| Community-onset bacteraemia caused by fluoroquinolone-resistant Klebsiella pneumoniae: clinical epidemiology and risk factors. | | 2011 | 22100279 |
| [the changing epidemiology of extended spectrum β-lactamase-producing klebsiella pneumoniae]. | in the last two decades, klebsiella pneumoniae demonstrated some characteristics of acquisition of plasmids coding extended spectrum β-lactamases (esbl). the review data showed an increase in worldwide prevalence of esbl and a temporal shift in the prevalence of esbl types in k. pneumoniae during this last decade. ctx-m-15 seems to be the predominant esbl type in k. pneumoniae in some parts of the world. the dissemination of several nosocomial ctx-m-15-producing k. pneumoniae clones was reported ... | 2011 | 22008131 |
| comparison of plasmid-mediated quinolone resistance and extended-spectrum β-lactamases in third-generation cephalosporin-resistant enterobacteriaceae from four irish hospitals. | in this study, the frequency of extended-spectrum β-lactamases (esbl) and plasmid-mediated quinolone resistance (pmqr) mechanisms were investigated in 206 clinical isolates of third-generation cephalosporin (3gc)-resistant enterobacteriaceae in four hospitals in the republic of ireland. bla(ctx-m-15) was the predominant esbl gene. of these 3gc resistant isolates, 54 % were also resistant to ciprofloxacin. investigation of the pmqr mechanisms revealed that the aac(6')ib-cr gene predominated in fl ... | 2012 | 21903826 |
| Enhancement of pH stability and activity of glycerol dehydratase from Klebsiella pneumoniae by rational design. | Glycerol dehydratase (GDHt) is a key and rate-limiting enzyme in the pathway of 1,3-propanediol (1,3-PD) synthesis. The improvement of GDHt's stability and enzymatic activity is desirable for the biosynthesis of 1,3-PD. The gldABC gene encoding GDHt of Klebsiella pneumoniae was cloned and expressed in Escherichia coli XL10-Gold, and the mutation sites of GDHt were obtained through prediction by PoPMuSiC program. Consequently, two mutants (KpG60 and KpG525) were developed by rational design throu ... | 2011 | 22042303 |
| a prospective study of catheter-related complications in hpn patients. | background & aims: central venous access device (cvad)-related complications such as catheter-related sepsis, occlusion and breakage contribute to both mortality and morbidity in home parenteral nutrition (hpn) patients. prospectively collected data in these patients are scarce. methods: data on all cvad-related complications in four tertiary referral centres in australia and new zealand were prospectively collected between 01/01/2009 and 31/12/2009 together with costs of each episode that requi ... | 2011 | 21974812 |
| clinical characteristics and outcomes of patients with extended-spectrum β-lactamase-producing bacteremias in the emergency department. | extended-spectrum β-lactamase (esbl)-producing bacteria have been spreading from hospitals to communities. despite this, there are limited emergency department (ed) patient-based studies about these bacteremias. a retrospective matched case-control study with a ratio of 1:3 was conducted at a university hospital. the case group consisted of patients aged >16 years with esbl-producing bacteremias in the ed. patients matched for age and sex with non-esbl-producing bacteremias were sampled as the c ... | 2011 | 22033790 |
| Molecular characterization of newly emerged blaKPC-2-producing Klebsiella pneumoniae in Singapore. | In Asia, bla(KPC) detectionhas been limited to East Asia and not yet seen in Southeast Asia. We report four bla(KPC-2)-containing Klebsiella pneumoniae isolates from two different hospitals in Singapore. All isolates belonged to strain type 11 (ST11) and were indistinguishable by pulse-field gel electrophoresis (PFGE). bla(KPC-2) was located on non-conjugative plasmids and flanked by mobile genetic structures comprising of a partial Tn4401 and Tn3-based transposon which previously have only been ... | 2011 | 22116160 |
| [acute appendicitis due to both klebsiella pneumoniae and serotype 35b streptococcus pneumoniae, an emergent serotype]. | streptococcus pneumoniae has been rarely considered as an infectious agent in appendicitis. we report a case of a 47-year-old woman with acute appendicitis caused both by serotype 35b s. pneumoniae and klebsiella pneumoniae. the pathway of the appendix colonisation remains unclear. it could be explain by direct infection via mucosal translocation or by hematogenous spread. pneumococcal appendicitis could progress to perforation more frequently. the use of intraoperative samples for management of ... | 2011 | 21896418 |
| Effective cohorting and "superisolation" in a single intensive care unit in response to an outbreak of diverse multi-drug-resistant organisms. | Cohorting patients in dedicated hospital wards or wings during infection outbreaks reduces transmission of organisms, yet frequently, this may not be feasible because of inadequate capacity, especially in the intensive care unit (ICU). We hypothesized that cohorting isolation patients in one geographic location in a single ICU and using enhanced isolation procedures ("superisolation") can prevent the further spread of highly multi-drug-resistant organisms (MDRO). | 2011 | 21936667 |
| klebsiella pneumoniae type 3 fimbriae agglutinate yeast in a mannose resistant manner. | the ability of bacterial pathogens to express different fimbrial adhesins plays a significant role in virulence. thus, specific detection of fimbrial expression is an important task in virulence characterization and epidemiological studies. most clinical klebsiella pneumoniae isolates express type 1 and type 3 fimbriae characterized by mediating mannose sensitive agglutination of yeast cells, and agglutination of tannic acid treated ox red blood cells (rbcs), respectively. we have observed that ... | 2011 | 22016558 |
| control of clinical pathogens by the haemolymph of paratelphusa hydrodromous, a freshwater crab. | in the present study, effort has been made to find the antimicrobial activity of haemolymph collected from freshwater crab, paratelphusa hydrodromous. the haemolymph collected was tested for antimicrobial assay by disc diffusion method against clinical pathogens. five bacterial species, namely, escherichia coli, klebsiella pneumonia, proteus mirabilis, pseudomonas aeruginosa, staphylococcus aureus, and five fungal strains, namely and aspergillus flavus, aspergillus fumigatus, aspergillus niger, ... | 2011 | 22084719 |
| Characterization of anticancer, antimicrobial, antioxidant properties and chemical compositions of Peperomia pellucida leaf extract. | Peperomia pellucida leaf extract was characterized for its anticancer, antimicrobial, antioxidant activities, and chemical compositions. Anticancer activity of P. pellucida leaf extract was determined through Colorimetric MTT (tetrazolium) assay against human breast adenocarcinoma (MCF-7) cell line and the antimicrobial property of the plant extract was revealed by using two-fold broth micro-dilution method against 10 bacterial isolates. Antioxidant activity of the plant extract was then charact ... | 2011 | 22071643 |
| Emergence of New Delhi metallo-beta-lactamase (NDM-1) and Klebsiella pneumoniae carbapenemase (KPC-2) in South Africa. | This report documents emergence of NDM-1 and KPC-2 carbapenemases in K.pneumoniae and E. cloacae in South Africa. NDM-1 producers have not been described in South Africa and this is the first instance that KPC producers have been identified in Africa. The two patients infected with these carbapenemase-producing bacteria demised. | 2011 | 22116157 |
| isolation of a klebsiella pneumoniae isolate of sequence type 258 producing kpc-2 carbapenemase in korea. | carbapenem-resistant klebsiella pneumoniae isolates producing k. pneumoniae carbapenemases (kpc) were first reported in the usa in 2001, and since then, this infection has been reported in europe, israel, south america, and china. in korea, the first kpc-2-producing k. pneumoniae sequence type (st) 11 strain was detected in 2010. we report the case of a patient with a urinary tract infection caused by kpc-2-producing k. pneumoniae. this is the second report of a kpc-2-producing k. pneumoniae inf ... | 2011 | 22016687 |
| Antibacterial activity of some Indian Ayurvedic preparations against enteric bacterial pathogens. | In Ayurveda, various herbal preparations are clinically used to prevent or cure infectious diseases. Herbal preparations such as Triphala churna, Hareetaki churna, Dashmula churna, Manjistadi churna, Sukhsarak churna, Ajmodadi churna, Shivkshar pachan churna, Mahasudarshan churna, Swadist Virechan churna and Pipramool churna were investigated by preparing their organic solvent extract for antibacterial potential against enteric bacterial pathogens such as Escherichia coli, Staphylococcus aureus, ... | 2011 | 22171288 |
| pharmacodynamics of β-lactamase inhibition by nxl104 in combination with ceftaroline: examining organisms with multiple types of β-lactamases. | new broad-spectrum β-lactamases such as kpc enzymes and ctx-m-15 enzymes threaten to markedly reduce the utility of our armamentarium of β-lactam agents, even our most potent drugs, such as carbapenems. nxl104 is a broad-spectrum non-β-lactam β-lactamase inhibitor. in this evaluation, we examined organisms carrying defined β-lactamases and identified doses and schedules of nxl104 in combination with the new cephalosporin ceftaroline, which would maintain good bacterial cell kill and suppress res ... | 2012 | 22024819 |
| Genetic Features of the Widespread Plasmid Coding for the Carbapenemase OXA-48. | Complete sequencing of plasmid pOXA-48a carrying the bla(OXA-48) gene from a Klebsiella pneumoniae isolate was performed. Its backbone corresponded to that of an IncL/M-type plasmid, in which the bla(OXA-48) gene had been integrated through the acquisition of the Tn1999 composite transposon without any other antibiotic resistance gene. Molecular epidemiology using a collection of international OXA-48 producers revealed the wide diffusion of pOXA-48a or closely related plasmids. | 2012 | 22083465 |
| th17 memory cells aren't fooled by sugar-coating. | klebsiella bacteria evade humoral immunity by altering their polysaccharide capsular antigens. in this issue of immunity, chen et al. (2011) propose a new vaccination strategy, demonstrating that th17 memory cells can provide cross-protection against multiple serotypes of klebsiella pneumoniae. | 2011 | 22195742 |
| Outbreak of NDM-1-producing Enterobacteriaceae in northern Italy, July to August 2011. | | 2011 | 22152705 |
| Antimicrobial activity of ceftobiprole against gram-negative and gram-positive pathogens: results from INVITA-A-CEFTO Brazilian study. | Ceftobiprole is a broad-spectrum cephalosporin with potent activity against staphylococci, including those resistant to oxacillin, as well as against most gram-negative bacilli including Pseudomonas aeruginosa. In this study, the in vitro activity of ceftobiprole and comparator agents was tested against bacterial isolates recently collected from Brazilian private hospitals. A total of 336 unique bacterial isolates were collected from hospitalized patients between February 2008 and August 2009. E ... | 2011 | 21861004 |
| Emergence of NDM-1-producing Klebsiella pneumoniae in Morocco. | To analyse the mechanisms responsible for multidrug resistance in three carbapenem-resistant Klebsiella pneumoniae isolates recovered from two hospitalized patients and an outpatient from the same hospital in Rabat, Morocco. | 2011 | 21930570 |
| Diversity of acquired ß-lactamases amongst Klebsiella pneumoniae in Greek hospitals. | | 2011 | 22104281 |
| Transfer of an Escherichia coli ST131 multiresistance cassette has created a Klebsiella pneumoniae-specific plasmid associated with a major nosocomial outbreak. | Objectives To characterize the complete sequence, horizontal spread and stability of the CTX-M-15-encoding multiresistance plasmid of a Klebsiella pneumoniae strain involved in a large nosocomial outbreak. Methods The 220 kbp plasmid pUUH239.2 was completely sequenced using 454 technology. The conjugational host range, conjugation frequencies, plasmid stability and fitness cost of plasmid carriage were studied in vitro. Conjugational spread during the outbreak was assessed retrospectively by mu ... | 2012 | 21990049 |
| a case of gas-forming liver abscess with diabetes mellitus. | a 43-year-old man was admitted to our hospital with right hypochondriac and epigastric pain. an abdominal radiograph showed a large niveau in the right subphrenic space. an abdominal ct scan demonstrated a large liver abscess (diameter, 13 cm) with gas formation. klebsiella pneumoniae cells were isolated from the abscess, and the patient was treated with antibiotics and percutaneous drainage. it is very important to treat gas-forming liver abscess immediately, because subsequent bacteremia and s ... | 2011 | 22001459 |
| ampicillin versus penicillin in the empiric therapy of extremely low-birthweight neonates at risk of early onset sepsis. | background: there are no comparative data on the impact of different empiric antibiotic regimens on early bowel colonization as well as on clinical efficacy in extremely low-birthweight (elbw) neonates at risk of early onset sepsis (eos). methods: a subgroup analysis was carried out of elbw neonates recruited into a two-center, prospective, cluster randomized study comparing ampicillin and penicillin both combined with gentamicin, within the first 72 h of life. a composite primary end-point (n ... | 2011 | 21895866 |
| Multi-drug resistant gram negative bacilli causing early neonatal sepsis in India. | ObjectiveTo study the organisms causing early and late onset neonatal sepsis, with special reference to multi-drug resistant gram negative bacilli, at two neonatal units (one urban, one rural) in India.MethodsProspective surveillance study.ResultsThere were 159 episodes of sepsis (81 urban and 77 rural) affecting 158 babies. Gram negative bacilli caused 117 infections (68%) and predominated at both centres in both early and late sepsis. Klebsiella pneumoniae was the commonest organism, causing 6 ... | 2011 | 22155619 |
| Childhood suppurative otitis media in Abakaliki: isolated microbes and in vitro antibiotic sensitivity pattern. | Suppurative otitis media (SOM) is the most common pediatric problem seen by otolaryngologists in Nigeria. Devising simple and effective ways of treating pediatric patients with suppurating ears, especially in situations without a specialist care, will help prevent chronicity. Our experience with som at the ebonyi state university teaching hospital (ebsuth), abakaliki, is reviewed in this study. it may serve as a guide in patient care. | 2011 | 21860131 |
| contact-lens-related corneal ulcer caused by klebsiella pneumoniae. | | 2011 | 21915511 |
| [Uncomplicated lower urinary tract infections in females--clinical aspects, aetiology and antimicrobial resistance epidemiology. Results of the ARESC (Antimicrobial Resistance Epidemiological Survey on Cystitis) study in Poland and their implications for empiric therapy]. | The Polish results of the international ARESC study are reported concerning clinical aspects, epidemiology, and antimicrobial susceptibility of uropathogens. | 2011 | 21913487 |
| infection with klebsiella pneumoniae carbapenemase (kpc)-producing k. pneumoniae in solid organ transplantation. | klebsiella pneumoniae carbapenemase (kpc)-producing k. pneumoniae is spreading globally and represents a challenge in infection control and treatment. solid organ transplant (sot) recipients are especially at risk for infection by multidrug-resistant bacteria, and little is known about infection with kpc-producing organisms in this setting. the aim of this study was to describe the clinical and microbiologic aspects of kpc-producing k. pneumoniae infections in sot recipients. a kpc-2-producing k ... | 2011 | 22093103 |
| Fluorinated s-triazinyl piperazines as antimicrobial agents. | A series of 1,3,5-triazine derivatives that contain 4-amino-2-trifluoromethyl-benzonitrile, 8-hydroxyquinoline, and different piperazines as substituents at the carbon atoms of the triazine ring have been synthesized by a simple and efficient synthetic protocol. The chemical structures of the compounds were elucidated with the aid of IR, 1H NMR and 13C NMR spectroscopy, and elemental analysis. The antimicrobial activity of the compounds was tested against seven bacteria (Staphylococcus aureus MT ... | 2011 | 21950158 |
| Two cases of monomicrobial intraabdominal abscesses due to KPC--3 Klebsiella pneumoniae ST258 clone. | Knowledge of the etiology of pyogenic liver and pancreatic abscesses is an important factor in determining the success of combined surgical and antibiotic treatment. Literature shows geographical variations in the prevalence and distribution of causative organisms, and the spread of Klebsiella pneumoniae carbapenemase-producing bacteria is an emerging cause of abdominal infections. | 2011 | 21961811 |
| frequency of extended spectrum beta lactamase producing enterobacteriaceae among urinary pathogen isolates. | objective: to determine the frequency of extended-spectrum beta lactamase (esbl) producing enterobacteriaceae in urinary isolates. study design: observational study. place and duration of study: ziauddin university hospital, karachi, from february to october 2008. methodology: all members of enterobacteriaceae isolated from urinary samples of in-patients were included and identified using standard biochemical tests. urinary samples from out-patients were excluded. detection of esbl was carried o ... | 2011 | 22166694 |
| relative frequency of health care-associated pathogens by infection site at a university hospital from 1980 to 2008. | background: we describe the relative frequency of health care-associated pathogens by infection site over 29 years using hospital-wide surveillance data from a large academic hospital. methods: comprehensive hospital-wide surveillance was provided by trained infection preventionists using centers for disease control and prevention definitions. five 5-year blocks and one 4-year block were created for each site: bloodstream infections (bsi), urinary tract infections (uti), respiratory tract infect ... | 2011 | 21943832 |
| klebsiella spp as a 1, 3-propanediol producer - the metabolic engineering approach. | klebsiella spp are one of the best natural producers of 1,3-propanediol (1,3-pd). however, their usage in the biotechnological production of the diol is limited, since the species belong to the second hazard group. nevertheless, multiple advantageous traits of klebsiella spp justify the international effort devoted to develop a biotechnological process of 1,3-pd production with these microorganisms. apart from the process engineering approach aiming at improvement of 1,3-pd production by klebsie ... | 2011 | 21995522 |
| clinical pharmacokinetics of meropenem and biapenem in bile and dosing considerations for biliary tract infections based on site-specific pharmacodynamic target attainment. | the present study investigated the pharmacokinetics of meropenem and biapenem in bile and estimated their pharmacodynamic target attainment at the site. meropenem (0.5 g) or biapenem (0.3 g) was administered to surgery patients (n = 8 for each drug). venous blood samples and hepatobiliary tract bile samples were obtained at the end of infusion (0.5 h) and for up to 5 h thereafter. drug concentrations in plasma and bile were analyzed pharmacokinetically and used for a monte carlo simulation to pr ... | 2011 | 21947393 |
| characterization of a dha-1-producing klebsiella pneumoniae strain involved in an outbreak and role of the ampr regulator in virulence. | a clonal strain of klebsiella pneumoniae producing the plasmid-encoded cephalosporinase dha-1 was isolated from four patients admitted to the teaching hospital of clermont-ferrand, france, in 2006. it was responsible for severe infections in three of the patients; the fourth was colonized only in the gastrointestinal tract. the strain had at least two plasmids encoding resistance to antibiotics (quinolones, aminoglycosides, chloramphenicol, sulfonamides, and trimethoprim), as shown by disk diffu ... | 2012 | 21986829 |
| implementation and outcomes of a hospital-wide computerised antimicrobial stewardship programme in a large medical centre in taiwan. | antibiotic stewardship is important to address the problem of antimicrobial resistance, but a practical and sustainable strategy to provide stewardship in a large hospital setting is lacking. we developed a hospital-wide computerised antimicrobial approval system (hcaas) to guide the use of antimicrobial agents in late 2004 in a 3500-bed medical centre in taiwan. the objective of this study was to evaluate the impacts of hcaas on the hospital from 2003 to 2009. following hcaas deployment, the gr ... | 2011 | 21982143 |
| chromate-resistance genes in plasmids from antibiotic-resistant nosocomial enterobacterial isolates. | the presence of chromate-resistance genes in enterobacteria was evaluated in a collection of 109 antibiotic-resistant nosocomial isolates from nine major cities in méxico. results were compared with the presence of mercury-resistance genes. susceptibility tests showed that 21% of the isolates were resistant to chromate (cr(r) ), whereas 36% were resistant to mercury (hg(r) ). cr(r) levels were high in klebsiella pneumoniae (61%), low in enterobacter cloacae (12%) and escherichia coli (4%), and ... | 2011 | 22136744 |
| prospective study of bacteremia rate after elective band ligation and sclerotherapy with cyanoacrylate for esophageal varices in patients with advanced liver disease. | band ligation (bl) is the most appropriate endoscopic treatment for acute bleeding or prophylaxis of esophageal variceal bleeding. sclerotherapy with n-butyl-2-cyanoacrylate (cy) can be an alternative for patients with advanced liver disease. bacteremia is an infrequent complication after bl while the bacteremia rate following treatment with cy for esophageal varices remains unknown. | 2011 | 22147129 |
| [revealing the genetic determinants of pks-pathogenicity island in clinical strains of enterobacteria]. | detection by pcr the frequency of clbb, clbn, clba h clbq genes of pks-pathogenicity island in clinical strains ofenterobacteria. | 2011 | 22145340 |
| Emergence and rapid regional spread of Klebsiella pneumoniae carbapenemase-producing Enterobacteriaceae. | Exposure network analysis and molecular epidemiologic methods were used to analyze the emergence and regional spread of Klebsiella pneumoniae carbapenemase-producing Enterobacteriaceae over a 1-year period. Although 40 patients and 26 health care facilities were affected, 1 long-term acute care hospital played a critical role in the convergence of patients at high risk, amplification by cross-infection, and dissemination of these multidrug-resistant bacteria. | 2011 | 21865189 |
| Update in adult urinary tract infection. | Urinary tract infection remains a common problem for many populations. Recent studies have expanded our understanding of the host innate immune response and its role in the familial association observed for recurrent uncomplicated urinary tract infection in healthy women. Therapeutic management for uncomplicated infection has been compromised by increasing antimicrobial resistance, particularly global dissemination of the CTXM-15 extended spectrum ß-lactamase (ESBL) producing Escherichia coli ST ... | 2011 | 21894469 |
| Changes in transcriptional orientation are associated with increases in evolutionary rates of enterobacterial genes. | Changes in transcriptional orientation ("CTOs") occur frequently in prokaryotic genomes. Such changes usually result from genomic inversions, which may cause a conflict between the directions of replication and transcription and an increase in mutation rate. However, CTOs do not always lead to the replication-transcription confrontation. Furthermore, CTOs may cause deleterious disruptions of operon structure and/or gene regulations. The currently existing CTOs may indicate relaxation of selectio ... | 2011 | 22152004 |
| Clinico-radiological features of subarachnoid hyperintensity on diffusion-weighted images in patients with meningitis. | AIM: To investigate the clinical and radiological features of meningitis with subarachnoid diffusion-weighted imaging (DWI) hyperintensity. MATERIALS AND METHODS: The clinical features, laboratory data, and radiological findings, including the number and distribution of subarachnoid DWI hyperintense lesions and other radiological abnormalities, of 18 patients seen at five institutions were evaluated. RESULTS: The patients consisted of eight males and 10 females, whose ages ranged from 4 months t ... | 2011 | 22192625 |
| a luxs-dependent transcript profile of cell-to-cell communication in klebsiella pneumoniae. | bacterial cells communicate with one another using chemical signaling molecules. the phenomenon is termed quorum sensing. the quorum sensing bacterium klebsiella pneumoniae secretes a non-homoserine lactone autoinducer in the exponential phase of growth as detected by a vibrio harveyi reporter assay for autoinducer 2 (ai-2). to further investigate regulation of ai-2 production in k. pneumoniae, the pfs and luxs promoter fusions to an operon luxcdabe reporter were constructed in a low copy number ... | 2011 | 21938276 |
| phenolic compounds and biological activity of kitaibelia vitifolia. | this study was aimed at evaluating the antioxidant activity and efficacy of the ethanolic extract of the endemic plant species kitaibelia vitifolia in inhibiting the growth of selected fungi and bacteria. antimicrobial activity was tested using the broth dilution procedure for determination of minimum inhibitory concentration (mic). mics were determined for eight selected indicator strains. the highest susceptibility to k. vitifolia ethanolic extract among the bacteria tested was exhibited by ba ... | 2011 | 21877950 |
| Efficacy of doripenem against Escherichia coli and Klebsiella pneumoniae in experimental meningitis. | OBJECTIVES: In this study the efficacy of doripenem, a new broad-spectrum carbapenem, was tested against an Escherichia coli strain and a Klebsiella pneumoniae strain in an experimental animal model. The comparator was cefepime monotherapy. METHODS: The rabbit meningitis model was used in this study and the penetration of doripenem through uninflamed and inflamed meninges was determined. RESULTS: Doripenem, injected three times (75 mg/kg), led to serum peak levels around 100 mg/L and trough leve ... | 2011 | 22178642 |
| 1,3-Dihydro-2H-indol-2-ones derivatives: design, synthesis, in vitro antibacterial, antifungal and antitubercular study. | 1,3-dihydro-2H-indol-2-ones derivatives are reported to exhibit a wide variety of biodynamic activities such as antituberculer, anti HIV, fungicidal, antibacterial, anticonvulsant. These valid observations led us to synthesize some new indole-2-one derivative. Thus, herein we report synthesis of various 5-substituted-3-[{5-(6-methyl-2-oxo/thioxo-4-phenyl-1,2,3,4 tetrahydro pyrimidin-5-yl)-1,3,4-thiadiazol-2-yl}imino]-1,3-dihydro-2H-indol-2-one derivatives 4a-l using one pot multicomponent-Bigine ... | 2011 | 21981980 |
| A case of carbapenemase-producing Klebsiella pneumoniae in Australia. | | 2012 | 22157689 |
| clinical characteristics of urosepsis caused by extended-spectrum beta-lactamase-producing escherichia coli or klebsiella pneumonia and their emergence in the community. | background: the purpose of this study is to delineate clinical characteristics of urosepsis caused by extended-spectrum beta-lactamase-producing escherichia coli and klebsiella pneumoniae (esbl-ek) in different clinical settings, with an emphasis on community-acquired infections. methods: a retrospective study was conducted at two medical centers in taiwan. from may 2002 to august 2007, clinical data of adults with urosepsis caused by esbl-ek were collected. patients were categorized into three ... | 2011 | 22041167 |
| Apoprotein isolation and activation, and vibrational structure of the Helicobacter mustelae iron urease. | The micro aerophilic pathogen Helicobacter mustelae synthesizes an oxygen-labile, iron-containing urease (UreA2B2) in addition to its standard nickel-containing enzyme (UreAB). An apoprotein form of the iron urease was prepared from ureA2B2-expressing recombinant Escherichia coli cells that were grown in minimal medium. Temperature-dependent circular dichroism measurements of holoprotein and apoprotein demonstrate an enhancement of thermal stability associated with the UreA2B2 metallocenter. In ... | 2011 | 22196017 |
| emergence of nosocomial new delhi metallo-β-lactamase-1 (ndm-1)-producing klebsiella pneumoniae in patients admitted to a tertiary care hospital in kuwait. | | 2011 | 22113192 |
| antibacterial activity of some african medicinal plants used traditionally against infectious diseases. | context: plants are known to play a crucial role in african traditional medicine for the treatment of infection diseases. objectives: to investigate the claimed antimicrobial properties of plants traditionally used in african countries, providing scientific validation for their use. materials and methods: eighty-three polar and non-polar extracts from 22 medicinal plants were screened for their antibacterial activity against gram-positive (staphylococcus aureus and enterococcus faecalis) and ... | 2011 | 22136524 |
| Plasmid-mediated resistance in enterobacteriaceae: changing landscape and implications for therapy. | Antimicrobial resistance is increasing worldwide, and pathogenic microorganisms that are resistant to all available antimicrobial agents are increasingly reported. Emerging plasmid-encoded extended-spectrum ß-lactamases (ESBLs) and carbapenemases are increasingly reported worldwide. Carbapenemase production encoded by genes located on mobile genetic elements is typically accompanied by genes encoding resistance to other drug classes, often but not necessarily located on the same mobile element. ... | 2012 | 22191792 |
| Pelvic abscess caused by New Delhi metallo-ß-lactamase-1-producing Klebsiella oxytoca in Taiwan in a patient who underwent renal transplantation in China. | | 2011 | 22083082 |
| hessian fly-associated bacteria: transmission, essentiality, and composition. | plant-feeding insects have been recently found to use microbes to manipulate host plant physiology and morphology. gall midges are one of the largest groups of insects that manipulate host plants extensively. hessian fly (hf, mayetiola destructor) is an important pest of wheat and a model system for studying gall midges. to examine the role of bacteria in parasitism, a systematic analysis of bacteria associated with hf was performed for the first time. diverse bacteria were found in different de ... | 2011 | 21858016 |
| parasitic infection improves survival from septic peritonitis by enhancing mast cell responses to bacteria in mice. | mammals are serially infected with a variety of microorganisms, including bacteria and parasites. each infection reprograms the immune system's responses to re-exposure and potentially alters responses to first-time infection by different microorganisms. to examine whether infection with a metazoan parasite modulates host responses to subsequent bacterial infection, mice were infected with the hookworm-like intestinal nematode nippostrongylus brasiliensis, followed in 2-4 weeks by peritoneal inj ... | 2011 | 22110673 |
| hemoperfusion with polymyxin b in septic shock secondary to klebsiella pneumoniae induced liver abscesses. | | 2011 | 21983271 |
| bacterial colonization or infection in chronic sinusitis. | the aim of this study was the determination of bacteria present in maxillary and ethmoid cavities in patients with chronic sinusitis and to correlate these findings with bacteria simultaneously present in their nasopharynx. the purpose of this correlation was to establish the role of bacteria found in chronically inflamed sinuses and to evaluate if the bacteria present colonized or infected sinus mucosa. nasopharyngeal and sinus swabs of 65 patients that underwent functional endoscopic sinus sur ... | 2011 | 22127467 |
| clinical predictors of pseudomonas aeruginosa or acinetobacter baumannii bacteremia in patients admitted to the ed. | the identification of clinical characteristics that could identify patients at high risk for pseudomonas aeruginosa or acinetobacter baumannii bacteremia would aid clinicians in the appropriate management of these life-threatening conditions, especially in patients admitted to the emergency department (ed) with community-onset infections. to determine clinical risk factors for p aeruginosa or a baumannii bacteremia in patients with community-onset gram-negative bacteremia (gnb), a post hoc analy ... | 2011 | 22030178 |
| novel kpc variant from a carbapenem-resistant strain of klebsiella pneumoniae in a chinese hospital. | | 2011 | 21931263 |
| massive increase, spread, and exchange of extended spectrum β-lactamase-encoding genes among intestinal enterobacteriaceae in hospitalized children with severe acute malnutrition in niger. | from the time of ctx-m emergence, extended-spectrum β-lactamase-producing enterobacteria (esbl-e) have spread worldwide in community settings as well as in hospitals, particularly in developing countries. although their dissemination appears linked to escherichia coli intestinal carriage, precise paths of this dynamic are largely unknown. | 2011 | 21890771 |
| antibacterial activity and cytotoxicity of selected egyptian medicinal plants. | medicinal plants have been used as a source of remedies since ancient times in egypt. the present study was designed to investigate the antibacterial activity and the cytotoxicity of the organic extracts from 16 selected medicinal plants of egypt. the study was also extended to the isolation of the antiproliferative compound jaeschkeanadiol p-hydroxybenzoate (fh-25) from ferula hermonis. the microbroth dilution was used to determine the minimal inhibitory concentration (mic) of the samples aga ... | 2011 | 22057918 |
| ndm-1-producing klebsiella pneumoniae in mauritius. | | 2012 | 22006002 |
| synthesis and biological evaluation of some thiazolidinones as antimicrobial agents. | a novel series of thiazolidinone derivatives namely 4-(4-dimethylamino-6-{4-[5-(4-ethylpiperazin-1-ylmethyl)-4-oxo-2-phenylthiazolidin-3-yl]-phenylamino}-[1,3,5]triazin-2-yloxy)-1-methyl-1h-quinolin-2-one have been synthesized from the key intermediate 4-[4-(4-aminophenylamino)-6-dimethylamino-[1,3,5]triazin-2-yloxy]-1-methyl-1h-quinolin-2-one (7). condensation reaction of compound 7 with different aldehyde derivatives were performed to obtain schiff base derivatives, which after cyclization gav ... | 2011 | 22182927 |
| asian sand dust enhances murine lung inflammation caused by klebsiella pneumoniae. | inhaling concomitants from asian sand dust (asd) may result in exacerbation of pneumonia by the pathogen. the exacerbating effect of asd on pneumonia induced by klebsiella pneumoniae (kp) was investigated in icr mice. the organic substances adsorbed onto asd collected from the atmosphere of iki-island in japan were excluded by heat treatment at 360°c for 30min. icr mice were instilled intratracheally with asd at doses of 0.05mg or 0.2mg/mouse four times at 2-week intervals (total dose of 0.2mg o ... | 2011 | 22118940 |
| incidence and etiology of omphalitis in pakistan: a community-based cohort study. | although omphalitis (umbilical infections) among newborns is common and a major cause of neonatal deaths in developing countries, information on its burden and etiology from community settings is lacking. this study aimed to determine the incidence and etiology of omphalitis in newborns in high neonatal mortality settings in karachi, pakistan. | 2011 | 22169780 |
| gut-mediated and hla-b27-associated arthritis: an emphasis on ankylosing spondylitis and crohn's disease with a proposal for the use of new treatment. | ankylosing spondylitis (as) and crohn's disease (cd), especially when associated with spondylitis are interrelated conditions included within the categories of spondyloarthropathic disease entities. they share some common clinical, genetic, and microbiological findings. an extensive amount of studies which have been carried out by various independent groups throughout the world have shown that klebsiella pneumoniae microorganisms could be suggested as the most likely etiopathogenetic triggers fo ... | 2011 | 21955846 |
| investigation of the antibacterial activity of pioglitazone. | to evaluate the antibacterial potential of pioglitazone, a member of the thiazolidinediones class of drugs, against gram-positive (streptococcus pneumoniae) and gram-negative (escherichia coli and klebsiella pneumoniae) bacteria. | 2011 | 22087061 |
| Composition and antibacterial activity of essential oil from Scutellaria grossa Wall ex Benth. | The chemical composition of the steam volatile oil of the whole aerial part of Scutellaria grossa Wall ex Benth. (Lamiaceae), obtained by steam distillation, has been analysed by capillary GC and GC-MS. The oil was found to be rich in oxygenated monoterpenes (88.6%). A total of 50 constituents were identified, representing 94.4% of the total oil composition. Linalool (37.0%) and 1-octen-3-ol (32.0%) were found to be the principal constituents. The antibacterial activity of the oil was determined ... | 2012 | 22060314 |
| antimicrobial activity and phytochemical screening of serial extracts from leaves of aegle marmelos (linn.). | the in vitro antimicrobial activity of serial petroleum ether, chloroform and methanol extracts from leaves of aegle mawmelos were investigated against bacterial and fungal species. all the extracts exhibited broad spectrum antimicrobial activity with zones of inhibition ranging from 10 to 22 mm against bacteria: staphylococcus aureus, beta streptococcus haemolyticus group a, proteus mimrabilis, klebsiella pneumoniae, pseudomonas aenrginosa, escherichia coli, salmonella typhi, fungi: candida alb ... | 2011 | 21928713 |
| catecholthioether derivatives: preliminary study of in-vitro antimicrobial and antioxidant activities. | in this research, synthesis, antimicrobial and antioxidant activities of a series of catecholthioethers having benzoxazole and tetrazole moieties are described. antimicrobial activity was evaluated by minimum inhibitory concentration (mic) assay. the synthesized compounds were tested in vitro against three gram-positive bacteria including staphylococcus aureus (clinical isolated), staphylococcus aureus atcc 25922, enterococcus faecium (clinical isolated), and two gram-negative bacteria including ... | 2011 | 21881259 |
| fournier's gangrene in a patient receiving treatment for idiopathic thrombocytopenic purpura. | we report the case of a 68-year-old man who was diagnosed with fournier's gangrene (fg), which developed during immunosuppresive treatment for idiopathic thrombocytopenic purpura (itp). the patient was administered steroids for itp but on the 36th day, he developed fg and septic shock. we initiated antibiotic treatment and drained a periproctal abscess immediately. on day 53, extensive drainage to progressive fg and a splenectomy was performed, following which both fg and thrombocytopenia improv ... | 2011 | 21921388 |
| the role of klebsiella pneumoniae rmpa in capsular polysaccharide synthesis and virulence revisited. | klebsiella pneumoniae community-acquired pyogenic liver abscess (pla) is an emerging infectious disease. the rmpa gene (for regulator of mucoid phenotype a) has been reported to be associated with pla in prevalence studies. ntuh-k2044, a k1 pla isolate, carries three rmpa/a2 genes: two large-plasmid-carried genes (p-rmpa and p-rmpa2) and one chromosomal gene (c-rmpa). in this study, we re-examined the role of rmpa/a2 in pla pathogenesis to clarify the relationship of rmpa/a2 and capsular serotyp ... | 2011 | 21964731 |
| hepg2 cells infected with klebsiella pneumoniae show dna laddering at apoptotic and necrotic stages. | virulent klebasiella pneumoniae (kp) inflicts severe liver abscesses in infected patients. this study investigated how the bacterial infection affected cell survival at the molecular level, in a cultured cell model. a strain of kp highly virulent in mice was isolated from a patient with liver abscess, and was used to infect hepg2 cells. the infected cells were examined for their viability, dna fragmentation, and proteins involved in apoptosis or necrosis. we found that the infection decreased th ... | 2011 | 22038342 |
| A cautionary case of microbial solidarity: concurrent isolation of VIM-1-producing Klebsiella pneumoniae, Escherichia coli and Enterobacter cloacae from an infected wound. | | 2012 | 21969331 |
| imp-producing carbapenem-resistant klebsiella pneumoniae in the united states. | the emergence and spread of carbapenem-resistant enterobacteriaceae (cre) producing acquired carbapenemases have created a global public health crisis. in the united states, cre producing the klebsiella pneumoniae carbapenemase (kpc) are increasingly common and are endemic in some regions. metallo-β-lactamase (mbl)-producing cre have recently been reported in the united states among patients who received medical care in countries where such organisms are common. here, we describe three carbapene ... | 2011 | 21998425 |
| identification of a plasmid-borne blaimp-11 in clinical isolates of escherichia coli and klebsiella pneumoniae. | the acquired metallo-β-lactamases (mbls) represent a significant clinical threat due to their unrivalled hydrolysis spectrum and their resistance to therapeutic inhibitors of β-lactamase. in this study, we identified plasmid- and integron-borne bla(imp-11) in clinical isolates of escherichia coli and klebsiella pneumoniae. the bla(imp-11) gene cassette was carried by a typical class 1 integron together with aaca1 and orfg gene cassettes. the integron, inti1-bla(imp-11)-aaca1-orfg-qaced1-sul1, wa ... | 2011 | 21940655 |
| molecular epidemiology of mastitis pathogens of dairy cattle and comparative relevance to humans. | mastitis, inflammation of the mammary gland, can be caused by a wide range of organisms, including gram-negative and gram-positive bacteria, mycoplasmas and algae. many microbial species that are common causes of bovine mastitis, such as escherichia coli, klebsiella pneumoniae, streptococcus agalactiae and staphylococcus aureus also occur as commensals or pathogens of humans whereas other causative species, such as streptococcus uberis, streptococcus dysgalactiae subsp. dysgalactiae or staphyloc ... | 2011 | 21968538 |
| detection of betalactamase producing bacterial genes and their clinical features. | the present study was aimed to identify the gene of drug resistance betalactamase producing bacteria and clinical features of the infected patients at hospital university kebangsaan malaysia. blood samples from the patients were collected, processed and betalactamase producing drug resistance bacteria were identified by antibiotic sensitivity testing. genes of the drug resistance bacteria were detected and characterized by polymerase chain reaction. a total of 34 isolates of drug resistance beta ... | 2011 | 21913496 |
| organ transplantation from a donor colonized with a multidrug-resistant organism: a case report. | the number of intensive care unit patients with infections caused by multidrug-resistant organisms is increasing in most developed countries. we report the case of a deceased multiorgan donor, who was an asymptomatic carrier of carbapenem-resistant klebsiella pneumoniae (cr-kp) in the respiratory tract, a condition that was not diagnosed before organ harvesting and transplantation. the outcome of the 2 kidney recipients, the liver recipient, and 1 of the lung recipients was uneventful; in partic ... | 2011 | 22176504 |
| [changes in the incidence of multiresistant pathogens and its consequences in the intensive care unit]. | incidence of nosocomial infections and antibiotics resistance in intensive care units is increasing worldwide. blood-stream infections of gram-negative non-fermentive bacteria are associated with higher mortality. | 2011 | 21893479 |
| characterization of phragmites cummunis rhizosphere bacterial communities and metabolic products during the two stage sequential treatment of post methanated distillery effluent by bacteria and wetland plants. | this study deals with the characterization of rhizosphere bacterial communities and metabolic products produced during the two stage sequential treatment of post methanated distillery effluent by bacteria and constructed wetland plants. results showed that bacterial treatment followed by wetland plants (phragmites cummunis) resulted 94.5% and 96.0% reduction in bod and cod values, respectively. the pcr-rflp analysis showed the presence of stenotrophomonas, enterobacter, pantoea, acinetobacter an ... | 2012 | 22047662 |
| antimicrobial susceptibility of bacterial pathogens associated with community-acquired respiratory tract infections in asia: report from the community-acquired respiratory tract infection pathogen surveillance (cartips) study, 2009-2010. | a multicentre resistance surveillance study [community-acquired respiratory tract infection pathogen surveillance (cartips)] investigating the susceptibilities of 2963 clinical isolates of streptococcus pneumoniae, haemophilus influenzae, moraxella catarrhalis, klebsiella pneumoniae, meticillin-susceptible staphylococcus aureus (mssa) and streptococcus spp. from asia against 12 antimicrobial agents was undertaken from 2009 to 2010. based on the breakpoints for oral penicillin v recommended by th ... | 2011 | 21880469 |
| antibiotic sensitivity profile of bacterial pathogens in postoperative wound infections at a tertiary care hospital in gujarat, india. | to find out the most common bacterial pathogens responsible for post-operative wound infection and their antibiotic sensitivity profile. | 2011 | 21897707 |
| antimicrobial and toxicological activities of five medicinal plant species from cameroon traditional medicine. | infectious diseases caused by multiresistant microbial strains are on the increase. fighting these diseases with natural products may be more efficacious. the aim of this study was to investigate the in vitro antimicrobial activity of methanolic, ethylacetate (etoac) and hexanic fractions of five cameroonian medicinal plants (piptadeniastum africana, cissus aralioides, hileria latifolia, phyllanthus muellerianus and gladiolus gregasius) against 10 pathogenic microorganisms of the urogenital and ... | 2011 | 21867554 |
| high prevalence of blactx-m in enterobacteriaceae isolates from the kingdom of bahrain. | to determine the molecular epidemiology of extended-spectrum β-lactamase (esbl) by testing a cohort of clinical esbl-producing bacterial isolates that were isolated in the kingdom of bahrain. | 2011 | 22118027 |
| strains of klebsiella pneumoniae producing extended spectrum beta-lactamases, isolated from organ recipients. | the aims of this work were to define the effectiveness of identification of the extended-spectrum beta-lactamases (esbl) phenotype, and to define the genotype of klebsiella pneumoniae β-lactamase. | 2011 | 21996244 |
| mobilizable narrow host range plasmids as natural suicide vectors enabling horizontal gene transfer among distantly related bacterial species. | klebsiella pneumoniae 287-w carries three small narrow host range (nhr) plasmids (pigms31, pigms32, and pigrk), which could be maintained in several closely related species of gammaproteobacteria, but not in alphaproteobacteria. the plasmids contain different mobilization systems (mob), whose activity in escherichia coli was demonstrated in the presence of the helper transfer system originating from plasmid rk2. the mobs of pigms31 and pigms32 are highly conserved in many bacterial plasmids (mem ... | 2012 | 22092700 |
| synthesis and kinetic testing of new inhibitors for a metallo-β-lactamase from klebsiella pneumonia and pseudomonas aeruginosa. | there are currently no clinically useful inhibitors against metallo-β-lactamases (mbls), enzymes that confer resistance against a broad spectrum of commonly used antibiotics and that are produced by an increasing number of bacterial pathogens. new pyrrole derivatives were synthesized and assayed for their inhibitory effect on the catalytic activity of the imp-1 mbl from pseudomonas aeruginosa and klebsiella pneumoniae. six compounds tested (3a-3c, 5, 7 and 8) show micromolar inhibition constants ... | 2011 | 22051063 |
| microbiological quality of drinking water from dispensers in roadside restaurants of bangladesh. | the microbiological status of water from dispensers in different roadside restaurants of dhaka city and savar area was analyzed in this study. seven samples from dhaka and 8 samples of savar were checked. the heterotrophic plate count was in a range of 1.0 x 10(3) cfu ml(-1) to 2.0 x 10(4) cfu ml(-1) (from new bottles), 1.0 x 10(3) to 1.5 x 10(4) cfu ml(-1) (after dispensation), and 1.5 x 10(3) cfu ml(-1) to 1.0 x l0(5) cfu ml(-1) (from serving glass). in several of the samples, the heterotrophi ... | 2011 | 21916267 |
| risk and causes of paediatric hospital-acquired bacteraemia in kilifi district hospital, kenya: a prospective cohort study. | in sub-saharan africa, community-acquired bacteraemia is an important cause of illness and death in children. our aim was to establish the magnitude and causes of hospital-acquired (nosocomial) bacteraemia in african children. | 2011 | 22133536 |
| in vitro activity of tigecycline and comparators against gram-negative pathogens isolated from blood in europe (2004-2009). | here we report on the antimicrobial resistance amongst gram-negative isolates (excluding acinetobacter spp.) collected from blood culture sources at european study sites as part of the global tigecycline evaluation and surveillance trial (t.e.s.t.) from the study start in 2004 until august 2009. all isolates were collected and tested for minimum inhibitory concentrations using clinical and laboratory standards institute methodology. over the collection period, extended-spectrum β-lactamase (esbl ... | 2011 | 22189391 |
| [antimicrobial resistance pattern for gram-negative uropathogens isolated from hospitalised patients and outpatients in cartagena, 2005-2008]. | determining the microbial aetiology spectrum and antibiotic resistance pattern of uropathogens causing urinary tract infections in hospitalised patients and outpatients. | 2010 | 22030688 |
| extended-spectrum beta-lactamase orthopedic wound infections in nigeria. | extended-spectrum beta-lactamase (esbl)-producing gram-negative bacteria are emerging and impacting significantly on the management of patients and hospital costs. besides, they are not being routinely sought after in diagnostic laboratories thus contributing to treatment failure. | 2011 | 21887050 |
| the effect of recurrent episodes of clinical mastitis caused by gram-positive and gram-negative bacteria and other organisms on mortality and culling in holstein dairy cows. | the objective of this study was to estimate the effects of recurrent episodes of different types of clinical mastitis (cm) caused by gram-positive (streptococcus spp., staphylococcus aureus, staphylococcus spp.) and gram-negative (escherichia coli, klebsiella, citrobacter, enterobacter, pseudomonas) bacteria, and other organisms (arcanobacterium pyogenes, mycoplasma, corynebacterium bovis, yeast, miscellaneous) on the probability of mortality and culling in holstein dairy cows. data from 30,233 ... | 2011 | 21943738 |
| emergence of an autochthonous and community-acquired ndm-1-producing klebsiella pneumoniae in europe. | | 2012 | 21960718 |
| demographic features and antibiotic resistance among children hospitalized for urinary tract infection in northwest iran. | urinary tract infection (uti) is the most common serious bacterial infection during infancy. the aim of the present study was to evaluate demographic characteristics, clinical presentations and findings, and antimicrobial resistance among infants and children hospitalized in tabriz children's hospital, tabriz, iran. | 2011 | 22114509 |
| isolation and characterization of klebsiella oxytoca strain degrading crude oil from a tunisian off-shore oil field. | a facultatively anaerobic, gram-negative, mesophilic, moderately halotolerant, non-motile, and non-sporulated bacterium, designated strain bsc5 was isolated from an off-shore "sercina" oil field, located near the kerkennah island, tunisia. yeast extract was not required for growth. phenotypic characteristics and phylogenetic analysis of the 16s rrna gene sequence of strain bsc5 revealed that it was related to members of the genus klebsiella, being most closely related to the type strain of k. ox ... | 2011 | 22144124 |