| bacteremia at boston city hospital: occurrence and mortality during 12 selected years (1935-1972), with special reference to hospital-acquired cases. | the cases of all patients hospitalized at boston city hospital during 1972 who had blood cultures positive for a clinically significant, aerobic bacterial pathogen or for candida were analyzed with respect to incidence and mortality, sex, age, admission to medical or surgical services, and the causative organism. similar data were obtained for 11 years between 1935 and 1969 selected to reflect the introduction and general use of various effective antibacterial agents. comparisons were also made ... | 1975 | 1159333 |
| colonization by enterobacteriaceae of the respiratory tract of children with cystic fibrosis of the pancreas and their antibody response. | of 72 patients with fibrosis, 49 harbored enterobacteriaceae in the respiratory tract, including escherichia coli, klebsiella, and enterobacter. colonization by two to four genera was documented in 29 subjects. staphylococcus aureus was recovered from 44 of these 49 patients. the distribution of serogroups of e. coli was similar to that seen in patients with urinary tract infection. antibody response against the o antigens of the patients' own enterobacteriaceae was documented in 29 of these 49 ... | 1975 | 1159579 |
| mediastinitis in a child caused by perforation of pharynx. | mediastinitis in infants and children secondary to trauma is rarely reported as evidenced by a literature search. a case of mediastinitis occurred following perforation of the pharynx by a pencil. in neonates, traumatic perforation may mimic esophageal atresia. in older children with a history of trauma to the mouth or pharynx by a sharp object, the possibility of secondary mediastinitis exists. | 1975 | 1163510 |
| the place of antibiotic prophylaxis in medicine. | | 1975 | 1165230 |
| letter: a 2-hour plate assay for gentamicin. | | 1975 | 1165234 |
| bacterial endocarditis 1963 to 1973. observations on incidence, course and treatment at minneapolis veterans administration hospital. | | 1975 | 1165756 |
| structural studies of the klebsiella type 57 capsular polysaccharide. | the structure of the capsular polysaccharide from klebsiella type 57 has been investigated. methylation analysis, uronic acid degradation, modified smith degradation and graded acid hydrolysis were the principle methods used. pure oligomeric fragments were isolated using the three methods of degradation and characterized by chemical and physical methods. these studies show the structure to consist of a tetrasaccharide repeating unit (all sugar residues have the d-configuration and are pyranosidi ... | 1975 | 1166725 |
| in vitro evaluation of bl-s640, a new oral cephalosporin antibiotic. | bl-s640, a new oral cephalosporin analogue, was evaluated in vitro against 102 gram-negative and 80 gram-positive bacteria. the antimicrobial spectrum was similar to that of previous cephalosporin analogues. good antimicrobial activity against strains of escherichia coli, klebsiella, staphylococci, and streptococci was demonstrated. relatively poor activity and/or resistance was noted among most strains of proteus, providencia, pseudomonas, and serratia. in comparative studies bl-s640 had better ... | 1975 | 1167042 |
| maduromycosis of the brain. case report. | a rare case of a gas-containing brain abscess due to verified maduromycosis is described. blackish material over the abscess cavity revealed the fungal elements. the pus from the abscess contained streptococcus hemolyticus and klebsiella organisms. | 1975 | 1167580 |
| antimicrobial activities of 81.723 hfu, a new pleuromutilin derivative. | the new pleuromutilin derivative 81.723 hfu is extremely active against gram-positive organisms such as streptococci, staphylococci, and against mycoplasmas. a number of shigella, klebsiella, and escherichia coli strains were also found to be quite susceptible to this new agent, whereas other gram-negative organisms like pseudomonas aeruginosa, proteus species, and alcaligenes faecalis proved to be naturally resistant to 81.723 hfu. the new compound acts bacteriostatically. bactericidal effects ... | 1975 | 1170807 |
| agranulocytosis associated with gentamicin. | | 1975 | 1173620 |
| use of bile-esculin agar for rapid differentiation of enterobacteriaceae. | bile-esculin agar has been used for several years for the presumptive identification of group d streptococci. all members of the enterobacteriaceae family will also grow on this medium, but only certain ones can hydrolyze esculin to 6,7-dihydroxycoumarin, which reacts with iron to produce a characteristic blackening of the medium. one thousand and six cultures from clinical specimens representing 20 genera were isolated and identified. heavy inocula from fresh pure culture isolates on heart infu ... | 1975 | 1176613 |
| [biochemical behavior and sensitivity to antibiotics of klebsiella pathogens, isolated from horse test material]. | | 1975 | 1182015 |
| new mechanisms for the biosynthesis and metabolism of 2-keto-l-gulonic acid in bacteria. | l-sorbose is oxidized to 2-keto-l-gulonic acid (kga) via the following sequence of reactions which we call the "sorbosone pathway": l-sorbose in equilibrium l-sorbosone leads to kga. the first step is reversible and is mediated by enzymes found in a soluble fraction obtained from pseudomonas putida atcc 21812. although no cofactor requirements were found for the forward reaction, the reverse reaction clearly required nadh. enzymes for this nadh-dependent synthesis of l-sorbose could be different ... | 1975 | 1182275 |
| amplification of cell-associated immunological memory by secondary antigenic stimulus. secondary type increase in memory. | in mice primed with a mixture of bovine serum albumin (bsa) and adjuvant (capsular polysaccharide of klebsiella pneumoniae (cps-k)) cell-associated immunological memory was increased secondarily after a second injection of bsa alone, whereas a primary injection of bsa alone into normal unprimed mice did not result in detectable memory. the optimum antigen doses for expression of the primary and secondary memories of adoptively transferred cells from unboosted primed donors or boosted donors in i ... | 1975 | 1184116 |
| humoral immunity to gram-negative bacillary infections in experimental animals and man. | | 1975 | 1184193 |
| infection in war wounds: experience during the 1973 october war in israel. | the development of infections in 420 wounded soldiers, admitted to the hadassah university hospital in jerusalem between october 7, 1973 and november 31, 1973, was studied. an attempt was made to relate the development of infection to the type of injury. the overall infection rate was 22%, but varied with the type of injury. three "risk factors" were found to be associated with infection regardless of the number of injuries: 1)penetrating abdominal wounds involving the colon; 2) fractures involv ... | 1975 | 1190879 |
| [the local treatment of ozaena with streptomycin and novocaine (author's transl)]. | the essence of this treatment is the injection of a mixture of 250 mgm of streptomycin (5 ml) and novocaine 1% (5 ml) on alternate days. the 10 ml mixture was injected into the conchae and submucosally into the septum on either side. cure generally required a total of 2--3 gm of streptomycin over 15--20 days. review of 25 cases treated over the past 15 years showed that 44% became symptom free and "good" results occurred in another 40%. in 16% treatment proved ineffective. rehabilation was manif ... | 1975 | 1194101 |
| relationship of indole production and antibiotic susceptibility in the klebsiella bacillus. | of 2,442 klebsiella strains isolated from clinical specimens at the university of minnesota hospitals, 18.3% were found to be indole positive. a randomly selected equal number of indole-positive and indole-negative control isolates, characterized by 27 biochemical tests and by serotyping against 72 antisera, were tested against 14 antibiotics. the results indicated a greater incidence of multiple drug resistance among the indole-negative strains among those that produced indole. the organisms in ... | 1975 | 1194407 |
| four hour-test for the identification of enterobacteriaceae. | a set of 12 rapid biochemical tests--lysinedecarboxylase, ornithinedecarboxylase, beta-galactosidase, urease, hydrogensulphide, indole, acetoin, deoxyribonuclease, esculin, mannitol, raffinose and sorbitol--were selected from an original set of 13 tests and were found to give 98% accurate reactions within 4 hrs of incubation for the identification of bacteria belonging to enterobacteriaceae. this set permits identification on the genus and/or species level for escherichia, shigella, citrobacter, ... | 1975 | 1196260 |
| investigations on the efficacy of surface disinfection and surface cleaning procedures. 1. tests under real-life conditions. | the suitability of disinfection preparations is assessed on the basis of laboratory tests, different methods being used in the various countries. since such model tests are rather inadequate when it comes to judging surface disinfectants, additional in-use tests are desirable. they might, in any case, serve as a reference system for judging the evaluation criteria which still differ widely at the moment. the experiments described in this study were chiefly designed to establish the effect of cle ... | 1975 | 1199525 |
| [studies on the infestation of the equine genital and nasal mucosa especially of stallions, with bacterial pathogens significant in horse breeding, with special reference to klebsiella. 1. epidemiologic studies]. | | 1975 | 1200967 |
| [studies on the infestation of the equine genital and nasal mucosa, especially in stallions, with significant in horse breeding bacterial infective pathogens, with special reference to klebsiella. 1. epidemiologic studies]. | | 1975 | 1200968 |
| splenectomy in homozygous beta thalassaemia: a retrospective study of 30 patients. | in order to clarify the indications for splenectomy in patients with homozygous beta thalassaemia we studied, retrospectively, the basal pre-transfusion haemoglobin levels and blood transfusion requirements before and after splenectomy, in a series of patients with this disorder. thirty-six patients, of whom 20 underwent splenectomy, were included in this study. three groups of patients with homozygous beta thalassaemia were identified on the basis of clinical and laboratory findings. two of the ... | 1975 | 1201250 |
| the early management of open joint injuries. a prospective study of one hundred and forty patients. | a study of open joint injuries treated at the los angeles county-university of southern california medical center from july 1969 through july 1973 showed that the vast majority of these injuries were at the knee. three types of injury were identified: those associated with fractures, injuries without fracture, and gunshot wounds. all patients were treated with antibiotics, surgical débridement and irrigation, and installation of polyethylene tubes into the joint as a system of postoperative clo ... | 1975 | 1201988 |
| [inoculation frequency and microbial characteristics of bacteria of the genus klebsiella from adults and children with different gastrointestinal disease]. | | 1975 | 1207520 |
| in vitro activity and pharmacokinetics in patients of cefamandole, a new cephalsoporin antibiotic. | cefamandole nafate, a new cephalosporin for parenteral use, was evaluated in vitro against 231 recent clinical isolates and in 12 patients. cefamandole had activity equivalent to cefazolin against staphylococcus aureus, escherichia coli, and klebsiella pneumoniae. cefamandole was more active than cephalothin or cefazolin against proteus mirabilis. both cefamandole and cefazolin were as active as cephalothin against s. aureus, were slightly more active against k. pneumoniae, and were considerably ... | 1975 | 1211920 |
| comparison of the antibacterial activities of sisomicin and gentamicin against gram-negative bacteria. | sisomicin was found to be more active on a weight basis than gentamicin against pseudomonas sp., klebsiella sp., and indole-positive proteus. gentamicin was more active than sisomicin against escherichia coli, serratia sp., enterobacter sp., and proteus mirabilis. both antibiotics were very active against methicillin-resistant strains of staphylococcus aureus. | 1975 | 1211927 |
| [lysogeny of klebsiella strains isolated from human infections]. | | 1975 | 1212081 |
| [epidemiology and clinical aspects of klebsiella infections in premature infants]. | | 1975 | 1214331 |
| [the bacterial flora of the nasal mucosa of the horse. i. gram-negative bacteria (author's transl)]. | | 1975 | 1218849 |
| degradation of ioxynil and bromoxynil as measured by a modified spectrophotometric method. | a modified spectrophotometric method was developed to estimate ioxynil and bromoxynil residues. the method when compared with a 14c-tracer method was less sensitive but allowed rapid and accurate estimation of the herbicides. a clay loam soil with high organic matter content, which degraded ioxynil completely to co2, also degraded bromoxynil completely. bromoxynil degradation proceeded at a faster rate than that of ioxynil. the half-life of degradation was estimated to be 7 days for bromoxynil a ... | 1975 | 1220864 |
| [experiences of control measures against hospitalism (author's transl)]. | infection caused by gram negative germs in hospitals increased 14-fold since 1957 and measures today 66p.c. of hospital infection. the following causes are mainly responsible for this fact: inadequate hygienic measures, increased antimicrobial chemoprophylaxis and-therapy, changing pattern of antibiotic resistance, increased degree of severity of operations, and the mounting number of intensive care unit patients. 13 letal pneumonias and 1 peritonitis caused by klebsiella were observed in the de ... | 1975 | 1223612 |
| antibiotic sensitivity of bacteria from urine. | bacteria isolated from the urine of 400 hospital inpatients and 483 outpatients were identified and the in vitro sensitivity of these organisms against 12 antibacterial agents currently used in the treatment of urinary tract infections was determined. there was little difference in the distribution of organisms between the two groups. escherichia coli was predominant, accounting for 58% of the inpatients and 66% of the outpatients. klebsiella was present in 15% of the inpatients as against 7% in ... | 1975 | 1223719 |
| [septic shock. clinical review of 72 cases (author's transl)]. | the authors present a series of 72 observations of septic shock. the overall hospital mortality is 51%. aggravating factors with worst prognosis are a cirrhosis (90% mortality) and wrong antibiotics before shock occurred (88% mortality). some therapeutic acts (cannulae, venous catheter, urinary catheter, immuno-depressing treatment) increase penetration of gram positive germs of hostipal origin. the germs account for 30% of cases, the most frequent being staphylococcus. among gram-negative organ ... | 1975 | 1224890 |
| [light and electron microscopy of rhinoscleroma (author's transl)]. | the authors report the case of a 50 year old male patient whose rhinoscleroma, localized to the upper respiratory tract, was demonstrated by the isolation of klebsiella bacilli and histologically. electron microscopically the mikulicz cells were characterized by fused vacuoles occupying the largest portion of the cytoplasm and displacing the damaged cytoplasmic organelles. phagosomes and dense bodies reminiscent of russel bodies also occurred in the mikulicz cells, in the vacuoles of which forma ... | 1975 | 1225879 |
| [antibiotic prophylaxis in heart surgery. 3 years experience]. | | 1975 | 1232567 |
| [the bacterial infections in patients with acute leukemia and their treatment by antibiotics, with special reference to klebsiella and pseudomonas infections (author's transl)]. | | 1975 | 1236974 |
| biological activities of endotoxins detoxified by alkylation. | it has been previously observed that lipopolysaccharides can be detoxified by alkylation and yet retain their adjuvant activity. our present findings confirm these results and show, moreover, that these derivatives did not lose their capacity to protect mice against lethal irradiation and lost only partially their ability to interrupt pregnancy or to induce blast transformation of murine b-lymphocytes. however, in contrast with lipopolysaccharides, these alkylated preparations did not enhance th ... | 1975 | 1238369 |
| [classification of enterobacter and klebsiella]. | | 1975 | 1240305 |
| [congenital syphilis. apropos of 3 cases with early neonatal manifestations]. | three patients with early congenital syphilis are described. a slight degree of prematurity was a common feature. symptomatology consisted in a combination of various lesions of the skin, bones, respiratory and nervous systems. despite prompt initiation of therapy with penicillin, one patient died a few hours after birth. another patient's death was attributed to a secondary klebsiella overinfection. this demonstrates the severity of the syphilitic injury for the newborn infant when it manifests ... | 1975 | 1240885 |
| observations on an outbreak of klebsiella mastitis in sows. | | 1975 | 1241837 |
| [practical experiences in the campain against hospital infection]. | | 1975 | 1243463 |
| [glomerulonephritis following an infected ventriculoatrial shunt. report of 2 cases]. | two patients with shunt nephritis are reported. one of the patients had a positive blood culture to staphylococcus albus; the kidney biopsy showed an immune complex disease. in the second patient, klebsiella sp., was cultured in the blood, and this is the first report with such bacteria as the cause of nephritis. the finding of fibrin in the glomeruli by light, immunofluorescence and electron microsocopy studies, suggests a pathogenesis different from intravascular coagulation. in both patients, ... | 1976 | 1247468 |
| clinical management of acute cholangitis. | in a series of 78 patients with acute cholangitis, 48 were associated with common duct stones, and in one-third of these, the stones were believed to be primary common duct stones. even though the clinical presentation of acute cholangitis can be nonspecific with a remarkable absence of physical signs, almost all patients had elevations of serum bilirubin, transaminase and alkaline phosphatase levels, an indication of disease of the biliary tree. initially, all of the patients were treated with ... | 1976 | 1251317 |
| septic nonsuppurative thrombophlebitis. | nonsuppurative peripheral thrombophlebitis is a frequently recognized source of sepsis. eleven patients cared for on general medical and surgical services had gram-negative bacillary sepsis on this basis. ten had isolation of organisms of the klebsiella-enterobacter group from the involved peripheral vein. all failed to respond to organism-sensitive antibiotics until the involved vein was excised. after local vein excision, all patients were afebrile within 48 hours and recovered. in seven of th ... | 1976 | 1252117 |
| sinus histiocytosis with massive lymphadenopathy: fifteen new cases. | fifteen cases of chronic lymphadenitis with massive hemophagocytic sinus histiocytosis were analyzed. fourteen patients were whites, 13 were europeans, and 11 were males; 10 patients were under 10, 4 were over 20, and 2 over 60 years old. the oldest patient died; all other either healed without therapy or are in excellent condition. we studied the cytologic features of lymph node imprints. a 5-year-old girl was examined more thoroughly. high antibody titers to klebsiella antigens were found repe ... | 1976 | 1253107 |
| the quantitative swab culture and smear: a quick, simple method for determining the number of viable aerobic bacteria on open wounds. | the quantitative swab culture is a reliable method for quantifying the number of viable bacteria colonizing open wounds. for open wounds in burn patients, the swab bacterial count is linearly related to biopsy quantification of viable bacteria in the underlying tissue. this technique is simple and requires no surgical manipulation of the wound. for a wound of uniform appearance, the standard deviation of a single swab culture from the mean log bacterial count for a series of cultures from widely ... | 1976 | 1255833 |
| infection and mortality in captive wild-trapped canvasback ducks. | fungal, bacterial and malarial infections, as well as malnutrition caused heavy mortality in a group of wild-trapped canvasbacks (aythya valisineria) held in 10 x 3 x 2 m open-water pens. deaths occurred between 21 and 158 days after confinement and were associated with infections of aspergillus fumigatus, escherichia coli, staphylococcus sp., streptococcus sp., klebsiella sp., enterobacter sp., and plasmodium sp. infection and mortality was believed to result from reduced resistance associated ... | 1976 | 1255909 |
| epidemiologic aspects of nosocomial infections. | in a currently ongoing surveillance of hospital-associated infections in two metropolitan hospitals in oklahoma, the results over a four-month period suggest at least tentative principles of host-agent relationships in hospital-associated infections. within the urinary tract, the site with the highest number of total isolations, escherichia coli and klebsiella pneumoniae were the most common pathogens. by age, the under 5 and over 60 year age groups had the highest number of isolations. staphylo ... | 1976 | 1257828 |
| [possible relationship between bacterial surface structures, immune-adherence, chemotaxis and phagocytosis (author's transl)]. | in the present study we attempted to determine the relationship between bacterial surface structures, immune adherence, chemotaxis and phagocytosis. as shown in table 1 encapsulated bacteria (klebsiella ozanae, k. pneumoniae, pasteurella multocida, streptococcus pneumoniae), mycoplasma pneumoniae and m. fermentans had a much lower immune adherence-activity than non-encapsulated bacteria (bacillus cereus, brucella abortus, erysipelothrix insidiosa, escherichia coli, listeria monocytogenes, pseudo ... | 1976 | 1258564 |
| in vitro activity of bl-s640 against gram-negative bacilli and staphylococcus aureus compared with activity of four other semisynthetic cephalosporins. | the in vitro activity of bl-s640 (cefatrizine) was determined against 674 recent clinical isolates of staphylococcus aureus and enterobacteriaceae. activity against s. aureus was less than that of cephapirin, cephalothin, and cefazolin, but greater than that of cephalexin. activity against gram-negative isolates was variable: bl-s640 was slightly less potent than cefazolin against escherichia coli and klebsiella, but more active than the other compounds. as for the more resistant gram-negative g ... | 1976 | 1259401 |
| efficacy of cinoxacin in urinary tract infections. | cinoxacin, a new synthetic antibacterial agent with in vitro activity against all species of enterobacteriaceae, was used in the treatment of urinary tract infections in 20 patients. the dose of cinoxacin was 250 mg orally every 6 h for 10 days. the etiological agents were escherichia coli in fifteen, klebsiella-enterobacter in five, proteus mirabilis in two, and providencia in one. the minimal inhibitory concentration for these organisms ranged from 2 to 64 mug/ml. eleven of the 20 patients had ... | 1976 | 1259405 |
| cefuroxime, a new cephalosporin antibiotic: activity in vitro. | cefuroxime is a new broad-spectrum cephalosporin antibiotic with increased stability to beta-lactamases. this stability, although no absolute in all cases, has the effect of widening the antibacterial spectrum of the compound so that many organisms resistant to the established cephalosporins are susceptible to cefuroxime. it is active against gram-positive organisms, including penicillinase-producing staphylococci, but it is less active against methicillin-resistant strains. in addition to its h ... | 1976 | 1259407 |
| bioenergetic aspects of aerobic growth of klebsiella aerogenes nctc 418 in carbon-limited and carbon-sufficient chemostat culture. | carbon-limited chemostat cultures of klebsiella aerogenes nctc 418 consumed more oxygen per unit of cell synthesis when growing on mannitol or glycerol than when growing on glucose; and since the "maintenance" requirements were similar, this suggested that the extra reducing equivalents present in these compounds were oxidized wastefully. by comparison with carbon-limited cultures, carbon-sufficient cultures that were ammonia-, sulphate- or phosphate-limited generally consumed considerably more ... | 1976 | 1259519 |
| [unilateral ozena in an 11-month-old infant]. | | 1976 | 1260915 |
| ammonia-sensitive mutant of klebsiella aerogenes. | we have isolated a temperature-sensitive mutant of klebsiella aerogenes unable to grow aerobically at 42 c in standard glucose minimal medium containing 0.03 m ammonium sulfate as a source of nitrogen. this strain, mk810, will grow at this temperature in significantly lower concentrations of ammonia (1 mm) or when ammonia is replaced by a growth rate-limiting source of nitrogen such as histidine or glutamate. a detailed physiological characterization and preliminary biochemical tests support the ... | 1976 | 1262316 |
| [experience with amoxicillin therapy in urological field (author's transl)]. | amoxicillin (ampc), an oral preparation of broad spectrum synthetic penicillin, was used for treatment of 10 cases with urological infection, and the following results were obtained. 1. ampc at a daily dose of 750 approximately 1,500 mg was administered for 7 approximately 49 days to 5 cases of acute cystitis, 2 cases of acute epididymitis and one case each of calculous hydronephrosis, chronic prostatitis and postoperative cystitis. as the result, ampc was found remarkably effective in 2 cases, ... | 1976 | 1263340 |
| cephazolin treatment of pneumococcal pneumonia and urinary tract infections. | ten cases of pneumococcal pneumonia were treated with cephazolin 500 mg. q8h for at least 5 days. in every case therapy was accompanied by clinical improvement and eradication of the organism. ten patients with e. coli bacteriuria (5 symptomatic) were treated with cephazolin 500 mg. q12h for 7 to 10 days. in every case the pathogen was eliminated during therapy but in one case bacteriologic relapse occurred following cessation of therapy. in 10 cases of bacteriuria caused by p. mirabilis, klebsi ... | 1976 | 1265474 |
| synergy of mecillinam (fl1060) with penicillins and cephalosporins against proteus and klebsiella, with observations on combinations with other antibiotics and against other bacterial species. | thirty-five strains each of klebsiella and proteus were tested for susceptibility to mecillinam alone and in combination with ampicillin, carbenicillin, cephalothin, and cefazolin. antibiotics were considered to be synergistic when there was a >/=fourfold reduction in minimum inhibiting concentration of both antibiotics in the combination as compared with that of each antibiotic alone. synergy of mecillinam with ampicillin, carbenicillin, cephalothin, and cefazolin was demonstrated against 2, 3, ... | 1976 | 1267442 |
| [studies on the flora of the genital- and nasal mucosa of horses, especially of stallions with bacterial pathogens important in horse breeding and with particular reference to klebsiella. iii. serologic studies on klebsiellas]. | | 1976 | 1267751 |
| studies on the flora of the genital - and nasal mucosa in horses, especially stallions with bacterial pathogens important in horse breeding and with special reference to klebsiellas. 2. morphologic and biochemical studies on klebsiellas. | | 1976 | 1267756 |
| emphysematous pyelonephritis. | emphysematous pyelonephritis is a rare complication of urinary tract infection and generally occurs in patients with diabetes mellitus or urinary tract obstruction. we recently treated an 81-year-old diabetic woman with klebsiella pneumoniae urinary tract infection and septicemia whose abdominal roentgenogram demonstrated a striking left pneumonephrogram as well as intraureteral and perirenal gas. the patient died despite intensive therapeutic efforts. unfortunately, the prognosis for this sever ... | 1976 | 1271561 |
| [gentamicin therapy of infectious diseases by pathogens (author's transl)]. | gentamicin (gm) was intramuscularly injected to 29 patients with various infections in the doses of 40-60 mg twice a day. the maximum dose was 1,800 mg. satisfactory clinical results were obtained in the treatment of not only urinary tract infections but also respiratory tract infections, bile duct infections and others. this clinical results would coincide with the fact that almost all organisms isolated had a high sensitivity to gm. no significant abnormal findings was observed in this clinica ... | 1976 | 1271580 |
| [clinical trials with amoxicillin (pasetocin 'kyowa') on infections of respiratory apparatus (author's transl)]. | amoxicillin at a daily dose of 1-1.5 g was orally administered to total 30 cases comprising 6 of acute tonsillitis, 6 of chronic tonsillitis, 8 of acute bronchitis, 4 of chronic bronchitis, 4 of bronchiectasis, 1 of suppurative diseases of the lung and 1 of exudative pleurisy. the clinical results and side effects are reported. 1. the effect of amoxicillin was remarkably good in 15 of 30 cases with infections of respiratory apparatus (50%), good in 7(23%), poor in 5(17%) and unknown in 3(10%); t ... | 1976 | 1271587 |
| [experimental basis of chemotherapy of ozena]. | | 1976 | 1274090 |
| treatment of anaerobic pulmonary infections; carbenicillin compared to clindamycin and gentamicin. | twenty-three patients with anaerobic infections of the lung were treated with either two antibiotics, clindamycin and gentamicin (11 patients) or with a single antibiotic, carbenicillin (12 patients). cultures were obtained prior to therapy, either by transtracheal needle aspiration (17 patients) or thoracocentesis (six patients). anaerobic bacteria were found in all. fifteen patients had aerobic and facultative bacteria in addition. the anerobic isolates were peptostreptococci (12), peptococci ... | 1976 | 1277892 |
| the enzyme complex citramalate lyase from clostridium tetanomorphum. | 1. the enzyme citramalate from clostridium tetanomorphum is not stable in crude extracts. however, the inactive enzyme can be reactivated by incubation with dithioerythritol followed by acetylation with acetic anhydride. reactivation was also obtained with acetate, atp, mgcl2 and acetate : sh-enzyme ligases (amp) from c. tetanomorphum or klebsiella aerogenes. 2. incubation of the inactive enzyme with iodoacetate resulted in rapid loss of enzymic activity as determined by reactivation with acetic ... | 1976 | 1278156 |
| effect of the substitution of critical residues on the allorecognition of hla-b27. | the three-dimensional structure of the hla class i molecules has highlighted the importance of the "groove" formed by the helices. we used site-directed mutagenesis to construct a series of hla-b27 mutants with different substitutions at the sites of the conserved amino acid residues of hla-b27 subtypes, specifically residue 77 which is thought to be critical to the binding site of the molecule, and a residue at the cd8 binding site. we formed an anti-b27 ctl line and derived six anti-b27 clones ... | 1992 | 1282853 |
| [bacterial ecology of the digestive tract and defense of the body]. | the indigenous microflora of the upper digestive tract is poorly developed and consists of microorganisms in transit, originating in the oro-pharynx. aerobic bacteria, mainly streptococci, predominate. in the normohydrochloric stomach, the mean fasting bacterial concentration is 10(3)-10(4)/ml gastric juice. in the small intestine, levels of up to 10(5) bacteria/ml contents are reached. the essential mechanism which maintains this relative sterility of the upper digestive tract is the gastro-int ... | 1992 | 1285634 |
| [urinary tract infections in patients with incontinence problems]. | | 1992 | 1286324 |
| leishmania major: bacterial contamination of cutaneous lesions in experimental animals. | no bacterial contamination has been demonstrated in cutaneous leishmaniasis (cl) nodule and in lesions caused by leishmania major in balb/c mice up to 20 days after infection. however, although many phagocytic cells (polymorphonuclear leukocytes and macrophages) were present in the cl lesion, 80% of the lesions showed bacterial contamination that developed within the first 70 days of infection. topical treatment of the lesion with an ointment containing 15% paromomycin and 12% methylbenzethonium ... | 1992 | 1286954 |
| hla and disease. | many human diseases are associated with hla class i, class ii and class iii antigens. it appears that the class iii antigen disease associations can be explained by a direct defect operating at the level of either the class iii gene or its gene product. the mechanism underlying class i and class ii antigen disease associations is at present unknown. in this review we have considered thirty diseases which have been ranked according to their relative risk as defined by the frequency of a given hla ... | 1992 | 1287396 |
| cross reactivity between klebsiella pneumoniae and ocular tissue. | klebsiella pneumoniae has been implicated as a possible aetiological agent in ankylosing spondylitis and acute anterior uveitis. cross-reactivity between antigens of klebsiella and bovine vitreous has been reported. in the present study sera from rabbits immunised with klebsiella pneumoniae was tested against fresh guinea pig and human ocular tissues using immunodiffusion and immunofluorescent methods. no cross-reactivity between klebsiella and the ocular tissues used could be demonstrated by th ... | 1992 | 1288247 |
| studies on induction of metachromasy in cationic dye pinacyanol chloride by klebsiella k7 capsular polysaccharide. | the acidic capsular polysaccharide isolated from klebsiella k7 induced metachromasy in the cationic dye pinacyanol chloride indicating its chromotropic character. interaction of the biopolymer with the cationic dye was studied by visible absorption spectrophotometry, and thermodynamic parameters of the interaction evaluated. the polymer induced a metachromatic blue shift in the spectrum from 600 nm to 495 nm. the spectral changes were studied during interaction of the dye with the polymer at dif ... | 1992 | 1289231 |
| structure of the o-specific polysaccharide chain of klebsiella pneumoniae o1k2 (nctc 5055) lipopolysaccharide. a complementary elucidation. | | 1992 | 1291059 |
| the comparative activity of fosfomycin trometamol against organisms isolated from infected urines. | five hundred urinary pathogens, collected from patients of general practitioners and hospital in-patients, were identified and tested for susceptibility to fosfomycin, ampicillin, cephalexin, nalidixic acid, nitrofurantoin, trimethoprim and sulfamethoxazole. overall, 83% of the isolates were sensitive to fosfomycin, comprising 89% of the out-patient strains and 77% of the in-patient isolates. this degree of sensitivity was similar to that of cephalexin, nalidixic acid and trimethoprim, but highe ... | 1992 | 1294522 |
| the influence of anaerobiosis on the activity of fosfomycin trometamol. | mics of fosfomycin trometamol were estimated for 40 strains of bacteria (20 gram-positive cocci, 20 gram-negative bacilli) by the agar incorporation method (iso-sensitest agar) in the presence of the potentiating agent, glucose-6-phosphate (25 mg/l). titrations were carried out in duplicate under aerobic and anaerobic conditions. for 22 strains (12 gram-negative bacilli), a fourfold or greater reduction in mic was observed in tests conducted under anaerobic conditions. the effect was particularl ... | 1992 | 1294523 |
| injection sclerotherapy as a cause of klebsiella pneumoniae peritonitis. | we report a case of klebsiella pneumoniae peritonitis after endoscopic sclerotherapy and discuss its pathogenesis and risk factors. we also review previous cases in the literature and make recommendations for prophylactic therapy. endoscopists should be aware of peritonitis as a possible complication of endoscopic sclerotherapy. | 1992 | 1294640 |
| campylobacter jejuni in acute diarrhoea in infancy and its relation to faecal leucocytic count. | a prospective study was carried out to identify the relative risk of campylobacter jejuni infection in 50 infants with acute diarrhoea, 24 infants with acute resistant diarrhoea and 25 healthy normal infants as a matching control group. faecal samples were collected from the three groups and were cultured on both selective media for campylobacter and other media for isolation of other organisms. direct stool smears, stained with methylene blue, were examined for detection of faecal leucocyte in ... | 1992 | 1295942 |
| gentamicin resistance in fatal klebsiella septicaemia. | the occurrence of antibiotic resistance in nosocomial infections is a common problem. this case details a fatality associated with klebsiella infection acquired as a hospital inpatient. the transfer of gentamicin resistance between gram-negative bacteria could present a considerable problem in papua new guinean hospitals. | 1992 | 1296423 |
| inhibition of salmonella ferlac by enterobacteria under in-vitro conditions. | interactions of proteus morganii, proteus mirabilis, proteus sp. klebsiella oxaenae and serratia marcescens isolated from vegetable salads of mass feeding systems with salmonella ferlac (a new subgenus vi of salmonella) isolated from a hostel cook's hands and lizard droppings were recorded following in-vitro nephelometric analysis. nephelometric analysis revealed inhibition of s. ferlac by all the tested isolates from fifth hour of mixed culture interaction. k. oxaenae was the strong inhibitor. | 1992 | 1296949 |
| [comparative in vitro susceptibility of clinical bacterial isolates to pefloxacin and 14 antibiotics]. | in vitro activity of pefloxacin against 782 bacterial strains isolated from hospitalized patients (july-september 1991) in wrocław was compared with that of 14 antibiotics (4 aminoglycosides and 10 beta-lactamase). the most susceptible to pefloxacin were: staphylococcus epidermidis (96.0%), klebsiella (94.4%), proteus mirabilis (93.8%) and escherichia coli (92.7%). the least susceptible proved to be: nonfermentative gram-negative rods (46.5%), and among them pseudomonas aeruginosa (19.3% weakly ... | 1992 | 1297147 |
| [role of enteric klebsiella pneumonia infection and hla-b27 in ankylosing spondylitis]. | klebsiella pneumonia (kp) infection and hla-b 27 have been shown to be strongly associated with ankylosing spondylitis (as). in the present study, faecal cultures were performed and showed faecal carriage rate of kp was much higher in patients with as (10/30) and hospital volunteers (2/10) than in the non-hospital volunteers (0/20). an octadecapeptide encompassing the shared hexamer between hla-b 27 and kp nitrogenase residue was synthesized and autoantibodies against this short peptide were det ... | 1992 | 1298592 |
| bacteriuria in patients with glomerular diseases. | in a comparative study of significant bacteriuria in an african population, 1.7% of 697 healthy subjects (10 females and 2 males) were found to have positive urine cultures. of these, 5 subjects grew e. coli, 4 klebsiella strains, 2 staphylococcus aureus and 1 serratia marcescens. among 116 patients with glomerular disease, 15.5% (7 males and 11 females) yielded positive cultures. e. coli, staph. aureus and proteus species were commonly isolated organisms. there was a nine fold increase in preva ... | 1992 | 1298612 |
| [urinary tract infections at the hospital and the ambulatory service: etiology and laboratory diagnosis]. | an aetiology study was conducted into urinary tract infections (uti) in order to compare hospital infections with those in outpatients identified from samples sent to the laboratory by general practitioners. urine culture analysis was performed on 3,483 samples of which 740 came from hospital patients and 2,743 from outpatients. the diagnosis of uti was based on new criteria: not only the assessment of bacterial proliferation but also clinical factors like sex, symptoms, sampling technique and u ... | 1992 | 1299002 |
| pilot studies on the occurrence of some infectious diseases in two different areas in south yemen (aden) (part ii. microbiology). | this paper is the second part of the article dealing with intestinal bacteria. the findings are relatively poor in comparing with the frequency of intestinal protozoa. among 83 stool specimens taken for bacteriological examination 14 isolations of different bacteria were proved. one s. muenchen was isolated from a 3 year old boy with fever, diarrhoea. five cases of alkalescens dispar 05 manit negative and 05 manit positive were identified. two of these cases were without clinical symptoms. all w ... | 1992 | 1300359 |
| antigen-binding diversity of human hybridoma autoantibodies derived from splenocytes of patients with sle. | the antigen-binding specificity of human hybridoma-derived monoclonal autoantibodies (mab) was analysed with mabs derived from the spleens of two patients with active systemic lupus erythematosus (sle). from one patient 72 mabs (rsp clones) and from the other 173 mabs (rt clones) were obtained. the binding specificity of these mabs was analysed by solid- and fluid-phase elisa against the autoantigens ssdna, dsdna, cardiolipin, smrnp, histones, sm-d and ss-b (la) synthetic peptides, and foreign a ... | 1992 | 1301976 |
| [resistant rate to antibiotics in tian tan hospital for 3 years]. | the resistance to antibiotics of the 985 clinical isolates collected in tian tan hospital was studied. the results showed that s. aureus had a resistant rate of more than 90% to penicillin and was also highly resistant to erythromycin. methicillin resistant staphylococcus aureus (mrsa) was isolated in 15.6% of all the isolates with s. aureus. the isolation rate of mrsa is lower than that in other countries or districts of west pacific area. k. pneumonia and other gram negative bacilli had a resi ... | 1992 | 1303851 |
| percutaneous debridement of complex pyogenic liver abscesses. | the author's approach and technique in the treatment of complex liver abscesses that persisted or recurred following percutaneous drainage are described. six patients were treated by percutaneous debridement using an instrument specially designed for that purpose. four patients were chronically ill but stable, while the other two were septic, hypotensive and considered to be life threatened. all patients had primary pyogenic abscesses. four had demonstrated mixed bacterial flora consisting of e. ... | 1992 | 1304464 |
| antimicrobial resistance: patterns and trends in the national university hospital, singapore (1989-1991). | the commonly isolated organisms, staphylococcus aureus, escherichia coli, klebsiella species, pseudomonas aeruginosa, acinetobacter species, proteus species and enterobacter species from clinical material other than blood, cerebrospinal fluid and stool, were analysed for their incidence and increasing trends of resistance to the commonly used antimicrobials. staphylococcus aureus was tested against penicillin, methicillin, erythromycin, gentamicin and co-trimoxazole; pseudomonas aeruginosa again ... | 1992 | 1304631 |
| a proposed link between nitrogen and carbon metabolism involving protein phosphorylation in bacteria. | we demonstrate that certain phosphoryl transfer proteins of the bacterial phosphotransferase system (pts), the fructose- and mannitol-specific iia proteins or domains, are homologous to a class of proteins, one of which is known to affect transcription of some of the nitrogen-regulatory sigma 54-dependent operons in klebsiella pneumoniae. the phosphorylatable histidyl residue in the homologous pts proteins and the consensus sequence in the vicinity of the active-site histidine are fully conserve ... | 1992 | 1304914 |
| anti-infectious effect of c granulosum-derived p40 immunomodulator given by aerosolization and intranasal instillation. | it is known that c granulosum-derived p40 immunomodulator displays strong anti-microbial effects in mice by the intravenous route. since microbial contamination of humans occurs in many instances via the airways, the effect of p40 on infections was investigated when it was given intranasally or by aerosolization. in order to augment its bioavailability, p40 was derivatized by coupling with polylysine chains (p40-pl). the results showed that p40-pl exercised a significant protective effect, both ... | 1992 | 1306363 |
| klebsiella pneumonia with lung abscess in a male child. | an unusual presentation of klebsiella pneumonia with lung abscess in a male child with no apparent predisposing factor is described. | 1992 | 1307548 |
| [neonatal bacterial meningitis: etiological agents in 109 cases during a 10 year period]. | the etiology of purulent meningitis was investigated in 109 newborn infants admitted in a neonatal intensive care unit throughout a ten year period. bacterial pathogens were isolated from the csf in 57 (52.2%) neonates. there was a predominance of gram-negative bacilli isolated in 38 (34.9%) neonates. gram-positive cocci were isolated from csf in only 12 (11.0%) neonates. microorganisms associated with nosocomial septicemia and meningitis in neonates--klebsiella sp, salmonella sp. enterobacter s ... | 1992 | 1308405 |
| antimicrobial resistance of 100 serial gram-negative isolates in two intensive care units. | to determine antimicrobial resistance pattern among gram-negative bacteria isolated from suspected sources of infections in patients hospitalized in two intensive care units (icus) at siriraj hospital from september 1991 to december 1991, minimal inhibitory concentrations of one-hundred consecutive gram-negative isolates for various antimicrobials were performed using the microbroth dilution method. of all gram-negative bacterial isolates, 25 per cent were pseudomonas aeruginosa, 22 per cent aci ... | 1992 | 1308536 |
| [comparative activities in vitro of 4 quinolones (nalidixic acid, pefloxacin, norfloxacin, ofloxacin) on 13 bacterial species]. | nalidixic acid and three fluoroquinolones were tested on 389 strains belonging to 13 bacterial species, all isolated in algeria. ofloxacin, norfloxacin and pefloxacin have the same activities on e. coli, acinetobacter and s. aureus. norfloxacin has the best activity on proteus, enterobacter, shigella and klebsiella. norfloxacin and ofloxacin have the same activities on s. typhi, salmonella and choleric vibrio. norfloxacin has the same activity than pefloxacin on p. aeruginosa. it is necessary to ... | 1992 | 1309146 |
| detection of ciprofloxacin resistance in gram-negative bacteria due to alterations in gyra. | two plasmids containing the cloned escherichia coli wild-type gyra gene were used to transform ciprofloxacin-resistant gram-negative clinical isolates to screen for dna gyrase a-mediated quinolone resistance. the results show that the technique is simple and applicable to a wide range of gram-negative species including e. coli, enterobacter cloacae, klebsiella aerogenes, morganella morganii, proteus mirabilis, pseudomonas aeruginosa, campylobacter jejuni and neisseria gonorrhoeae. the use of an ... | 1992 | 1310671 |
| adherence to respiratory epithelia by recombinant escherichia coli expressing klebsiella pneumoniae type 3 fimbrial gene products. | we examined the role of klebsiella fimbrial types 1 and 3 in mediating adherence to human buccal and tracheal cells and to lung tissue sections. we found that clinical isolates of klebsiella pneumoniae producing type 3 fimbriae and escherichia coli hb101 containing a recombinant plasmid encoding expression of klebsiella type 3 fimbriae (pfk10) demonstrated increased adherence to tracheal cells, trypsinized buccal cells, and lung tissue sections, in contrast to nonfimbriate and to type 1 fimbriat ... | 1992 | 1312518 |
| cloning and characterization of pathogenicity genes from xanthomonas campestris pv. glycines. | nonpathogenic mutants of xanthomonas campestris pv. glycines 8ra were generated with n-methyl-n-nitro-n'-nitrosoguanidine to identify and characterize pathogenicity genes of the bacterium. a total of 16 nonpathogenic mutants were isolated from 2,000 colonies. one mutant, np1, was chosen for further study. np1 did not multiply in soybean cotyledons. a genomic library of strain 8ra was constructed in the cosmid plafr3, and the cosmids were tested for complementation in np1. one cosmid clone, pih1, ... | 1992 | 1312532 |