| synthesis and pharmacological evaluation of schiff bases of 4-(2-aminophenyl)-morpholines. | in the present study, a novel series of 4-(2-aminophenyl)morpholines were synthesized and characterized by ir, (1)h-nmr, (13)c nmr and mass spectral analysis. the synthesized compounds were screened for analgesic (100 and 200 mg/kg), antiinflammatory (200 and 400 mg/kg), antibacterial (bacillus subtilis, bacillus cereus, staphylococcus epidermidis, staphylococcus aureus, klebsiella pneumoniae, pseudomonas aeruginosa and escherichia coli) and antifungal (candida albicans and aspergillus niger) ac ... | 2009 | 20502549 |
| antibiotic pigment from desert soil actinomycetes; biological activity, purification and chemical screening. | an actinomycete strain, streptomyces hygroscopicus subsp. ossamyceticus (strain d10) was isolated from thar desert soil, rajasthan during the year 2006 and found to produce a yellow color pigment with antibiotic activity. crude pigment was produced from strain d10 by solid state fermentation using wheat bran medium followed by extraction with ethyl acetate. the antimicrobial activity of the crude pigment was evaluated against drug resistant pathogens such as methicillin-resistant staphylococcus ... | 2009 | 20502566 |
| antimicrobial activity of hemidesmus indicus, ficus bengalensis and pterocarpus marsupium roxb. | the antimicrobial activity of hemidesmus indicus, ficus bengalensis and pterocarpus marsupium roxb was evaluated against pathogenic bacteria stahylococcus aureus, pseudomonas aeruginosa and klebsiella pneumonia in an in vitro condition. aqueous extracts from roots of h. indicus and barks of f. bengalensis and p. marspium roxb were tested for antimicrobial activity using the zone of inhibition method and also screened for phytochemicals. the aqueous extract of p. marsupium roxb inhibited growth o ... | 2009 | 20502584 |
| pyogenic liver abscess: differences in etiology and treatment in southeast asia and central europe. | knowledge of etiology and timely treatment of underlying causes, when possible, play an important role in the successful therapy of patients with pyogenic liver abscess (pla). recent publications from central europe and southeast asia hint at considerable differences in etiology. in this article, we aim to elaborate these differences and their therapeutic implications. apart from some special types of pla that are comparable in southeast asia and central europe (such as posttraumatic or postproc ... | 2010 | 20503444 |
| antimicrobial resistant bacteria among health care workers in intensive care units at ain shams university hospitals. | fifty hcws in icus of internal medicine, chest, neonatology and burn were included in prospective cohort study. collection of nasal, hand and rectal swabs, proper biochemical identification, culture media and antibiotic sensitivity tests were used to detect methicillin-resistant staphylococcus aureus (mrsa); vancomycin-resistant enterococci (vre) & extended spectrum beta-lactamase producing gram -ve bacilli (esbls). s. aureus was isolated from 34% of hcws; 28% were nasal carriers, 4% were hand c ... | 2010 | 20503587 |
| characteristics of meropenem heteroresistance in klebsiella pneumoniae carbapenemase (kpc)-producing clinical isolates of k. pneumoniae. | meropenem heteroresistance was investigated in six apparently meropenem-susceptible, klebsiella pneumoniae carbapenemase (kpc)-producing k. pneumoniae (kpc-kp) clinical isolates, compared with that in carbapenemase-negative, meropenem-susceptible controls. in population analyses, the kpc-kp isolates grew at meropenem concentrations of 64 to 256 microg/ml. heteroresistant colonies had significantly elevated expression of the bla(kpc) gene compared with the native populations but did not retain he ... | 2010 | 20504985 |
| predictors, treatment, and outcomes of non-pseudomonas gram-negative peritonitis. | non-pseudomonas gram-negative (npgn) peritonitis is a frequent, serious complication of peritoneal dialysis; however, previous reports have been limited to small, single-center studies. to gain insight on the frequency, predictors, treatment, and outcomes of npgn peritonitis, we analyzed data in the anzdata registry of all adult australian peritoneal dialysis patients over a 39-month period using multivariate logistic and multilevel poisson regressions. there were 837 episodes of npgn peritoniti ... | 2010 | 20505659 |
| clinical and microbiological characteristics of community-acquired thoracic empyema or complicated parapneumonic effusion caused by klebsiella pneumoniae in taiwan. | klebsiella pneumoniae is the major cause of community-acquired pyogenic infections in taiwan and is becoming an increasing problem in acute thoracic empyema. this study evaluated the clinical and microbiological characteristics of community-acquired thoracic empyema or complicated parapneumonic effusion caused by k. pneumoniae in taiwanese adults treated during the period 2001-2008 at a tertiary medical center. all clinical isolates were examined for capsular serotypes k1/k2, and pulsed-field ge ... | 2010 | 20505967 |
| [change in distribution of pathogens and nosocomial antibiotic resistant gram-negative bacilli infection in intensive care units one month after an earthquake]. | to investigate the change in distribution of pathogens and nosocomial antibiotic resistant gram-negative bacilli infection in intensive care units one month after an earthquake. | 2010 | 20506662 |
| spread of oxa-48-mediated resistance to carbapenems in lebanese klebsiella pneumoniae and escherichia coli that produce extended spectrum beta-lactamase. | | 2010 | 20507701 |
| transfer of carbapenem-resistant plasmid from klebsiella pneumoniae st258 to escherichia coli in patient. | klebsiella pneumoniae carbapenemase (kpc) 3-producing escherichia coli was isolated from a carrier of kpc-3-producing k. pneumoniae. the kpc-3 plasmid was identical in isolates of both species. the patient's gut flora contained a carbapenem-susceptible e. coli strain isogenic with the kpc-3-producing isolate, which suggests horizontal interspecies plasmid transfer. | 2010 | 20507761 |
| extended spectrum beta-lactamase producing escherichia coli and klebsiella pneumoniae isolated in a rural hospital. | extended spectrum beta-lactamase (esbl) producing strains pose greatest therapeutic challenge and have been reported as emerging pathogens causing nosocomial infection. the present study was undertaken to detect the esbl producing esch coli and klebsiella pneumoniae strains, which were screened to detect esbl production. a total number of 320 e. coli and klebsiella pneumoniae strains were processed in the microbiology department. antibiotic sensitivity test with ciprofloxacin, amikacin, cefotaxi ... | 2009 | 20509468 |
| the ongoing challenge of acquired carbapenemases: a hospital outbreak of klebsiella pneumoniae simultaneously producing vim-1 and kpc-2. | | 2010 | 20510588 |
| role of mrkj, a phosphodiesterase, in type 3 fimbrial expression and biofilm formation in klebsiella pneumoniae. | klebsiella pneumoniae is an opportunistic pathogen that has been shown to adhere to human extracellular matrices using the type 3 fimbriae. introduction of plasmids carrying genes known to alter intracellular cyclic-di-gmp pools in vibrio parahaemolyticus revealed that these genes also altered type 3 fimbrial surface expression in k. pneumoniae. immediately adjacent to the type 3 fimbrial gene cluster is a gene, mrkj, that is related to a family of bacterial genes encoding phosphodiesterases. we ... | 2010 | 20511505 |
| susceptibility of klebsiella spp. to tigecycline and other selected antibiotics. | tigecycline is a new glycylcycline with broad-spectrum activity. among these new agents, tigecycline is unique in generally having good activity against gram-negative bacteria. tigecycline has been approved for the treatment of complicated intra-abdominal infections and complicated skin and skin structure infections. tigecycline had good activity against most esbl-producing enterobacteriaceae and may be a therapeutic alternative to carbapenems in some infections caused by esbl-producing isolates ... | 2010 | 20512088 |
| carbapenem-resistant acinetobacter baumannii and klebsiella pneumoniae across a hospital system: impact of post-acute care facilities on dissemination. | resistance to carbapenems among acinetobacter baumannii and klebsiella pneumoniae presents a serious therapeutic and infection control challenge. we describe the epidemiology and genetic basis of carbapenem resistance in a. baumannii and k. pneumoniae in a six-hospital healthcare system in northeast ohio. | 2010 | 20513702 |
| emergence of bla kpc-3-tn4401a associated with a pkpn3/4-like plasmid within st384 and st388 klebsiella pneumoniae clones in spain. | kpc carbapenemase-producing klebsiella pneumoniae isolates have been increasingly detected in europe. we report the first kpc-producing isolates characterized in madrid, spain. | 2010 | 20513703 |
| most frequent causes of urinary tract infections in children. | to determine the most frequent causes of urinary tract infection (uti) amongst children according to gender and age. | 2010 | 20514772 |
| a mimicry of melioidosis by klebsiella ozaenae infection. | klebsiella ozaenae is a gram negative bacillus. it has been described as a colonizer of oral and nasopharyngeal mucosa and is a cause of atrophic rhinitis. klebsiella ozaenae has seldom been isolated from serious infections. however, several reports have stated that klebsiella ozaenae may cause invasive infections and even mortality. we report a 55-year-old man with klebsiella ozaenae infection causing abscesses involving the right eye and left kidney and possibly also in the brain, lungs and pr ... | 2009 | 20514860 |
| migrated foreign body liver abscess: illustrative case report, systematic review, and proposed diagnostic algorithm. | pyogenic liver abscess is a severe condition and a therapeutic challenge. treatment failure may be due to an unrecognized ingested foreign body that migrated from the gastrointestinal tract. there has recently been a marked increase in the number of reported cases of this condition, but initial misdiagnosis as cryptogenic liver abscess still occurs in the majority of cases. we conducted the current study to characterize this entity and provide a diagnostic strategy applicable worldwide. to this ... | 2010 | 20517180 |
| the impact of fluoroquinolones use on antibiotic resistance in an intensive care burn department. | fluoroquinolones (fq) use has been identified as a risk factor for colonization and infection to methicillin resistant staphylococcus aureus(mrsa), pseudomonas aeruginosae multiresistant(pmr) , acinetobacter multiresistant (amr) and multidrug resistant bacteria(mdrb). | 2010 | 20517823 |
| rapid reporting of urine culture results: impact of the uro-quick screening system. | this study evaluated the impact of the uro-quick (uq) screening system (alifax, italy) for a rapid and accurate reporting of urine cultures, and whether it can provide bacterial yield to be used in identification and susceptibility testing. a total of 1480 urine samples collected between october 2006 and july 2008 were tested by conventional culture (cc) methods and uq simultaneously. sediments of positive uq vials were used as bacterial yields for identification and susceptibility testing proce ... | 2010 | 20518276 |
| evidence to support the therapeutic potential of bacteriophage kpn5 in burn wound infection caused by klebsiella pneumoniae in balb/c mice. | the emergence of antibiotic-resistant bacterial strains is one of the most critical problems of modern medicine. bacteriophages have been suggested as an alternative therapeutic agent for such bacterial infections. in the present study, we examined the therapeutic potential of phage kpn5 in the treatment of klebsiella pneumoniae b5055-induced burn wound infection in a mouse model. an experimental model of contact burn wound infection was established in mice employing k. pneumoniae b5055 to asses ... | 2010 | 20519918 |
| activity of doripenem against extended-spectrum beta-lactamase-producing enterobacteriaceae and pseudomonas aeruginosa isolates. | the in vitro activity of doripenem was evaluated against a recent collection of extended-spectrum beta-lactamase (esbl)-producing enterobacteriaceae and pseudomonas aeruginosa isolates (201 esbl-producing enterobacteriaceae [153 escherichia coli and 48 klebsiella pneumoniae] and 201 p. aeruginosa). comparator agents included amikacin, tobramycin, ciprofloxacin, cefepime, cefotaxime, ceftazidime piperacillin-tazobactam, imipenem, and meropenem. both doripenem and meropenem inhibited 100% of the e ... | 2010 | 20521156 |
| antimicrobial susceptibility of gram-negative nonurinary bacteria to fosfomycin and other antimicrobials. | fosfomycin is an antimicrobial commonly used in uncomplicated urinary tract infections. the microbiological effectiveness of fosfomycin against nonurinary gram-negative isolates has not been widely investigated. the aim of this study was to evaluate the in vitro activity of fosfomycin against gram-negative nonurinary isolates in a region of greece where considerable antimicrobial resistance has been detected. | 2010 | 20521939 |
| detection of the new metallo-beta-lactamase vim-19 along with kpc-2, cmy-2 and ctx-m-15 in klebsiella pneumoniae. | to report the identification of the metallo-beta-lactamase (mbl) variant vim-19 in a klebsiella pneumoniae clinical strain co-producing kpc-2 carbapenemase, cmy-2 cephalosporinase and ctx-m-15 extended-spectrum beta-lactamase. | 2010 | 20522444 |
| asymmetrical distribution of the second messenger c-di-gmp upon bacterial cell division. | the bacterial second messenger cyclic diguanosine monophosphate (c-di-gmp) regulates cellular motility and the synthesis of organelles and molecules that promote adhesion to a variety of biological and nonbiological surfaces. these properties likely require tight spatial and temporal regulation of c-di-gmp concentration. we have developed genetically encoded fluorescence resonance energy transfer (fret)-based biosensors to monitor c-di-gmp concentrations within single bacterial cells by microsco ... | 2010 | 20522779 |
| [etiologic factors in urinary tract infection investigated in ambulatory setting. community-acquired urinary tract infection: etiologic aspects and antibiotic resistance]. | urine bacteriological examination is one of the most frequently asked for examinations, in ambulatory as well as in hospitals, regarding specialty prophyle. the present study comprises a group of 3971 pacients that were sent to the laboratory for uroculture and showed a percentage of only 21.85% significant urocultures--the etiological groups most frequently isolated being gram-negative bacilli--96.05%, respectively escherichia sp. 76.95%, klebsiella sp. 14.68%, proteus sp. 4.66%. out of the gra ... | 2009 | 20524391 |
| pattern of pathogens and their sensitivity isolated from superficial surgical site infections in a tertiary care hospital. | infection is an important cause of morbidity and mortality in surgical patients. rapidly emerging nosocomial pathogens and the problem of multi-drug resistance necessitates periodic review of isolation patterns and sensitivity in surgical practice. surgical site infections (ssi) are defined as an infections that occurs at the incision site within thirty days after surgery. objectives of the study were to determine the pattern of pathogens involved and their antibiotic sensitivity isolated from s ... | 2009 | 20524476 |
| bacterial pneumonia following cytotoxic chemotherapy for lung cancer: clinical features, treatment outcome and prognostic factors. | data regarding treatment outcomes and prognosis in pneumonia that occurs after lung cancer chemotherapy are lacking. we performed a retrospective study of 84 patients with clinically suspected bacterial pneumonia after cytotoxic chemotherapy for lung cancer. small cell carcinoma was the most common histological type (36.9%, n = 31), followed by squamous cell carcinoma (35.7%, n = 30) and adenocarcinoma (21.4%, n = 18). the most frequent pathogen was streptococcus pneumoniae (n = 14), followed by ... | 2010 | 20524784 |
| development of high-level carbapenem resistance in klebsiella pneumoniae among patients with prolonged hospitalization and carbapenem exposure. | an increasing incidence of carbapenem-resistant klebsiella pneumoniae (crkp) infections has been reported worldwide. the aim of this study was to investigate the mechanism underlying carbapenem resistance and its relationship to antibiotic exposure. sixteen isolates with various carbapenem susceptibilities recovered from five patients between 2003 and 2006 were subjected to molecular study. the medical records of the patients were also reviewed. all of the patients were admitted for complicated ... | 2010 | 20524901 |
| [immunization and bacterial pathogens in the oropharynx as risk factors for alopecia areata]. | alopecia areata is an autoimmune inflammatory disease affecting the hair follicles. researchers are currently interested in whether the presence of bacterial pathogens and/or a history of immunization can trigger an autoimmune response in patients who are genetically predisposed. | 2010 | 20525487 |
| antibiotic resistance patterns and detection of bladha-1 in salmonella species isolates from chicken farms in south korea. | fifteen nonrepetitive ampicillin-resistant salmonella spp. were identified among 91 salmonella sp. isolates during nationwide surveillance of salmonella in waste from 131 chicken farms during 2006 and 2007. additional phenotyping and genetic characterization of these 15 isolates by using indicator cephalosporins demonstrated that resistance to ampicillin and reduced susceptibility to cefoxitin in three isolates was caused by tem-1 and dha-1 beta-lactamases. plasmid profiling and southern blot an ... | 2010 | 20525869 |
| antibacterial activity of zno nanoparticles prepared via non-hydrolytic solution route. | the antibacterial activity of zno nanoparticles has been investigated and presented in this paper. nanoparticles were prepared via non-hydrolytic solution process using zinc acetate di-hydrate (zn(ch(3)coo)(2).2h(2)o) and aniline (c(6)h(5)nh(2)) in 6 h refluxing at approximately 65 degrees c. in the presence of four pathogens such as staphylococcus aureus, escherichia coli, salmonella typhimurium, and klebsiella pneumoniae, the antibacterial study of zinc oxide nanoparticles were observed. the a ... | 2010 | 20526594 |
| indole-3-acetic acid (iaa) production in symbiotic and non-symbiotic nitrogen-fixing bacteria and its optimization by taguchi design. | production of indole-3-acetic acid (iaa) in 35 different symbiotic and non-symbiotic nitrogen-fixing bacteria strains isolated from soil and plant roots was studied and assayed by chromatography and colorimetric methods. these bacteria included agrobacterium, paenibacillus, rhizobium, klebsiella oxytoca, and azotobacter. the best general medium and synergism effects of isolates for iaa production were investigated. effects of different variables containing physical parameters and key media compo ... | 2010 | 20526603 |
| isolation and characterization of klebsiella pneumoniae specific bacteriophages from sewage samples. | five bacteriophages (kpn5, kpn12, kpn13, kpn17 and kpn22), each having specificity against klebsiella pneumoniae strain b5055, were isolated from sewage samples and characterized in terms of growth characteristics, genetic material, morphology and structural proteins. adsorption rate as well as single step growth curve experiments showed variation among phages. restriction enzyme digestion of dna confirmed the presence of double stranded dna as well as the heterogeneous nature of genetic materia ... | 2010 | 20526833 |
| [clinical assessment of novel chromid esbl agar plates for detection of esbl producers in the family enterobacteriaceae]. | extended-spectrum beta-lactamase (esbl)-producers in the family enterobacteriaceae are recognized worldwide as nosocomial pathogens, however it is difficult to screen them in the routine laboratory processing. chromid esbl agar newly developed for screening esbl-producing enterobacteriaceae was released in japan in april, 2007. we evaluated the clinical assessment of chromid esbl agar in routine microbiology laboratory. the 47 strains investigated were clinical isolates belonging to the family e ... | 2009 | 20528091 |
| detection of a common plasmid carrying blakpc-2 in enterobacteriaceae isolates from distinct cities in china. | four isolates of klebsiella pneumoniae and one isolate of enterobacter cloacae exhibiting resistance to most β-lactam antibiotics, including oxyimino-cephalosporins and carbapenems, were obtained from different patients among four hospitals in china. pulsed-field gel electrophoresis demonstrated that all the k. pneumoniae isolates belonged to two clone patterns. multilocus sequence typing showed that the four isolates of k. pneumoniae belonged to two sequence types: st 23 and st 351. conjugation ... | 2010 | 20528100 |
| carbapenem-nonsusceptible strains of klebsiella pneumoniae producing shv-5 and/or dha-1 beta-lactamases in a czech hospital. | resistance to carbapenems in enterobacteria is mediated by the production of several types of carbapenemases or by the decreased permeability of the outer membrane, combined with the expression of extended-spectrum beta-lactamases (esbls) or ampc-like cephalosporinases. the objective of this study was to characterize carbapenem-nonsusceptible (c-ns) isolates of klebsiella pneumoniae in the university hospital in plzen (czech republic) and compare them with carbapenem-susceptible (c-s) k. pneumon ... | 2010 | 20528936 |
| warfarin-induced skin necrosis in hiv-1-infected patients with tuberculosis and venous thrombosis. | at the turn of the century, only 300 cases of warfarin-induced skin necrosis (wisn) had been reported. wisn is a rare but potentially fatal complication of warfarin therapy. there are no published reports of wisn occurring in patients with hiv-1 infection or tuberculosis (tb). | 2010 | 20529438 |
| mutagenesis of klebsiella aerogenes ureg to probe nickel binding and interactions with other urease-related proteins. | ureg is a gtpase required for assembly of the nickel-containing active site of urease. herein, a strep-tagged klebsiella aerogenes ureg (ureg(str)) and selected site-directed variants of ureg(str) were constructed for studying the in vivo effects on urease activation in recombinant escherichia coli cells, characterizing properties of the purified proteins, and analysis of in vivo and in vitro protein-protein interactions. whereas the strep tag had no effect on ureg's ability to activate urease, ... | 2010 | 20533838 |
| the effect of hydrolysis degree on the properties of antibacterial polymeric films based on poly(vinyl alcohol) and zinc sulphate for biomedical applications. | fully and partially hydrolyzed poly(vinyl alcohol) (pva) was modified with zinc sulphate in the concentration range from 0 to 9 wt% of recalculated zinc content using the solvent cast technique. the resulting polymeric films were characterized by optical microscopy, stress-strain analysis, differential scanning calorimetry and fourier transform infrared spectroscopy (ft-ir-atr). in addition, agar diffusion test and dilution and spread plate technique were used for determination of antibacterial ... | 2010 | 20534194 |
| the association between antibiotic use and resistance: the role of secondary antibiotics. | using susceptibility rates of pseudomonas aeruginosa, escherichia coli, klebsiella pneumoniae, and enterobacter cloacae over time as markers, we assessed the significance of the change of susceptibility rates to imipenem, ceftriaxone, cefepime, piperacillin/tazobactam, and ciprofloxacin over time and the relationship to antibiotic use for the period 2000-2006. antibiotic use-susceptibility relationships were assessed using longitudinal regression analysis. the variables "time" and define daily d ... | 2010 | 20535624 |
| new quinoline derivatives: synthesis and investigation of antibacterial and antituberculosis properties. | four new series of quinoline derivatives were synthesized starting from 2-trifluoromethyl aniline through multi-step reactions. in the reaction sequence, substituted aniline was cyclized to 4-hydroxy quinoline 1, which was then transformed to 4-chloro-2,8-bis(trifluoromethyl)quinoline 2. the key scaffold 4-hydrazinyl-2,8-bis(trifluoromethyl)quinoline 3, obtained from the compound 2, was successfully converted to target quinoline derivatives, viz. hydrazones 4a-t, ureas 5a-e, thioureas 6a-c and p ... | 2010 | 20537437 |
| resistance to cephalosporins and carbapenems in gram-negative bacterial pathogens. | during the past 15 years, emergence and dissemination of beta-lactam resistance in nosocomial enterobacteriaceae, pseudomonas aeruginosa and acinetobacter baumannii, became a serious problem worldwide. especially the increasing resistance to 3rd and 4th generation cephalosporins and carbapenems is of particular concern. gram-negative bacteria pursue various molecular strategies for development of resistance to these antibiotics: (a) generation of extended-spectrum beta-lactamases (esbl) accordin ... | 2010 | 20537585 |
| solution structure and phospho-pmra recognition mode of pmrd from klebsiella pneumoniae. | in bacteria, the two-component system (tcs) is the most prevalent for sensing and transducing the environmental signals into the cell. in salmonella, the small basic protein pmrd is found to protect phospho-pmra and prolong the expression of pmra-activated genes. in contrast, escherichia coli pmrd fails to protect phospho-pmra. here, we show that klebsiella pneumoniae pmrd (kp-pmrd) can inhibit the dephosphrylation of phospho-pmra, and the interaction between kp-pmrd and the n-terminal receiver ... | 2010 | 20538060 |
| copper(ii) and nickel(ii) complexes of benzyloxybenzaldehyde-4-phenyl-3-thiosemicarbazone: synthesis, characterization and biological activity. | benzyloxybenzaldehyde-4-phenyl-3-thiosemicarbazone ligand (l) has been synthesized from benzyloxybenzaldehyde and 4-phenyl-3-thiosemicarbazide. complexes of this ligand with chlorides of cu(ii) and ni(ii) have been prepared. the structure of the ligand (l) is proposed based on elemental analysis, ir and (1)h nmr spectra. its complexes with cu(ii) and ni(ii) ions are characterized from the studies of electronic as well as epr spectra. on the basis of electronic and epr studies, rhombically distor ... | 2010 | 20538508 |
| risk factors for late onset gram-negative infections: a case-control study. | to determine the incidence, mortality and risk factors for neonatal late onset gram-negative sepsis and meningitis (logns). | 2011 | 20538712 |
| antibiotic susceptibility of intra-abdominal infection isolates from indian hospitals during 2008. | a total of 542 clinical isolates of aerobic gram-negative bacilli from intra-abdominal infections were collected during 2008 from seven hospitals in india participating in the study for monitoring antimicrobial resistance trends (smart). isolates were from various infection sources, the most common being gall bladder (30.1 %) and peritoneal fluid (31.5 %), and were mostly hospital-associated isolates (70.8 %) as compared to community-acquired (26.9 %). the most frequently isolated pathogens were ... | 2010 | 20538892 |
| sepsis and cardiomyopathy as rare clinical manifestations of pheochromocytoma--two case report studies. | the clinical manifestation of pheochromocytomas is highly variable and can closely resemble numerous clinical conditions. here, we report on two cases of patients with pheochromocytoma, which manifested as sepsis or cardiomyopathy. the first patient initially presented with bacterial urosepsis due to klebsiella oxytoca. despite effective antibiotic therapy, the patient developed recurring fever accompanied by hypertension. the inconsistency between therapy-refractory hypertension and fever indic ... | 2010 | 20539976 |
| hypermutability in clinical isolates of klebsiella pneumoniae is uncommon and is unrelated to ciprofloxacin resistance. | we investigated hypermutability in klebsiella pneumoniae and its association with ciprofloxacin resistance and mutations in the quinolone resistance-determining region (qrdr). sixty-four strains of k. pneumoniae isolated in london, uk, between 1995 and 2002 with widely differing ciprofloxacin minimum inhibitory concentrations (mics) and known gyra and parc sequences were tested for mutation frequencies by selection with rifampicin. only three hypermutable (frequency >or=10(-6)) strains were iden ... | 2010 | 20541915 |
| in vitro antimicrobial, anthelmintic and cyclooxygenase-inhibitory activities and phytochemical analysis of leucosidea sericea. | leucosidea sericea is used as a vermifuge and in the treatment of ophthalmia by various tribes in southern african countries. | 2010 | 20542105 |
| comparative in vitro activity of cefditoren and other antimicrobials against enterobacteriaceae causing community-acquired uncomplicated urinary tract infections in women: a spanish nationwide multicenter study. | cefditoren is a third-generation orally administered cephalosporin with a broad spectrum of activity against gram-positive and gram-negative bacterial species. after an oral 400-mg single dose, the mean concentrations in urine are 186.5 mg/l at 2 to 4 h and 12.7 mg/l at 8 to 12 h, and it is a potential drug to be used in the treatment of urinary tract infection (uti). we performed a multicenter nationwide study in spain in order to determine the in vitro activity of cefditoren and other comparat ... | 2010 | 20542206 |
| activity of topical antimicrobial agents against multidrug-resistant bacteria recovered from burn patients. | topical antimicrobials are employed for prophylaxis and treatment of burn wound infections despite no established susceptibility breakpoints, which are becoming vital in an era of multidrug-resistant (mdr) bacteria. we compared two methods of determining topical antimicrobial susceptibilities. | 2010 | 20542641 |
| nodulation in black locust by the gammaproteobacteria pseudomonas sp. and the betaproteobacteria burkholderia sp. | nodulation abilities of bacteria in the subclasses gammaproteobacteria and betaproteobacteria on black locust (robinia pseudoacacia) were tested. pseudomonas sp., burkholderia sp., klebsiella sp., and paenibacillus sp. were isolated from surface-sterilized black locust nodules, but their nodulation ability is unknown. the aims of this study were to determine if these bacteria are symbiotic. the species and genera of the strains were determined by rflp analysis and dna sequencing of 16s rrna gene ... | 2010 | 20542651 |
| infections after primary and revision total hip replacement caused by enterobacteria producing extended spectrum beta-lactamases (esbl): a case series. | implant infection remains a feared complication after total hip replacement. a higher rate of infection is observed after revision surgery. an additional threat for such patients arises from the fact that bacteria resistant to a multitude of antibiotics are encountered with increasing frequency in the hospital setting. among them enterobacteria producing extended spectrum beta-lactamases (esbl) are the second most frequent group of multiresistant isolates. esbls are enzymes which hydrolyse third ... | 2010 | 20544658 |
| [antimicrobial activity of meropenem against main bacterial species isolated from patient blood in 2008]. | we examined the antimicrobial activities of meropenem and other antibiotics against main bacteria isolated from patient blood in keio university hospital between january and november in 2008. a total of 187 isolates, including 43 escherichia coli, 23 klebsiella pneumoniae, 9 enterobacter cloacae, 22 pseudomonas aeruginosa, 16 methicillin-susceptible staphylococcus aureus (mssa), 24 methicillin-resistant staphylococcus aureus (mrsa), 50 staphylococcus epidermidis were tested. meropenem showed the ... | 2009 | 20545084 |
| pulmonary amyloidosis in sjogren's syndrome: a case report and systematic review of the literature. | amyloidosis is a heterogeneous group of disorders characterized by misfolding of extracellular proteins. the two most common forms are light-chain (al) and reactive (aa) amyloidosis. pulmonary amyloidosis secondary to sjogren's syndrome (ss) is rare, and there is a paucity of data on its clinical and radiological features. we describe the case of a 41-year-old woman with diffuse septal pulmonary al (lambda) amyloidosis related to ss, in the absence of systemic amyloidosis. a systematic search fo ... | 2010 | 20546191 |
| dramatic increase of third-generation cephalosporin-resistant e. coli in german intensive care units: secular trends in antibiotic drug use and bacterial resistance, 2001 to 2008. | the objective of the present study was to analyse secular trends in antibiotic consumption and resistance data from a network of 53 intensive care units (icus). | 2010 | 20546564 |
| pharmacokinetic-pharmacodynamic profiling of four antimicrobials against gram-negative bacteria collected from shenyang, china. | to examine common antimicrobial regimens used in eradicating certain nosocomial gram-negative pathogens and determine which ones are likely to be the most suitable as empirical choices in shenyang, china. | 2010 | 20546625 |
| hypermucoviscosity associated with klebsiella pneumoniae-mediated invasive syndrome: a prospective cross-sectional study in taiwan. | to investigate the association between klebsiella pneumoniae-mediated invasive syndrome and underlying diseases in patients and/or k. pneumoniae characteristics, including the rmpa, rmpa2, and maga genes, capsular polysaccharide (cps) k(1) or k(2) serotypes, hypermucoviscosity (hv) phenotype, and extended-spectrum beta-lactamase (esbl) production. | 2010 | 20547084 |
| outbreak caused by a multi-resistant klebsiella pneumoniae strain of new sequence type st341 carrying new genetic environments of aac(6')-ib-cr and qnrs1 genes in a neonatal intensive care unit in spain. | an outbreak due to a klebsiella pneumoniae clone occurred in a neonatal intensive care unit of a spanish hospital in which three newborns were infected (all with gestational age ≤29 weeks; two of them died) and seven were colonized (gestational age >32 weeks; none died). one k. pneumoniae strain per patient was further characterized. the 10 strains showed an indistinguishable pulsed-field-gel-electrophoresis pattern, were typed in the phylogenetic group kpi and were ascribed into a new sequence ... | 2010 | 20547103 |
| complete nucleotide sequence of klebsiella pneumoniae multidrug resistance plasmid pkp048, carrying blakpc-2, bladha-1, qnrb4, and arma. | the klebsiella pneumoniae multidrug resistance plasmid pkp048 was completely sequenced. this plasmid carries several important resistance determinants, such as bla(kpc-2), bla(dha-1), qnrb4, and arma, which confer resistance to carbapenems, cephalosporins, fluoroquinolones, and aminoglycosides, respectively. analysis of the finished 151,188-bp sequence data revealed 163 putative genes, 108 of which were assigned functions such as replication, stable inheritance, antibiotic resistance, a mobile e ... | 2010 | 20547789 |
| evaluation of a dna microarray, the check-points esbl/kpc array, for rapid detection of tem, shv, and ctx-m extended-spectrum beta-lactamases and kpc carbapenemases. | extended-spectrum beta-lactamases (esbls) and klebsiella pneumoniae carbapenemases (kpc carbepenemases) have rapidly emerged worldwide and require rapid identification. the check-points esbl/kpc array, a new commercial system based on genetic profiling for the direct identification of esbl producers (shv, tem, and ctx-m) and of kpc producers, was evaluated. well-characterized gram-negative rods (enterobacteriaceae, pseudomonas aeruginosa, acinetobacter baumannii) expressing various ss-lactamases ... | 2010 | 20547813 |
| effect of cumin (cuminum cyminum) seed essential oil on biofilm formation and plasmid integrity of klebsiella pneumoniae. | seeds of the cumin plant (cuminum cyminum l.) have been used since many years in iranian traditional medicine. we assessed the effect of cumin seed essential oil on the biofilm-forming ability of klebsiella pneumoniae strains and on the integrity of a native resistance plasmid dna from k. pneumoniae isolates, treated with essential oil. antibacterial coaction between the essential oil and selected antibiotic disks were determined for inhibiting k. pneumoniae. the essential oil of the cumin seeds ... | 2010 | 20548937 |
| nosocomial infections and fever of unknown origin in pediatric hematology/oncology unit: a retrospective annual study. | pediatric hematology/oncology patients are faced with an increased risk of nosocomial infections (nis) that vary in different populations and different institutions with considerable morbidity and mortality. this study was undertaken to assess the frequency and patterns of nis in 1564 pediatric patients and to determine the prevalence of causative organisms and their antimicrobial sensitivity. | 2011 | 20549409 |
| the molecular characteristics of cefepime-susceptible escherichia coli and klebsiella spp. isolates with a positive β-lactamase screening test result but negative confirmation. | a negative extended-spectrum β-lactamase (esbl) phenotypic confirmation test result obtained after a positive esbl screening test result but which was cefepime-susceptible (ncpscs) using the clinical and laboratory standards institute (clsi) methods has been observed among isolates of escherichia coli and klebsiella spp. in the antimicrobial surveillance program in shanghai, china. among isolates collected from huashan hospital in 2005, ncpscs strains were observed in 2.5% of 433 e. coli isolate ... | 2010 | 20549530 |
| [detection of bla(ctx-m) beta-lactamase genes in extended-spectrum beta-lactamase producing gram-negative bacteria]. | widespread production of ctx-m type extended-spectrum beta-lactamases (esbl) in enterobacteriaceae strains which are resistant to extended-spectrum cephalosporins is the most remarkable example for rapid and global spread of plasmid mediated antimicrobial resistance in bacteria. consecutive 200 esbl producing enterobacteriaceae strains out of 1640 isolates that were obtained from clinical samples (167 urine, 11 wound, 7 bronchoalveolar lavage, 3 peritoneal fluid, 2 cerebrospinal fluid, 2 biopsy, ... | 2010 | 20549952 |
| screening and optimization of indole-3-acetic acid production and phosphate solubilization from rhizobacteria aimed at improving plant growth. | a total of 216 bacterial strains were isolated from rice rhizospheric soils in northern thailand. the bacterial strains were initially tested for solubilization of inorganic phosphate, indole acetic acid (iaa) production, selected strains were then tested for optimized conditions for iaa production and whether these caused stimulatory effects on bean and maize seedling growth. it was found that all strains had solubilized inorganic phosphate (p), but only 18.05% produced iaa. the best iaa produc ... | 2011 | 20552360 |
| [epidemiology of patients harboring extended-spectrum beta-lactamase-producing enterobacteriaceae (esble), on admission]. | the incidence of extended-spectrum beta-lactamase-producing enterobacteria (esble) has regularly increased over the last few years. however, little is known about epidemiology of esble carriers in france. the objective of this study was to determine the esble carriers or infected patients profile, identified within 48 hours following hospital admission. | 2010 | 20554140 |
| [characterization of the variable region within class 1 integrons in klebsiella pneumoniae nosocomials strains]. | integrons are responsible for the capture and dissemination of resistance genes in gram-negative bacteria. | 2010 | 20556335 |
| the cyclotide cycloviolacin o2 from viola odorata has potent bactericidal activity against gram-negative bacteria. | to determine the antibacterial activity of small cyclic plant proteins, i.e. cyclotides, and the importance of the surface exposed charged residues for activity. | 2010 | 20558471 |
| x-ray diagnosis of fatal fournier's gangrene caused by klebsiella pneumoniae. | | 2011 | 20558485 |
| [the role of microflora in etiology of chronic tonsillitis]. | analysis of the results of a bacteriological study involving 218 patients with various forms of chronic tonsillitis (ct) has demonstrated that they were significantly different in terms of the seeding rate of beta-hemolytic group a streptococci (bhas). specifically, these microorganisms were detected in patients with paratonsillar abscess 2.5 times as frequently as in those with uncomplicated forms of chronic tonsilitis. in other words, the former group is at risk of developing such concomitant ... | 2010 | 20559241 |
| an unusual case of recurrent endogenous klebsiella endophthalmitis. | | 2010 | 20559330 |
| substitution of the arginine/leucine residues in apidaecin ib with peptoid residues: effect on antimicrobial activity, cellular uptake, and proteolytic degradation. | several aspects of the mechanism of action of pro-rich antimicrobial peptides, together with their low toxicity in mammalian cells, make them good candidates for the development of new antibiotic agents. we investigated the effect induced in the insect antimicrobial peptide apidaecin ib by the replacement of a single arginine/leucine residue with a n-substituted glycine. the resulting peptoid-peptide hybrids are more resistant to proteolysis and devoid of any significant cytotoxic activity, but ... | 2009 | 20560644 |
| clinical and microbiological characteristics of bloodstream infections in a tertiary hospital in maceió, alagoas, brazil. | we observed the clinical and microbiological characteristics of several stages of bloodstream infections (bsi), as well as the mortality attributed to it in a tertiary hospital in the northeast of brazil (in the city of maceió, alagoas). a prospective cohort of 143 patients who had at least one positive blood culture was enrolled in the study. their clinical evolution was followed up for 30 days from october 2005 to december 2006. the relation among the qualitative variables was verified through ... | 2010 | 20563445 |
| [dissemination of the kpc carbapenemase producing klebsiella pneumoniae in a hospital in warsaw, poland]. | within the last decade, human infections caused by enterobacteria which produce the klebsiella pneumoniae carbapenemase (kpc) became a serious therapeutic and epidemiological problem worldwide. the kpc producing strains of k. pneumoniae broadly disseminated in the usa then spread to europe. recently, the kpc-2 was found in poland. in the presented study we tested 11 ertapenem resistant isolates of k. pneumoniae. the isolates were obtained from 10 patients of a regular hospital (rh) and from one ... | 2010 | 20564966 |
| [application of enzyme linked immunosorbent assay (elisa) for diagnosis of antibodies to lipopolysaccharide of klebsiella rhinoscleromatis in patients with rhinoscleroma]. | the elisa were performed on polystyrene microtiter plates (nunc, maxisorp) coated with lps (2a antigen) at the final concentration of 10 microg/ml. the antigen was extracted from klebsiella rhinoscleromatis rh32 by the trichloroacetic acid and separated by ethanol (boivin method). the antibodies against the lps were detected by elisa in serum samples collected from 65 patients suspected in clinical investigation for rhinoscleroma in poland from 1970 to 2009. additionally, the specificity of the ... | 2010 | 20564967 |
| biochemical and structural characterization of a ureidoglycine aminotransferase in the klebsiella pneumoniae uric acid catabolic pathway. | many plants, fungi, and bacteria catabolize allantoin as a mechanism for nitrogen assimilation. recent reports have shown that in plants and some bacteria the product of hydrolysis of allantoin by allantoinase is the unstable intermediate ureidoglycine. while this molecule can spontaneously decay, genetic analysis of some bacterial genomes indicates that an aminotransferase may be present in the pathway. here we present evidence that klebsiella pneumoniae hpxj is an aminotransferase that prefere ... | 2010 | 20565126 |
| infectious complications in kidney transplant: a lebanese perspective. | infections remain a frequent, potentially life-threatening complication of kidney transplant. | 2010 | 20565370 |
| prevalence of asymptomatic bacteriuria in type 2 diabetic subjects with and without microalbuminuria. | abstract: | 2010 | 20565718 |
| differences in the bal proteome after klebsiella pneumoniae infection in wild type and sp-a-/- mice. | abstract: | 2010 | 20565803 |
| antimicrobial susceptibility and beta-lactamase production of selected gram-negative bacilli from two croatian hospitals: mystic study results. | the meropenem yearly susceptibility test information collection (mystic) programme is a global, longitudinal resistance surveillance network that monitors the activity of meropenem and compares its activity with other broadspectrum antimicrobial agents. we now report the antimicrobial efficacy of meropenem compared to other broad-spectrum agents within the selective gram-negative pathogen groups from two croatian hospitals investigated between 2002-2007. a total of 1510 gram-negative pathogens w ... | 2010 | 20566417 |
| antibiotic susceptibility of respiratory pathogens recently isolated in italy: focus on cefditoren. | the aim of this study was to evaluate the in vitro antibiotic susceptibility of respiratory pathogens recently isolated in italy to commonly used antibiotics including cefditoren. six clinical microbiological laboratories collected, between january and september 2009, a total of 2,510 respiratory pathogens from subjects with community-acquired respiratory tract infections (carti). ceftditoren, out of all the beta-lactams studied, had the lowest mic(90 )against 965 strains of streptococcus pneumo ... | 2010 | 20566418 |
| identification of shv-type and ctx-m-12 extended-spectrum beta-lactamases (esbls) in multiresistant enterobacteriaceae from colombian caribbean hospitals. | the production of extended-spectrum beta-lactamases (esbls) in enterobacteriaceae is the most prevalent resistance mechanism to third-generation cephalosporins. the aim of this study was to identify the esbls produced in escherichia coli and klebsiella pneumoniae clinical isolates from two hospitals of the colombian caribbean region. a total of 30 clinical isolates of k. pneumoniae (21) and e. coli (9) esbl-producers were collected in two hospitals from january, 2001 to june, 2003. isoelectric p ... | 2010 | 20566419 |
| emergence of kpc-2 carbapenemase-producing klebsiella pneumoniae strains and spread of an isolate of sequence type 258 in the neuro-rehabilitation unit of an italian hospital. | | 2010 | 20566429 |
| antimicrobial susceptibility testing of newer quinolones against gram positive and gram negative clinical isolates. | antibiotic resistance development is an ongoing process associated with irrational antibiotic use. who recommends regular surveillance programs for monitoring of antibiotic resistance. the present study is a step in this direction. a total of 124 clinical isolates of escherichia coli, staphylococcus aureus, klebsiella pneumoniae and pseudomonas aeruginosa were collected from different hospitals in karachi. in vitro antimicrobial susceptibility studies were carried out by agar dilution method usi ... | 2010 | 20566434 |
| chromosomally encoded blacmy-2 located on a novel sxt/r391-related integrating conjugative element in a proteus mirabilis clinical isolate. | integrating conjugative elements (ices) are mobile genetic elements that can transfer from the chromosome of a host to the chromosome of a new host through the process of excision, conjugation, and integration. although sxt/r391-related ices, originally demonstrated in vibrio cholerae o139 isolates, have become prevalent among v. cholerae isolates in asia, the prevalence of the ices among gram-negative bacteria other than vibrio spp. remains unknown. in addition, sxt/r391-related ices carrying g ... | 2010 | 20566768 |
| antimicrobial susceptibility of metallo-beta-lactamase positive and negative klebsiella pneumoniae strains isolated from intensive care unit patients. | carbapenem resistance in gram-negative bacteria is a worldwide increasing and one of the most disturbing problems, given these antibiotics are drugs of choice in the treatment of infections caused by extended-spectrum-beta-lactamase producing strains. in this study the antibiotic susceptibility of metallo-beta-lactamase-positive and negative klebsiella pneumoniae strains isolated from intensive care unit (icu) patients was evaluated. the presence of genes encoding mbls was determined with a comm ... | 2010 | 20568533 |
| molybdenum carbide as anodic catalyst for microbial fuel cell based on klebsiella pneumoniae. | a pure beta-molybdenum carbide (m(o2)c) with a brunauer-emmett-teller (bet) special surface area of 77.5 m2/g, prepared by solution derived precursor, was used as anodic catalyst of microbial fuel cell (mfc) based on klebsiella pneumoniae (k. pneumoniae). the electrochemical activity of the prepared m(o2)c and the performance of the mfc were investigated by cyclic voltammetry (cv), electrochemical impedance spectroscopy (eis) and polarization curve measurement. the results show that the prepared ... | 2010 | 20570127 |
| air in the urinary system. | | 2011 | 20571353 |
| [extended spectrum beta lactamase forming bacteria--an increasing and serious problem in ambulatory medicine]. | | 2010 | 20571997 |
| role of type 1 and type 3 fimbriae in klebsiella pneumoniae biofilm formation. | klebsiella pneumoniae is an important gram-negative opportunistic pathogen causing primarily urinary tract infections, respiratory infections, and bacteraemia. the ability of bacteria to form biofilms on medical devices, e.g. catheters, has a major role in development of many nosocomial infections. most clinical k. pneumoniae isolates express two types of fimbrial adhesins, type 1 fimbriae and type 3 fimbriae. in this study, we characterized the role of type 1 and type 3 fimbriae in k. pneumonia ... | 2010 | 20573190 |
| first report of septic arthritis caused by klebsiella oxytoca. | klebsiella oxytoca is known to be a pathogen in immunodeficient adults and children. here we report the first case of a k. oxytoca infection associated with spontaneous arthritis of the knee in a child with no history of immunosuppressive therapy or previous bacterial infections. despite an initial antibiotic treatment failure, a second treatment led to a cure of the infection with no joint sequelae. | 2010 | 20573877 |
| biodegradation of chlorimuron-ethyl by the bacterium klebsiella jilinsis 2n3. | enrichment culturing of sludge taken from an industrial wastewater treatment pond led to the identification of a bacterium (klebsiella jilinsis h. zhang) that degrades chlorimuron-ethyl with high efficiency. klebsiella jilinsis strain 2n3 grows with chlorimuron-ethyl as the sole nitrogen source at the optimal temperature range of 30-35 degrees c and ph values between 6.0-7.0. in liquid medium, the degradation activity was further induced by chlorimuron-ethyl. degradation rates followed the pesti ... | 2010 | 20574870 |
| antibacterial properties of tualang honey and its effect in burn wound management: a comparative study. | the use of honey as a natural product of apis spp. for burn treatment has been widely applied for centuries. tualang honey has been reported to have antibacterial properties against various microorganisms, including those from burn-related diagnoses, and is cheaper and easier to be absorbed by aquacel dressing. the aim of this study is to evaluate the potential antibacterial properties of tualang honey dressing and to determine its effectiveness as a partial thickness burn wound dressing. | 2010 | 20576085 |
| molecular analysis of type 3 fimbrial genes from escherichia coli, klebsiella and citrobacter species. | catheter-associated urinary tract infection (cauti) is the most common nosocomial infection in the united states and is caused by a range of uropathogens. biofilm formation by uropathogens that cause cauti is often mediated by cell surface structures such as fimbriae. in this study, we characterised the genes encoding type 3 fimbriae from cauti strains of escherichia coli, klebsiella pneumoniae, klebsiella oxytoca, citrobacter koseri and citrobacter freundii. | 2010 | 20576143 |
| bacterial lipopolysaccharides variably modulate in vitro biofilm formation of candida species. | the objective of this study was to evaluate the effect of the bacterial endotoxin lps on candida biofilm formation in vitro. the effect of the lps of pseudomonas aeruginosa, klebsiella pneumoniae, serratia marcescens and salmonella typhimurium on six different species of candida, comprising candida albicans atcc 90028, candida glabrata atcc 90030, candida krusei atcc 6258, candida tropicalis atcc 13803, candida parapsilosis atcc 22019 and candida dubliniensis mya 646, was studied using a standar ... | 2010 | 20576747 |
| clonal spread of ctx-m-15-producing klebsiella pneumoniae in a croatian hospital. | this study was conducted to detect and analyse the presence of extended-spectrum beta-lactamase (esbl)-producing klebsiella pneumoniae associated with a nosocomial outbreak at a croatian hospital. during 2007, 162 k. pneumoniae isolates with reduced susceptibility to third-generation cephalosporins were collected from various hospital units and patient specimens. most of the strains were isolated from urine (61 %), followed by blood cultures (13 %), wound swabs (13 %), tracheal aspirates (5 %), ... | 2010 | 20576749 |