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effect of a high-fat meal on the bioavailability of a polymer-coated erythromycin particle tablet formulation.the effect of food on the relative bioavailability of an erythromycin particles-in-tablet formulation was studied in 27 healthy volunteers, using a four-way, crossover study design with the following treatments: one or two erythromycin capsules usp (eryc, parke-davis), or one polymer-coated erythromycin particles-in-tablet (pce, abbott) administered fasting or with a high-fat meal. under fasting conditions the erythromycin particles-in-tablet and erythromycin capsule formulations are bioequivale ...20092708552
risk factors for infantile recurrent otitis media: atopy but not type of feeding.we followed 183 infants from birth to 2.3 yr of age. of these infants 28 had recurrent otitis media (rom), defined as five or more separate episodes of otitis media (om) during the first 2 yr of life or four such episodes during their 2nd yr. the om presented during their 1st yr (early-onset rom) in 12 infants and during their 2nd yr (2nd yr rom) in 16. eighty infants had no om and served as a comparison group. regarding type of feeding, the infants with early-onset rom did not differ from their ...20123387173
antidesmosomal monoclonal antibody in the diagnosis of intracranial tumours.immunocytochemistry has been applied extensively to the diagnosis of intracranial tumours, but meningiomas still present a diagnostic problem. however, desmosomes have been shown by electron microscopy to be present in meningiomas, and this distinguishes them from gliomas. this paper describes a new monoclonal antibody, 11-5f, against desmosomal proteins 1 and 2 (desmoplakins) and assesses its usefulness in the diagnosis of meningiomas and other intracranial tumours. a total of 74 surgically rem ...20123323433
the role of androstenedione and testosterone in the reproduction and antler growth of a male white-tailed deer.seasonal levels of androstenedione and testosterone were investigated in plasma of mature intact and castrated male white-tailed deer. in four intact bucks, androstenedione concentrations were low in february and march (around 1 nmol/l) and then increased significantly (p less than 0.05) from april to november (peak 2.34 nmol/l). testosterone remained low (below 3.5 nmol/l) from february to august and then rose significantly (p less than 0.01) till november (peak 36.78 nmol/l). both hormones dec ...20133811770
[polycarboxylate cements]. 20144211561
steroid therapy in tonsillectomy. 20155014392
a study of stress and coronary heart disease in an urban population. 20154513127
a new species of the early tertiary rodent thisbemys. 20133716069
inhibition of antibody production in plasmacytoma cells. iii. interactions of suppressive and nonsuppressive dnp conjugates with mopc 315 cells. 200087442
[left ventricular wall thickness in hypertrophic cardiomyopathy: comparisons of measurements by magnetic resonance imaging, cineangiography, and echocardiography].to evaluate the usefulness of magnetic resonance imaging (mri) in measuring regional wall thickness of the left ventricle, 11 patients with hypertrophic cardiomyopathy (hcm) were imaged. the measurements were compared with those obtained by two-dimensional echocardiography (2d-echo) and cineangiography. regional wall thickness was ascertained at six locations including the base, middle, and apex of the interventricular septum (ivs) and left ventricular posterior wall (lvpw) from the two selected ...20123267712
controversy of the decade. coronary artery bypass graft (cabg) surgery. 2003308925
[a case of posttraumatic cerebral air embolism].we report a case of cerebral air embolism that occurred after chest trauma. the diagnosis was confirmed by ct and skull roentgenogram which demonstrated air bubbles in intracranial arteries. it is well recognized that cerebral air embolism is caused by various diagnostic and therapeutic procedures, and trauma. but it may often be overlooked because it is diagnosed clinically and there are no characteristic symptoms nor signs. although various ways of treatment have been reported, prevention and ...20082586716
[prostheses on osteointegrated implants: restoration of a missing tooth (4)].this article is the last of a series of four. this article describes in detail the fabrication of a crown connected to a brånemark implant.20082394869
reversal of rejection-induced coronary vasculitis detected early after heart transplantation with increased immunosuppression.four patients who underwent heart transplantation, in whom coronary obstruction was seen early after transplantation, are described. repeated acute rejection episodes were detected within the first 2 months in each patient. coronary obstruction or ischemia was shown through a combination of t1-201 isotopic study findings, evidence of vasculitis of a small coronary arteriole seen at endomyocardial biopsy, or coronary angiographic results. vigorous treatment for rejection (antithymocyte globulin a ...20092795284
activation of a cytosolic serine protein kinase by epidermal growth factor.exposure of a-431 cells to epidermal growth factor (egf) results in a rapid enhancement (approximately 10-fold) of cytosolic serine protein kinase activity. the increase in serine kinase activity may be detected using a number of peptide and protein substrates. enhancement of kinase activity occurs within 1 min of exposure of the cells to egf and reaches a maximum in 5 min. similar results were obtained with a variety of cell lines. we have partially purified the egf-activated kinase from a-431 ...20102974035
morbidity and mortality of carotid endarterectomy under local anesthesia: a retrospective study.it has been shown that carotid endarterectomy reduces the incidence of stroke in patients with symptomatic extracranial occlusive vascular disease in the absence of major perioperative complications such as stroke or death. we present a retrospective study of 106 carotid endarterectomies performed under local anesthesia in 100 patients in whom transient ischemic attack (tia) or minor stroke had occurred. nonfatal stroke occurred in 2%, and tia occurred in 1%. there was no perioperative mortality ...20113059211
blood glucose control and diabetic complications.two hypotheses have been advanced to explain the appearance of microvascular complications in diabetic patients with glycemic control. the genetic hypothesis suggests that the development of diabetic complications is genetically determined and independent of diabetic control, whereas the metabolic hypothesis suggests that long-term hyperglycemia causes the subsequent development of small-blood-vessel complications. we review data that either support or reject these hypotheses and suggest a third ...20123524339
the hemostatic mechanism: the role of platelets in physiology and bleeding states.the most recent information about platelets and their role in hemostasis is presented. the intimate cooperation between platelets, coagulation, and the vessel wall (the thrombohemorrhagic balance) is outlined. clinical correlates (congenital and acquired bleeding states) to the various physiological stages and the possible effects on hemostasis of the unique acidic environment of the stomach are briefly discussed.20123321399
alpha-fetoprotein in the treatment of primary liver cancer. 20144140256
[letter: teratogenic hazards in antiepileptic therapy]. 20164815439
phase i study of a new antianxiety drug, buspirone.1. a phase i study of buspirone was conducted in 7 healthy male volunteers. 2. diazepam was selected as the control drug and administered in equipotent doses to buspirone. dosage was initiated at 2.5mg and doubled until a maximum dosage of 20mg was attained. subsequently, 10mg was administered once a day for three consecutive days. 3. clinico-pharmacologically both drugs produced sleepiness/drowsiness, but dizziness, light-headed feeling and feeling of drunkenness were marked only in the diazepa ...20052748857
comparison of analytical methods for residual ethylene oxide analysis.a round-robin study compared four methods of residual ethylene oxide analysis. results from the six participating laboratories, along with a statistical treatment of the data, are presented.20051151720
the effect of six months continuous subcutaneous insulin infusion on kidney function and size in insulin-dependent diabetics.glomerular filtration rate (gfr), renal plasma flow (rpf), kidney volume, and urinary albumin excretion rate were measured in 24 insulin-dependent diabetics, aged 29 +/- 7 years (mean +/- s.d.) of 8 +/- 4 years duration, randomly allocated to either continuous subcutaneous insulin infusion (csii) (n = 12) or unchanged conventional insulin treatment (cit) (n = 12). glomerular filtration rate, renal plasma flow, and kidney volume were identical in the two groups at the start of the study, although ...20092951131
ataxia-telangiectasia and hepatocellular carcinoma.ataxia-telangiectasia (at) is a multi-system disease involving the cerebellum, cutaneous blood vessels and the immune system including both cellular and humoral components. it also involves hematological, endocrine and peripheral nervous systems. this disease is often associated with abnormal liver function tests, such as, raised alkaline phosphatase and various nonspecific histological changes in the liver. high incidence of various malignancies involving lymphoreticular, gastrointestinal and m ...200192892
[bone marrow necrosis. apropos of 2 cases]. 20072933830
pet in generalized anxiety disorder.positron emission tomography (pet) measurements of cerebral glucose use were made in 18 patients with generalized anxiety disorder (gad) during a passive viewing task off medication, and an active vigilance viewing task before and after medication or placebo treatment. in the passive viewing task, patients with gad were compared with 15 normal controls. a significant difference in pattern of absolute brain metabolism was found. patients showed lower absolute metabolic rates in basal ganglia and ...20071888800
[follow-up study of a clientele receiving sick-leave maintenance allowances for limited periods]. 20143976070
effects of overfeeding on lipid and carbohydrate metabolism in lean young adults. 20165047918
[amalgam discussion. question of amalgam toxicity and allergy]. 20072171028
lightness, embeddedness, and contrast. 20075054071
american academy of pediatrics: prep statement. 20082587145
[tumoral hypocalcemia].hypocalcemia is a rare and not well understood paraneoplasic manifestation. we report the clinical case of a patient with hypocalcemia due to extensive osteoblastic metastasis. the corrected serum calcium levels for albumin was 7.2 mg/dl. calciuria was less than 10 mg/24 h. magnesium, phosphate and 25-hydroxyvitamin d levels were normal. pth and 1,25-dihydroxyvitamin d levels were increased. the pathogenesis of this disorder is possibly related to the massive calcium flow toward metastatic areas ...20092740546
the need for a more robust ozone air quality standard.the present national ambient air quality standard for ozone has many statistical problems, including use of extreme values which have inherent large fluctuations, a compliance test that can gradually lower the target of the design value below the standard level, and inconsistencies between the number-of-exceedances criterion and the design value. the above problems can be avoided or minimized by using a more robust statistic, such as the 95th percentile, and applying a statistical compliance tes ...20102795112
[appraisal of the radiation changes and metastatic lesions of the lymphatic system of the pelvis with the aid of lymphography]. 20144301018
endogenous formation of carbon monoxide and methane at elevated pressure. 20144150747
case finding of heart disease in homeless men. 20154513122
[decreasing the emission of pollutants in laboratory waste water by substitution of trichloromethane].working up great test series to determine chloroform-extractive substances and tensides, increased trichlormethane concentrations can appear in the laboratory air-inspite of realization of numerous precautionary measures. as a rule the makd rate will be exceeded than. various precautions failed to fulfill their purpose so that the solvent trichlormethane had been replaced by other solvents. two demands mainly influenced on this replacement. the risk to health must be decreased so far that the wo ...20092741501
stress fracture of the rib in an elite oarsman.this paper documents an unusual case of a stress fracture of the ninth rib in an elite oarsman. a 25-year-old male presented with a 3-day history of right-sided chest pain aggravated by deep inspiration and movements simulating rowing. the athlete was treated initially as having a soft tissue injury; however, a technetium-99 bone scan confirmed the diagnosis. routine radiographs of the ribs were negative. the pain and symptoms were confined to the anatomical area of the fracture along the antero ...20092777439
francis thomas garnet prunty. 199890912
[4 cases of calcifying pancreatitis in hemochromatosis]. 20154314829
[current therapeutic trends in hemometakinetic syndromes. preliminary note]. 1998108627
characteristics of drosophila rhodopsin in wild-type and norpa vision transduction mutants.the properties of the major visual pigment of drosophila melanogaster were evaluated. the visual pigment was isolated from other protein components using acrylamide gel electrophoresis and spectral identification. sodium dodecyl sulfate (sds) acrylamide gels of the isolated visual pigment gave a single protein subunit with a mol wt of 37,000 daltons. the rhodopsin480 molar extinction coefficient was 35,000 liter/mol-cm (+/- 2,700 se). the metarhodopsin580 molar extinction coefficient was approxi ...1998105082
shattuck lecture--in the public interest. 1998107452
platelet aggregation in experimental spinal cord injury. ultrastructural observations.endothelial alterations occur as early as 1 1/2 minutes following impact injury to the primate spinal cord. separation of the endothelial junctions and exposure of microvascular basal lamina result in platelet adhesion and aggregations that cover defects in the vessel wall and may progress to complete vascular occlusion. this occurs during the first six hours following injury. platelets also adhere to the surface of damaged endothelium. hemostasis resulting from platelet thrombus formation is re ...1998106810
[principles of hemophilia self-treatment. discussion of experience at german hemophilia centers heidelberg, january 22 and june 3--4, 1977]. 1998107986
[pancreatic carcinoma on endoscopic retrograde pancreatico-cholangiogram (author's transl)].the pancreaticographic appearances of carcinoma of the pancreas have been divided into two types: 1. canalicular carcinoma arising from the duct system. if arising from the main pancreatic duct, it occludes this, or causes displacement or deformity of its branches in the immediate neighbourhood. if arising from branches, it causes cystic ectasia of the minor ducts; these appear fragmented and deformed while there is stenosis and displacement of the main duct. simultaneous origin from the main an ...1998124684
substrate specificity of hexosaminidase a isolated from the liver of a patient with a rare form (ab variant) of infantile gm2 gangliosidosis and control tissues. 199996668
[retinal neovascularization: topological, morphological and hemodynamic features (author's transl)]. 199991317
incidence of prostatic calcification in blacks in washington, d.c., and selected african cities. correlation of specimen roentgenographs and pathologic findings. cooperative prostatic research group.the incidence of calcification in the prostate gland of black men from washington, d.c., and from ibadan, nigeria, and accra, ghana, west africa, was assessed in a total of 874 consecutive, unselected prostate specimens removed at autopsy during a five-year period (1973--1978). in the combined series there was a significant positive association between prostatic calcification and age (p less than 0.001). the frequency of calcification was significantly higher in the washington, d.c. series than ...199991253
haloperidol and lithium blocking of the mood response to intravenous methylphenidate.the euthymic manic-d-pressive patients with therapeutic plasma lithium levels were each given two i.f. infusions of 30 mg of methylphenidate. the infusions were separated by at least 3 days. before one infusion each patient was given 5 mg of haloperidol i.v. and before the other infusion each was given an identical volume of saline. a psychiatric observer was blind to the nature of the pretreatment and the order of pretreatment was randomized. saline pretreated patients showed marked activation ...199996473
primary care approaches to developmental disabilities.ninety-seven board certified pediatricians who spend at least 75% of their professional working hours involved in the delivery of primary care in new england were interviewed to explore their attitudes and current clinical approaches to developmental disabilities. the majority of the pediatricians relied exclusively on clinical judgment and general observations for assessing developmental problems in their offices. responsibility for preschool screening for potential learning problems and the as ...199991155
unmasking of fetal determinants on adult bone marrow cells. 199991109
sterilisation issues.exception is taken to the 2 bases for sterilization of mentally handicapped people as stated by the working group in current medical/ethical problems -- genetic and fitness for parenthood. although parents with certain forms of retardation have a greater genetic propensity to bear mentally retarded offspring, there are considerably more "normal" parents with as high or a greater propensity. 80-90% of mentally handicapped children are born to normal parents. the unfitness for parenthood rationale ...199991007
retinol-binding protein in malnutrition. 199990984
esophagogastrectomy for carcinoma of the middle third of the esophagus.elective esophagogastrectomy and reconstruction by esophagogastrostomy were performed on 55 patients with malignant tumors of the midesophagus, despite invasion of contiguous structures in 60% and regional lymph node involvement in 75%. the operations were invariably palliative. two patients died within thirty days of operation. dysphagia was relieved and oral alimentation resumed in the other 53. twenty-nine patients who had experienced painful swallowing and 16 who had vomiting obtained relief ...200092220
steroids in asthma. 200091910
consistency of autoradiographic dna repair in cells treated "in vitro" with n-diazoacetylglycine amide. a preliminary approach to quantitate the absolute amount of dna repair. 200198772
[medical management of tachycardias (author's transl)].guidelines for a step-wise plan of treatment of tachycardias have been compiled based on clinical empirical experience and with the aid of surface electrocardiograms, intracardial electrograms and stimulation techniques. the plan is primarily with the aid of surface electrocardiograms, intracardial electrograms and stimulation techniques. the plan is primarily oriented with respect to the antiarrhythmic efficacy, the adverse reactions and the practicability of the respective agents. any type of ...200193075
visual aids in nutrition education. a guide to their preparation and use. 200195011
[volvulus of the afferent loop after billroth ii operation (author's transl)].a case report is given of a patient, who had a volvulus of the afferent loop after billroth ii operation; on relaparotomy it was found, that this loop had slipped cranially through the mesocolic slit, twisted, and become gangreneous, due to bad adjustement of the slit. increased levels of serum amylase initially had given rise to the suspicion, that the deteriorating condition of the patient was due to pancreatitis. the patient recovered fully after resection had been done and an y-roux-anastomo ...200194934
editorial: health care crisis. 2002124076
[acid glycosaminoglycans in localized pleural mesothelioma--histochemical and biochemical study]. 2002135110
normal and abnormal upper abdominal venous structures as seen by ultrasound.recent b-scan ultrasonic techniques have made possible the routine visualization of the major upper abdominal venous structures. real-time scanning permits in vivo dynamic assessment of the upper abdominal veins. b-scan ultrasound allows optimal anatomic resolution and is superior for the establishment of intraluminal pathology and anatomic relationships with adjacent organs. the anatomic localization of the upper abdominal veins has proved of practical importance in several ways. identification ...2003403799
[protein concentrations in the ejaculate of patients with chronic prostatitis].in 158 patients suffering from chronic prostatitis and 23 healthy men seminal fluid concentrations of igg, iga, c3c, coeruloplasmin, alpha-1-antitrypsin and alpha-1-glycoprotein were determined by immunodiffusion. concentration of igg is closely correlated to leucocyte counts, that of igg, c3c, and coeruloplasmin to erythrocyte counts. c3c, coeruloplasmin, alapha-1-glycoprotein and alpha-1-antitrypsin are further correlated to sperm counts. igg and c3c concentrations are related to pathogenetic ...2003309878
[nurse's role in the organization of diagnostic studies]. 2003254370
from the clinic: back school. 2003155392
[blood pressures in gestosis patients under general anaesthesia following hypotensive treatment (author's transl)].a retrospective evaluation was made of the blood pressures of 131 patients with hypertensive late gestosis who had undergone caesarean section for maternal or foetal indications, between 1971 and 1977. rauwolfia preparations should be avoided in both long-term and acute hypotensive treatment of late gestosis patients not only for their unfavourable impact upon circulation at large, but also for their cumulative effects in terms of drastic depression of blood pressure in case of anaesthesia neces ...2004532434
exercise prescription--north american experience.the principles of exercise prescription are reviewed with respect to north american experience. the required regimen must be safe, therapeutically effective, and ensure a high rate of compliance. precautions to increase the safety of exercise are discussed. cardiac emergencies are sufficiently rare events (less than 1 in 200,000 hours even in post-coronary classes) that the need for immediate medical supervision of a well-designed programme can be questioned. the prime determinant of the respons ...2004444812
misuse of drugs in sport. 2004444805
surgical removal of a left atrial myxoma during pregnancy.successful removal of a left atrial myxoma in a pregnant woman has not been previously reported. the patient postoperatively had an uncomplicated pregnancy, delivering at term a normal, healthy baby.2004421587
how can teachers learn to respond effectively to their students? 2004470754
[problems of special epidemiological risk areas in public health and social workers]. 2004463074
[study of the pulmonary vessel reaction to administration of carbon dioxide and nitroglycerin in congenital heart defects complicated by high pulmonary hypertension].the results of functional pharmacological tests with nitroglycerine and carbon dioxide gas are presented for patients with congenital heart diseases and pulmonary hypertension, as shown during right heart catheterization. it was established that nitroglycerine, taken sublingually, does not produce any direct effect on the pulmonary artery pressure, and the delayed changes in haemodynamics are a consequence of the altered regimen of pressure in the general circulation. when carbon dioxide gas was ...2004404459
20 years investigations on cytochrome p-450. 2004356059
the influence of experimental gingivitis on plaque formation.the rate of plaque growth was assessed using daily plaque index measurements over a 7-day period in eleven dental students with an initial mean gingival indes of 1.21 (+/- 0.05). the mean gingival index was then reduced to 0.27 (+/- 0.04) and the rate of plaque growth assessed in the same way. bacterial smears were taken from the teeth at intervals during both experimental periods and percentage counts of various morphological types of bacteria made. the rate of plaque growth was found to be sig ...2004321485
[achievements in gastric surgery in ukraine during 60 years of the soviet rule]. 2004342803
[testicular cavernous lymphangioma in a 13-year-old boy]. 20051273002
[drug pulverizer with a spatula]. 20051231142
[instrument for trephine puncture of the frontal sinus]. 20051231141
[conduction anesthesia in operations on the scrotum and its organs]. 20051231119
[letter: adverse effects of antiepileptic drugs]. 20051183340
ly phenotype of t-cells releasing t-cell replacing factor. 20051087370
[pharmacological suppression of hyperparathyroidism in patients treated by periodical hemodialysis. histological, hormonal, biochemical and radiological study]. 20051087389
histopathology of the joint. 20051064947
scda policy on continuing education. 20051064924
[an unusual case of entero-vesical fistula caused by a foreign body].the authors describe a rare case of sigmoidovesical fistula due to a foreign body and giving trouble 30 years after the causative surgical procedure, namely an oopheroctomy. the cause of the fistula was apparently some suture material that had not been reabsorbed. surgical excision of the fistula produced a complete recovery.2005546533
a simple centrifuge column for desalting protein solutions. 2005543535
[lipid metabolism disorders: diagnosis and treatment. 4: drug therapy and dietary recommendations. national cholesterin-initiative]. 20061855762
[lipid metabolism disorders: diagnosis and treatment. 4: drug therapy and dietary recommendations. national cholesterin-initiative]. 20061855762
a role for nmr in alcoholism? 20061796991
a role for nmr in alcoholism? 20061796991
serum autoantibodies in patients with alzheimer's disease and vascular dementia and in nondemented control subjects.in this study we sought to evaluate the clinical significance of serum autoantibodies to dementing processes.20061636181
rubber-specific ige in children with spina bifida: identification and management. 20061489746
m net: a statewide referring physician computer network.m net, the referring physician computer network, is a joint project between the university of michigan medical center (ummc) and ibm. a graphical user interface was developed to allow referring physicians easy access to a variety of patient, clinical, and institutional data. file transfer mechanisms were created and current clinical database files and programs were enhanced and restructured to facilitate remote data transmission. m net is currently installed in referring physician office sites a ...20061482996
mao inhibitors and coronary artery surgery: a patient death.the mechanisms of action of monoamine oxidase inhibitors (maois) suggest that patients taking them may respond with hyper- or hypotension when undergoing coronary artery surgery. we describe a case where maois were present and fentanyl and midazolam were the anaesthetic agents used. the anaesthesia and surgery were performed without incident. postoperative icu care was complicated by hypertension, hyperthermia, and severe shivering followed by hypotension resistant to therapy and finally death. ...20061464133
[the hemostatic system in traumatic subarachnoid hemorrhage in the far north].it was found that in conditions of the extreme north sanation of the cerebrospinal fluid occurs later in patients with traumatic subarachnoidal hemorrhage than in the central regions of the country. in connection with this the hemostasis system was studied in 20 patients with traumatic subarachnoidal hemorrhage and 10 patients with brain tumours (control group). patients with traumatic subarachnoidal hemorrhage showed significant hypocoagulation changes.20061448989
comparing and optimizing diagnostic tests: an information-theoretical approach.an ideal method for assessing performance of non-binary diagnostic tests would specify each test's optimal operating point and would tell a diagnostician which of many tests was the best one to use in a particular clinical situation. this article shows how information theory and receiver operating characteristic (roc) analysis can be combined to evaluate and compare diagnostic tests at their optimum cutoffs once disease prevalence and test properties are specified. though it is not appropriate f ...20061513208
proteins of photosystem 1 during chloroplast assembly and senescence in festuca pratensis. 20061426570
health checks on patients 75 years and over in nottinghamshire after the new gp contract.to investigate annual health checks for patients of 75 years and over required by the 1990 contract for general practitioners.20061393076
[evaluation of the effect of proton pump inhibitors on stomal ulcer].four reports on proton pump inhibitors related to the clinical effects on stomal ulcer were reviewed. two reports were on omeprazole and the other two on lansoprazole, carried out in the pre-marketing stage. they are compared with two reports on h2-receptor antagonists (famotidine and ranitidine), which were also done in the pre-marketing stage. it appears that the proton pump inhibitors bring more rapid ulcer healing than h2-receptor antagonists without severe side effects, and there seems to b ...20061347326
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