| virulence factors and tem-type β-lactamases produced by two isolates of an epidemic klebsiella pneumoniae strain. | two klebsiella pneumoniae isolates of the same strain, identified in poland, produced either tem-47 or tem-68, which differed by the arg275leu substitution. they harbored a few virulence factors, including an iron-chelating factor and capsule overproduction, suggesting that these factors were sufficient to enhance their nosocomial potency. tem-68 and tem-47 had similar enzymatic activities, but tem-68 was less susceptible to inhibitors than tem-47. these results confirm the role of the arg275leu ... | 2011 | 22106220 |
| evolution of inca/c blacmy-2-carrying plasmids by acquisition of the blandm-1 carbapenemase gene. | the bla(ndm-1) gene has been reported to be often located on broad-host-range plasmids of the inca/c type in clinical but also environmental bacteria recovered from the new delhi, india, area. inca/c-type plasmids are the main vehicles for the spread of the cephalosporinase gene bla(cmy-2), frequently identified in the united states, canada, and europe. in this study, we completed the sequence of inca/c plasmid pndm-kn carrying the bla(ndm-1) gene, recovered from a klebsiella pneumoniae isolate ... | 2011 | 22123704 |
| early mortality and retinopathy of prematurity: report of 2 cases. | | 2011 | 21995996 |
| Increasing burden of hospital acquired infections: resistance to cephalosporin antibiotics among klebsiella and Escherichia coli. | The drug susceptibility pattern of klebsiella species and Escherichia coli to cephalosporins was examined in the year 2004 and 2005. A total of 180 klebsiella and 220 E coli in 2004 and 95 klebsiella and 210. E coli in the year 2005, isolated from various clinical specimens were studied. Resistance rates among the klebsiella species, ranged from 50.00%-86.36% and 42.10%-84.21% in 2004 and 2005 respectively. Resistance rates among E coli ranged from 46.66%-90.8% and 50.0%-86.66% in 2004 and 2005 ... | 2011 | 22010583 |
| resistance pattern of ciprofloxacin against different pathogens. | ciprofloxacin is a broad-spectrum antibiotic widely prescribed in clinical and hospital settings. the emergence of antimicrobial resistance against effective antibiotics is a global issue. the objective of study is the surveillance of ciprofloxacin against common pathogens. | 2010 | 22043361 |
| Comparison of disc diffusion, Etest and agar dilution for susceptibility testing of colistin against Enterobacteriaceae. | In this study, we compared different methods of colistin susceptibility testing, disc diffusion, agar dilution and Etest using a set of Enterobacteriaceae isolates that included colistin-resistant strains. | 2011 | 21895730 |
| Colonization and infection by colistin-resistant Gram-negative bacteria in a cohort of critically ill patients. | In recent years there has been renewed interest in colistin for the treatment of infections by multidrug-resistant Gram-negative bacteria, causing concern that increasing use may be accompanied by the emergence of resistance. This is a retrospective cohort study of colonization and infection by colistin-resistant (CR) gram-negative bacteria in critically ill patients. Colonization data were based on surveillance culture results. Among 150 patients, 78 (52%) were colonized by CR Gram-negative bac ... | 2011 | 21939468 |
| Isolation and identification of antibacterial compound from the leaves of Cassia auriculata. | Antimicrobial properties of medicinal plants and plant parts such as flowers, roots, fruits, seeds and oils are being used to cure some chronic and acute diseases throughout the world. In the present study, an attempt has been made to isolate and identify the antibacterial compound present in the leaves of the Cassia auriculata. | 2011 | 22013726 |
| Long pentraxin 3 (PTX3) in the light of its structure, mechanism of action and clinical implications. | Pentraxins are a group of evolutionarily conserved ancient proteins. Depending on their structure, pentraxins are divided into short and long pentraxin families. Pentraxin 3 (PTX3) is the prototype of the long pentraxin group. PTX3 synthesis is stimulated by a variety of molecules involved in the inflammatory process. The inflammatory mediator is typically produced at inflammatory sites; however, it can also be released at the sites remote from the original inflammatory insult. Although mainly e ... | 2011 | 21988562 |
| influence of consumption of probiotics on presence of enterobacteria in the oral cavity. | clinical benefits of probiotics have been clearly reported in different gastrointestinal disorders, many of them caused by enterobacteria. the oral cavity is a port of entry and can be an important reservoir of these microorganisms. this work evaluated whether consumption of probiotics was able to influence the presence of enterobacteria in the oral cavity and the specific secretory response against these microorganisms. saliva samples of healthy individuals were collected and plated in macconke ... | 2011 | 22031052 |
| synthesis, spectroscopic properties and antipathogenic activity of new thiourea derivatives. | a number of acylthioureas, 2-((4-methylphenoxy)methyl)-n-(aryl-carbamothioyl)benzamides (aryl = 3,5-dichlorophenyl, 2,3-dichlorophenyl, 3,4-dichloro-phenyl, 2,4,5-trichlorophenyl, 3,4,5-trichlorophenyl, 2-bromophenyl, 2,4-dibromophenyl, 2,5-dibromophenyl, 2-iodophenyl, 3-fluorophenyl, 2,3,4-trifluorophenyl, 2,4,5-trifluoro-phenyl, 2,4,6-trifluorophenyl) have been synthesized, characterized by elemental analysis, ir and nmr spectroscopy and tested for their interaction with bacterial cells in fre ... | 2011 | 21900862 |
| Nosocomial Outbreak of VIM-1-Producing Klebsiella pneumoniae Isolates of Multilocus Sequence Type 15: Molecular Basis, Clinical Risk Factors, and Outcome. | We study the epidemiology, molecular basis, clinical risk factors, and outcome involved in the clonal dissemination of VIM-1-producing Klebsiella pneumoniae isolates in the hospital setting. All patients infected/colonized by carbapenem-nonsusceptible K. pneumoniae (CNSKP) in 2009 were included. Molecular epidemiology was studied by pulsed-field gel electrophoresis (PFGE) and multilocus sequence typing (MLST). Antibiotic resistance genes were analyzed by PCR and sequencing. Plasmids were studied ... | 2012 | 22005997 |
| biochemical characterization of the tem-107 extended-spectrum β-lactamase in a klebsiella pneumoniae isolate from south korea. | the tem-107 extended-spectrum β-lactamase detected in a klebsiella pneumoniae clinical isolate had a gly238ser substitution compared to the tem-43 β-lactamase. the mic of ceftazidime was higher (64 μg/ml) than that of cefotaxime (2 μg/ml) for the isolate. clavulanic acid reduced the mic of ceftazidime 64-fold. | 2011 | 21911565 |
| [Five years following of infections with extended-spectrum beta-lactamase producing enterobacteriaceae]. | Actually, epidemiology of extended-spectrum ß-lactamase (ESBL) producing enterobacteriaceae is increasing worldwide, especially in urinary tract infections (UTI). The objective of the study was to investigate the epidemiology of ESBL producers in a department of urology. | 2012 | 22196001 |
| Development of TaqMan real-time polymerase chain reaction for the detection of the newly emerging form of carbapenem resistance gene in clinical isolates of Escherichia coli, Klebsiella pneumoniae, and Acinetobacter baumannii. | The newly emerging form of the so-called New Delhi Metallo-beta-lactamases (NDM-1) has been reported recently from patients worldwide and broadly thought as a potential source for the major global health problem. Thus, it is important to study the epidemiology of the so-called NDM-1 harbouring bacteria to prevent its further spread and to place effective control measures. The present study describes the use of the real-time polymerase chain reaction (PCR) assay for the detection of the bla NDM-1 ... | 2011 | 21860104 |
| high rates of intestinal colonization with extended-spectrum lactamase-producing enterobacteriaceae among healthy individuals. | infections caused by extended-spectrum β-lactamase (esbl)-producing bacteria become an emerging problem in the community setting in many parts of the world. | 2011 | 22068018 |
| [pneumonia-causing bacterial pathogens in intensive care patients]. | this prospective study aimed at determining etiologic agents causing nosocomial pneumonia in a precisely defined group of patients and resistance of bacterial pathogens to antimicrobial drugs. | 2011 | 22052100 |
| multidrug-resistant bacterial colonization of combat-injured personnel at admission to medical centers after evacuation from afghanistan and iraq. | multidrug-resistant organism (mdro) infections, including those secondary to acinetobacter (acb) and extended spectrum β-lactamase (esbl)-producing enterobacteriaceae (escherichia coli and klebsiella species) have complicated the care of combat-injured personnel during operations iraqi freedom and enduring freedom. data suggest that the source of these bacterial infections includes nosocomial transmission in both deployed hospitals and receiving military medical centers (medcens). admission scre ... | 2011 | 21795879 |
| Clinical and bacteriological characteristics of Klebsiella pneumoniae causing liver abscess with less frequently observed multi-locus sequences type, ST163, from Singapore and Missouri, US. | BACKGROUND: Klebsiella pneumoniae is the major cause of liver abscesses in several Asian countries. Differences in the type of circulating Klebsiella strains and/or the genetic make up of the host seem to be plausible explanations for this. METHODS: Two recent K. pneumoniae strains isolated from patients with liver abscess, one from Missouri in the US, and a second one from Singapore, were fully characterized by molecular typing, association of virulent genes, neutrophil phagocytosis, susceptibi ... | 2011 | 22138655 |
| Real-time PCR Analysis of Intestinal Microbiota in Peritoneal Dialysis Patients. | Bifidobacterium and Lactobacillus can beneficially affect the host by producing acetic acid and lactic acid which lower pH and thereby inhibits the growth of pathogens or by competing with pathogens for epithelial adhesion sites and nutrients. The transmural migration of enteric organisms into the peritoneal cavity can cause peritonitis in peritoneal dialysis (PD) patients. We hypothesized that the intestinal microbiota such as Lactobacillus species and Bifidobacterium species differed between P ... | 2011 | 22179250 |
| Efficacy of Pivmecillinam for Treatment of Lower Urinary Tract Infection Caused by Extended-Spectrum ß-Lactamase-Producing Escherichia coli and Klebsiella pneumoniae. | To evaluate the clinical and bacteriological efficacy of pivmecillinam against lower urinary tract infection (UTI) caused by extended-spectrum ß-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae, patients treated for lower UTI with pivmecillinam (n=8) were studied. Patients treated with nitrofurantoin (n=3) and trimethoprim (n=3) or a combination of these agents with pivmecillinam (n=3) were included as a control group. Antimicrobial susceptibility was determined with EUCAST ... | 2011 | 22204597 |
| In vivo antibacterial activity of chinfloxacin, a new fluoroquinolone antibiotic. | OBJECTIVES: To evaluate the in vivo antibacterial efficacy of chinfloxacin, a novel fluoroquinolone, in murine systemic and local infection models. METHODS: The efficacy of chinfloxacin in systemic infection was evaluated in a mouse peritonitis model using isolates of methicillin-susceptible Staphylococcus aureus (MSSA, n?=?3), methicillin-resistant Staphylococcus aureus (MRSA; n?=?1), penicillin-intermediate Streptococcus pneumoniae (PISP; n?=?1), penicillin-resistant S. pneumoniae (PRSP; n?=?2 ... | 2011 | 22210757 |
| Dissemination of the Klebsiella pneumoniae Carbapenemase in the Health Care Settings: Tracking the Trails of an Elusive Offender. | ABSTRACT Transmission of antibiotic resistance genes may be mediated by a variety of molecular mechanisms, from mobility of small genetic elements to clonal spread. Since 1997, the carbapenem-hydrolyzing enzyme Klebsiella pneumoniae carbapenemase (KPC) has spread in the United States and across the world, mainly via a single K. pneumoniae clone, sequence type 258. By tracking the trail of dissemination of the bla(KPC) gene inside their institution, Mathers et al. (mBio 2:e00204-11, 2011) have sh ... | 2011 | 22186612 |
| emergence and risk factors of β-lactamase-mediated resistance to oxyimino-β-lactams in enterobacteriaceae isolates. | we studied 193 enterobacteriaceae isolates presenting diminished susceptibility to oxyimino-cephalosporins recovered in a portuguese hospital (2004-2008). ctx-m-3 producers, firstly detected in portugal, were associated with a klebsiella pneumoniae microepidemic clone. production of ctx-m-type enzymes (ctx-m-1/-3/-9/-14/-15/-32), age ≥65 years, and nosocomial infection were risk factors for higher nonsusceptibility to oxyimino-β-lactams. cmy-2 and dha-1 β-lactamases were only identified in 1% of ... | 2011 | 22209509 |
| functional and phenotypical alterations of polymorphonuclear cells in sézary syndrome patients. | sézary syndrome (ss), the leukemic variant of cutaneous t-cell lymphoma (ctcl), has a poor prognosis and infections represent the most frequent cause of death. polymorphonucleate granulocytes (pmns) constitute an essential part of the innate immune system: their phagocytic and killing activity against pathogens is mediated by the interactions between toll-like receptors (tlrs) and the pathogen-associated molecular patterns (pamps). the aim of this study was to investigate pmn functional activity ... | 2011 | 21951393 |
| Activity of Polymyxin B and the Novel Polymyxin Analogue CB-182,804 Against Contemporary Gram-Negative Pathogens in New York City. | Multidrug-resistant Acinetobacter baumannii, Klebsiella pneumoniae, and Pseudomonas aeruginosa have become common in many regions, often requiring therapy with colistin or polymyxin B. An increase in resistance to these agents would render many infections untreatable. We tested the activity of polymyxin B and the novel polymyxin analogue CB-182,804 against over 5,000 recent Gram-negative clinical isolates from New York City, a region with a high prevalence of multiresistant strains. Over 96% of ... | 2011 | 22196342 |
| defense role of the cocoon in the silk worm bombyx mori l. | silk from the domesticated silk worm bombyx mori procures foreign body response naturally, so it has been utilized as a biomaterial for decades. in india the prime focus of the sericulture industry is to improve silk production with high quality silk. naturally, the silk worm builds its cocoon not only with silk proteins, but also with antimicrobial proteins to avoid infection since the cocoon is non-motile and non-feeding. the aim of the present study is to elucidate the antimicrobial proteins ... | 2011 | 22006381 |
| rapidly fatal community-acquired pneumonia due to klebsiella pneumoniae complicated with acute myocarditis and accelerated idioventricular rhythm. | we describe a previously healthy 52-year-old man with rapidly fatal community-acquired pneumonia caused by klebsiella pneumoniae. the patient developed acute renal dysfunction, accelerated idioventricular rhythm (acute myocarditis), lactic acidosis and septic shock. he died within 15 hours after admission despite intravenous levofloxacin (750 mg daily) and aggressive medical treatment. | 2011 | 22153763 |
| european dissemination of a single oxa-48-producing klebsiella pneumoniae clone. | a klebsiella pneumoniae isolate with decreased susceptibility to carbapenems was isolated in april 2011 in a hospital in amsterdam (the netherlands) and later found to be the source of an important outbreak in a rotterdam hospital. the strain, belonging to sequence type (st) 395, carried the bla(oxa-48) gene located onto a c 62-kb conjugative plasmid, together with the extended-spectrum β-lactamase gene bla(ctx-m-15) . it was closely related or identical to other oxa-48-positive klebsiella pneum ... | 2011 | 21973185 |
| use of meropenem by continuous infusion to treat a patient with a bla(kpc-2)-positive klebsiella pneumoniae blood stream infection. | gram-negative bacterial resistance to antibiotics is of increasing concern. carbapenem resistance among strains of klebsiella pneumoniae is a relatively new phenomenon. resistance attributable to production of carbapenemases is notoriously difficult to combat. | 2011 | 21859337 |
| phytochemical constituents and antibacterial efficacy of the flowers of peltophorum pterocarpum (dc.) baker ex heyne. | to investigate the preliminary phytochemistry and antibacterial activity of the flower extract of peltophorum pterocarpum . | 2011 | 21967698 |
| identification of plasmid-mediated quinolone resistance genes qnra1, qnrb1 and aac(6')-1b-cr in a multiple drug-resistant isolate of klebsiella pneumoniae from chennai. | resistance to fluoroquinolones, a commonly prescribed antimicrobial for gram-negative and gram-positive microorganisms, is of importance in therapy. the purpose of this study was to screen for the presence of plasmid-mediated quinolone resistance (pmqr) determinants in clinical isolates of klebsiella pneumoniae. | 2011 | 21860107 |
| tannin extracts from immature fruits of terminalia chebula fructus retz. promote cutaneous wound healing in rats. | tannins extracted from immature fruits of terminalia chebula fructus retz. are considered as effective components promoting the process of wound healing. the objective of this study is to explore the optimal extraction and purification technology (oept) of tannins, while studying the use of this drug in the treatment of a cutaneous wound of rat as well as its antibacterial effects. | 2011 | 21982053 |
| predictors of in-hospital mortality in elderly patients with bacteraemia admitted to an internal medicine ward. | abstract: | 2011 | 21970460 |
| a multifaceted intervention strategy for eradication of a hospital-wide outbreak caused by carbapenem-resistant klebsiella pneumoniae in southern israel. | to devise a local strategy for eradication of a hospital-wide outbreak caused by carbapenem-resistant klebsiella pneumoniae (crkp). | 2011 | 22080653 |
| a randomized, double-blind, placebo-controlled trial of selective digestive decontamination using oral gentamicin and oral polymyxin e for eradication of carbapenem-resistant klebsiella pneumoniae carriage. | to assess the effectiveness of selective digestive decontamination (sdd) for eradicating carbapenem-resistant klebsiella pneumoniae (crkp) oropharyngeal and gastrointestinal carriage. | 2012 | 22173517 |
| Detection of Citrobacter koseri carrying beta-lactamase KPC-2 in a hospitalised patient, Greece, July 2011. | This report describes the detection of Citrobacter koseri carrying K. pneumoniae carbapenemase (KPC-2) isolated in July 2011 from a Greek patient, who was also colonised by a Klebsiella pneumoniae strain coproducing KPC-2 and Verona integron-encoded metallo-beta-lactamase (VIM)-1. | 2011 | 22008199 |
| [Review of the effectiveness of an empirical antibiotic therapy in suspected ventilator-associated pneumonia]. | Ventilator-associated pneumonia (VAP) occurs in approximately 10-20% of mechanically ventilated patients, and is associated with an extremely high mortality rate (up to 70%). The purpose of the study was to determine the susceptibility spectrum of Klebsiella, Pseudomonas and Acinetobacter strains isolated from VAP patients. | 2011 | 22011920 |
| Comparative study of antimicrobial activity and phytochemical analysis of methanolic and aqueous extracts of the fruit of Emblica officinalis against pathogenic bacteria. | To investigate antimicrobial potential of aqueous (infusions, decoctions) and methanlic extracts (1:2 and 1:5 concentrations) of Emblica officinalis (amla) against seven pathogenic bacteria namely Staphylococcs aureus, Staphylococcus saprophyticus, Escherichia coli, Enterococcus faecalis, Enterococcus cloacae, Proteus vulgaris and Klebsiella pneumoniae. | 2011 | 21977871 |
| The characteristics of NDM-producing Klebsiella pneumoniae from Canada. | After recent hospitalization in India (New Delhi and Mumbai), 2 patients, on their return to Canada, presented with lower urinary tract infections due to multiresistant Klebsiella pneumoniae that produced New Delhi metallo-ß-lactamase and CTX-M-15. The organisms belonged to clones ST147 and ST340, and were positive for aac(6')-Ib-cr, as well as for the ccdAB and vagCD addiction systems. The bla(NDM) plasmid was located on the IncFIIA and IncA/C replicon groups of plasmids. Clones ST147 and ST340 ... | 2011 | 21924993 |
| in vitro activity of tigecycline and comparators against gram-negative bacteria isolated from a tertiary hospital in alexandria, egypt. | the emergence of infections caused by multidrug-resistant gram-negative bacteria, in particular pseudomonas aeruginosa, acinetobacter baumannii, and klebsiella pneumoniae, has necessitated the search for alternative therapy by either introducing new agents or renewing interest in old agents. this study compares the in vitro activity of tigecycline (tig), recently introduced to egyptian market, to other potentially active antimicrobials as colistin (col), imipenem (ipm), levofloxacin (lev), and p ... | 2011 | 21875338 |
| Synthesis and antimicrobial properties of naphthylamine derivatives having a thiazolidinone moiety. | The aim of this study was to evaluate the influence of pharmacophores having naphthylamine and nitro groups on the antimicrobial (antibacterial and antifungal) activity of thiazolidinone derivatives. | 2011 | 21968886 |
| The priB gene of Klebsiella pneumoniae encodes a 104-amino acid protein that is similar in structure and function to Escherichia coli PriB. | Primosome protein PriB is a single-stranded DNA-binding protein that serves as an accessory factor for PriA helicase-catalyzed origin-independent reinitiation of DNA replication in bacteria. A recent report describes the identification of a novel PriB protein in Klebsiella pneumoniae that is significantly shorter than most sequenced PriB homologs. The K. pneumoniae PriB protein is proposed to comprise 55 amino acid residues, in contrast to E. coli PriB which comprises 104 amino acid residues and ... | 2011 | 21931731 |
| global spread of carbapenemase-producing enterobacteriaceae. | carbapenemases increasingly have been reported in enterobacteriaceae in the past 10 years. klebsiella pneumoniae carbapenemases have been reported in the united states and then worldwide, with a marked endemicity at least in the united states and greece. metallo-enzymes (verona integron-encoded metallo-β-lactamase, imp) also have been reported worldwide, with a higher prevalence in southern europe and asia. carbapenemases of the oxacillinase-48 type have been identified mostly in mediterranean a ... | 2011 | 22000347 |
| The Prevalence of ESBLs Producing Klebsiella pneumoniae Isolates in Some Major Hospitals, Iran. | Aims of this study were to investigate on antibiotic resistance and molecular epidemiology of K.pneumoniae producing ESBLs isolates of respiratory tract infections in some major hospitals in Iran. K.pneumonaie were obtained of patients with RTI. K. pneumoniae producing ESBLs detected by screening, confirming and PCR methods. During the 12-month period, a total of one hundred and thirteen of K.pneumoniae were found from RTI in three cities in different region of Iran which Sixty seven strains (59 ... | 2011 | 21915229 |
| Necrotizing fasciitis following psoas muscle abscess caused by hypermucoviscous Klebsiella pneumoniae. | A 59-year-old Japanese diabetic woman was admitted to a small private hospital with general malaise, fever, and a 1-month history of low back pain. A computed tomography scan of the abdomen revealed left abdominal necrotizing fasciitis with suspected left psoas muscle abscess. She was transferred to Gunma University Hospital, received antibiotic therapy, and underwent debridement of the infected subcutaneous tissue, fascia, and necrotic left psoas muscle. She was transferred to the intensive car ... | 2011 | 22065090 |
| isolation and characterization of a klebsiella oxytoca strain for simultaneous azo-dye anaerobic reduction and bio-hydrogen production. | a facultative anaerobic bacteria strain gs-4-08, isolated from an anaerobic sequence batch reactor for synthetic dye wastewater treatment, was investigated for azo-dye decolorization. this bacterium was identified as a member of klebsiella oxytoca based on gram staining, morphology characterization and 16s rrna gene analysis. it exhibited a good capacity of simultaneous decolorization and hydrogen production in the presence of electron donor. the hydrogen production was less affected even at a h ... | 2011 | 22086069 |
| multidrug-resistant gram-negative bacterial infections after liver transplantation - spectrum and risk factors. | objectives: gram-negative bacilli infections, especially multidrug-resistant gram-negative bacilli infections, are the leading cause of high mortality after liver transplantation. this study sought to investigate the type of infection, infection rate, pathogenic spectrum, antibiotic-resistance profile, risk factors, and epidemiology of multidrug-resistant gram-negative bacterial infection. methods: a retrospective cohort study was conducted and data of 217 liver transplant patients receiving cad ... | 2011 | 22198738 |
| Role of antibiofilm-antimicrobial agents in controlling device-related infections. | Objectives: To assess the effects of N-acetylcysteine (NAC) on organism viability in planktonic and biofilm phases, biofilm thickness, and extracellular polysaccharide content. Methods: We performed time-kill curves and broth macrodilution assays of bacterial and fungal clinical isolates with varying concentrations of NAC. We also created in vitro bacterial biofilms, incubated them with NAC or control, and then stained with propidium iodide and FITC-labeled concanavalin A. We measured biofilm t ... | 2011 | 22094553 |
| dna, protein binding, cytotoxicity, cellular uptake and antibacterial activities of new palladium(ii) complexes of thiosemicarbazone ligands: effects of substitution on biological activity. | the coordination propensities of 4(n,n')-diethylaminosalicylaldehyde-4(n)-substituted thiosemicarbazones (h(2)l(1-4)) were investigated by reacting with an equimolar amount of [pdcl(2)(pph(3))(2)]. the new complexes were characterized by various spectroscopic techniques. the structure determination of the complexes [pd(deasal-tsc)(pph(3))] (1), [pd(deasal-mtsc)(pph(3))] (2) and [pd(deasal-etsc)(pph(3))] (3) by x-ray crystallography showed that ligands are coordinated in a dibasic tridentate ons ... | 2011 | 22051854 |
| identification of bacterial microflora in the midgut of the larvae and adult of wild caught anopheles stephensi: a step toward finding suitable paratransgenesis candidates. | to describe the midgut microbial diversity and to find the candidate bacteria for the genetic manipulation for the generation of paratransgenic anopheline mosquitoes refractory to transmission of malaria, the microbiota of wild larvae and adult anopheles stephensi mosquito midgut from southern iran was studied using a conventional cell-free culture technique and analysis of a 16s ribosomal rna (rrna) gene sequence library. forty species in 12 genera including seven gram-negative myroides, chryse ... | 2012 | 22074685 |
| Impact of adopting minimum inhibitory concentration as the determinant of susceptibility to cephalosporins and carbapenems in multi-drug resistant Enterobacteriaceae. | The Clinical and Laboratory Standards Institute has recommended that Enterobacteriaceae susceptibility to most cephalosporins and carbapenems be reported according to minimum inhibitory concentration (MIC) alone. We analyzed our record of multi-drug resistant Enterobacteriaceae to assess the impact of these changes. We compared susceptibilities of ceftriaxone-resistant Enterobacteriaceae when using the 2009 and new 2010 MIC standards. Vitek2® (BioMerieux), was used to assess the changes in susce ... | 2011 | 21912922 |
| Improved antimicrobial efficacy with nitric oxide releasing nanoparticle generated S-nitrosoglutathione. | Nitric oxide (NO) plays a vital role in mammalian host defense through a variety of mechanisms. In particular, NO can oxidize to form reactive nitrogen species or interact with protein thiols and metal centers, blocking essential microbial processes. S-nitrosoglutathione (GSNO), a potent NO donor formed by the interaction of NO with intracellular glutathione (GSH), is a major factor in this pathway and is considered one of the strongest naturally occurring nitrosating agent. We previously descri ... | 2011 | 21946032 |
| prevention of infections associated with combat-related extremity injuries. | during combat operations, extremities continue to be the most common sites of injury with associated high rates of infectious complications. overall, ∼ 15% of patients with extremity injuries develop osteomyelitis, and ∼ 17% of those infections relapse or recur. the bacteria infecting these wounds have included multidrug-resistant bacteria such as acinetobacter baumannii, pseudomonas aeruginosa, extended-spectrum β-lactamase-producing klebsiella species and escherichia coli, and methicillin-resi ... | 2011 | 21814090 |
| polyclonal antibody against conserved sequences of mce1a protein blocks mtb infection in macrophages. | the pathogenesis of mycobacterium tuberculosis is largely due to its ability to enter and survive within human macrophages. it is suggested that a specific protein namely mammalian cell entry protein is involved in the pathogenesis and the specific gene for this protein mce1a has been identified in several pathogenic organisms such as rickettsia, shigella, escherichia coli, helicobacter, streptomyces, klebsiella, vibrio, neisseria, rhodococcus, nocardioides, saccharopolyspora erthyrae, and pseud ... | 2011 | 22159737 |
| [susceptibility of klebsiella oxytoca to selected antibiotics]. | fifty two clinical isolates of k. oxytoca were included. all of analysed strains were isolated from wound swabs. the aim of this study was to evaluate mic value of amoxicillin with clavulanic acid, tigecycline and ciprofloxacin. the susceptibility to amoxicillin with clavulanic acid and tigecycline was tested by the etest. the susceptibility to ciprofloxacine was tested by the agar dilution method. among of analysed k. oxytoca strains 44 (84.6%) were susceptible to tigecycline, 27 (51.9%) to amo ... | 2011 | 22184898 |
| screening of antimicrobial activity of cistus ladanifer and arbutus unedo extracts. | in this work, the in vitro antimicrobial activity of different crude extracts obtained from cistus ladanifer l. and arbutus unedo l. was investigated. the ethanol, methanol and acetone/water extracts of cistus ladanifer and arbutus unedo were prepared using different extraction methods and their antimicrobial activities against reference strains, including three gram-positive, five gram-negative and three yeasts, and against clinical isolates of helicobacter pylori and methicillin-resistant stap ... | 2011 | 22077559 |
| [homology analysis of klebsiella pneumoniae isolated from clinic and hospital environments]. | | 2011 | 22172269 |
| Epidemiology and molecular characterisation of metallo-ß-lactamase-producing Enterobacteriaceae in a university hospital Intensive Care Unit in Greece. | The molecular epidemiology of VIM-producing Enterobacteriaceae isolated at the beginning of an epidemic in the Intensive Care Unit (ICU) of a university hospital in Athens, Greece, was studied. All Gram-negative organisms isolated from March 2004 to November 2005 positive for metallo-ß-lactamase (MBL) production were submitted to polymerase chain reaction (PCR) and sequencing, to repetitive sequence-based PCR (Rep-PCR) for molecular typing, and to S1 nuclease digestion for plasmid DNA characteri ... | 2011 | 21873034 |
| Comparative effectiveness of aminoglycosides, polymyxin B, and tigecycline for clearance of carbapenem-resistant Klebsiella pneumoniae from urine. | Carbapenem-resistant Klebsiella pneumoniae (CRKP) is an increasingly common cause of health care-associated urinary tract infections. Antimicrobials with in vitro activity against CRKP are typically limited to polymyxins, tigecycline, and often, aminoglycosides. We conducted a retrospective cohort study of cases of CRKP bacteriuria at New York-Presbyterian Hospital from January 2005 through June 2010 to compare microbiologic clearance rates based on the use of polymyxin B, tigecycline, or an ami ... | 2011 | 21968368 |
| [In vitro evaluation of bactericidal activity of an over-heated saturated dry atomized steam electro-medical device on inert contaminated surfaces]. | Surface disinfection together with cleaning practises and aseptic procedures are established measures for effective prevention of infectious diseases reducing infection risks. In this study, we evaluated the bactericidal effectiveness in vitro of the electro-medical device Sani System, an over-heated saturated dry-steam disinfection system, against predetermined bacterial load dried on inert surfaces. In particular we have tested different materials, representative of operating rooms furnishing ... | 2011 | 22026238 |
| emergence of klebsiella pneumoniae isolate co-producing ndm-1 with kpc-2 from india. | | 2012 | 21990048 |
| Gut microbiota of healthy and malnourished children in bangladesh. | Poor health and malnutrition in preschool children are longstanding problems in Bangladesh. Gut microbiota plays a tremendous role in nutrient absorption and determining the state of health. In this study, metagenomic tool was employed to assess the gut microbiota composition of healthy and malnourished children. DNA was extracted from fecal samples of seven healthy and seven malnourished children (n?=?14; age 2-3?years) were analyzed for the variable region of 16S rRNA genes by universal primer ... | 2011 | 22125551 |
| International Nosocomial Infection Control Consortium (INICC) report, data summary of 36 countries, for 2004-2009. | The results of a surveillance study conducted by the International Nosocomial Infection Control Consortium (INICC) from January 2004 through December 2009 in 422 intensive care units (ICUs) of 36 countries in Latin America, Asia, Africa, and Europe are reported. During the 6-year study period, using Centers for Disease Control and Prevention (CDC) National Healthcare Safety Network (NHSN; formerly the National Nosocomial Infection Surveillance system [NNIS]) definitions for device-associated hea ... | 2011 | 21908073 |
| Studies on antimicrobial activities of solvent extracts of different spices. | The antimicrobial activities of the ethyl acetate, acetone and methanol extract of 12 plant species were studied. The extract of Capsicum annuum (red pepper) (fruit) Zingiber officinale (ginger) (root), Cuminum cyminum (cumin), Alpinia ficinarum (galingale), Coriandrum sativum (coriander), Cinnamomun zeylanicum Nees (cinnamomun), Origanum onites L. (thyme), Folium sennae (senna), Eugenia caryophyllata (cloves), Flos tiliae (lime), Folium menthae crispae (peppermint) and Piper nigrum (blackpepper ... | 2011 | 21882663 |
| Biological activity of carbazole alkaloids and essential oil of Murraya koenigii against antibiotic resistant microbes and cancer cell lines. | A total of three carbazole alkaloids and essential oil from the leaves of Murraya koenigii (Rutaceae) were obtained and examined for their effects on the growth of five antibiotic resistant pathogenic bacteria and three tumor cell lines (MCF-7, P 388 and Hela). The structures of these carbazoles were elucidated based on spectroscopy data and compared with literature data, hence, were identified as mahanine (1), mahanimbicine (2) and mahanimbine (3). The chemical constituents of the essential oil ... | 2011 | 22105714 |
| synthesis and characterization of the antibacterial potential of zno nanoparticles against extended-spectrum β-lactamases-producing escherichia coli and klebsiella pneumoniae isolated from a tertiary care hospital of north india. | the reemergence of infectious diseases and the continuous development of multidrug resistance among a variety of disease-causing bacteria in clinical setting pose a serious threat to public health worldwide. extended-spectrum β-lactamases (esbls) that mediate resistance to third-generation cephalosporin are now observed all over the world in all species of enterobacteriaceae, especially escherichia coli and klebsiella pneumoniae. in this work, zno nanoparticles (nps) were synthesized by the sol- ... | 2011 | 22159886 |
| prevalence of extended-spectrum β-lactamase-producing escherichia coli and klebsiella pneumoniae in food-producing animals. | to evaluate the diversity of extended-spectrum β-lactamases (esbl) genes among food-producing animals, 48 isolates of esbl-producing escherichia coli isolates were obtained from rectal samples of broilers, layers, beef cattle and pigs, at the slaughterhouse level. esbl-carrying e. coli were isolated from 60.0% of individual broiler rectal samples, 5.9% of layers, 12.5% of beef cattle and 3% of pigs. one esbl-producing klebsiella pneumoniae was isolated from a broiler. the esbl-positive e. coli i ... | 2011 | 21979457 |
| molecular dissection of an outbreak of carbapenem-resistant enterobacteriaceae reveals intergenus kpc carbapenemase transmission through a promiscuous plasmid. | carbapenem-resistant enterobacteriaceae (cre) have emerged as major causes of health care-associated infections worldwide. this diverse collection of organisms with various resistance mechanisms is associated with increased lengths of hospitalization, costs of care, morbidity, and mortality. the global spread of cre has largely been attributed to dissemination of a dominant strain of klebsiella pneumoniae producing a serine β-lactamase, termed k. pneumoniae carbapenemase (kpc). here we report an ... | 2011 | 22045989 |
| molecular basis of ndm-1, a new antibiotic resistance determinant. | the new delhi metallo-β-lactamase (ndm-1) was first reported in 2009 in a swedish patient. a recent study reported that klebsiella pneumonia ndm-1 positive strain or escherichia coli ndm-1 positive strain was highly resistant to all antibiotics tested except tigecycline and colistin. these can no longer be relied on to treat infections and therefore, ndm-1 now becomes potentially a major global health threat.in this study, we performed modeling studies to obtain its 3d structure and ndm-1/antibi ... | 2011 | 21887283 |
| [the first experience of application of pcr techniques in real-time mode to diagnose bacteriemia during postoperational period in cardiosurgery patients]. | the results comparison is made between pcr polymerase chain reaction techniques in real-time mode and cultural techniques of analysis of blood samples in patients with suspicion of bacteriemia during early postoperational period. from september to december 2009 43 blood samples from 37 adult patients aged 59+9.2 years were analyzed on suspicion of bacteriemia. the blood samples for pcr analysis (septifast technique roche diagnostics, switzerland) were taken parallel to the inoculation. among 43 ... | 2011 | 22164420 |
| Outcomes and characteristics of ertapenem-nonsusceptible Klebsiella pneumoniae bacteremia at a university hospital in Northern Taiwan: A matched case-control study. | BACKGROUND AND PURPOSE: Carbapenem-resistant Klebsiella pneumoniae is an emerging problem worldwide. The object of this study was to investigate the risk factors, characteristics and outcomes of ertapenem-nonsusceptible K pneumoniae (ENSKp) bacteremia. METHODS: We conducted a 1:2 ratio matched case-control study. The controls were randomly selected among patients with ertapenem-susceptible K pneumoniae (ESKp) bacteremia and were matched with ENSKp cases for bacteremia. RESULTS: Seventy-five pati ... | 2011 | 22154994 |
| urinary pathogens and drug susceptibility patterns of urinary tract infections among antenatal clinic attendees in ibadan, nigeria. | aim: to determine the bacterial agents involved in urinary tract infections in pregnant women and their antibiotic susceptibility patterns in ibadan, nigeria. methods: all consenting subjects who attended antenatal clinics of the university college hospital and adeoyo maternity hospital, ibadan, nigeria, from 1 april 2007 and 30 march 2009 were interviewed to obtain demographic and pregnancy health data. mid-stream urine samples obtained were processed by standard methods. confirmed bacterial ... | 2011 | 21917070 |
| Exploring the DNA binding mode of transition metal based biologically active compounds. | Few novel 4-aminoantipyrine derived Schiff bases and their metal complexes were synthesized and characterized. Their structural features and other properties were deduced from the elemental analysis, magnetic susceptibility and molar conductivity as well as from mass, IR, UV-vis, (1)H NMR and EPR spectral studies. The binding of the complexes with CT-DNA was analyzed by electronic absorption spectroscopy, viscosity measurement, and cyclic voltammetry. The interaction of the metal complexes with ... | 2012 | 22020164 |
| Microbiology of the chronic suppurative otitis media. | The aim of the study was to determine aetiological agents of chronic suppurative inflammation of the middle ear and their susceptibility to antibiotics, which could lead to better therapeutic decisions and consequently avoidance of appearance of resistance to specific antibiotics. Most frequently isolated agents were Staphylococcus aureus (30.6%), Pseudomonas aeruginosa (22.4%), Klebsiella spp. (10.6%) and Proteus spp. (7.1%). None of the isolates were resistant to ciprofloxacin. High sensitivit ... | 2011 | 21849954 |
| Containment of an outbreak of KPC-3-producing Klebsiella pneumoniae in Italy. | From March 2009 to May 2009, 24 carbapenem-resistant Klebsiella pneumoniae isolates were recovered from 16 patients hospitalized in an Italian intensive care unit (ICU). All isolates contained KPC-3 carbapenemase and belonged to a single pulsed-field gel electrophoresis (PFGE) clone of multilocus sequence type 258 (designated as ST258). A multimodal infection control program was put into effect, and the spread of the KPC-3-producing K. pneumoniae clone was ultimately controlled without closing t ... | 2011 | 21900525 |
| Intravenous device associated blood stream staphylococcal infection in paediatric patients. | Intravenous device (IVD) associated nosocomial blood stream infections due to staphylococci are major cause of morbidity and mortality. The present study was carried out to assess the frequency of staphylococcal IVD associated infections in a paediatric ward of a tertiary case hospital. Prevalence of resistance to commonly used antimicrobials in hospital acquired staphylococcal isolates was also tested. | 2011 | 21911972 |
| target highlights in casp9: experimental target structures for the critical assessment of techniques for protein structure prediction. | one goal of the casp community wide experiment on the critical assessment of techniques for protein structure prediction is to identify the current state of the art in protein structure prediction and modeling. a fundamental principle of casp is blind prediction on a set of relevant protein targets, that is, the participating computational methods are tested on a common set of experimental target proteins, for which the experimental structures are not known at the time of modeling. therefore, th ... | 2011 | 22020785 |
| activity of tigecycline and comparators against skin and skin structure pathogens: global results of the tigecycline evaluation and surveillance trial, 2004-2009. | this analysis from the global tigecycline evaluation and surveillance trial (t.e.s.t.) reports on 24 784 isolates collected from integumentary culture sources between 2004 and 2009. | 2011 | 22104303 |
| clinical characteristics of bacteraemia caused by extended-spectrum β-lactamase-producing enterobacteriaceae in the era of ctx-m-type and kpc-type β-lactamases. | clin microbiol infect abstract: a multicentre, case-control study was conducted to assess risk factors and patient outcomes of bacteraemia caused by enterobacteriaceae producing extended-spectrum β-lactamases (esbls) and klebsiella pneumoniae carbapenemases (kpcs). one hundred and five and 20 patients with bacteraemia caused by esbl-producing and kpc-producing organisms were matched to controls who had bacteraemia caused by non-esbl/kpc-producing organisms, respectively. independent risk factors ... | 2011 | 21951551 |
| Evaluation of doripenem utilization and susceptibilities at a large urban hospital. | Background Bacterial resistance presents a constant challenge in the treatment of hospitalized patients, particularly with Gram-negative infections. Carbapenems have an important role in the treatment of resistant nosocomial organisms. Doripenem, a recently approved carbapenem, has shown efficacy in clinical trials, but there is little published data on utilization in a general patient population. Objective The clinical utilization of doripenem in a general adult inpatient population was evaluat ... | 2011 | 21984226 |
| prevalence and risk factors for unsuspected spontaneous ascitic fluid infection in cirrhotics undergoing therapeutic paracentesis in an outpatient clinic. | spontaneous bacterial peritonitis (sbp) has been typically described in hospitalized patients. there are little data on ascitic fluid infection in asymptomatic outpatients. the present study was aimed at determining the prevalence and risk factors for asymptomatic ascitic fluid infection among patients with liver cirrhosis attending an outpatient clinic. | 2011 | 21956818 |
| Failure of polymyxin B and fosfomycin combination to eradicate extensively antibiotic Klebsiella pneumoniae from the urine despite in-vitro activity. | | 2011 | 22057591 |
| in-vitro activity of three brands of ceftriaxone against different clinical isolates. | ceftriaxone is an extended spectrum cephalosporin that has been used for decades for combating infections caused by wide array of pathogens and prescription of antibiotic is in favor of specific brands without realizing the potency of the brand. the in-vitro activity of three brands of ceftriaxone and various antibiotics against clinical isolates is studied. | 2010 | 22049828 |
| Randomized clinical trial to evaluate the efficacy of a 5-day ceftiofur hydrochloride intramammary treatment on nonsevere gram-negative clinical mastitis. | The objective of this study was to evaluate the efficacy of intramammary treatment with ceftiofur hydrochloride of nonsevere, clinical coliform mastitis. One hundred four cases on 5 farms met the enrollment criteria for the study. Escherichia coli was the most common coliform species identified in milk samples from cows with mild to moderate clinical mastitis, followed by Klebsiella spp. and Enterobacter spp. At enrollment, a milk sample from the affected quarter was taken and used for on-farm c ... | 2011 | 22118109 |
| genetic features of blandm-1-positive enterobacteriaceae. | genetic features associated with the bla(ndm-1) gene were investigated in 6 escherichia coli, 7 klebsiella pneumoniae, 1 citrobacter freundii, 1 proteus mirabilis, and 1 providencia stuartii isolate of worldwide origin. clonal diversity was observed for both e. coli and k. pneumoniae. the bla(ndm-1) gene was carried by different plasmid types (inca/c, incf, incl/m, or untypeable) and was likely chromosome borne in two isolates. the bla(ndm-1) plasmids coharbored a variety of resistance determina ... | 2011 | 21859933 |
| structure of plantaricin locus of lactobacillus plantarum 8p-a3. | lactobacillus plantarum 8p-a3 is a strain which is well known on the russian pharmaceutical market and it is included in several probiotic products. the strain has been widely used since 1973 but the mechanisms of its antibacterial activity were unknown. l. plantarum 8p-a3 expressed high antagonistic activity against the wide range of bacterial pathogens including streptococcus agalactiae, streptococcus pyogenes, staphylococcus aureus, escherichia coli, pseudomonas aeruginosa and klebsiella pneu ... | 2011 | 22146685 |
| evolution to carbapenem-hydrolyzing activity in noncarbapenemase class d β-lactamase oxa-10 by rational protein design. | class d β-lactamases with carbapenemase activity are emerging as carbapenem-resistance determinants in gram-negative bacterial pathogens, mostly acinetobacter baumannii and klebsiella pneumoniae. carbapenemase activity is an unusual feature among class d β-lactamases, and the structural elements responsible for this activity remain unclear. based on structural and molecular dynamics data, we previously hypothesized a potential role of the residues located in the short-loop connecting strands β5 ... | 2011 | 22042844 |
| the microbial flora associated with oral carcinomas. | changes in the microbial flora on the oral mucosa after cancerous alteration may lead to both local and systemic infections. in this study, we assessed the microbial flora associated with the surfaces of oral squamous cell carcinoma. a comparative evaluation of these microbial contents was made with that of the contralateral healthy mucosa and control (healthy) mucosa. we also assessed the microbial flora from the saliva culture in subjects with oral squamous cell carcinoma and healthy controls. | 2011 | 21909494 |
| Molecular Epidemiology of Ciprofloxacin-Resistant Extended-Spectrum ß-Lactamase-Producing Klebsiella pneumoniae in Taiwan. | Fluoroquinolone resistance in extended-spectrum ß-lactamases (ESBL)-producing isolates results in very few antimicrobial treatment options. In Taiwan's Surveillance of Antimicrobial Resistance (TSAR) III program, 124 (52.8%) cases of ESBL-producing Klebsiella pneumoniae (ESBL-KP) were resistant to ciprofloxacin. The prevalence of plasmid-mediated quinolone resistance (PMQR) determinants and chromosomal quinolone resistance-determining regions (QRDR) of gyrA and parC genes among ESBL-KP isolates ... | 2011 | 22022870 |
| Pharmacokinetic and pharmacodynamic evaluation of tigecycline. | INTRODUCTION: As the spread of multidrug-resistant (MDR) and extensive drug-resistant (XDR) organisms constitutes a real threat for patients, new antimicrobials are needed. Tigecycline, the first-in-class glycylcycline, possesses an extended spectrum of antimicrobial activity including MDR and XDR organisms, which holds promise as a treatment option beyond currently approved indications and deserves expanded evaluation of its pharmacokinetics/pharmacodynamics (PK/PD). AREAS COVERED: This review ... | 2011 | 21958044 |
| Minor pseudopilin self-assembly primes type II secretion pseudopilus elongation. | In Gram-negative bacteria, type II secretion systems (T2SS) assemble inner membrane proteins of the major pseudopilin PulG (GspG) family into periplasmic filaments, which could drive protein secretion in a piston-like manner. Three minor pseudopilins PulI, PulJ and PulK are essential for protein secretion in the Klebsiella oxytoca T2SS, but their molecular function is unknown. Here, we demonstrate that together these proteins prime pseudopilus assembly, without actively controlling its length or ... | 2011 | 22157749 |
| [phenotypic detection of carbapenemase associated with extended-spectrum beta-lactamase in klebsiella pneumoniae]. | | 2011 | 22154523 |
| Effects of arsenite stress on growth and proteome of Klebsiella pneumoniae. | In the present study an arsenite, As(III), tolerating bacterium, MR4, was isolated from Mulla River Pune, India, capable of reducing arsenate to arsenite and identified as Klebsiella pneumoniae (HQ857583). Comparative proteomic analysis using two-dimensional gel electrophoresis (2-DGE) and matrix assisted laser desorption ionization-time of flight-time of flight (MALDI-TOF/TOF) was used to monitor the proteins undergoing changes in expression levels under 2.5mM As(III) stress. The 2-DGE proteome ... | 2011 | 22209886 |
| the rising problem of antimicrobial resistance in the intensive care unit. | abstract: mainly due to its extremely vulnerable population of critically ill patients, and the high use of (invasive) procedures, the intensive care unit (icu) is the epicenter of infections. these infections are associated with an important rise in morbidity, mortality, and healthcare costs. the additional problem of multidrug-resistant pathogens boosts the adverse impact of infections in icus. several factors influence the rapid spread of multidrug-resistant pathogens in the icu, e.g., new mu ... | 2011 | 22112929 |
| prevalence of plasmid-mediated quinolone resistance and its association with extended-spectrum beta-lactamase and ampc beta-lactamase in enterobacteriaceae. | we investigated the prevalence of plasmid-mediated quinolone resistance and its association with extended-spectrum beta-lactamase (esbl) and ampc beta-lactamase in enterobacteriaceae. | 2011 | 22016679 |
| in vitro susceptibility test of different clinical isolates against ceftriaxone. | because of the prevailing penicillin resistance in microorganisms, broad spectrum cephalosporins are used empirically specially in developing countries. the aim of this study is to determine the susceptibility pattern of different gram positive and gram negative pathogens against third generation cephalosporin-ceftriaxone to explore the existing effectiveness of this antibiotic. | 2010 | 22043337 |
| [investigation of plasmid-mediated quinolone resistance in pseudomonas aeruginosa strains isolated from cystic fibrosis patients]. | pseudomonas aeruginosa which is widely found in the environment, may lead to serious nosocomial infections. due to its intrinsic resistance to many antibacterial agents, treatment of p.aeruginosa infections usually present difficulty. quinolones, especially ciprofloxacin, are crutial antibiotics for the treatment of p.aeruginosa infections. however resistance developing to quinolones may become an important problem. resistance to quinolones is often a result of chromosomal mutations and by the e ... | 2011 | 22090290 |
| In vitro activity of avibactam (NXL104) in combination with ß-lactams against Gram-negative bacteria, including OXA-48 ß-lactamase-producing Klebsiella pneumoniae. | The objective of this study was to investigate the in vitro antibacterial activity of avibactam (formerly NXL104) in combination with imipenem, cefepime or ceftazidime against Gram-negative bacteria. Bacterial isolates included: Pseudomonas aeruginosa harbouring PER-1 ß-lactamase (n=14); Acinetobacter baumannii harbouring PER-1, OXA-51 and OXA-58 (n=20); carbapenem-non-susceptible Klebsiella pneumoniae (n=25) and Escherichia coli (n=1) harbouring OXA-48; carbapenem-non-susceptible E. coli (n=1) ... | 2012 | 22041508 |
| effects of copper nanoparticle exposure on host defense in a murine pulmonary infection model. | human exposure to nanoparticles (nps) and environmental bacteria can occur simultaneously. nps induce inflammatory responses and oxidative stress but may also have immune-suppressive effects, impairing macrophage function and altering epithelial barrier functions. the purpose of this study was to assess the potential pulmonary effects of inhalation and instillation exposure to copper (cu) nps using a model of lung inflammation and host defense. | 2011 | 21943386 |