| role of interferon in prophylaxis of rabies after exposure. | rhesus monkeys were completely protected from rabies by a single dose of experimental, highly concentrated, rabies virus vaccine prepared from virus propagated in cultures of human diploid cells and administered several hours after infection with street rabies virus. protection seemed to be related to the high antigenicity of the vaccine and to its ability to induce interferon in vaccinated animals. only partial protection was afforded by one or three inoculations of less concentrated vaccines t ... | 1976 | 819599 |
| portal and peripheral vein insulin responses to intravenous glucose in the rhesus monkey. | catheterization of the portal vein and bilateral femoral veins were performed under general anesthesia in 6 healthy male rhesus monkeys. four days later, sequential, simultaneous peripheral and portal plasma samples were obtained for glucose and immunoreactive insulin determinations before and after administration of 0.5 gm. of glucose per kilogram (over a 1-minute period) via the opposite peripheral catheter. two phases of insulin secretion were noted in both portal and peripheral plasma sample ... | 1976 | 819601 |
| revitalization of pulpless open apex teeth in rhesus monkeys, using collagen-calcium phosphate gel. | | 1976 | 819611 |
| technique for placement of experimental indwelling carotid artery catheter. | a technique for placement of an indwelling carotid artery catheter in the rhesus monkey is presented. these indwelling catheters have proved useful in the investigation of regional cerebral blood flow using xenon-133, positive contrast angiography, and fluorescein angiography. although limited thus far to studies in experimental anemic stroke, this technique could be adapted to a variety of experimental situations in which serial evaluations of the cerebral vasculature are indicated. | 1976 | 819633 |
| a nonhuman primate vascular shunt model for thrombus generation. | a nonhuman primate model for thrombus generation was developed. three different types of test devices constructed of polystyrene or polyethylene-silastic were exposed to flowing blood in arterioarterial or arteriovenous vascular shunts in rhesus monkeys. the test device design included a simple tube, a vortical flow device, and a turbulent flow device. the amount of thrombus deposited within each individual test device after a 15-minute exposure to blood flowing through the shunt was determined ... | 1976 | 819713 |
| in vivo effect of dihydroxyacetone on oxygen-hemoglobin affinity in rhesus monkeys. | | 1976 | 819715 |
| evaluation and re-evaluation of genetic radiation hazards in man. ii. the arm number hypothesis and the induction of reciprocal translocations in man. | the arm number hypothesis proposed by brewen and collagues in 1973 has been examined in the light of information thus far available from mammalian studies. in experiments with peripheral blood lymphocytes (radiation in vitro), a linear relationship between dicentric yield and the effective chromosome arm number of the species was obtained in the mouse, chinese hamster, goat, sheep, pig, wallaby and man. however, the data are not consistent with such a relationship in several primate species (ma ... | 1976 | 819823 |
| prenatal genesis of connections subserving ocular dominance in the rhesus monkey. | in foetal monkey brain neuronal projections carrying input from the two eyes initially overlap; they segregate during the second half of gestation and become fully separated in subcortical visual centres and partially separated in the cortex three weeks before birth and thus before visual experience. | 1976 | 819835 |
| cryosurgical treatment of the nervus facialis in the rhesus monkey. | | 1975 | 819887 |
| methionine adenosyltransferase and transmethylation in fetal and neonatal lung of the human, monkey, and rabbit. | optimal conditions for the assay of methionine adenosyltransferase in crude extracts of human fetal lung were determined. maximal activity was obtained with 36 mm atp, 20 mm l-methionine, 240 mm mg++, and 160 mm k+. the ph optimum was 6.2--6.4, which is the same as that for adult human lung but lower than that for human liver. in human fetal lung, there was an increase in specific activity of methionine adenosyltransferase with increasing gestational age (r = 0.87; p less than 0.01) up to 25 wee ... | 1976 | 819897 |
| bile pigments in humans and in nonhuman primates during the perinatal period: composition of meconium and gallbladder bile of newborns and adults. | meconium of human infants and rhesus monkey infants (macaca mulatta) contained only about 0.10 of the amount of bilirubin in gallbladder bile of the same individuals. ninety-nine percent of the bilirubin in adult bile was conjugated. the proportion of conjugated bilirubin in infant bile and meconium was only slightly lower. adult bile contained more bilirubin disconjugates than monoconjugates, whereas only 20% of the bilirubin in infant bile and meconium was in the form if disconjugates. the pre ... | 1976 | 819898 |
| the effects of perphenazine on self-administration behavior. | in experiment 1.6 rhesus monkeys prepared with intravenous catheters responded on a fixed-ratio 10 schedule for either an injection of 0.2 mg/kg of cocaine or 0.5 mg/kg of pentobarbital during a daily 3 hr session. the substitution of saline or various doses of perphenazine resulted in very low rates of responding. these results indicate that perphenazine is not a positive reinforcer. pretreating animals maintained on 0.1 mg/kg or 0.2 mg/kg of cocaine with perphenazine resulted in increases in r ... | 1976 | 819940 |
| cocaine self-administration in monkeys by chewing and smoking. | two rhesus monkeys self-administered cocaine hydrochloride in a gum base vehicle on a fixed ratio 10 schedule with performance characterized by frequent pauses and increased intertrial interval responding. three other monkeys self-administered cocaine base in lettuce cigarette vehicles in smoking performance marked by shortened puff durations. urinary benzoyl ecgnoine levels correlated with amount of cocaine chewed or smoked. monkeys did not prefer cocaine gum in choice tests with plain or proca ... | 1976 | 819941 |
| ethanol as a positive reinforcer via the oral route for rhesus monkeys: maintenance of fixed-ratio responding. | two rhesus monkeys were required to emit 1 to 16 responses (fr 1, 2, 4, 8, and 16) per 0.5 ml delivery of either 8% (w/v( ethanol or water. ethanol had been established as an effective reinforcer via the oral route in an earlier experiment [4]. at fr 16, responding maintained by ethanol clearly exceeded responding maintained by water for both monkeys. the volume of ethanol intake per session remained nearly constant from fr 1 to fr 16, however, the volume of water consumed per session decreased ... | 1976 | 819942 |
| gastric antisecretory actions of (15s)-15-methyl prostaglandin e2 methyl ester and natural prostaglandin e2 in rhesus monkeys. | the gastric antisecretory actions of (15s)-15-methyl prostaglandin e2 methyl ester (me-pge2) and prostaglandin e2 (pge2) were evaluated in the unanesthetized gastric fistula rhesus monkey. secretion was submaximally stimulated by multiple subcutaneous injections of histamine acid phosphate given every hour for four consecutive hours. when a steady-state plateau of gastric secretion was reached, the pg's were administered as a single bolus dose either intravenously (i.v.) or intragastrically (i.g ... | 1976 | 819967 |
| physiopathologic responses of the rhesus monkey to live escherichia coli. | the present study was designed to develop an animal model applicable to the clinical patient in the investigation of the pathogenesis of septic shock. the model currently described is a lightly anesthetized, unrestrained monkey, carefully monitored during a 24 hour observation period. varying doses of live excherichia coli organisms were infused intravenously during a 30 minute period, and a variety of hemodynamic, respiratory and metabolic parameters were monitored. doses of organisms varied be ... | 1976 | 820005 |
| pathology of experimental rocky mountain spotted fever in rhesus monkeys. | rhesus monkeys were inoculated intravenously or intraperitoneally with various numbers of rickettsia rickettsii. monkeys that were given more than 10(4) organisms intravenously died on days 3-6 after inoculation, whereas those given less than 10(3) intravenously or more than 10(4) intraperitoneally died on day 7 or later. there was no significant difference in incidence of lesions between the early- and late-death groups. vasculitis and thrombosis occurred most frequently in the nares, pinna of ... | 1976 | 820052 |
| primate paneth cell degeneration following methylmercury hydroxide ingestion. | the effects of methylmercury on the intestinal epithelium were studied in 14 adolescent male macaca mulatta monkeys weighing 3 to 5 kg. they were divided into three groups: two controls received daily applesauce vehicle without methylmercury. nine chronic low-dose animals received 0.2 to 1.0 mg of methylmercury per day for 80 to 491 days. three acute high-dose animals received 2.0 mg methylmercury for 17 to 18 days, when they became terminally ill. light and electron microscopic observations wer ... | 1976 | 820204 |
| changes in blood serum constituents and hematologic values in macaca mulatta with rocky mountain spotted fever. | forty-seven male macaca mulatta, 3 to 4 kg weight, were inoculated intravenously or subcutaneously with various doses of yolk sac-grown rickettsia rickettsii. thirty-four macaques became febrile and exhibited signs of infection ranging from transient illness with a few days of fever to severe illness with subsequent death. the rash appeared more frequently in the macaques inoculated subcutaneously. febrile macaques that survived had leukocytosis, with concomitant neutrophilia. febrile macaques t ... | 1976 | 820224 |
| mother-infant separation in rhesus monkeys as a model of human depression. a reconsideration. | nineteen rhesus monkeys between the ages of 5.9 and 8.5 months were separated from their mothers in five different studies. while in two of the studies, data indicated behavioral responses roughly parallel to bowlby's protest-despair response to maternal separations, data across all five studies were sufficiently variable to bring this technique into serious question as a reliable and predictable animal model for neurobiologic and rehabilitative studies. | 1976 | 820307 |
| human and nonhuman operators in manual control systems. | the human operator in manual control systems is well known from a control theory point of view. the need for highly specialized data in an area which does not permit using human subjects resulted in the study of rhesus monkeys in manual control systems. the performances of monkey and human operators in a simple compensatory control system were similar. | 1976 | 820326 |
| effect of electromagnetic pulse on avoidance behavior and electroencephalogram of a rhesus monkey. | a 12-kg male rhesus monkey was exposed to electromagnetic pulse (emp) at 266 kv/m, 5 pulses/s, for 1 h (18,700 pulses). the effects of emp on sidman avoidance behavior and on post-exposure electroencephalogram were evaluated, and no significant changes were detected. an analysis of an emp showed that it contained various frequency components extending from 0 hz to 10(9) hz. however, the pulse configuration was such that its power was mainly confined to the longer wave-lengths (less than 30 mhz). ... | 1976 | 820328 |
| levels of ioglycamate (biligram) in the bile of the rhesus monkey following intravenous infusion at different dose-rates. | the maximun rate of excretion of ioglycamate in the bile of the rhesus monkey was achieved when the rate of adminstration was at least twice the rate of excretion. a maximum concentration of ioglycamate in the bile was also established, and this is more important to the visualization of the bileducts than the quanity of ioglycamate excreted. the maximum concentration was obtained at the same rate of infusion as that which produced the maximum rate of excretion. the peak concentration was sustai ... | 1976 | 820397 |
| roles of the facial, glossopharyngeal and vagus nerves in velopharyngeal movement. | the present study was designed to clarify the role of the motor nerves in velopharyngeal movements. experiments were carried out on 15 anesthetized rhesus monkeys on the assumption that their velopharyngeal structures are similar to those of human beings. the pattern and degree of velopharyngeal movements with stimulation to the facial, glossopharyngeal, and vagus nerves in the petrosal area were analyzed by means of fiberscopic observations. the results obtained were as follows: 1. velopharynge ... | 1976 | 820490 |
| studies on the biosynthesis of pulmonary surfactant. the role of the methylation pathway of phosphatidylcholine biosynthesis in primate and non-primate lung. | the relative importance of the choline incorporation and methylation pathways of phosphatidylcholine biosynthesis was studied in the rat, rabbit, rhesus monkey and human lung. in vitro studies showed that phosphatidylethanolamine methyltransferase activity in the lungs of all species was only a fraction of that in rat liver. in vivo experiments were carried out to study the incorporation of an intravenously administered equimolar mixture of l-[methyl-14c]-methionine and [methyl-3h] choline into ... | 1976 | 820492 |
| the functional organization of projections from striate to prestriate visual cortex in the rhesus monkey. | | 1976 | 820508 |
| carbonate dehydratase (carbonic anhydrase) and the fetal lung. | carbonic anhydrase activity (carbonic dehydratase, ec 4.2.1.1) has been detected in the fetal lungs of stillborn human infants and rhesus monkeys, but a role for this enzyme in the fetal lung has not been elucidated. in utero the mammalian lung develops as a liquid-filled structure, the liquid being secreted by the lung. in the fetal lamb this liquid, when compared with plasma, has a high chloride and a low bicarbonate concentration, suggesting a possible role for carbonate dehydratase. studies ... | 1976 | 820527 |
| a new radioimmunoassay for follicle-stimulating hormone in macaques: ovulatory menstrual cycles. | a sensitive and specific radioimmunoassay system for macaque follicle-stimulating hormone (mfsh) was developed utilizing an antiserum (h-31) prepared in a rabbit against purified ovine fsh as the immunogen. sera from castrated female, adult male, and juvenile rhesus monkeys, as well as urinary extracts from castrated rhesus and bonnet monkeys, were used to demonstrate parallelism with a standard of partially purified monkey pituitary gonadotropins (ler-m-907-d). an extract of baboon pituitary ti ... | 1976 | 820545 |
| pituitary stalk portal blood collection in rhesus monkeys: evidence for pulsatile release of gonadotropin-releasing hormone (gnrh). | hypothalamic-pituitary stalk portal blood was collected from 12 female rhesus monkeys. the pituitary stalk was approached transorbitally and cut at the level of the diaphragma sellae under direct visualization. after complete heparinization of the animal, stalk portal blood was obtained continuously, for periods of 30 minutes to 9 hours, using a constant exfusion pump at a rate of 30 to 40 mul/min. the mean gnrh in portal blood, as measured by radioimmunoassay, was 66 +/- 6.6 pg/ml (+/- se) in 7 ... | 1976 | 820547 |
| the anterior hypothalamus: how it affects gonadotropin secretion in the rhesus monkey. | the effects of hypothalamic lesions on spontaneous and estrogen-induced lh release were studied in 17 female rhesus monkeys with regular menstrual cycles. in the cycle before surgery, all of the animals experienced 3- to 10-fold increases in serum lh and elevated (above 3 ng/ml) serum concentrations of progesterone. three to 6 days after the onset of menstruation, lesions were made in the preoptic-anterior hypothalamic area (poa-aha) in 14 monkeys by radiofrequency thermocoagulation (rf) or by t ... | 1976 | 820548 |
| plasmodium knowlesi: morphology and course of infection in rhesus monkeys treated with clindamycin and its n-demethyl-4'-pentyl analog. | | 1976 | 820562 |
| effects of maternal mobility on the development of rocking and other behaviors in rhesus monkeys: a study with artificial mothers. | mechanically driven mobile artificial mothers effectively prevented the development of stereotyped body-rocking in rhesus monkeys. monkeys were maternally separated at birth and assigned to 2 groups. both groups were placed with surrogates, identical in construction except that for 1 group the surrogate was in motion 50% of the time from 0500 hours to 2400 hours each day, and for the other group the surrogate was stationary. all but 1 of the 10 monkeys raised with stationary artificial mothers d ... | 1975 | 820583 |
| looking behavior in monkeys raised with mobile and stationary artificial mothers. | rhesus monkeys raised with mechanically driven mobile artificial mothers for the first 10 months of life looked more at other animals and were more sensitive to stimulus differences than monkeys raised on stationary surrogates. both groups looked less and were not as discriminating as wild-born monkeys. the results are consistent with other evidence suggesting that one of the long-range consequences of maternal mobility is to reduce emotional responsiveness to novel situations. | 1975 | 820584 |
| responses of human-reared monkeys to strange simian calls. | the responses of 16 young (10-12 month and 19-20 month) hand-reared rhesus monkeys to rhesus vocalizations heard for the first time were recorded. the vocal stimuli were: (1) a "clear call" of a noncolony adult; (2) a "bark" of a noncolony adult; (3) a "bark" of a noncolony juvenile; and (4) a "bark" of a colony juvenile. behavior was video-tape recorded for 5-min periods preceding and following the calls and scored according to standard categories. the characteristic response to the stimuli was ... | 1975 | 820585 |
| the role of altered intestinal permeability in the pathogenesis of salmonella diarrhea in the rhesus monkey. | the pathogenesis of salmonella diarrhea is unclear. bacterial invasion of the ileal and colonic mucosa resulting in an intense ileocolitis regularly occurs in concert with secretion of water and sodium in jejunum, ileum, and colon. to examine the role of altered permeability in salmonella diarrhea we studied intestinal histology, water and electrolyte transport, clearance of intravenously injected [14c]erythritol and [3h]mannitol, and changes in transmural electrical potential difference in norm ... | 1976 | 820589 |
| modified polyriboinosinic-polyribocytidylic acid, an immunological adjuvant. | stabilization of polyriboinosinic-polyribocytidylic acid against enzymatic hydrolysis by addition of poly-1-lysine and carboxymethylcellulose (piclc) resulted in a compound with marked adjuvanticity. the primary antibody response of rhesus monkeys to formalin-inactivated venezuelan equine encephalomyelitis virus vaccine was significantly potentiated if the vaccine was combined with piclc prior to vaccination. the antibody response was maintained at a significantly higher level than controls for ... | 1976 | 820645 |
| observational determination of dose-response curves in hallucinogen-treated monkeys. | an objective behavioral profile that was previously shown to distinguish the effects of hallucinogens from those of other classes of drugs was used here to further study hallucinogenic behaviors. saline, d-amphetamine sulfate and five doses of dimethyltryptamine (dmt) were administered to solitary adolescent rhesus monkeys in a totally dark environment and their behavior was observed via infrared monitors, videotaped, and scored in a number of categories. scores in the following categories syste ... | 1976 | 820666 |
| experimental cerebral infarction in the monkey. radiographic evaluation of steroid therapy. | cerebral ischemia and infarction have been produced in the rhesus monkey using an autologous clot embolization technique. preliminary findings suggest that cerebral arteriography may be used to study experimental cerebral infarction and ischemia, and the resulting cerebral edema and also that cerebral arteriography may be used as a tool for the evaluation of various types of therapy now used clinically in the treatment of these entities. the present experimental study in the monkey suggests that ... | 1976 | 820668 |
| a neuroanatomical analysis of spinal cord injury in the rhesus monkey (macaca mulatta). | thirteen rhesus monkeys were subjected to impacts of either 200, 300, 400, oe 500 g-cm, on the dorsal surface of the spinal cord (allen 1911). six monkeys served as controls to determine the results of transection of the cord as well as the optimal survival time, and 2 additional subjects underwent the operative procedures only. most of the animals were sacrificed 1 week postoperatively and the brains and spinal cords were processed by the fink and heimer (1967) technique for degenerating axons. ... | 1976 | 820835 |
| serum lactate dehydrogenase of normal, stressed, and yellow fever virus-infected rhesus monkeys. | serum lactate dehydrogenase enzyme (sldh) was studied in both healthy and yellow fever virus (yfv)-infected young adult rhesus monkeys (macaca mulatta). in healthy monkeys, significant variation (p less than 0.001) was observed for both total activity and isoenzyme distribution among the following comparisons: individual monkeys, different days, different times of day, and caged versus chair-restrained monkeys (until 7 da after chair restraint). however, variability of baseline values was reduce ... | 1976 | 820921 |
| isoniazid: behavioral and biochemical effects in rhesus monkeys. | | 1976 | 820935 |
| a comparative study of the frequencies of radiation-induced chromosome aberrations in somatic and germ cells of the rhesus monkey (macaca mulatta). | frequencies of radiation-induced chromosome aberrations in spermatogonia, peripheral blood lymphocytes and bone-marrow cells of the rhesus monkey (macaca mulatta) and in human blood lymphocytes, were determined at different exposures of x-rays. the dose-response curve for the induction of reciprocal translocations in spermatogonia suggested a "hump" at about 200 rad. the absolute frequencies of chromosome aberrations in somatic and germ cells of the rhesus monkey were low in comparison with most ... | 1976 | 820989 |
| the glioarchitectonics of the rhesus monkey optic nerve. electron microscopic study. | | 1976 | 821027 |
| drinking device for rhesus monkeys. | a drinking device for rhesus monkeys is described which is simple, reliable, and permits intermittent scheduling of liquid availability. the device may be of particular use in oral drug self-administration experiments since the amount of fluid dispensed may be calibrated and spillage is minimals. the system has been successfully used for over 3 years with 9 unrestrained rhesus monkeys. | 1976 | 821063 |
| effect of fifty percent small bowel resection on gastric secretory function in rhesus monkeys. | basal acid output (bao) and histamine-stimulated acid output (mao) were studied in 11 fasting rhesus monkeys. serum gastrin and gastric inhibitory polypeptide (gip) were assayed in eight. fifty percent distal small bowel resection was performed and the studies were repeated at 6 weeks and 6 months. highly significant increases were seen in bao (0.37 "/- 0.05 to 1.73 +/- 0.37 meq. per hour; p less than 0.005) and mao (1.7 +/- 0.22 to 3.21 +/- 0.45 meq. per hour p less than 0.01) at 6 weeks. these ... | 1976 | 821162 |
| rhesus monkey platelet kinetics and storage. | rhesus monkey platelets that are separated, 51cr labeled, and transfused provide yields, 1/2 time and survivals similar to those obtained in man. rhesus platelets prepared and stored at room temperature for three days have 93 per cent of the yield of fresh platelets. when prepared and stored at 4c, the yield is only 54 per cent of fresh platelets. rhesus repeatedly transfused with platelets from random unmatched donors always have a significant decrease in the platelet 1/2 time and survival. thi ... | 1976 | 821183 |
| [the activity of rubrospinal neurons in macaca mulatta monkeys]. | action potentials of single cells in nucleus ruber have been recorded extracellularly inresponse to antidromic activation of the rubro-spinal tract and stimulation of contralateral interpositus nucleus of the cerebellum in the monkey m. mulatta. the analysis of the data obtained indicates that both large cells of the caudal portion and neurons of small-cell part of n. ruber send their axons to the spinal cord. conduction velocity along the axons of rubro-spinal neurons in monkeys veries within 1 ... | 1976 | 821269 |
| [experimental design: parenteral contraceptives in the rhesus monkey. introduction, method and results]. | | 1976 | 821286 |
| [fluhmann's theory in the female rhesus monkey]. | | 1976 | 821287 |
| fluorescence histochemistry of the surface epithelium and stroma in the rhesus monkey ovary. | the surface epithelium and stromal elements in the ovary of the rhesus monkey were studied with a variety of fluorescence-histochemical procedures to determine the relative distribution of specific chemical moieties. the surface (germinal) epithelium displayed high levels of cytoplasmic rna and specifically intense fluorescence with methods that demonstrate basic, sh and ss groups of protein. the underlying basement membrane demonstrated an intense reaction when fluorochromed with hydroxynaphtho ... | 1976 | 821301 |
| lack of antiscorbutic activity of ascorbate 2-sulfate in the rhesus monkey. | oral administration of 10 mg per kilogram of body weight of ascorbic acid (aa) completely prevented development of scurvy in juvenile rhesus monkey (mucaca mulata) fed an aa-free liquid diet. the same dose cured scurvy when injected intramuscularly. an equimolar dose of ascorbic acid 2-sulfate (aa-2-s) did not prevent or cure scurvy. neither aa nor aa-2-s altered serum cholesterol. aa but not aa-2-s reduced serum triglyceride. a case of scurvy in an aa-2-s treated monkey is described in detail. | 1976 | 821331 |
| malnutrition studies in macaca mulatta. v. effect on biochemical and cytochemical composition of major organs. | the effects of control, dilute, and low-protein duets on organ development were evaluated in infant rhesus monkeys. both experimental duets resulted in growth failure of the cerebral hemisphere, lung, liver, kidney, and muscle and, with few exceptions, in their total organ contents of water, protein, lipid, glycogen, dna, and rna. calculation of the various ratios for biochemical indices per mg of dna indicates that with the exception of increased glycogen:dna ratios in lung of animals fed the d ... | 1976 | 821333 |
| variability of neuropathologic lesions in experimental methylmercurial encephalopathy in primates. | acute and chronic intoxications of rhesus monkeys with methylmercury produced lesions in the central nervous system (cns) with different distributions. neuronal degeneration and astroglial proliferation predominated in the dentate nucleus, lateral geniculate nucleus, thalamus and pontine nuclei in 2 monkeys that received 2 mg/kg/day for 17 and 18 days, whereas pseudolaminar necrosis and astroglial proliferation were observed in the cerebral crotex, maximally in the calcarine and insular regions, ... | 1975 | 821350 |
| electroanesthesia (ea) studies: ea produced by stimulation of sensory nerves of the scalp in rhesus monkeys. | after it was learned that electroanesthesia (ea) could not be produced in a rhesus monkey which had undergone a circumferential scalp block with 0.25% lidocaine, it was postulated that ea could be produced by electrostimulation of the sensory nerves of the scalp in the rhesus. the work reported here verifies that ea can be produced by this method in this species; it is not necessary to pass current through the head. | 1976 | 821360 |
| [distribution, absorption and elimination of radioactivity following oral and intravenous application of 2'-14c-labelled cyproterone acetate to rhesus monkeys (author's transl)]. | 13 female rhesus monkeys were given 2'-14c-cyproterone acetate i.v. and p.o. the radioactivity of the blood plasma and the elimination in urine and faeces were then measured at suitable intervals for a period of 12 days. after i.v. administration the time for distribution in the body amounted to 8 h. the extrapolated initial concentrations in the equilibrium to distribution amounted to 0.68% of the administered dose in the plasma volume, and the theoretical volume of distribution was 5 times the ... | 1976 | 821492 |
| [pharmacokinetics of pramiverine in rats, dogs, and monkeys (author's transl)]. | the pharmacokinetic properties of 4,4-diphenyl-n-isopropyl-cyclohexylamine-hydrochloride (pramiverine, sistalgin) in wistar rats, beagles, and rhesus monkeys are described. after i.v. injection of 14c-labelled pramiverine incorporation of radioactivity from the blood into organs and tissues is rapid. the radioactivity is eliminated from the blood with a half-life of 4-7 h in rats, 17-32 in dogs, and 8-26 h in rhesus monkeys. unmetabolized pramiverine, in contrast, is eliminated much faster, the ... | 1976 | 821494 |
| [metabolism of pramiverine (author's transl)]. | the metabolite patterns of 4,4-diphenyl-n-isopropyl-cyclohexylamine-hydrochloride (pramiverine, sistalgin) in urine, feces, bile and serum of wistar rats, beagle dogs, rhesus monkey and man were analyzed with radio thin-layer chromatographic techniques. the structures of six pramiverine metabolites were elucidated. pramiverine is eliminated unchanged in only minute amounts via the renal, the biliary and the fecal route. consequently an almost quantitative absorption and metabolism takes place. m ... | 1976 | 821495 |
| neuropharmacological effects of methotrexate perfused through the cerebrospinal fluid system of the rhesus monkey. | thirteen adult rhesus monkeys were repeatedly perfused through the ventriculocisternal or ventriculolumbar spaces with elliott's b solution containing various concentrations of methotrexate (mtx) and trace amounts of [3h]mtx and [carboxy-14c]inulin. the concentrations of mtx ranged from 4.8 to 0.15 mg/ml representing perfusion dosages of 551 mg/sq m to 16 mg/sq m. the average steady-state concentration out-concentration in (co/ci) value for mtx was 0.78 +/- 0.04 for the ventriculocisternal and 0 ... | 1976 | 821606 |
| electrocardiographic effects of right atrial pacing and nitroglycerin in atherosclerotic rhesus monkeys. | right atrial pacing at rapid heart rates induced ischemic s-t segment changes in 19 atherosclerotic, male rhesus monkeys. prior administration of nitroglycerin (100 mug/kg, i.v.) prevented the s-t segment alteration at a given pacing rate in 5 animals, attenuated it in 12 others, and had no effect in the remaining 2. the results of these studies are similar to earlier ones in atherosclerotic rabbits. | 1976 | 821759 |
| primate social behavior as a method of analysis of drug action: studies with thc in monkeys. | the use of primate social behavior tests systems to characterize alteration of central nervous system (cns) function by lesioning, telestimulation, and psychoactive drugs is discussed. current observations of effects of acute and long-term chronic administration of delta9-tetrahydrocannabinol in group-caged rhesus monkeys are cited to demonstrate the sensitivity and specificity of primate social behavior test systems in characterization of cns drugs. the time course of drug action proceeds from ... | 1976 | 821783 |
| great apes and rhesus monkeys as subjects for psychopharmacological studies of stimulants and depressants. | a group of experiments is described in which chimpanzees and orangutans are utilized as subjects in research projects designed to evaluate the effects of stimulant and depressant drugs on learning and performance. efficiency of performance on a task which measures spaced responding was impaired when subjects smoked cigarettes containing delta9-tetrahydrocannabinol prior to testing. in a sequential learning task, these subjects also demonstrated reduced performance when stimulatn drugs were orall ... | 1976 | 821785 |
| assessment of cns drug activity in rhesus monkeys by analysis of the eeg. | the data generated from the application of spectral analytical techniques to the analysis of electroencephalograms (eeg) provide a reliable base for the quantification of such data. drugs with a wide range of central nervous system (cns) activities were characterized by their effects on neocortical eegs of macaca mulatta monkeys according to the specificity of autospectral changes at different anatomical sites. changes in total spectral power, in the shape of the spectral envelope, and in the re ... | 1976 | 821786 |
| seasonal rhythm in plasma testosterone levels in the rhesus monkey (macaca mulatta): a three year study. | | 1976 | 821844 |
| effect of hyperosmotic agents on the ciliary epithelium and trabecular meshwork. | hyperosmotic agents (2 m urea or 2 m dl-lactamide), perfused into the internal carotid artery of rhesus monkeys, produced a marked decrease in intraocular pressure and an increase in aqueous humor protein. fenestrae of the ciliary capillaries were broken immediately following the perfusion and the nonpigmented epithelium was separated from the pigmented epithelium. the pigmented epithelium especially of the pars plana then became degenerative. as intraocular pressure began to rise slowly, three ... | 1976 | 821895 |
| suppression of prolactin secretion by l-dopa in the stalk-sectioned rhesus monkey. | the effects of iv administration of l-dopa on serum prolactin were studied in both normal female rhesus monkeys and in monkeys in which the pituitary stalk had been previously sectioned. revascularization of the pituitary gland was prevented by the insertion of a silastic barrier over the diaphragma sellae. prolactin secretion was increased in all stalk-sectioned monkeys and, in contrast to intact animals, chlorpromazine administration was ineffective in further releasing prolactin. in both norm ... | 1976 | 821963 |
| retrosplenial cortex in the rhesus monkey: a cytoarchitectonic and golgi study. | the laminar and cellular structure of retrosplenial cortex in the rhesus monkey was studied with nissl stained and rapid golgi impregnated tissue and the results were used to evaluate morphological features of a cortical transition zone. the granular layer of retrosplenial granular cortex is composed primarily of small, density packed, star pyramidal cells. these cells branch within the granular layer itself, while the apical dendrite enters layer i where it branches infrequently or not at all. ... | 1976 | 821976 |
| organization of the hypothalamic-pituitary system: current concepts from immunohistochemical studies. | immunoperoxidase technique and light microscopy have been used to localize neurosecretory systems for vasopressin, oxytocin and related neurophysins (neurohypophysial peptides)) and gonadotropin-releasing hormone (gn-rh) in the rhesus monkey brain. all the neurohypophysial peptides were found in the magnocellular nuclei (suproptic and paraventricular) of the hypothalamus and in their projections to the posterior pituitary gland, the zona externa of the median eminence and the organum vasculosum ... | 1976 | 822099 |
| primate model of cerebral hematoma. | using specific anesthetic agents, permanent segmental occlusion of the proximal middle cerebral artery (mca) causes ischemic infarction limited to the putamen and other deep hemispheral structures in primates. using this model, 25 rhesus monkeys were subjected to acute arterial hypertension before, during and up to 5 days after onset of mca occlusion in order to reevaluate the possible role of the ischemic process in pathogenesis of cerebral hemorrhage. norepinephrine infusion induced prompt rap ... | 1976 | 822136 |
| proceedings: the effect of cooling parietal lobe areas 5 and 7 upon voluntary movement in awake rhesus monkeys. | | 1976 | 822153 |
| neuropathology of experimental vitamin b12 deficiency in monkeys. | we have produced severe vitamin b12 deficiency in rhesus monkeys by feeding them a defined experimental diet under controlled conditions. five years after institution of the deficient diet, the morphology and counts of peripheral blood and bone marrow are normal. gross visual impairment appeared in five of the monkeys between 33 and 45 months after the institution of the vitamin b12 deficient diet. subsequently, in three of the visually impaired animals, a gradually progressive spastic paralysis ... | 1976 | 822371 |
| [laser trabeculopuncture. iii experiments with rhesus monkeys]. | argon-laser trabeculopuncture was carried out on 7 rhesus monkeys. perforation of the trabecular meshwork was possible with laser impacts of 100 msec, 4,200 mw and a beam diameter of 50 mum. clinical and histological observations covered an interval of up to 15 weeks after coagulation. they revealed an obliteration of both the trabecular holes and the canal of schlemm after a few days. shorter pulse durations and higher energies might be helpful to improve the effectiveness, possibly assisted by ... | 1976 | 822382 |
| direct fascicular repair and interfascicular nerve grafting of median and ulnar nerves in the rhesus monkey. | the authors did direct fascicular suturing and interfasicular nerve graft repairs for gaps in the median and ulnar nerves in rhesus monkeys. they found that the fascicular type of repair, with or without the use of a graft, routinely produced good results in these animals. | 1976 | 822435 |
| behavioral effects of amphetamine in a group of rhesus monkeys with lesions of dorsolateral frontal cortex. | four macaques with lesions of dorsolateral frontal cortex and 4 normal monkeys were injected with 1 mg/kg d-amphetamine. observations of social behaviors and motor activity were conducted over a 1-month period. the results of this experiment show a partial dissociation of effects of amphetamines on behavior of normal and frontally lesioned animals. the frontal monkeys showed a dramatic increase in hyperactivity while normal monkeys showed a variable motor response to the drug. conspecific social ... | 1976 | 822440 |
| changes in cerebral blood volume and vascular mean transit time during induced cerebral seizures. | the relationship of the mean transit time of the vascular indicator c15o-labeled hemoglobin (tco) and the cerebral blood volume (cbv) as measured by stimulated x-ray fluorescence, to the mean arterial blood pressure (mabp) was examined in rhesus monkeys before and during experiment cerebral seizures. the results demonstrate a marked increase in cbv and a decrease in tco. a substantial portion of these changes is the passive accompaniment of the associated increase in mabp. | 1976 | 822474 |
| estrogen-induced luteolysis in the rhesus monkey: reversal with indomethacin. | normally cycling rhesus monkeys were treated with diethylstilbestrol (25 mg/day) alone or in combination with indomethacin (25 mg/day) for five consecutive days beginning in the early luteal and mid-luteal phase of the menstrual cycle. blood specimens were obtained daily to monitor corpus luteum function (progesterone), and the length of each menstrual cycle was recorded. diethylstilbestrol alone cause premature luteolysis as indicated by decreasing plasma progesterone and shortened menstrual cy ... | 1976 | 822478 |
| amine-responsive adenylate cyclase activity from brain: comparisons between rat and rhesus monkey and demonstration of dopamine-stimulated adenylate cyclase in monkey neocortex. | the effects of biogenic amines on adenylate cyclase from rhesus monkey brain have been surveyed. dopamine-responsive cyclase activity was found throughout the subcortical limbic area and limbic cortex, as well as in the sensorimotor cortex, where stimulation by dopamine was blocked by fluphenazine. cyclase activity from caudate nucleus in rat and rhesus monkey was very similar in relative responsiveness to stimulation by dopamine and norepinephrine. some response of the enzyme from cingulate and ... | 1976 | 822479 |
| changes in plasma could-insoluble globulin concentration during experimental rocky mountain spotted fever infection in rhesus monkeys. | | 1976 | 822532 |
| spatial summation, response pattern and conduction velocity of ganglion cells of the rhesus monkey retina. | | 1976 | 822584 |
| [formation and persistence of latexagglutination-inhibiting antibodies in rhesus monkeys infected with coxsackie virus type b4 (author's transl)]. | the formation and persistence of latexagglutination-inhibiting (lah), neutralizing (n), and complement-fixing (cf) antibodies were in rhesus monkeys afterr experimental infection with coxsackievirus type b4. in all 3 animals the lah antibodies showed a significant decrease between the 49th and 56th day after infection. in 2 cases the cf antibodies declined to 25% of their maximum titer on day 84 after infection, and in 2 animals the n antibodies declined between the 70th and 84th day afte infect ... | 1976 | 822619 |
| delayed dermal hypersensitivity in rhesus monkeys (macaca mulatta) immunized against plasmodium knowlesi. | eighteen rhesus monkeys were immunized with a fresh or lyophilized antigen preparation obtained from erythrocytes infected with plasmodium knowlesi. sixteen of these monkeys showed a positive delayed hypersensitivity response when subsequently skin tested with the immunizing antigen. ten of the 16 positive reactors survived a p, knowlesi challenge, the remaining 6 showed several indications of protection. none of the 18 control monkeys gave a positive skin reaction or survived the challenging in ... | 1976 | 822621 |
| vegetative innervation of the esophagus. iv. endings in the tela submucosa and tunica muscularis. | the osmium tetroxide-zinc iodide technique has been applied to the study of the tela submucosa and tunica muscularis in the esophagus of the cat and the rhesus monkey. other than the classical terminal vegetative formation, three types of endings were found, classified as perifascicular, free and intramuscular. the comparative results between cat and rhesus monkey show differences in the distribution and number of such endings. a sensory functional significance is proposed and discussed. | 1976 | 822680 |
| effects of trimethaphan and sodium nitroprusside on cerebral blood flow in rhesus monkeys. | in tranquilised spontaneously breathing rhesus monkeys we have found that trimethaphan can reduce systemic blood pressure by 20% with little or no change in cbf. this was in marked contrast to those given nitroprusside which showed signs of loss of autoregulation at a 5% mbp reduction. it is our opinion that the divergence of these results from other work might be explained in part by differing anaesthetic techniques and species variations. on this experience we would be hesitant to use sodium n ... | 1976 | 822698 |
| [effects of topical isoproterenol and propranolol on flow-rate of aqueous in rhesus monkey (author's transl)]. | | 1976 | 822701 |
| use of 14c-antipyrine for estimation of rhesus monkey eye blood flow. | the 14c-antipyrine content of rhesus monkey ocular and brain tissues are demonstrated to be stable between 10 and 60 seconds following infection of this diffusible compound, permitting the estimation of blood flow by the indicator-fractionation technique. blood flow values for central nervous system (cns) gray and white matter, optic nerve, and retina were similar to values previously obtained for primates by other blood flow techniques. | 1976 | 822711 |
| ocular damage induced by near-ultraviolet laser radiation. | a quantitative study was conducted of ocular damage thresholds in the rhesus monkey eye from krypton, argon, and nitrogen laser radiation. corneal and lenticular thresholds are reported for various laser beam parameters. corneal damage was found to occur following incident energy doses of approximately 60 to 70 joules per square centimeter (j./cm.2) for pulsewidths ranging from 250 musec to 120 sec. the results are consistent with a photochemical damage mechanism. with certain exposure parameter ... | 1976 | 822714 |
| umbilical vein occlusion and transient acceleration of the fetal heart rate. experimental observations in subhuman primates. | transient acceleration of the fetal heart rate is commonly seen in the cardiotachometer tracing of the human fetus during labor. a likely cause appeared to be partial occlusion of the umbilical cord. on the basis of this hypothesis, fetal cardiovascular responses to partial occlusion of the umbilical cord or isolated intra-abdominal portion of umbilical vein were studied in near-term pregnant baboons and rhesus monkeys prior to and following sympathetic blockade with dibenzyline and propranolol. ... | 1976 | 822718 |
| umbilical cord compression associated with amniotomy: laboratory observations. | impairment of umbilical cord blood flow has been associated with periodic fetal heart rate changes termed "variable decelerations." these patterns may be observed after amniotomy. a chronic fetal rhesus monkey preparation has been used to investigate this clinical observation. loss of amniotic fluid produced variable deceleration patterns, while restoration of amniotic fluid volume eliminated such changes. these experimental data demonstrate that amniotic fluid may be critical in protection of t ... | 1976 | 822720 |
| systemic and regional blood flow during epidural anesthesia without epinephrine in the rhesus monkey. | the radioactive-microsphere technique was used to determine distribution of cardiac output and regional blood flow in rhesus monkeys before and 10, 20, 40, and 80 minutes after induction of epidural anesthesia with lidocaine (1 per cent) without epinephrine. four monkeys were studied during low epidural anesthesia (sensory level t10) and five other monkeys were studied during high epidural anesthesia (sensory level t1). during t10 epidural anesthesia. during t1 epidural anesthesia, blood flow (p ... | 1976 | 822752 |
| use of the doubly tapered graft for the creation of a systemic-pulmonary arterial shunt. | it is now possible to construct vascular grafts of expanded polytetrafluoroethylene having complex configurations. in this series of experiments a double tapered graft was used to create a bypass shunt between the aorta and the pulmonary artery in rhesus monkeys and between the aorta and the iliac artery in dogs. when the synthetic material was placed under a slight degree of tension, a high degree of patency was achieved in animals killed three to six months following implantation. the use of t ... | 1976 | 822791 |
| ischemic carotid endothelium. transmission electron microscopic studies. | the endothelium of monkey and rabbit common carotid arteries subjected to ischemia was examined by transmission electron microscopy (tem). the right carotid artery of 24 rhesus monkeys was occluded by proximal and distal placement of removable surgical clips for periods ranging from five minutes to four hours. a single clip was used to occlude the right carotid artery of 15 rabbits for periods ranging from 5 to 30 minutes. with tem, numerous blebs, intracytoplasmic vacuoles, membranous whorls, a ... | 1976 | 822801 |
| avoidance behavior and ileum motility post-cingulumotomy in monkey. | two experiments were conducted utilizing rhesus monkeys to determine (i) the effects of cingulumotomy on conditioned-avoidance acquisition and extinction and (ii) the effects of avoidance learning on distal ileum motility in control- and cingulum-lesioned animals. active (aar) and passive (par) avoidance schedules singly or in combination were employed during short daily periods (less than 2 hr) of "shaping," training, acquisition, and extinction. the data indicated that the control-lesion and c ... | 1976 | 822886 |
| progressive effects of cocaine on behavior and central amine metabolism in rhesus monkeys: relationship to kindling and psychosis. | chronic administration of the same dose of cocaine to rhesus monkeys for up to 6 months was associated with progressive alterations in pathological behavior and increased susceptibility to seizures. monkeys initially displaying prominent hyperactive stereotypic responses for up to 2 months began to demonstrate increasing amounts of inhibitory behavior, consisting of catalepsy, motor inhibition, and abnormal visual tracking and staring. four of 13 animals developed increasing intensities of lingu ... | 1976 | 822887 |
| age, weight and weight gain in the individual pubertal female rhesus monkey (macaca mulatta). | | 1976 | 822891 |
| early changes in the electrocardiogram and vectorcardiogram and myocardial histology following coronary artery ligation in monkeys. | the ramus interventricularis anterior was ligated at different levels (upper, middle, low third) in 12 anesthetized monkeys (macaca mulatta). morphological changes and their localization were compared with the electrocardiogram (ecg) in 12 leads and vectorcardiogram (vcg) according to akulinichev's 5-plane system). the observations were performed for 6-7 hours after ligation. it has been established that upper third ligation of the ramnus interventricularis anterior caused ecg changes chiefly li ... | 1975 | 823041 |
| pre- and post-partum plasma amine oxidase differences in the rhesus monkey (macaca mulatta). | plasma amine oxidase activity increased from 23.4 nmol/ml/h during pregnancy to 49.5 nmol/ml/h during an extended post partum period in 10 rhesus monkeys. comparison with non-pregnant control monkeys sampled at similar times indicated that the significant differences were in the extended post partum period. | 1976 | 823045 |
| visual observing by rhesus monkeys: some relationships with social dominance rank. | | 1976 | 823059 |
| adjuvant effects of diethylaminoethyl-dextran. | diethylaminoethyl-dextran exhibited a significant effect on the primary immune response of rhesus monkeys to formalin-inactivated venezuelan equine encephalomyelitis virus vaccine (ivee). antibody formed to ivee and adjuvant followed a classic immunoglobulin m-immunoglobulin g pattern; however, as compared with vaccine alone, use of this adjuvant with ivee reduced the time required for onset of immunoglobulin g synthesis. | 1976 | 823105 |
| fluid and electrolyte transport in rhesus monkeys challenged intracecally with shigella flexneri 2a. | shigella flexneri 2a is an invasive enteric pathogen that may produce diarrhea when ingested by human beings and subhuman primates. we have previously shown that shigella diarrhea correlates with water and electrolyte transport abnormalities in the jejunum and colon. dysentery alone is associated only with colonic transport abnormalities. to define the relationship between invasion and inflammation of the colon and the occurrence of jejunal transport abnormalities, we studied water and electroly ... | 1976 | 823110 |
| effect on the reproductive functions of female rhesus monkeys of feeding irradiated wheat flour and potato diet. | we investigated the effects on reproductive functions of feeding adult rhesus monkeys on a diet of irradiated wheat flour and potato. wheat flour and potatoes were exposed to 75000 and 10000 rad, respectively, of gamma-irradiation and then fed to the animals. various parameters of reproductive function were compared with those of animals fed on unirradiated food. these were: external changes in the reproductive organs, menstrual cycle, vaginal cytology, assay of urinary hormones (oestrogens and ... | 1976 | 823122 |
| demonstration of rickettsia rickettsii in the rhesus monkey by immune fluorescence microscopy. | indirect immune fluorescence was used to detect rickettsiae in the tissues of a primate inoculated subcutaneously with rickettsia rickettsii. rickettsiae were identified by indirect immuno fluorescence predominantly in skin, skeletal muscle, scrotum, testicles, nares, heart, kidney, liver, brain, spleen, pancreas, and larynx. cell culture assay confirmed the presence of infectious organisms in those specimens. | 1976 | 823168 |