| improvement of 7α-methoxycephalosporins production by overexpression of cmcj and cmci controlled by promoter ermep* in streptomyces clavuligerus. | this study aimed to improve the efficiency of bioconversion of cephalosporin c to 7α-methoxycephalosporin c. | 2014 | 25179172 |
| relation of strain by feature tracking and clinical outcome in children, adolescents, and young adults with hypertrophic cardiomyopathy. | evaluation of hypertrophic cardiomyopathy (hc) in young patients is limited by lack of age-specific norms for wall thickness on cardiovascular magnetic resonance (cmr) images. left ventricular strain may have a role in identifying and risk stratifying patients with hc, but few data exist for strain measurement on cmr images. in 30 patients (14.1 ± 3.2 years) with clinically diagnosed hc and 24 controls (15.6 ± 2.8 years), strain (radial, longitudinal, and circumferential) was evaluated by 2 expe ... | 2014 | 25159233 |
| should electric fans be used during a heat wave? | heat waves continue to claim lives, with the elderly and poor at greatest risk. a simple and cost-effective intervention is an electric fan, but public health agencies warn against their use despite no evidence refuting their efficacy in heat waves. a conceptual human heat balance model can be used to estimate the evaporative requirement for heat balance, the potential for evaporative heat loss from the skin, and the predicted sweat rate, with and without an electrical fan during heat wave condi ... | 2015 | 25134988 |
| biomechanical strain vehicles for fibroblast-directed skeletal myoblast differentiation and myotube functionality in a novel coculture. | skeletal muscle functionality is governed by multiple stimuli, including cytokines and biomechanical strain. fibroblasts embedded within muscle connective tissue respond to biomechanical strain by secreting cytokines that induce myoblast differentiation and, we hypothesize, regulate myotube function. a coculture was established to allow cross talk between fibroblasts in bioflex wells and myoblasts on nondeformable coverslips situated above bioflex wells. cyclic short-duration strain (csds) model ... | 2014 | 25122874 |
| the pathway-specific regulatory genes, tei15* and tei16*, are the master switches of teicoplanin production in actinoplanes teichomyceticus. | pathogenic antibiotic-resistant bacteria are an unprecedented threat to health care worldwide. the range of antibiotics active against these bacteria is narrow; it includes teicoplanin, a "last resort" drug, which is produced by the filamentous actinomycete actinoplanes teichomyceticus. in this report, we determine the functions of tei15* and tei16*, pathway-specific regulatory genes that code for strr- and luxr-type transcriptional factors, respectively. the products of these genes are master s ... | 2014 | 25104028 |
| [acceptance of tinnitus: validation of the ‛akzeptanzfragebogen bei chronischem tinnitus' (afct)]. | tinnitus is a widely spread symptom, which is perceived chronically by approximately 10% of the population. the vast majority of the tinnitus patients doesn´t feel impaired through the ear noise, but about 5-30% of the tinnitus patient are suffering in their everyday life. whether severe distress is experienced cannot be explained by the quality of the ear noise itself (i. e. loudness or duration). newer research tends to explain the difference in the experienced strain by the concept of accepta ... | 2014 | 25098720 |
| left atrial deformation predicts pulmonary capillary wedge pressure in pediatric heart transplant recipients. | pulmonary capillary wedge pressure (pcwp) is an important indicator in pediatric heart transplant patients, but commonly used noninvasive surrogates, such as ratio of early diastolic mitral inflow velocity to annular velocity (e/e'), have limitations in this population. this study aimed to evaluate the relation of left atrial (la) peak systolic strain and distensibility with pcwp in pediatric heart transplant recipients. | 2015 | 25039265 |
| relationship between acute strain pattern and recovery in tako-tsubo cardiomyopathy and acute anterior myocardial infarction: a comparative study using two-dimensional longitudinal strain. | after acute-anterior myocardial infarction (ami), left ventricular (lv) viable myocardial segments show some degree of active deformation (longitudinal shortening) despite wall motion abnormalities (wma). tako-tsubo cardiomyopathy (ttc) is characterized by myocardial stunning; however, it is unclear whether in ttc the strain pattern mimics ami. to compare the strain-pattern in ttc and ami using the 2d-longitudinal strain by speckle-tracking in segments with wma, and its relationship with recover ... | 2014 | 25037469 |
| tilt boundary induced heteroepitaxy in chemically grown dendritic silver nanostructures on germanium and their optical properties. | dendritic silver nanostructures were prepared by a simple dip-and-rinse galvanic displacement reaction directly on germanium surfaces. the formation and evolution of these dendrites were investigated using scanning electron microscopy (sem), high-resolution transmission electron microscopy (hrtem) and energy-dispersive x-ray spectroscopy (edx). the present results clearly show a new type of heteroepitaxy, where the large lattice mismatch between silver and germanium is accommodated at the interf ... | 2014 | 25000224 |
| left ventricular myocardial strain by three-dimensional speckle-tracking echocardiography in healthy subjects: reference values and analysis of their physiologic and technical determinants. | despite growing interest in applying three-dimensional (3d) speckle-tracking echocardiography (ste) to measure left ventricular (lv) myocardial deformation in various diseases, normative values for 3d speckle-tracking echocardiographic parameters and the effects of demographic, hemodynamic, and technical factors on these values are unknown. | 2014 | 24975996 |
| right ventricular strain in pulmonary arterial hypertension: a 2d echocardiography and cardiac magnetic resonance study. | right ventricular (rv) strain is a potentially useful prognostic marker in patients with pulmonary arterial hypertension (pah). however, published reports regarding the accuracy of two-dimensional echocardiography (2de)-derived rv strain against an independent reference in this patient population are limited. the aims of this study were: (1) to study the relationship between 2de rv longitudinal strain and cardiovascular magnetic resonance (cmr)-derived rv ejection fraction (rvef) in patients wit ... | 2015 | 24975738 |
| ipsc-derived human mesenchymal stem cells improve myocardial strain of infarcted myocardium. | we investigated global and regional effects of myocardial transplantation of human induced pluripotent stem cell (ipsc)-derived mesenchymal stem cells (imscs) in infarcted myocardium. acute myocardial infarction (mi) was induced by ligation of left coronary artery of severe combined immunodeficient mice before 2 × 10(5) imscs or cell-free saline were injected into peri-infarcted anterior free wall. sham-operated animals received no injection. global and regional myocardial function was assessed ... | 2014 | 24974908 |
| amino acid substitutions and intron polymorphism of acetylcholinesterase1 associated with mevinphos resistance in diamondback moth, plutella xylostella (l.). | the diamondback moth, plutella xylostella l., is the most destructive insect pest of brassica crops in the world. it has developed resistance rapidly to almost every insecticide used for its control. mevinphos, a fast degrading and slow resistance evocating organophosphorus insecticide, has been recommended for controlling p. xylostella in taiwan for more than 40years. shm strain of p. xylostella, with ca. 22-fold resistance to this chemical, has been established from a field sh strain by select ... | 2014 | 24974111 |
| [management of aortic valvular heart disease according to the 2012 guidelines]. | in 2012, the european society of cardiology (esc) published an updated version of its guidelines on the management of valvular heart disease. novelties include the use of advanced techniques for risk stratification and prognostic evaluation, such as stress and 3d echocardiography as well as measurement of left ventricular strain by speckle tracking. equally important is the inclusion of percutaneous valve replacement or repair procedures, reflecting their ever-increasing use in clinical practice ... | 2014 | 24964523 |
| [duration of inability for work and return to physical work after arthroscopic and open labrum refixation]. | the duration of inability for work according to work load and the rate of successful return to work after open and arthroscopic bankart repair (br) due to anterior shoulder dislocation has not yet been examined with regard to validated work strain by the refa classification. thus, the objective of this study was to determine the duration of inability to work according to work load (refa criteria) after open and arthroscopic br as well as the rate of successful return to the original occupation. | 2014 | 24960094 |
| left atrial expansion index is an independent predictor of diastolic dysfunction in patients with preserved left ventricular systolic function: a three dimensional echocardiography study. | in the absence of mitral valve disease left atrial (la) volume is a marker of diastolic dysfunction and its severity. this study investigated the relationship between left ventricular (lv) end diastolic pressure (lvedp) and la volumes and phasic atrial functions detected by real-time full volume three-dimensional echocardiography (rt3de), in a patient population with preserved lv systolic function. seventy-two (39 female and 33 male; mean age 56.1 ± 9.0 years) stable patients with normal lv ejec ... | 2014 | 24958524 |
| resistance to noise-induced hearing loss in 129s6 and molf mice: identification of independent, overlapping, and interacting chromosomal regions. | noise-induced hearing loss (nihl) is a prevalent health risk. inbred mouse strains 129s6/svevtac (129s6) and molf/eij (molf) show strong nihl resistance (nr) relative to cba/caj (cbaca). in this study, we developed quantitative trait locus (qtl) maps for nr. we generated f1 animals by intercrossing (129s6 × cbaca) and (molf × cbaca). in each intercross, nr was recessive. n2 animals were produced by backcrossing f1s to their respective parental strain. the 232 n2-129s6 and 225 n2-molf progenies w ... | 2014 | 24952082 |
| cardiovascular adaptations to 4 and 12 months of football or strength training in 65- to 75-year-old untrained men. | the study examined the effects of 1 year of football or strength training on cardiovascular function in 65- to 75-year-old men. twenty-six untrained men (age: 68.2 ± 3.2 years) were randomized to football training (ftg; n = 9), strength training (stg; n = 9), or control (cg; n = 8). in ftg, left ventricular (lv) internal diastolic diameter, end-diastolic volume, and mass index were 8%, 21%, and 18% higher (p < 0.01), respectively, after 12 months, with no changes in stg and cg. after 12 months, ... | 2014 | 24902992 |
| relationship between pulse pressure variation and echocardiographic indices of left ventricular filling pressure in critically ill patients. | pulse pressure variation (ppv) is a dynamic index of fluid responsiveness. this parameter helps clinicians in improving haemodynamic status while avoiding potential fluid overload. echocardiographic indices, such as e/e' ratio and left atrial (la) strain by speckle tracking echocardiography (ste), are used to estimate left ventricular (lv) filling pressures. this study aimed at exploring the relationship between ppv and echocardiographic indices of lv filling pressures in critically ill patients ... | 2015 | 24902871 |
| multiplane two-dimensional strain echocardiography for segmental analysis of right ventricular mechanics: new-rv study. | recent studies showed the prognostic value of strain measurements of the free right ventricular (rv) wall. the aim of this study was to evaluate the feasibility and the diagnostic value of the assessment of longitudinal mechanics of all segments of the rv by multiplane, two-dimensional transthoracic (2d) strain echocardiography. | 2014 | 24830514 |
| tuning nanoparticle structure and surface strain for catalysis optimization. | controlling nanoparticle (np) surface strain, i.e. compression (or stretch) of surface atoms, is an important approach to tune np surface chemistry and to optimize np catalysis for chemical reactions. here we show that surface pt strain in the core/shell fept/pt nps with pt in three atomic layers can be rationally tuned via core structural transition from cubic solid solution [denoted as face centered cubic (fcc)] structure to tetragonal intermetallic [denoted as face centered tetragonal (fct)] ... | 2014 | 24803093 |
| strain measurement by cardiovascular magnetic resonance in pediatric cancer survivors: validation of feature tracking against harmonic phase imaging. | left ventricular strain may be a more sensitive marker of left ventricular dysfunction than ejection fraction in pediatric cancer survivors after anthracycline therapy, but there is limited validation of strain measurement by feature tracking on cardiovascular magnetic resonance (mr) images. | 2014 | 24760125 |
| evolutionarily diverged regulation of x-chromosomal genes as a primal event in mouse reproductive isolation. | improper gene regulation is implicated in reproductive isolation, but its genetic and molecular bases are unknown. we previously reported that a mouse inter-subspecific x chromosome substitution strain shows reproductive isolation characterized by male-specific sterility due to disruption of meiotic entry in spermatogenesis. here, we conducted comprehensive transcriptional profiling of the testicular cells of this strain by microarray. the results clearly revealed gross misregulation of gene exp ... | 2014 | 24743563 |
| a microdot multilayer oxide device: let us tune the strain-ionic transport interaction. | in this paper, we present a strategy to use interfacial strain in multilayer heterostructures to tune their resistive response and ionic transport as active component in an oxide-based multilayer microdot device on chip. for this, fabrication of strained multilayer microdot devices with sideways attached electrodes is reported with the material system gd0.1ce0.9o(2-δ)/er2o3. the fast ionic conducting gd0.1ce0.9o(2-δ) single layers are altered in lattice strain by the electrically insulating erbi ... | 2014 | 24720562 |
| sublattice localized electronic states in atomically resolved graphene-pt(111) edge-boundaries. | understanding the connection of graphene with metal surfaces is a necessary step for developing atomically precise graphene-based technology. combining high-resolution stm experiments and dft calculations, we have unambiguously unveiled the atomic structure of the boundary between a graphene zigzag edge and a pt(111) step. the graphene edges minimize their strain by inducing a 3-fold edge-reconstruction on the metal side. we show the existence of an unoccupied electronic state that is mostly loc ... | 2014 | 24654926 |
| oxidative stress is a mediator for increased lipid accumulation in a newly isolated dunaliella salina strain. | green algae offer sustainable, clean and eco-friendly energy resource. however, production efficiency needs to be improved. increasing cellular lipid levels by nitrogen depletion is one of the most studied strategies. despite this, the underlying physiological and biochemical mechanisms of this response have not been well defined. algae species adapted to hypersaline conditions can be cultivated in salty waters which are not useful for agriculture or consumption. due to their inherent extreme cu ... | 2014 | 24651514 |
| relation of functional echocardiographic parameters to infarct scar transmurality by magnetic resonance imaging. | identification of viable but dysfunctional myocardium after myocardial infarction is important for management, including the decision for revascularization. assessment of infarct transmurality (trm) by late contrast enhancement on magnetic resonance imaging (mri) is frequently used for this task but has several limitations, particularly its availability. the goal of this study was to compare the value of several simple echocardiographic parameters measured at rest at the bedside for the identifi ... | 2014 | 24651003 |
| early assessment of strain echocardiography can accurately exclude significant coronary artery stenosis in suspected non-st-segment elevation acute coronary syndrome. | many patients with suspected non-st-segment elevation acute coronary syndrome (nste-acs) do not have significant coronary artery disease. the current diagnostic approach of repeated electrocardiography and cardiac biomarker assessment requires observation for >6 to 12 hours. this strategy places a heavy burden on hospital facilities. the objective of this study was to investigate whether myocardial strain assessment by echocardiography could exclude significant coronary artery stenosis in patien ... | 2014 | 24612899 |
| [study on the axial strain sensor of birefringence photonic crystal fiber loop mirror based on the absolute integral of the monitoring peak]. | in the present paper, the theoretical expression of the wavelength change and the axial strain of birefringence fiber loop mirror is developed. the theoretical result shows that the axial strain sensitivity of birefringence photonic crystal fiber loop mirror is much lower than conventional birefringence fiber loop mirror. it is difficult to measure the axial strain by monitoring the wavelength change of birefringence photonic crystal fiber loop mirror, and it is easy to cause the measurement err ... | 2013 | 24611385 |
| preclinical impairment of myocardial function in rheumatoid arthritis patients. detection of myocardial strain by speckle tracking echocardiography. | the incidence of heart failure is higher in patients with rheumatoid arthritis (ra) than in the general population and contributes to elevated cardiovascular mortality and morbidity rates. impaired myocardial function can be detected by a novel echocardiographic method, speckle tracking echocardiography (ste), when conventional methods have yielded normal findings. the aim of our study was to investigate the effect of disease duration on myocardial strain and strain rate parameters in patients w ... | 2015 | 24595319 |
| objective factors associated with physicians' and nurses' perceptions of intensive care unit capacity strain. | time-varying demand for critical care may strain the capacities of intensive care units (icus) to provide optimal care. intensivists and icu nurses may be the best judges of the strain on their icu. yet, it is not clear what icu and hospital factors contribute to this perceived sense of strain among icu providers. | 2014 | 24575984 |
| immune cell trafficking from the brain maintains cns immune tolerance. | in the cns, no pathway dedicated to immune surveillance has been characterized for preventing the anti-cns immune responses that develop in autoimmune neuroinflammatory disease. here, we identified a pathway for immune cells to traffic from the brain that is associated with the rostral migratory stream (rms), which is a forebrain source of newly generated neurons. evaluation of fluorescently labeled leukocyte migration in mice revealed that dcs travel via the rms from the cns to the cervical lns ... | 2014 | 24569378 |
| left ventricular longitudinal strain by speckle-tracking echocardiography is associated with treatment-requiring cardiac allograft rejection. | noninvasive detection of rejection is a major objective in the management of heart transplant recipients. | 2014 | 24561182 |
| treatment of submassive pulmonary embolism with tenecteplase or placebo: cardiopulmonary outcomes at 3 months: multicenter double-blind, placebo-controlled randomized trial. | acute pulmonary embolism (pe) can worsen quality of life due to persistent dyspnea or exercise intolerance. | 2014 | 24484241 |
| left ventricular function can be continuously monitored with an epicardially attached accelerometer sensor. | preservation of left ventricular (lv) function is crucial for a beneficial outcome in high-risk patients undergoing cardiac surgery. the present study evaluated a motion sensor (accelerometer) for continuous monitoring of lv performance during changes in global and regional lv function. | 2014 | 24482390 |
| relation of aortic stiffness and strain by cardiovascular magnetic resonance imaging to age in repaired tetralogy of fallot. | patients with tetralogy of fallot (tof) have abnormal aortic properties. it is not known if this increases the risk for aneurysm formation. we sought to identify clinical and cardiovascular magnetic resonance (cmr) imaging patient characteristics associated with worsened aortic pulse wave velocity (pwv) and aortic strain in patients with repaired tof. in 124 patients with tof undergoing cmr (median age 24.6 years, interquartile range 17.8 to 34.2), left and right ventricular volumetric data, aor ... | 2014 | 24480147 |
| feature tracking compared with tissue tagging measurements of segmental strain by cardiovascular magnetic resonance. | left ventricular segmental wall motion analysis is important for clinical decision making in cardiac diseases. strain analysis with myocardial tissue tagging is the non-invasive gold standard for quantitative assessment, however, it is time-consuming. cardiovascular magnetic resonance myocardial feature-tracking (cmr-ft) can rapidly perform strain analysis, because it can be employed with standard cmr cine-imaging. the aim is to validate segmental peak systolic circumferential strain (peak scs) ... | 2014 | 24450803 |
| drawing a high-resolution functional map of adeno-associated virus capsid by massively parallel sequencing. | adeno-associated virus (aav) capsid engineering is an emerging approach to advance gene therapy. however, a systematic analysis on how each capsid amino acid contributes to multiple functions remains challenging. here we show proof-of-principle and successful application of a novel approach, termed aav barcode-seq, that allows us to characterize phenotypes of hundreds of different aav strains in a high-throughput manner and therefore overcomes technical difficulties in the systematic analysis. i ... | 2014 | 24435020 |
| [value of 3-dimensional speckle tracking imaging to quantify regional left ventricular function in patients with coronary artery disease]. | to assess left ventricular (lv) strain by 3-dimensional speckle tracking imaging (3d-sti) in patients with coronary heart disease (chd). | 2013 | 24377891 |
| enhancing cellulase and hemicellulase production by genetic modification of the carbon catabolite repressor gene, crea, in acremonium cellulolyticus. | acremonium cellulolyticus is one of several fungi that offer promise as an alternative to trichoderma reesei for use in industrial cellulase production. however, the mechanism of cellulase production has not been studied at the molecular level because adequate genetic engineering tools for use in a. cellulolyticus are lacking. in the present study, we developed a gene disruption method for a. cellulolyticus, which needs a longer homologous region length. we cloned a putative a. cellulolyticus cr ... | 2013 | 24360128 |
| solid-state fermentation for humic acids production by a trichoderma reesei strain using an oil palm empty fruit bunch as the substrate. | empty fruit bunch (efb), an underutilized waste product of oil palm processing, was studied as a substrate for the production of humic acids (ha) by a trichoderma reesei strain by solid-state fermentation (ssf) in raimbault columns. ha have attracted the attention of many investigators due to their applications in agriculture, industry, the environment, and biomedicine. commercial ha are currently chemically extracted from peat and coal, which are nonrenewable carbon sources. biotechnological pr ... | 2014 | 24343369 |
| left ventricular and atrial functions in hypertrophic cardiomyopathy patients with very high lvot gradient: a speckle tracking echocardiographic study. | determination of myocardial deformation (strain) by two-dimensional (2d) speckle tracking echocardiography (ste) is a new method for evaluating left ventricular (lv) regional function in patients with hypertrophic cardiomyopathy (hcm). the aim of this study was to assess lv and left atrial (la) functions with 2dste in hcm patients and to investigate relation between strain analysis and lv outflow tract (lvot) gradient. | 2014 | 24341920 |
| use of three-dimensional speckle-tracking echocardiography for quantitative assessment of global left ventricular function: a comparative study to three-dimensional echocardiography. | the aim of this study was to determine whether global strains derived from three-dimensional (3d) speckle-tracking echocardiography (ste) are as accurate as left ventricular (lv) ejection fraction (lvef) obtained by two-dimensional (2d) and 3d echocardiography in the quantification of lv function. | 2014 | 24325960 |
| stabilization and transformation of asymmetric configurations in small-mismatch alloy nanoparticles: the role of coordination dependent energetics. | chemical order in platinum-iridium truncated-octahedron nanoparticles as a model system was studied using coordination-dependent bond-energy variations (cbev) and the statistical-mechanical free-energy concentration expansion method (fcem) adapted for handling axially symmetric structures. pt-ir side-separated ("quasi-janus", qj) configurations are found to be stabilized at low temperatures mainly due to cbev-related preferential strengthening of pt-surface-ir-subsurface bonds, and the greatly r ... | 2014 | 24306313 |
| visualization of ecdysteroid activity using a reporter gene in the crustacean, daphnia. | ecdysone is a hormone known to play a pivotal role in crustaceans and insects. in order to evaluate the ecdysone activities in the environment and within the organism, we have developed a biomonitoring daphnia strain by introducing a reporter gene. in this study, the ecdysone response element was inserted in the upstream region of a reporter gene, and the dna construct was injected into daphnia eggs. the expression of the reporter gene was detected during the early embryonic development stage. i ... | 2014 | 24296240 |
| antidepressant effects on serotonin 1a/1b receptors in the rat brain using a gene x environment model. | a gene-environment (gxe) interaction is implicated in both the pathophysiology and treatment of major depressive disorder (mdd). this study modeled the effects of genetic vulnerability by using the flinders sensitive line (fsl), a rat model of depression and its control counterpart-the flinders resistant line (frl). the effects of environmental vulnerability (e.g., early-life stress) were modeled by using maternal separation. rats (n=105) were drawn from four groups reflecting experimental cross ... | 2014 | 24287374 |
| 1,3,2-dithiaphospholanes with an annelated 1,2-dicarba-closo-dodecaborane(12) unit: formation and reactivity. | 1,3,2-dithiaphospholanes were prepared, containing an annelated 1,2-dicarba-closo-dodecaborane(12) unit, bearing halogens (f, cl, br, and i), h, net2, oet groups, or organo substituents (r = i-pr, t-bu, cy, 3,5-me2-c6h3-ch2, ph) at phosphorus. the t-bu derivative was structurally characterised as its sulfide. the organo-substituted derivatives escape the ring strain by irreversible (r = t-bu; x-ray analysis) or reversible dimerisation, by which 10-membered rings are formed. using 1,1-bis(dichlor ... | 2014 | 24247274 |
| rationale and methodology for a multicentre randomised trial of fibrinolysis for pulmonary embolism that includes quality of life outcomes. | submassive pulmonary embolism (pe) has a low mortality rate but can degrade functional capacity. | 2013 | 24224521 |
| an integrated microfluidic device utilizing vancomycin conjugated magnetic beads and nanogold-labeled specific nucleotide probes for rapid pathogen diagnosis. | a pcr-free assay for rapid pathogen diagnosis was implemented on an integrated microfluidic system in this study. vancomycin-conjugated magnetic beads were used to capture multiple strains of bacteria and nucleotide probes labeled gold nanoparticles were used to specify and detect a specific strain by hybridization-induced color change. the assay was entirely automated within an integrated microfluidic device that was composed of suction-type micropumps, microvalves, microchannels, and microcham ... | 2014 | 24215722 |
| long axis strain by mri and echocardiography in a postmyocardial infarct population. | to compare long axis strain (las) by magnetic resonance imaging (mri) and echocardiography in a postinfarct patient population. long axis left ventricle (lv) function is a sensitive index of incipient heart failure by echocardiography, but is less well established in mri. las is an index of global lv function, which is easily assessed in cine loops provided by most cardiac mri protocols. | 2014 | 24214923 |
| [rational screen of high kelimycin-producing strain by combined conventional mutagenesis and high-throughput screen method]. | kelimycin, is a new macrolide antibiotic drug obtained through genetic engineering approaches. with 4"-o-isovalerylspiramycins as the major components, was produced by genetically engineered streptomyces spiramyceticus transformed with 4"-o-acyltransferase gene from s. mycarofaciens. | 2013 | 24195383 |
| utility of global strain by two-dimensional and three-dimensional speckle tracking for assessing left ventricular diastolic function: comparison with pressure wire analysis. | we evaluated the utility of two-dimensional (2d) and three-dimensional (3d) left ventricular (lv) global myocardial deformity parameters for assessing lv diastolic function by comparing invasive measures of lv performance. | 2013 | 24174962 |
| biomechanical effect of transforaminal lumbar interbody fusion and axial interbody threaded rod on range of motion and s1 screw loading in a destabilized l5-s1 spondylolisthesis model. | a cadaveric lumbosacral spondylolytic spondylolisthesis model was used to evaluate the biomechanical function of 2 different interbody spacers. | 2014 | 24150429 |
| favorable changes in arterial elasticity, left ventricular mass, and diastolic function after significant weight loss following laparoscopic sleeve gastrectomy in obese individuals. | obesity is accompanied by increased arterial stiffness, left ventricular (lv) hypertrophy, and diastolic dysfunction, all associated with a negative prognosis. the evolution of lv mass, function, and arterial elasticity after laparoscopic sleeve gastrectomy (lsg) was unknown, and this is what we have investigated. | 2014 | 24142422 |
| sign-inverted response of aluminum work function to tangential strain. | we have investigated the response of the work function, w, of low-index aluminum surfaces to tangential strain by using first-principles calculations based on density functional theory. this response parameter is a central quantity in electrocapillary coupling of metal electrodes relating to the performance of porous metal actuators and surface stress based sensing devices. we find that al surfaces exhibit a positive response for all orientations considered. by contrast, previous studies reporte ... | 2013 | 24131930 |
| changes in three-dimensional speckle-tracking-derived myocardial strain during percutaneous coronary intervention. | the aim of this study was to evaluate changes in three-dimensional (3d) speckle-tracking-derived myocardial strain during ischemia. | 2013 | 24125875 |
| a fatigue loading model for investigation of iatrogenic subtrochanteric fractures of the femur. | biomechanics of iatrogenic subtrochanteric femur fractures have been examined. previously-described loading models employed monotonic loading on the femoral head, which is limited in emulating physiological features. we hypothesize that cyclic loading combined with the engagement of abductor forces will reliably cause iatrogenic subtrochanteric fractures. | 2013 | 24125692 |
| risk prediction of ventricular arrhythmias and myocardial function in lamin a/c mutation positive subjects. | mutations in the lamin a/c gene may cause atrioventricular block, supraventricular arrhythmias, ventricular arrhythmias (va), and dilated cardiomyopathy. we aimed to explore the predictors and the mechanisms of va in lamin a/c mutation-positive subjects. | 2014 | 24058181 |
| strain engineering of nanowire multi-quantum well demonstrated by raman spectroscopy. | an analysis of the strain in an axial nanowire superlattice shows that the dominating strain state can be defined arbitrarily between unstrained and maximum mismatch strain by choosing the segment height ratios. we give experimental evidence for a successful strain design in series of gan nanowire ensembles with axial inxga1-xn quantum wells. we vary the barrier thickness and determine the strain state of the quantum wells by raman spectroscopy. a detailed calculation of the strain distribution ... | 2013 | 24001176 |
| limits to sustained energy intake. xxi. effect of exposing the mother, but not her pups, to a cold environment during lactation in mice. | the capacity of females to dissipate heat may constrain sustained energy intake during lactation. however, some previous experiments supporting this concept have confounded the impact of temperature on the mothers with the impact on the pups. we aimed to separate these effects in lactating laboratory mice (mf1 strain) by giving the mothers access to cages at two ambient temperatures (10 and 21°c) joined by a tube. food was available only in the cold cage, but females could also choose go to this ... | 2013 | 23997194 |
| a strained organic field-effect transistor with a gate-tunable superconducting channel. | in state-of-the-art silicon devices, mobility of the carrier is enhanced by the lattice strain from the back substrate. such an extra control of device performance is significant in realizing high-performance computing and should be valid for electric-field-induced superconducting (sc) devices, too. however, so far, the carrier density is the sole parameter for field-induced sc interfaces. here we show an active organic sc field-effect transistor whose lattice is modulated by the strain from the ... | 2013 | 23974634 |
| anti-inflammatory effects of kudingcha methanol extract (ilex kudingcha c.j. tseng) in dextran sulfate sodium-induced ulcerative colitis. | the present study aimed to investigate the anti‑inflammatory effects of ilex kudingcha c.j. tseng methanol extracts (kme) on 3% dextran sulfate sodium (dss)‑induced ulcerative colitis (uc) in mice (c57bl/6j strain). body weight, disease activity index (dai), colon length, colon weight to length ratio, colonic myeloperoxidase (mpo), glutathione (gsh) and malondialdehyde (mda) levels were measured. histological changes were observed by hematoxylin and eosin staining. colonic levels of tumor necros ... | 2013 | 23969782 |
| is strain by speckle tracking echocardiography dependent on user controlled spatial and temporal smoothing? an experimental porcine study. | speckle tracking echocardiography (ste) strain analysis relies on both spatial and temporal smoothing. the user is often allowed to adjust these smoothing parameters during analysis. this experimental study investigates how different degrees of user controllable spatial and temporal smoothing affect global and regional ste strain values in recordings obtained from normal and ischemic myocardium. | 2013 | 23964663 |
| structural elucidation of palytoxin analogs produced by the dinoflagellate ostreopsis ovata ik2 strain by complementary use of positive and negative ion liquid chromatography/quadrupole time-of-flight mass spectrometry. | the ovatoxins are palytoxin analogs of a dinoflagellate origin implicated in human intoxication. the structures of ovatoxin-a, ovatoxin-d, and ovatoxin-e produced by the ik2 strain of ostreopsis ovata collected in japan were elucidated using liquid chromatography/quadrupole time-of-flight mass spectrometry (lc/qtofms). the novel structures and a new insight into the spectral data are presented. | 2013 | 23939968 |
| an ultra-linear piezo-floating-gate strain-gauge for self-powered measurement of quasi-static-strain. | in this paper we describe a self-powered sensor that can be used for in-vivo measurement of the quasi-static-strain and also for in-vivo measurement of the l1 norm of the strain signal. at the core of the proposed design is a linear floating-gate injector that can achieve more than 13 bits of precision in sensing, signal integration and non-volatile storage. the injectors are self-powered by the piezoelectric transducers that convert mechanical energy from strain-variations into electrical energ ... | 2013 | 23893203 |
| regional peak longitudinal-strain by 2d speckle-tracking tte provides useful information to distinguish fibrotic from non-fibrotic lesions in lv myocardium on cardiac mr in hypertrophic cardiomyopathy. | | 2013 | 23876465 |
| detection of novel rotavirus strain by vaccine postlicensure surveillance. | surveillance for rotavirus-associated diarrhea after implementation of rotavirus vaccination can assess vaccine effectiveness and identify disease-associated genotypes. during active vaccine postlicensure surveillance in the united states, we found a novel rotavirus genotype, g14p[24], in a stool sample from a child who had diarrhea. unusual rotavirus strains may become more prevalent after vaccine implementation. | 2013 | 23876297 |
| [identification and function test of an alkali-tolerant denitrifying bacterium]. | we obtained an alkali-tolerant denitrifying bacterium, and determined its denitrifying activity and alkali-tolerance. | 2013 | 23858712 |
| airway-specific inducible transgene expression using aerosolized doxycycline. | tissue-specific transgene expression using tetracycline (tet)-regulated promoter/operator elements has been used to revolutionize our understanding of cellular and molecular processes. however, because most tet-regulated mouse strains use promoters of genes expressed in multiple tissues, to achieve exclusive expression in an organ of interest is often impossible. indeed, in the extreme case, unwanted transgene expression in other organ systems causes lethality and precludes the study of the tran ... | 2013 | 23848320 |
| left ventricular three-dimensional global systolic strain by real-time three-dimensional speckle-tracking in children: feasibility, reproducibility, maturational changes, and normal ranges. | three-dimensional (3d) strain analysis may help overcome the limitations of doppler and two-dimensional strain analysis for the left ventricle and become the method of choice for left ventricular (lv) systolic function. the aims of this study were to evaluate the feasibility and reproducibility of lv global 3d systolic strain by real-time 3d speckle-tracking echocardiography (ste) in children and to establish their maturational growth patterns and normal values. | 2013 | 23791113 |
| quantification of left ventricular longitudinal strain by two-dimensional speckle tracking: a comparison between expert and non-expert readers. | the study aimed to examine whether global and segmental longitudinal strain (ls) using speckle tracking echocardiography could improve the interpretation of wall motion (wm) asynergy for expert and non-expert readers compared to visual assessment by 2-dimensional echocardiography (2de). using the 17 left ventricular segments model, both segmental and global ls were assessed by automatic function imaging in 20 patients with ischemic heart disease (61.0 ± 9.9 years, 70 % are male) and 20 normal co ... | 2013 | 23771748 |
| polymer nanocomposite hydrogels exhibiting both dynamic restructuring and unusual adhesive properties. | polymer nanocomposite (nc) hydrogels exhibiting both dynamic restructuring and unusual adhesive properties in wet and dry states have been prepared in an efficient and straightforward way via free radical polymerization of poly(ethylene glycol) methyl ether acrylate (peg) in the presence of silane-modified sodium montmorillonite (nammt). the dynamic restructuring of the nc gel has been demonstrated by almost instant recovery of mechanical properties, such as storage modulus, loss modulus, and da ... | 2013 | 23721059 |
| phenotypic characterization of c57bl/6j mice carrying the disc1 gene from the 129s6/svev strain. | disruption of disrupted-in-schizophrenia 1 (disc1), a candidate susceptibility gene for schizophrenia, was first identified in a large scottish family in which many members suffered from various psychiatric disorders, including schizophrenia. to model the scottish disc1 truncation, we established a disc1 mutant mouse line in which the 129s6/svev 25-bp deletion variant was transferred into the c57bl/6j strain by backcrossing. a battery of behavioral tasks was conducted to evaluate the basic behav ... | 2014 | 23689501 |
| molecular adaptations of helicoverpa armigera midgut tissue under pyrethroid insecticide stress characterized by differential proteome analysis and enzyme activity assays. | helicoverpa armigera is an insect that causes important economic losses in crops. to reduce this loss, pyrethroids have been commonly used against h. armigera in farming areas. however, excess and continuous usage of pyrethroids cause resistance in h. armigera. therefore, expressions of midgut proteins of two h. armigera field populations were compared to those of a susceptible strain by 2-d page and maldi-tof-ms. our results indicate that h. armigera reacts to pyrethroid-induced stress mainly b ... | 2013 | 23685472 |
| a novel rat model of type 2 diabetes: the zucker fatty diabetes mellitus zfdm rat. | the zucker fatty (zf) rat harboring a missense mutation (fatty, fa) in the leptin receptor gene (lepr) develops obesity without diabetes; zucker diabetic fatty (zdf) rats derived from the zf strain exhibit obesity with diabetes and are widely used for research on type 2 diabetes (t2d). here we establish a novel diabetic strain derived from normoglycemic zf rats. in our zf rat colony, we incidentally found fa/fa homozygous male rats having reproductive ability, which is generally absent in these ... | 2013 | 23671847 |
| feasibility and repeatability for in vivo measurements of stiffness gradients in the canine gastrocnemius tendon using an acoustoelastic strain gauge. | b-mode ultrasound is an established imaging modality for evaluating canine tendon injury. however, full extent of tendon injury often remains difficult to estimate, as small changes in sonographic appearance are associated with large changes in biomechanical strength. the acoustoelastic strain gauge (asg) is an ultrasound-based tissue evaluation technique that relates the change in echo intensity observed during relaxation or stretching of tendons to the tissue's mechanical properties. this tech ... | 2017 | 23663072 |
| [viable myocardium evaluation by two dimensional speckle tracking imaging combined with adenosine stress echocardiography]. | regional left ventricular (lv) function could be detected by measuring peak-systolic strain by speckle tracking imaging (sti). we evaluated the value of sti combined with adenosine stress echocardiography on assessing myocardial viability in patients with myocardial infarction (mi). | 2013 | 23651964 |
| high efficiency degradation crude oil by a novel mutant irradiated from dietzia strain by 12c6+ heavy ion using response surface methodology. | crude oil is an extremely complex mixture of hydrocarbons; also contaminate environmental, leading to carcinogenic, teratogenic and mutagenic. petroleum hydrocarbons degradation dietzia strain dmyr9 was isolated from oilfield. response surface methodology was applied for statistical designing of process parameters for dry weight of biomass production in the process of degradation. the optimization process parameters were successfully employed for degradation crude oil and confirmed through confi ... | 2013 | 23603188 |
| left atrial longitudinal strain parameters predict postoperative persistent atrial fibrillation following mitral valve surgery: a speckle tracking echocardiography study. | postoperative atrial fibrillation (poaf) is common after cardiac surgery and is associated with increased morbidity, mortality, and prolonged hospital stay. speckle tracking echocardiography (ste) has been applied recently for evaluation of la function. the purpose of this study was to examine whether left atrial longitudinal strain measured by ste is a predictor for the development of poaf following mitral valve surgery for severe mitral regurgitation. we studied 53 patients undergoing mitral v ... | 2013 | 23600893 |
| layer-specific quantification of myocardial deformation by strain echocardiography may reveal significant cad in patients with non-st-segment elevation acute coronary syndrome. | our objective was to assess whether patients with significant coronary artery disease (cad) had reduced endocardial function assessed by layer-specific strain compared with patients without significant cad. | 2013 | 23582354 |
| construction of an endogenous selectable marker gene for the rice straw degrading white-rot basidiomycete cyathus stercoreus. | cyathus stercoreus has a superior ability to increase the cellulase saccharification yields of rice straw under biological pretreatment. as a first step to improve the biological pretreatment efficiency of c. stercoreus further, a new gene transformation system was constructed. uracil auxotrophic mutant uv-180 was generated as host strain by ultraviolet radiation. it was transformed using plasmid pge containing the orotate phosphoribosyltransferase (csura5) and enhanced green fluorescent protein ... | 2013 | 23563547 |
| identification of a loss-of-function mutation in ube2l6 associated with obesity resistance. | we previously mapped a locus on balb/c chromosome 2 associated with protection from leptin-deficiency-induced obesity. here, we generated the corresponding congenic mouse strain by introgression of a segment of c57bl/6j chromosome 2 to the balb/c background to confirm the genotype-phenotype associations. we found that the balb/c alleles decreased fat mass expansion by limiting adipocyte hyperplasia and adipocyte hypertrophy. this was concomitant to an increase in adipocyte triglyceride lipase (a ... | 2013 | 23557705 |
| anisotropic alteration of scleral birefringence to uniaxial mechanical strain. | to investigate the relationship between scleral mechanical properties, its birefringence, and the anisotropy of birefringence alteration in respect of the direction of the strain by using ps-oct. | 2013 | 23536816 |
| ultrasound elastography: principles, techniques, and clinical applications. | ultrasound elastography is an emerging set of imaging modalities used to image tissue elasticity and are often referred to as virtual palpation. these techniques have proven effective in detecting and assessing many different pathologies, because tissue mechanical changes often correlate with tissue pathological changes. this article reviews the principles of ultrasound elastography, many of the ultrasound-based techniques, and popular clinical applications. originally, elastography was a techni ... | 2013 | 23510006 |
| echocardiography-guided left ventricular lead placement for cardiac resynchronization therapy: results of the speckle tracking assisted resynchronization therapy for electrode region trial. | cardiac resynchronization therapy improves mortality and morbidity in patients with heart failure (hf) with wide qrs complex and diminished left ventricular (lv) function, but response is variable. | 2013 | 23476053 |
| volumetric evaluation of dual-energy perfusion ct by the presence of intrapulmonary clots using a 64-slice dual-source ct. | dual-energy perfusion ct (depct) directly represents the iodine distribution in lung parenchyma and low perfusion areas caused by intrapulmonary clots (ipcs) are visualized as low attenuation areas. | 2013 | 23474766 |
| [work strain by anaesthetic gas and surgical smoke due to tissue coagulation as well as safety measures in surgical operating rooms - what the surgeon needs to know]. | exposure of the respiratory tract during surgical interventions is an important topic of occupational medicine, which has only rarely been investigated. based on a literature search, relevant information on the possible health risk is summarised. within the operating room, an exposure of the respiratory tract to gas (volatile anaesthetics) and aerosols (smoking gas by coagulation) can occur. this exposure needs to be considered as a potential health risk if safety measures are not sufficient. he ... | 2013 | 23450398 |
| global structural motions from the strain of a single hydrogen bond. | the origin and biological role of dynamic motions of folded enzymes is not yet fully understood. in this study, we examine the molecular determinants for the dynamic motions within the β-barrel of superoxide dismutase 1 (sod1), which previously were implicated in allosteric regulation of protein maturation and also pathological misfolding in the neurodegenerative disease amyotrophic lateral sclerosis. relaxation-dispersion nmr, hydrogen/deuterium exchange, and crystallographic data show that the ... | 2013 | 23431167 |
| increased amount of interstitial fibrosis predicts ventricular arrhythmias, and is associated with reduced myocardial septal function in patients with obstructive hypertrophic cardiomyopathy. | reduced echocardiographic strain is associated with ventricular arrhythmias in hypertrophic cardiomyopathy (hcm) patients. the aim of this cross-sectional study was to investigate which type of histological fibrosis contributes to ventricular arrhythmias and reduced septal longitudinal strain, in obstructive hcm-patients with or without additional coronary artery disease (cad) and/or hypertension (ht). | 2013 | 23426552 |
| time-dependent ultrasound echo changes occur in tendon during viscoelastic testing. | the viscoelastic behavior of tendons has been extensively studied in vitro. a noninvasive method by which to acquire mechanical data would be highly beneficial, as it could lead to the collection of viscoelastic data in vivo. our lab has previously presented acoustoelasticity as an alternative ultrasound-based method of measuring tendon stress and strain by reporting a relationship between ultrasonic echo intensity (b mode ultrasound image brightness) and mechanical behavior of tendon under pseu ... | 2012 | 23387788 |
| on the influence of patient-specific material properties in computational simulations: a case study of a large ruptured abdominal aortic aneurysm. | patient-specific modelling of abdominal aortic aneurysm has been shown to have clinical potential. this paper examines a large ruptured abdominal aortic aneurysm where the tissue from the diseased wall and the intraluminal thrombus was excised during open surgical repair and experimentally characterised. the mechanical data were used to develop material parameters that were incorporated into finite element models with measured nonuniform wall thickness. implementation of the material data into t ... | 2013 | 23345202 |
| global and regional left ventricular myocardial deformation measures by magnetic resonance feature tracking in healthy volunteers: comparison with tagging and relevance of gender. | feature tracking software offers measurements of myocardial strain, velocities and displacement from cine cardiovascular magnetic resonance (cmr) images. we used it to record deformation parameters in healthy adults and compared values to those obtained by tagging. | 2013 | 23331550 |
| probing incipient plasticity by indenting colloidal glasses. | glasses are lucrative engineering materials owing to their superior mechanical properties such as high strength and large elastic strain. a central question concerns incipient plasticity - the onset of permanent deformation - that is central to their relaxation, aging, yield and fracture. here, we use an analogue of nano-indentation performed on a colloidal glass to obtain direct images of the incipient plasticity, allowing us to elucidate the onset of permanent deformation. we visualize the mic ... | 2013 | 23323208 |
| depressed atrial function in diastolic dysfunction: a speckle tracking imaging study. | two-dimensional speckle tracking imaging (sti) has recently been applied to the study of left atrial (la) reservoir function. we utilized sti to analyze la function in diastolic dysfunction (dd), hypothesizing that la strain abnormality is part of the pathogenesis of diastolic dysfunction. | 2013 | 23237327 |
| elastic image registration versus speckle tracking for 2-d myocardial motion estimation: a direct comparison in vivo. | despite the availability of multiple solutions for assessing myocardial strain by ultrasound, little is currently known about the relative performance of the different methods. in this study, we sought to contrast two strain estimation techniques directly (speckle tracking and elastic registration) in an in vivo setting by comparing both to a gold standard reference measurement. in five open-chest sheep instrumented with ultrasonic microcrystals, 2-d images were acquired with a ge vivid7 ultraso ... | 2013 | 23204281 |
| evaluation of factors affecting tibial bone strain after unicompartmental knee replacement. | persistent pain is an important cause of patient dissatisfaction after unicompartmental knee replacement (ukr) and has been correlated with localized tibial strain. however, the factors that influence these strains are not well understood. to address this issue, we created finite element models to examine the effect on tibial strain of: (1) muscle forces (estimated using instrumented knee data) acting on attachment sites on the proximal tibia, (2) ukr implantation, (3) loading position, and (4) ... | 2013 | 23192787 |
| biomechanical comparison of a single short and wide implant with monocortical or bicortical engagement in the atrophic posterior maxilla and a long implant in the augmented sinus. | the present study investigated the biomechanical interactions of a monocortically or bicortically engaged short and wide implant in the atrophic posterior maxilla and compared them to those of a long implant in the augmented sinus under different loading conditions via a nonlinear finite element (fe) approach. | 2012 | 23189315 |
| kinetics of chemical ordering in a ag-pt nanoalloy particle via first-principles simulations. | the energetics and kinetic energy barriers of vacancy/atom exchange in a 37-atom truncated octahedron ag-pt binary cluster in the ag-rich range of compositions are investigated via a first-principles atomistic approach. the energy of the local minima obtained considering various distributions of a single vacancy and a few pt atoms within the cluster and the energy barriers connecting them are evaluated using accurate density-functional calculations. the effects of the simultaneous presence of a ... | 2012 | 23181301 |
| salvage assessment with cardiac mri following acute myocardial infarction underestimates potential for recovery of systolic strain. | our aim was to evaluate the relationship between the degree of salvage following acute st elevation myocardial infarction (stemi) and subsequent reversible contractile dysfunction using cardiac magnetic resonance (cmr) imaging. | 2013 | 23179525 |
| layer-specific analysis of myocardial deformation for assessment of infarct transmurality: comparison of strain-encoded cardiovascular magnetic resonance with 2d speckle tracking echocardiography. | separate analysis of endocardial and epicardial myocardial layer deformation has become possible using strain-encoded cardiovascular magnetic resonance (senc) and 2d-dimensional speckle tracking echocardiography (echo). this study evaluated and compared both modalities for the assessment of infarct transmurality as defined by late gadolinium enhancement (lge) cardiovascular magnetic resonance (cmr). | 2013 | 23148082 |