| effect of vaccination schedule on immune response of macaca mulatta to cell culture-grown rocky mountain spotted fever vaccine. | the effect of vaccination schedule on the immune response of macaca mulatta to formalin-inactivated chicken embryo cell culture (cec)-grown rickettsia rickettsii vaccine was studied. schedules consisted of inoculation on day 1 only, on days 1 and 15, on days 1 and 30, on days 1, 8, and 15, or on days 1, 15, and 45. humoral antibody measured by microagglutination and indirect immunofluorescence and resistance to challenge with 10(4) plaque-forming units of yolk sac-grown r. rickettsii were assess ... | 1976 | 823173 |
| areal and laminar distribution of some pulvinar cortical efferents in rhesus monkey. | the areal and laminar distribution of the cortical efferents of the medial, lateral and inferior pulvinar nuclei (pm, pl and pi respectively) were determined in rhesus monkey using autoradiography and horseradish peroxidase (hrp). the autoradiographic data indicated that: areas 8a, 45 and 46 on the convexity and 11 and 12 on the orbital surface of the frontal lobe received projections from pm; areas 20, 21 and 22 in temporal lobe received projections from pm primarily with caudal-medial parts of ... | 1976 | 823181 |
| relationship of topical dose and percutaneous absorption in rhesus monkey and man. | [14c]testosterone, [14c]hydrocortisone, and [14c]benzoic acid were applied to skin of the rhesus monkey and man, and percutaneous absorption was quantitated by measuring urinary excretion of 14c. in the rhesus, the concentration of testosterone was increased from 4 to 4000 mug/cm2 in 5 steps. the efficiency of absorption decreased from 18.4 +/- 9.5% to 1.4 +/- 0.8%. however, the total compound absorbed (per cm2 area) always increased, from a low of 0.7mug to 56 mug. in man, testosterone penetrat ... | 1976 | 823268 |
| influence of handling and sedation on plasma cortisol in rhesus monkeys (macaca mulatta). | | 1976 | 823287 |
| activities of some enzymes involved in homocysteine methylation in brain, liver and kidney of the developing rhesus monkey. | | 1976 | 823296 |
| organization of monkey superior colliculus: intermediate layer cells discharging before eye movements. | 1. we investigated the characteristics of cells in the intermediate layers of the superior colliculus that increase their rate of discharge before saccadic eye movements. eye movements were repeatedly elicited by training rhesus monkeys to fixate on a spot of light and to make saccades to other spots of light when the fixation spot was turned off. 2. the eye movement cells showed consistent variations with their depth within the colliculus. the onset of the cell discharge led the eye movement by ... | 1976 | 823302 |
| treatment of experiment delayed cerebral arterial spasm with a beta2-adrenergic stimulator and a phosphodiesterase inhibitor. | delayed cerebral arterial spasm was induced by subarachnoid hemorrhage in 11 rhesus monkeys. ten monkeys (62%) developed spasm. of seven monkeys treated with salbutamol (a beta2-adrenergic stimulating drug), five had relief of vasospasm. four monkeys, one of which had failed to respond to salbutamol alone, were treated with salbutamol and aminophylline (a phosphodiesterase-inhibiting drug), and all four were relieved of their vasospasm. when considered as one group, the monkeys had an 81% respon ... | 1976 | 823307 |
| primate model for testing periodontal treatment procedures: ii. production of contralaterally similar lesions. | experimental periodontal pockets were produced bilaterally in four rhesus monkeys. the pockets were analyzed histometrically and the resultant data were subjected to statistical analysis. there were but few significant differences between pockets on contralateral tooth surfaces, and in each case, the magnitudes of the observed differences were so small as to be of no biological significance. the use of this model system for future studies on periodontal treatment was discussed. it was shown that ... | 1976 | 823319 |
| comparative biologic responses to various methyl methacrylate bone substitutes. | four methyl methacrylate bone substitutes were investigated in bilateral multiple bone defects in the femurs of five rhesus monkeys and five mongrel dogs. the animals were sacrificed at 2, 4, 6, 8, and 10 weeks postoperatively. on the basis of clinical, radiologic, and histologic examination, the cranioplast evoked the least severe inflammatory response ans was the best biologic bone substitute when compared to adaptic, sevitron, and lucitone. | 1976 | 823324 |
| ultrastructural study of plasmodium knowlesi antigen used in vaccination of rhesus monkeys. | material from various steps obtained in the french pressure cell technic of preparing antigen from plasmodium knowlesi-infected red cells, was examined by elctron microscopy. a positively charged colloidal iron solution was used to differentiate between membranes of host red cells and parasites. red cell membranes take the stain, wheras parasite membranes do not. this antigen which has been used previously to protect monkeys against p. knowlesi appears to consist almost entirely of membrane-boun ... | 1976 | 823328 |
| effect of hcg on testicular function in juvenile rhesus monkeys (macaca mulatta). | the effect of human chroionic gonadotropin (hcg) on the testes was studied in 7 juvenile rhesus monkeys in vitro. the histological appearance of control testes was similar, and unilateral castration did not produce any marked effect on the weight of the remaining testes. treatment with hcg brought about an increase in testicular weight accompanied by hyperplasia of the intertubular tissue. many areas of the testes had interstitial cells characterized by their large size and eosinophilic cytopl ... | 1976 | 823333 |
| failure of commercially prepared isoniazid diet to produce isoniazid serum concentrations in rhesus monkeys. | a comparison was made of serum isoniazid concentrations and the time course of isoniazid elimination in rhesus monkeys given the drug im, orally on sugar cubes, or in a commercially medicated diet. when the drug was administered orally on sugar cubes or im, peak serum concentrations were usually reached within 2 hr. a threefold individual variation in the rate of elimination was noted, and in most animals the serum concentration at 6 hr approached zero. isoniazid was not detected in the serum of ... | 1976 | 823367 |
| severe polyarthritis in a rhesus monkey: suggested mycoplasma etiology. | a female juvenile rhesus monkey experienced a 3-wk period of vague lameness and limb disuse, followed by a severe attack of acute polyarthritis resulting in marked radiographic changes. the acute condition lasted about 3 wk and was followed by a chronic but active condition lasting another 13 mo until the animal was killed. although a causative organism was not isolated, serologic and clinical laboratory data and histopathologic results were presented which suggest a diagnosis of mycoplasma poly ... | 1976 | 823370 |
| obstructive gastric foreign body in a rhesus monkey (macaca mulatta). | weight loss and depression were the principal signs in a case of obstructive gastric foreign body resulting from the ingestion of pine wood fragments by a rhesus monkey. this was the second case of its kind to occur in a short period. replacement of the monkeys' pine wood resting platforms with platforms made of oak eliminated the problem. | 1976 | 823371 |
| a chest harness and pole-leash for routine transfer of rhesus monkeys from home cage to behavioral test apparatus and back. | a chest harness and pole-leash method to transfer rhesus monkeys (macaca mulatta) weighing up to 16 kg from home cage to primate restraint chair was designed. the harness was made of leather straps that crossed the chest in an x-fashion, and created a v-neck. the v-neck eliminated the strangulation hazard of neck collars, and minimized interference between the harness and neck hole of restraint chairs. two pole-leashes attached to 2 points on the harness gave the handler considerable control ove ... | 1976 | 823373 |
| in vitro generation of a chemically reactive metabolite of 2,5,2',5'-tetrachlorobiphenyl by rhesus monkey liver microsomes. | incubation of tritiated 2,5,2',5'-tetrachlorobiphenyl with normal monkey liver microsomes in a nadph-generating system results in the formation of active metabolite(s) of the [3h]2,5,2',5'-tetrachlorobiphenyl capable of covalently binding to rna and protein isolated from the incubation mixture. the metabolite is not formed when the control microsomes are held at 100 degrees for 10 min prior to incubation. the addition of microsomal supernate to the solution causes an increase in the binding of t ... | 1976 | 823554 |
| delta-9-thc and nonverbal communication in monkeys. | male rhesus monkeys were trained to perform an instrumental avoidance conditioned response. they were then paired in the "cooperative conditioning" paradigm, a situation designed to measure the quality of nonverbal communication by changes in facial expression. a "responder monkey" was able to perform discriminated instrumental avoidance responses by processing facial expressive cues provided through a closed circuit television picture of a "stimulus monkey" which was receiving presentations of ... | 1976 | 823573 |
| absence of pathological changes following intravenous methamphetamine and intra-arterial iothalamate meglumine. | eleven rhesus monkeys received injections of intravenous methamphetamine hydrochloride (desoxyn) and/or intra-arterial 60% iothalamate meglumine (conray) according to a schedule previously reported to produce marked radiological and pathological changes in the cerebral vasculature of the rhesus monkey. while radiological changes consistent with impaired cerebral circulation were observed, they could not be correlated directly with the administration of intravenous methamphetamine because of the ... | 1976 | 823618 |
| the diencephalon of the vervet monkey (cercopithecus aethiops). part i: thalamus and metathalamus. | the diencephalon of the vervet monkey (cercopithecus aethiops) is described and compared with that of other primates, particularly the macaque monkey (macaca mulatta). in the vervet monkey, the thalamus is divided into six nuclear groups: anterior, midline, medial, dorsolateral, ventrolateral and posterior. the anterior nuclear group shows a regressive nucleus anterodorsalis and a poorly defined demarcation between the nuclei anteromedialis and anteroventralis. there is a large interthalamic adh ... | 1976 | 823649 |
| morphological effects of hexachlorobenzene toxicity in female rhesus monkeys. | | 1976 | 823668 |
| prevalence of toxoplasma antibodies in rhesus monkeys in india. | a serological survey of toxoplasma antibodies prevalent in rhesus monkeys in india using an indirect haemagglutination test is reported. of 94 monkeys 56.4 percent were positive to an antibody titre of 1:8 or more, 28.7 percent to a titre of 1.32 or more, while 17 percent showed a positivity level of 1:128 or more. the significance of these findings is discussed. | 1976 | 823673 |
| nystagmic responses of the rhesus monkey to rotational stimulation following unilateral labyrinthectomy: a preliminary report. | | 1976 | 823677 |
| a visual deficit after superior colliculus lesions in monkeys. | the superior colliculus has been implicated in visual orientation and localization in several mammalian species. to examine this possibility in rhesus monkeys, we trained monkeys to respond to one of six locations signaled by a small light of 5 s duration that was turned off immediately before they were allowed to respond. the locations were directly behind the light. after tectal lesions they continued to perform this task normally, but showed a severe deficit when the duration of the signal wa ... | 1976 | 823800 |
| cholinergic innervation of the simian oxyntic gastric mucosa. | the innervation of the oxyntic gastric mucosa was studied by light and electron microscopy in the rhesus monkey. an abundant net of acetylcholinesterase-positive nerves was seen in the lamina propria, with many slender fibers noted close to the basal lamina of the glands. electron microscopic observation disclosed the presence of nerve fibers containing axons and varicosities in the lamina propria, often in very close proximity to the epithelial glandular cells. nerve endings partly enveloped by ... | 1976 | 823812 |
| nutritional studies in the pregnant rhesus monkey--the effect of protein-calorie or protein deprivation on growth of the fetal brain. | twenty four pregnant nulliparous rhesus monkeys were distributed in three groups. while pregnant, the mothers were fed a diet, adequate in mineral and vitamins, that afforded 4.2 g protein and 100 cal; 1.2 g protein and 100 cal; or 1.2 g protein and 50 cal per kg per day. the fetuses were taken by cesarian section at 156 days gestation (term = 165 days) and the cerebrum and cerebellum were subsequently analysed chemically to assess composition and growth. analyses revealed no statistically signi ... | 1976 | 823816 |
| intraocular irrigating solutions and lens clarity. | by in vitro incubation of rhesus monkey lenses at 37degreesc, we determined that solutions superior to intraocular irrigating solutions in common clinical use could be prepared by aspetically adding commerically available solutions of dextrose 5% in water and sodium bicarbonate to either ringer's injection or ringer's lactate solutions. while not as effective as glutathione-bicarbonate-ringer's solution (g-b-r) in maintaining lens clarity, these mixtures can be prepared easily in the operating r ... | 1976 | 823823 |
| diazepam treatment of socially isolated monkeys. | four rhesus monkeys were reared for the first eight months of life in total social isolation. one animal died during this period; the three remaining subjects were treated with diazepam in an isolation chamber, in their home cages, and in a playroom testing situation. diazepam significantly decreased the self-disturbance behaviors of two subjects, and there was even the appearance of some social behaviors, although they were limited and not of the same quality as in nonisolated subjects. the aut ... | 1976 | 823827 |
| the metabolism of oxamniquine - a new schistosomicide. | the metabolism of oxamniquine, 6-hydroxymethyl-7-nitro-2-isopropylaminomethyl-1,2,3,4-tetrahydroquinoline, has been studied in the mouse, rat, hamster, rabbit, rhesus monkey, dog and man. urinary excretion is a major route of elimination in man. the compound is converted to two metabolites, the major one arising from oxidation of the 6-hydroxymethyl group to a carboxyl group and the other by oxidation of the side chain to give the 2-carboxylic acid. there is a species at the dose levels used sin ... | 1976 | 823880 |
| recovery of uterine embryos in rhesus monkeys. | | 1976 | 823983 |
| behavioural activity in the monkey (macaca mulatta) of the metabolites of diazepam in man [proceedings]. | | 1976 | 823999 |
| comparison of the self-administration liabilities of morphine and pentazocine in the rhesus monkey [proceedings]. | | 1976 | 824001 |
| temporal neocortical afferent connections to the amygdala in the rhesus monkey. | the temporal neocortical afferent connections to the amygdala were investigated in the rhesus monkey using the silver impregnation and autoradiographic tracing methods. a large topographically organized projection to the amygdala was found to originate from the anterior superior temporal gyrus (area ta), the anterior middle and inferior temporal gyri (area te), and the medial and lateral aspects of the temporal pole (area tg). these projections terminate in discrete adjacent regions of the later ... | 1976 | 824015 |
| autoradiographic demonstration of a projection from prefrontal association cortex to the superior colliculus in the rhesus monkey. | | 1976 | 824019 |
| transport of 5-hydroxy-3-indoleacetic acid by spinal cord during subarachnoid perfusion. | the transport of [14c]5-hydroxy-3-indoleacetic acid (5-hiaa) by the spinal cord was investigated with spinal subarachnoid perfusions of 20 rhesus monkeys. for spinal white matter, [14c]5-hiaa was found to distribute in a tissue space of 50-55% and to exchange readily between tissue and blood across parenchymal capillaries. the data were analyzed with a model of the spinal cord as a cylinder and a mean capillary transfer half-time of 20 min determined. the spinal cord cleared [14c]5-hiaa from 19 ... | 1976 | 824024 |
| spinal projections from the nucleus locus coeruleus and nucleus subcoeruleus in the cat and monkey as demonstrated by the retrograde transport of horseradish peroxidase. | the rostral pons of the cat and rhesus monkey were examined for the presence of labeled cells following injections of horseradish peroxidase (hrp) into the lumbar spinal cord. labeled cells were found in the ipsilateral dorsolateral pontine tegmentum and in the contralateral ventrolateral pontine reticular formation. in both the cat and monkey, labeled cells were located in the nucleus locus coeruleus, nucleus subcoeruleus, in or near the kölliker-fuse nucleus, and in the ventral part of the lat ... | 1976 | 824030 |
| influences of copper and design of intrauterine devices on endometrial bleeding in monkeys. | uterine bleeding in 8 rhesus monkeys was compared in response to plain vs. a specially fitted copper-wrapped iud. all animals had utero-cutaneous surgical fistulas for accurate iud insertion and removal. daily observations for uterine bleeding between menstruations and quantitation of menstrual blood loss (mbl) were made. following control periods of observation, each monkey was inserted with either a plain or a copper-wrapped iud and then studied for 4 consecutive menstrual periods. each iu ... | 1976 | 824096 |
| plasma levels of medroxyprogesterone acetate (mpa), estradiol and progesterone in the rhesus monkey after intramuscular adminstration of depo-provera. | plasma levels of medroxyprogesterone acetate (mpa), estradiol, and p rogesterone in the rhesus monkey after im administration of depo-provera were studied. an injection of 150 mg mpa resulted in initially high blood levels of mpa until 3 weeks postinjection in 4 mature cycling monkeys. mpa levels were below .5 ng/ml 70, 83, 90, and 150 days postinjection. ovulatory rises of progesterone were detected 101, 113, 123, and 233 days postinjection. a parallel study revealed that the same dose of m ... | 1976 | 824097 |
| distribution of [3h] thymidine in the lends of the rhesus monkey (macaca mulatta) embryo. | | 1976 | 824150 |
| oxygen tension in the oviduct of the rhesus monkey (macaca mulatta). | the oxygen tension in the oviductal fluid of adult female rhesus monkeys was measured by means of miniaturized, flexible, oxygen probes between days 5 and 22 of the menstrual cycle. in the follicular phase, the value was very low, less than 10 torr. at the time of ovulation to about 5 to 7 days thereafter, the oxygen tension in the tube on the side of ovulation increased within approximately 2 minutes after insertion of the oxygen probe from the low level to the same value as in the blood. in th ... | 1976 | 824161 |
| the corneal penetration of 6-aminohexanoic acid. | 6-aminohexanoic acid is a potent antifibrinolytic agent with the ability to retard dissolution of fibrin clots. the corneal penetration of 6-aminohexanoic acid was measured to determine if therapeutic levels of the drug could be maintained in the anterior chamber by topical administration. the conjunctival sac to anterior chamber transfer coefficient was found to be 1.51 x 10-4 +/- 0.20 x 10-4 per minute and the corneal permeability found to be 3.46 x 10-7 +/- 0.46 x 10-7 cm. per second in the r ... | 1976 | 824225 |
| naturally occurring tuberculosis in a squirrel monkey and a cebus monkey. | tuberculosis was detected in a brazilian squirrel monkey (saimiri sciureus) and in a cebus monkey (cebus apella). both of these animals were housed in the same room with a rhesus monkey (macaca mulatta) subsequently found to be tuberculous. all 3 of the monkeys died within a 4-month period. | 1976 | 824261 |
| identification of a novel enterotoxigenic activity associated with bacillus cereus. | a strain of bacillus cereus isolated from a food poisoning outbreak characterized by vomiting has been shown to be capable of causing vomiting when cultures grown on rice, but not other media, were fed to rhesus monkeys. in contrast, a strain isolated from a diarrhoeal outbreak produced diarrhoea, but not vomiting, when grown on various media in similar feeding trials. furthermore, culture filtrates from the diarrhoeal strain caused fluid accumulation in ligated rabbit ileal loops whereas those ... | 1976 | 824324 |
| prostaglandins in the plasma and amniotic fluid of rhesus monkeys during pregnancy and after intra-uterine foetal death. | prostaglandin f (pgf) was measured in amniotic fluid, and 13,14-dihydro-15-keto-prostaglandin f2 alpha (pgfm) was measured in maternal peripheral venous plasma and amniotic fluid of rhesus monkeys during late pregnancy. 13,14-dihydro-15-keto-pgf2 alpha was determined in the maternal peripheral venous plasma of two animals following intra-uterine foetal death. the mean concentration of pgf and pgfm in amniotic fluid increased fourfold during the last 5 days of pregnancy. this increase was associa ... | 1976 | 824394 |
| trigeminothalamic neurons in nucleus caudalis responsive to tactile, thermal, and nociceptive stimulation of monkey's face. | 1. a total of 113 trigeminothalamic neurons and over 200 presumed interneurons of nucleus caudalis (0-5 mm below the obex) and subjacent reticular formation were studied in rhesus monkeys anesthetized with chloralose or nitrous oxide. each cell was characterized in terms of its antidromic responses to stimulation of ventral posterior medial and/or posterior thalamic nuclei and to three types of stimuli applied to its receptive field: a) graded 5-s temperature shifts at a rate of 9 degrees c/s fr ... | 1976 | 824411 |
| effect of acute spinal cord compression injury on regional spinal cord blood flow in primates. | spinal cord blood flow (scbf) was measured in 24 rhesus monkeys after injury to the cord produced by the inflatable circumferential extradural cuff technique. measurement of regional blood flow in the white and gray matter of the cord in areas of 0.1 sq mm was achieved with the 14c-antipyrine autoradiographic technique and a scanning microscope photometer. after moderate cord injury (400 mm hg pressure in the cuff maintained for 5 minutes), which produced paraplegia in 50% of animals and moderat ... | 1976 | 824418 |
| absorption, distribution, metabolism, and excretion of furosemide in dogs and monkeys i: analytical methodology, metabolism, and urinary excretion. | 35s-furosemide was administered to beagle dogs and rhesus monkeys in an oral solution on a single and a 20 repeated 5-mg/kg/day dosing regimen. following the single dose, 25.0% (dogs) and 24.0% (monkeys) of the dose were excreted in the urine in 24 hr. tlc analysis demonstrated that both species had similar excretory patterns; i.e., over 80% of the amount excreted in the urine was present as unchanged durosemide and the remainder was composed of a known metabolite, saluamine, and an as yet unide ... | 1976 | 824434 |
| behavior maintained under a second-order schedule by intramuscular injection of morphine or cocaine in rhesus monkeys. | three rhesus monkeys lived in primate cages provided with response keys and enclosed in isolation chambers. during experimental sessions on monday, wednesday and friday, the chamber door was closed and every 10th key-pressing response during a 60-minute interval produced a 2-second red light, but had no other programmed consequences (the 10-response fixed-ratio component of the second-order schedule; fr 10). the first fr 10 component completed after the 60-minute interval had elapsed produced a ... | 1976 | 824441 |
| reduced 8-aminoquinoline analogues as potential antimalarial agents. | the synthesis of 1-alkyl-8-(aminoalkylamino)-6-methyl1-1,2,3,4-tetrahydroquinolines, 8-(4'-amino-1'-methylbutylamino)-6-methoxy-1-methyl1-1,2-dihydroquinoline, 5-substituted 8-(4'-amino-1'-methylbutylamino)-1-methyl-1,2-dihydroquinolines, 8-alkylamino-1-(2-n,n-diethylaminoethyl)-6-methoxy-1,2,3,4-tetrahydroquinolines, 1-)2-n,n-diethylaminoethyl)-6-methoxy-1,2,3,4-tetrahydroquinoline, 1-(2-n,n-diethylaminoethyl)-8-(2-n,n-diethylaminoethylamino)-6-methoxy-1,2,3,4-tetrahydroquinoline, and 2-substit ... | 1976 | 824447 |
| chromobacterium violaceum infection in a nonhuman primate (macaca assamensis). | chromobacteriosis caused by chromobacterium violaceum was diagnosed as an assam macaque, macaca assamensis, that died 4 days after receipt of the yerkes primate center, it was received from a primate facility in florida where it has been housed with a group of rhesus monkeys for 5 years. the animal died suddenly without showing any signs of clinical illness. necropsy findings included extensive hepatic necrosis with the formation of multiple large cavitary lesions. foci of necrosis were also fou ... | 1976 | 824500 |
| reduction of sexual interaction in rhesus monkeys by a vaginal action of progesterone. | | 1976 | 824557 |
| effects of diazepam related to social hierarchy in rhesus monkeys. | | 1976 | 824562 |
| the effect of incubation in vitro on the susceptibility of monkey erythrocytes to invasion by plasmodium knowlesi. | rhesus monkey erythrocytes when incubated in vitro under similar conditions to those used for the cultivation of plasmodium knowlesi-infected erythrocytes in vitro, exhibit an increase both in their osmotic fragility and in the activity of their acetylthiocholinesterase. no effect was observed on the catabolism of glucose through the glycolytic pathway or through the primary dehydrogenases of the pentose phosphate pathway. the atp content of normal monkey erythrocytes was also unchanged during i ... | 1976 | 824605 |
| aryl 4-monooxygenase and cytochrome p-450 in the aorta: possible role in atherosclerosis. | aryl 4-monooxygenase [aniline, reduced-flavoprotein:oxygen oxidoreductase (4-hydroxylating); ec 1.14.14.1] activity was searched for and found in homogenates of aorta walls from rabbits, rhesus monkeys, and humans. specific activities were comparable to activities observed in several other extrahepatic tissues of rabbits and monkeys and in epidermal tissues from mice, but were one to two orders of magnitude lower than those observed in corresponding preparations of hepatic tissues. cytochrome p- ... | 1976 | 824648 |
| thyrotropin releasing hormone: antagonism of pentobarbital narcosis in the monkey. | the effect of trh on pentobarbital narcosis in 21 rhesus monkeys was examined. vital signs monitored included respiration rate, heart rate, temperature, sleeping time,and time of reappearance of certain reflexes. blood samples were obtained for pentobarbital assay. two dose schedules for trh administration were used. one group of 6 animals received a single dose of 20 mg/kg 30 min after barbiturate administration, while the other group were received 3 injections of 20 mg/kg spaced at 30, 40 and ... | 1976 | 824652 |
| the effects of testosterone on plasma and platelet monoamine oxidase (mao) an plasma dopamine-beta-hydroxylase (dbh) activities in the male rhesus monkey. | dopamine-beta-hydroxylase (dbh) and monoamine oxidase (mao) in plasma and platelets were studied in male rhesus monkeys to evaluate the effects of changes in endogenous testosterone on the activity of these enzymes. high plasma testosterone concentrations attained at the end of the mating season were associated with relatively low levels of platelet mao activity. when testosterone levels fell, platelet mao increased significantly. mean differences in platelet mao activity between a group of cast ... | 1976 | 824661 |
| experimental trypanosoma cruzi infections in rhesus monkeys. ii. the early chronic phase. | information on the acute and early chronic phases of infection with trypanosoma cruzi in eight rhesus monkeys is reported with particular reference to the pattern of subpatent parasitaemia and serology. xenodiagnosis was superior to animal inoculation and blood culture in its capacity to detect subpatent parasitaemia. each monkey showed an individual, relatively constant pattern of this not related to the nature of the inoculum. levels of indirect fluorescent and indirect haemagglutinating antib ... | 1976 | 824765 |
| [histochemical study of the activity of several enzymes in the process of immunogenesis in monkeys orally infected with viruses of the tick-borne encephalitis complex]. | the activity of succinate dehydrogenase, acid and alkaline phosphatase was studied histochemically in immunocompetent organs of macacus rhesus monkeys orally infected with viruses of the tick-borne encephalitis complex with different biological properties. a gradual increase in the activity of acid phosphatase and succinate dehydrogenase was observed by the 10th--15th day of the experiment followed by its decline to normal by 90 days. the content of alkaline phosphatase in lympoid organs diminis ... | 1976 | 824823 |
| [comparison of the electrophysiologic characteristics of retino-collicular and retino-thalamo-cortical divisions of the visual system of macaca rhesus monkeys]. | in chronic and acute experiments under nembutal anaesthesia, studies have been made on the evoked potentials (ep) elicited by light stimuli in the colliculus superior and in the visual cortex (area 17). it was found that under chronic experiments the ep in the colliculus superior and visual cortex exhibit close (12 +/- 1 and 12 +/- 2 msec. respectively) latent periods; refractory periods determined by paired flashes for both of the parts are equal to 50--70 msec. critical frequency for ep reprod ... | 1976 | 824917 |
| [ultrastructural observations of the retinal pigment epithelial cells following experimental occlusion of the posterior ciliary artery in the rhesus monkey. i. early changes of the damaged retinal pigment epithelial cells (author's transl)]. | | 1976 | 824944 |
| [observations on the corrosion casts of the choriocapillaries of enzyme-induced glaucomatous eye of rhesus monkey (author's transl)]. | | 1976 | 824946 |
| fetal lung lecithin metabolism and the amniotic fluid l/s ratio in rhesus monkey gestations. | the amniotic fluid lecithin/sphingomyelin (l/s) ratio in normal rhesus monkey pregnancies exhibits a distribution through the latter half of gestation similar to that seen in human pregnancies. changes in the synthesis and concentration of lecithin in the fetal lung, measured both in vitro and in vivo, are paralleled by changes in the amniotic fluid l/s ratio. both the amniotic fluid l/s ratio and fetal lung lecithin concentration increase significantly (p less than 0.001) in the final 10 per ce ... | 1976 | 824955 |
| [efferent projections of the caudate nucleus to the cerebral cortex in monkeys]. | the efferent direct connections of the head and tail of the caudate nucleus with the cortex of the ipsilateral hemisphere were studied in adult macaca mulatta. degeneration of endings in the frontal, precentral and postcentral convolutions was found ipsilaterally in sections of the brain impregnanted after wiitanen after destruction of the caudate nucleus. the course of solitary fibres to sites of localization of degenerating endings was followed. as compared with the cat in which caudate-cortic ... | 1976 | 825078 |
| intracerebral oxygen and carbon dioxide tensions in the rhesus monkey. | five rhesus monkeys (m. mulatta) were prepared by surgical placement of a stainless steel implant in the parietal area of the skull. the implant was designed to firmly hold a teflon coated membrane of a medical mass spectrometer in an intracerebral position. animals were consecutively exposed to varying ambient oxygen concentrations from 11% to 21%. intracerebral po2 and pco2 and arterial po2 were all stimultaneously recorded for computer analysis. results indicate an almost linear relationship ... | 1976 | 825090 |
| behavioural sequelae of methaqualone in man and in the monkey (macaca mulatta). | 1 residual effects in man of methaqualone hydrochloride (400 mg) were studied by adaptive tracking and by reaction time. performance was measured at 10 h, 13 h, 16 h, 19 h and 34 h after the overnight ingestion of the drug. there was no evidence of impaired performance on adaptive tracking from 10 h to 19 h, but enhanced performance (p = 0.001) was observed 34 h after ingestion. with reaction time an increase (p = 0.01) was observed 10 h and a decrease (p = 0.05) was observed 19 h after ingestio ... | 1975 | 825133 |
| the development of motor control in the rhesus monkey: evidence concerning the role of corticomotoneuronal connections. | corticospinal fibres terminate in three areas in the spinal grey matter of the rhesus monkey: the nucleus proprius of the dorsal horn, the intermediate zone and directly upon motoneurons, particularly those inervating limb muscles. it was suggested at their earliest discovery that direct corticomotoneuronal (cm) connections might constitute a critical anatomical substrate for the type of fractionated movement exemplified by relatively independent finger movements (rifm). the present study was un ... | 1976 | 825185 |
| evoked unit activity in auditory cortex of monkeys performing a selective attention task. | single-unit responses were recorded from the auditory cortex of rhesus monkeys performing a selective atteintion task which used combined light and sound stimuli. the animals were first trained to push a lever to the left for a noise burst and to the right for a tone burst, and then trained to push left for a left light and right for a right light. subsequently, one of the four possible light and sound stimulus combinations (noise + left light, noise + right light, tone + left light, tone + righ ... | 1976 | 825193 |
| further observations on corticofrontal connections in the rhesus monkey. | the frontal lobe connections of the post-rolandic sensory association areas are investigated; our results indicate that the caudal portion of the superior temporal gyrus (area 22), the lateral peristriate belt (area 18,19), and the superior parietal lobule and the rostralmost portion of the inferior parietal lobule (areas 5 and 7), all project to periarcuate cortex, while the middle portion of area 22, caudal infero-temporal cortex (area 20), and the middle portion of the lower bank of the intra ... | 1976 | 825194 |
| the contribution of the extrahepatic bile ducts to bile formation. | this study was performed to determine the contribution of the extrahepatic bile ducts to bile flow in the rhesus monkey. bile flow from the two sides of the liver was divided. the major extrahepatic bile ducts remained connected to one side of the liver only. bile flow, and the concentrations of [14c]erythritol, bicarbonate, bile acid, and bilirubin in bile samples from the two sides of the liver, in the fed state were measured and compared. an estimate of the net flow from the extrahepatic duct ... | 1976 | 825208 |
| intracarotid bcnu (nsc-409962): a toxicity study in six rhesus monkeys. | intracarotid artery (ica) bcnu was given at doses of 1-20 mg/kg/week for 4 weeks in six rhesus monkeys. vascular, neurologic, and ophthalmic toxic effects were minor. the monkey receiving a dose of 15 mg/kg had transient left hemiparesis and slowing in her electroencephalogram which cleared 1 week after the third ica infusion of bcnu. at autopsy no vascular, neural, or ophthalmic lesions were found. at doses of 20 mg/kg for two injections, one monkey developed fatty metamorphosis of the liver an ... | 1976 | 825222 |
| metabolic clearance and production rates of progesterone in non-pregnant and pregnant baboons (papio papio). | the metabolic clearance rate (mcr) of progesterone was examined in the baboon to determine whether the increased serum progesterone concentrations during gestation result from increased production or decreased clearance. mcr was determined by constant infusion of [3h]progesterone in 6 non-pregnant baboons and 13 pregnant animals, between 58 and 175 days gestation. progesterone mcr (mean+/-se) was significantly greater in pregnant (1316+/-105 1/day, p less than 0.025; 87.3 +/- 6.2 1/day/kg, p les ... | 1976 | 825366 |
| effect of schistosoma mansoni on plasma cholinesterase activity in rhesus monkeys. | | 1976 | 825382 |
| peristalsis in smooth muscle esophagus after transection and bolus deviation. | the importance of the continuity of the muscle coat and of the presence of an intraluminal bolus for the peristaltic performance of the rhesus monkey esophagus was studied. transection and reanastomosis with muscle-to-muscle contact in the striated muscle part of the esophagus did not interfere with the progression of primary peristaltic contractions. however, when the transection with reanastomosis was performed in the smooth muscle part of the gullet the peristaltic progression of the deglutit ... | 1976 | 825409 |
| effect of bile acid synthesis rate on cholesterol secretion rate in the steady state. | in order to discover the effect of bile acid synthesis on cholesterol secretion into the bile, 7 rhesus monkeys were studied at various stable interruptions of the enterohepatic circulation of bile acids. in 4 animals, 2.5 and 7.5% interruptions were compared; 2.5 and 15% interruptions were compared in 5 animals. there was a significant decrease in the cholesterol secretion rate, 0.048 mmoles per 24 hr +/- 0.016 (sd), and a significant increase in bile acid synthesis rate, 0.62 mmoles per 24 hr ... | 1976 | 825410 |
| experimental studies on the pathogensis of temporal lobe epilepsy. | in 12 rhesus monkeys the injection of alumina cream into the temporal cortex, amygdala or hippocampus induced seizures after a latent period of six weeks to three months. clinically the attacks are characterized by an arrest of movement, staring, unresponsiveness to most stimuli, wandering conjugate eye movements, automatisms, twitching of the contraleteral ear and less commonly commonly vocalization, chewing, hiccoughing, vomiting, adversive head movements and twitching of the face. the spiking ... | 1976 | 825423 |
| a randomized technique of constant-pressure infusion. | a population study of measured inflow values of eyes of a group of adult male rhesus monkeys was done with a randomized technique of constant-pressure infusion. each eye was presented with a sequence of 18 4-minute runs, consisting of three infusion runs for each of six pressures, in which the order of appearance of a given pressure had been randomized. a statistical analysis of the results indicates that only the independent variables of infusion pressure, type of anesthetic, and position in th ... | 1976 | 825480 |
| lung mechanics following antigen challenge of ascaris suum-sensitive rhesus monkeys. | pulmonary resistance (rl) breathing air and a helium-oxygen mixture (he-o2) dynamic compliance (cdyn), respiratory frequency (f), subdivisions of lung volume, and static deflation pressure-volume (pv) curves were measured before and after bronchial challenge with ascaris suum antigen in six rhesus monkeys with varying skin reactivity to this antigen. the animals were lightly anesthetized with pentobarbital sodium, intubated, and studied in a volume displacement body plethysmograph, transpulmonar ... | 1976 | 825504 |
| substantia nigra lesions in rhesus monkeys injected with attenuated polioviruses. | | 1976 | 825516 |
| lack of in vivo transformation of human growth hormone to its "activated" isohormones in peripheral tissues of the rhesus monkey. | human growth hormone (hgh) b can be transformed to its biologically more active isohormones c, d and e by limited proteolysis with plasmin in vitro, but the physiological significance of this observation is not known. the possible occurrence of such an "activation process" in peripheral tissues was investigated in the rhesus monkey. radioiodinated hgh (b, c) or isolated hgh-b were injected intravenously into 4 rhesus monkeys and blood samples were drawn at frequent intervals. analysis of circula ... | 1976 | 825526 |
| effect of thyrotropin-releasing hormone on secretion of thyrotropin, prolactin, thyroxine, and triiodothyronine in pregnant and fetal rhesus monkeys. | the effect of thyrotropin-releasing hormone (trh) on the pituitary-thyroid axis and on prolactin secretion was studied in pregnant rhesus monkeys during the latter period of gestation and in non-pregnant female controls. the baseline plasma concentrations of tsh, t3, t4, and prolactin (prl) of pregnant monkeys did not differ from those of non-pregnant monkeys. after administration of trh, plasma prolactin rose to higher levels in pregnant monkeys than in non-pregnant monkeys whereas there was a ... | 1976 | 825527 |
| autoradiographic localization of hormone-concentrating cells in the brain of the female rhesus monkey. | with autoradiographic procedures, cells which bind 3h-estradiol were found in preoptic, hypothalamic and limbic structures in the brains of ovariectomized, adult female rhesus monkeys. estrogen-binding cells were seen in the medial preoptic area, medial anterior hypothalamus, ventromedial nucleus, and especially heavy labelling was seen throughout the extent of the arcuate (infundibular) nucleus of the hypothalamus. in limbic structures, cells in the bed nucleus of the stria terminalis and in t ... | 1976 | 825546 |
| attempted infection of the rhesus monkey (macaca mulatta) with the british horse strain of echinococcus granulosus. | | 1976 | 825551 |
| a comparison of immunologic asthma to two types of cholinergic respiratory responses in the rhesus monkey. | rhesus monkeys were used to characterize the respiratory response (rr) to aerosolized physostigmine (phy) and compare the response to the acute, reagin-mediated rr and the carbachol response. in the latter two responses, there are characteristic increases in frequency of respiration (f), pulmonary resistance (pr), and decreases in peak expiratory flow rate (pefr), tidal volume (tv), and dynamic compliance (c). in contrast, a phy rr characteristically shows no change in tv and f. the phy rr is in ... | 1976 | 825598 |
| cholesterol metabolism in groups of rhesus monkeys with high or low response of serum cholesterol to an atherogenic diet. | cholesterol metabolism has been studied in two groups of five rhesus monkeys each that were selected from the upper and lower sextile in the distribution of serum cholesterol concentration while being fed an atherogenic diet. this diet consisted of a basal commercial monkey food supplemented with saturated fat and cholesterol. to determine differences that might be related to the difference in serum cholesterol concentration, parameters of whole body cholesterol metabolism were measured while th ... | 1976 | 825605 |
| response of unmyelinated (c) polymodal nociceptors to thermal stimuli applied to monkey's face. | 1. the response of c polymodal nociceptors to thermal and mechanical stimuli applied to the monkey's face was recorded extracellulary in the trigeminal ganglion in rhesus monkeys anesthetized with sodium pentobarbital. conduction velocities, determined from electrical stimulation of receptive fields (rfs), were in the range for unmyelinated c fibers (mean=0.82 m/s, n=20; sd=+/-0.17). with two exceptions cutaneous rfs were single spots (median=2 mm2; n=37) and usually were identical for thermal a ... | 1976 | 825619 |
| effects of cerebellar lesions on saccadic eye movements. | 1. areas of cerebellar cortex related to saccadic eye movements were ablated in three macaca mulatta monkeys trained to fixate visual targets. there followed a postoperative dysmetria of saccadic eye movements which appeared to be the result of an impairment specifically within the saccadic system. 2. convergent evidence from two experimental paradigms indicated that the saccadic deficit was a function of the position of the eye in the orbit and did not involve retinal error processing. 3. the p ... | 1976 | 825620 |
| quantitative studies of single-cell properties in monkey striate cortex. i. spatiotemporal organization of receptive fields. | 1. the properties of single cells in striate cortex of the rhesus monkey, representing the visual field 2 degrees -5 degrees from the fovea, were examined quantitatively with stationary and moving stimuli. three distinct classes of cells were identified: s type, cx type, and t type. 2. s-type cells were defined as those oriented cells which to the optimal direction of movement in their receptive fields exhibited one or more spatially separate subfields within each of which a response was obtaine ... | 1976 | 825621 |
| quantitative studies of single-cell properties in monkey striate cortex. ii. orientation specificity and ocular dominance. | 1. quantitative analyses of orientation specificity and ocular dominance were carried out in striate cortex of the rhesus monkey. 2. sharpness of orientation selectivity was greater for simple (s type) than for complex (cx type) cells. cx-type cells became more broadly tuned in the deeper cortical layers: s-type cells were equally well tuned throughout the cortex. 3. sharpness of orientation selectivity for s-type cells was similar at all retinal eccentricities studied (0 degrees - 20 degrees fr ... | 1976 | 825622 |
| a clinical and histologic study of healing following the excisional new attachment procedure in rhesus monkeys. | experimental suprabony periodontal pockets were established around the incisors of rhesus monkeys and subsequently were treated by the excisional new attachment procedure. healing was evaluated clinically and histologically for up to 6 months. clinical examinations demonstrated an overall mean pocket depth reduction from 5.02 mm to 2.82 mm, of which 0.57 mm was recession and 1.59 mm (73.6%) was clinical new attachment. histologic evaluation of experimental sites consistently revealed a long, thi ... | 1976 | 825631 |
| effect of estrogens and progestins on the cervix uteri. | high doses of estrogen may increase the occurrence of cervical cancer in mice but not in the rat, dog, or rhesus monkey. available data do not demonstrate that estrogens increase the frequency of cervical cancer in women. thus, studies in the mouse did not predict correctly for women. the effects of progestins and oral contraceptives on the cervix of various species are also reviewed. | 1976 | 825654 |
| conditioned behavioral and physiological changes associated with injections of a narcotic antagonist in morphine-dependent monkeys. | environmental stimuli which are repeatedly associated with the nalorphine-induced withdrawal syndrome in morphine-dependent monkeys acquire the ability to produce a variety of conditioned behavioral and physiological responses. morphine-dependent rhesus monkeys were studied under a fixed-ratio schedule where every tenth lever press produced a food pellet. after several pairings of a stimulus (light or tone) with intravenous injection of a dose of nalorphine which produced an immediate and severe ... | 1976 | 825815 |
| preparation and immunosuppressive potency of equine anti-human thymocyte membrane igg. | anti-human thymocyte cell membrane antibody prepared by hyperimmunization of the horse produced an antiserum capable of prolonging skin allografts in the rhesus monkey for an average of 26 days. lymphocyte depletion was present in paracortical areas of mesenteric lymph nodes of these animals after 28 days of treatment; the intravenous administration was tolerated without ill effects. immunofluorescent studies identified both broad specificity antibodies reacting with numerous human cell types as ... | 1976 | 825846 |
| influence of suckling on gonadotropin secretion in the postpartum rhesus monkey. | | 1976 | 825871 |
| the electroencephalographic effects of long term cocaine administration to rhesus monkeys. | | 1976 | 825875 |
| short-term memory in the rhesus monkey: disruption from the anti-cholinergic scopolamine. | two separate experiments were conducted to evaluate the effects of the anti-cholinergic scopolamine on primate visual discrimination and short-term memory (stm). in the first experiment it was shown that relatively mild doses of scopolamine severly impaired visual discrimination performance, even though the test procedure provided strong stimulus control. this deficit in visual discrimination suggested that previous research which used the delayed matching to sample procedure (dms) to evaluate t ... | 1976 | 825880 |
| the role of reinforcement loss in tolerance to chronic delta9-tetrahydrocannabinol effects on operant behavior of rhesus monkeys. | two monkeys were trained on a multiple fixed-interval (fi) 120 sec, differential reinforcement of low rate (drl) 120 sec schedule of food reinforcement for lever pressing in which the two schedules, each correlated with a distinctive cue, alternated throughout an experimental session. under chronic daily treatment with delta-9-tetrahydrocannabinol in a dose of 7 mg per os (1 mg/kg), for 40 consecutive days, responding increased in both schedules. performance on the drl schedule was affected les ... | 1976 | 825882 |
| dyskinesias in monkeys: interaction of methamphetamine with prior methadone treatment. | rhesus monkeys with a history of drinking methadone, but presently drug-free, were injected with low doses of methamphetamine (ma). they immediately developed oral dyskinesias resembling the symptoms of tardive dyskinesia in humans, a condition resulting from chronic blockade of striatal dopamine receptors by neuroleptics. nine of 11 control monkeys failed to develop dyskinesias during prolonged ma administration. a stressful stimulus intensified the ma-elicited oral dyskinesias, an effect analo ... | 1976 | 825885 |
| sexual behavior of castrated male rhesus monkeys treated with 19-hydroxytestosterone. | | 1976 | 825889 |
| sequential and single-stage lesions of posterior association cortex in rhesus monkeys. | | 1976 | 825893 |
| ultradian rhythms of solitary and social behavior in rhesus monkeys. | | 1976 | 825894 |
| endocrine responses to electric shock and avoidance conditioning in the rhesus monkey: cortisol and growth hormone. | | 1976 | 825896 |