| tolerated mouth-to-mouth food transfers in common marmosets. | in this paper we describe tolerated mouth-to-mouth food transfers in captive adult common marmosets, where an animal approached a conspecific that has recently received a piece of food, opened the other's mouth forcefully, and picked food pieces out of it. tolerated mouth-to-mouth food transfers occurred between animals of both sexes. they were observed when the possessor was subordinate as well as when it was dominant, and in four dyads they were observed in both directions. we argue that this ... | 2008 | 17940727 |
| the administration of entacapone prevents l-dopa-induced dyskinesia when added to dopamine agonist therapy in mptp-treated primates. | more continuous delivery of l-3,4-dihydroxyphenylalanine (l-dopa) achieved by combination with the catechol-o-methyl transfer (comt) inhibitor entacapone reduces the onset of dyskinesia in mptp-treated common marmosets compared with pulsatile l-dopa regimens. we now investigate whether l-dopa delivery also influences dyskinesia induction when added to dopamine agonist treatment. drug-naive 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride (mptp)-treated common marmosets were treated wit ... | 2007 | 17935716 |
| neurobehavioral protection by single dose l-deprenyl against mptp-induced parkinsonism in common marmosets. | establishment of preclinical method evaluating behavioral protective actions of drugs for parkinson's disease was attempted using l-deprenyl (dep) as a reference drug in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (mptp)-treated common marmosets. | 2008 | 17879087 |
| antiparkinsonian activity of l-propyl-l-leucyl-glycinamide or melanocyte-inhibiting factor in mptp-treated common marmosets. | the neuropeptide melanocyte-inhibiting factor (mif) or l-propyl-l-leucyl-glycinamide (plg) has been reported in some studies to improve the motor signs of parkinson's disease (pd) and in rodent models of pd. in this study of oral and intravenous mif in n-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-lesioned marmosets, a wide range of doses of mif administered alone (0.25, 1, 2, 5, 10, 20 mg/kg orally) did not increase locomotor activity, relieve motor disability, or induce dyskinesias. when ... | 2007 | 17373723 |
| plasma levels of rotigotine and the reversal of motor deficits in mptp-treated primates. | rotigotine is a nonergolinic dopamine d3/d2/d1-receptor agonist used clinically for the treatment of parkinson's disease. this study aimed to determine the relationship between peak antiparkinsonian activity and drug plasma levels after administration of rotigotine to 1-methyl-4-phenyl-1,2,3,6-tetrahydropytidine-treated primates. using single subcutaneous injections of rotigotine and blood sampling at two subsequent time points, the relationship between improvement in motor activity and plasma r ... | 2007 | 17351422 |
| decreased expression of l-dopa-induced dyskinesia by switching to ropinirole in mptp-treated common marmosets. | current concepts suggest that pulsatile stimulation of dopamine receptors following l-dopa administration leads to priming for dyskinesia in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride (mptp)-treated primates, while continuous dopaminergic stimulation with long-acting dopamine agonists does not. we investigated whether l-dopa-induced dyskinesia is reduced by switching to a dopamine agonist. mptp-treated marmosets received chronic treatment with l-dopa or ropinirole in doses produc ... | 2007 | 17113078 |
| in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated primates, the selective 5-hydroxytryptamine 1a agonist (r)-(+)-8-ohdpat inhibits levodopa-induced dyskinesia but only with\ increased motor disability. | 5-hydroxytryptamine 1a (5-ht(1a)) receptor agonists, such as sarizotan and tandospirone, are reported to reduce levodopa-induced dyskinesia in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-treated macaques and in parkinson's disease without worsening motor disability. however, these compounds are not specific for 5-ht(1a) receptors and also possess dopamine antagonist actions. we now report on the effects of (2r)-(+)-8-hydroxy-2-(di-n-propylamino)tetralin [(r)-(+)-8-ohdpat], a selective 5- ... | 2006 | 16959959 |
| the novel adenosine a2a receptor antagonist st1535 potentiates the effects of a threshold dose of l-dopa in mptp treated common marmosets. | adenosine a(2a) receptor antagonists may represent a novel non-dopaminergic approach to the treatment of parkinson's disease. however, there is little information available on their ability to reverse motor deficits in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine hydrochloride (mptp)-treated primates. we have studied the effects of the novel a(2a) receptor antagonist 2-butyl-9-methyl-8-(2h-1,2,3-triazol 2-yl)-9 h-purin-6-ylamine (st1535) alone and in combination with l-3, 4-dihydroxyphenylala ... | 2006 | 16925991 |
| switching from levodopa to the long-acting dopamine d2/d3 agonist piribedil reduces the expression of dyskinesia while maintaining effective motor activity in mptp-treated primates. | the control of motor complications following dopaminergic medication in late-stage parkinson disease remains problematic. | 2013 | 16772809 |
| contested dominance modifies the anovulatory consequences of social subordination in female marmosets. | dominance status among female marmosets is reflected in agonistic behavior and ovarian function. socially dominant females receive submissive behavior from subordinates, while exhibiting normal ovulatory function. subordinate females, however, receive agonistic behavior from dominants, while exhibiting reduced or absent ovulatory function. such disparity in female fertility is not absolute, and groups with two breeding females have been described. the data reported here were obtained from 8 fema ... | 2006 | 16648903 |
| mptp treatment of common marmosets impairs proteasomal enzyme activity and decreases expression of structural and regulatory elements of the 26s proteasome. | dysfunction of the ubiquitin-proteasome system occurs in the substantia nigra (sn) in parkinson's disease (pd). however, it is unknown whether this is a primary cause or a secondary consequence of other components of the pathogenic process. we have investigated in nonhuman primates whether initiating cell death through mitochondrial complex i inhibition using 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride (mptp) altered proteasomal activity or the proteasomal components in the sn. ch ... | 2006 | 16623833 |
| unilateral pallidotomy in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated common marmosets exhibiting levodopa-induced dyskinesia. | pallidotomy paradoxically reduces the intensity of levodopa-induced dyskinesia without worsening motor symptoms. the reasons for this are not clear and no experimental study has investigated this phenomenon. the objective of this investigation was to evaluate the effects of unilateral pallidotomy on locomotor activity, motor disability and levodopa-induced dyskinesia in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated levodopa-primed common marmosets. animals were primed to exhibit dyskinesi ... | 2005 | 16190886 |
| adult-infant food transfer in common marmosets: an experimental study. | infant marmosets and tamarins obtain solid food items from adults during and after the time of weaning. in addition to providing nutrients, food transfers may provide infants with the opportunity to learn about diet. the aim of this study was to investigate patterns of begging and food transfer in captive groups of common marmosets during tests with 1) palatable novel food, 2) unpalatable novel food, and 3) familiar food. infants may gain an opportunity to learn about diet breadth by preferentia ... | 2005 | 15834892 |
| effect of 5-ht1b/d receptor agonist and antagonist administration on motor function in haloperidol and mptp-treated common marmosets. | an interaction between brain serotonergic and dopaminergic systems involving 5-ht(1b) receptors may contribute to motor complications arising from the drug treatment of neurological and psychiatric disorders. this study assessed the effects of treatment with a non-selective 5-ht(1b/d) receptor agonist and a selective 5-ht(1b) receptor antagonist on akinesia induced in marmosets by long-term treatment with haloperidol and on motor disability and l-3, 4-dihydroxyphenylalanine (l-dopa)-induced dysk ... | 2004 | 15582011 |
| multiple small doses of levodopa plus entacapone produce continuous dopaminergic stimulation and reduce dyskinesia induction in mptp-treated drug-naive primates. | long-acting dopamine agonist drugs induce a lower incidence of dyskinesia in mptp-treated primates and patients with parkinson's disease compared to pulsatile treatment with levodopa, supporting the concept of continuous dopaminergic stimulation as a means of dyskinesia avoidance. we examined the effects of l-dopa administered with or without the comt inhibitor entacapone on dyskinesia induction in previously untreated mptp-treated common marmosets. administration of l-dopa (12.5 mg/kg p.o.) plu ... | 2005 | 15490461 |
| [the pharmacological and rational theory for the drug development of parkinson's disease]. | the basal ganglia in the brain contains glutamate, dopamine, serotonin, noradrenaline, cck, adenosine, opioid, cannabinoid, etc. these agents contribute to keep motor control and modulation of the agent may be a cue to the treatment of movement disorders. d1 or d2 dopamine receptor agonists increase locomotor activity in mptp-treated common marmosets which showed decreased locomotor activity and decreased number of dopamine neurons in the substantia nigra. using this model of parkinsonism, nmda ... | 2004 | 15462380 |
| the monoamine reuptake inhibitor bts 74 398 fails to evoke established dyskinesia but does not synergise with levodopa in mptp-treated primates. | long-term treatment of parkinson's disease (pd) with levodopa (l-dopa) induces dyskinesia that, once established, is provoked by each dose of l-dopa or a dopamine (da) agonist. in contrast, monoamine reuptake inhibitors may reverse motor deficits in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-treated primates without provoking established involuntary movements. we now examine whether the potent monoamine reuptake blocker bts 74 398 induces established dyskinesia in mptp-treated common ma ... | 2004 | 14743355 |
| modafinil prevents the mptp-induced increase in gabaa receptor binding in the internal globus pallidus of mptp-treated common marmosets. | the psychostimulant drug modafinil induces a reversal of motor deficits in mptp treated primates and prevents mptp toxicity to substantia nigra but its mechanism of action is not clear. in common marmosets acutely treated with mptp in the presence or absence of modafinil, we have studied changes in gaba(a) receptor binding in the basal ganglia. mptp treatment had no effect on [(3)h]-flunitrazepam (fnz) binding density in the striatum or external globus pallidus (gpe) but increased [(3)h]-fnz bin ... | 2004 | 14698469 |
| pharmacokinetics of l-dopa in plasma and extracellular fluid of striatum in common marmosets. | l-3, 4-dihydroxyphenylalanine (l-dopa) has been widely used for the treatment of parkinson's disease (pd), but its pharmacokinetics in the striatum have hardly been investigated, especially in primates. in this study, we examined the concentration of l-dopa in plasma and in the extracellular fluid (ecf) of the striatum in common marmosets using microdialysis and high-performance liquid chromatography (hplc) with electrochemical detection. with a clinically therapeutic dosage of l-dopa/benserazid ... | 2003 | 14642830 |
| 3,4-methylenedioxymethamphetamine (ecstasy) inhibits dyskinesia expression and normalizes motor activity in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated primates. | ecstasy [3,4-methylenedioxymethamphetamine (mdma)] was shown to prolong the action of l-3,4-dihydroxyphenylalanine (l-dopa) while suppressing dyskinesia in a single patient with parkinson's disease (pd). the clinical basis of this effect of mdma is unknown but may relate to its actions on either dopaminergic or serotoninergic systems in brain. in normal, drug-naive common marmosets, mdma administration suppressed motor activity and exploratory behavior. in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyr ... | 2003 | 14534244 |
| effect of pulsatile administration of levodopa on dyskinesia induction in drug-naïve mptp-treated common marmosets: effect of dose, frequency of administration, and brain exposure. | levodopa (l-dopa) consistently primes basal ganglia for the appearance of dyskinesia in parkinsonian patients and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride (mptp) -treated primates. this finding may reflect its relatively short duration of effects resulting in pulsatile stimulation of postsynaptic dopamine receptors in the striatum. we have compared the relationship between l-dopa dose and frequency of administration on dyskinesia initiation in drug-naïve, mptp-treated common ma ... | 2003 | 12722161 |
| infanticide and cannibalism in wild common marmosets. | infanticide has been observed in many different species [1], including common marmosets [2-4], due to sexual selection, reproductive strategies or resource competition [3, 5, 6], which may ultimately lead to exploitation (cannibalism) [1, 7]. wild callithrichids have a very flexible mating system, including monogamy, polygynandry, polyandry and polygyny [4, 8, 9], with monteiro da cruz [10] finding all these patterns within the same population. this results from the high degree of deforestation ... | 2003 | 12606850 |
| in vivo imaging of brain dopaminergic neurotransmission system in small animals with high-resolution single photon emission computed tomography. | high-resolution single photon emission computed tomography (spect) provides a unique capability to image the biodistribution of radiolabeled molecules in small laboratory animals. thus, we applied the high-resolution spect to in vivo imaging of the brain dopaminergic neurotransmission system in common marmosets using two radiolabeled ligands, [123i]2beta-carbomethoxy-3beta-(4-iodophenyl)tropane (beta-cit) as a dopamine transporter (dat) ligand and [123i]iodobenzamide (ibzm) as a dopamine d2 rece ... | 2003 | 12558026 |
| methylmercury poisoning in common marmosets--mri findings and peripheral nerve lesions. | common marmosets were used as model animals for methylmercury (mehg) poisoning. six marmosets were given mehg of 5 ppm hg in drinking water. the animals were divided into 3 groups of 2 each. the first group was examined for acute symptomatic mehg poisoning. they were given mehg for 70 and 90 days, respectively, to manifest severe symptoms. the second group was sacrificed after 38 days of mehg exposure, when they had acute-subclinical mehg poisoning. the third group of animals was exposed for 21 ... | 2017 | 12512874 |
| alterations in striatal neuropeptide mrna produced by repeated administration of l-dopa, ropinirole or bromocriptine correlate with dyskinesia induction in mptp-treated common marmosets. | chronic administration of l-dopa to mptp-treated common marmosets induces marked dyskinesia while repeated administration of equivalent antiparkisonian doses of ropinirole and bromocriptine produces only mild involuntary movements. the occurrence of dyskinesia has been associated with an altered balance between the direct and indirect striatal output pathways. using in situ hybridisation histochemistry, we now compare the effects of these drug treatments on striatal preproenkephalin-a (ppe-a) an ... | 2002 | 12453478 |
| dopamine, but not norepinephrine or serotonin, reuptake inhibition reverses motor deficits in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated primates. | monoamine reuptake inhibitors that do not discriminate between the transporters for dopamine (da), norepinephrine (ne), or 5-hydroxytryptamine (5-ht, serotonin) can reverse locomotor deficits and motor disability in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-treated common marmosets. da reuptake inhibition is presumed to be primarily responsible, but the role played by inhibition of ne and 5-ht reuptake is unknown. we now evaluate the efficacy of a range of monoamine reuptake inhibitors ... | 2002 | 12438514 |
| repeated administration of piribedil induces less dyskinesia than l-dopa in mptp-treated common marmosets: a behavioural and biochemical investigation. | piribedil ([1-(3,4-methylenedioxybenzyl)-4-(2-pyrimidinyl)piperazine]; s 4200) is a dopamine agonist with equal affinity for d(2)/d(3) dopamine receptors effective in treating parkinson's disease as monotherapy or as an adjunct to levodopa (l-dopa). however, its ability to prime basal ganglia for the appearance of dyskinesia is unknown. we now report on the ability of repeated administration of piribedil to induce dyskinesia in drug naïve 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) -lesi ... | 2002 | 12360537 |
| dopamine reuptake inhibition and failure to evoke dyskinesia in mptp-treated primates. | nonspecific monoamine reuptake inhibitors reverse motor abnormalities in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-treated marmosets without evoking established dyskinesia. however, it is not known whether dopamine reuptake inhibition alone explains these actions or whether noradrenaline and/or serotonin reuptake blockade also contributes. l-dopa (12.5 mg/kg, p.o.) rapidly reversed the baseline locomotor deficits and motor disabilities, but evoked dyskinesia (especially limb chorea) in ... | 2002 | 12231385 |
| behavioural and immunohistochemical changes following supranigral administration of sonic hedgehog in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated common marmosets. | sonic hedgehog (shh) has trophic actions on dopaminergic cell cultures and protects them from mpp(+) toxicity but its in vivo actions have not been explored. we now investigate the effects of unilateral supranigral administration of shh on nigro-striatal function in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated common marmosets. shh (0.1 or 1.0 microg) or vehicle was stereotaxically injected into the region of the right substantia nigra twice with an interval of 5 weeks between administra ... | 2002 | 12207958 |
| effects of pravastatin sodium on mevalonate metabolism in common marmosets. | in experimental animals and humans, the concentration of serum mevalonate (mva), a direct product of 3-hydroxy-3-methylglutaryl coenzyme a (hmg-coa) reductase, is considered to reflect the activity of whole-body sterol synthesis. the relationship between the concentration of serum mva and the activity of sterol synthesis in tissues, however, has not been fully clarified. in the present study, we examined mva metabolism by using pravastatin, a liver-selective inhibitor of hmg-coa reductase, and c ... | 2002 | 12204108 |
| the actions of a d-1 agonist in mptp treated primates show dependence on both d-1 and d-2 receptor function and tolerance on repeated administration. | the potent and long acting d-1 receptor agonist, a-77636 reverses motor deficits in mptp treated common marmosets following subcutaneous or oral administration. we now explore the effects of acute versus repeated administration of a-77636 and the relative roles of d-1 and d-2 receptor involvement in its antiparkinsonian actions. acute oral administration (0.18-9.0 mg/kg) or subcutaneous administration (0.036-1.08 mg/kg) of a-77636 produced well co-ordinated bouts of discontinuous locomotor activ ... | 2002 | 12075853 |
| testing for social learning in the "artificial fruit" processing of wildborn orangutans (pongo pygmaeus), tanjung puting, indonesia. | social learning about actions, objects and sequencing was investigated in a group of 14 wildborn orangutans (four adult females and ten 3- to 5-year-old juveniles). human models showed alternative methods and sequences for dismantling an artificial fruit to groups of participants matched by gender and age. each participant received three to six 2-min trials in which they were given access to the artificial fruit for manipulation. independent coders, who were unaware of which method each particip ... | 2001 | 24777521 |
| clozapine enhances breakpoint in common marmosets responding on a progressive ratio schedule. | motivational effects of psychotropic drugs may contribute to their therapeutic profile and progressive ratio (pr) schedules provide a method of measuring these effects in animals. | 2001 | 11401001 |
| gdnf reverses priming for dyskinesia in mptp-treated, l-dopa-primed common marmosets. | parkinson's disease (pd) is associated with a progressive loss of dopamine neurons in the substantia nigra and degeneration of dopaminergic terminals in the striatum. although l-dopa treatment provides the most effective symptomatic relief for pd it does not prevent the progression of the disease, and its long-term use is associated with the onset of dyskinesia. in rodent and primate studies, glial cell line-derived neurotrophic factor (gdnf) may prevent 6-ohda- or mptp-induced nigral degenerati ... | 2001 | 11168568 |
| effects of ropinirole on motor behavior in mptp-treated common marmosets. | the effects of ropinirole (4-[2-(dipropylamino)ethyl]-2-indolinone monohydrochloride), a nonergoline dopamine receptor agonist with a high affinity for native dopamine d(2)-like receptors, on parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp), 2.5 mg/animal in common marmosets were examined and compared to the effects of bromocriptine. ropinirole (0.1-3 mg/kg, po) increased motor activity dose dependently and reversed akinesia or uncoordinated movement in mptp-treated ma ... | 2000 | 11113491 |
| [functions and metabolic rates of transmitters in the basal ganglia]. | the caudate nucleus and putamen showed different neuronal circuits with the cerebral cortex and different functions in motor control. the dopamine content was same in the caudate nucleus and putamen, however, the turnover ratio was higher in the putamen than in the caudate nucleus, when it was studied in the control or mptp-treated marmosets. the dopaminergic neurons projecting to the putamen seemed to show higher activity than those projecting to the caudate nucleus. the caudate nucleus is long ... | 2000 | 11068436 |
| endogenous dopaminergic tone and dopamine agonist action. | dopamine receptor agonists provide symptomatic relief in the early stages of parkinson's disease, but with disease progression, their efficacy decreases. the reason behind this decrease in effectiveness is unknown, but maximal efficacy may be dependent on endogenous dopaminergic tone to provide stimulation of d1 and d2 receptor subtypes. therefore, we have investigated the effects of the tyrosine hydroxylase inhibitor alpha-methyl-p-tyrosine (ampt) on the actions of d1, d2, and d1/d2 agonists an ... | 2000 | 11009183 |
| naturally occurring and experimentally induced β-amyloid deposits in the brains of marmosets (callithrix jacchus). | cerebral β-amyloid occurs in elderly animals of some species and in alzheimer's disease. previously, we injected 3 young marmosets intracerebrally with brain tissue from a patient with alzheimer's disease. six years later, when the monkeys were middle aged, we found moderate numbers of intracerebral plaques and cerebrovascular deposits containing β-amyloid. we have re-examined these brains and those of 10 other marmosets injected with brain homogenate containing β-amyloid, and have found some β- ... | 2000 | 28567518 |
| the effects of central aromatic amino acid dopa decarboxylase inhibition on the motor actions of l-dopa and dopamine agonists in mptp-treated primates. | 1. endogenous l-dopa may act as a neuromodulator contributing to the production of motor activity. we now investigate the effects of the centrally acting aromatic amino acid dopa decarboxylase (aadc) inhibitor nsd-1015 (3-hydroxybenzyl hydrazine) on the motor actions of l-dopa and dopamine agonist drugs in mptp treated common marmosets. 2. pretreatment with nsd-1015 (10 - 50 mg kg(-1); i.p.) worsened baseline motor deficits in mptp-treated common marmosets. similarly, it abolished l-dopa (5 - 18 ... | 2000 | 10742291 |
| effects of beta-blockers and nicardipine on oxotremorine-induced tremor in common marmosets. | effects of beta-blockers (propranolol, arotinolol and nipradilol) and a ca2+ channel blocker (nicardipine) on oxotremorine-induced tremor were studied in common marmosets. generalized tremor was elicited by an intraperitoneal administration of 0.25 mg/kg oxotremorine. intensity of the tremor was classified into 7 degrees, and it was evaluated every 10 min. the total intensity of oxotremorine-induced tremor for each drug was expressed as "points", which were the sum of tremor intensity scores eva ... | 1999 | 10591485 |
| major histocompatibility complex class ii polymorphisms in primates. | in the past decade, the major histocompatibility complex (mhc) class ii region of several primate species has been investigated extensively. here we will discuss the similarities and differences found in the mhc class ii repertoires of primate species including humans, chimpanzees, rhesus macaques, cotton-top tamarins and common marmosets. such types of comparisons shed light on the evolutionary stability of mhc class ii alleles, lineages and loci as well as on the evolutionary origin and biolog ... | 1999 | 10319272 |
| actions of the d1 agonists a-77636 and a-86929 on locomotion and dyskinesia in mptp-treated l-dopa-primed common marmosets. | common marmosets show parkinsonian motor deficits following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) administration and develop dyskinesias during chronic l-dopa exposure. the d1 agonists a-77636 [(1r, 3s) 3-(1'-adamantyl)-1-aminomethyl-3, 4-dihydro-5, 6-dihydroxy-1h-2-benzopyran hcl] and a-86929 [(-)-trans 9, 10-hydroxy-2-propyl-4, 5, 5a, 6, 7, 11b-hexahydro-3-thia-5-azacyclopent-1-ena[c]phenanthrene hydrochloride] possess potent antiparkinsonian activity in the mptp-treated marmoset ... | 1999 | 10102782 |
| adenosine a2a receptors modify motor function in mptp-treated common marmosets. | both adenosine a1 and a2 receptor populations are located in the striatum and can modify locomotor activity, and they may form a therapeutic target for parkinson's disease (pd). administration of the selective adenosine a2a antagonist (e)-1,3-diethyl-8-(3,4-dimethoxystyryl)-7-methyl-3,7-dihydro-1h-pu rine-2,6-dione (kw-6002) to mptp-treated common marmosets increased locomotor activity. in contrast, administration of the selective a1 receptor antagonist 1,3-dipropyl-8-cyclopentylxantine (dpcpx) ... | 1998 | 9760134 |
| subchronic toxicity of di(2-ethylhexyl)phthalate in common marmosets: lack of hepatic peroxisome proliferation, testicular atrophy, or pancreatic acinar cell hyperplasia. | to evaluate the toxicological effect, di(2-ethylhexyl)phthalate (dehp) was administered orally at 100, 500, and 2500 mg/kg to four male and four female marmosets in each group for 13 weeks. its potentials of hepatic peroxisome proliferation, testicular atrophy, and pancreatic acinar cell hyperplasia were evaluated more closely. clofibrate, which potently causes peroxisome proliferation in rodents, was administered in like manner at 250 mg/kg as a reference drug. dehp induced significant suppress ... | 1998 | 9538047 |
| de novo administration of ropinirole and bromocriptine induces less dyskinesia than l-dopa in the mptp-treated marmoset. | in contrast to levodopa (l-dopa), de novo administration of the d2-like receptor agonist bromocriptine to patients with parkinson's disease (pd) or to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-treated subhuman primates is not associated with the onset of significant dyskinesia. we now compare the ability of the novel d2-like selective dopamine agonist ropinirole with that of bromocriptine and l-dopa to induce dyskinesia in mptp-treated common marmosets. mptp-treated common marmosets we ... | 1998 | 9539335 |
| effects of acute or prolonged administration of cabergoline on parkinsonism induced by mptp in common marmosets. | the effects of a single treatment or chronic administration of cabergoline (1-[(6-allylergolin-8beta-yl)carbonyl]-1-[3-(dimethylamino)p ropyl]-3-ethyl-urea), a potent, long-lasting dopamine receptor agonist, on parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) in common marmosets were studied. the administration of 0.2 mg/kg or a higer dose of cabergoline began to reverse parkinsonism-like symptoms 60 min after a subcutaneous injection, and showed steady and constant ef ... | 1998 | 9512077 |
| entacapone enhances levodopa-induced reversal of motor disability in mptp-treated common marmosets. | oral administration of levodopa (l-dopa) (2.5-25.0 mg/kg) plus carbidopa (12.5 mg/kg p.o.) to mptp-treated common marmosets produced a dose-related increase in locomotor activity and a corresponding decrease in motor disability. pretreatment with the peripheral comt inhibitor entacapone (12.5 mg/kg p.o.) enhanced the intensity and duration of the increase in locomotor activity and the reversal of motor disability produced by a threshold dose of l-dopa (2.5 mg/kg p.o.) plus carbidopa. by contrast ... | 1997 | 9399218 |
| escape from social suppression of sexual behavior and of ovulation in female common marmosets. | | 1997 | 9071400 |
| behavioral and social correlates of escape from suppression of ovulation in female common marmosets housed with the natal family. | although female common marmosets typically do not breed while housed with their natal families, up to half ovulate at least once while housed with the intact natal family, and a similar proportion conceive if an unrelated adult male is present in the group. in this study, we investigated the behavioral and social correlates of escape from suppression of ovulation by daughters housed in intact natal families or in families in which the father had been replaced by an unrelated adult male. focal-an ... | 1997 | 9064194 |
| temporal and structural features of infant calls in relation to caregiving behaviour in common marmosets, callithrix j. jacchus. | the role of infants in the communal rearing system of marmosets and tamarins has received little attention although their demands may not be complied by inadequate helpers. as acoustic signalling plays an important role in their social communication, it is expected to be an effective way for infants to signal their demand for care. as a first approach, this study focussed on the use and quality of 'tsik' calls given by infants of common marmosets (callithrix j. jacchus) in the context of caregiv ... | 1996 | 24896080 |
| survey of cryptosporidium and giardia spp. in a captive population of common marmosets. | | 1996 | 8699808 |
| l-dopa reverses altered gene expression of substance p but not enkephalin in the caudate-putamen of common marmosets treated with mptp. | the mrna levels encoding neuropeptides were measured in the caudate nucleus, putamen and nucleus accumbens of common marmosets exposed to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine pyridine (mptp). motor deficits induced by mptp treatment were characterized by akinesia, postural abnormalities and rigidity. seven days after mptp treatment, there was a marked increase in levels of enkephalin mrna in the caudate nucleus and putamen. in contrast, the hybridization signal for substance p mrna was r ... | 1995 | 7500841 |
| characteristics of the light-induced phase response of circadian activity rhythms in common marmosets, callithrix j. jacchus [primates-cebidae]. | phase-response experiments using 1-h light pulses (lps) of 1,100 lux applied under constant dim light of 0.3 lux were conducted with common marmosets, callithrix j. jacchus, in order to obtain a complete phase-response curve established according to the common experimental procedure in a diurnal primate. maximal phase delays of the free-running circadian activity rhythm (-90 min) were induced by lps delivered at circadian time (ct) 12; e.g., during the beginning of the marmosets' rest time, maxi ... | 1994 | 7828210 |
| effects of talipexole on motor behavior in normal and mptp-treated common marmosets. | administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp, 0.5 mg/animal i.v. once or twice) to common marmosets induced persistent parkinsonian motor deficits. the postsynaptic dopamine d2 receptor agonist properties of talipexole (b-ht 920, 2-amino-6-allyl-5,6,7,8-tetrahydro-4h-thiazolo[4,5-d]-azepine), which is believed to be a dopamine autoreceptor agonist, were examined using normal and mptp-treated marmosets and were compared to these properties of bromocriptine, a selective dop ... | 1993 | 8104807 |
| age-related effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment of common marmosets. | the effect of treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) on juvenile (6-8 months), young adult (2-4 years) and aged (8-10 years) common marmosets were compared. juvenile marmosets were more resistant to the actions of mptp and required a greater cumulative dose over a longer period to induce the same degree of motor disability observed in older animals. young adult and aged marmosets showed an equivalent motor recovery in the 4-5 weeks following cessation of mptp treatmen ... | 1993 | 8422900 |
| terguride stimulates locomotor activity at 2 months but not 10 months after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment of common marmosets. | the mixed dopamine (da) agonist/antagonist terguride acts as a da antagonist on normosensitive receptors but shows da agonistic properties at supersensitive da receptors. such a compound could offer an alternative to the treatment of parkinson's disease with indirect or direct da agonists. the present study compares the actions of terguride, 4-12 mg/kg i.p., in naive common marmosets with its effects in animals rendered parkinsonian by administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridi ... | 1992 | 1350996 |
| motor activity following the administration of selective d-1 and d-2 dopaminergic drugs to mptp-treated common marmosets. | the ability of selective d-1 agonist and antagonist drugs to alter motor deficits and locomotor activity was studied in mptp-treated common marmosets. both the d-2 agonist quinpirole and the mixed d-1/d-2 agonist apomorphine reversed the motor impairments and induced locomotor activity. the d-1 antagonist sch 23390 and the d-2 antagonist raclopride given alone further reduced motor function in mptp-treated animals. the actions of quinpirole were potently and completely inhibited by raclopride bu ... | 1992 | 1365671 |
| extensive loss of brain dopamine and serotonin induced by chronic administration of mptp in the marmoset. | common marmosets were given a subcutaneous injection of mptp (1.25-2.5 mg/kg twice a week) for 5 or 10 consecutive months and were sacrificed after a survival time of 6 months or 15 days, respectively. the parkinsonian symptoms were not very marked at the time of sacrifice but there was a strong decrease of dopamine and, to a lesser extent, of its metabolites in the striatum and in some extrastriatal regions. there was also a profound loss of serotonin in the striatum and in all of the extrastri ... | 1991 | 1815820 |
| neuropeptide levels in the basal ganglia of aged common marmosets following prolonged treatment with mptp. | aged common marmosets were treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp; 0.5-2.0 mg/kg/week i.p.) for 16 or 24 weeks, observed for a total of 30 weeks and then killed for measurement of biochemical parameters in basal ganglia. the mptp treatment induced a marked depletion in dopamine, 3,4-dihydroxyphenylacetic acid and homovanillic acid levels in the caudate nucleus and putamen. in contrast, the concentrations of five neuropeptides: [met5]-enkephalin, [leu5]-enkephalin, cholec ... | 1991 | 1716907 |
| splitting of the circadian activity rhythm in common marmosets (callithrix j. jacchus; primates). | long-term recordings of the free-running circadian activity rhythm in common marmosets, callithrix j. jacchus, living under constant environmental conditions (ll 200-470 lx) provided evidence of rhythm splitting in nonhuman primates. in two out of ten test animals two different types of splitting occurred; spontaneous persistent splitting and temporary splitting. neither a reduction of the illumination intensity nor the application of dark pulses had any effect on the two activity components of ... | 1989 | 2513221 |
| learning about rules but not about reward is impaired following lesions of the cholinergic projection to the hippocampus. | common marmosets with bilateral ibotenic acid-induced destruction of the neurones of the vertical limb of the diagonal band of broca, which provide the major cholinergic input to the hippocampal formation, were impaired on the acquisition but not on the retention of a repeated-trial visuospatial discrimination learning task. they were also impaired on serial spatial reversal learning (but not on serial object reversal learning), on acquisition of a trial-independent successive concurrent discrim ... | 1989 | 2510907 |
| transient depletion of nucleus accumbens dopamine content may contribute to initial akinesia induced by mptp in common marmosets. | acute treatment of common marmosets with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) caused an initial profound akinesia and other motor deficits. however, over the following months akinesia gradually disappeared although the animals remained clumsy and poorly coordinated. at 10 days following mptp treatment there was a profound decrease in the dopamine, hva and dopac content of the caudate nucleus, putamen and nucleus accumbens. by 3-4 months following mptp treatment the animals had lar ... | 1989 | 2597167 |
| treatment with a selective mao b inhibitor prevents loss of dopamine in the nucleus accumbens of mptp-treated common marmosets. | administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) to common marmosets induced motor deficits, associated with a marked decrease in the uptake of [3h]dopamine into synaptosomes in the putamen and a reduction in the content of dopamine in both caudate nucleus and nucleus accumbens. histological analysis showed a marked loss of dopamine-containing cells in the zona compacta of the substantia nigra and less loss in the ventral tegmental area. treatment of animals with the selecti ... | 1989 | 2512516 |
| further treatment with mptp does not produce parkinsonism in marmosets showing behavioural recovery from motor deficits induced by an earlier exposure to the toxin. | 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp), or 0.9% saline, was administered to a group of common marmosets initially treated with the toxin 12-18 months previously. initial treatment had consisted of a cumulative dose of 6-22 mg/kg (i.p.) which caused marked parkinsonism. subsequently, the animals gradually recovered normal motor function. further treatment consisted of a cumulative dose of mptp of 78-83 mg/kg (i.p.) but this produced only modest akinesia. at 12-18 months after the ini ... | 1989 | 2510050 |
| increased caudate dopamine turnover may contribute to the recovery of motor function in marmosets treated with the dopaminergic neurotoxin mptp. | administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) to common marmosets initially impaired motor function, but a partial recovery occurred over the following weeks. at both 10 days and 4-6 weeks following mptp treatment, [3h]dopamine ([3h]da) uptake into synaptosomal preparations of putamen was markedly decreased. at 10 days and 4-6 weeks following mptp treatment da, homovanillic acid (hva) and 3,4-dihydroxyphenylacetic acid (dopac) levels in the caudate nucleus and nucleus acc ... | 1989 | 2505199 |
| the d1 agonist skf 38393 inhibits the antiparkinsonian activity of the d2 agonist ly 171555 in the mptp-treated marmoset. | administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) to common marmosets induced persistent motor deficits. administration of the d1 agonist skf 38393 (2.5-20 mg/kg, i.p.) caused a dose-dependent increase of this akinesia. administration of the d2 agonist ly 171555 (0.3 mg/kg, i.p.) reversed the motor deficits induced by mptp treatment. pretreatment of animals with skf 38393 (2.5-20 mg/kg, i.p.) caused dose-dependent inhibition of the anti-parkinsonian action of ly 171555 (0.3 m ... | 1988 | 2907373 |
| the d-1 dopamine receptor partial agonist, cy 208-243, exhibits antiparkinsonian activity in the mptp-treated marmoset. | administration of l-dopa plus carbidopa, or the d-2 agonist (+)-phno, to mptp-treated common marmosets caused motor hyperactivity and a reversal of the parkinsonian syndrome. in contrast, administration of the putative d-1 agonist skf 38393 was without effect on movement or motor disability. the subsequent administration of another putative selective d-1 partial agonist cy 208-243 produced a dose-related improvement in motor activity and reversal of parkinsonian motor deficits in mptp-treated an ... | 1988 | 2977118 |
| coprophagy in marmosets due to insufficient protein (amino acid) intake. | in the course of experiments to study the minimal protein requirement of common marmosets by nitrogen balance methods, coprophagy was observed. it occurred in most animals fed diets either with a protein content below 6% or lacking histidine/arginine. the protein level of 6% had previously been evaluated as being the minimal protein requirement for maintenance of marmosets. | 1988 | 3148060 |
| 4-phenylpyridine and three other analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine lack dopaminergic nigrostriatal neurotoxicity in mice and marmosets. | c57 black mice were injected repeatedly with maximal tolerated doses of 2 chemical analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp); 4-phenylpyridine and 4-phenyl-1,2,3,6-tetrahydropyridine. although both compounds were clearly acutely toxic to mice, neither caused any reduction in striatal dopamine content after chronic exposure. two mptp analogues which may be formed endogenously during the metabolism of brain monoamines, 2-methyl-1,2,3,4-tetrahydroisoquinoline and 2-methyl-1,2 ... | 1987 | 3106859 |
| comparative anatomical and neurohistological observations on the tongues of pigmy and common marmosets. | | 1964 | 14248318 |
| expression pattern of eya4 in the common marmoset (callithrix jacchus) cochlea. | the eyes absent (eya)-like genes are essential for the formation of sensory organs among fly (drosophila melanogaster) and mammals. eya4, one of the vertebrate genes of eya family, is reported to be causative for late-onset mid-frequency sensorineural hearing loss in humans, while eya4-deficient mice exhibited congenital profound deafness and otitis media with effusion due to the eustachian tube dysmorphology. because of the species difference in the phenotype, the pathophysiology of eya4 in the ... | 2018 | 29054432 |
| bifidobacterium catulorum sp. nov., a novel taxon from the faeces of the baby common marmoset (callithrix jacchus). | in our previous study based on hsp60 pcr-restriction fragment length polymorphism and 16s rrna gene sequencing, we stated that the bifidobacterial strains isolated from the individual faecal samples of five baby common marmosets constituted different phylogenetically isolated groups of the genus bifidobacterium. in that study, we also proposed that these isolated groups potentially represented novel species of the genus bifidobacterium. out of them, bifidobacterium aesculapii, bifidobacterium my ... | 2018 | 29300153 |
| a retrospective analysis of adverse effects of an in vivo fluoroquinolone antibiotic enrofloxacin treatment on oocyte quality in the common marmoset. | here we report a retrospective analysis of negative effects of routine enrofloxacin treatment of recurrent diarrhea on the ovary and the developing oocytes of the common marmoset, a small new world primate. the most deleterious effect on oocytes was observed about two months post treatment suggesting that the enrofloxacin effect is on early growing follicles. manifestations of toxicity included decreased numbers of growing follicles and recovered culturable oocytes, as well as signs of early atr ... | 2018 | 29247838 |
| marmoset cytochrome p450 2b6, a propofol hydroxylase expressed in liver. | 1. the common marmoset (callithrix jacchus) is a useful experimental animal to evaluate the pharmacokinetics of drug candidates. cytochrome p450 (p450) 2b enzyme in marmoset livers has been identified; however, only limited information on the enzymatic properties and distribution has been available. 2. marmoset p450 2b6 amino acids showed high sequence identities (>86%) with those of primates including humans and cynomolgus monkeys. phylogenetic analysis using amino acid sequences indicated that ... | 2018 | 29417863 |
| comparative immunity of antigen recognition, differentiation, and other functional molecules: similarities and differences among common marmosets, humans, and mice. | the common marmoset (cm; callithrix jacchus) is a small new world monkey with a high rate of pregnancy and is maintained in closed colonies as an experimental animal species. although cms are used for immunological research, such as studies of autoimmune disease and infectious disease, their immunological characteristics are less defined than those of other nonhuman primates. we and others have analyzed antigen recognition-related molecules, the development of hematopoietic stem cells (hscs), an ... | 2018 | 29415910 |
| inequity aversion is observed in common marmosets but not in marmoset models of autism induced by prenatal exposure to valproic acid. | humans and various nonhuman primates respond negatively to inequity not in their favor (i.e., inequity aversion), when inequity between two individuals is introduced. common marmosets, a highly prosocial species, further discriminated between human actors who reciprocated in social exchanges, and those who did not. conversely, marmoset models of autism, induced via prenatal exposure to valproic acid (vpa marmosets), did not discriminate. interestingly, previous studies of inequity aversion in ma ... | 2018 | 29374522 |
| the effect of banisteriopsis caapi (b. caapi) on the motor deficits in the mptp-treated common marmoset model of parkinson's disease. | banisteriopsis caapi (b. caapi) contains harmine, harmaline, and tetrahydroharmine, has monoamine oxidase inhibitory activity, and has reported antiparkinsonian activity in humans when imbibed as a tea; however, its effects are poorly documented. for this reason, motor function was assessed in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated common marmosets following administration of b. caapi extract (28.4-113.6 mg/kg; po), harmine (0.1 and 0.3 mg/kg; sc), and selegiline (10 mg/kg; sc), al ... | 2018 | 29368409 |
| methods for chair restraint and training of the common marmoset on oculomotor tasks. | the oculomotor system is the most thoroughly understood sensorimotor system in the brain, due in large part to electrophysiological studies carried out in macaque monkeys trained to perform ocuolomotor tasks. a disadvantage of the macaque model is that many cortical oculomotor areas of interest lie within sulci, making high-density array and laminar recordings impractical. many techniques of molecular biology developed in rodents, such as optogenetic manipulation of neuronal subtypes, are also l ... | 2018 | 29364068 |
| investigation of the bold and cbv fmri responses to somatosensory stimulation in awake marmosets (callithrix jacchus). | understanding the spatiotemporal features of the hemodynamic response function (hrf) to brain stimulation is essential for the correct application of neuroimaging methods to study brain function. here, we investigated the spatiotemporal evolution of the blood oxygen level-dependent (bold) and cerebral blood volume (cbv) hrf in conscious, awake marmosets (callithrix jacchus), a new world non-human primate with a lissencephalic brain and with growing use in biomedical research. the marmosets were ... | 2018 | 29285809 |
| genetic polymorphisms of drug-metabolizing cytochrome p450 enzymes in cynomolgus and rhesus monkeys and common marmosets in preclinical studies for humans. | cynomolgus monkeys (macaca fascicularis, old world monkeys) and common marmosets (callithrix jacchus, new world monkeys) have been widely, and expectedly, used as non-human primate models in drug development studies. major drug-metabolizing cytochrome p450 (p450) enzymes information is now available that supports these primate species as animal models, and it is established that multiple forms of cynomolgus monkey and common marmoset p450 enzymes have generally similar substrate recognition func ... | 2017 | 29277691 |
| bisphenol a-induced ultrastructural changes in the testes of common marmoset. | bisphenol a (bpa) is an endocrine disruptor that is widely used in the manufacture of polycarbonate plastics, epoxy resins and dental sealants. it is known to have adverse effects on spermatogenesis in rodents. this study was aimed to evaluate the effects of bpa in adult common marmoset owing to its similarities with human spermatogenesis. | 2017 | 29168469 |
| evolution of vomeronasal receptor 1 (v1r) genes in the common marmoset (callithrix jacchus). | pheromones are crucial for eliciting innate responses and inducing social and sexual behaviors in mammals. the vomeronasal receptor 1 genes, v1rs, encode members of a pheromone receptor family that are mainly expressed in the vomeronasal organ (vno). the v1r family shows extraordinary variety in gene number among vertebrates owing to successive gene gains and losses during evolution. such diversity is believed to reflect a degree of dependence on the vno. we investigated v1r evolution in primate ... | 2018 | 29155331 |
| molecular cloning and tissue distribution of a novel marmoset abc transporter. | common marmosets (callithrix jacchus) have been recognized as a useful small non-human primate model in preclinical testing for drug development. in this study, a cdna of novel atp-dependent efflux transporter abcb1 was cloned from marmoset liver tissue. marmoset abcb1 cdna encodes a protein of 1279 amino acid residues (mw = 141.4 kda) containing characteristic regions of an atp-binding cassette (abc) protein, two hydrophobic transmembrane regions and two cytoplasmic nucleotide-binding regions, ... | 2018 | 29059459 |
| common marmoset (callithrix jacchus) personality. | increasing evidence suggests that personality structure differs between species, but the evolutionary reasons for this variation are not fully understood. we built on earlier research on new world monkeys to further elucidate the evolution of personality structure in primates. we therefore examined personality in 100 family-reared adult common marmosets (callithrix jacchus) from 3 colonies on a 60-item questionnaire. principal components analyses revealed 5 domains that were largely similar to t ... | 2017 | 29022726 |
| common marmosets: a potential translational animal model of juvenile depression. | major depression is a psychiatric disorder with high prevalence in the general population, with increasing expression in adolescence, about 14% in young people. frequently, it presents as a chronic condition, showing no remission even after several pharmacological treatments and persisting in adult life. therefore, distinct protocols and animal models have been developed to increase the understanding of this disease or search for new therapies. to this end, this study investigated the effects of ... | 2017 | 28983260 |
| non-human primate and rodent embryonic stem cells are differentially sensitive to embryotoxic compounds. | many industrial chemicals and their respective by-products need to be comprehensively evaluated for toxicity using reliable and efficient assays. in terms of teratogenicity evaluations, the murine-based embryonic stem cell test (est) offers a promising solution to screen for multiple tissue endpoints. however, use of a mouse model in the est can yield only a limited understanding of human development, anatomy, and physiology. non-human primate or humanin vitromodels have been suggested to be a p ... | 2015 | 28962348 |
| genotype-specific and cross-reactive neutralizing antibodies induced by dengue virus infection: detection of antibodies with different levels of neutralizing activities against homologous and heterologous genotypes of dengue virus type 2 in common marmosets (callithrix jacchus). | a vaccine against all four dengue virus (denv) serotypes includes the formulation of one genotype of each serotype. although genetic similarities among genotypes within a serotype are higher as compared to those among serotypes, differences in the immunogenicity of the included genotypes would be a critical issue in maximizing successful dengue vaccine development. thus, we determined the neutralizing antibody responses against three genotypes of dengue virus serotype 2 (denv-2), namely cosmopol ... | 2018 | 29587780 |
| the development of a specific pathogen free (spf) barrier colony of marmosets (callithrix jacchus) for aging research. | a specific pathogen free (spf) barrier colony of breeding marmosets (callithrix jacchus) was established at the barshop institute for longevity and aging studies. rodent and other animal models maintained as spf barrier colonies have demonstrated improved health and lengthened lifespans enhancing the quality and repeatability of aging research. the marmosets were screened for two viruses and several bacterial pathogens prior to establishing the new spf colony. twelve founding animals successfull ... | 2017 | 29227963 |
| dynamics of pathological and virological findings during experimental calpox virus infection of common marmosets (callithrix jacchus). | experimental intranasal infection of marmosets (callithrix jacchus) with calpox virus results in fatal disease. route and dose used for viral inoculation of the test animals mimics the natural transmission of smallpox, thus representing a suitable model to study pathogenesis and to evaluate new vaccines against orthopoxvirus infection. however, the pathogenic mechanisms leading to death are still unclear. therefore, our study aimed at investigating the kinetics of pathological alterations to cla ... | 2017 | 29182537 |
| marmosets (callithrix jacchus) as a non-human primate model for evaluation of candidate dengue vaccines: induction and maintenance of specific protective immunity against challenges with clinical isolates. | dengue virus (denv) is one of the major infectious diseases in tropical regions and approximately half of the world population is at risk of infection. vaccines would offer an effective control measure against this disease. we previously reported on the utility of marmosets as an animal model for studying primary and secondary dengue infections. infected marmosets consistently develop viraemia and antibody kinetics that reflect those of patients with dengue. thus, it is important to determine th ... | 2017 | 29160199 |
| a chronically implantable bidirectional neural interface for non-human primates. | optogenetics has potential applications in the study of epilepsy and neuroprostheses, and for studies on neural circuit dynamics. however, to achieve translation to clinical usage, optogenetic interfaces that are capable of chronic stimulation and monitoring with minimal brain trauma are required. we aimed to develop a chronically implantable device for photostimulation of the brain of non-human primates. we used a micro-light-emitting diode (led) array with a flexible polyimide film. the array ... | 2017 | 28966573 |
| hepatic immunopathology during occult hepacivirus re-infection. | despite drug advances for hepatitis c virus (hcv), re-infections remain prevalent in high-risk populations. unfortunately, the role of preexisting viral immunity and how it modulates re-infection is unclear. gbv-b infection of common marmosets is a useful model to study tissue immune responses in hepacivirus infections, and in this study we re-challenged 4 animals after clearance of primary viremia. although only low-to-absent viremia was observed following re-challenge, gbv-b viral rna was dete ... | 2017 | 28915405 |
| high susceptibility, viral dynamics and persistence of south american zika virus in new world monkey species. | south american zika virus (zikv) recently emerged as a novel human pathogen, linked with neurological disorders. however, comparative zikv infectivity studies in new world primates are lacking. two members of the callitrichidae family, common marmosets (callithrix jacchus) and red-bellied tamarins (saguinus labiatus), were highly susceptible to sub-cutaneous challenge with the puerto rico-origin zikvprvabc59 strain. both exhibited rapid, high, acute viraemia with early neuroinvasion (3 days) in ... | 2019 | 31601848 |
| multimodal assessments of zika virus immune pathophysiological responses in marmosets. | animal models that recapitulate the human pathophysiology have been developed as useful research tools. although laboratory mice are widely used, they are phylogenetically "distant" to humans. new world monkeys, such as the common marmoset (callithrix jacchus) have steadily gained prominence. in this report, marmosets are explored as an alternate in vivo model to investigate infection and immunity of zika virus (zikv). multimodal platforms, including ultrasound and magnetic resonance imaging (mr ... | 2018 | 30459473 |
| publisher correction: experimental zika virus infection in the pregnant common marmoset induces spontaneous fetal loss and neurodevelopmental abnormalities. | a correction to this article has been published and is linked from the html and pdf versions of this paper. the error has been fixed in the paper. | 2018 | 30367092 |
| experimental zika virus infection in the pregnant common marmoset induces spontaneous fetal loss and neurodevelopmental abnormalities. | during its most recent outbreak across the americas, zika virus (zikv) was surprisingly shown to cause fetal loss and congenital malformations in acutely and chronically infected pregnant women. however, understanding the underlying pathogenesis of zikv congenital disease has been hampered by a lack of relevant in vivo experimental models. here we present a candidate new world monkey model of zikv infection in pregnant marmosets that faithfully recapitulates human disease. zikv inoculation at th ... | 2018 | 29717225 |
| urinary steroid and gonadotropin excretion across the reproductive cycle in female wied's black tufted-ear marmosets (callithrix kuhli). | details of the endocrinology of reproduction in the genus callithrix are known only for the common marmoset, c. jacchus. this paper presents the patterns of urinary pregnandiol-3-glucuronide (pdg), urinary estrone conjugates (e1c), and gonadotropin excretion throughout the reproductive cycle of wied's black tufted-ear marmoset (c. kuhli) as determined via steroid conjugate enzyme immunoassays (eia) and gonadotropin radioimmunoassays (ria). postpartum ovulation occurred at 13.6 ± 1.2 days after p ... | 1996 | 31918517 |
| small but wise: common marmosets (callithrix jacchus) use acoustic signals as cues to avoid interactions with blonde capuchin monkeys (sapajus flavius). | vocalizations are often used by animals to communicate and mediate social interactions. animals may benefit from eavesdropping on calls from other species to avoid predation and thus increase their chances of survival. here we use both observational and experimental evidence to investigate eavesdropping and how acoustic signals may mediate interactions between two sympatric and endemic primate species (common marmosets and blonde capuchin monkeys) in a fragment of atlantic rainforest in northeas ... | 2018 | 29488642 |
| dental signatures for exudativory in living primates, with comparisons to other gouging mammals. | exudativory, the consumption of gums, is an obligate or a facultative dietary niche for some primates and marsupials. exudativory has been cited as a dietary niche that may have been present in early primates, so finding a dental signature for exudativory is highly desirable. the present study combines exudativorous lorisoids (galagos and lorises) into one sample to compare to closely related, non-exudativorous lorisoids to search for a consistent dental signature of exudativory. linear measurem ... | 2020 | 30548805 |
| functional morphology of mimetic musculature in primates: how social variables and body size stack up to phylogeny. | mammalian skeletal muscle is influenced by the functional demands placed upon it. functional morphology of facial expression musculature, or mimetic musculature, is largely unknown. recently, primate mimetic musculature has been shown to respond to demands associated with social factors. body size has also been demonstrated to affect many aspects of primate functional morphology and evolutionary morphology. the present study was designed to further examine the role of social variables and body s ... | 2018 | 29330949 |