heating proce ... | 1990 | 2402595 |
| bacteremias caused by selenomonas artemidis and selenomonas infelix. | we report two different cases of bacteremia caused by two recently described selenomonas species, selenomonas artemidis and selenomonas infelix. both species are normally found in human buccal flora. s. artemidis bacteremia appeared in a patient (number 1) who presented with an air-fluid pulmonary cavity and clinical conditions consistent with an anaerobic lung abscess. while the patient improved with antibiotic therapy, cultures of respiratory secretions yielded mycobacterium tuberculosis. this ... | 1990 | 2405009 |
| induction and therapy of autoimmune diabetes in the non-obese diabetic (nod/lt) mouse by a 65-kda heat shock protein. | insulin-dependent diabetes mellitus is caused by autoimmune destruction of the insulin-producing beta cells of the pancreas. the results described here indicate that a beta-cell target antigen in non-obese diabetic (nod/lt) mice is a molecule cross-reactive with the 65-kda heat shock protein (hsp65) of mycobacterium tuberculosis. the onset of beta-cell destruction is associated with the spontaneous development of anti-hsp65 t lymphocytes. subsequently hsp65 cross-reactive antigen becomes detecta ... | 1990 | 2406723 |
| antigen-dependent heterogeneity of human migration inhibitory factor. | human migration inhibitory factor (mif) produced by peripheral blood mononuclear cells stimulated with purified protein derivative, tetanus toxoid, streptokinase-streptodornase, or candida albicans antigen was analyzed by gel filtration and isoelectrofocusing. in all cases, supernatants harvested after a 24-hr exposure of the mononuclear cells to the antigen yielded only one mif species with an isoelectric point of 5. in contrast, isoelectrofocusing of supernatants obtained from cells exposed to ... | 1985 | 2408769 |
| demonstration of a shared epitope among mycobacterial antigens using a monoclonal antibody. | an igm monoclonal antibody designated tb-c-1 which is broadly reactive with mycobacteria has been studied to characterize the antigens with which it reacts. enzyme linked immunosorbent assay (elisa) demonstrated reactivity not only with culture filtrates of several mycobacterial species but with several purified antigens of mycobacterium tuberculosis, including protein antigens 5 and 6 and polysaccharides arabinogalactan and arabinomannan. immunoblotting demonstrated reactivity with four distinc ... | 1985 | 2408799 |
| immunoassays of field isolates of mycobacterium bovis and other mycobacteria by use of monoclonal antibodies. | antigen extracts obtained by sonication of 22 strains of mycobacterium bovis from cattle and badgers together with extracts of strains of m. tuberculosis, m. paratuberculosis, m. avium, m. africanum, m. kansasi, m. leprae and bcg were examined with a panel of 10 monoclonal antibodies to m. tuberculosis or m. leprae. antigen extracts were coated in aqueous solution (wet coating) and the extracts were also dried on to the polyvinyl plates (dry coating). when dry coating was compared to wet coating ... | 1985 | 2409287 |
| fine needle aspiration biopsy in the diagnosis of tuberculosis. | bacteriologic data and aspiration smears obtained by fine needle aspiration (fna) biopsy for a series of 39 cases of tuberculosis were reviewed. based on the morphologic features of the aspiration smears, the cases were divided into two groups: 18 cases in which distinct epithelioid granulomas were present and 21 in which no granulomas were found but large amounts of necrotic debris with variable numbers of polymorphonuclear cells, histiocytes and lymphocytes were present. material from the fna ... | 1985 | 2413676 |
| [mechanisms of the action of drugs in the short-course chemotherapy]. | | 1985 | 2416374 |
| [response to the short-course chemotherapy in patients presenting initial resistance]. | | 1985 | 2416375 |
| staining of mycobacterium leprae in epoxy resin sections. | | 1986 | 2419364 |
| influence of initial drug resistance on the response to short-course chemotherapy of pulmonary tuberculosis. | the response to short-course chemotherapy of patients with pulmonary tuberculosis caused by drug-resistant mycobacterium tuberculosis was examined in 12 controlled trials carried out during the past decade in africa, hong kong, and singapore. among those with initial resistance to isoniazid and/or streptomycin, failures during chemotherapy were encountered in 17% of 23 patients given a 6-month regimen of isoniazid and rifampin and in 12% of 264 patients given rifampin only in an initial 2-month ... | 1986 | 2420242 |
| interspecies reactivity of five monoclonal antibodies to mycobacterium tuberculosis as examined by immunoblotting and enzyme-linked immunosorbent assay. | five different murine monoclonal antibodies (mabs) to mycobacterium tuberculosis were examined for degree of cross-reactivity with other mycobacterial species by enzyme-linked immunosorbent assay and immunoblotting. one mab reacted solely with m. tuberculosis and m. bovis bcg. two of the mabs reacted with all mycobacterial species examined, whereas two mabs demonstrated a limited reactivity pattern. the epitopes are located on molecules susceptible to protease treatment, and two of these molecul ... | 1986 | 2420818 |
| [effect of terrilytin on tissue bacteriostatic activity in the chemotherapy of renal and female genital tuberculosis in an experiment]. | the effect of terrilytin on the bacteriostatic activity of the tissues (bat) under conditions of antibacterial therapy was studied on experimental models of tuberculosis of the kidneys and female genitalia in 46 rabbits. it was shown statistically that terrilytin promoted an increase in the bat and might be used as an agent increasing the effect of antibacterial therapy of tuberculosis. the level of the increase of the bat depended on its initial level which was inversely proportional to the lev ... | 1986 | 2424365 |
| [comparative evaluation of bacterioscopic and bacteriological methods for detecting bacterial excretion in newly diagnosed patients with destructive pulmonary tuberculosis]. | | 1986 | 2425141 |