| species difference in the 5-hydroxytryptamine3 receptor associated with the von bezold-jarisch reflex. | species differences in the 5-hydroxytryptamine (5-ht)3 receptor among anesthetized rats, mice, rabbits, ferrets, dogs and guinea-pigs were examined in the transient bradycardia induced by i.v. injection of 5-ht (the von bezold-jarisch reflex). we also investigated the mechanism of the 5-ht-induced bradycardia in these species. 5-hydroxytryptamine and the selective 5-ht3 receptor agonists, 2-methyl-5-ht and m-chlorophenylbiguanide, dosedependently decreased heart rate in all species. in anestheti ... | 1995 | 8861711 |
| central connections of the motor and sensory vagal systems innervating the trachea. | cholera toxin beta-subunit was used as both a transganglionic and retrograde cell body tracer to determine respectively the central sensory and motor systems innervating the trachea in three mammalian species, dog, ferret and rat. a basic pattern was found in all three animals. sensory fibers terminated in three subnuclei of the nucleus tractus solitarius (nts) with the densest concentration localized in a restricted part of the medial part of the rostral nts. weaker projections were identified ... | 1996 | 8867085 |
| overrepresentation of the central visual field in the superior colliculus of the pigmented and albino ferret. | we have examined the retinotopy in the superior colliculus of pigmented and albino ferrets using both anatomical and electrophysiological methods. while the distribution of contralaterally projecting retinotectal ganglion cells is characterized by the presence of an area centralis superimposed on a visual streak in both strains, the ipsilateral projection from temporal hemiretina is strongly reduced in albinos. in spite of the significantly altered retinotectal projection pattern, the collicular ... | 1996 | 8870221 |
| soma and axon diameter distributions and central projections of ferret retinal ganglion cells. | using a combination of retrograde horseradish peroxidase (hrp) labelling, silver staining, and electron microscopy, we have assessed the relationship between retinal ganglion cell soma size and axon diameter in the adult ferret (mustela putorius furo). retinal ganglion cells were labelled following injections of hrp into the lateral geniculate nucleus (lgn), superior colliculus (sc), or lgn+sc. the soma size distributions following lgn, sc, or lgn+sc injections were all unimodal showing consider ... | 1996 | 8870232 |
| cutaneous epitheliotropic lymphoma in a ferret. | an 8-year-old spayed female ferret was examined for diffuse generalized alopecia, erythema, erosions, crusts, and ulcerated plaques that were nonresponsive to long-term administration of corticosteroids. cutaneous epitheliotropic lymphoma was diagnosed on the basis of histologic examination of skin biopsy specimens. neoplastic cells were determined to be of t-lymphocytic origin by results of immunohistochemical staining with a rabbit anti-cd3 monoclonal antibody. additional laboratory abnormalit ... | 1996 | 8870742 |
| isolation of differentially expressed cdnas during ferret tracheal development: application of differential display pcr. | the technique of differential display polymerase chain reaction (dd-pcr) was used to identify cdna sequences, which are temporally expressed during ferret tracheal airway development. such differentially expressed cdnas may ultimately prove to be useful markers in elucidating mechanisms of epithelial differentiation and submucosal gland development in the airway. using two sets of oligonucleotide primers 15 differentially amplified cdnas were isolated by comparative reverse transcriptase (rt) pc ... | 1996 | 8872086 |
| gr205171: a novel antagonist with high affinity for the tachykinin nk1 receptor, and potent broad-spectrum anti-emetic activity. | it has been demonstrated recently that antagonists of the tachykinin nk1 receptor, specifically cp-99,994 and gr203040, possess anti-emetic activity in a range of species. to optimise this activity, a series of analogues based around the structure of gr203040 have been synthesised and their affinity at the human tachykinin nk1 receptor determined. in addition, the potency of these analogues to inhibit emesis induced in the ferret by whole-body x-irradiation has been examined. a range of substitu ... | 1996 | 8876035 |
| the dorsal vagal complex of the ferret: anatomical and immunohistochemical studies. | to further the understanding of gastrointestinal function in this species, and in particular to advance our own work concerning central emetic pathways, the cytoarchitecture and the distribution of eight neurochemicals were studied in the ferret dorsal vagal complex (dvc; area postrema, nucleus of the solitary tract [nts] and dorsal motor nucleus of the vagus). the cytoarchitectural features of this region in the ferret were similar to those seen in other species; however, the ferret possesses a ... | 1996 | 8878086 |
| effects of bilateral auditory cortical lesions on gap-detection thresholds in the ferret (mustela putorius). | ferrets were tested for their ability to detect temporal gaps in noise before and after bilateral lesions of the primary auditory cortex. thresholds for gap detection were determined first for normal animals with band-pass noises at various center frequencies (0.5 to 32 khz) and at 8 khz with various sound pressure levels (-10-70 db). gap-detection ability improved steadily as sound pressure increased up to 70 db. no systematic relation was found between threshold and center frequency. to determ ... | 1996 | 8888999 |
| ionic mechanisms underlying synchronized oscillations and propagating waves in a model of ferret thalamic slices. | 1. a network model of thalamocortical (tc) and thalamic reticular (re) neurons was developed based on electrophysiological measurements in ferret thalamic slices. single-compartment tc and re cells included voltage- and calcium-sensitive currents described by hodgkin-huxley type of kinetics. synaptic currents were modeled by kinetic models of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa), gamma-aminobutyric acid-a (gabaa) and gabab receptors. 2. the model reproduced successfull ... | 1996 | 8890314 |
| the effect of cyclosporin-a on the oral microflora at gingival sulcus of the ferret. | the effect of cyclosporin-a (cya) on the dentogingival flora of ferrets with healthy and experimentally induced periodontal breakdown was studied. five animals were given 10 mg/kg/d cya. at the start of the experiments (day 0), ligatures were placed around 4 teeth in the right upper and lower jaws; corresponding contralateral teeth on the left side served as control. on days 0 and 28 (end of the experiment), microbiological samples were collected from the gingival sulcus of the experimental and ... | 1996 | 8891937 |
| redox modulation of l-type calcium channels in ferret ventricular myocytes. dual mechanism regulation by nitric oxide and s-nitrosothiols. | the effects of no-related activity and cellular thiol redox state on basal l-type calcium current, ica,l, in ferret right ventricular myocytes were studied using the patch clamp technique. sin-1, which generates both no. and o2-, either inhibited or stimulated ica,l. in the presence of superoxide dismutase only inhibition was seen. 8-br-cgmp also inhibited ica,l, suggesting that the no inhibition is cgmp-dependent. on the other hand, s-nitrosothiols (rsnos), which donate no+, stimulated ica,l. r ... | 1996 | 8894977 |
| electrophysiological and functional effects of adenosine on ventricular myocytes of various mammalian species. | the goal of this study was to determine the electrophysiological and functional effects of adenosine on ventricular myocytes of guinea pig, rabbit, rat, and ferret hearts. adenosine (100 microm) shortened the action potential durations of rat and ferret myocytes by 14 +/- 1 and 57 +/- 7%, reduced the amplitudes of cell twitch shortening by 13 +/- 1 and 54 +/- 5%, and increased outward currents by 15 +/- 4 and 55 +/- 5%, respectively, but had no effect on guinea pig and rabbit myocytes. the prope ... | 1996 | 8897829 |
| beta-oxidation in rabbit liver in vitro and in the perfused ferret liver contributes to retinoic acid biosynthesis from beta-apocarotenoic acids. | the biosynthesis of retinoic acid from beta-apocarotenoic acids was examined for a beta-oxidation-like process using both rabbit liver mitochondrial fractions with various beta-apocarotenoic acids (beta-apo-14'-, beta-apo-12'-, and beta-apo-8'-carotenoic acid) and perfusion in ferret liver through the portal vein with beta-apo-8'-carotenoic acid. the in vitro incubation of beta-apo-8', beta-apo-12'-, and beta-apo-14'-carotenoic acids gave rise to shorter chain beta-apocarotenoic acids as well as ... | 1996 | 8900117 |
| organization of retinal ganglion cell axons in the optic fiber layer and nerve of fetal ferrets. | previous authors have hypothesized that retinotopic projections may be influenced by 'preordering' of the axons as they grow towards their targets. in some nonmammalian species, axons are reorganized at or near the optic nerve head to establish a retinotopic order. data are ambiguous concerning the retinotopy of the mammalian retinal nerve fiber layer and whether fibers become reorganized at the optic nerve head. we have examined this question in fetal and newborn ferrets (mustela putorius furo) ... | 1996 | 8903028 |
| coinfection with intracellular desulfovibrio species and coccidia in ferrets with proliferative bowel disease. | | 1996 | 8905593 |
| development of local connections in ferret somatosensory cortex. | ferrets have become recognized as a useful and interesting model for study of neocortical development. because of their immaturity at birth, it is possible to study very early events in the ontogeny of the brain. we used living slices of ferret somatosensory cortex to study the formation and development of intrinsic elements within the neocortex. a small number of fixed, hemisected brains injected with 1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate (dii) were also used. the s ... | 1996 | 8906498 |
| alpha1-adrenergic stimulation induces early afterdepolarizations in ferret purkinje fibers. | the aim of this study was to evaluate whether alpha1-adrenergic stimulation, which prolongs repolarization, could induce early afterdepolarizations (eads) in ferret purkinje fibers. we used standard microelectrodes to study the effects of phenylephrine 10(-6)m in the presence of metoprolol 1.5 x 10(-6)m, on action potentials (ap) recorded from isolated ferret purkinje fibers superfused with normal tyrode's solution. phenylephrine induced a time-dependent prolongation of the ap duration at 60 and ... | 1996 | 8907792 |
| small intestine transplantation using a ferret model. | | 1996 | 8907931 |
| differential distribution of ampa receptors and glutamate during pre- and postnatal development in the visual cortex of ferrets. | immunohistochemical methods were used to study the distribution and time-course of appearance of cells expressing glutamate and alpha-amino-3-hydroxy-5-methyl-4-isoaxazole propionic acid (ampa)-type glutamate receptors (glur1 and glur2/3) during development of the ferret visual cortex. glutamate is present in many neurons in the ventricular zone, intermediate zone, developing cortical plate, and marginal zone as early as embryonic day (e) 34 (birth is at e41 in ferrets). glutamate attains its ad ... | 1996 | 8913890 |
| maturational gradients in the retina of the ferret. | in the present set of studies, we have examined the site for the initiation of retinal maturation in the ferret. a variety of maturational features across the developing inner and outer retina were examined by using standard immunohistochemical, carbocyanine dye labelling, and nissl-staining techniques, including 1) two indices of early differentiation of the first-born retinal ganglion cells, the presence of beta-tubulin and of neuron-specific enolase; 2) the receding distribution of chondroiti ... | 1996 | 8915829 |
| the action of the nk1 tachykinin receptor antagonist, cp 99,994, in antagonizing the acute and delayed emesis induced by cisplatin in the ferret. | 1. the anti-emetic effects of the nk1 tachykinin receptor antagonist, cp 99,994 (10 mg kg-1) were investigated in the ferret using a cisplatin-induced acute (day 1) and delayed (day 2 and 3) retching and vomiting model. 2. with a single cisplatin (10 mg kg-1) emetogenic challenge, the i.p. administration of cp 99,994 given as a single injection immediately following the first emetic episode, promptly abolished the retching and vomiting for a 4 h period. cp 99,994 was as efficacious as ondansetro ... | 1996 | 8922742 |
| infectious and parasitic diseases of captive carnivores, with special emphasis on the black-footed ferret (mustela nigripes). | captive carnivores are susceptible to a wide array of infectious and parasitic diseases, which reflects the diversity of the seven families of carnivora. unfortunately, relatively few in-depth studies have been conducted on diseases of non-domestic carnivores, and much remains to be learned, especially regarding diseases of small carnivores (e.g. mustelids, viverrids and procyonids). the more important infectious diseases of carnivores include rabies, canine distemper, and diseases caused by par ... | 1996 | 8924718 |
| stranguria in a castrated male ferret. | | 1996 | 8926212 |
| temperature and relative contributions of ca transport systems in cardiac myocyte relaxation. | the relative contributions of the different ca transport systems involved in cardiac relaxation were evaluated at 25 and 35 degrees c in isolated rabbit, ferret, and cat ventricular myocytes during twitches, caffeine-induced contractures in normal tyrode solution, and caffeine-induced contractures in na- and ca-free solution. the time course of intracellular [ca] decline these contractions in rabbit ventricular myocytes allowed estimates of the relative contributions of the sarcoplasmic reticulu ... | 1996 | 8928885 |
| effects of calponin on force generation by single smooth muscle cells. | although the actin-binding and actomyosin adenosinetriphosphatase (atpase) inhibitory properties of calponin are well documented in vitro, its function in the smooth muscle cell has not been elucidated. to address this question, we utilized the ferret aortic smooth muscle cell, which shows a protein kinase c-dependent contraction even at pca (-log [ca2+]) 9.0 in the absence of a change in myosin light chain phosphorylation. force was recorded from single, briefly permeabilized cells stimulated v ... | 1996 | 8928896 |
| the role of activity in the development of long-range horizontal connections in area 17 of the ferret. | horizontal connections in area 17 of adult cats and ferrets link cells with similar preferred orientations by a patchy network of projections extending several millimeters across the cortex. the maturation of orientation selectivity in ferret area 17 has been demonstrated previously by quantitative single-unit recording and optical imaging to begin at approximately postnatal days (p) 32-p36. we therefore made restricted injections of cholera toxin b-subunit (ctb) or ctb-gold into ferret area 17 ... | 1996 | 8929433 |
| effect of intracellular ph on ferret pulmonary arterial smooth muscle cell calcium homeostasis and pressure. | in this study, we investigated the role of na+/h+ antiport in regulating cytosolic (intracellular) ph (phi) in isolated and cultured ferret pulmonary arterial smooth muscle cells (psmc). we also studied the effects of modulating phi on the cytosolic (intracellular) calcium concentration ([ca2+]i) in the psmc and on the pulmonary arterial pressure (ppa) of isolated ferret lungs. phi was modulated by the nh4cl washout method. to eliminate the contribution of cl-/hco3- exchangers, the psmc and isol ... | 1996 | 8929590 |
| analysis of dynamic spectra in ferret primary auditory cortex. i. characteristics of single-unit responses to moving ripple spectra. | 1. auditory stimuli referred to as moving ripples are used to characterize the responses of both single and multiple units in the ferret primary auditory cortex. moving ripples are broadband complex sounds with a sinusoidal spectral profile that drift along the logarithmic frequency axis at a constant velocity. 2. neuronal responses to moving ripples are locked to the phase of the ripple, i.e., they exhibit the same periodicity as that of the moving ripple profile. neural responses are character ... | 1996 | 8930289 |
| analysis of dynamic spectra in ferret primary auditory cortex. ii. prediction of unit responses to arbitrary dynamic spectra. | 1. responses of single units and multiunit clusters were recorded in the ferret primary auditory cortex (ai) with the use of broadband complex dynamic spectra. previous work has demonstrated that simpler spectra consisting of single moving ripples (i.e., sinusoidally modulated spectral profiles that travel at a constant velocity along the logarithmic frequency axis) could be used effectively to characterize the response fields and transfer functions of ai cells. 2. a complex dynamic spectral pro ... | 1996 | 8930290 |
| relevance of the ferret model of helicobacter-induced gastritis to evaluation of antibacterial therapies. | the goals of the study were 1) to evaluate the efficacy of clinically relevant antibacterial therapies in the ferret model of helicobacter-induced gastritis and 2) to compare these results to the efficacy achieved clinically in humans. | 1996 | 8931416 |
| periapical changes after orthodontic movement of root-filled ferret canines. | the effectiveness of orthodontic forces in moving root-filled teeth and the degree of apical resorption it causes have been observed in an animal model. under general anesthesia, root canal therapy was performed on the mandibular canines on one side of 12 young male ferrets. bilateral movement of the canines was induced with an orthodontic spring (150 to 175 g). procion red dye was injected 1 wk presurgically to mark bone and cementum deposition. three months later, tooth movement was assessed f ... | 1996 | 8934989 |
| na(+)-k(+)-2cl- cotransport, na+/h+ exchange, and cell volume in ferret erythrocytes. | ferrets have high-na+ and low-k+ erythrocytes (113 and 5.4 mmol/l cell water) due to the lack of na(+)-k+ pumps. because ferret erythrocytes have a high capacity for na(+)-k(+)-2cl- cotransport, the present study was undertaken to evaluate cell volume-related changes in cotransport activity and its role in volume regulation. with cell shrinkage, na(+)-k(+)-2cl- cotransport is activated about twofold. a large bumetanide-insensitive na+ uptake component that has not yet been described is found in ... | 1996 | 8944644 |
| development of axonal arbors of layer 6 pyramidal neurons in ferret primary visual cortex. | we followed the development of axonal arbors of layer 6 pyramidal neurons in ferret striate cortex to determine whether early developing axon collaterals are formed specifically in the correct target layers from the outset or achieve their adult specificity by the elimination of initially exuberant projections. these neurons were chosen for study because they are amongst the first to be generated in the developing ferret's striate cortex, and, in mature animals, these cells have axonal arbors th ... | 1996 | 8951644 |
| spontaneous and mechanically evoked afferent activity originating from myelinated fibres in ferret inferior alveolar nerve neuromas. | the inferior alveolar nerve is a predominantly sensory branch of the trigeminal nerve which runs within a bony canal, and is frequently damaged in patients. a small proportion of these patients develop neuropathic pain, and this may result from neural activity generated at the injury site. to investigate this abnormality we have used electrophysiological techniques in an animal model to determine the level of spontaneous activity and mechanical sensitivity of myelinated fibres ending in a neurom ... | 1996 | 8951935 |
| protein kinase c mediation of ca(2+)-independent contractions of vascular smooth muscle. | tumour-promoting phorbol esters induce slow, sustained contractions of vascular smooth muscle, suggesting that protein kinase c (pkc) may play a role in the regulation of smooth muscle contractility. in some cases, e.g., ferret aortic smooth muscle, phorbol ester induced contractions occur without a change in [ca2+]i or myosin phosphorylation. direct evidence for the involvement of pkc came from the use of single saponin-permeabilized ferret aortic cells. a constitutively active catalytic fragme ... | 1996 | 8960355 |
| therapeutic immunization against helicobacter mustelae in naturally infected ferrets. | helicobacter infection of the gastric antrum is responsible for a number of gastric disorders. antibiotic therapy is lengthy and is not always effective. it has been shown previously that oral immunization against helicobacter felis in mice can prevent colonization after challenge. the aim of this study was to investigate the efficacy of therapeutic immunization in eradicating an established helicobacter infection and in reducing gastritis. | 1996 | 8964402 |
| distribution and hormonal regulation of androgen receptor immunoreactivity in the forebrain of the male european ferret. | the distribution and hormonal regulation of androgen-receptor-immunoreactive (ar-ir) cells in the male european ferret forebrain were examined. ar-ir cells were found in many limbic and hypothalamic structures, and their distribution was similar to that reported for cells that either bind androgen or contain ar protein or mrna in other species. regulation of brain ar immunoreactivity by gonadal steroids was brain-region dependent. in most regions examined, including the preoptic area, amygdala, ... | 1996 | 8978471 |
| axon decussation and midline glia in the developing ferret auditory hindbrain. | | 1996 | 8979801 |
| the development of topographically-aligned maps of visual and auditory space in the superior colliculus. | the role of the superior colliculus in attending and orienting to sensory stimuli is facilitated by the presence within this midbrain nucleus of superimposed maps of different sensory modalities. we have studied the steps involved in the development of topographically-aligned maps of visual and auditory space in the ferret superior colliculus. injections of fluorescent beads into the superficial layers showed that the projection from the contralateral retina displays topographic order on the day ... | 1996 | 8979840 |
| neurotrophin regulation of cortical dendritic growth requires activity. | neurotrophins have been proposed to mediate several forms of activity-dependent competition in the central nervous system. a key element of such hypotheses is that neurotrophins act preferentially on active neurons; however, little direct evidence supports this postulate. we therefore examined, in ferret cortical brain slices, the interactions between activity and neurotrophins in regulating dendritic growth of layer 4 pyramidal neurons. inhibition of spontaneous electrical activity, synaptic tr ... | 1996 | 8982155 |
| interaction of s 21007 with 5-ht3 receptors. in vitro and in vivo characterization. | the interaction of s 21007 [5-(4-benzyl piperazin-1-yl)4h pyrrolo [1,2-a]thieno[3,2-e]pyrazine] with serotonin 5-ht3 receptors was investigated using biochemical, electrophysiological and functional assays. binding studies using membranes from n1e-115 neuroblastoma cells showed that s 21007 is a selective high affinity (ic50 = 2.8 nm) 5-ht3 receptor ligand. as expected of an agonist, s 21007 stimulated the uptake of [14c]guanidinium (ec50 approximately 10 nm) in ng 108-15 cells exposed to substa ... | 1996 | 8982686 |
| changing patterns of expression and subcellular localization of trkb in the developing visual system. | neurotrophins play important roles in the survival, differentiation, and maintenance of cns neurons. to begin to investigate specific roles for these factors in the mammalian visual system, we have examined the cellular localization of the neurotrophin receptor trkb within the developing cerebral cortex and thalamus of the ferret using extracellular domain-specific antibodies. at prenatal ages (gestation is 41 d), trkb-immunostained fibers were observed in the internal capsule and as two distinc ... | 1996 | 8987824 |
| a role for nitric oxide in the development of the ferret retinogeniculate projection. | the ferret retinogeniculate projection segregates into eye-specific layers during the first postnatal week and into on/off sublaminae, which receive inputs from either on-center or off-center retinal ganglion cells, during the third and fourth postnatal weeks. the restriction of retinogeniculate axon arbors into eye-specific layers appears to depend on action potential activity () but does not require activation of nmda receptors (). the formation of on/off sublaminae is also activity-dependent ... | 1996 | 8987826 |
| canine distemper virus (cdv) infection of ferrets as a model for testing morbillivirus vaccine strategies: nyvac- and alvac-based cdv recombinants protect against symptomatic infection. | canine distemper virus (cdv) infection of ferrets causes an acute systemic disease involving multiple organ systems, including the respiratory tract, lymphoid system, and central nervous system (cns). we have tested candidate cdv vaccines incorporating the fusion (f) and hemagglutinin (ha) proteins in the highly attenuated nyvac strain of vaccinia virus and in the alvac strain of canarypox virus, which does not productively replicate in mammalian hosts. juvenile ferrets were vaccinated twice wit ... | 1997 | 8995676 |
| cardioprotection associated with preconditioning in the anesthetized ferret. | the cardioprotective effect of ischemic preconditioning (pc) was investigated in the anesthetized ferret model of myocardial ischemia followed by reperfusion. pc of 2, 5, or 10-min duration, followed by 10-min reflow, was studied in animals subjected to 60-min sustained lad coronary artery ischemia followed by 5-h reperfusion. infarct size was determined by tetrazolium staining. sham pc ferrets had a mean infarct of 72% of risk zone. a 2-min or 5-min cycle of pc significantly reduced tissue dama ... | 1996 | 8996628 |
| carbonic anhydrase and cardiac ph regulation. | membrane-bound carbonic anhydrase (ca) has recently been identified in mammalian cardiac tissue. in this study, we have investigated the histochemical location and functional role of ca in the ferret heart. heart sections stained by a modified hansson's technique showed ca to be located on capillary endothelial membranes as well as on sarcolemmal membranes. in the langendorff-perfused heart, washout of co2 brought about by switching perfusion between 25 mm hco3(-)-5% co2-buffered solution and no ... | 1996 | 8997183 |
| differentially regulated epithelial expression of an eph family tyrosine kinase (fhek2) during tracheal surface airway and submucosal gland development. | a ferret model was used to evaluate the potential role of an eph family tyrosine kinase (fhek2) in tracheal development of surface airway epithelium and submucosal glands. a partial 2.6-kb cdna fragment of fhek2 was isolated from a ferret tracheal/lung cdna library. sequence analysis demonstrated that this gene is the ortholog to the previously cloned human hek2 gene. in situ hybridization analysis of fhek2 mrna expression on ferret tracheal developmental time points revealed an expression patte ... | 1997 | 8998079 |
| an estimate of the participation of the sarcoplasmic reticulum in the intracellular ca2+ regulation in adult and newborn ferret hearts. | the aim of the present study was to estimate the participation of the sarcoplasmic reticulum in the ca2+ regulation of the contraction of newborn ferret heart. cyclopiazonic acid has been used to block the sarcoplasmic reticulum ca2+ pump in adult and newborn (1 month and 5-6 day old) ferret ventricles of intact and saponin-treated preparations. cyclopiazonic acid induced a decrease of the amplitude of the caffeine contractures generated in saponin skinned fibers. the sensitivity of the sarcopla ... | 1996 | 9008357 |
| safety study of the sag2 rabies virus mutant in several non-target species with a view to its future use for the immunization of foxes in europe. | the safety of the sag2 virus, a low virulence mutant of the sad strain, was investigated in ten species of mammals and seven species of birds liable to consume vaccine baits. these species are the western hedgehog (erinaceus europaeus), the meadow vole (microtus arvalis), the bank vole (clethrionomys glareolus), the water vole (arvicola terrestris), the field mouse (apodemus flavicollis or a. sylvaticus), the norway rat (rattus norvegicus), the european badger (meles meles), the domestic ferret ... | 1996 | 9014291 |
| topographic organization of projection from the parabigeminal nucleus to the superior colliculus in the ferret revealed with fluorescent latex microspheres. | unilateral, discrete injections of red and green fluorescent latex microspheres or injections of wheat germ agglutinin conjugated to horseradish peroxidase (wga-hrp) were made into the ferret's superior colliculus (sc) to characterize the topographic organization of the projection from the parabigeminal nucleus (pbn). retrograde labelling in the pbn revealed that this nucleus projects bilaterally to the sc, although the heaviest projection arises from the ipsilateral pbn. the pbn-sc projection d ... | 1996 | 9017249 |
| genetic diversity of the attachment (h) protein gene of current field isolates of canine distemper virus. | to characterize the variability of recent field isolates of canine distemper virus (cdv) from different hosts and geographical areas, we conducted nucleotide sequence analysis of the gene encoding the haemagglutinin (h), the attachment protein of this virus. pronounced differences between field isolates were revealed in comparison to the convac and onderstepoort vaccine strains. the diversity of cdv appeared to exceed that determined for measles virus. phylogenetic analysis also separated the fi ... | 1997 | 9018059 |
| molecular and phylogenetic analyses of the haemagglutinin (h) proteins of field isolates of canine distemper virus from naturally infected dogs. | we isolated three strains of canine distemper virus (cdv)--the ueno, hamamatsu, and yanaka strains--from dogs in japan and analysed the molecular properties of their haemagglutinin (h) proteins. immunoprecipitation of all three strains with a monoclonal antibody revealed h proteins with molecular masses of 84 kda, which differs from the molecular mass (78 kda) of the h protein of the onderstepoort vaccine strain. however, after tunicamycin treatment immunoprecipitation identified h proteins of i ... | 1997 | 9018060 |
| temperature sensitive mutants of influenza a virus generated by reverse genetics and clustered charged to alanine mutagenesis. | temperature sensitive (ts) mutants of influenza a virus have the potential to serve as live attenuated (att) virus vaccines. previously, ts mutants were isolated by chemical mutagenesis or arose spontaneously, and most likely contained point mutations in one or more genes. while sufficiently attenuated, even the most genetically stable of these viruses was found to revert to a more virulent form in a seronegative vaccinee. recently developed technology, however, allows the introduction of engine ... | 1996 | 9029775 |
| induction of deep layer cortical neurons in vitro. | transplantation studies suggest that the laminar fates of cerebral cortical neurons are determined by environmental signals encountered just before mitosis. in ferret, e29 progenitor cells normally produce neurons of layers 5 and 6. when transplanted during s-phase into an older ventricular zone, e29 progenitors produce neurons that change their fates and migrate to layer 2/3; however, cells transplanted later in the cell cycle migrate to their normal deep-layer positions even in an older enviro ... | 1997 | 9043072 |
| experimentally induced retinal projections to the ferret auditory thalamus: development of clustered eye-specific patterns in a novel target. | we have examined the relative role of afferents and targets in pattern formation using a novel preparation, in which retinal projections in ferrets are induced to innervate the medial geniculate nucleus (mgn). we find that retinal projections to the mgn are arranged in scattered clusters. clusters arising from the ipsilateral eye are frequently adjacent to, but spatially segregated from, clusters arising from the contralateral eye. both clustering and eye-specific segregation in the mgn arise as ... | 1997 | 9045732 |
| muscarinic analgesics with potent and selective effects on the gastrointestinal tract: potential application for the treatment of irritable bowel syndrome. | irritable bowel syndrome (ibs) is a pathopysiolocal condition characterized by abnormal bowel habits that are frequently accompanied by abdominal pain. current therapy based on reducing high-amplitude gi contractions with nonselective muscarinic antagonists is limited in efficacy due to typical muscarinic side effects and provides no pain relief. we have previously found potent antinociceptive agents acting through muscarinic receptors. in the present work, new 1,2,5-thiadiazole-based structures ... | 1997 | 9046345 |
| medial preoptic/anterior hypothalamic lesions induce a female-typical profile of sexual partner preference in male ferrets. | in t-maze tests given to gonadectomized ferrets treated daily with estradiol benzoate (eb), females consistently prefer to approach and interact sexually with a stud male whereas male subjects, on average, prefer an estrous female. in the present experiment this sexually allomorphic pattern of partner preference was changed in males given lesions of the medial preoptic area/anterior hypothalamus (mpoa/ah). electrolytic lesions, which caused extensive bilateral damage to the mpoa/ah, including th ... | 1996 | 9047276 |
| sexually dimorphic processing of somatosensory and chemosensory inputs to forebrain luteinizing hormone-releasing hormone neurons in mated ferrets. | the ferret is a reflexively ovulating species in which mating induces a preovulatory lh surge in the estrous female but significantly decreases lh secretion in the breeding male. this sexually dimorphic hormonal response is reflected in a sex difference in fos-like immunoreactivity (fos-ir) in forebrain lhrh and non-lhrh neurons after mating. we used dual immunocytochemistry for fos and lhrh to determine whether the sex dimorphism occurs in the initial detection and transmission or in the centra ... | 1997 | 9048618 |
| blockade of afferent impulse activity disrupts on/off sublamination in the ferret lateral geniculate nucleus. | the ferret retinogeniculate projection is organized into on/off sublaminae within each eye-specific layer. the role of afferent activity in the formation of these sublaminae was examined. we report that when the activity of retinal ganglion cells is blocked with tetrodotoxin during postnatal weeks three and four, on/off sublamination is disrupted, supporting a role for afferent activity in the formation of this pattern. | 1997 | 9051272 |
| the role of inward na(+)-ca2+ exchange current in the ferret ventricular action potential. | 1. inward na(+)-ca2+ exchange current (inaca) was either blocked in ferret ventricular cells by replacing extracellular na+ with li+ or substantially reduced by the almost complete elimination of the ca2+ transient by buffering intracellular ca2+ with the acetoxymethyl ester form of bapta (bapta am). 2. during square wave voltage clamp pulses to 0 mv, replacing extracellular na+ with li+ or buffering intracellular ca2+ with bapta am resulted in the loss of a transient inward current. this curren ... | 1997 | 9051574 |
| postmitotic neurons migrate tangentially in the cortical ventricular zone. | patterns of cell movement play a key role in the establishment of the brain's functional architecture during development. the migration of neuronal progenitor cells has been hypothesized to disperse clonally related cells among different areas of the developing cerebral cortex. to test this model, we explored the migratory patterns of cells in the proliferative zone of the intact cortex of the ferret. after focal injections of dii, labeled cells migrated in all directions and over long distances ... | 1997 | 9056775 |
| effect of nicotine on large bowel mucus thickness, eicosanoids and faecal proteinase in ferrets. | following observations on the effect of subcutaneous nicotine on rectal mucosal eicosanoids and mucus in the rabbit we have repeated the work in ferrets which may be a more suitable animal model. | 1997 | 9058630 |
| heterogeneity in k+ channel transcript expression detected in isolated ferret cardiac myocytes. | the molecular basis of the potassium ion (k+) channels that generate repolarization in heart tissue remains uncertain, in part because of the molecular diversity of the voltage-gated k+ channel family. in our investigation, we used fluorescent labeled oligonucleotide probes to perform in situ hybridization studies on enzymatically isolated myocytes to determine the identity, regional distribution, and cellular distribution of voltage-gated k+ channel, alpha-subunit mrna expressed in ferret heart ... | 1997 | 9058843 |
| genetically engineered live attenuated influenza a virus vaccine candidates. | we have generated new influenza a virus live attenuated vaccine candidates by site-directed mutagenesis and reverse genetics. by mutating specific amino acids in the pb2 polymerase subunit, two temperature-sensitive (ts) attenuated viruses were obtained. both candidates have 38 degrees c shutoff temperatures in mdck cells, are attenuated in the respiratory tracts of mice and ferrets, and have very low reactogenicity in ferrets. infection of mice or ferrets with either mutant conferred significan ... | 1997 | 9060631 |
| mechanisms of positive inotropic action of flosequinan, hydralazine, and milrinone on mammalian myocardium. | flosequinan is an arterial and venous dilator that also has a positive inotropic effect at relatively higher doses. the purpose of this study was to determine the mechanism of this positive inotropic effect in ferret papillary muscles loaded with the ca2+ indicator, aequorin. over the range of doses from 10(-6) to 10(-3) m, flosequinan produced a 61 +/- 9% increase in peak tension that was accompanied by a corresponding increase in [ca2+]i. this positive inotropic effect was not selectively bloc ... | 1997 | 9063689 |
| the tachykinin nk1 receptor antagonist pd 154075 blocks cisplatin-induced delayed emesis in the ferret. | the activity of a selective tachykinin nk1 receptor antagonist, pd 154075 ([(2-benzofuran)-ch2oco]-(r)-alpha-metrp-(s)-nhch(ch3) ph), was examined in radioligand binding studies, in a [sar9,met(o2)11]substance p-induced foot-tapping model in the gerbil, and in cisplatin-induced acute and delayed emesis in the ferret. in radioligand binding studies, pd 154075 showed nanomolar affinity for the human, guinea-pig, gerbil, dog and ferret nk1 receptors with an approximate 300 times lower affinity for ... | 1997 | 9063690 |
| an overview of randomised studies comparing 5-ht3 receptor antagonists to conventional anti-emetics in the prophylaxis of acute chemotherapy-induced vomiting. | ten years after it was demonstrated in the ferret that cisplatin-induced emesis could be blocked by the selective 5-ht3 receptor antagonist mdl 72222, 5-ht3 receptor antagonists have become routine anti-emetic agents for chemotherapy-induced emesis. however, although in association with highly emetogenic, mainly cisplatin-containing regimens, the use of these agents is well justified, the net benefit of 5-ht3 receptor antagonists in association with moderately emetogenic regimens has not been th ... | 1997 | 9071902 |
| chey-mediated modulation of campylobacter jejuni virulence. | four motile, non-adherent and non-invasive mutants of campylobacter jejuni 81-176 generated by a site-specific insertional mutagenesis scheme were characterized at the molecular level and all contained a duplication of the same region of the chromosome. when this region was cloned from wild-type 81-176 and transferred into 81-176 on a shuttle plasmid, the same non-invasive phenotype as the original mutants was observed, suggesting that the region contained a repressor of adherence and invasion. ... | 1997 | 9076738 |
| gastrointestinal motor activity in conscious ferrets. | gastrointestinal motility was measured with force transducers in conscious ferrets. the gastrointestinal motility pattern in both the interdigestive and digestive states was similar to that reported for humans. the activity front, phase iii contractions of the migrating motor complex, occurred cyclically in the antrum and migrated to the duodenum and ileum in the interdigestive state, and relatively low-amplitude contractions were sustained in the antrum, duodenum and ileum in the digestive stat ... | 1997 | 9083786 |
| the actions of ondansetron and dexamethasone to antagonise cisplatin-induced emesis in the ferret. | the ability of ondansetron and dexamethasone to antagonise cisplatin 10 mg/kg i.p. induced emesis was investigated in the ferret during a 24 h period. ondansetron 0.5-5 mg/kg, as a single injection, effectively antagonised the response for approximately 4 h and revealed a subsequent response that was sensitive to further ondansetron treatment. the three times per day administration of dexamethasone 1 mg/kg i.p. alone or combined with ondansetron 1 mg/kg i.p. significantly reduced the vomiting re ... | 1997 | 9088874 |
| centromeres, cenp-b and tigger too. | the highly conserved centromere-associated protein cenp-b is a common feature of mammalian centromeres. binding sites for cenp-b, so-called 'cenp-b boxes', are present in the otherwise unrelated centromeric satellite dnas of humans, mus musculus, mus caroli, ferrets, giant pandas, tree shrews and gerbils, suggesting a role for cenp-b in centromere function. however, cenp-b and its binding sites are not detected at the centromeres of mammalian y chromosomes and few, if any, binding sites seem pre ... | 1997 | 9097724 |
| effect of timing of treatment of the glyburide-reversible cardioprotective activity of bms-180448. | the effect of the timing of treatment with the atp-regulated potassium channel agonist bms-180448 was evaluated in isolated rat heart and ferret models of ischemia and reperfusion. in rat hearts, 10 microm bms-180448, given before and after global ischemia as well as only during reflow, improved reperfusion contractile function and attenuated lactic dehydrogenase release, although reperfusion-only treatment was less effective. cromakalim (10 microm) and bimakalim (10 microm) treatment before and ... | 1997 | 9103476 |
| biotransformation of chlorzoxazone by hepatic microsomes from humans and ten other mammalian species. | the 6-hydroxylation of chlorzoxazone (clz) is currently being used in both in vivo and in vitro studies to quantify cytochrome p450 2e1 (cyp2e1) activity in humans. comparatively little is known with regard to the biotransformation of this drug in other species. the nadph-dependent biotransformation of clz was therefore studied using hepatic microsomes derived from humans and ten other mammalian species. in all species, 6-hydroxychlorzoxazone (6oh-clz) was the only metabolic product that could b ... | 1997 | 9113344 |
| species-dependent differences in inotropic effects and phosphoinositide hydrolysis induced by endothelin-3 in mammalian ventricular myocardium. | 1. species-dependent variations in the positive inotropic effect (pie) of endothelin-3 (et-3), and the relationships between the pie and specific binding sites for [125i]-et-3 and the pie and the acceleration of phosphoinositide hydrolysis by et-3, were studied in ventricular muscles from the rat, guinea-pig, rabbit, ferret and dog. 2. et-3 in the presence of (+/-)-bupranolol (0.3 microm) and prazosin (0.3 microm) elicited a concentration-dependent pie in the ventricular muscle from the rat, gui ... | 1997 | 9113371 |
| [chemotherapy-induced nausea and vomiting: from experimentation to experience]. | chemotherapy-induced nausea and vomiting, two of the most distressing side-effects of cancer chemotherapy, have been the subject of a number of fundamental and clinical investigations. these have led to the development of a novel class of antiemetic agents, the 5-ht3 receptor antagonists. the pathophysiology of the emetic reflex and the clinical management of emesis are very complicated. two experimental preclinical animal models are available (ferret and dog) and are particularly used to assess ... | 1996 | 9116365 |
| dynamics of functional connectivity in visual cortical networks: an overview. | the aim of the royaumont symposium was to review various dynamic aspects of adaptive changes in functional connectivity, expressed in cortical networks during development, learning, and possibly during recognition and cognitive processing. the link between the various experimental and theoretical models was the comparison of cellular and molecular mechanisms that could be involved in the up- and down-regulation of functional connectivity, over different time scales. these processes have been inv ... | 1996 | 9116656 |
| the effect of cp-99994 on the responses to provocative motion in the cat. | 1. the nk1 receptor antagonist cp-99994 has been shown to prevent vomiting elicited by both peripherally and centrally acting emetogens in ferrets and dogs. these results have now been extended to another stimulus, provocative motion, and another species, the cat. 2. cp-99994 displaced [3h]-substance p from cat cortex with ic50 of 0.52 +/- 0.08 nm. following s.c. administration, peak plasma drug levels were achieved at 30 min. the plasma drug half life was 1.4 h. 3. subcutaneous administration o ... | 1997 | 9117085 |
| tachykinin nk1 receptor antagonists act centrally to inhibit emesis induced by the chemotherapeutic agent cisplatin in ferrets. | these studies have compared the pharmacological profile of two non-peptide human type neurokinin1 (hnk1) receptor selective antagonists, l-741,671 and a quaternised compound l-743,310. in radioligand binding studies l-741,671 and l-743,310 had high affinity for ferret and cloned hnk1 receptors [ki (nm) ferret 0.7 and 0.1; human 0.03 and 0.06, respectively] but low affinity for rodent nk1 receptors [ki (nm) 64 and 17, respectively] suggesting that ferret receptors have hnk1-like binding pharmacol ... | 1996 | 9121615 |
| synovial sarcoma in a ferret. | | 1996 | 9123789 |
| infection of the ferret stomach by isogenic flagellar mutant strains of helicobacter mustelae. | helicobacter mustelae, like helicobacter pylori, possesses two flagellin proteins, flaa and flab. isogenic mutant strains of h. mustelae have been constructed by disruption of the flaa or flab gene with a kanamycin resistance cassette or by introduction of both a kanamycin and a chloramphenicol resistance gene to produce a double mutant. to determine whether one or both flagellin proteins are necessary for colonization and persistence of infection with h. mustelae, 19 ferrets, specific pathogen ... | 1997 | 9125590 |
| immunoelectron microscopy of corticotropes and melanotropes in the pituitary gland of the european ferret, mustela putorius furo. | the superimposition technique and protein a-gold method of immunoelectron microscopy were employed to study the ultrastructure of corticotropes as well as melanotropes in the ferret pituitary gland. this is the first study ever elucidating the ultrastructural heterogeneity of melanotropes in mammalian pars intermedia on an immunocytochemical basis. morphological heterogeneity of pars distalis corticotropes has also been elucidated. it is suggested that the different subtypes may represent stages ... | 1996 | 9142335 |
| epidemiological analysis of malassezia pachydermatis isolates by partial sequencing of the large subunit ribosomal rna. | the opportunistic yeast malassezia pachydermatis is commonly recovered from both normal and diseased skin of warm-blooded animals. the diversity of m pachydermatis isolates obtained from a wide range of hosts was investigated by the partial sequencing of the large subunit (lsu) ribosomal rna. among 100 isolates examined, seven types (ia-ig) were discriminated on the basis of nucleotide sequence diversity. the seven types differed by one to five mutations, all of them corresponding to transitions ... | 1997 | 9160419 |
| a single-tube nested pcr for pneumocystis carinii f. sp. hominis. | a single-tube nested pcr which amplifies the internal transcribed spacer (its) regions of the rrna genes of human pneumocystis carinii was developed. the outer primers for the first pcr, which anneal to the 18s and the 26s rrna genes of p. carinii, were made to have a midpoint temperature (tm) of 74 degrees c. the inner primers for the second pcr have a tm of 56 to 58 degrees c and are specific for human p. carinii; they anneal to an area close to the beginning of its1 and the junction of its2 a ... | 1997 | 9163492 |
| helicobacter mustelae-associated gastric adenocarcinoma in ferrets (mustela putorius furo). | helicobacter pylori in humans is associated with active, chronic gastritis, peptic ulcer disease, and most recently has been linked epidemiologically to gastric adenocarcinoma. a related organism, helicobacter mustelae, naturally infects ferrets and also causes a persistent gastritis, a precancerous lesion, and focal glandular atrophy of the proximal antrum. in this report, we document the clinical presentation and histopathologic confirmation of h. mustelae-associated gastric adenocarcinoma in ... | 1997 | 9163879 |
| sexually dimorphic activation of midbrain tyrosine hydroxylase neurons after mating or exposure to chemosensory cues in the ferret. | mating with intromission induces a prolonged preovulatory lh surge in the estrous female ferret but inhibits lh secretion in the male. we used the dual immunocytochemical localization of fos (as a marker of neural activation) and tyrosine hydroxylase (th) to determine whether neurons containing norepinephrine or other catecholamines are activated after mating. breeding male ferrets were allowed to intromit with estrous females; both animals were perfused 90 min after the onset of intromission. o ... | 1997 | 9166692 |
| the effect of ca(2+)-calmodulin-dependent protein kinase ii on cardiac excitation-contraction coupling in ferret ventricular myocytes. | 1. the effect of ca(2+)-calmodulin-dependent protein kinase ii (camkii) on excitation-contraction coupling (e-c coupling) was studied in intact ferret cardiac myocytes using the selective inhibitor kn-93, kn-93 decreased steady-state (ss) twitch [ca2+]i (by 51%), resting ca2+ spark frequency (by 88%) and ss sarcoplasmic reticulum (sr) ca2+ content evaluated by eaffeine application (by 37.5%). 2. increasing extracellular ca2+ concentration ([ca2+]o) to 5 mm in kn-93 restored sr ca2+ load and ca2+ ... | 1997 | 9174990 |
| sources of subcortical projections to the superior colliculus in the ferret. | we have identified brainstem and other subcortical afferents to the superior colliculus (sc) in the ferret, by examining the pattern of retrograde labelling that resulted from unilateral injections of red and green fluorescent latex microspheres or of wheat germ agglutinin conjugated to horseradish peroxidase into different regions of this midbrain nucleus. labelled neurons were found in many structures, including somatosensory, visual and auditory nuclei. these subcortical inputs are almost all ... | 1997 | 9175895 |
| protective vaccination of ferrets against canine distemper with recombinant pox virus vaccines expressing the h or f genes of rinderpest virus. | to investigate the ability of rinderpest virus (rpv) antigens, expressed in pox virus vectors, to protect against canine distemper virus (cdv) infection in ferrets. | 1997 | 9185963 |
| influence of psychogenic and neurogenic stressors on endocrine and immune activity: differential effects in fast and slow seizing rat strains. | variations of plasma acth and corticosterone, as well as splenic macrophage activity and mitogen-induced cell proliferation, were determined in rats following 15 min of either the neurogenic stressor of restraint or by a purely psychogenic stressor consisting of exposure to a ferret. the effects of these stressors were assessed in two strains of rats that were selectively bred for either fast or slow kindling epileptogenesis triggered in response to amygdala stimulation. the stressors differenti ... | 1997 | 9193768 |
| in vitro and in vivo predictors of the anti-emetic activity of tachykinin nk1 receptor antagonists. | the ability of tachykinin nk1 receptor antagonists to inhibit gr73632 (d-ala-[l-pro9,me-leu8]substance p-(7-11))-induced foot tapping in gerbils was employed as an indirect measure of brain penetration and this was compared with their ability to prevent acute emesis induced by cisplatin in ferrets. (+)-gr203040 ((2s,3s and 2r,3r)-2-methoxy-5-tetrazol-1-yl-benzyl-(2-phenyl-piperidin- 3-yl)-amine), cp-99,994 ((2s,3s)-cis-3-(2-methoxybenzylamino)-2-phenyl piperidine) dihydrochloride), and l-742,694 ... | 1997 | 9196273 |
| clonal dispersion and evidence for asymmetric cell division in ferret cortex. | cell lineage analysis with retroviral libraries suggests that clonal progeny disperse widely in rodent cortex. to determine whether widespread dispersion is a general mammalian plan and to investigate phylogenetic differences in cortical development, we analyzed cell lineage in the ferret, a carnivore and near relative of the cat. the ferret possesses a highly developed, folded cerebral cortex, characteristic of higher mammalian species. progenitor cells of the ferret cerebral cortex were tagged ... | 1997 | 9199370 |
| regional localization of erg, the channel protein responsible for the rapid component of the delayed rectifier, k+ current in the ferret heart. | repolarization of the cardiac action potential varies widely throughout the heart. this could be due to the differential distribution of ion channels responsible for repolarization, especially the k+ channels. we have therefore studied the cardiac localization of erg, a channel protein known to play an important role in generation of the rapid component of the delayed rectifier k+ current (ikr), an important determinant of the repolarization waveform, cryosections of the ferret atrium and ventri ... | 1997 | 9201036 |
| are known pyrogenic cytokines responsible for fever in influenza? | the levels of interleukin (il)-1 beta, il-6, tumour necrosis factor (tnf)-alpha, and macrophage inflammatory protein (mip)-1 alpha released from human peripheral blood leucocytes (pbl) following interaction with influenza virus clone 7a (virulent, produces high fever in ferrets) and a/fiji (attenuated, produces relatively low fever in ferrets) were low and similar for the two viruses. neither strain induced interferon (ifn)-gamma and release of il-8 (which occurs on incubation of pbls alone) was ... | 1997 | 9210046 |
| synchronized oscillations in the inferior olive are controlled by the hyperpolarization-activated cation current i(h). | the participation of a hyperpolarization-activated cationic current in the generation of oscillations in single inferior olive neurons and in the generation of ensemble oscillations in the inferior olive nucleus (io) of the guinea pig and ferret was investigated in slices maintained in vitro. intracellular recordings in guinea pig or ferret 10 neurons revealed that these cells could generate sustained endogenous oscillations (4-10 hz) at hyperpolarized membrane potentials (-60 to -67 mv) after t ... | 1997 | 9212264 |
| helicobacter mustelae-associated gastric malt lymphoma in ferrets. | gastric lymphoma resembling gastric mucosa-associated lymphoid tissue (malt) lymphoma linked with helicobacter pylori infection in humans was observed in ferrets infected with h. mustelae. four ferrets with ante- or postmortem evidence of primary gastric lymphoma were described. lymphoma was diagnosed in the wall of the lesser curvature of the pyloric antrum, corresponding to the predominant focus of h. mustelae induced gastritis in ferrets. two ferrets had low-grade small-cell lymphoma and two ... | 1997 | 9212752 |
| development of primary visual projections occurs entirely postnatally in the fat-tailed dunnart, a marsupial mouse, sminthopsis crassicaudata. | we have examined the development of retinal projections in a diminutive polyprotodont marsupial, the fat-tailed dunnart, sminthopsis crassicaudata. here, we document the most immature mammalian visual system at birth described to date. at postnatal day (p) 0, the retinal ganglion cell layer has yet to form, and axons have not entered the optic stalk. by p4, the retinal ganglion cell layer could be distinguished at the posterior pole, and the front of growing axons extended one-third the length o ... | 1997 | 9214538 |
| distribution of technetium 99m-labeled red blood cells during isoflurane anesthesia in ferrets. | to address the physiologic mechanism of isoflurane-associated reduction in hematologic variables in ferrets. | 1997 | 9215458 |
| functional characterization of monoclonal antibody inhibitors of alpha 2-antiplasmin that accelerate fibrinolysis in different animal plasmas. | in humans with acute thrombotic disease, thrombi often appear to resist fibrinolysis induced by plasminogen activators. to examine the potential role of alpha 2-antiplasmin (alpha 2ap) in thrombus resistance in vivo, we generated monoclonal antibody inhibitors of alpha 2ap. in a somatic cell fusion, 99 hybridomas were obtained that produced mabs that bound to human 125i-alpha 2ap in a capture assay. screening assays showed that 3 of these mabs, 49, 70, and 77, neutralized the function of alpha 2 ... | 1997 | 9219039 |
| comparison of the 16s ribosomal dna sequences from the intracellular agents of proliferative enteritis in a hamster, deer, and ostrich with the sequence of a porcine isolate of lawsonia intracellularis. | proliferative enteritis is an enteric disease that affects a variety of animals. the causative agent in swine has been determined to be an obligate intracellular bacterium, lawsonia intracellularis, related to the sulfate-reducing bacterium desulfovibrio desulfuricans. the intracellular agents found in the lesions of different animal species are antigenically similar. in addition, strains from the pig, ferret, and hamster have been shown to be genetically similar. in this study we performed a pa ... | 1997 | 9226893 |