| neurodevelopmental disorders: risks of zika virus during the first trimester of pregnancy. | | 2016 | 27150532 |
| zika virus and pregnancy. | | 2016 | 27150456 |
| asymptomatic pregnant women returning to the united states from countries experiencing a zika virus outbreak should be tested for zika virus : for: importance of identification in all pregnant women. | | 2016 | 27150136 |
| asymptomatic pregnant women returning to the united states from countries experiencing a zika virus outbreak should be tested for zika virus: against: not so fast. | | 2016 | 27149896 |
| update: ongoing zika virus transmission - puerto rico, november 1, 2015-april 14, 2016. | zika virus is a flavivirus transmitted primarily by aedes species mosquitoes, and symptoms of infection can include rash, fever, arthralgia, and conjunctivitis (1).* zika virus infection during pregnancy is a cause of microcephaly and other severe brain defects (2). infection has also been associated with guillain-barré syndrome (3). in december 2015, puerto rico became the first u.s. jurisdiction to report local transmission of zika virus, with the index patient reporting symptom onset on novem ... | 2016 | 27149205 |
| [clinical analysis of two cases of imported children zika virus infection in china]. | to analyze the clinical characteristics, outcome and diagnosis of two cases of imported children zika virus infection in china. | 2016 | 27143081 |
| zika virus study in the bmj was different from the one reported in the new england journal of medicine. | | 2016 | 27142055 |
| epidemiology: which regions are vulnerable to zika virus? | | 2016 | 27140691 |
| zika virus disease in travelers returning to the united states, 2010-2014. | zika virus is an emerging mosquito-borne flavivirus that typically causes a mild febrile illness with rash, arthralgia, or conjunctivitis. zika virus has recently caused large outbreaks of disease in southeast asia, pacific ocean islands, and the americas. we identified all positive zika virus test results performed at u.s. centers for disease control and prevention from 2010 to 2014. for persons with test results indicating a recent infection with zika virus, we collected information on demogra ... | 2016 | 27139440 |
| neonatal neuroradiological aspects in zika virus infection. | | 2016 | 27138556 |
| [zika virus, an emerging threat]. | zika virus, discovered in 1947, is particularly publicized because of its involvement in a major epidemic that began in 2015 and which epicenter is located in latin america, mainly in brazil. in the majority of cases (70-80 %) the infection is asymptomatic, however in some patients, moderate fever, skin rash, conjunctivitis and myalgia may occur. more alarming, neurological complications are reported, in particular cases of microcephaly probably resulting from the infection of women in the first ... | 2016 | 27137695 |
| the emergence of zika virus: a narrative review. | zika virus (zikv) is yet another arbovirus that is rapidly emerging on a global scale, on the heels of a chikungunya epidemic in the americas that began in 2013. a zikv epidemic that began in brazil in 2015 has now spread rapidly to more than 30 countries in the americas and the caribbean, infecting more than 2 million inhabitants. this epidemic currently continues unabated. the explosive nature of recent outbreaks and concerning links to guillain-barré syndrome and microcephaly are incompletely ... | 2016 | 27135717 |
| dtb select: 5 | may 2016. | hyperkalaemia with spironolactone ● testosterone treatment in older men and sexual function ● otc artificial tear drops for dry eye ● decline in age-specific incidence of dementia ● diabetes and blood pressure targets ● zika virus and travel advice for pregnant women ● minimising the risk of dka with sglt2 inhibitors ● nsaids for chronic low back pain ● review of online point-of-care information. | 2016 | 27130673 |
| phylogenetic analysis revealed the central roles of two african countries in the evolution and worldwide spread of zika virus. | recent outbreaks of zika virus (zikv) infections in oceania's islands and the americas were characterized by high numbers of cases and the spread of the virus to new areas. to better understand the origin of zikv, its epidemic history was reviewed. although the available records and information are limited, two major genetic lineages of zikv were identified in previous studies. however, in this study, three lineages were identified based on a phylogenetic analysis of all virus sequences from gen ... | 2016 | 27129451 |
| zika virus and zika fever. | an emerging mosquito-borne arbovirus named zika virus (zikv), of the family flaviviridae and genus flavivirus, is becoming a global health threat. zikv infection was long neglected due to its sporadic nature and mild symptoms. however, recently, with its rapid spread from asia to the americas, affecting more than 30 countries, accumulating evidences have demonstrated a close association between infant microcephaly and zika infection in pregnant women. here, we reviewed the virological, epidemiol ... | 2016 | 27129450 |
| confirmed zika virus infection in a belgian traveler returning from guatemala, and the diagnostic challenges of imported cases into europe. | we report the first laboratory-confirmed zika virus (zikv) infection in a belgian traveler after a three week holiday in guatemala, december 2015. this case along with other imported cases into europe emphases once again the need for accurate diagnostic tools for this rapidly emerging virus. the challenge is to diagnose patients in the acute phase, which appears short, as serological testing is complicated by cross-reactivity, vaccination status and scarce availability of specific zikv tests. | 2016 | 27128355 |
| zika virus detection in cerebrospinal fluid from two patients with encephalopathy, martinique, february 2016. | we report two cases of encephalopathy (one with seizures, one with electroencephalogram changes) in patients with zika virus infection. the cases occurred on martinique in february 2016, during the zika virus outbreak. awareness of the various neurological complications of zika virus infection is needed for patients living in areas affected by zika virus infections or for travellers to these areas. | 2016 | 27123558 |
| [suspected zika virus infection: who should be tested?]. | | 2016 | 27119856 |
| zika virus-associated guillain-barré syndrome: a warning for critical care physicians. | | 2016 | 27118575 |
| brain-region-specific organoids using mini-bioreactors for modeling zikv exposure. | cerebral organoids, three-dimensional cultures that model organogenesis, provide a new platform to investigate human brain development. high cost, variability, and tissue heterogeneity limit their broad applications. here, we developed a miniaturized spinning bioreactor (spinω) to generate forebrain-specific organoids from human ipscs. these organoids recapitulate key features of human cortical development, including progenitor zone organization, neurogenesis, gene expression, and, notably, a di ... | 2016 | 27118425 |
| guillain-barré syndrome associated with zika virus infection. | | 2016 | 27115821 |
| exposure of a dengue vector to tea and its waste: survival, developmental consequences, and significance for pest management. | dengue mosquitoes are evolving into a broader global public health menace, with relentless outbreaks and the rise in number of zika virus disease cases as reminders of the continued hazard associated with aedes vectors. the use of chemical insecticides-the principal strategy against mosquito vectors-has been greatly impeded due to the development of insecticide resistance and the shrinking spectrum of effective agents. therefore, there is a pressing need for new chemistries for vector control. t ... | 2016 | 27115536 |
| top 10 facts you need to know about zika virus. | | 2016 | 27111981 |
| zika virus could infect up to four million, who predicts. | | 2016 | 27111968 |
| the paradigm of the paradox: women, pregnant women, and the unequal burdens of the zika virus pandemic. | | 2016 | 27111356 |
| zika virus and microcephaly: challenges for a long-term agenda. | since its introduction in brazil in 2015, zika virus (zikv) has begun to spread worldwide. one of the major infection outcomes is related to congenital malformations, but little is known about the pathogenicity of zikv. here we discuss concerns about the ongoing zikv epidemic in the context of academic research, politics, and society. | 2016 | 27105931 |
| isolation and characterization of zika virus imported to china using c6/36 mosquito cells. | | 2016 | 27105638 |
| assessing the potential risk of zika virus epidemics in temperate areas with established aedes albopictus populations. | based on 2015 abundance of aedes albopictus in nine northern italian municipalities with temperate continental/oceanic climate, we estimated the basic reproductive number r0 for zika virus (zikv) to be systematically below the epidemic threshold in most scenarios. results were sensitive to the value of the probability of mosquito infection after biting a viraemic host. therefore, further studies are required to improve models and predictions, namely evaluating vector competence and potential non ... | 2016 | 27104366 |
| zika virus and hyperglycaemia in pregnancy. | | 2016 | 27103128 |
| positive igm for zika virus in the cerebrospinal fluid of 30 neonates with microcephaly in brazil. | | 2016 | 27103126 |
| rumor has it; the truth behind zika virus. | | 2017 | 27102926 |
| zika virus infection during pregnancy and microcephaly occurrence: a review of literature and brazilian data. | in november of 2015, the ministry of health of brazil published an announcement confirming the relationship between zika virus and the microcephaly outbreak in the northeast, suggesting that infected pregnant women might have transmitted the virus to their fetuses. the objectives of this study were to conduct a literature review about zika virus infection and microcephaly, evaluate national and international epidemiological data, as well as the current recommendations for the health teams. zika ... | 2017 | 27102780 |
| patterns in zika virus testing and infection, by report of symptoms and pregnancy status - united states, january 3-march 5, 2016. | cdc recommends zika virus testing for potentially exposed persons with signs or symptoms consistent with zika virus disease, and recommends that health care providers offer testing to asymptomatic pregnant women within 12 weeks of exposure. during january 3-march 5, 2016, zika virus testing was performed for 4,534 persons who traveled to or moved from areas with active zika virus transmission; 3,335 (73.6%) were pregnant women. among persons who received testing, 1,541 (34.0%) reported at least ... | 2016 | 27101541 |
| knowledge regarding zika virus infection among dental practitioners of tricity area (chandigarh, panchkula and mohali), india. | zika virus (zikv), a vector-borne virus affecting a large number of people, has today become a major public health concern in the developed and developing countries worldwide. | 2016 | 27098947 |
| zika virus: what nurses need to know. | | 2016 | 27096910 |
| zika virus and maxillofacial surgery. | | 2016 | 27094497 |
| public health authorities race to contain fast-moving zika outbreak. | with the zika virus disease spreading rapidly through latin america, public health authorities in the united states are racing to contain the outbreak. by the end of february, the cdc had confirmed 147 zika cases in u.s. residents who had traveled to zika-endemic areas. while symptoms of zika tend to be mild, the virus has been linked to serious birth defects, so public health efforts are focused primarily at mitigating the risk zika poses to pregnant women. by mid-february, nine pregnant women ... | 2016 | 27093766 |
| zika virus, emergencies, uncertainty and vulnerable populations. | | 2016 | 27092361 |
| emergency contraception in a public health emergency: exploring pharmacy availability in brazil. | dedicated progestin-only emergency contraceptive pills (ecps) have been available with a prescription in brazil since 1999. however, utilization of emergency contraception has been limited. we conducted a mystery client study at retail pharmacies in three regions to assess current availability. | 2016 | 27091724 |
| from mosquitos to humans: genetic evolution of zika virus. | initially isolated in 1947, zika virus (zikv) has recently emerged as a significant public health concern. sequence analysis of all 41 known zikv rna open reading frames to date indicates that zikv has undergone significant changes in both protein and nucleotide sequences during the past half century. | 2016 | 27091703 |
| zika virus: a new human teratogen? implications for women of reproductive age. | in 2015 an unprecedented increase of reports of newborns with microcephaly in brazil made news headlines around the world. a possible etiological association with prenatal maternal infection by zika virus (zikv) was suggested based on temporal and geographic distribution of zikv infection and the subsequent increase in the reports of microcephaly cases. here we discuss zikv as a new human teratogen, with comments on potential treatment options. | 2016 | 27090438 |
| once and future epidemics: zika virus emerging. | | 2016 | 27089202 |
| mass gatherings and the spread of respiratory infections. lessons from the hajj. | the mass gathering of people is a potential source for developing, propagating, and disseminating infectious diseases on a global scale. of the illnesses associated with mass gatherings, respiratory tract infections are the most common, the most easily transmitted, and the most likely to be spread widely beyond the site of the meeting by attendees returning home. many factors contribute to the spread of these infections during mass gatherings, including crowding, the health of the attendees, and ... | 2016 | 27088298 |
| [zika virus as a new threat to the health and life]. | the newly emerging pathogens are increasingly becoming a threat to health and life, as the cause of epidemic infections. in the last three years there were outbreaks caused by zika virus, which was transmitted by mosquitoes mainly from the region of south america. however, reports who and cdc indicate that infection has now reached to most countries of the world, including european countries. the clinical picture of what is observed during the infection is not very distinctive, because apart fro ... | 2016 | 27088194 |
| [several issues on the epidemiology of zika virus disease]. | zika virus belongs to aedes mosquito-borne flavivirus. in response to the current cluster of congenital malformations (microcephaly) and other neurological complications (guillain-barré syndrome) that could be linked to zika virus infection, who declares that zika virus is of global public health importance. data sources were from peer review articles and who documents. the sources of zika virus infection would include patients, people with asymptomatic infections and primates. the infectious pe ... | 2016 | 27087204 |
| neuroimaging findings of babies with microcephaly and presumed congenital zika virus infection. | | 2016 | 27083981 |
| us agency says zika virus causes microcephaly. | | 2016 | 27083694 |
| zika virus advice for mountaineers: a uiaa medcom consensus advice sheet. | hillebrandt, david, paul richards, andy clark, and dominique jean. zika virus advice for mountaineers: a uiaa medcom consensus advice sheet. high alt med biol. 17:70-71, 2016.-with the current media coverage of the spread of zika virus from africa and asia to central and south america and its possible relationship with fetal abnormalities, uiaa medcom has produced an advice sheet for mountaineers visiting risk areas. | 2016 | 27081746 |
| [zika virus infection during pregnancy]. | a zika virus epidemic is currently ongoing in the americas. this virus is linked to congenital infections with potential severe neurodevelopmental dysfunction. however, incidence of fetal infection and whether this virus is responsible of other fetal complications are still unknown. national and international public health authorities recommend caution and several prevention measures. declaration of zika virus infection is now mandatory in france. given the available knowledge on zika virus, we ... | 2016 | 27079865 |
| survey of blood collection centers and implementation of guidance for prevention of transfusion-transmitted zika virus infection--puerto rico, 2016. | since november 2015, puerto rico has reported active mosquito-borne transmission of zika virus. because of the potential for zika virus to be transmitted through transfusion of blood components, and because a high percentage of persons infected with zika virus are asymptomatic, the food and drug administration (fda) recommended that blood collections cease in areas of the united states affected by active vector-borne transmission of zika virus until laboratory screening of blood donations or pat ... | 2016 | 27078190 |
| male-to-male sexual transmission of zika virus--texas, january 2016. | zika virus infection has been linked to increased risk for guillain-barré syndrome and adverse fetal outcomes, including congenital microcephaly. in january 2016, after notification from a local health care provider, an investigation by dallas county health and human services (dchhs) identified a case of sexual transmission of zika virus between a man with recent travel to an area of active zika virus transmission (patient a) and his nontraveling male partner (patient b). at this time, there had ... | 2016 | 27078057 |
| search and one will find: zika virus everywhere. | | 2016 | 27076507 |
| one-step synthesis of polydispersed silver nanocrystals using malva sylvestris: an eco-friendly mosquito larvicide with negligible impact on non-target aquatic organisms. | the synthesis of eco-friendly nanoparticles is evergreen branch of nanoscience with a growing number of biomedical implications. in this study, we investigated the synthesis of polydisperse and stable silver nanoparticles (agnp) using a cheap leaf extract of malva sylvestris (malvaceae). bio-reduced agnp were characterized by uv-visible spectrophotometry, fourier transform infrared spectroscopy (ftir), x-ray diffraction analysis (xrd), atomic force microscopy (afm), scanning electron microscopy ... | 2016 | 27075309 |
| zika virus and birth defects--reviewing the evidence for causality. | | 2016 | 27074377 |
| evidence of sexual transmission of zika virus. | | 2016 | 27074370 |
| is the united states prepared for a major zika virus outbreak? | | 2016 | 27074330 |
| jama patient page. zika virus disease. | | 2016 | 27074312 |
| zika virus as new emerging global health threat for pregnancy and child birth. | | 2017 | 27072040 |
| zika virus complete genome from salvador, bahia, brazil. | | 2016 | 27071531 |
| zika virus associated deaths in colombia. | | 2016 | 27068488 |
| magnetic resonance imaging findings in guillain-barré syndrome caused by zika virus infection. | | 2016 | 27067205 |
| zika virus: what do we know? | | 2016 | 27067096 |
| zika virus and neural developmental defects: building a case for a cause. | | 2016 | 27066795 |
| a mouse model of zika virus pathogenesis. | the ongoing zika virus (zikv) epidemic and unexpected clinical outcomes, including guillain-barré syndrome and birth defects, has brought an urgent need for animal models. we evaluated infection and pathogenesis with contemporary and historical zikv strains in immunocompetent mice and mice lacking components of the antiviral response. four- to six-week-old irf3(-/-)irf5(-/-)irf7(-/-) triple knockout mice, which produce little interferon α/β, and mice lacking the interferon receptor (ifnar1(-/-)) ... | 2016 | 27066744 |
| type iii interferons produced by human placental trophoblasts confer protection against zika virus infection. | during mammalian pregnancy, the placenta acts as a barrier between the maternal and fetal compartments. the recently observed association between zika virus (zikv) infection during human pregnancy and fetal microcephaly and other anomalies suggests that zikv may bypass the placenta to reach the fetus. this led us to investigate zikv infection of primary human trophoblasts (phts), which are the barrier cells of the placenta. we discovered that pht cells from full-term placentas are refractory to ... | 2016 | 27066743 |
| zika virus impairs growth in human neurospheres and brain organoids. | since the emergence of zika virus (zikv), reports of microcephaly have increased considerably in brazil; however, causality between the viral epidemic and malformations in fetal brains needs further confirmation. we examined the effects of zikv infection in human neural stem cells growing as neurospheres and brain organoids. using immunocytochemistry and electron microscopy, we showed that zikv targets human brain cells, reducing their viability and growth as neurospheres and brain organoids. th ... | 2016 | 27064148 |
| congenital cerebral malformations and dysfunction in fetuses and newborns following the 2013 to 2014 zika virus epidemic in french polynesia. | we detected an unusual increase in congenital cerebral malformations and dysfunction in fetuses and newborns in french polynesia, following an epidemic of zika virus (zikv), from october 2013 to march 2014. a retrospective review identified 19 cases, including eight with major brain lesions and severe microcephaly, six with severe cerebral lesions without microcephaly and five with brainstem dysfunction without visible malformations. imaging revealed profound neurological lesions (septal and cal ... | 2016 | 27063794 |
| zika virus infection in pregnant women in barcelona, spain. | | 2016 | 27063354 |
| nutritional status and gross motor function in children with cerebral palsy, and implications for zika virus infection. | | 2016 | 27060691 |
| preliminary estimation of the basic reproduction number of zika virus infection during colombia epidemic, 2015-2016. | | 2017 | 27060613 |
| the south pacific epidemic strain of zika virus replicates efficiently in human epithelial a549 cells leading to ifn-β production and apoptosis induction. | zika virus (zikv) is an emerging flavivirus since the first epidemics in south pacific in 2007. the recent finding that zikv is now circulating in western hemisphere and can be associated to severe human diseases, warrants the need for its study. here we evaluate the susceptibility of human lung epithelial a549 cells to south pacific epidemic strain of zikv isolated in 2013. we showed that zikv growth in a549 cells is greatly efficient. zikv infection resulted in the secretion of ifn-β followed ... | 2016 | 27060565 |
| zika virus and pregnancy: a perspective from brazil. | | 2016 | 27060396 |
| zika virus, autoimmunity and microcephaly: other things for consideration. | | 2016 | 27060381 |
| reply concerning the article "zika virus and autoimmunity: from microcephaly to guillain-barré syndrome, and beyond". | | 2016 | 27060380 |
| new threat on the horizon: the zika virus. | | 2016 | 27058990 |
| clinical management of pregnant women exposed to zika virus. | | 2016 | 27056096 |
| zika virus and congenital malformations in perspective. | | 2016 | 27055385 |
| [zika virus: a new epidemic?]. | | 2016 | 27055374 |
| zika virus: a primer for clinicians. | the ongoing outbreak of zika virus infection that began in south america and central america in 2014 is worrisome because of associations with fetal microcephaly and with guillain-barré syndrome. here we summarize what has happened and what is known so far. as the outbreak continues to evolve, we urge clinicians to watch for updates at cdc.gov. | 2016 | 27055200 |
| vital signs: preparing for local mosquito-borne transmission of zika virus--united states, 2016. | widespread zika virus transmission in the region of the americas since 2015 has heightened the urgency of preparing for the possibility of expansion of mosquito-borne transmission of zika virus during the 2016 mosquito season. cdc and other u.s. government agencies have been working with state and local government partners on prevention and early detection of zika virus infection and will increase these activities during april as part of their preparation for the anticipated emergence of mosquit ... | 2016 | 27054688 |
| [zika virus and pregnancy]. | | 2016 | 27053037 |
| deciphering emerging zika and dengue viral epidemics: implications for global maternal-child health burden. | since its discovery in 1947 in uganda and control and eradication efforts have aimed at its vectors (aedes mosquitoes) in latin america in the 1950s, an absolute neglect of zika programs and interventions has been documented in aedes endemic and epidemic-prone countries. the current unprecedented zika viral epidemics and rapid spread in the western hemisphere pose a substantial global threat, with associated anxiety and consequences. the lack of safe and effective drugs and vaccines against zika ... | 2017 | 27052794 |
| the zika virus and pregnancy: evidence, management, and prevention. | to comprehensively review the available evidence and existing consensus reports and guidelines regarding the pregnancy and reproductive implications of the mosquito-transmitted zika virus (zikv) infection. a primary focus was to provide pertinent information to aid clinicians in the management of pregnancies at risk for, exposed to, or with confirmed zikv infection. | 2017 | 27052666 |
| guillain-barré syndrome associated with the zika virus outbreak in brazil. | zika virus (zikv) is now considered an emerging flavivirosis, with a first large outbreak registered in the yap islands in 2007. in 2013, a new outbreak was reported in the french polynesia, with associated cases of neurological complications including guillain-barré syndrome (gbs). the incidence of gbs has increased in brazil since 2015, what is speculated to be secondary to the zikv infection outbreak. the gold-standard test for detection of acute zikv infection is the polymerase-chain reactio ... | 2016 | 27050856 |
| computed tomographic findings in microcephaly associated with zika virus. | | 2016 | 27050112 |
| microcephaly and zika virus: a clinical and epidemiological analysis of the current outbreak in brazil. | this study aimed to critically review the literature available regarding the zika virus outbreak in brazil and its possible association with microcephaly cases. | 2017 | 27049675 |
| sexual transmission of zika virus: implications for clinical care and public health policy. | | 2016 | 27048746 |
| zika virus: implications for public health. | the world health organization has declared the current zika virus (zikv) epidemic a public health emergency of international concern. lack of vaccines and reliable diagnostic tests, broad geographical distribution of mosquito species that can transmit the virus, and absence of population immunity in newly affected countries are causes for concern. although most infected persons are asymptomatic, zikv has been associated with a rise in cases of neurological complications and fetal central nervous ... | 2016 | 27048745 |
| there's a new "bug" in town: what you need to know about the zika virus. | | 2016 | 27048000 |
| zika virus in the americas: a review for clinicians. | zika virus has recently emerged as a new public health threat. an arthropod-borne virus named after the zika forest in uganda, it was first discovered in 1947. the virus caused only sporadic cases of zika infection in africa and southeast asia until 2007, when the first large outbreak occurred in the yap state in the federated states of micronesia. another outbreak in french polynesia in 2013 was notable for being associated temporally with an increase in cases of guillain-barré syndrome. in 201 ... | 2016 | 27046524 |
| zika virus. | | 2016 | 27045503 |
| public health officials alarmed at spread of zika virus. | | 2016 | 27045056 |
| vectors for zika virus may spread further than was previously thought, cdc reports. | | 2016 | 27044278 |
| [provisional considerations about zika virus infection in pregnant women: document for health professionals]. | | 2016 | 27041640 |
| potential exposure to zika virus for foreign tourists during the 2016 carnival and olympic games in rio de janeiro, brazil. | | 2016 | 27040593 |
| expression analysis highlights axl as a candidate zika virus entry receptor in neural stem cells. | the recent outbreak of zika virus (zikv) in brazil has been linked to substantial increases in fetal abnormalities and microcephaly. however, information about the underlying molecular and cellular mechanisms connecting viral infection to these defects remains limited. in this study we have examined the expression of receptors implicated in cell entry of several enveloped viruses including zikv across diverse cell types in the developing brain. using single-cell rna-seq and immunohistochemistry, ... | 2016 | 27038591 |
| zika virus--pediatricians be aware. | | 2016 | 27037098 |
| microcephaly and zika virus. | | 2016 | 27036749 |
| [zika virus in a new world]. | | 2017 | 27032485 |
| [zika virus epidemic]. | zika virus is endemic in several parts of the world. february 1, 2016 zika virus was declared a public health emergency by the who. this declaration is mainly due to a convincing association between zika virus infection during pregnancy and birth defects, like microcephaly, among some of the newborns. imported cases of zika virus infection to north america, europe and denmark have been described. the infection in itself is mild and self-limiting. the available diagnostic methods are under develo ... | 2016 | 27032431 |