| letter: effects of hypotension on rhesus monkeys. | | 1976 | 816340 |
| [the life cycle of the sarcosporidia. viii. sporocysts of sarcocystis bovihominis in the feces of rhesus monkeys (macaca rhesus) and baboons (papio cynocephalus)]. | | 1976 | 816348 |
| estrogen-induced gonadotropin release in ovariectomized rhesus monkeys and its advancement by progesterone. | | 1975 | 816395 |
| effects of age and season on sexual behavior and plasma testosterone and dihydrotestosterone concentrations of laboratory-housed male rhesus monkeys (macaca mulatta). | | 1975 | 816396 |
| [comparison of the patterns of late thymidine-h3 incorporation with the distribution of g-segments in easily identifiable chromosomes of macaca mulatta monkeys]. | a study was made of reduplication of readily identifyable chromosomes 1, 2, 8 and 9 in the culture of the peripheral blood lymphocytes of macacus mulatta. there proved to be synchronous reduplication of the chromosomes under study at the end of stages s. areas of late-reduplication completely corresponded to the g-segments. | 1975 | 816398 |
| toxicology studies with cytembena (nsc-104801), an antineoplastic agent with a multispecies nephrotoxic effect. | the toxic effects of cytembena in beagle dogs and rhesus monkeys were investigated with the drug given as single or daily iv injections in doses ranging from 12.5 to 200 mg/kg/day to dogs and 6.25 to 50 mg/kg/day to monkeys. renal tubular damage was a major drug- and dose-related finding in both species and was clinically indicated by an accompanying uremia, elevated serum creatinine, and proteinuria. in the kidney, the primary lesion was cellular necrosis and desquamation of the distal tubular ... | 1975 | 816457 |
| the distribution of (14c) cholesterol in muscle and skin of rhesus monkeys after intravenous injection. | 1. the specific radioactivity of [14c]cholesterol in plasma and in serial biopsies of muscle and skin was measured in rhesus monkeys for 156 days after a single intravenous injection of [14c]cholesterol. 2. analysis of the specific radioactitivy-time curves in terms of a two-compartment system indicated that all the cholesterol of muscle is exchangeable with the plasma cholesterol and that local synthesis does not contribute significantly to the cholesterol in muscle. 3. analysis of the curve fo ... | 1976 | 816589 |
| qualities of mother-infant relationships in monkeys. | we habitually use qualitative terms to describe relationships. this paper is concerned with methods for describing, assessing and classifying these qualities objectively. some judgements about qualities depend on which interactions occur, some concern qualities of the interactions themselves, and some depend on the way in which the different interactions within a relationship are patterned. in addition some judgements depend on diverse criteria which are not necessarily correlated with each othe ... | 1975 | 816621 |
| mothers' and infants' roles: distinguishing the questions to be asked. | the mother-infant relationship consists of interaction sequences, each of which is in some measure unique. we must therefore study pooled data from interactions of the same 'type' occurring within a limited time period. changes in the relationship must be assessed by comparing data from different time periods. to understand the dynamics of the interaction, it is essential to formulate sharply the questions being asked. in particular, the following questions must not be confused: 'which partner i ... | 1975 | 816622 |
| recovery of motor function after lesions in motor cortex of monkey. | this behavioural study concerns the contribution of active retraining to motor recovery after a standard lesion in the motor cortex, and includes an evaluation of various retraining procedures. these problems have not previously been experimentally analysed in man or animal. rhesus monkeys (27) were initially trained on two motor tasks which consisted of a pulling task, involving the proximal muscles of the upper limb, and a hand-grip task for the distal musculature. strength of pulling and hand ... | 1975 | 816625 |
| an intra-ovarian site for the luteolytic action of estrogen in the rhesus monkey. | to investigate whether estradiol can act within the ovary to induce luteolysis in the rhesus monkey, 100 mug estradiol-17beta were injected on one of days 2, 3, or 4 after the preovulatory lh peak into one of the following sites: the stroma of the ovary containing the developing corpus luteum, the stroma of the contralateral ovary, or sc. when estradiol was injected into the ovary containing the corpus luteum, the functional life span of the corpus luteum was shortened, reflected by a premature ... | 1976 | 816637 |
| contribution of granulosa cells and follicular fluid to ovarian estrogen secretion in rhesus monkey in vivo. | in order to ascertain which ovarian cell type within the follicle is the source of preovulatory estrogen secretion in vivo, ovarian venous, as well as peripheral venous, blood was collected prior to, 5 min, 30 min, and 120 min after the removal of follicular fluid and granulosa cells from 17 monkeys. in addition, estrogen, progesterone, and progestins were measured in the peripheral blood, ovarian venous blood, and follicular fluid of the follicle-containing and contralateral ovary in 24 monkeys ... | 1976 | 816638 |
| pharmacokinetic properties of ethosuximide in monkeys. i. single-dose intravenous and oral administration. | the pharmacokinetic profile of ethosuximide was studied in 6 chronically catheterized male rhesus monkeys at three dose levels (30, 60, and 90 mg/kg), intravenously and orally. plasma and urine levels were assayed by glc. the intravenous and oral kinetics of ethosuximide were described in terms of a one-compartment open model with first-order elimination (and first-order absorption for oral kinetics). volume of distribution (overall mean +/- sd=0.80 +/- 0.09 liters/kg), total body clearance (ove ... | 1975 | 816644 |
| pharmacokinetic properties of ethosuximide in monkeys. ii. chronic intravenous and oral administration. | three types of chronic-dosing experiments were implemented in a group of chronically catheterized male rhesus monkeys: study i, constant rate infusion; study ii, infusion at three consecutive rates with priming doses; and study iii, oral multiple dosing at two consecutive levels with priming doses. zero-order infusion rates and priming and maintenance doses were calculated for each animal using individual single-dose pharmacokinetic parameters. ethosuximide was measured in plasma and urine by gl ... | 1975 | 816645 |
| ovarian hormones and food intake in female guinea pigs and rhesus monkeys. | | 1975 | 816725 |
| role of plasma filtration in the intestinal fluid secretion mediated by infection with salmonella typhimurium. | the mechanisms whereby invasive enteropathogens, e.g., salmonella typhimurium, induce intestinal secretion are largely unknown. since these organisms penetrate the intestinal epithelium, disrupt the brush border, and evoke an acute inflammatory reaction, increased plasma filtration through a damaged, more permeable epithelium might contribute to the secretory process. to examine this possibility, the plasma-to-lumen clearance of two different sized molecules, [51cr]albumin and [14c]mannitol, was ... | 1976 | 816744 |
| immunologic basis for vaccination against dental caries in rhesus monkeys. | the effects of immunization with streptococcus mutans on the development of caries and the immune responses were investigated in 37 young rhesus monkeys (macaca mulatta) during a period of up to 33 months. the monkeys were supplied a human type of carbohydrate-rich diet that contained about 15% sucrose. the monkeys were separated into seven groups, and the effects of two whole cell vaccines and an extracellular culture extract of s mutans in freund's incomplete adjuvant were compared with a vacc ... | 1976 | 816834 |
| effective immunity to dental caries: studies of active and passive immunity to streptococcus mutans in malnourished rats. | the present studies suggest that rat dams passively transfer igg to their offspring via milk. furthermore, rat dams hyperimmunized to s mutans after intravenous administration of this bacterium have serum-precipitating antibody to s mutans group-specific antigen. this serum precipitin was also observed in serums of their offspring during the suckling period and was detectable for a week after weaning. when these offspring were infected with s mutans on the day of weaning, significantly fewer smo ... | 1976 | 816836 |
| hypertriglyceridemia produced by endotoxin: role of impaired triglyceride disposal mechanisms. | the role of salmonella typhimurium endotoxin in producing hypertriglyceridemia was investigated in 70 male rhesus monkeys. dose-response studies were performed with 0.3-9.0 mg of endotoxin/kg injected intravenously; free fatty acids and triglycerides were measured during the subsequent 8 hr. the effect of endotoxin on lipid disposal mechanisms was assessed by both intravenous lipid-loading tests and total plasma lipolytic activity after administration of heparin. the possible interference of end ... | 1976 | 816977 |
| lateral displacement of the mandible in rhesus monkeys. | lateral displacement of the mandible was induced experimentally in five adult male rhesus monkeys. following from 2 1/2 weeks to 19 months, the animals were sacrificed and examined histologically. two of the monkeys received h3 proline 4 months prior to sacrifice and radioautographs were prepared. the lateral displacement apparently caused great discomfort because the monkeys refused to eat and lost weight rapidly for a few months. after about 12 months, the monkeys could again eat their normal ... | 1976 | 817007 |
| immune response to leishmania tropica in macaca mulatta. | clinical resistance to primary, secondary, and tertiary infections with leishmania tropica, cellular- and humoral-immune responses, and the effects of antilymphocyte globulin (alg) therapy on these parameters were studied in rhesus monkeys. cellular immunity was assessed by in vitro blastoid transformation of lymphocytes in the presence of l. tropica antigen. humoral-immune response was detected by the agglutination of trypsinized organisms. in the monkeys, it was found that (a) immunity did not ... | 1976 | 817009 |
| biochemical changes occurring after blunt chest trauma in monkeys. | anesthetized adult female rhesus monkeys were impacted in the middle of the sternum with a 10 kg stunner traveling at a speed of 22-25 mph to simulate an automobile accident. blodd was obtained at 10 and 60 min following the impact, and approximately 50 values were measured with an autoanalyzer. blunt chest shock and trauma produced a biochemical, hematologic, and urinary profile which might be used to aid life saving measures. | 1976 | 817079 |
| a comparison of several intradermal tuberculins in macaca mulatta during an epizootic of tuberculosis. | during an epizootic of tuberculosis in rhesus monkeys, several intradermal test reagents were compared for accuracy in detecting tuberculosis and for strength of reaction elicited. a purified protein derivative of mycobacterium bovis, similar to one which will probably be approved for official veterinary testing and thus eliminate tuberculin-mammalian intradermic from commercial production, was among those evaluated. none of the reagents was found to be superior to tuberculin-mammalian intraderm ... | 1976 | 817080 |
| effect of bowel resection on lower esophageal high pressure zone and reflux status in rhesus monkeys. | | 1976 | 817085 |
| homovanillic acid transport by the spinal cord. | spinal subarachnoid perfusions of rhesus monkeys were performed to study spinal transport of homovanillic acid in control and probenecid-treated animals. homovanillic acid enters capillaries within spinal tissue throughout the spinal cord. the mean capillary exchange half-time for homovanillic acid was 19.2+/-2.8 minutes; probenecid did not affect this value significantly. despite its polar nature, homovanillic acid crosses cell boundaries easily and equilibrates in a distribution volume (55 per ... | 1976 | 817223 |
| preovulatory granulosa cells and steroidogenesis. an ultrastructural study in the rhesus monkey. | granulosa cells of developing preovulatory follicles from ovaries of 6 rhesus monkeys were studied with the electron microscope. they did not contain the cytoplasmic structures known to be associated with steroidogenesis. such structures were found only in the luteinized granulosa cells of atretic follicles in the preovulatory ovary. the preovulatory granulosa cells were rich in rna, and the production of the liquor folliculi is probably their main function. the apparent contradiction between t ... | 1976 | 817240 |
| mazindol self-administration in the rhesus monkey. | the ability of the intravenous administration of mazindol (sah 42-548) to act as a reinforcer in monkeys previously conditioned to self-administer cocaine was ascertained. unit dosages i.e. dosage per injection, of 50 and 100 mug/kg resulted in self-administration rates significantly greater than that which occurred with saline. an inverse relationship existed between unit dosage and frequency of self-administration over the unit dosage range 50-200 mug/kg. the total mazindol dosage self-adminis ... | 1976 | 817301 |
| effects of dopamine-receptor blockade on self-stimulation in the monkey. | in a dose-response experiment it was shown that intraperitoneal injections of 0.062 mg/kg, and 0.1 mg/kg of the dopamine-receptor blocking agent and neuroleptic spiroperidol severely attenuate self-stimulation in the orbitofrontal cortex, hypothalamus, and in the region of the locus coeruleus, in the rhesus monkey and in the squirrel monkey. in the rhesus monkey intracranial injections of 6 mug of spiroperidol bilaterally into the nucleus accumbens or the hypothalamus attenuated self-stimulation ... | 1976 | 817302 |
| pharmacological and environmental variables affecting drug preference in rhesus monkeys. | | 1975 | 817306 |
| concurrent schedules of cocaine injection in rhesus monkeys: dose variations under independent and non-independent variable-interval procedures. | | 1975 | 817308 |
| naloxone as a negative reinforcer in rhesus monkeys: effects of dose, schedule, and narcotic regimen. | | 1975 | 817310 |
| termination of a schedule complex associated with intravenous injections of nalorphine in morphine-dependent rhesus monkeys. | | 1975 | 817311 |
| chlorpromazine excretion in chronically dosed primates. i. occurrence of a previously unreported class of chlorpromazine conjugates. | the use of tritiated chlorpromazine to correlate total excretion of radioactivity with characterization of the radioactive metabolites had shown a substantial discrepancy. while radioactivity was totally excreted and accounted for within three weeks, recognizable chlorpromazine metabolites represented only about two thirds of the radioactivity in any given sample. to rule out tritium exchange, 14c-labeled chlorpromazine was administered to rhesus monkeys. the same discrepancy was observed, prima ... | 1975 | 817372 |
| in vivo protein synthesis in morphine tolerant monkey brain. | most investigations dealing with brain protein synthesis in opiate tolerant animals have been restricted to rodent species (rat, mouse and rabbit). we now report data obtained from the monkey (macaca mulatta). in vivo incorporation of [u-14c]lysine into acid-precipitable protein of various areas of normal and opiate tolerant primate brain was studied. exposure of the animals to a 1 hour pulse of the radioactive amino acid resulted in no significant difference in the incorporation rate into prote ... | 1975 | 817375 |
| internal fixation of humeral fractures in rhesus monkeys (mucaca mulatta). | | 1976 | 817435 |
| [establishment of standardized clinical-chemistry normal ranges on toxicology, as demonstrated on the example of serum cholesterol in rhesus monkeys and beagle dogs]. | | 1975 | 817534 |
| spinal subarachnoid perfusion of rhesus monkeys. | a technique of spinal subarachnoid perfusion is descirbed which effectively isolates the spinal cord from the remainder of the central nervous system. a method of obtaining and analyzing spinal cord tissue after subarachnoid perfusion is presented. the spinal subarachnoid space of 12 rhesus monkeys was perfused with [14c]sucrose, [14c]ethylenediaminetetraacetic acid-calcium complex (edta), and dextran blue as test substances. the sucrose and edta spinal cord distribution spaces are 13.6 +/- 0.9% ... | 1976 | 817608 |
| feeding behavior in monkeys with and without lesions of the hypothalamus. | in monkeys (macaca mulatta) without hypothalamic lesions, food intake was found to increase with increasing age and body weight; however, food intake per kilogram body weight showed a decline over the same period of time. as the animals became older, the amount of food intake converted to body weight decreased dramatically (feeding efficiency). water intake was shown to be closely coupled to food intake. both daily food and water-intake data were highly reliable over a period of years. monkeys w ... | 1976 | 817609 |
| response of primate heart to emotional stress before and after cardiac denervation. | eleven chair-restrained rhesus monkeys were classically conditioned to a 1-min, 900-hz tone (csf) followed by food and a 1-min, 3.4-5hz tone (css) followed by shock. each conditional stimulus produced large, sudden, and highly significant (p less than .01) increases in left ventricular systolic pressure (lvp), its first time derivative (d(lvp)/dt), and heart rate (hr). the animal's hearts were sugically denervated following control studies of the conditional responses. two to four weeks later, t ... | 1976 | 817612 |
| effects of artificial feeding on aggressive behaviour of rhesus mondeys in india. | artificial feeding of rhesus monkeys (macaca mulatta), which provides the major food source for most rhesus groups in rural and urban habitats, is common practice in india. such feeding results in significant increases in aggressive competition within the monkey groups: during feeding periods the frequencies of aggressive threats, chases, and attacks increased two to six times above those of non-feeding periods in each of eight different groups. fighting behaviour did not increase in most groups ... | 1976 | 817622 |
| technique for portal catheterization in rhesus monkeys (macaca mulatta). | a technique was developed for catheterization of the portal vein in rhesus monkeys (macaca mulatta). silicone rubber catheters (0.040 id by 0.085 inch od, or 0.030 id by 0.065 inch od) were surgically placed into the portal vein via the umbilical, inferior mesenteric, right colic, or ileocolic veins. the right colic and ileocolic veins proved to be the preferred route for catheterization. both single end-hole and multiple end-hole catheters with 2 side holes were used. catheter function was depe ... | 1976 | 817627 |
| primate model for studies of clinical problems of middle ear functions. | eustachian tube and middle ear function has been studied in the acute and chronically prepared rhesus monkey preparation. measures have included observations of tympanometry and input impedance of the middle ear, of transmission of energy through the middle ear, of static middle ear pressure and of threshold and suprathreshold hearing. positive and negative long and short-term static middle ear pressures, the effects of middle ear fluids, and various aspects of eustachian tube function in both n ... | 1976 | 817637 |
| the metabolism of (14c)nicotine by isolated rhesus monkey hepatocytes in vitro. | | 1976 | 817725 |
| prophylaxis with diphenylhydantoin and phenobarbital and alumina-gel monkey model. i. twelve months of treatment: seizure, eeg, blood, and behavioral data. | utilizing an alumina-gel epileptic monkey model, with instrumentation for continuous monitoring of all overt, spontaneous motor seizures, the efficacy of pharmacologic prophylactic treatment of posttraumatic epilepsy was explored. the alumina-gel model provides a relatively standardized brain trauma from monkey to monkey, resulting in virtually complete assurance that all animals will manifest, in time, electrical and clinical seizures if not treated. thirteen rhesus monkeys were divided into tw ... | 1976 | 817891 |
| ultradian rhythms in the mobility and behavior of rhesus monkeys. | the presence of ultradian rhythms in the mobility and behavior of rhesus monkeys was explored in eleven animals equipped with mobility fm transmitters and placed alone or in pairs in laboratory cage situated in a sound proof, temperature controlled room, with food and water ad libitum. after an habituation period of 3 to 7 days, telemetric recordings of the mobility of the animals showed ultradian rhythms with a periodicity of 70 min during the daily 12-h light period. during the corresponding 1 ... | 1976 | 817921 |
| behavioral and hormonal effects of attachment object separation in surrogate-peer-reared and mother-reared infant rhesus monkeys. | mother-reared and surrogate-peer-reared rhesus monkeys were separated from their respective attachment objects at 6 months of age and tested for the following 9 weeks to determine their home-cage behavior and their pituitary-adrenocortical responses to stress. both groups displayed a strong immediate behavioral response to separation which was characterized by increased vocalization, increased locomotion, and decreased self-play. however, the surrogate-peer-reared infants showed a subsequent rec ... | 1975 | 817950 |
| impaired lithocholate sulfation in the rhesus monkey: a possible mechanism for chenodeoxycholate toxicity. | radioactive lithocholate was administered intravenously to female rhesus monkeys with an exteriorized enterohepatic circulation, and the chemical form of biliary radioactivity was defined by thin layer chromatography. most radioactivity was excreted in bile in the form of unsulfated conjugates (77%), indicating impaired sulfation relative to published data for man. defective sulfation of lithocholate, the major bacterial biotransformation product of chenodeoxycholic acid, can explain accumulatio ... | 1976 | 817960 |
| reproductive dysfunction in rhesus monkeys exposed to low levels of polychlorinated biphenyls (aoroclor 1248). | | 1976 | 817997 |
| antiarrhythmic activity of racemic propranolol and its optical isomers in ouabain-induced cardiac arrhythmias in rhesus monkeys. | | 1975 | 818008 |
| postnatal maturation of subcortical projections from the prefrontal cortex in the rhesus monkey. | orbital and dorsolateral prefrontal lesions were performed on a series of rhesus monkeys at 2, 6, or 24 months of age. the consequent degeneration in the efferent pathways from these cortical regions to the caudate nucleus, the dorsomedial nucleus of the thalamus and adjacent structures was studied at 5- and 15-day survival times by a modification of the nauta-gygax method for tracing degenerating fibers. following dorsolateral lesions, considerable numbers of black-impregnated degenerating fibe ... | 1976 | 818131 |
| tomographic images of blood pool and perfusion in brain and heart. | a whole-body positron-emission transaxial tomograph (pett iii) was used to image the cross-sectional distribution of 13nh3 and 11co-hemoglobin in the human brain and heart. carotid and intravenous bolus injections of 13nh3 in the rhesus monkey had shown that 13nh3 is efficiently extracted by the brain and clears from it slowly (half-time, 40-50 min for carotid injections and 60-70 min for intravenous injections). the intravenous tomographic images in humans showed an excellent relationship betwe ... | 1976 | 818345 |
| histopathologic evaluation of the effects of four calcium hydroxide liners on monkey pulps. | pulpal response of four calcium hydroxide liners, mpc 10, mpc 12, dycal and pulpdent were tested on primary and permanent teeth with zinc oxide and eugenol (zoe) and silicate as controls. responses of the pulps were evaluatedi in rhesus monkeys, utilizing class v cavity preparations at 3 days, 5 and 8 weeks. an equivalent number of anterior and posterior teeth were studied for all compounds. the ca(oh)2 liners, zinc oxide and eugenol (zoe) and silicate controls were placed in 80 primary and 80 p ... | 1976 | 818349 |
| allogeneic iliac transplants in rhesus monkeys. a sequential histologic study. | fresh and frozen allogeneic iliac grafts were used in surgically prepared intraosseous defects. four adult rhesus monkeys provided 19 specimens from 0 to 56 days postoperative. there were 8 specimens for each type of graft and 3 others used as controls. histologic sections from each specimen were prepared and a description of the sequential healing events was given. the similarities and differences in repair were discussed. the advantages and disadvantages of each technique were analyzed and ins ... | 1976 | 818360 |
| xenogeneic implants in primates. collagen and chondroitin sulfate. | this study was undertaken to examine histologically, in monkeys, the sequential healing phenomena of created two-walled osseous defects, which have been corrected by purified collagen and a mixed isomer of chondroitin sulfate. four adult rhesus monkeys were used as experimental models and provided 23 specimens, from 0 to 56 days postoperatively. sixteen of these served as implant specimens, and seven served as control specimens in which defects were corrected by curettage only. two types of impl ... | 1976 | 818361 |
| a possible mechanism of ellipticine-induced hemolysis. | ellipticine (e) [5,11-dimethyl-6h-pyrido-(4,3-b)-carbazole, nsc-71795] is an antineoplastic agent which is active against l1210 lymphocytic leukemia in mice. preclinical toxicologic studies demonstrated hemolysis in dogs and monkeys following intravenous administration of 1.5 mg/kg. this finding prompted this investigation of the mechanism of hemolysis and a study of the various factors that might ameliorate this effect. initial experiments demonstrated that human red blood cells were completely ... | 1976 | 818364 |
| mating in the rhesus monkey (macaca mulatta) after conception and its relationship to oestradiol and progesterone levels throughout pregnancy. | behavioural and hormonal data were collected throughout pregnancy in captive rhesus monkeys. heterosexual pairs observed in daily time-limited mating tests showed two distinct periods of increased sexual interaction, as measured by the incidence of ejaculation. one period was coincident with the preovulatory oestradiol peak, while the other occurred between the 6th and 10th weeks of pregnancy. the positive relationship found during the menstrual cycle between the ratio of circulating oestradiol: ... | 1976 | 818372 |
| paternity and status in a rhesus monkey group. | in the blood from 63 rhesus monkeys (macaca mulatta), transferrin, 6-phosphogluconate dehydrogenase, carbonic anhydrase ii, phosphohexose isomerase, nadh diaphorase and leucocyte antigens were polymorphic. on the basis of these traits, paternity eliminations were determined for 29 offspring of 26 females from an established breeding group containing 8 sexually mature males. the dominance of the males was assessed by the directionality of the agonistic encounters. after examination of the results ... | 1976 | 818374 |
| experimental lead paint poisoning in nonhuman primates. i. clinical signs and course. | lead-containing paints were administered orally to 27 rhesus monkeys for periods of 18-667 days. lead acetate was fed to nine monkeys of three different species for 9-156 days. excretion of one week's dose of lead in six primates ranged from 35 to 94%. the animals incurred moderate to extreme elevations of lead in blood, most lost weight, or had depressed weight gains, and developed burtonian lines, some died suddenly and unexpectedly, and many terminated in a moribund state with profound anemia ... | 1976 | 818384 |
| estimation of fetal age and weight from radiographic skull diameters in the rhesus monkey (macaca mulatta). | in utero radiographic measurements of the skull of a rhesus monkey fetus provide estimates of conceptual age and body weight with about a 6% and 15% error of estimate, respectively. | 1976 | 818386 |
| hypospadias in a male rhesus monkey. | mid-shaft penile hypospadias was found in an otherwise normal adult male rhesus monkey. histological examination of the penis supports the conclusion that the condition was congenital and not due to trauma. | 1976 | 818389 |
| a chronic implant for intracerebral mass spectrometric gasometry in the rhesus monkey. | a cranial implant was developed to facilitate mass spectrometric gasometry in cerebral tissue of conscious primates. it is permanently fixed to the skull and allows repeated introduction of a teflon diffusion membrane into the cerebrum. the implant is simple to manufacture and mount. it has been tolerated well with repeated introduction of the catheter for more than 6 mo in 10 rhesus monkeys. the preparation avoids the complication and artifacts of an acute surgical preparation for investigation ... | 1976 | 818447 |
| picture memory (pseudomatching) in rhesus monkeys. | pseudomatching, the selection of the correct comparison stimulus without dependence on presentation of a sample stimulus, was demonstrated in monkeys being trained ostensibly on a matching-to-sample, shock-avoidance tast. pseudomatiching occurred whenever the problem sets were not fully counterbalanced for key position and correct symbol and seemed to represent memorization of specific stimulus configurations. some animals showed the capacity to memorize hundreds of different 4-choice problems a ... | 1976 | 818612 |
| training and performance of rhesus monkeys as operators in a compensatory manual control system. | two rhesus monkeys were trained as operators in a compensatory manual control system similar to systems used in human studies. training procedures used to shape compensatory tracking behavior included a multiple shock-avoidance technique, the gradual introduction of the system input, and sharpening visual stimulus control of tracking behavior. time-on-target scores for the monkeys were 95% to 98% while responding to three different frequency bandwidths of the system input. as frequency bandwidth ... | 1976 | 818613 |
| cross-modal matching and the primate frontal cortex. | rhesus monkeys with selective lesions of the prefrontal system were tested on a tactile-visual cross-modal matching task. monkeys with lesions in the banks and depths of the arcuate sulcus were impaired, while normal controls and monkeys with lesions in the banks and depths of the sulcus principalis and in the anterodorsal part of the head of the caudate nucleus were not. | 1976 | 818708 |
| experimental infection of ancylostoma ceylanicum in rhesus monkeys. | | 1975 | 818719 |
| in vitro evaluation of corpus luteum function of cycling and pregnant rhesus monkeys: progesterone production by dispersed luteal cells. | corpus luteum function in the cycling and the pregnant rhesus monkey (macaca mulatta) was evaluated through short term in vitro studies of progesterone production by suspensions of collagenase-dispersed luteal cells in the presence and absence of exogenous gonadotropin (human chorionic gonadotropin, hcg). cells from mid-luteal phase of the menstrual cycle secreted progesterone, as measured by accumulation of this hormone in the incubation medium, and responded to the addition of 100 ng hcg/ml wi ... | 1976 | 818745 |
| [further study of the pathological process induced in monkeys by lpv oncornavirus]. | experiments were performed on pathogenicity of lpv oncornavirus and mason-pfizer-like virus for monkeys macaca mulatta. the mixture of culture fluid and cell homogenate ultrafiltrates of virus-producing t-9 cell line was used as a source of lpv virus. the same materials derived from hep-2 continuous cell line served as a source of mason-pfizer-like virus. as a control monkeys were inoculated with ultrafiltrates from human diploid cells. the clinical and pathomorphological analysis of experimenta ... | 1975 | 818816 |
| [the effect of electrostimulation of the premotor cortex and hippocampus on delayed choice in monkeys]. | the influence of electrical stimulation of the prefrontal cortex and the hippocampus on solving the problem of delayed spatial choice was studied on four rhesus macaques. stimulation was carried out by rectangular pulses of different amplitude in the first and last two seconds of delay (lasting from five to six seconds). a statistically significant increase of errors was found during the stimulation: 1) of the structures of the left hemisphere (the effect was averaged in relation to the moment o ... | 1976 | 818843 |
| the effects of control over high intensity noise on plasma cortisol levels in rhesus monkeys. | | 1976 | 818996 |
| diazepam in the prophylaxis of lignocaine seizures. | diazepam 0.05-0.25 mg/kg increased the dose of lignocaine required to cause seizures in rhesus monkeys by 24-34%. spontaneous ventilation was maintained adequately during lignocaine administration following diazepam treatment and no adverse cardiovascular effects occurred. before the onset of lignocaine-induced seizures in non-treated animals, the animals appeared to be drowsy. however, prior to administration of diazepam masked this effect. convulsions were controlled by smaller doses of diazep ... | 1976 | 819022 |
| induction of ovulation in premenarchial rhesus monkeys with human gonadotropins. | | 1976 | 819046 |
| cyclic and diurnal patterns of serum prolactin in the rhesus monkey. | | 1976 | 819048 |
| the fine structure of corpus luteum from intact, hypophysectomized and fetectomized pregnant monkeys (macaca mulatta) at term. | | 1976 | 819051 |
| [ganglionic cytoarchitecture of the esophagus in the cat and the rhesus monkey]. | the comparative study of neuron distribution in the myenteric and submucous plexuses has granted an appraisal of the various neuron types in the oesophagus ganglia of cat and rhesus monkey. neurons are classified in dogiel types i and ii, plus an intermediate one, the so-called "type iii". from the functional point of view, the hypothesis is established that these types are, respectively: efferent, afferent and associative. a confirmation of this hypothesis requires the endorsement of the result ... | 1975 | 819065 |
| the cortical projections of the inferior pulvinar and adjacent lateral pulvinar in the rhesus monkey (macaca mulatta): an autoradiographic study. | an autoradiographic technique was used to determine superior colliculus (sc) and pulvinar projections in the rhesus monkey. sc projects bilaterally to the inferior pulvinar (pi) while occipital cortex projects to pi and the lateral pulvinar (pl). pi has sustaining, topographical projections to layers iv, iii and i of areas 18 and 19 (and vi and i of 17) which agrees with the central representation of the visual hemifield and suggests that there is more than one hemifield representation in prestr ... | 1976 | 819095 |
| acetylcholinesterase-rich projections from the basal forebrain of the rhesus monkey to neocortex. | | 1976 | 819100 |
| temporal cortical projections to the olfactory tubercle in the rhesus monkey. | | 1976 | 819101 |
| electrophysiology of the frontal granular cortex. iii. the cingulate-prefrontal relation in primate. | an investigation of the nature of laminar potentials and impulse discharges of units of dorsolateral prefrontal cortex (fc) evoked by stimulations of cingulate gyrus was made in rhesus monkey. anterior cingulate stimulations evoked 1.0--1.5 msec latency waves, positive on pial surface and negative at fc depths of about 500--2000 mum with about the same time scale. following the positive wave there was also a negative wave response. the amplitude and duration of the surface positive wave and nega ... | 1976 | 819103 |
| responses of primate locus coeruleus and subcoeruleus neurons to stimulation at reinforcing brain sites and to natural reinforcers. | in alert rhesus monkeys the activity of 64-neurons was recorded in the locus coeruleus and subcoeruleus region, collectively referred to as coeruleus (c) neurons. c neurons were identified physiologically by antidromic activation from electrodes in the medial forebrain bundle (mfb) and medial septal nucleus which sustained intracranial self-stimulation (icss) behavior, and/or anatomically by their proximity to microlesions at unit recording sites. the following results were obtained: (1) the cur ... | 1976 | 819104 |
| thalamic projections of the dorsomedial prefrontal cortex in the rhesus monkey (macaca mulatta). | cortical aspirations were made of the dorsomedial prefrontal sector in the rhesus monkey and the resultant anterograde and retrograde degeneration plotted. retrograde changes were mapped using both cresyl violet and modified fink-heimer techniques. following large dorsomedial lesions, small numbers of degenerating fibers were traced through the medial part of the magnocellular ventral anterior nucleus (vamc) and the ventral part of the internal medullary lamina surrounding the anterior nuclei. d ... | 1976 | 819108 |
| giant nerve fibers in the ciliary muscle and iris sphincter of macaca mulatta. | unusually large nerve processes, containing numerous mitochondria, glycogen particles, and synaptic vesicles are described in both the ciliary muscle and the iris sphincter muscle of the rhesus monkey. the striking similarity of these axonal profiles to the dendritic enlargements observed by sotelo and palay (1968) is noted and the possibility that they represent growing ends of peripheral nerve fibers is suggested. | 1976 | 819139 |
| the effect of various dosages of lynestrenol on the plasma levels of oestrogens and progesterone during the menstrual cycle in the rhesus monkey. | | 1976 | 819211 |
| the effects of ovariectomy, estrogen replacement, and neuraminidase treatment on the properties of the adenohypophysial glycoprotein hormones of the rhesus monkey. | a comparison of pituitary extracts from intact and ovariectomized monkeys revealed that, like fsh, lh from ovariectomized animals is larger in average apparent molecular size and disappears from the circulation of test rats less rapidly than does lh from intact females. in contrast, ovariectomy had no effect on the apparent molecular size of tsh nor on its disappearance rate following injection into test rats. reversal of the effect of ovariectomy on the molecular size of both lh and fsh was ach ... | 1976 | 819246 |
| qualitative changes in the pituitary gonadotropins of the male rhesus monkey following castration. | characterization of pituitary lh and fsh from intact and castrated male monkeys showed that gonadotropins from intact males are smaller in average apparent molecular size, and disappear from the circulation of test rats more rapidly than hormones from castrated males. furthermore, intact male monkey lh and fsh are smaller and are cleared from the rat circulation faster than the gonadotropins from intact female monkeys. we conclude that 1) in the rhesus monkey changes in the properties of pituita ... | 1976 | 819247 |
| radioimmunoassay of arginine vasopressin in rhesus monkey plasma. | using a new antiserum, an enzymatic radioiodination of arginine vasopressin (avp), and the methodology of robertson et al. (1,2), we have developed a sensitive and specific radioimmunoassay for plasma avp in the monkey. the sensitivity of the assay is 0.5 muu/ml, the cross reaction with oxytocin (ot), minimal. we used this assay to study the effects that variations in blood osmolality have in regulating avp secretion in unanesthetized, chair-restrained, chamber-isolated, adult female rhesus monk ... | 1976 | 819249 |
| immunocytochemical evidence that luteinizing hormone (lh) and follicle stimulating hormone (fsh) are present in the same cell type in the rhesus monkey pituitary gland. | antisera to olhbeta subunits were used to identify the gonadotrophic cells in partes distalis and tuberalis of the rhesus monkey pituitary gland. the same cell type in pituitary glands obtained from male and female rhesus monkeys stained with both antisera. immunocytochemical staining was observed in pas positive cells that were randomly dispersed throughout the entire pars distalis. the gonadotrophs did not react with antisera to either htshbeta or oacth. these observations indicate that only o ... | 1976 | 819253 |
| characteristics of the output from the dentate nucleus to spinal neurons via pathways which do not involve the primary sensorimotor cortex. | experiments were performed to determine the action of the dentate output on neurons in the spinal cord mediated by pathways which do not involve the primary sensorimotor and premotor cortices. the dentate nucleus was electrically stimulated by stereotaxically placed electrodes in rhesus monkeys whose contralateral sensorimotor and premotor cortices were ablated. the resultant changes in excitability of lumbar alpha motorneurons activated by ia afferents from nerves innervating femoral, hamstring ... | 1976 | 819285 |
| dietary disaccharides in experimental atherosclerosis in rhesus monkeys. | | 1976 | 819292 |
| effects of indomethacin on corpus luteum function and pregnancy in rhesus monkeys. | indomethacin was administered during the luteal phase of the menstrual cycle and during late pregnancy in rhesus monkeys. the plasma indomethacin concentrations achieved were within the ranges effective in inhibiting the microsomal prostaglandin synthetase, even when allowances were made for 90% binding to plasma proteins. there were no significant differences in duration of the luteal phase of menses or in luteal phase progesterone concentrations with indomethacin treatment. our findings do not ... | 1976 | 819311 |
| lack of effect of vaginal lavages and aliphatic acids on ejaculatory responses in rhesus monkeys: behavioral and chemical analyses. | | 1976 | 819344 |
| serum glucosyltransferase-inhibiting antibodies and dental caries in rhesus monkeys immunized against streptococcus mutans. | serum antibodies to glucosyltransferase (gtf) of streptococcus mutans serotype c were assayed sequentially by means of an enzyme inhibition radio-assay in twenty-six rhesus monkeys immunized with s. mutans. pre-immune and control sera had a gtp-enhancing effect which was shown also by albumin and non-immune immunoglobulin fractions. gtf-inhibitory activity was found in igg fractions from some immune sera and could be absorbed by s. mutans cells possessing cell-bound gtf. inhibitory antibodies to ... | 1976 | 819360 |
| lymphocyte surface igd and igm in non-human primates. | igd was detected on the surface of peripheral blood lymphocytes of five non-human primate species by direct immunofluorescence. the percentages of lymphocytes with surface igd or igm were comparable to the percentages reported for humans. the presence of igd on the surface of rhesus monkey lymphocytes was confirmed by sds-polyacrylamide gel electrophoresis of immunoprecipitated 125i cell surface protein. reduced surface igd was resolved into a light chain component and a heavy chain component wh ... | 1976 | 819380 |
| a method to obtain infusion schedules for prescribed blood concentration time courses. | it is sometimes desirable to obtain a specified blood level which obeys a prescribed mathematical form. following an approach based on impulse analysis via laplace transform techniques, a general method for an input injection schedule which will achieve this goal is derived. specific infusion schedules are given which attain blood levels that are constant, increase linearly, decay exponentially, and increase exponentially. further, simpler approximate infusion schedules are also derived whose ou ... | 1976 | 819414 |
| sweating responses during changes of hypothalamic temperature in the rhesus monkey. | a technique is presented for preparing a durable thermode implant in the hypothalamus of the rhesus monkey. in unanesthetized monkeys implanted with thermodes in the anterior hypothalamic area of the brain, a linear relation was found between local sweat rates on the general body surface and clamped hypothalamic temperature. changes in skin temperature were found to shift the hypothalamic set-point temperature at which sweating began but did not alter the gain of the hypothalamic temperature-swe ... | 1976 | 819416 |
| afferent fibers in the substantia gelatinosa of the adult monkey (macaca mulatta): a golgi study. | in horizontally and sagittally sectioned golgi preparations of the adult monkey spinal cord the afferent fibers in the substantia gelatinosa (laminae ii and iii of rexed, '52) were studied with the hope of finding clues that would make it possible to correlate them with the afferent fibers that ramón y cajal ('09) traced from the white matter into the substantia gelatinosa in golgi preparations of the newborn cat. throughout the substantia gelatinosa there are fibers with fine terminal branches, ... | 1976 | 819467 |
| the basilar pontine gray in the adult monkey (macaca mulatta): a golgi study. | in golgi preparations of the adult monkey (macaca mulatta) two types of neurons are distinguished in the pontine gray: (1) larger neurons which impregnate most frequently and (2) smaller neurons which impregnate rarely. the former are judged to be projection neurons with myelinated axons because only the initial segments of their axons impregnate, while the latter are judged to be intrinsic neurons since they appear to participate only in the local circuitry of the pontine gray. the projection n ... | 1976 | 819468 |
| the neurons in the centromedian-parafascicular complex of the monkey (macaca mulatta): a golgi study. | the neurons of the nucleus centrum medianum and the neurons of the nucleus parafascicularis were studied in golgi preparations of the adult monkey (macaca mulatta). the cell bodies of the prinicipal neurons in the nucleus centrum medianum have a few somatic spines and vary in shape: some are cubical with protruding angles; some are egg-shaped; some are elongated and sausage-shaped. four to six slightly branched dendrites of unequal thickness radiate from the cell body. some dendrites extend for ... | 1976 | 819469 |
| the supraoptic nucleus and the supraopticohypophysial tract in the monkey (macaca mulatta). | the observations here on golgi material are based on the study of fortunate impregnations in one horizontally sectioned and one frontally sectioned series found in the collection of golgi preparations of the adult monkey brains (macaca mulatta) available in this laboratory. the soma of the large supraoptic neurons have jagged protrusions and irregular crevices which give their surfaces a craggy appearance. also they have a few somatic spines. their dendrites, which usually arise from two or thre ... | 1976 | 819470 |
| the neurons in the primate subthalamic nucleus: a golgi and electron microscopic study. | in golgi preparations of the adult monkey (macaca mulatta) local interneurons and two varieties of principal neurons, radiating and elongated fusiform, are found in the subthalamic nucleus. the cell bodies of the radiating neurons have a few delicate, somatic spines some of which are occasionally bilobed and trilobed. five to eight dendritic trunks give rise to branching, tapering dendrites, which may extend for over 400 microns. these dendrites are much thinner than the dendrites in the globus ... | 1976 | 819471 |
| cytolytic, complement-dependent antibodies to measles virus in rhesus monkeys after administration of live or killed virus. | infection of rhesus monkeys with measles virus induced specific complement-dependent cytolytic antibodies during the early phase of acute infection. the development of maximal levels of the complement-dependent cytolytic antibodies appears to be dependent on the respiratory rather than the parenteral route of infection and on the use of live rather than killed measles virus. these levels of cytolytic antibodies seem to be independent of levels of simultaneously developing neutralizing and hemagg ... | 1976 | 819595 |