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reproduction, infant survival and productivity of a colony of common marmosets (callithrix jacchus jacchus).starting with 4 pairs of marmosets, 204 young were successfully reared during 6 years. they were kept in family groups of 2- 10. litter size varied from 1-4; singletons (2%), twins (35%), triplets (55%), and quadruplets (8%). the mean annual increase of weaned young was 3.24 per pair. the median interbirth interval was 154 days. of 46 pairs of marmosets, 8 failed to produce young. approximately 11% of young born were stillborn and a further 32% of all young born died within 3 weeks; perinatal mo ...19826801393
organ weight data in juvenile and adult marmosets (callithrix jacchus). 19816804710
plasma prolactin concentrations during the ovarian cycle and lactation and their relationship to return of fertility post partum in the common marmoset (callithrix jacchus).a heterologous double-antibody radioimmunoassay was used to measure plasma prolactin concentrations in 27 marmosets. the assay was valid for the marmoset because plasma levels of prolactin were increased in response to trh and metoclopramide and suppressed in response to bromocriptine treatment. during the cycle there were no consistent changes in plasma prolactin concentrations. during lactation mothers suckling single or twin infants had higher prolactin levels than did non-suckling females an ...19816788944
a new approach to the role of noradrenaline in learning: problem-solving in the marmoset after alpha-noradrenergic receptor blockade.nine marmosets (callithrix jacchus) were tested on a variety of visual discrimination learning tasks in a wisconsin general test apparatus with or without alpha-noradrenergic receptor blockade achieved by the administration of aceperone. after aceperone, animals were found to be severely and consistently impaired at learning the first task of each test session and to be impaired on new and repeated reversal learning. they were, however, unimpaired on learning another similar task in each test se ...19816114497
chronic tubulointerstitial nephritis and wasting disease in marmosets (callithrix jacchus).six marmosets (callithrix jacchus), 20 months to 16 years old, died from a disease characterized by weakness and paralysis of the hind legs, weight lose, anemia and transient diarrhea. the lesions most prominent at necropsy were subacute to chronic tubulointerstitial nephritis, subacute to chronic pancreatitis, and generalized hemosiderosis. chronic protein deficiency is believed to be the underlying pathogenic mechanism, since the diet contained no more than 15% animal protein during the last t ...19816806966
supplemental feeding of marmoset (callithrix jacchus) triplets.in a colony of marmosets (callithrix jacchus), all fifteen infants from five sets of triplet births were successfully reared with their parents. two supplemental feedings were given each infant daily. as an alternative to hand-rearing or foster rearing, the supplemental feeding method eliminated the time-consuming process of hand caring for an infant on a 24-hour per day basis.19816787328
demonstration of ocular dominance columns in a new world primate by means of monocular deprivation.we investigated the pattern transneuronally transported [3h]proline to the visual cortex of normal and deprived marmosets (callithrix jacchus). in the normal marmoset a continuous band of label was evident within layer iv of striate cortex. following injection of the closed eye of deprived marmosets, distinct fluctuations of label were apparent over the base of layer iv in both hemispheres. these results support the hypothesis that the presence of ocular separation of geniculo-striate afferents ...19816162527
competition for a desired food in family groups of the common marmoset (callithrix jacchus) and the cotton-top tamarin (saguinus oedipus).four captive groups of common marmosets (callithrix jacchus) and three groups of cotton-top tamarins (saguinus oedipus) were each presented with a desired food and their consumption was monitored. inequalities in consumption between individuals were found for each group of each species. generally, adult females consumed most of the desired food, followed by juveniles, and finally adult males. high consumption levels by all individuals during isolated feedings indicated that consumption inequalit ...19816789003
a micro-method for the evaluation of pha-responsive t cells in callithrix jacchus and macaca fascicularis. 19816802978
husbandry and breeding of a newly-established colony of cotton-topped tamarins (saguinus oedipus oedipus).from november 1976 to february 1979 a total of 8 litters were born to 6 females. of the 14 infants, 10 were successfully reared by their parents. housing, nutrition, a balance between environmental stability and stimulation, and female multiparity are seen as factors contributing to the breeding success of this colony. a controlled male and female pairing programme provided information on mating behavior and gestation length. one gestation of at least 166 days was observed, longer than that of t ...19816790834
pharmacologic manipulations of brain catecholamines and the behavior of callithrix jacchus (marmoset).in experiment 1, groups of marmosets were injected with 50 - 200 mg/kg l-dopa, 0.5 - 2.0 mg/kg apomorphine (ap), or 0.5 - 5.0 mg/kg methamphetamine. the number of head movements, number of body movements, number of times the tongue was extended, and the time the animal remained in an upright posture were scored during a 90-min period after the injections. l-dopa and ap induced large dose-dependent increases in body movements and time in upright posture. furthermore, the smallest dose of ap induc ...19816787644
the maturation and aging of the vertebrae of marmosets.this study deals with the growth, maturation, and age changes to the cartilaginous end-plates of vertebrae from marmosets (callithrix jacchus) varying in age from birth to 10 years. the cartilaginous end-plate is divided into an inner growth layer and an outer articular zone that abuts against the intervertebral disc. the growth cartilage gradually narrows and disappears by 1 year of age, when the animal reaches physical maturity. the articular cartilage undergoes changes in collagen and ground ...20096781074
a histological and histochemical study of normal and diseased skeletal muscle in marmosets callithrix jacchus. 19806793646
a case of placenta praevia in a common marmoset (callithrix jacchus). 20066776678
[histoenzymologic data on the epithelial cells of the gastric mucosa of marmosets (callithrix jacchus & callithrix penicillata)].the gastric mucosa of marmosets is devoid of udpg-gt; phosphorylases; g-6-pa; f-1,6-pa; alanyl aminopeptidase and leucine aminopeptidase. only the acid phosphatase was seen with a stronger reactivity in the chief cells. the other enzymes (ldh; g-6-pdh; 6-pgdh; nadph2-tr; cis-aconitase; icdh; sdh; mdh; cytochrome oxidase; nadh2-tr; a-gpdh; b-ohbdh and nonspecific esterase) showed a stronger reactivity in the parietal cells.19806774386
cemented annulation as an age criterion in the common marmoset (callithrix jacchus).teeth from 18 marmosets, seven months to 5.8 years of age, were studied histologically. a minimum of one dark and one light band comprised one cemental annulation. age was estimated by counting the number of annulations and adding four months to premolar and eight months to canine teeth for tooth development. cemental annulations were most consistent near the gingival border on the labial aspect of the tooth. the method will be valuable in estimating the ages of marmosets and other nonhuman prim ...19806777495
indoor-outdoor housing systems for a self-sustaining marmoset breeding colony.indoor-outdoor housing of three types was designed, constructed, used and evaluated for housing a breeding colony of common (callithrix jacchus) and cottontop (saguinus oedipus) marmosets. all types were relatively inexpensive to construct, required minimal care, simulated a natural environment and allowed for some isolation between units and between individual runs within units.1979119116
'collaborative' rearing of marmoset triplets.a system of management is described in which all 3 offspring from triplet births to callithrix jacchus can be successfully reared to weaning. hand-rearing techniques are applied to the offspring in turn without depriving them of the maternal and family influences necessary for normal behavioural development.1979113619
anomalous origin of the right subclavian artery in a marmoset (callithrix jacchus).anomalous right subclavian artery in a one-day-old marmoset (callithrix jacchus) is reported. the anomalous vessel originated with the left subclavian artery from a short trunk off the arch of the aorta, then passed posterior to the esophagus, indenting it.1979119861
[callithrix jacchus, marmoset: a new experimental model; a review of the literature]. 1979117651
sex determination in the common marmoset (callithrix jacchus).the general morphology of the external genitalia was examined in 43 common marmosets (callithrix jacchus) ranging in age from newborn to adult. at birth, the scrotum was a small irregular fold of skin on either side of the caudal aspect of the penis. the testes were not present in the scrotum until 8--11 months of age. the scrotum covered the penis in the adult male, was devoid of fur, was covered by pearly while nodules, and presented a median raphe. in the young female, the pudendal pad closel ...1978416296
[transferrin findings in callithrix jacchus linné, 1758 (primates, platyrrhina)].this paper deals with the transferrin (tf) polymorphism in the south american marmoset callithrix jacchus. the transferrin bands of this species are positioned in the electropherogramme cathodal to the beta1c-globulin (c 3), s. fig. 1. by means of the combined agarose gel immuno-electrophoresis 7 distinguishable phenotypes have been detected in 166 animals (s. fig. 2). the formal genetic analysis of 28 matings with 48 youngs (cf. table 1) leads to the assumption that at least 4 codominant allele ...1978414654
observations on a colony of cotton eared marmosets callithrix jacchus with some plans for future expansion.the current and proposed colony design and management are described. in an effort to increase the neonatal survival of marmosets, an outdoor-indoor housing arrangement is planned.1978417333
callithrix jacchus jacchus as a subject for behavioural projects in biomedical research. 1978417326
the use of marmosets (callithrix jacchus) in teratological and toxicological research. 1978417324
lymphocyte populations of callithrix jacchus marmosets. 1978413631
histochemical observations on the taste buds of the marmosets (callithrix jacchus and callithrix penicillata).the epithelial cells in the taste buds of c. jacchus and c. penicillata show a moderate amount of ribonucleic acid an a concentration of a pas-positive diastase-resistant material at their apical part. these cells are devoid of udpg-gt, phosphorylases, g-6-pa, alanyl aminopeptidase, leucine aminopeptidase, cholinesterase and mao; they present a weak reaction of f-1, 6-p ald, ldh, sdh, mdh, cytochrome oxidase, beta-ohbdh, nonspecific esterase and acid phosphatase and a stronger reaction to adh, n ...1978155939
the common marmoset (callithrix jacchus jacchus) as a model for ethological research.the uses and advantages of the common marmoset (callithrix jacchus jacchus) as an animal model for ethological research were examined. it was found that this species had advantages over old world primates for work on social behavior as a nearer approximation to the group structure occurring in natural conditions could be obtained in the laboratory. the small size of the common marmoset also made it easier to handle and cheaper to maintain. the adult female gave birth at five-month intervals and ...1977413004
testicular steroidogenesis in the common marmoset, callithrix jacchus. 1977407949
topographically organized reciprocal connections between areas 17 and mt (visual area of superior temporal sulcus) in the marmoset callithrix jacchus.with the aid of the techniques of tracing axonal pathways by anterograde fiber degeneration, and by anterograde (autoradiography) and retrograde (hrp-histochemistry) axoplasmic transport, it could be shown that area 17 projects in a topographically and visuotopically organized manner onto the temporal visual area mt. the fibers of this association system originate from pyramidal cells in layer iiic, and from the solitary cells of meynert; they terminate in layers iv and iii of area mt. a corresp ...1977404175
histochemical studies on the submandibular ganglia of marmosets (callithrix jacchus and callithrix penecillata).the histochemistry of the neural cells was studied in the submandibular ganglia of 5 callithrix jacchus (3 males and 2 females) and 4 callithrix penicillata (2 males and 2 females). these cells contain neutral mucopolysaccharides, nucleoproteins and lipidic materia, but are apparently devoid of glycogen. it is impossible to demonstrate in them any reactivity for udpg-gt, phosphorylases, atpase at ph 6.3, leucine aminopeptidase and alanyl aminopeptidas. the reaction for the other searched enzymes ...1977142413
skeletal development in the foetal and neonatal marmoset (callithrix jacchus).qualitative and quantitative measurements of skeletal development were performed on foetal marmosets in utero and on fixed specimens of both foetuses and neonates. the sequence of skeletal changes may be used to assess developmental status and the prenatal growth of the marmoset is compared with that of other primate species.1976823366
comparative autoradiographic and metabolic study of delta8- and delta9-tetrahydrocannabinol in the brain of the marmoset callithrix jacchus.the label distribution in the brain of the marmoset callithrix jacchus following intravenous application of radioactively labeled delta8-tetrahydrocannabinol (delta8-thc) and delta9-thc is investigated by autoradiographic technique. accumulations of label are observed in nuclei concerned with motor function, in the optic and acoustic pathways, and a few other structures. of the two hydroxylated isomeres which were shown to be equally psychoactive the brain concentration of 11-oh-delta9-thc was f ...1976822439
an ethogram of the common marmoset (calithrix jacchus jacchus): general behavioural repertoire.the behavioural repertoire of four captive breeding pairs of callithrix jacchus jacchus is described. social communication took the form of postures, facial expressions, vocalizations and piloerection displays. detailed analyses were made of piloerection displays, adult play, copulatory, aggressive, and prey-catching behaviour. aggressive behaviour was uncommon in adult mated pairs. play between adults showed a degree of temporal of temporal organization. vocalizations were the main methods of i ...1976820223
the effect of dexamethasone in traumatic changes of the periodontium of marmosets (callithrix jacchus).the systemic administration of steroid hormone (0.400 mg of dexamethasone every 2 days), during a 28-day period in marmosets (callithrix jacchus) produced modifications in the evolution of the experimental periodontal traumatism. the observed changes were osteoporosis and reduction of the periodontal fibers in quantity as well as a reduction of repair process, when compared to the control group that only received the action of the trauma from occlusion.1976815537
histochemical differences between the major salivary glands of the marmosets (callithrix jacchus and callithrix penicillata).histoenzymologic differences between the parotid, paramandibular and submandibular glands were studied in six callithrix jacchus (four males and two females) and four callithrix penicillata (three males and one female). the acinous cells of the paramandibular glands showed a stronger reactivity for the diaphorases (nadh2-tr and nadph2-tr) and for a certain group of enzymes of the carbohydrate metabolism (f-1-6p ald, ldh, adh, g-6-pdh and 6-pgdh), lipid metabolism (alpha-gpdh, beta-ohbdh, alkalin ...1976827738
the skin of the palms and soles of the marmosets (callithrix jacchus and callithrix penicillata).the structure and histochemistry of the palmar and plantar skin were studied in four adult male marmosets (two callithrix jacchus and two callithrix penicillata). in this skin there exist well-developed epidermal ridges, to which are attached one or two ducts of sweat glands. a thick stratum corneum can be seen in the epidermis, while a distinct stratum lucidum cannot be isolated from the other layers. the stratum granulosum is constituted by one or three layers of cells containing keratohyalin ...1976823786
the reproductive potential of the common cotton-eared marmoset (callithrix jacchus) in captivity.the breeding records of a closed colony of marmosets maintained for five years are described. three generations have been born and a high incidence of multiparity has been achieved. the reproductive potential of c. jacchus is higher than that of virtually any other primate maintained in captivity.1976818387
histochemical studies on the adrenal glands of the marmosets (callithrix jacchus and callithrix penicillata).the histrochemistry of the adrenal glands was studied in four adult male marmosets (two callithrix jacchus and two callithrix penicillata). it was impossible to demonstrate any reactivity to udpg-gt, adh, alanyl aminopeptidase, leucine aminopeptidase, xilitol (nad-dependent) dehydrogenase, beta-glucuronidase and aryl-sulfatase in these glands. total phosphorylase was found in scattered cells of the glomerulosa and adjacent outer fasciculata of one c. penicillata. the dehydrogenases (ldh, g-6-pdh ...19768944
reproduction of wild-caught and laboratory-born marmoset species used in biomedical research (saguinus sp, callithrix jacchus).reproductive performances of wild-caught and laboratory-born marmosets maintained in a paired-cage system were summarized. wild-caught, white-lipped (wl) marmosets (saguinus fuscicollis, s nigricollis) averaged 2.6 live births per pair per yr compared with 1.6 for cotton-topped (ct) marmosets (s oedipus); s fuscicollis illigeri pairs were the best producers. of first and second generation laboratory-born animals, crossbred or hybrid wl pairs were the best producers; first generation pairs averag ...1975813062
thalamic and other subcortical projections to area mt (visual area of superior temporal sulcus) in the marmoset callithrix jacchus. 1975810924
abnormal fetal development in the marmoset (callithrix jacchus). 1975808604
some aspects of sexuality and reproduction in groups of captive marmosets (callitbrix jacchus).several aspects of sexual and reproductive behaviour of callithrix jacchus were studied for almost five years. the most important results are as follows: (1) in artificial groups (ag), heterosexual interactions were observed with varying frequencies between all group members; in the family groups (fg), however only between the parents (a-male and a-female). (2) in general, sexual interactions between two animals in the ag were tolerated by the other group members; in the fg, the offspring tried ...1975821267
management of marmosets for biomedical research.the management of a successful breeding colony of common marmosets, callithrix jacchus, is described, including details of treatment during the conditioning period after arrival from the wild. methods are described for the collection of blood, urine, and vaginal washings. suggestions are made for improving the conditions of importation of these animals from south america.1975806744
prealbumins in the vaginal flushings of the marmoset, callithrix jacchus. 1975805235
the use of transabdominal palpation to determine the course of pregnancy in the marmoset (callithrix jacchus).transabdominal palpation was used to determine maturity, course of pregnancy and post-partum changes in marmosets throughout seventy-four full-term pregnancies. the accuracy of the technique is compared with that of other methods of studying the course of pregnancy in this species.1975805234
periodontal changes in distant teeth due to trauma from occlusion.the present investigation studies the changes that occur in periodontal supporting tissues of lower canine and premolar of marmosets (callithrix jacchus), due to experimental modification of occlusal relationships in the region of the molar. for our purposes an extracoronal arch wire of 0.7 mm diameter was fixed into occlusal perforations of the upper third premolar and first molar, on both sides. eight male marmosets weighing from 250 to 350 grams were used. after each experimental time interva ...1975124334
[observations, analyses and experiments on the use of the hand in callithrix jacchus erxleben, 1777. part ii. fine analysis of prehensive behavior].the use of the hand of the common marmoset (callithrix jacchus erxleben, 1777) was analysed on the basis of observations and experiments conducted on 56 animals of all age. during arboreal locomotion callithrix jacchus makes use of the hands for support and for grasping to maintain its balance, the palmar region serves as the main means of support, while the findgers in the locomotor grip also contribute to maintaining balance and support. the greater the need for maintaining balance, for exampl ...1975814031
[studies, analyses and experiments on the use of the hand of callithrix jacchus erxleben 1777. i. locomotion behavior]. 1975811499
clinical use of ct1341 anaesthetic ("saffan") in marmosets (callithrix jacchus).an intramuscular dose of 18 mg/kg bodyweight of this steroid anaesthetic produced surgical anaesthesia with rapid induction, safe, efficient maintenance and rapid recovery without side effects.1975804073
diagnosis of pregnancy in marmosets (callithrix jacchus).3 techniques for studying reproductive function in the marmoset are described. abdominal palpation was found to be the most successful method for diagnosis of pregnancy. vaginal cytology and urinary immunoassays met with limited success and were of supportive value only.1975804072
histochemical localization of enzyme activity in the kidneys of male marmosets (callithrix jacchus and callithrix penicillata).the distribution of several hydrolases and oxidoreductases was studied in the renal parenchyma of adult male marmosets (callithrix jacchus and callithrix penicillata). the oxidative enzymes showed a high reactivity in the proximal and distal tubules, whereas the hydrolases reacted strongly in the proximal tubules but only weakly or not at all in the thick limb of henle's loop, distal tubules and collecting ducts. the nad-dependent enzymes (except alpha-gpdh) showed a stronger reactivity in the p ...1975169663
progesterone and oestrogen metabolism in the pregnant marmoset (callithrix jacchus). 19744214968
latent infection and malignant lymphoma in marmosets (callithrix jacchus) after infection with two oncogenic herpesviruses from primates. 19744365908
histochemical data on the aorta of marmosets (callithrix jacchus and callithrix penicillata). 19744276774
[serum proteins and red cell enzymes in callithrix jacchus (author's transl)]. 19744219869
repair of the post-extraction sockets in marmosets (callithrix jacchus). 19744218706
changes in aortic medial elastic structure at different sites in the primates erythrocebus patas, macaca irus and callithrix jacchus. 19734201087
[observations on the delivery behaviour in the common marmoset (callithrix jacchus erxleben, 1777) (author's transl)]. 19734203260
handedness in the common marmoset (callithrix jacchus). 19734632104
[elastic fibers distribution in the disc of the temporormandibular joint of the marmoset (callithrix jacchus l. 1758)]. 19734197801
experimental-anatomical studies on the "middle temporal visual area (mt)" in primates. i. efferent cortico-cortical connections in the marmoset callithrix jacchus. 19724628544
[angioarchitectonics of the rhombencephalon and cerebellum. vi. leptomeningeal vessels in callithrix jacchus (linné, 1758)]. 19724632871
structure and distribution of polysaccharides in the salivary glands of the common marmoset (callithrix jacchus). 19724625919
data on the structure and distribution of polysaccharides in the lacrimal glands of the common marmoset (callithrix jacchus). 19724265832
[toxoplasmosis in nonhuman primates. ii. attempts at experimental infection in macacca mulata, cebus apella and callithrix jacchus; and search for antibodies in several species of platyrrhinus]. 19715002530
the eccrine sweat glands of the palms and soles of the common marmoset (callithrix jacchus). 19714332587
histochemical data on the sebaceous glands in the lips of the marmoset (callithrix jacchus). 19714325117
[hybridism between callithrix jacchus (l., 1758) x c. geoffroyi (humboldt, 1812) (callithricidae, primates)]. 19705521414
quantitative studies on scent marking in the marmoset (callithrix jacchus). 19704988037
the male reproductive system of the common marmoset (callithrix jacchus). 19704251244
chorionic gonadotropin excretion during pregnancy in the marmoset, callithrix jacchus. 19694977682
histopathology of experimentally induced nutritional deficiency cheilosis in the marmoset (callithrix jacchus). 19694980011
the meibomian glands of the marmoset (callithrix jacchus). 19694986924
the adrenal cortex of the marmoset. (callithrix jacchus). 19694241965
[an unrestricted marmoset (callithrix jacchus) perceives pictures]. 19684972844
data on the kidneys of the marmoset (callithrix jacchus). 19684233484
[on the presence of acid phosphatase in the pyloric glands of the marmoset (callithrix jacchus)]. 20005236327
histological and histochemical data on the intestinal tract of the marmoset. (callithrix jacchus). 19674232561
chromosome analysis of four species of marmosets (callithrix jacchus, tamarinus mystax, tamarinus nigricollis, cebuella pygmaea). 19664959871
[the gingiva of the marmoset. (callithrix jacchus)]. 20034957601
histochemical studies on the adrenal medullary cells of the marmoset (callithrix jacchus). 20174221954
[present aspects of structure and histochemistry of the stomach of the marmoset (callithrix jacchus)]. 20144955660
[distribution of the mast cells in the organs of marmoset (callithrix jacchus)]. 200614091851
[contribution to the histological and histochemical study of the teeth of the marmoset callithrix jacchus (linnaeus 1866)]. 200614091850
the renewal of gingival epithelium in marmosets (callithrix jacchus) as determined through autoradiography with thymidine-h3. 196213989107
marrow chimerism in marmosets.in the femoral marrow of three adult marmosets, two male callithrix jacchus and one female leontocebus rosalia, a number of opposite-sexed metaphases were found. it is inferred that this chimeric state resulted from intrauterine placental anastomoses between heterosexual twins. the lack of the freemartin effect in connection with this chimerism is discussed, and the structural nature of the y chromosome in the callithricidae is described.196217753948
[natural infection of the saki callithrix jacchus by cruzi type trypanosoma]. 200614026153
[distribution of pas-positive substances and of alkaline phosphomonoesterases in the tissues of the "sagui" (callithrix jacchus)]. 201614474409
[notes on the structure and vascularization of the hypophysis of the "marmoset" (callithrix jacchus)]. 200613771154
human neutralizing monoclonal antibody efficiently inhibits mers-cov replication in common marmoset.middle east respiratory syndrome coronavirus (mers-cov) infection in humans is highly lethal, with a fatality rate of 35%. new prophylactic and therapeutic strategies to combat human infections are urgently needed. we isolated a fully human neutralizing antibody, mca1, from a human survivor. the antibody recognizes the receptor-binding domain of mers-cov s glycoprotein and interferes with the interaction between viral s and the human cellular receptor human dipeptidyl peptidase 4 (dpp4). to our ...201728472421
mers coronavirus induces apoptosis in kidney and lung by upregulating smad7 and fgf2.middle east respiratory syndrome coronavirus (mers-cov) causes sporadic zoonotic disease and healthcare-associated outbreaks in human. mers is often complicated by acute respiratory distress syndrome (ards) and multi-organ failure(1,2). the high incidence of renal failure in mers is a unique clinical feature not often found in other human coronavirus infections(3,4). whether mers-cov infects the kidney and how it triggers renal failure are not understood(5,6). here, we demonstrated renal infecti ...201627572168
a comparative review of animal models of middle east respiratory syndrome coronavirus infection.middle east respiratory syndrome coronavirus (mers-cov) was initially isolated from a saudi arabian man with fatal pneumonia. since the original case in 2012, mers-cov infections have been reported in >1500 humans, and the case fatality rate is currently 35%. this lineage c betacoronavirus has been reported to cause a wide range of disease severity in humans, ranging from asymptomatic to progressive fatal pneumonia that may be accompanied by renal or multiorgan failure. although the clinical pre ...201626869154
intratracheal exposure of common marmosets to mers-cov jordan-n3/2012 or mers-cov emc/2012 isolates does not result in lethal disease.middle east respiratory syndrome coronavirus (mers-cov) continues to be a threat to human health in the middle east. development of countermeasures is ongoing; however, an animal model that faithfully recapitulates human disease has yet to be defined. a recent study indicated that inoculation of common marmosets resulted in inconsistent lethality. based on these data we sought to compare two isolates of mers-cov. we followed disease progression in common marmosets after intratracheal exposure wi ...201526342468
middle east respiratory syndrome coronavirus efficiently infects human primary t lymphocytes and activates the extrinsic and intrinsic apoptosis pathways.middle east respiratory syndrome (mers) is associated with a mortality rate of >35%. we previously showed that mers coronavirus (mers-cov) could infect human macrophages and dendritic cells and induce cytokine dysregulation. here, we further investigated the interplay between human primary t cells and mers-cov in disease pathogenesis. importantly, our results suggested that mers-cov efficiently infected t cells from the peripheral blood and from human lymphoid organs, including the spleen and th ...201626203058
occurrence of hemotropic mycoplasmas in non-human primates (alouatta caraya, sapajus nigritus and callithrix jacchus) of southern brazil.hemoplasmas, the erythrocyte-associated mycoplasmas, have been detected in several primates, causing mostly subclinical infection. this study aimed to determine the prevalence of hemoplasma infection in captive and free-ranging monkeys from southern brazil, as well as factors and hematological abnormalities associated with infection. blood samples from 40 non-human primates (nhp) were tested for hemoplasmas and coinfections. an overall of 10/40 (25.0%) nhp tested positive for hemoplasmas using p ...201728673463
identification and characterization of a subtelomeric satellite dna in callitrichini monkeys.repetitive dnas are abundant fast-evolving components of eukaryotic genomes, which often possess important structural and functional roles. despite their ubiquity, repetitive dnas are poorly studied when compared with the genic fraction of genomes. here, we took advantage of the availability of the sequenced genome of the common marmoset callithrix jacchus to assess its satellite dnas (satdnas) and their distribution in callitrichini. after clustering analysis of all reads and comparisons by sim ...201728854689
thorny ganglion cells in marmoset retina: morphological and neurochemical characterization with antibodies against calretinin.in primates over 17 morphological types of retinal ganglion cell have been distinguished by their dendritic morphology and stratification, but reliable markers for specific ganglion cell populations are still rare. the calcium binding protein calretinin is known to be expressed in the inner nuclear and the ganglion cell layer of marmoset retina, however, the specific cell type(s) expressing calretinin in the ganglion cell layer are yet to be determined. here we identified calretinin positive ret ...201728875500
silencing of fus in the common marmoset (callithrix jacchus) brain via stereotaxic injection of an adeno-associated virus encoding shrna.fused in sarcoma (fus) is an rna binding protein that is involved in frontotemporal lobar degeneration (ftld) and amyotrophic lateral sclerosis (als). to establish the common marmoset (callithrix jacchus) as a model for ftld, we generated a stereotaxic injection-based marmoset model of fus-silencing. we designed shrnas against the marmoset fus gene and generated an aav9 virus encoding the most effective shrna against fus (shfus). the aav encoding shfus (aav-shfus) was introduced into the frontal ...201728842245
different methods for volatile sampling in mammals.previous studies showed that olfactory cues are important for mammalian communication. however, many specific compounds that convey information between conspecifics are still unknown. to understand mechanisms and functions of olfactory cues, olfactory signals such as volatile compounds emitted from individuals need to be assessed. sampling of animals with and without scent glands was typically conducted using cotton swabs rubbed over the skin or fur and analysed by gas chromatography-mass spectr ...201728841690
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