| bacteremia in conjunction with endodontic therapy. | this study characterizes oral microorganisms believed to have spread from the root canal into the blood stream during and after endodontic therapy of teeth with asymptomatic apical periodontitis. microbiological samples were taken under aseptic conditions from the root canal of 26 single-rooted teeth in 26 patients. in the endodontic treatment of 13 of the patients (group 1), the first 3 reamers, sizes 15, 20 and 25, were used to a level 2 mm beyond the apical foramen. in the other 13 patients ( ... | 1995 | 7641631 |
| regulation of hepatic macrophage function by oral administration of xiao-chai-hu-tang (sho-saiko-to, tj-9) in rats. | the effect of xiao-chai-hu-tang (sho-saiko-to, tj-9), the extract of a mixture of 7 herbs, on hepatic macrophage function was studied using rats. hepatic macrophages were activated by injection of corynebacterium parvum or 70% partial hepatectomy. oral administration of tj-9 for 3 weeks did not affect the ability of these macrophages to produce superoxide anions evaluated in situ by liver perfusion with nitro blue tetrazolium (nbt) and phorbol myristate acetate (pma). however, the similar admini ... | 1995 | 7650948 |
| [comparative in vitro activity of ampicillin, cefoperazone and their combinations with sulbactam, as well as that of other antibiotics against anaerobic organisms]. | susceptibility of 180 strains of anaerobic organisms to ampicillin, cefoperazone and their combinations with sulbactam, as well as that to cefoxitin, imipenem and metronidazole was studied with the method of serial microdilutions. 100 per cent of the strains was susceptible to the ampicillin + cefoperazone combination. only 1 strain of bacteroides fragilis was resistant to imipenem. 73.4 and 57.8 per cent of the b. fragilis strains were susceptible to cefoxitin and cefoperazone respectively. no ... | 1995 | 7654095 |
| [hypertrophic cranial pachymeningitis with propionibacterium acnes detected by dural biopsy]. | a 30-year-old woman experienced recurrent dull headache and frequent partial motor seizure (jacksonian type) that marched from right fingers. this motor seizure was uncontrollable with ordinary anticonvulsant therapy. cerebrospinal fluid showed mild pleocytosis. cranial ct examination was unremarkable, but mri revealed thickened dural lesion on the left fronto-parietal site, giving diagnosis of hypertrophic cranial pachymeningitis. dural biopsy showed nonspecific chronic granulomatous state with ... | 1995 | 7664523 |
| changes in neuronal mrnas induced by a local inflammatory reaction. | injection of corynebacterium parvum into the rat dorsal root ganglion has previously been shown to cause an inflammatory reaction dominated by macrophages and to enhance regeneration of the central axons of primary sensory neurons. here, neuronal mrnas that are modified by nerve transection were analyzed by in situ hybridization following injection of c. parvum into the dorsal root ganglion. neuronal concentrations of mrnas for the growth-associated protein (gap-43) and the immediate early gene ... | 1995 | 7674381 |
| endoscopic treatment of acute frontal sinusitis: indications and limitations. | | 1995 | 7675495 |
| increased endogenous n-nitrosamine and nitrate formation by induction of nitric oxide synthase in rats with acute hepatic injury caused by propionibacterium acnes and lipopolysaccharide administration. | in rats treated i.v. with heat-killed propionibacterium acnes (100 mg/kg body wt), followed 5 days later by an i.v. dose of escherichia coli lipopolysaccharide (lps, 1 mg/kg body wt), acute hepatic cell necrosis was accompanied by significant induction of nitric oxide (no) synthase activity in the liver. endogenous nitrosation of thiazolidine 4-carboxylic acid (tca, 50 mumol/rat) administered by three different routes (i.v., i.p. and p.o.) 5 h after lps injection to the p. acnes-treated rats was ... | 1993 | 7678786 |
| immunohistochemical localization of an inducible form of nitric oxide synthase in various organs of rats treated with propionibacterium acnes and lipopolysaccharide. | immunohistochemical localization of an endotoxin-inducible form of nitric oxide synthase was examined using rabbit polyclonal antibody against the enzyme purified from rat liver. in rats treated with propionibacterium acnes and lipopolysaccharide, immunostaining was observed in macrophages, occasional lymphocytes, neutrophils and eosinophils in red pulp of spleen, kupffer cells, endothelial cells and hepatocytes in liver, alveolar macrophages in lung, macrophages and endothelial cells in adrenal ... | 1993 | 7686760 |
| nitric oxide synthase expression is induced in hepatocytes in vivo during hepatic inflammation. | nitric oxide (no.) is a short-lived biologic mediator produced by the enzyme no. synthase (nos) which exists in constitutive and inducible isoforms. previously, we have shown that hepatocytes express an inducible nos in vitro following exposure to the combination of lipopolysaccharide and inflammatory cytokines. the purpose of the present study is to characterize the induction of nos in vivo in rat hepatocytes during chronic hepatic inflammation triggered by corynebacterium parvum injection and ... | 1993 | 7692140 |
| molecular cloning of a cdna encoding an inducible calmodulin-dependent nitric-oxide synthase from rat liver and its expression in cos 1 cells. | calmodulin-dependent nitric-oxide synthase, with an apparent molecular mass of 125 kda, was induced in the liver of rats treated with propionibacterium acnes and escherichia coli lipopolysaccharide. clones were isolated from a cdna library obtained from induced rat liver using oligonucleotide probes which were synthesized based on the amino acid sequences of peptides of the purified enzyme. four overlapping cdna clones for a 3.8-kbp region were isolated and the nucleotide sequences were determin ... | 1993 | 7693462 |
| chronic sclerosing osteomyelitis of the mandible in monozygotic twins. | identical female twins with chronic sclerosing osteomyelitis of the mandible are presented. the diagnoses of both at the age of 12 years were based on typical history, and on clinical, radiographic, and histologic findings. high concentrations of iga and igg were detected in the serum of both patients, but deviations were not observed in other immunologic variables. the normally commensal organism, propionibacterium acnes grew from a bone biopsy specimen from the mandible of one twin. no oral fo ... | 1994 | 7699275 |
| preventive effect of taraxasteryl acetate from inula britannica subsp. japonica on experimental hepatitis in vivo. | the survival rate for acute hepatic failure induced by propionibacterium acnes and lipopolysaccharide (lps) was increased when a hot water extract from the flowers of inula britannica l. subsp. japonica kitam. was injected into the experimental hepatitis mice, and anti-hepatitis substances could be extracted with chcl3. the chcl3 extract from i.britannica was fractionated and anti-hepatitis fractions ib-3-2 and ib-3-3 were obtained. ib-3-3 had the most potent anti-hepatitis activity among the fr ... | 1995 | 7700992 |
| dibutyryl cyclic amp protects corynebacterium parvum-treated mice against lipopolysaccharide-induced lethal toxicity. | the effects of dibutyryl cyclic amp (dbcamp) on the lethal toxicity of lipopolysaccharide (lps) were investigated in mice made hypersensitive to lps by administration with corynebacterium parvum (c. parvum). the peritoneal macrophages in c. parvum-treated mice released a conspicuous level of tnf alpha in response to lps in vitro. these macrophages exhibited much higher susceptibility to lps-induced cytotoxicity than with resident or peptone-induced macrophages. pretreatment of the c. parvum-indu ... | 1995 | 7704897 |
| [treatment of malignant pleural effusion by percutaneous catheter drainage and chemical pleurodesis]. | from june 1989 to december 1991, 93 patients affected by malignant pleural effusion (mpe) were treated as out patients using a ultrasound (us) guided catheter drainage (10f percuflex pig-tail catheter-medi-tech@(ptc) and chemical pleurodesis. the ptc was positioned when the mpe had been diagnosed by x-ray and all the patients had undergone some thoracentesis (mean 3.2, range 2-6). we started a chemical pleurodesis when the mpe was inferior to 100cc/day injecting epidoxorubicin (edx 30 mg/mq) in ... | 1994 | 7708227 |
| efficacy and safety of gentamicin and streptomycin in optisol-gs, a preservation medium for donor corneas. | increasing reports of gentamicin-resistant bacteria contaminating donor corneas and causing endophthalmitis have indicated that preservation of corneal storage media with 100 micrograms/ml of gentamicin alone needs reevaluation. we investigated the stability and possible cytotoxicity of streptomycin as a supplement to gentamicin in optisol corneal storage medium. the combination of gentamicin and streptomycin in optisol solution was stable at room temperature for at least 4 weeks and inhibited t ... | 1995 | 7712737 |
| delayed infections following posterior spinal instrumentation for the treatment of idiopathic scoliosis. | ten patients who had been managed with posterior spinal arthrodesis and texas scottish rite hospital instrumentation because of idiopathic scoliosis had a delayed deep wound infection at an average of twenty-five months after the operation. the signs of infection included spontaneous drainage in eight patients and fluctuance in two patients. in addition, six patients--including five of the eight who had drainage--had mild pain in the back. the average erythrocyte sedimentation rate was thirty-ni ... | 1995 | 7713968 |
| intrapleural corynebacterium parvum for recurrent malignant pleural effusions. | twenty-two consecutive patients with malignant pleural effusions (mpe) were treated with intrapleural corynebacterium parvum (cbp) associated with parenteral methylprednisolone (mp) to determine its effectiveness and the frequency and nature of adverse reactions. after thoracentesis, 7 mg of cbp (coparvax wellcome) in 20 ml of saline were injected into the pleural cavity. on the day of treatment, the patients were given 1 mg/kg i.m. of mp 30 min before thoracentesis. the effectiveness of pleurod ... | 1995 | 7716350 |
| expression of hepatocyte growth factor and transforming growth factor beta 1 mrna in p. acnes and lipopolysaccharide-treated rats. | hepatocyte growth factor (hgf), a potent hepatocyte mitogen in vitro, triggers hepatocyte regeneration after partial hepatectomy and acute liver cell necrosis induced by chemicals. in contrast, transforming growth factor beta 1 inhibits hepatocyte proliferation in vitro and suppresses liver regeneration in vivo. we assessed the expression of hgf and tgf beta 1 mrna in an endotoxin-related hepatic cell necrosis model. intravenous injection of gram-negative lipopolysaccharide (lps) into rats previ ... | 1995 | 7719414 |
| mechanism for macrophage activation against corynebacterium parvum--participation of t cells and its lymphokines. | it is well known that corynebacterium parvum activates macrophages to produce tumor necrosis factor (tnf). it is suspected that the activation of macrophages by c. parvum requires t-cell participation. the purpose of this study was to confirm that t cells participate in the activation of macrophages by c. parvum. tnf production in vitro from the spleen cells of balb/c(-)+/+ mice was abrogated completely by the pre-treatment of spleen cells with anti-ia antiserum and complement, indicating that i ... | 1994 | 7723692 |
| the influence of propionibacterium acnes (corynebacterium parvum) fractions on immune response in vivo. | bacterin of propionibacterium acnes (corynebacterium parvum), its cellular fractions (lipids, fractions obtained by mechanical disruption and differential centrifugation, by phenol-water and pyridine extractions), and a polysaccharide from culture filtrate were prepared and tested in mice. the activation of res by splenomegaly and hepatomegaly, prevention of listerial infection, prevention of the lethal effect of sarcoma 180, and depression of liver microsomal cytochrome p-450 were employed. the ... | 1994 | 7727904 |
| (e)-3-tridecen-2-one, an antibiotic from the interdigital glands of black-tailed deer odocoileus hemionus columbianus. | (e)-3-tridecen-2-one, the major volatile component of interdigital gland extracts from the black-tailed deer, odocoileus hemionus columbianus, inhibited the growth of gram-positive bacteria and fungi. the bacteria, propionibacterium acnes, and the fungi, trichophyton mentagrophytes had a minimum inhibitory concentration (mic) of 12.5 micrograms/ml and 25 micrograms/ml, respectively. | 1995 | 7729504 |
| adherence of bacteria to intraocular lenses: a prospective study. | the study was designed to investigate the bacterial flora of the operating field during routine cataract surgery and the source of intraocular lens contamination during the surgery. | 1995 | 7742281 |
| [bone and joint infections due to unusual pathogens]. | between 1989 and 1993, 7 patients--2 men and 5 women from 19 to 70 years of age--with osteomyelitis due to an unusual organism were observed. 3 cases with salmonella typhimurium and one at a time with escherichia coli, peptostreptococcus, propionibacterium acnes and pasteurella multocida. 5 patients were treated operative accompanied with antibiotics and 1 without operation. 1 patient declined the indicated surgical therapy. the outcome were total healing in 3 cases, healing with ankylosis of th ... | 1995 | 7754663 |
| establishment of a t cell-dependent nude mouse liver injury model induced by propionibacterium acnes and lps. | normal icr mice developed severe liver injury when they were given intravenous injections of propionibacterium acnes and lipopolysaccharide (lps) with a 7 day interval. in contrast, t cell-deficient icr nude mice were resistant to p. acnes and lps-induced liver injury. however, athymic icr nude mice, which were treated with cell transfer of normal icr mouse spleen cells (10(8) cells) or icr mouse nylon-wool passed splenic t-enriched cells (over 10(7) cells), showed severe liver injury as assesse ... | 1995 | 7769241 |
| the effect of e3330 on active oxygen generation by isolated hepatic macrophages in rats. | | 1995 | 7773361 |
| anandamide inhibits macrophage-mediated killing of tumor necrosis factor-sensitive cells. | anandamide (arachidonoylethanolamide) was shown to inhibit macrophage-mediated killing of tumor necrosis factor-sensitive murine l929 fibroblasts. scanning electron microscopy (sem) demonstrated that l929 cells, co-cultured with propionibacterium acnes (p. acnes)-activated peritoneal macrophages from mice treated with vehicle, were either disrupted or had surface abnormalities and numerous punctate lesions. in contrast, l929 cells co-cultured with macrophages from mice receiving p. acnes in conc ... | 1995 | 7776833 |
| some biochemical characteristics of the early phase of immunomodulation. | the study estimates some biochemical changes of chosen immunological and biochemical parameters after intraperitoneal application of a) immunomodulators of microbial origin--propionibacterium acnes and geotrichum candidum, b) chemical substances--indomethacin and phenobarbital. the estimation was concentrated above all to the changes of chemiluminiscence, phagocytic activities, the amount of camp in peritoneal macrophages, the amount of liver cytochrome p-450 and camp in the liver, spleen and th ... | 1994 | 7778504 |
| in vitro activity of dmg-mino and dmg-dm dot, two new glycylcyclines, against anaerobic bacteria. | the in vitro activity of dmg-mino and dmg-dm dot against 350 anaerobic bacterial strains including anaerobic cocci, propionibacterium acnes, clostridium perfringens, clostridium difficile, bacteroides fragilis, other bacteroides species and fusobacteria was determined by the agar dilution method. their activity was compared with that of minocycline, doxycycline, piperacillin, cefoxitin, imipenem, clindamycin and metronidazole. dmg-mino and dmg-dm dot and imipenem were the most active agents test ... | 1993 | 7802861 |
| the role of adjuvant therapy in melanoma management. | adequate wide excision of a primary cutaneous melanoma is associated with a 10-year cure rate of 85% when the tumor's depth is less than 1.5 mm (american joint committee on cancer [ajcc] stage i). however, 50% of patients with deep (> 4 mm) primary melanomas, 60-85% of those with regional lymph node metastases (ajcc stage iii), and 95% of those with metastases to distant sites (ajcc stage iv) will experience recurrence, which is associated with a dismal prognosis. adjuvant therapy of melanoma as ... | 1995 | 7805001 |
| molecular and structural requirements of a lipoteichoic acid from enterococcus hirae atcc 9790 for cytokine-inducing, antitumor, and antigenic activities. | comparison was made between the immunobiological and antigenic properties of two lipoteichoic acid (lta) fractions (lta-1 and -2) from enterococcus hirae atcc 9790, their glycolipid portions, and synthetic compounds partially mimicking the above bacterial products. the more lipophilic lta-2 fraction was capable of inducing serum tumor necrosis factor alpha and interleukin-6 in muramyldipeptide-primed mice and serum gamma interferon in those primed with propionibacterium acnes. the lta-2 fraction ... | 1995 | 7806384 |
| corynebacterium parvum pleurodesis. | | 1995 | 7813299 |
| efficacy of dry cow therapy and a propionibacterium acnes product in herds with low somatic cell count. | dry cow therapy and a propionibaterium acnes product were evaluated in four commercial herds with low scc. cows were randomly assigned within herds to treatment groups of approximately 90 cows receiving dry cow therapy, p. acnes, dry cow therapy plus p. acnes, or no treatment in a factorial arrangement. each lactating quarter of cows that received dry cow therapy was infused via the teat duct with 300 mg of cephaprin at drying off. cows that received p. acnes were infused intravenously with .4 m ... | 1994 | 7814709 |
| use of prostaglandin i2 analog in treatment of massive hepatic necrosis associated with endothelial cell injury and diffuse sinusoidal fibrin deposition. | endothelial cell damage causes massive hepatic necrosis as a result of fibrin deposition in the hepatic sinusoids. when a stable analog of prostaglandin i2, beraprost sodium, was administered to rats given either dimethylnitrosamine, carbon tetrachloride, or endotoxin following corynebacterium parvum administration, the hepatic necrosis produced in each was attenuated, but to a greater extent in the dimethylnitrosamine and endotoxin/corynebacterium parvum models, where fibrin deposition in the h ... | 1995 | 7821117 |
| [disseminated propionibacterium acnes cutaneous infection in a neutropenic patient]. | | 1994 | 7824482 |
| disruption of the transmembrane ph gradient--a possible mechanism for the antibacterial action of azelaic acid in propionibacterium acnes and staphylococcus epidermidis. | the effect of the topical acne treatment azelaic acid on the transmembrane proton gradient (delta ph) of propionibacterium acnes and staphylococcus epidermidis was studied in vitro at external ph values found on human skin (ph 4.0-6.0). bacteria were grown in defined media using continuous culture and delta ph was estimated by measuring the accumulation of [14c] benzoic by the cells using flow dialysis. in both p. acnes and s. epidermidis the addition of 30 mm azelaic acid and the membrane activ ... | 1994 | 7829407 |
| herpes simplex virus type 1 replication and il-1 beta gene expression in mouse peritoneal macrophages activated in vivo by an attenuated salmonella typhimurium vaccine or corynebacterium parvum. | activated macrophages (m phi) from mice given salmonella typhimurium or corynebacterium parvum were compared with resident peritoneal macrophages at the molecular level for permissiveness for herpes simplex virus type 1 (hsv-1) replication and for expression of interleukin-1 beta (il-1 beta). peritoneal macrophages were harvested from mice injected 7 days previously with live, avirulent s. typhimurium (sal-pm phi) or heat-killed c. parvum (cp-pm phi) and infected with hsv-1 in vitro. both sal-pm ... | 1994 | 7830526 |
| targets of nitric oxide in a mouse model of liver inflammation by corynebacterium parvum. | treatment of mice with corynebacterium parvum induces chronic inflammation. this treatment followed by an injection of lipopolysaccharide (lps) produces hepatic necrosis and death. we examined liver tissue by using electron paramagnetic resonance (epr) spectroscopy and found that, in addition to the previously reported nonheme nitrosyl complexes, heme nitrosyl complexes were also formed. hemoglobin nitrosyl complexes measured in the whole blood of mice treated with c. parvum were not increased a ... | 1995 | 7840629 |
| bronchopneumonia caused by propionibacterium acnes. | propionibacterium acnes was identified as the pathogen in a case of subacute lung infection by examination of an open lung biopsy specimen. the patient was a 65-year-old male with exacerbation of chronic lung disease. the organism was isolated in pure culture and was present in large numbers on gram stain. histological examination demonstrated active interstitial fibrosis; macrophages laden with propionibacterium acnes antigen were revealed using a peroxidase-antiperoxidase stain. this is the fi ... | 1994 | 7843179 |
| partial characterization of the enhanced survival of female nzb/w mice treated with lithium chloride. | previous investigations have indicated that initiation of licl treatment (4 mg/day) of female nzb/w mice at 10 weeks of age led to enhanced survival of 50% of the mice to > 11 months of age (lithium, 3, 61-67, 1992). the present results indicate that this enhancement of survival is dose dependent in that 2 mg 7licl/day was less effective than 4 mg 7licl/day. daily treatment of groups of mice with 2 or 4 mg licl per day starting at 8 weeks of age led to the survival of 40% and 70%, respectively, ... | 1994 | 7843854 |
| pleurodesis with doxycycline or corynebacterium parvum in malignant pleural effusion. | pleurodesis with doxycycline (100 mg and 600 mg) and corynebacterium parvum (1 mg and 7 mg) were compared in 41 patients with malignant effusion. to evaluate the mechanisms, pleural fluid ph, leukocytes, granulocytes, interleukin-6 (il-6) and serum il-6, as well as c-reactive protein (crp) were measured before and on 2 consecutive days after treatment. corynebacterium parvum produced a greater acute-phase response measured with fever, serum crp and il-6 than doxycycline. however, no change in pl ... | 1995 | 7865226 |
| delayed hypersensitivity to propionibacterium acnes in patients with severe nodular acne and acne fulminans. | increased hypersensitivity reactions to propionibacterium acnes may be involved in the pathogenesis of severe acne. | 1994 | 7873817 |
| propionibacterium acnes as a cause of aggressive aortic valve endocarditis and importance of tissue grinding: case report and review. | a case of prosthetic valve endocarditis with propionibacterium acnes is described. the diagnosis was documented by histology and isolation of p. acnes from both blood and anulus tissue. grinding of the tissue, which was first omitted to avoid contamination, was indispensable for cultivating the agent. the literature for p. acnes endocarditis is reviewed. | 1994 | 7883897 |
| antibiotic prophylaxis in corneal storage media. | | 1994 | 7886863 |
| application of corynebacterium parvum lysate into the brain of rats--morphological study. | the authors investigated the influence of application of the corynebacterium parvum lysate (cpl) into the brain of rats with aim to define the resulting morphological changes. variable amount of the cpl (0.1, 0.35, 0.7 mg) was injected under stereotactic control into frontal lobe of the left cerebral hemisphere. morphological changes were studied after intervals of 3, 7, 14, and 30 days respectively. cpl lead to inflammatory and reparative changes in direct relations to the administered dosage. ... | 1993 | 7887199 |
| biochemical aspects of immunomodulation by propionibacterium acnes. | the present paper deals with the effect of indomethacin and/or propionibacterium acnes (pa) on the cytochrome p-450 content in liver microsomal fraction, free fatty acids and lipase concentration in serum with respect to the phagocytic activities of monocytomacrophage system, changes in weight of the spleen and liver, survival after ld100 of klebsiella pneumoniae, and histology of the spleen and liver. the results obtained indicate that indo acts as an inhibitor of cytochrome p-450 and at the sa ... | 1993 | 7887204 |
| granulomatous infection due to propionibacterium acnes mimicking malignant disease. | | 1994 | 7889976 |
| in vitro modulation of keratinocyte-derived interleukin-1 alpha (il-1 alpha) and peripheral blood mononuclear cell-derived il-1 beta release in response to cutaneous commensal microorganisms. | the ability of a range of skin commensal microorganisms to modulate interleukin-1 (il-1) release by cultured human keratinocytes and peripheral blood mononuclear cells (pbmcs) was investigated by a combination of enzyme-linked immunosorbent assays and bioassays. three fractions (formaldehyde-treated whole cells, culture supernatants, and cellular fractions) were prepared from propionibacterium acnes, propionibacterium granulosum, staphylococcus epidermidis, staphylococcus capitis, staphylococcus ... | 1995 | 7890376 |
| propionibacterium: resistance of acne to antibiotics. | | 1995 | 7891939 |
| persistent endophthalmitis after intravitreal antimicrobial therapy. | to assess the frequency of persistent infection after injection of intravitreal antimicrobials as therapy for endophthalmitis and to determine if persistent infection influences the final visual outcome after treatment. | 1995 | 7891974 |
| the correlation of kampo formulations and their ingredients on anti-bacterial activities against propionibacterium acnes. | the correlation between the susceptibilities of propionibacterium acnes strains to two kampo formulations and these to their ingredients (kampo crude drugs) was examined. two out of 19 kampo crude drugs, coptidis rhizoma (cr) and phellodendri cortex (pc), inhibited the growth of p. acnes significantly. the patterns of distribution of the minimal inhibitory concentrations of keigai-rengyo-to (krt) and of seijo-bofu-to (sbt) were almost the same as those of the kampo crude drugs, except cr and pc. ... | 1995 | 7897023 |
| [current status of the sapho syndrome]. | in 1987, our group proposed the acronym sapho (synovitis acne pustulosis hyperostosis osteitis) to identify a clinical entity with characteristic manifestations formerly described under a wide variety of names. since our first description, several new points have been recognized. for example it has been demonstrated that the skin lesions are not necessarily concomitant with osteoarticular manifestations sometimes separated by a long time interval. there are also several arguments suggesting a re ... | 1995 | 7899402 |
| effects of benzoyl peroxide and erythromycin alone and in combination against antibiotic-sensitive and -resistant skin bacteria from acne patients. | topical formulations of erythromycin and benzoyl peroxide are popular and effective treatments for mild to moderate acne vulgaris. use of the former is associated with resistance gain in both skin propionibacteria and coagulase-negative staphylococci, whereas use of the latter is not. we evaluated the efficacy of a combination of erythromycin and benzoyl peroxide against a total of 40 erythromycin-sensitive and -resistant strains of staphylococcus epidermidis and skin propionibacteria in vitro. ... | 1994 | 7918006 |
| growth curve for propionibacterium acnes. | we established growth curves for propionibacterium acnes isolates recovered from eyes with chronic postoperative endophthalmitis. the growth curve plotted the average of the duplicate bacterial concentration against time. the generation time for p. acnes calculated from the growth curves was approximately 5.1 hours. the growth of p. acnes is slower than other anaerobic bacteria. this may account for its delayed appearance in culture of ocular specimens. it may also explain treatment failure if t ... | 1994 | 7924410 |
| tumor necrosis factor-alpha regulates in vivo nitric oxide synthesis and induces liver injury during endotoxemia. | tumor necrosis factor-alpha is a principal mediator of the pathophysiological effects of endotoxemia and endotoxin shock. tumor necrosis factor-alpha also contributes to the stimulation of nitric oxide synthesis by the induction of the enzyme nitric oxide synthase in a variety of tissues. although the importance of tumor necrosis factor-alpha in the induction of nitric oxide synthase activity in vitro is well known, its role in in vivo nitric oxide synthesis has not been convincingly established ... | 1994 | 7927208 |
| evaluation of minocycline and cefuzonam for antimicrobial activity against clinical isolates. | the antibacterial activity of minocycline (mino) and that of cefuzonam (czon) were assessed with clinical isolates of 19 species, and compared with that of other antibiotics. mino was highly active against methicilli-sensitive staphylococcus aureus (mssa), neisseria gonorrhoeae, moraxella (branhamella) catarrhalis, haemophilus influenzae, helicobacter pylori, flavobacterium meningosepticum, acinetobacter calcoaceticus, peptostreptococcus spp. and propionibacterium acnes, but not as effective aga ... | 1994 | 7933531 |
| bacterial metabolism shown by magnetic resonance spectroscopy. | | 1994 | 7934568 |
| treatment of adolescent idiopathic scoliosis using texas scottish rite hospital instrumentation. | to determine the effectiveness of posterior tsrh instrumentation for the treatment of idiopathic scoliosis, 103 patients with a 2-year minimum followup were retrospectively studied. | 1994 | 7939996 |
| infectious arthritis due to propionibacterium acnes in a prosthetic joint. | | 1994 | 7948550 |
| infection caused by propionibacterium in children. | three hundred eighty-six isolates of propionibacterium sp. were recovered from 2,003 specimens studied for the identification of anaerobic bacteria in children during a 15-year period. three hundred forty-three (89%) of these were propionibacterium acnes. a total of 50 (13%) propionibacterium isolates identified from 45 patients were considered to cause infection. clinically significant infections caused by propionibacterium sp. were associated with bacteremia in 10 children; ear infection in ei ... | 1994 | 7955790 |
| [the protective effect of prostaglandin e1 in experimental model of massive live cell necrosis]. | the protective effect of pge1 in mice injected with propionibacterium acnes (p.acnes) and subsequently with a small dose of lipopoly-saccharide-endotoxin (lps) 7 days later was studied. the results of this study were as follows: (1) when pge1 was administered one hour before the injection of lps, the survival rate of mice was significantly higher (90%), than that of a control group (17%). no necrosis was found in the liver. (2) pge1 suppressed the release of tumor necrosis factor (tnf) and secre ... | 1994 | 7956562 |
| late-onset endophthalmitis after cataract surgery caused by propionibacterium acnes. | | 1994 | 7963475 |
| kupffer cell stimulation with corynebacterium parvum reduces some cytochrome p450-dependent activities and diminishes acetaminophen and carbon tetrachloride-induced liver injury in the rat. | chemical activation of kupffer cells in vivo by vitamin a or latex beads is associated with a worsening of hepatic injury induced by the p450-dependent hepatotoxins acetaminophen (acet) and carbon tetrachloride (ccl4) and by the p450-independent toxin galactosamine (gln). immunostimulants such as corynebacterium parvum (cp) also activate kupffer cells, but do so while prompting release of soluble mediators which depress microsomal oxidative activities in cultured hepatocytes. therefore, we sough ... | 1994 | 7974494 |
| a simple method for differentiation of propionibacterium acnes and propionibacterium propionicum. | tlc glycolipid profiles of several culture collection and clinical strains of propionibacterium acnes and propionibacterium propionicum were examined. the former were characterized by weak orcinol-positive minor glycolipids of type g, while the others had mainly strong orcinol-positive major glycolipids of type g. the simple and rapid small scale procedure seemed to be useful for differentiation of these phenotypically similar and genotypically closely related species irrespective of their serot ... | 1994 | 7988913 |
| the microaerophily and photosensitivity of propionibacterium acnes. | the effect of oxygen on the in vitro propagation of propionibacterium acnes was investigated under defined culture conditions. this micro-organism is the predominant bacterial resident within the pilosebaceous follicles of sebum-rich areas of human skin. the organism was grown in continuous culture in defined synthetic medium with glucose as the main carbon-energy source at various air saturation concentrations and in the presence and absence of light. steady state continuous cultures were achie ... | 1994 | 8002482 |
| the diagnosis of delayed post-operative endophthalmitis by polymerase chain reaction of bacterial dna in vitreous samples. | delayed post-operative endophthalmitis is a complication of modern cataract extraction and posterior chamber lens implantation. propionibacterium acnes has been isolated in a few such cases but the majority are culture-negative, compounding surgical and medical management decisions. a method of detecting bacterial, and specifically p. acnes, dna by the polymerase chain reaction (pcr) directed at 16s rdna is reported. nested pcr with universal eubacterial primers complimentary to regions of 16s r ... | 1994 | 8006933 |
| the antibiotic susceptibility of propionibacterium acnes and staphylococcus epidermidis isolated from acne. | we studied the susceptibility of antimicrobial agents to propionibacterium acnes (p. acnes) and staphylococcus epidermidis (s. epidermidis) isolated from acne patients. we measured the minimum inhibitory concentrations (mics) of the following five drugs: roxithromycin (rxm), erythromycin (em), clindamycin (cldm), minocycline (mino) and ofloxacin (oflx), which are frequently used to treat acne and skin infections. we found many resistant strains of s. epidermidis and some resistant strains of p. ... | 1994 | 8014270 |
| management of acne vulgaris. | acne vulgaris can affect both adolescents and adults. the pathogenesis of acne is multifactorial and involves overproduction of sebum, an abnormal follicular keratinization process, proliferation of propionibacterium acnes, and hormonal and immunologic factors. clinical manifestations of acne range from noninflammatory comedones to inflammatory papules, pustules and cysts. current therapy allows the physician to select a variety of topical and/or systemic antibiotics, retinoids, and hormone agen ... | 1994 | 8017261 |
| nitric oxide and prostaglandins interact to prevent hepatic damage during murine endotoxemia. | nitric oxide (no) and prostaglandins (pg) both possess the ability to induce vasodilatation and prevent the aggregation of platelets. the synthesis of these substances is increased following in vivo lipopolysaccharide (lps) infusion, but their function during sepsis is incompletely understood. we studied the role of no and pg in a murine model of chronic hepatic inflammation (corynebacterium parvum injection), which is known to progress to sudden hepatic necrosis after lps injection. no synthesi ... | 1994 | 8023933 |
| a quantitative comparison of selected bacteria in human carious dentine by microscopic counts. | the levels of selected cariogenic and obligately anaerobic bacteria have been compared in carious dentine taken from fissures, smooth surfaces, and root surfaces. the numbers of infected dentinal tubules were determined by immunohistological staining using species-specific antisera against selected bacteria. selective localization was observed; mutans streptococci were the predominant bacteria in dentine from fissures and smooth surface coronal caries, but not from root surface caries. the propo ... | 1994 | 8033185 |
| periprosthetic bacteria and the breast implant patient with systemic symptoms. | this report presents seven women with breast implants who experienced systemic symptoms which resolved rapidly after implant removal. a hypothesis is that these symptoms (which have been labeled "silicone poisoning" or "silicone adjuvant disease") may actually be caused by periprosthetic bacteria which have generally been considered innocuous, e.g., staphylococcus epidermidis. in these cases, systemic symptoms such as malaise, fatigue, diarrhea, muscle aches, and arthralgia rapidly resolved afte ... | 1994 | 8041821 |
| [the immunochemical therapy of warts and growths due to the papillomavirus]. | a complex immuno-chemical treatment (immuno-stimulation, blockage of virus replication, interferon induction) was applied to 23 patients with warts and vegetations with various localisations. results confirmed the treatment efficiency. | 1993 | 8043482 |
| [the beneficial effects of immunostimulating and antiviral therapy on ophthalmic zona]. | a group of 16 patients with ophthalmic zona zoster received antiviral and immunostimulating treatment with romanian specific products. results were spectacular. the problem of the identity of the varicella and zoster viruses is discussed. | 1993 | 8043484 |
| [seeking a causative agent of sarcoidosis]. | bacterial components (mdp and it27 antigen), demonstrated in sarcoid granulomas, strongly suggest the causative agent of sarcoidosis to be derived from some bacteria but many kinds of bacteria are known to have these bacterial components. our pcr detection of mycobacterial dna could not demonstrate a significant contribution of m. tuberculosis to the pathogenesis. we then developed a monoclonal antibody to the causative agent by immunizing mice with a crude homogenate of the affected lymph nodes ... | 1994 | 8046828 |
| [sarcoidosis and propionibacterium acnes]. | propionibacterium acnes (p. acnes) was isolated in high rates and in high concentrations from lymph nodes in patients with sarcoidosis. however, the precise mechanism of granuloma formation and immunomodulation by p. acnes has not been elucidated yet. in patients with sarcoidosis, it was found that the high levels of interleukin-2 released from alveolar lymphocytes as well as interleukin-1, tumor necrosis factor and interleukin-6 released from alveolar macrophages were stimulated by p. acnes. th ... | 1994 | 8046829 |
| using fura-2 to measure intracellular free calcium in propionibacterium acnes. | the fluorescent probe fura-2 was used to measure the intracellular free calcium concentration [ca2+]i in the gram-positive skin bacterium propionbacterium acnes. three methods for loading the probe into p. acnes were used. two consisted of using the membrane permeable acetoxymethyl ester of fura-2, fura-2/am, whereas in the third method, fura-2 was loaded directly into the bacteria by means of an acid shock procedure. one method using fura-2/am was found to be satisfactory. in this case, a stati ... | 1994 | 8050064 |
| effects of exercise on macrophage activation for antitumor cytotoxicity. | recent evidence suggests that exercise affects macrophage functions and that amount of exercise may be important. we determined effects of moderate (mod) and exhaustive treadmill running (exh) on 1) ability of macrophages to become activated for antitumor cytotoxicity after injection of heat-inactivated propionibacterium acnes in vivo, 2) macrophage responsiveness to activating agents lipopolysaccharide and interferon-gamma, and 3) role of glucocorticoids and various macrophage metabolic product ... | 1994 | 8063684 |
| shunt nephritis associated with propionibacterium acnes. | membranoproliferative glomerulonephritis was observed in a 22-year-old male patient in whom a ventriculoatrial shunt and a ventricular catheter were implanted after he was diagnosed in september 1989 with a cerebral cyst. propionibacterium acnes infection of a central nervous system shunt was diagnosed. the ventriculoatrial shunt was removed (the catheter had become embedded in tissue and was left in place) and the patient was treated with cefotaxime (3 x 2 g) for 14 days. renal function improve ... | 1994 | 8070938 |
| importance of early gamma interferon production in propionibacterium acnes-induced resistance to toxoplasma gondii infection in mice. | treatment of mice with heat-killed propionibacterium (p.) acnes conferred transient protection against toxoplasma infection. to investigate the mechanism of this nonspecific resistance, the production of gamma interferon (ifn-gamma) by p. acnes-injected mice was evaluated in comparison with that by noninjected controls upon infection with toxoplasma. mice pretreated with this bacterium produced significantly more ifn-gamma than that produced by control mice up to 24 hr of infection. a single inj ... | 1994 | 8075217 |
| two cases of soft-tissue infection caused by arcanobacterium haemolyticum. | | 1994 | 8075288 |
| itching in acne--an unusual complication of therapy. | pruritus at the site of active acne has not been described before as a complication of acne therapy. we report 8 cases seen over a 3-year period at our department with localized itching mainly at the active acne sites, within 2-6 weeks of starting effective acne therapy. seven had oral tetracyclines (oxytetracycline, vibramycin or minocin) with or without topical antibiotics or benzoyl peroxide. only 1 patient received oral isotretinoin. the severity of itch was mild to moderate in most cases wi ... | 1994 | 8075436 |
| anaerobic flora of the conjunctival sac in patients with aids and with anophthalmia compared with normal eyes. | relatively few investigations of anaerobic bacteria as ocular flora have been conducted, and their results have been contradictory. the conjunctival sacs of 22 normal subjects and of 14 patients with acquired immunodeficiency syndrome, and 22 anophthalmic sockets were cultured for anaerobic bacteria thirty-four (77.3%) of the 44 eyes of normal subjects harbored anaerobic bacteria; propionibacterium acnes was present in 28 eyes (63.6%), lactobacillus species in 6 eyes (13.6%), and veillonella spe ... | 1994 | 8079632 |
| failure of killed corynebacterium parvum in induction of protection in c57bl/6 mice against babesia rodhaini challenge infection. | we examined the survival rate of c57bl/6 mice challenged with babesia rodhaini 21 days post-killed corynebacterium parvum (kcp) inoculation in comparison with icr mice. all kcp-inoculated icr mice survived the challenge infection, while all kcp-inoculated c57bl/6 mice died. to account in part for the difference in protective effects of kcp, stimulatory effects of kcp on splenic phagocyte chemiluminescence (cl) response were investigated in c57bl/6 and icr mice. the kcp-inoculated icr mice exhibi ... | 1993 | 8117798 |
| antibacterial effects of various endodontic medicaments on selected anaerobic bacteria. | this study was undertaken to determine the antibacterial effects of various endodontic medicaments against six selected anaerobic bacteria. the experiment involved the testing of the vapors of six medicaments using agar plates streaked with the bacteria. a zone of inhibition was recorded for each plate and the results were analyzed statistically. formocresol produced significantly larger zones of inhibition than any of the other medicaments. | 1993 | 8120484 |
| an experimental model of acute liver injury using multicellular spheroids composed of rat parenchymal and non-parenchymal liver cells. | massive hepatic cell necrosis can be induced by corynebacterium parvum and lipopolysaccharide (lps) in rats. in this model, serum ldh, got and gpt activities are significantly increased in vivo within several hours after lps injection. an in vitro experimental acute liver injury animal model was produced by using multicellular spheroids composed of rat parenchymal and non-parenchymal liver cells. these multicellular spheroids were prepared by detaching the confluent monolayer on the collagen-con ... | 1993 | 8122032 |
| aggressive management of an epidemic of chronic pseudophakic endophthalmitis: results and literature survey. | six cases of chronic endophthalmitis following extracapsular cataract extraction and lens implantation are reviewed. all were referred for tertiary management by one surgeon over a period of just over 2 years. in two of the cases coagulase negative staphylococci were isolated and in three propionibacterium spp were retrieved. in the remaining case a mixed growth of coagulase negative staphylococci and propionibacterium acnes was cultured. the surgical management, microbiological results, and eve ... | 1994 | 8123618 |
| concurrent endophthalmitis and retinal detachment. | eyes with concurrent endophthalmitis and retinal detachment usually have a poor anatomic and visual outcome after treatment. the purpose of this study is to define the relation among the causative organism, the results of retinal detachment repair, and the final visual acuity. | 1994 | 8127569 |
| acne revisited. | | 1994 | 8129417 |
| contribution of complement-stimulated hepatic macrophages and neutrophils to endotoxin-induced liver injury in rats. | the role of complement as potential activator for tissue macrophages and neutrophils was investigated in an experimental model of endotoxin-induced liver injury in male fischer rats. injection of salmonella enteritidis endotoxin (1 mg/kg) into corynebacterium parvum-pretreated animals (7 mg/kg; single dose 6 days before endotoxin) resulted in severe oxidant stress, as indicated by a 37-fold increase of plasma levels of glutathione disulfide (basal concentration, 0.36 +/- 14 mumol/l), accumulatio ... | 1994 | 8138272 |
| platelet transfusion-related sepsis. | | 1993 | 8141706 |
| rapid identification using pyrolysis mass spectrometry and artificial neural networks of propionibacterium acnes isolated from dogs. | curie-point pyrolysis mass spectra were obtained from reference propionibacterium strains and canine isolates. artificial neural networks (anns) were trained by supervised learning (with the back-propagation algorithm) to recognize these strains from their pyrolysis mass spectra; all the strains isolated from dogs were identified as human wild type p. acnes. this is an important nosological discovery, and demonstrates that the combination of pyrolysis mass spectrometry and anns provides an objec ... | 1994 | 8144414 |
| endophthalmitis in auckland 1983-1991. | a review was made of 58 cases of suspected endophthalmitis presenting to auckland public hospital between january 1983 and july 1991 (103 months). thirty culture positive cases were found comprising 13 early onset postoperative, six delayed onset postoperative, five bleb-associated, four post-traumatic and two endogenous cases. the most frequent organism grown in postoperative endophthalmitis was staphylococcus epidermidis. no conclusion could be reached as to the effectiveness of early versus d ... | 1993 | 8148139 |
| detection of propionibacterium acnes polypeptides which have stimulated an immune response in acne patients but not in normal individuals. | patient and normal volunteer sera were used as probes in two-dimensional page of p. acnes culture supernatant fluid and cell extracts to determine whether specific p. acnes polypeptides were associated with the immune reaction in acne. eight polypeptides, m(r) 20 to 131 x 10(3), pi 4.7 to 6.5 in the cell extract, and 7 polypeptides m(r) 10 to 24 kd, pi 4.8 to 7.5 in the culture supernatant fluid were specifically highlighted by patient sera and not volunteer sera. these polypeptides were not rel ... | 1993 | 8156165 |
| naturally occurring antiacne agents. | antibacterial activity of various secondary metabolites from plants against propionibacterium acnes was tested. in addition, the study of combinations of compounds to enhance the total activity against this follicular bacterium was investigated. a series of long-chain alcohols was studied in great detail to gain new insights into the role of the hydrophobic alkyl groups in the activity. | 1994 | 8158169 |
| the modulation of tumour necrosis factor-alpha, interleukin-1 alpha and glucose levels with gmdp and other analogues of muramyl dipeptide. | immunomodulatory agent muramyl dipeptide (mdp) and seven of its analogues were tested for ability to counteract the toxic actions of lipopolysaccharide (lps) in experimental mouse models. female balb/c mice were presensitized with corynebacterium parvum (p. acnes) and given mdp or equimolar doses of one of its analogues after 2 weeks, followed by intravenous challenge with lps 18 h later. this treatment produced a sharp increase in blood cytokine (tnf-alpha, il-1 alpha) levels 4 h after lps admi ... | 1994 | 8167010 |
| therapy of experimentally induced coliform mastitis with a propionibacterium acnes product. | the efficacy of a propionibacterium acnes product for treatment of coliform mastitis was evaluated following intramammary infusion of escherichia coli. ten cows were injected intravenously with a product containing heat-killed p. acnes at 3 h, 3 d, and 7 d after bacterial challenge. five cows served as untreated negative controls. bacterial counts in milk, rectal temperatures, and milk scc did not differ between treated cows and control cows. intravenous infusion of p. acnes had no effect on mil ... | 1994 | 8182171 |
| bacterial contamination during extracapsular cataract extraction. prospective study on 200 consecutive patients. | postoperative endophthalmitis remains one of the most devastating complications of eye surgery. in recent years infections with so called 'nonpathogenic' organisms like propionibacterium acnes or coagulase-negative staphylococci have gained in importance. 200 patients were included in this study, from whom preoperative smears of the conjunctiva and intraoperative aspirates of the anterior chamber (at the start and at the end of the operation) had been taken. all samples were investigated for aer ... | 1994 | 8183529 |
| the cooperative effects of tnf-alpha and ifn-gamma are determining factors in the ability of il-10 to protect mice from lethal endotoxemia. | recent studies have demonstrated that interleukin-10 (il-10) has the capacity to protect mice from the lethal effects of endotoxin. in this investigation, we have examined the ability of il-10 to protect both normal mice and corynebacterium parvum-primed mice against endotoxin lethality. in the overwhelming majority of experiments, recombinant murine il-10 (rmuil-10) and recombinant human il-10 (rhuil-10) did not protect normal balb/cj mice from lipopolysaccharide (lps)-induced lethality at dose ... | 1994 | 8195696 |
| [antimicrobial activities of cefuroxime against recent clinical isolates]. | antimicrobial activity of cefuroxime axetil (cxm-ax) was compared with those of other cephem antibiotics against clinically isolated strains obtained mainly from outpatients of our center in a period from january to september of 1990 and 1993. minimum inhibitory concentrations were determined and the following results were obtained. 1. the results suggested that, compared with reports of studies conducted with clinical isolates in early 1980's, mic80 of cxm were equal to or lower against staphyl ... | 1994 | 8201767 |
| percutaneous discectomy for the treatment of bacterial discitis. | methods. percutaneous discectomy was successfully used to diagnose and treat bacterial discitis. conclusions. this technique was successful in obtaining a bacteriologic diagnosis, relieving the patient's symptoms and assisting in the eradication of the infection. with percutaneous discectomy, there is lower morbidity and cost than with open treatment. any comments on the overall effectiveness of this technique will need to be based on additional cases. | 1994 | 8202810 |
| induced hyporesponsiveness in rat kupffer cells is not specific for lipopolysaccharide. | the phenomenon of lipopolysaccharide (lps)-induced hyporesponsiveness has been reported to occur in macrophage cell lines and primary cells. hyporesponsiveness was evidenced by a diminution or lack of production of tumour necrosis factor-alpha (tnf-alpha) after sequential doses of lps. in order to characterize the hyporesponsive state in kupffer cells, the production of tnf-alpha was quantified after varying the concentration of a primary low dose of lps prior to a challenge with a high, normall ... | 1994 | 8206513 |