| ancient dna from nubian and somali wild ass provides insights into donkey ancestry and domestication. | genetic data from extant donkeys (equus asinus) have revealed two distinct mitochondrial dna haplogroups, suggestive of two separate domestication events in northeast africa about 5000 years ago. without distinct phylogeographic structure in domestic donkey haplogroups and with little information on the genetic makeup of the ancestral african wild ass, however, it has been difficult to identify wild ancestors and geographical origins for the domestic mitochondrial clades. our analysis of ancient ... | 2011 | 20667880 |
| amyloid aß , cut from app by ß-secretase bace1 and γ-secretase, induces apoptosis via opening type-1 porin/vdac in cell membranes of hypometabolic cells-a basic model for the induction of apoptosis!? | | 2010 | 20675165 |
| properties of a general pk/pd model of antibody-ligand interactions for therapeutic antibodies that bind to soluble endogenous targets. | antibodies that target endogenous soluble ligands are an important class of biotherapeutic agents. while much focus has been placed on characterization of antibody pharmacokinetics, less emphasis has been given to characterization of antibody effects on their soluble targets. we describe here the properties of a generalized mechanism-based pk/pd model used to characterize the in vivo interaction of an antibody and an endogenous soluble ligand. the assumptions and properties of the model are expl ... | 2010 | 20676036 |
| overlapping juvenile idiopathic arthritis and systemic lupus erythematosus: a case report. | hereby, we report the case of a 12-year-old girl developing oligoarthritis and progressing into a polyarticular form. rheumatoid factor was positive, and juvenile idiopathic arthritis (jia) was diagnosed. after a poor response to dmards, an anti-tnf agent (infliximab) was initiated, but to be discontinued due to an allergic reaction. the same complication was observed with the fully human derivative, adalimumab. at the age of 22, the patient presented septicemia with severe anemia and subsequent ... | 2011 | 20676642 |
| on the reactivity of sulfosalts in cyanide aqueous media: structural, bonding and electronic aspects. | the reactivity of the ruby silver minerals proustite (3ag(2)s⋅as(2)s(3)) and pyrargyrite (3ag(2)s⋅sb(2)s(3)) was studied with two types of electrodes: a carbon-paste electroactive electrode (cpee) and a paraffin-impregnated graphite electrode (pige). polycrystalline samples of α-ag(2)s (acanthite), as(2)s(3) (orpiment), sb(2)s(3) (stibnite), ag(3)ass(3) (proustite), ag(3)sbs(3) (pyrargyrite), and three samples of the proustite-pyrargyrite solid solution series were synthesized from pure elements ... | 2010 | 20677313 |
| equine trophoblast as an immunological target. | a cytotoxic t-lymphocyte assay was used to determine whether equine chorionic girdle cells are susceptible to lysis by cd8+ cytotoxic t cells primed in vitro against allogeneic lymphocytes. classical cytotoxic t-lymphocyte activity against fresh or cultured trophoblast targets was demonstrated using peripheral blood lymphocytes from nonpregnant mares. lysis of allogeneic (horse) and xenogeneic (donkey) lymphocyte targets was used as a control for trophoblast lysis. the major histocompatibility c ... | 2000 | 20681179 |
| pairing fullerenes and porphyrins: supramolecular wires that exhibit charge transfer activity. | a concept is elaborated of pairing electron donors and electron acceptors that share a common trait, wire-like features, as a powerful means to realize a new and versatile class of electron donor-acceptor nanohybrids. important variables are fine-tuning (i) the complexation strength, (ii) the electron/energy transfer behavior, and (iii) the solubilities of the resulting architectures. in particular, a series of supramolecular porphyrin/fullerene hybrids assembled by the hydrogen bonding of hamil ... | 2010 | 20681711 |
| statins for the treatment of dementia. | the use of statin therapy in established alzheimer's disease (ad) or vascular dementia (vad) is a relatively unexplored area. in ad ss-amyloid protein (ass) is deposited in the form of extracellular plaques and previous studies have determined ass generation is cholesterol dependent. hypercholesterolaemia has also been implicated in the pathogenesis of vad. due to the role of statins in cholesterol reduction it is biologically plausible they may be efficacious in the treatment of ad and dementia ... | 2010 | 20687089 |
| extended phylogeny of the equine arteritis virus sequences including south american sequences. | to perform genetic analysis of the orf5 of equine arteritis virus (eav) may provide new insights into the genetic evolution and origin of the argentinean eav sequences. | 2011 | 20689314 |
| antisense-induced guanine quadruplexes inhibit reverse transcription by hiv-1 reverse transcriptase. | guanine quadruplex structures in dna and rna affect normal cellular processes such as replication, recombination, and translation. thus, controlling guanine quadruplex structures could make it possible to manipulate the biological function of nucleic acids. here, we report a novel antisense strategy using guanine-tethered antisense oligonucleotides (g-ass) that introduces an rna-dna heteroquadruplex structure on rna templates in a predictable and sequence-specific manner, which in practice effec ... | 2010 | 20698683 |
| chromosomal assignment of r-spondin genes in the donkey (equus asinus, 2n = 62). | r-spondins constitute a recently discovered small family of growth factors, and the evidence of their role in several developmental pathways is growing fast. in this work we describe the chromosomal location of the four rspo genes in the donkey. using horse bacs, we localized rspo1 on eas 5q23, rspo2 on eas 12q13, rspo3 on eas 24q26, and rspo4 on eas 15p13. moreover, rspo2, rspo3, and rspo4 are the first genes mapped on donkey chromosomes 12, 24, and 15, respectively. | 2010 | 20720306 |
| two hypomorphic alleles of mouse ass1 as a new animal model of citrullinemia type i and other hyperammonemic syndromes. | citrullinemia type i (ctln1, omim# 215700) is an inherited urea cycle disorder that is caused by an argininosuccinate synthetase (ass) enzyme deficiency. in this report, we describe two spontaneous hypomorphic alleles of the mouse ass1 gene that serve as an animal model of ctln1. these two independent mouse mutant alleles, also described in patients affected with ctln1, interact to produce a range of phenotypes. while some mutant mice died within the first week after birth, others survived but s ... | 2010 | 20724589 |
| decision model for acute appendicitis treatment with decision tree technology--a modification of the alvarado scoring system. | how to decide the proper time to do laparotomies for acute appendicitis patients is sometimes very difficult, especially in areas with no imaging diagnostic tools. the alvarado scoring system (ass) is a convenient and inexpensive decision making tool; however, its accuracy needs to be improved. the decision tree is the most frequently used data mining technology for diagnostic model building. this study used a decision tree to modify the ass and to prioritize the variables. | 2010 | 20728850 |
| morphological and biochemical changes in the blood of horses naturally infected with gasterophilus sp. larvae. | gasterophilus sp. constitute a group of specific parasites, which larval forms are found in horses and other phylogenetically related species--donkeys, mules and zebras. their invasion is associated with marked fluctuations of hematological and biochemical blood parameters, including the activity of many enzymes and the electrolyte concentration. the purpose of the study was to analyze changes in selected biochemical and morphological blood parameters of horses infected with botfly larvae. the e ... | 2010 | 20731178 |
| a secondary antibody format chemiluminescence immunoassay for the determination of estradiol in human serum. | a competitive immunoassay for estradiol (e2) based on secondary antibody format was established. the donkey anti-rabbit igg was used as the secondary antibody to coat micro-plates, and the horseradish peroxidase (hrp)-luminol-h(2)o(2) chemiluminescent system with high sensitivity was chosen as the detection system. the addition of sodium trichloroacetate (ccl(3)coona) in the enzyme buffer as a replaceable packing material can realize directly analysis of e2 in human serum without extraction, whi ... | 2010 | 20801358 |
| l-citrulline attenuates arrested alveolar growth and pulmonary hypertension in oxygen-induced lung injury in newborn rats. | bronchopulmonary dysplasia (bpd) is characterized by arrested alveolar development and complicated by pulmonary hypertension (ph). nitric oxide (no) promotes alveolar growth. inhaled no (ino) ameliorates the bpd phenotype in experimental models and in some premature infants. arginosuccinate synthetase (ass) and arginosuccinate lyase (asl) convert l-citrulline to l-arginine; l-citrulline is regenerated during no synthesis from l-arginine. plasma levels of these no precursors are low in ph. we hyp ... | 2010 | 20805789 |
| micromorphology of resin-dentin interfaces using one-bottle etch&rinse and self-etching adhesive systems on laser-treated dentin surfaces: a confocal laser scanning microscope analysis. | this study evaluated the hybrid layer (hl) morphology created by three adhesive systems (as) on dentin surfaces treated with er:yag laser using two irradiation parameters. | 2010 | 20806391 |
| [an indirect elisa for the detection of babesia caballi in equine animals]. | to clone and express bc48 gene of babesia caballi, and to establish an indirect elisa for the diagnosis of b. caballi in equine animals. | 2010 | 20806504 |
| colorimetric detection of achiral anions and chiral carboxylates by a chiral thiourea-phthalimide dyad. | the chiral chemosensor 1, based on a thiourea-activated phthalimide, is available by four reaction steps from 4-nitrophthalimide. 1 detects fluoride, chloride, acetate, and dihydrogen phosphate anions by changes in uv-vis absorption. fluoride in excess induces deprotonation whereas the other anions show only complex formation in the ground state. (1)h-nmr studies confirm the formation of these h-bonded complexes and the fluoride-induced receptor deprotonation in the recognition process. moderate ... | 2010 | 20820676 |
| measurement of thyroid hormones in donkey (equus asinus) blood and milk: validation of elisa kits and evaluation of sample collection, handling and storage. | donkey's milk is well tolerated by human infants with cow's milk allergy and is useful in the treatment of human immune-related diseases and in the prevention of atherosclerosis. thyroid hormones (th) stimulate lactation and active triiodothyronine (t3) in colostrum and milk could take paracrine action supporting lactogenesis in the mother, and play physiological roles for the suckling offspring (systemic or within the gastrointestinal tract). the aims were to measure th concentrations in donkey ... | 2010 | 20822570 |
| [cyclopentadienyl]metalcarbonyl complexes of acetylsalicylic acid as neo-anticancer agents. | [(prop-2-ynyl)-2-acetoxybenzoate]dicobalthexacarbonyl (co-ass), a derivative of the nonsteroidal anti-inflammatory drug aspirin(®) (ass), demonstrated high cytotoxic potential against various tumor cells. the [acetylene]co(2)(co)(6) cluster strongly increased the biological effects compared to aspirin(®). in this study we evaluated the use of [cyclopentadienyl]metalcarbonyl as cytotoxic moiety with a broader series of metals: molybdenum, manganese, cobalt and rhodium. all compounds were tested f ... | 2010 | 20828891 |
| nasal bots...a fascinating world! | larvae causing obligatory myiasis are numerous and they may affect cutaneous and subcutaneous tissues, wounds, nasopharyngeal cavities (nasal bots), internal organs and the digestive tract (bots) of domestic and wild animals and humans as well. nasal bots belong to the family oestridae, subfamily oestrinae, which includes several important genera: oestrus, kirkioestrus, and gedoelstia infecting artiodactyla (except cervidae) in africa and eurasia, cephenemyia and pharyngomyia infecting cervidae, ... | 2010 | 20837381 |
| tick-borne rickettsioses, neglected emerging diseases in rural senegal. | rickettsioses are one of the most important causes of systemic febrile illness among travelers from developed countries, but little is known about their incidence in indigenous populations, especially in west africa. | 2010 | 20856858 |
| synthesis and biological activities of transition metal complexes based on acetylsalicylic acid as neo-anticancer agents. | [(μ(4)-η(2))-(prop-2-ynyl)-2-acetoxybenzoate]dicobalthexacarbonyl (co-ass), a derivative of aspirin (ass), demonstrated high growth-inhibitory potential against various tumor cells with interference in the arachidonic acid cascade as probable mode of action. the significance of the kind of metal and cluster was verified in this structure-activity study: co(2)(co)(6) was respectively exchanged by a tetrameric cobalt-, trimeric ruthenium-, or trimeric ironcarbonyl cluster. furthermore, the metal b ... | 2010 | 20857911 |
| anti-11[e]-pyroglutamate-modified amyloid β antibodies cross-react with other pathological aβ species: relevance for immunotherapy. | n-truncated/modified forms of amyloid beta (aß) peptide are found in diffused and dense core plaques in alzheimer's disease (ad) and down's syndrome patients as well as animal models of ad, and represent highly desirable therapeutic targets. in the present study we have focused on n-truncated/modified aβ peptide bearing amino-terminal pyroglutamate at position 11 (aβn11(pe)). we identified two b-cell epitopes recognized by rabbit anti-aβn11(pe) polyclonal antibodies. interestingly, rabbit anti-a ... | 2010 | 20864186 |
| erythrocyte permeability to urea and water: comparative study in rodents, ruminants, carnivores, humans, and birds. | mammalian erythrocytes exhibit high urea permeability (p (urea)) due to ut-b expression in their cytoplasmic membrane. this high p (urea) allows fast equilibration of urea in erythrocytes during their transit in the hyperosmotic renal medulla. it also allows more urea (in addition to that in plasma) to participate in counter-current exchange between ascending and descending vasa recta, thus improving the trapping of urea in the medulla and improving urine concentrating ability. to determine if p ... | 2010 | 20878327 |
| amino acid mutations in the env gp90 protein that modify n-linked glycosylation of the chinese eiav vaccine strain enhance resistance to neutralizing antibodies. | the chinese eiav vaccine is an attenuated live-virus vaccine obtained by serial passage of a virulent horse isolate (eiav(l)) in donkeys (eiav(d)), and subsequently in donkey cells in vitro. in this study, we compare the env gene of the original horse virulent virus (eiav(l)) with attenuated strains serially passaged in donkey mdm (eiav(dlv)), and donkey dermal cells (eiav(fddv)). genetic comparisons among parental and attenuated strains found that vaccine strains contained amino acid substituti ... | 2010 | 20883167 |
| hygienic and health characteristics of donkey milk during a follow-up study. | for its characteristics, donkey milk has been proposed as an alternative to goat or artificial milk to feed allergic infants. therefore, it is important to increase our knowledge on health and immunological characteristics of donkey milk. ten donkeys, bred as companion animals, were enrolled in this study and sampled once a month, for eight months. milk (10 ml) was collected from each half udder for somatic cell count (scc), bacteriological analysis and total bacteria count (tbc). the major path ... | 2010 | 20883563 |
| [the efficacy of anthelmintic drugs against horse strongyles in the area of salzburg and preliminary results of selective anthelmintic treatment]. | in recent years more and more cases of anthelmintic resistant equine strongyles were reported. the latest developments are cases of resistance against macrocyclic lactones. in order to delay this process less anthelmintics and only those which have been previously tested for their efficacy on each individual farm should be used. during the grazing season 2008 faecal samples of 281 horses and 5 donkeys from 26 farms were analysed in the area of salzburg. to 164 of these horses selective anthelmin ... | 2010 | 20924696 |
| longitudinal study of an outbreak of trypanosoma evansi infection in equids and dromedary camels in israel. | an outbreak of trypanosomoasis caused by trypanosoma evansi involving horses, camels and donkeys occurred in a farm in israel. a longitudinal study of two outbreak phases was conducted which included clinical monitoring, blood smears, packed cell volume (pcv), serology and polymerase chain reaction (pcr) followed by reverse dot blot (rdb) for the molecular detection of infection. this was the first reported t. evansi outbreak in domestic animals in israel. most of the camels on the farm (8/10; 8 ... | 2010 | 20926194 |
| antibody to the e3 glycoprotein protects mice against lethal venezuelan equine encephalitis virus infection. | six monoclonal antibodies were isolated that exhibited specificity for a furin cleavage site deletion mutant (v3526) of venezuelan equine encephalitis virus (veev). these antibodies comprise a single competition group and bound the e3 glycoprotein of veev subtype i viruses but failed to bind the e3 glycoprotein of other alphaviruses. these antibodies neutralized v3526 virus infectivity but did not neutralize the parental strain of trinidad donkey (trd) veev. however, the e3-specific antibodies d ... | 2010 | 20926570 |
| feno as a marker of airways inflammation: the possible implications in childhood asthma management. | the aim of this study was to verify feno usefulness, as a marker of bronchial inflammation, in the assessment of therapeutic management of childhood asthma. we performed a prospective 1-year randomized clinical trial evaluating two groups of 32 children with allergic asthma: "gina group", in which therapy was assessed only by gina guidelines and "feno group", who followed a therapeutic program assessed also on feno measurements. asthma severity score (ass), asthma exacerbation frequency (aef), a ... | 2010 | 20948878 |
| allicin can reduce neuronal death and ameliorate the spatial memory impairment in alzheimer's disease models. | to investigate the mechanisms and protective effects of allicin on learning and memory in a mouse model of alzheimer's disease (ad). | 2010 | 20956919 |
| whey protein-okra polysaccharide fraction blend edible films: tensile properties, water vapor permeability and oxygen permeability. | a hot-buffer-soluble-solid fraction (hbss) and an alkaline-soluble-solid fraction (ass) of okra polysaccharides (okp) were obtained using sequential extraction. these fractions were combined with whey protein isolate (wpi) and glycerol (gly) plasticizer to form blend edible films. effects of okp fraction and content on tensile properties, water vapor permeability (wvp) and oxygen permeability (op) were determined. | 2011 | 20960421 |
| glanders in the ass. | | 1945 | 21013331 |
| epigenetic modification is linked to alzheimer's disease: is it a maker or a marker? | alzheimer's disease (ad) is the most common age-dependent neurodegenerative disorder and shows progressive memory loss and cognitive decline. intraneuronal filaments composed of aggregated hyperphosphorylated tau protein, called neurofibrillary tangles, along with extracellular accumulations of amyloid ß protein (aß), called senile plaques, are known to be the neuropathological hallmarks of ad. in light of recent studies, epigenetic modification has emerged as one of the pathogenic mechanisms of ... | 2010 | 21034526 |
| change in plasma aß peptides and onset of dementia in adults with down syndrome. | to examine changes in levels of plasma amyloid-β (aβ) peptides, aβ42 and aβ40, in relation to onset of alzheimer disease (ad) in adults with down syndrome (ds). | 2010 | 21041786 |
| [novel anticoagulants for stroke prevention in atrial fibrillation]. | the most frequent cardiac arrhythmia and main cause for cardio-embolic stroke is atrial fibrillation. prophylaxis for thrombembolic events is performed regarding individual risk of patients with either ass or vitamin-k-antagonists. efficacy and safety of oral anticoagulation is limited by a narrow therapeutical range as well as by inter- and intraindividual variability of inr-values due to genetic disposition, differences in alimentation, dosage errors, rare control of inr-levels and drug-intera ... | 2010 | 21064013 |
| assessment of the potential for displacement interactions with sugammadex: a pharmacokinetic-pharmacodynamic modelling approach. | sugammadex is a γ-cyclodextrin that binds with high affinity to the neuromuscular blocking agents (nmbas) rocuronium (bromide) and vecuronium (bromide) by encapsulation. cyclodextrins are known to form inclusion complexes with other compounds. | 2011 | 21067251 |
| gluts and mammalian sperm metabolism. | mammalian cells use glucides as a substrate that can be catabolized through glycolitic pathways or oxidative phosphorylation, used as a source of reducing potential, or used for anabolic aims. an important role in supplying cells with energy is played by different membrane proteins that can actively (sodium-dependent glucose transporters) or passively (glucose transporters; glut) transport hexoses through the lipidic bilayer. in particular, gluts are a family of 13 proteins that facilitate the t ... | 2010 | 21088231 |
| realgar- and cinnabar-containing an-gong-niu-huang wan (agnh) is much less acutely toxic than sodium arsenite and mercuric chloride. | an-gong-niu-huang wan (agnh) is a famous traditional chinese medicine used for brain trauma, hemorrhage, and coma. agnh contains 10% realgar (as₄s₄) and 10% cinnabar (hgs). both as and hg are well-known for their toxic effects, and the safety of agnh is of concern. to address this question, the acute toxicity of agnh, realgar and cinnabar were compared to sodium arsenite (naaso₂) and mercuric chloride (hgcl₂). mice were administrated orally agnh at 1, 3 and 6g/kg. agnh at 3g/kg contains 2.8mmol ... | 2010 | 21094152 |
| inhibition of chymotrypsin- and subtilisin-like serine proteases with tk-serpin from hyperthermophilic archaeon thermococcus kodakaraensis. | a serpin homologue (tk-serpin) from the hyperthermophilic archaeon thermococcus kodakaraensis was overproduced in e. coli, purified, and characterized. tk-serpin irreversibly inhibits tk-subtilisin (tks) from the same organism with the second-order association rate constants (k(ass)) of 5.2×10³ m⁻¹ s⁻¹ at 40°c and 3.1×10⁵ m⁻¹ s⁻¹ at 80°c, indicating that tk-serpin inhibits tks more strongly at 80°c than at 40°c. it also irreversibly inhibits chymotrypsin, subtilisin carlsberg, and proteinase k a ... | 2010 | 21112419 |
| descriptive epidemiology of equine influenza in india (2008-2009): temporal and spatial trends. | equine influenza is a contagious viral disease that affects all members of the family equidae, i.e., horses, donkeys and mules. the authors describe the pattern of equine influenza outbreaks in a number of states of india from july 2008 to june 2009. the disease was first reported in june 2008 in katra (jammu and kashmir) and spread to ten other states within a year. all outbreaks of equine influenza in the various states were confirmed by laboratory investigations (virus isolation and/or serolo ... | 2010 | 21120800 |
| anti-jo-1 antisynthetase syndrome. | given a lack of population-based studies, we report an epidemiological-clinic study of anti-jo-1 antisynthetase syndrome (ass). | 2010 | 21125186 |
| steady-state and time-resolved investigations of a crown thioether conjugated with methylacridinium and its complexes with metal ions. | the crown thioether 9-[4-(4,7,10,13-tetrathia-1-azacyclopentadecyl]phenyl-n-methylacridinium perchlorate (tcma) was synthesized and characterized with the aim to verify its ability to interact selectively with metal ions and substantiate the possibility to detect easily the presence of heavy metals in fluid samples. the spectroscopic properties of tcma, alone and in the presence of metal ions, were therefore studied in polar solvents (mecn and h(2)o); in particular, steady-state uv-vis spectroph ... | 2010 | 21127778 |
| state trait anxiety in the emergency department: an analysis of anticipatory and life stressors. | to determine the relationship between stress indicators and state anxiety among pediatric emergency department (ed) patients, as a background to develop appropriate psychoeducational and behavioral interventions. | 2010 | 21131802 |
| brain nitric oxide production by a proline-rich decapeptide from bothrops jararaca venom improves baroreflex sensitivity of spontaneously hypertensive rats. | baroreflex sensitivity is disturbed in many people with cardiovascular diseases such as hypertension. brain deficiency of nitric oxide (no), which is synthesized by no synthase (nos) in the citrulline-no cycle (with argininosuccinate synthase (ass) activity being the rate-limiting step), contributes to impaired baroreflex. we recently showed that a decapeptide isolated from bothrops jararaca snake venom, denoted bj-pro-10c, exerts powerful and sustained antihypertensive activity. bj-pro-10c prom ... | 2010 | 21132021 |
| genomic comparison between attenuated chinese equine infectious anemia virus vaccine strains and their parental virulent strains. | a lentiviral vaccine, live attenuated equine infectious anemia virus (eiav) vaccine, was developed in the 1970s, and this has made tremendous contributions to the control of equine infectious anemia (eia) in china. four key virus strains were generated during the attenuation of the eiav vaccine: the original liao-ning strain (eiav(ln40)), a donkey-adapted virulent strain (eiav(dv117)), a donkey-leukocyte-attenuated vaccine strain (eiav(dlv121)), and a fetal donkey dermal cell (fdd)-adapted vacci ... | 2010 | 21136127 |
| targeted cellular metabolism for cancer chemotherapy with recombinant arginine-degrading enzymes. | it has been shown that a subset of human cancers, notably, melanoma and hepatocellular carcinoma (hcc) are auxotrophic for arginine (arg), because they do not express argininosuccinate synthetase (ass), the rate-limiting enzyme for the biosynthesis of arginine from citrulline. these ass-negative cancer cells require arg from extracellular sources for survival. when they are exposed to recombinant arg-degrading enzymes, e.g. arginine deiminase (adi) or arginase, they die because of arg starvation ... | 2010 | 21152246 |
| tailoring immobilization of immunoglobulin by excimer laser for biosensor applications. | the sheltered transfer and immobilization of rabbit anti-human antiserum immunoglobulin g (igg) by matrix-assisted pulsed laser evaporation (maple) are reported. the iced targets submitted to laser irradiation consisted of 0.2-2 mg/ml igg blended or not with lipid (l-α-phosphatidylcholine dipalmitoyl) dissolved in distilled water-based saline buffer. thin igg coatings were obtained at room temperature onto glass, fused silica, or silicon substrates. ten thousand subsequent laser pulses of 0.33, ... | 2010 | 21154455 |
| a pericentric inv(9)(p22q34) of the der(9)t(9;22)(q34;q11.2) is a recurrent secondary anomaly in ph-positive leukemia. | a pericentric inv(9)(p22q34) of the derivative chromosome 9 that resulted from a standard t(9;22)(q34;q11.2) was identified by r-banding karyotypic analysis and fluorescence in situ hybridization (fish) assays in 4 (0.18%) of 2,200 philadelphia chromosome (ph)-positive leukemia patients, including 3 with chronic myeloid leukemia (cml) in chronic phase and 1 with acute myeloid leukemia (aml) in our hospital since 2004. all four patients had two malignant clones: one with only t(9;22)(q34;q11.2) a ... | 2010 | 21156255 |
| immunotherapy for alzheimer's disease. | in the year 1999, a vaccine approach was found to reduce amyloid deposits in transgenic mice overproducing the amyloid precursor protein. this was followed closely by demonstrations that vaccines or passive immunotherapy could rescue memory deficits in these mice. initial human clinical trials revealed apparent autoimmune reactions in a subset of patients, but also some cases of cognitive benefit and amyloid clearance. further work with passive immunotherapy in mouse models confirmed exceptional ... | 2011 | 21158978 |
| [inhibitive effect of acanthopanax senticosus injection on gentamicin-induced ototoxicity in guinea pigs]. | to study the antagonistic action of acanthopanax senticosus injection (ass) on gentamicin ototoxicity. | 2006 | 21162254 |
| tailoring immobilization of immunoglobulin by excimer laser for biosensor applications. | the sheltered transfer and immobilization of rabbit anti-human antiserum immunoglobulin g (igg) by matrix-assisted pulsed laser evaporation (maple) are reported. the iced targets submitted to laser irradiation consisted of 0.2-2 mg/ml igg blended or not with lipid (l-α-phosphatidylcholine dipalmitoyl) dissolved in distilled water-based saline buffer. thin igg coatings were obtained at room temperature onto glass, fused silica, or silicon substrates. ten thousand subsequent laser pulses of 0.33, ... | 2010 | 21171158 |
| glycomics of a novel type-2 n-acetyllactosamine-specific lectin purified from the feather star, oxycomanthus japonicus (pelmatozoa: crinoidea). | a lectin - designated oxyl for the purposes of this study that strongly recognizes complex-type oligosaccharides of serum glycoproteins - was purified from a crinoid, the feather star oxycomanthus japonicus, the most basal group among extant echinoderms. oxyl was purified through a combination of anion-exchange and affinity chromatography using q-sepharose and fetuin-sepharose gel, respectively. lectin was determined to be a 14-kda polypeptide by sodium dodecyl sulphate-polyacrylamide gel electr ... | 2010 | 21176791 |
| authentication of the 31 species of toxic and potent chinese materia medica by microscopic technique assisted by icp-ms analysis, part 4: four kinds of toxic and potent mineral arsenical cmms. | toxic and potent chinese materia medica (t/pcmm) is a special and very important category of chinese medicines. they have long been used in traditional medical practice and are being used more and more widely throughout the world in recent years. as there may be many fatal toxic effects caused by misusing or confusion of t/pcmm, their quality and safety control arouse increasing attention internationally. researches on the accurate identification to ensure the safe use of t/pcmm are acquired; ho ... | 2011 | 21181703 |
| three-dimensional imaging of ventricular activation and electrograms from intracavitary recordings. | three-dimensional (3-d) mapping of the ventricular activation is of importance to better understand the mechanisms and facilitate management of ventricular arrhythmias. the goal of this study was to develop and evaluate a 3-d cardiac electrical imaging (3dcei) approach for imaging myocardial electrical activation from the intracavitary electrograms (egs) and heart-torso geometry information over the 3-d volume of the heart. the 3dcei was evaluated in a swine model undergoing intracavitary noncon ... | 2010 | 21189233 |
| epidemiology of equine sarcoids in horses in western canada. | sarcoids are the most common tumor of the equine skin but only 1 study describing the epidemiology of sarcoids in canadian horses has been published. the records of 5 veterinary diagnostic laboratories in western canada were searched to identify submissions of sarcoids from horses. the submission records and diagnostic reports of 802 separate submissions of equine sarcoids were reviewed for age, breed, and gender of the horse and the number, location, and clinical type of sarcoid. from these rec ... | 2010 | 21197201 |
| reinvestigation of the crystal structure of lautite, cuass. | the crystal structure of the mineral lautite (copper arsenic sulfide), cuass, previously described as either centrosymmetric [pnma; marumo & nowacki (1964 ▶). schweiz. miner. petro. mitt.44, 439-454] or noncentrosymmetric [pna2(1); craig & stephenson (1965 ▶). acta cryst.19, 543-547], was reinvestigated by means of single-crystal x-ray diffraction. the centrosymmetric structural model reported previously was confirmed, although with improved precision for the atomic coordinates and inter-atomic ... | 2008 | 21201839 |
| a randomized triple blind trial to assess the effect of an anthelmintic programme for working equids in morocco. | gastro-intestinal parasitism has been identified as a significant cause of disease in working equids in many countries. this randomized triple-blind trial was designed to assess the impact of an anthelmintic treatment programme (using oral ivermectin and fenbendazole) comparing treated and placebo control populations of working donkeys, mules and horses in field conditions in morocco. in particular, we assessed animal body weight and condition score, together with a questionnaire-based owner eva ... | 2011 | 21208398 |
| kinetics and solvent-dependent thermodynamics of water capture by a fullerene-based hydrophobic nanocavity. | kinetic and thermodynamic properties of water encapsulation from organic solution by an open-cage [60]fullerene derivative have been investigated. 2d exchange nmr spectroscopy (exsy) measurements were employed to determine the association and dissociation constants at 300-330 k (k(a) = 4.3 m(-1) × s(-1) and k(d) = 0.42 s(-1) at 300 k) in 1,1,2,2-tetrachloroethane-d(2) as well as the activation energies (e(a,ass) = 27 kj mol(-1), e(a,diss) = 50 kj mol(-1)). the equilibrium constants and thermodyn ... | 2011 | 21214281 |
| efficacy of eprinomectin pour-on against dictyocaulus arnfieldi infection in donkeys (equus asinus). | a trial to assess the efficacy of eprinomectin (epm) against the lungworm dictyocaulus arnfieldi was carried out on 15, naturally-infected donkeys. ten animals were treated with a 'pour-on' epm preparation (at a dose of 0.5mg/kg bodyweight), and five animals acted as controls. faecal larval counts were carried out two days before treatment, on day of treatment and 7, 14, 21 and 28days post-treatment with the anthelmintic. epm was 100% effective in eliminating faecal larvae from day 7, until the ... | 2011 | 21216164 |
| on the in vivo early toxic properties of a-beta 25-35 peptide in the rat hippocampus: involvement of the receptor-for-advanced glycation-end-products and changes in gene expression. | amyloid-beta peptide (aβ) deposition is assumed to play a pathogenic role in the brain of alzheimer's disease patients. to date, the precise mechanisms underlying aβ toxicity are not fully understood. a recent hypothesis suggesting that the receptor-for-advanced-glycation-end-products (rage)-a trans-membrane protein signaling for oxidative stress-is involved in aβ toxicity is gaining attention. early aβ toxicity could indeed help to explain the deleterious events further produced by this molecul ... | 2011 | 21216281 |
| evaluation of overnight hold of whole blood at room temperature before component processing: effect of red blood cell (rbc) additive solutions on in vitro rbc measures. | whole blood (wb) can be held at room temperature (18-25°c) up to 8 hours after collection; thereafter the unit must be refrigerated, rendering it unsuitable for platelet (plt) production. overnight hold at room temperature before processing has logistic advantages, and we evaluated this process in an international multicenter study for both buffy coat (bc)- and plt-rich plasma (prp)-based blood components and compared three red blood cell (rbc) additive solutions (ass) for their ability to offse ... | 2011 | 21223291 |
| ultrasensitively sensing acephate using molecular imprinting techniques on a surface plasmon resonance sensor. | an ultrathin molecularly imprinted polymer film was anchored on an au surface for fabricating a surface plasmon resonance sensor sensitive to acephate by a surface-bound photo-radical initiator. the polymerization in the presence of acephate resulted in a molecular-imprinted matrix for the enhanced binding of acephate. analysis of the spr wavenumber changes in the presence of different concentrations of acephate gave a calibration curve that included the ultrasensitive detection of acephate by t ... | 2010 | 21238731 |
| study of non-covalent interactions of luotonin a derivatives and the dna minor groove as a first step in the study of their analytical potential as dna probes. | the interaction between dna and several newly synthesized derivatives of the natural anticancer compound luotonin a has been studied. the results from our work reveal an effective and selective alkaloid/double-stranded dna (ds-dna) interaction. in the presence of increasing amounts of ds-dna, a noticeable fluorescence quenching of the luotonin a derivatives under study was observed. however, this effect did not take place when single-stranded dna (ss-dna) was employed. the association constant a ... | 2011 | 21243339 |
| biological aspects on dictyocaulus arnfieldi. | in the postmortem examination of 54 adult donkeys slaughtered for the carnivore animals in kafr el-sheikh zoological garden, dictyocaulus arnfieldi (cobbold, 1884) railliet and henry, 1907 was demonstrated in their lungs. the biological data of the different developmental stages were recorded and discussed, where the period required for maturation, hatching and development of 2nd and 3rd stage larvae was 84 hours, general discussion was given. | 2010 | 21246946 |
| anti-toxoplasma gondii antibodies in working donkeys and donkey's milk in greater cairo, egypt. | toxoplasma gondii is one of the important zoonotic parasites of worldwide zoological & geographical distribution. elisa prevalence of toxoplasma gondii in egyptian locally bred working donkeys in greater cairo was evaluated. the donkeys were 75 females & 25 males aged between 3-10 years. the results showed that elisa antibodies of t. gondii were found in 45 out of 100 (45%) working donkeys. donkeys' milk obtained from fifteen pregnant females was t. gondii positive in seven (46.3%). the zoonotic ... | 2010 | 21246953 |
| rejuvenation capacity of red blood cells in additive solutions over long-term storage. | red blood cells (rbcs) are food and drug administration (fda)-approved for 42-day storage with the use of additive solutions (ass). however, adenosine triphosphate (atp) and 2,3-diphosphoglycerate (2,3-dpg) levels in the rbcs decline over this time. these constituents may be restored by treatment with rejuvenation (rej) solutions. this study was done to assess the response capability of rbcs from 30 to 120 days of storage in three fda-licensed rbc storage solutions after incubation with a rejuve ... | 2011 | 21251004 |
| an overview of the epidemic of highly pathogenic h5n1 avian influenza virus in egypt: epidemiology and control challenges. | emergence of the highly pathogenic avian influenza (hpai) h5n1 virus in egypt in mid-february 2006 caused significant losses for the poultry industry and constituted a potential threat to public health. since late 2007, there has been increasing evidence that stable lineages of h5n1 viruses are being established in chickens and humans in egypt. the virus has been detected in wild, feral and zoo birds and recently was found in donkeys and pigs. most of the outbreaks in poultry and humans occurred ... | 2011 | 21281550 |
| stress echocardiography in differentiation of fixed vs. low flow-low gradient and pseudo severe aortic stenosis. | to present the importance of stress echocardiography in diagnosis of low flow-low gradient aortic stenosis (as). | 2010 | 21287957 |
| platelet aggregation inhibitors in primary and secondary prevention of ischemic stroke. | the ischaemic stroke (is) is one of the most frequent cause of death in germany. besides of non-drug many drug-based interventions are used in primary or secondary prevention of is, among them the thrombocyte aggregation inhibitors (tai). | 2006 | 21289960 |
| pgf(2a), lh, testosterone, oestrone sulphate, and cortisol plasma concentrations around sexual stimulation in jackass. | many hormones are involved in the regulation of male reproductive functions, controlling sexual behavior, and influencing sexual arousal, the onset of erection and ejaculation, and the post-ejaculatory detumescence. the aims of this study were to analyze the plasma concentrations of 15-ketodihydro-pgf(2a) (pgfm), lh, testosterone (t), oestrone sulphate (os), and cortisol (c) in relation to sexual stimulation and to evaluate the possible correlations among circulating hormones and between hormone ... | 2011 | 21295832 |
| normal atmospheric oxygen tension and the use of antioxidants improve hepatocyte spheroid viability and function. | background: hepatocyte spheroids have been proposed for drug metabolism studies and in bioartificial liver devices. however, the optimal conditions required to meet the aerobic demands of mitochondria-rich hepatocyte spheroids is not well studied. we hypothesized that an optimal concentration of oxygen could be identified and that the health of hepatocyte spheroids might be further improved by antioxidant therapy. methods: rat hepatocyte spheroids were maintained in suspension culture for 7 days ... | 2011 | 21302300 |
| recognition of polycyclic aromatic hydrocarbons and their derivatives by the 1,3-dinaphthalimide conjugate of calix[4]arene: emission, absorption, crystal structures, and computational studies. | polycyclic aromatic hydrocarbons (pahs) are environmental pollutants as well as well-known carcinogens. therefore, it is important to develop an effective receptor for the detection and quantification of such molecules in solution. in view of this, a 1,3-dinaphthalimide derivative of calix[4]arene (l) has been synthesized and characterized, and the structure has been established by single crystal xrd. in the crystal lattice, intermolecular arm-to-arm p···p overlap dominates and thus l becomes a ... | 2011 | 21314094 |
| quantitative real time polymerase chain reaction assays for the sensitive detection of besnoitia besnoiti infection in cattle. | bovine besnoitiosis, an economically important disease in cattle in some countries of africa and asia, is emerging in europe. the definitive host of besnoitia besnoiti, the causative agent of bovine besnoitiosis, is unknown and the transmission of the parasite is not completely understood. sensitive and quantitative dna detection methods are needed to determine whether serologically positive animals are infectious and to examine the role of vectors (e.g. haematophagous insects) in the transmissi ... | 2011 | 21324596 |
| chemokine saliva levels in patients with primary sjögren's syndrome, associated sjögren's syndrome, pre-clinical sjögren's syndrome and systemic autoimmune diseases. | to assess the saliva levels of cxcl13, cxcl10, ccl2, ccl3, cxcl12 and ccl5 in patients with primary ss (pss), patients with associated ss (ass), patients with systemic autoimmune disease (sad) without ss, pre-clinical ss and healthy controls. | 2011 | 21330342 |
| use of biosensors to measure the kinetics of antibody-antigen interactions. | the affinity and kinetics of antibody-antigen interactions are increasingly realized to be important parameters in determining the usefulness of antibodies in both in vivo and in vitro settings (1). as discussed in chapter 1, the affinity of an antibody (given by the association or dissociation equilibrium constants; ka and k(d)) gives information about how much antibody will be bound to the antigen at equilibrium, or how much antibody will be required for a particular proportion of the antigen ... | 2000 | 21337107 |
| a retrospective longitudinal study of animal and human rabies in botswana 1989-2006. | a longitudinal study of animal and human rabies covering 18 years from 1989 to 2006 was retrospectively conducted in order to highlight the epidemiological features and trends of the disease in botswana. over the 18-year period, a total of 4 306 brain specimens collected from various species of animals including human beings with clinical signs consistent with rabies were submitted to the national veterinary laboratory in gaborone for confirmatory diagnosis. of the samples submitted, 2419 cases ... | 2009 | 21344790 |
| alternative stable states generated by ontogenetic niche shift in the presence of multiple resource use. | it has been suggested that when juveniles and adults use different resources or habitats, alternative stable states (ass) may exist in systems coupled by an ontogenetic niche shift. however, mainly the simplest system, i.e., the one-consumer-two-resource system, has been studied previously, and little is known about the development of ass existing in more complex systems. here, i theoretically investigated the development of ass caused by an ontogenetic niche shift in the presence of multiple re ... | 2011 | 21346805 |
| cross-species surveillance of leptospira in domestic and peri-domestic animals in mahalla city, gharbeya governorate, egypt. | a survey of 179 animals (black rats, dogs, sheep, buffaloes, cattle, donkeys, weasels, and cats) for leptospira infection was conducted in mahalla city (lower egypt). blood, urine, and kidney were collected and tested by culture, microscopic agglutination test (mat), and/or polymerase chain reaction (pcr). among rats, 26% were positive by pcr, including 7% that were also positive by culture for l. interrogans serovars grippotyphosa, pyrogenes, and icterohaemorrhagiae. l. borpetersenii serovar po ... | 2011 | 21363980 |
| the nature of intermediate-range order in ge-as-s glasses: results from reverse monte carlo modeling. | the experimental neutron and x-ray diffraction data for stoichiometric and s-deficient ge(x)as(x)s(100-2x) glasses with x = 18.2, 25.0, and 33.3 at.% have been modeled simultaneously using the reverse monte carlo (rmc) technique. nearest-neighbor coordination environments, as obtained in previous x-ray absorption spectroscopy and diffraction experiments, have been employed as short-range order constraints in these simulations. the large scale three-dimensional structural models thus obtained fro ... | 2010 | 21389466 |
| equine hyperlipidemias. | hyperlipidemia is the presence of elevated lipid concentrations in the blood and is associated with periods of negative energy balance and physiologic stress. in increased concentrations, circulating lipids typically occur in the triglyceride form, which may interfere with numerous normal physiologic functions, particularly by reducing insulin sensitivity. although the hyperlipidemia risk is greatest in ponies, miniature horses, and donkeys, all equids are at risk if they are in a situation invo ... | 2011 | 21392654 |
| expression of a constitutively active calcineurin encoded by an intron-retaining mrna in follicular keratinocytes. | hair growth is a highly regulated cyclical process. immunosuppressive immunophilin ligands such as cyclosporin a (csa) and fk506 are known as potent hair growth modulatory agents in rodents and humans that induce active hair growth and inhibit hair follicle regression. the immunosuppressive effectiveness of these drugs has been generally attributed to inhibition of t cell activation through well-characterized pathways. specifically, csa and fk506 bind to intracellular proteins, principally cyclo ... | 2011 | 21423799 |
| ultrasensitive ce for heavy metal ions using the variations in the chemical structures formed from new octadentate fluorescent probes and cationic polymers. | novel fluorescent probes have been developed for the ultratrace detection of heavy metal ions by capillary electrophoresis using laser-induced fluorescence detection. based on a molecular design, the probes are composed of an octadentate chelating moiety, a macrocyclic dota (tetraazacyclododecanetetraacetic acid) and an acyclic dtpa (diethylenetriaminepentaacetic acid) frame, a spacer and a fluorophore (fluorescein). these were chosen on the basis of their ability to form kinetically inert and h ... | 2011 | 21423963 |
| induction of arginosuccinate synthetase (ass) expression affects the antiproliferative activity of arginine deiminase (adi) in melanoma cells. | arginine deiminase (adi), an arginine-degrading enzyme, has been used in the treatment of tumours sensitive to arginine deprivation, such as malignant melanoma (mm) and hepatocellular carcinoma (hcc). endogenous production of arginine is mainly dependent on activity of ornithine transcarbamylase (otc) and argininosuccinate synthetase (ass) enzymes. we evaluated the effect of adi treatment on otc and ass expression in a series of melanoma cell lines. twenty-five primary melanoma cell lines and no ... | 2011 | 21424129 |
| comparison of major lipid components in human and donkey milk: new perspectives for a hypoallergenic diet in humans. | recently, donkey milk has been indicated as a nutraceutical food thanks to some bioactive compounds interesting in the human diet; these substances are the lipids, which are characterized by the ability in conditioning indirectly or directly the intestinal environment and immunity, taking part in the prevention and treatment of some pathologies. with the aim to compare some nutritional properties of human and donkey milk, the triacylglycerol (tag) composition and the positional isomers of donkey ... | 2011 | 21428711 |
| the lipid composition of a cell membrane modulates the interaction of an antiparasitic peptide at the air-water interface. | the antiparasitic property of peptides is believed to be associated with their interactions with the protozoan membrane, which calls for research on the identification of membrane sites capable of peptide binding. in this study we investigated the interaction of a lipophilic glutathioine peptide known to be effective against the african sleeping sickness (ass - african trypanosomiasis) and cell membrane models represented by langmuir monolayers. it is shown that even small amounts of the peptide ... | 2011 | 21447322 |
| [regaining dignity: the experience and process of reconstructing normal defecation functions through an anal sphincter-saving operation]. | resection through an anal sphincter-saving (ass) operation may affect a low rectal cancer patient'snormal defecation function. the long and complex reconstruction process following such a procedure makes understanding the patient rehabilitation experience necessary in order to develop an effective educational strategy that addresses patient needs. | 2011 | 21455890 |
| connectivity of the asiatic wild ass population in the mongolian gobi. | long-distance migrations of wildlife have been identified as important biological phenomena, but their conservation remains a major challenge. the mongolian gobi is one of the last refuges for the asiatic wild ass (equus hemionus) and other threatened migratory mammals. using historic and current distribution ranges, population genetics, and telemetry data we assessed the connectivity of the wild ass population in the context of natural and anthropogenic landscape features and the existing netwo ... | 2011 | 21461051 |
| serological survey of african horse sickness in selected districts of jimma zone, southwestern ethiopia. | a cross-sectional serological survey was undertaken in selected districts of different agro-ecology of jimma zone (dedo, yebu, seka, serbo, and jimma town) from november 2009 to february 2010 to determine the seroprevalence of african horse sickness virus and associated risk factors of the disease. two hundred seventy-four equids (189 horses, 43 mules, and 47 donkeys) with a history of non-vaccination for at least 2 years were selected randomly from the above areas. sera samples were collected a ... | 2011 | 21465102 |
| another look at baseball player initials and longevity. | abel and kruger (2007) reported that major league baseball players whose names have positive initials (such as ace or god) live an average of 13 years longer than do players with negative initials (such as ass or bad) or players with neutral initials (such as ghr or tsw). however, this conclusion is based on a very small sample, selective initials, and a flawed statistical test. there is no statistically significant relationship between initials and longevity for major league baseball players wh ... | 2011 | 21466094 |
| [positive impact of ass on cancer incidence and mortality]. | | 2011 | 21476184 |
| inhibition of staphylococcus aureus cysteine proteases by human serpin potentially limits staphylococcal virulence. | bacterial proteases are considered virulence factors and it is presumed that by abrogating their activity, host endogenous protease inhibitors play a role in host defense against invading pathogens. here we present data showing that staphylococcus aureus cysteine proteases (staphopains) are efficiently inhibited by squamous cell carcinoma antigen 1 (scca1), an epithelial-derived serpin. the high association rate constant (k(ass)) for inhibitory complex formation (1.9×10(4) m/s and 5.8×10(4) m/s ... | 2011 | 21476872 |
| octave spanning supercontinuum in an as₂s₃ taper using ultralow pump pulse energy. | an octave spanning spectrum is generated in an as₂s₃ taper via 77 pj pulses from an ultrafast fiber laser. using a previously developed tapering method, we construct a 1.3 μm taper that has a zero-dispersion wavelength around 1.4 μm. the low two-photon absorption of sulfide-based chalcogenide fiber allows for higher input powers than previous efforts in selenium-based chalcogenide tapered fibers. this higher power handling capability combined with input pulse chirp compensation allows an octave ... | 2011 | 21479003 |
| inhibition of lps toxicity by hepatic argininosuccinate synthase (ass): novel roles for ass in innate immune responses to bacterial infection. | lipopolysaccharide (lps), a structural component of gram-negative bacteria, is implicated in the pathogenesis of endotoxemia/sepsis and multi-organ injury, including liver damage. we have shown that argininosuccinate synthase (ass), a hepatic enzyme of the urea cycle, accumulates in circulation within 1h after treatment with both lps alone and hepatotoxic combination of lps and d-galactosamine. these findings indicate ass as a sensitive biomarker of liver responses to bacterial endotoxin. furthe ... | 2011 | 21481813 |
| death secondary to a donkey's bites. | we present a unique case of death due to the assault and bites of a donkey on a 65-year-old man. the farmer, found dead in his farmyard, had a very deep wound in the anterior region of the neck, with a sharp transection of the trachea and severe bleeding by several minor vessels wall disruptions. the cause of death was established to be massive bleeding combined with asphyxia due to aspiration of the blood. moreover, multiple contusions with associated skin abrasions and perforations were presen ... | 2011 | 21490498 |
| the medicinal use of realgar (as(4)s(4)) and its recent development as an anticancer agent. | arsenicals have been known as poisons and paradoxically as therapeutic agents. in the early 1970s, chinese physicians from harbin revived the medicinal use of arsenicals as anticancer agents. notable success was observed in the treatment of acute promyelocytic leukemia (apl) with arsenic trioxide (ato). the fda approved ato injection in the year 2000 for the treatment of apl. in contrast, the clinical use of the other arsenical, realgar (as(4)s(4)), is currently much less established, though it ... | 2011 | 21497649 |
| detection of antisynthetase syndrome in patients with idiopathic interstitial pneumonias. | objectives: antisynthetase syndrome (ass) is characterized by autoantibodies to aminoacyl-trna synthetases (anti-synthetase) and it is frequently associated with interstitial lung disease. the purpose of this study was to elucidate the prevalence and characteristics of the anti-synthetase positive subpopulation among idiopathic interstitial pneumonias (iips) and to clarify the importance of screening for these antibodies. methods: a retrospective study was performed in 198 consecutive cases with ... | 2011 | 21514811 |
| cognitively preserved subjects with transitional cerebrospinal fluid ß-amyloid 1-42 values have thicker cortex in alzheimer's disease vulnerable areas. | background: establishing the relationship between cerebrospinal fluid (csf) ß-amyloid 1-42 (aß) and cortical thickness (cth) would represent a major step forward in the understanding of the alzheimer's disease (ad) process. we studied this relationship in a group of healthy control subjects and subjects with subjective memory complaints with preserved cognitive function at neuropsychological testing. methods: in this cross-sectional study, 33 individuals (17 healthy control subjects and 16 subje ... | 2011 | 21514924 |