| the role of aspergillus fumigatus antigens in blood coagulation and platelet function. | the effects of aspergillus fumigatus antigens on platelet function of rabbits was studied. a. fumigatus antigens produced spontaneous and irreversible aggregation of platelets. aspirin, indomethacin or lidocaine did not block the antigen-induced aggregation. however, no aggregations occurred when complement depleted plasma was used. no differences were noted between the strains used. our findings show that soluble aspergillus antigens can cause platelet aggregation in vitro, possibly via a compl ... | 1980 | 7010083 |
| case report: antemortem diagnosis of disseminated aspergillosis by nasal scraping. | | 1980 | 7012447 |
| enzootic aspergillosis in wild red vented cockatoos in the philippines. | philippine red vented cockatoos were being trapped in the wild and dispersed directly to private homes, aviaries, pet stores and for export to the united states of america. except for non-aggressive behaviour and tiring easily the subjects showed clinically nothing peculiar. numerous cases of aspergillosis with no clinical signs prior to death were being reported at the united states air force base, clark field, angeles city, philippines. in all cases stress was a predisposing factor to death; s ... | 1981 | 7012630 |
| a new species of aspergillus fumigatus group and comments upon its synonymy. | aspergillus fumigatus fries, acolumnaris rai et al. (1) has been raised to a distinct epithet and four different varieties of a. fumigatus (1--2 & 6) viz. a. fumigatus fries. var. albus rai et al., a. fumigatus fries. var. grisei-brunneus rai and singh, a. fumigatus fries. mut. helvola yuill and a. fumigatus fries. var. sclerotiorum rai et al. which were recognised by earlier workers, have also been merged into a. fumigatus. | 1981 | 7012634 |
| survey of human pathogenic actinomycetes and fungi in soil from rome and other italian areas. | as part of a study sponsored by the ministry of health of italy, a research program on pathogenic actinomycetes, keratinophilic and pathogenic fungi in soil was carried out. two hundred soil samples, collected from different areas of the city of rome, calabria, emilia romagna, latium, apulia, sardinia, sicily, tuscany and umbria, were examined by several techniques to detect the widest possible variety of pathogenic actinomycetes and fungi. seven isolates of nocardia asteroides, four of actinoma ... | 1981 | 7012635 |
| further evaluation of indirect immunofluorescence methods for detection of antibodies against aspergillus fumigatus. | the if titres of igg antibodies to hyphal antigen preparations of 6 isolates of aspergillus fumigatus were compared with the titres to germling antigen preparations of the same isolates. titres varied according the antigen used and the method of preparation. no single isolate or method of antigen preparation enabled a group of 15 patients with aspergillosis to be separated from a group of asthmatic subjects or a group of patients with other fungal infections, but significantly higher means if ti ... | 1981 | 7013114 |
| fatal childhood pulmonary aspergillosis from contact with pigeons. | | 1981 | 7014070 |
| sequential cold-sensitive mutations in aspergillus fumigatus. ii. analysis by the parasexual cycle. | from aspergillus fumigatus i-21 (atcc 32722), which grows at temperatures from 12 to 50 degrees c, three multistep, independently derived, cold-sensitive mutants unable to grow at 37 degrees c or below (cs-37) were obtained by sequential exposure to ethylmethane sulfonate (strain at2) or n-methyl-n'-nitro-n-nitrosoguanidine (at1 and at3). these mutants and on5, a five-step cs-37 mutant, were marked by mutations affecting spore color and nutritional requirements and crossed in four combinations b ... | 1981 | 7016281 |
| sequential cord-sensitive mutations in aspergillus fumigatus. iii. mechanism of cold sensitivity. | the mechanism of cold sensitivity of aspergillus fumigatus on5, a 37 degrees c-sensitive mutant derived from a. fumigatus i-21 (atcc 32722) by five sequential mutations, was investigated. the rate of in vivo protein synthesis by on5 was not affected for 2 h following a shift from 45 to 34 degrees c, but the rate of in vivo rna synthesis dropped almost immediately. the rna polymerases 2 h following a shift from 45 to 34 degrees c, but the rate of in vivo rna synthesis dropped almost immediately. ... | 1981 | 7016282 |
| skin tests in a primate model of allergic bronchopulmonary aspergillosis. | we have previously reported producing a primate model of allergic bronchopulmonary aspergillosis in which monkey precipitating igg and transfused human ige antibodies against aspergillus fumigatus (af) combined with aerosolized af to produce an inflammatory response in the lung. in this study we attempt to demonstrate similar changes in the skin. immunized and unimmunized monkeys with and without igg precipitating antibody to af were injected at multiple sites intradermally with normal human ser ... | 1981 | 7016762 |
| immunologic studies of disseminated infection with aspergillus fumigatus in the nude mouse. | immunity to infection with aspergillus fumigatus conidia was studied in the athymic nude (nu/nu) mouse. the intratracheal, intravenous, and intraperitoneal routes of infection were used. nu/nu mice were not significantly more susceptible than their heterozygous (nu/+) littermates. however, only nu/+ animals could be protected by prior immunization and developed positive, a. fumigatus-specific skin tests. protection could be transferred to nu/nu recipients by immune glass-adherent cells. thus, im ... | 1981 | 7017022 |
| aspergillus endocarditis in children: case report and review of the literature. | aspergillus fumigatus endocarditis developed in a 2 1/2-year-old girl after repair of tetralogy of fallot. there have been 14 other cases of aspergillus endocarditis in children described in the literature. fever and embolic phenomenon, particularly to the cns, were the most common presenting manifestations. consumptive coagulopathy developed in this patient as it has in other children and should suggest the diagnosis of aspergillus endocarditis inasmuch as blood cultures are uniformly negative. ... | 1981 | 7017583 |
| a study of immunoglobulin g subclasses in patients with allergic bronchopulmonary aspergillosis. | | 1981 | 7018738 |
| defective aspergillus killing by neutrophil leucocytes in a case of systemic aspergillosis. | a persistent defect of aspergillus killing was observed in the neutrophils of a 6-year-old patient with a systemic a. fumigatus infection which was highly refractory to anti-mycotic therapy. aspergillus phagocytosis in vitro was normal, but nearly 80% of the ingested organisms (versus 30% in the controls) survived intracellularly during the 2-hr assay period. the patient's neutrophils showed a subnormal frequency of nitroblue tetrazolium reduction and a subnormal hexose monophosphate shunt activ ... | 1981 | 7018757 |
| physico-chemical properties of the acid proteinase from a. fumigatus. | the physico-chemical properties of the purified acid proteinase were investigated. this enzyme was found to hydrolyze hemoglobin maximally among the different substrates used. the maximum hydrolysis of hemoglobin was found at ph 2.8 and 45 degrees c in 30 min. km value of 5.5 x 10(-4) m was obtained from the lineweaver burk plot for the hydrolysis of hemoglobin. the enzyme was found to be most stable at ph 4.9. the maximum stability of the enzyme was observed with 2 per cent casein as a stabilis ... | 1981 | 7019156 |
| [chemistry, action and pathogenic significance of fungal toxins]. | | 1980 | 7019485 |
| the effect of 5-fluorocytosine on the germination of aspergillus fumigatus and on subsequent nuclear division. | 5-fluorocytosine (5fc) inhibits the germination of the conidia of a. fumigatus. this is different from the lack of effect of 5fc on hyphal formation from blastospores of c. albicans because, unlike c. albicans, a. fumigatus requires dna synthesis for germination, and this is inhibited by 5fc. a modified fluorescent feulgen method has been developed to stain fungal nuclei in the presence and absence of 5fc. this method has shown that hyphae treated with 5fc have fewer nuclei than untreated hyphae ... | 1981 | 7020112 |
| immunodiagnosis of invasive pulmonary aspergillosis in rabbits. fungal antigen detected by radioimmunoassay in bronchoalveolar lavage fluid. | to improve antemortem diagnosis of invasive pulmonary aspergillosis, we used a radioimmunoassay to detect an aspergillus fumigatus antigen in bronchoalveolar lavage fluid (balf) and evaluated this technique in a model of disseminated aspergillosis. antigen was detected in 91% of balf samples obtained from 11 rabbits with major pulmonary aspergillosis. in an additional 10 rabbits with only minor pulmonary involvement, antigen was detected in 40% of concentrated lavage samples. in contrast, antige ... | 1981 | 7020504 |
| aspergillus pneumonia in an ostrich (struthio camelus). | | 1981 | 7020676 |
| mycotic emboli of the peripheral vessels: analysis of forty-four cases. | two cases of mycotic emboli of the peripheral vessels are presented, and 42 additional cases from the literature are analyzed. male patients predominate 3:1. candida and aspergillus are the usual pathogens. initial presentation as large vessel peripheral emboli is characteristic (77%), with emboli originating from either the aortic or mitral valves. cerebral emboli may proceed of follow the peripheral embolization. predisposing factors include open-heart surgery, antibiotic therapy, concomitant ... | 1981 | 7022728 |
| aspergillus fumigatus and specific precipitins in dogs with turbinate changes. | | 1981 | 7023015 |
| cultural and nutritional studies of zoopathogenic fungi associated with livestock feeds in nigeria. | mycelial growth and nutritional physiology of zoopathogenic aspergillus fumigatus fres., thermoascus aurantiacus miehe, and thermomyces lanuginosus tsik., obtained from livestock feeds and poultry droppings in nigeria were studied. an optimal ph-temperature range of 5.5-6.5 and 37 degrees - 45 degrees c was recorded for the growth of these fungi. various sources of carbon supplied in the growth medium, except sorbose and rhamnose, were utilized for growth. only aspergillus fumigatus caused consi ... | 1981 | 7023082 |
| studies on the peptide bond specificity and the essential groups of an acid proteinase from aspergillus fumigatus. | the specificity and mode of action of an acid proteinase from a. fumigatus was studied with b-chain of insulin, angiotensin ii and bradykinin. with reference to the known structure of the b-chain of insulin and angiotensin ii, the major sites of action were determined. acid proteinase of a. fumigatus hydrolyzed primarily three peptide bonds in the b-chain of insulin viz. i. his(5)-leu(6); ii. tyr(16)-leu(17) and iii. phe(24)-phe(25) bonds. additional cleavages of the bonds his(10)-leu(11) and le ... | 1981 | 7024192 |
| [changes in the soluble intracellular protein composition of aspergillus fumigatus as affected by trace elements]. | | 1981 | 7024742 |
| allergic bronchopulmonary aspergillosis with low serum immunoglobulin e. | elevated total serum ige is helpful in making the diagnosis of abpa and in monitoring the onset of exacerbations and response to therapy. abpa occurs frequently in patients with cf, and in these instances a high total serum ige is seen. this is the first case report of abpa without an elevated total serum ige level. at no time prior to this patient's first episode of abpa, at the time of the illness, or at monthly intervals during follow-up did her total serum ige level exceed 29 iu/ml. | 1981 | 7026647 |
| [a case of hypersensitivity pneumonitis due to aspergillus fumigatus (author's transl)]. | | 1981 | 7026850 |
| [foreign bodies in the chest with aspergillus fumigatus infection of surrounding tissues]. | | 1981 | 7027194 |
| [pulmonary aspergillosis and the characteristics of its course in ankylosing spondylitis complicated by pulmonary fibrosis]. | | 1981 | 7027195 |
| [results of 5-fluorocytosine therapy of aspergillosis and candidiasis]. | | 1981 | 7027197 |
| [clinical analysis of the causes of pulmonary hemorrhage]. | | 1980 | 7027207 |
| precipitating antibodies to farmer's lung antigens in a wisconsin farming population. | the prevalence of farmer's lung disease and antibodies to farmer's lung antigens were studied in a probability sample of over 1,400 farmers in north central wisconsin. the prevalence rate of farmer's lung disease was 4.2 per 1,000 farmers. the most prevalent antibody type was directed against micropolyspora faeni, with 6% of the study population precipitin-positive. prevalence of antibodies to m. faeni was associated with dairy farming, larger farms, and larger dairy herds. an additive effect of ... | 1981 | 7027852 |
| prevalence of precipitating antibodies to different extracts of aspergillus fumigatus in a north american asthmatic population. | this study was carried out to find the prevalence of precipitin reactions in the sera of 200 north american asthmatic subjects. precipitins were detected by the double diffusion technique using different extracts of aspergillus fumigatus, including a reference 'home produced' extract and five commercial extracts from three different suppliers. in addition, antigenicity of these extracts was assessed by crossed immunoelectrophoresis (xie). of the sera, 13.5% reacted to the reference extract and f ... | 1981 | 7028313 |
| disseminated aspergillosis treated with amphotericin b and surgery in a boy with chronic granulomatous disease. | a case of systemic infection caused by aspergillus fumigatus in a seven-year-old boy suffering from chronic granulomatous disease is described. the fungus had infiltrated his lungs, his left foot and the popliteal and inguinal lymph nodes. amphotericin b, 1 mg/kg daily, was given for three months via a central venous catheter, progressive anaemia made amputation of his left leg necessary. the bone tissue was heavily infiltrated with fungal elements. the regional lymph nodes were also resected be ... | 1980 | 7028632 |
| terelisa: the elisa test performed in terasaki plates. | the use of terasaki (10 microliter samples) and microtitration (100 microliter samples) plates as the solid phase in enzyme immunoassays was compared. various antigens were used for coating the plates and antibodies present in human sera were evaluated using the same anti-human ig antibody labelled with either beta -galactosidase, alkaline phosphatase, peroxidase or glucose oxidase. the results obtained, either by scoring with the naked eye or by absorbance reading with appropriate densitometers ... | 1981 | 7031134 |
| [negative precipitin test after surgical treatment of pulmonary and pleural aspergillosis]. | | 1981 | 7031619 |
| progressive lung disease in a malt-worker. | we described a malt-worker whose initial symptoms suggested extrinsic allergic alveolitis. the ensuing cavitating lung disease, aspergillus fumigatus infection with mycetomata, vigorous immune response, and granulomatous liver disease are unusual features. | 1981 | 7031969 |
| fungal flora in the superficial infections of the skin and nails at lucknow. | | 1981 | 7033130 |
| aspergillus keratitis with intraocular invasion. | a healthy 48-year-old man developed aspergillus keratitis following mild corneal trauma. intensive medical therapy, initially empirical, then guided by in vitro sensitivity testing, as well as attempts at surgical excision of the infection, were ultimately unsuccessful. the poor therapeutic response may have been due to fungal penetration of the deep corneal stromal before treatment was initiated. the clinical and histologic features of a keratitis are described and related to fungal keratitis i ... | 1981 | 7033854 |
| [otomycosis in the south of chile]. | | 1981 | 7034110 |
| nasal aspergillosis in three horses. | three horses were referred for investigation of a unilateral foul smelling scanty nasal discharge, complicated in one case by intermittent epistaxis. thick purulent material or a mycotic plaque was identified by an endoscopic examination of the middle meatus but in two horses this had to be repeated under general anaesthesia before the abnormalities were detected. aspergillus fumigatus was cultured from all three cases and septate hyphae were identified on smears from lesions. histological exami ... | 1981 | 7034361 |
| [the growth of thermophilic fungi strains aspergillus fumigatus and mucor lusitanicus in n-alkane medium (author's transl)]. | growth parameters of the thermophilic hydrocarbon utilizing strains aspergillus fumigatus and mucor lusitanicus in n-alkanes (kw)- and glucose (gic)-medium in standing and fermenter cultures were investigated. the temperature limits for growth were dependent on the medium composition. the temperature range for sporulation was smaller than for the hyphal growth. both strains were cultivated on carbon limitation with subsequent determinations of n-alkanes glucose, ammoniumsulfate-nitrogen, phospha ... | 1981 | 7034398 |
| [aspergillus endocarditis. report of a case treated surgically with success]. | a 42 year old man without history of rheumatic heart disease was admitted to the hospital with severe aortic insufficiency and heart failure. there were no clinical data of an infectious disease. the bidimensional echocardiogram showed vegetations involving the aortic valve leaflets. with the diagnosis of acute aortic insufficiency caused by infective endocarditis the patient was submitted to surgery. during surgery the existence of endocarditis secondary to a mycotic agent was demonstrated. the ... | 1981 | 7034662 |
| echocardiography in aspergillus endocarditis. | | 1982 | 7036080 |
| [progressive cavernous changes in the lungs after pulmonary aspergillosis]. | | 1981 | 7036103 |
| [felty syndrome and abscessing bronchopneumonia caused by aspergillus fumigatus]. | | 1981 | 7036250 |
| oxiconazole, a new imidazole derivative. evaluation of antifungal activity in vitro and in vivo. | the new imidazole derivative z-[2,4-dichloro-2-imidazol-1-yl)acetophenone]-o-(2,4-dichlorobenzyl)-oxime nitrate (oxiconazole, ro 13-8996) is characterized by a broad fungistatic spectrum against the agents of human mycoses in vitro. in addition, fungicidal activity of various degree was found in selected species (aspergillus fumigatus, cryptococcus neoformans, candida albicans and trichophyton mentagrophytes). synthesis of dna was inhibited by subinhibitory concentrations of oxiconazole in paral ... | 1982 | 7037014 |
| comparative ocular pathogenicity of cryptococcus neoformans, candida glabrata, and aspergillus fumigatus in the rabbit. | in a previous study, 88% of rabbits with disseminated infection caused by candida albicans developed ophthalmoscopically visible, hematogenous endophthalmitis (chorioretinitis) over a 2 week period. to determine the incidence of this ocular complication in disseminated infection caused by cryptococcus neoformans, candida glabrata, and aspergillus fumigatus compared with that caused by c. albicans, the first three species of fungi were injected intravenously (between 10(5) and 10(9) organisms per ... | 1982 | 7037676 |
| selective protection against conidia by mononuclear and against mycelia by polymorphonuclear phagocytes in resistance to aspergillus. observations on these two lines of defense in vivo and in vitro with human and mouse phagocytes. | by comparing natural immunity to aspergillus fumigatus (af) in vivo with the action of human or mouse phagocytes against af in vitro, we delineated two sequential lines of defense against af. the first line of defense was formed by macrophages and directed against spores. macrophages prevented germination and killed spores in vitro and rapidly eradicated conidia in vivo, even in neutropenic and athymic mice. the second was the neutrophilic granulocyte (pmn), which protected against the hyphal fo ... | 1982 | 7037853 |
| application of enzyme-linked immunosorbent assay (elisa) in diagnosis of allergic bronchopulmonary aspergillosis. | ige and igg antibodies against af were measured by elisa in sera from 15 patients with abpa and compared with antibody levels in six patients with extrinsic asthma and immediate-type skin reactivity to af (prick skin test 3+ or 4+) but no other evidence for abpa. the assay used polyvinyl microhemagglutination plates as a solid phase to adsorb antigens of af and a double-antibody system of class-specific anti-human globulin and alkaline phosphatase-conjugated goat anti-rabbit globulin. ige-af and ... | 1982 | 7038011 |
| factors influencing the production of cellulase by aspergillus fumigatus (fresenius). | during growth in liquid culture containing a single cellulosic or non-cellulosic carbon source, a newly isolated strain of aspergillus fumigatus released cellulases into the medium; the amounts produced depended on the nitrogen source, the type and concentration of the carbon source, ph and temperature. extracellular cellulolytic activity was still increasing after incubation for 60 d with 1% (w/v) cf11 cellulose, (nh4)2so4 as nitrogen source and a starting ph of 7. the activities of the new iso ... | 1981 | 7038036 |
| an indirect immunofluorescence study of antibodies to aspergillus funigatus in sera from children and adults without aspergillosis. | an indirect immunofluorescence (if) method for detection of antibodies of aspergillus fumigatus was developed: it used cryosections of formaldehyde-treated mycelium as antigen. mycelial age was found to be of importance for titer determination, and growth in czapek-dox broth for 48 h at 37 degrees c was considered optimal. fluorescein-conjugated rabbit antisera to human immunoglobulins reacted by direct if with a. fumigatus but this staining could be abolished by absorption of conjugates with ho ... | 1982 | 7038927 |
| [enzymatic studies of the thermophilic hydrocarbon utilizing fungi strains aspergillus fumigatus and mucor lusitanicus (author's transl)]. | the activities of catalase, peroxydase, and of the chitinolytic enzymes of the thermophilic hydrocarbon-utilizing fungal strains of aspergillus fumigatus and mucor lusitanicus, grown in n-alkane (kw) or glucose (glc) medium at different temperatures with additions of kcn, nano3, 3-amino-1,2,4-triazole (ata), and cacl2 and with a shift culture from glc to kw medium were determined. the enzymatic activities, able to cleave h2o2, were cytochemically shown in the hyphae with 3,3-diamino-benzidine-te ... | 1981 | 7039183 |
| multiple mycotic aneurysms and transverse myelopathy complicating repair of aortic coarctation. | the case of an 18-year-old man with coarctation of the aorta discovered on routine physical examination and subsequently surgically repaired is reported. four months postoperatively, aneurysms developed at the repair site and thrombosis of both femoral arteries was noted. following an attempt to repair the aneurysm and remove the thrombi, the patient became paraplegic; aspergillus fumigatus was found infecting the aorta and femoral vessels. after additional operations and a course of amphoterici ... | 1982 | 7039535 |
| reproducibility of prick skin tests to five allergens. | thirty-five patients had prick skin tests to the common allergens candida albicans. aspergillus fumigatus, grass pollen, horse dander and dermatophagoides pteronyssinus performed on a regular basis from autumn 1973 to autumn 1975. specific ige to the same allergens (except c. albicans) was determined at the time of skin testing for the first five seasons. it was found that the position on the volar aspect of the forearm on which the test was performed did not affect the reaction. there was a sig ... | 1982 | 7039862 |
| antigens of aspergillus fumigatus. 1. purification of a cytoplasmic antigen reactive with sera of patients with aspergillus-related disease. | an antigen has been purified from the mycelial cell sap of aspergillus fumigatus (strain 507). the same component appears to be present in the extracellular phase (culture filtrate) in a partially degraded form. the cell sap protein has a structure composed of four polypeptides of 45,000 daltons linked through disulphide bonds. the isoelectric point (5.2-5.6) and carbohydrate content (12.5% neutral hexose) indicate that this protein is an acidic glycoprotein. it shows reactions with 75% of sera ... | 1981 | 7039876 |
| hydrolysis of vegetable oils and triglycerides by thermotolerant and zoopathogenic species of aspergillus from nigerian palm produce. | the ability of aspergillus fumigatus fres. and aspergillus nidulans (eidam) wint obtained from nigerian palm produce to degrade vegetable oils and triglycerides and the production and activity of their extracellular lipases were studied. both species readily hydrolysed palm oil and palm kernel oil among others liberating free fatty acids in the process. good growth with mycelia production of both fungi were also recorded on the triglycerides used as sources of carbon at 37 degrees c with the bes ... | 1982 | 7040975 |
| isolation of 80s ribosomes from spores of aspergillus fumigatus and their antigenicity in rabbits. | ribosomes were obtained from spores of aspergillus fumigatus by mechanical disruption and differential centrifugation. the initial preparation (crude ribosomes) contained spore components which appeared to be broken fragments of plasmalemma with or without organelles. purified ribosomes free of membranous material were prepared by gel filtration chromatography on sepharose cl-4b. monomeric 80s ribosomes consisting of 40% protein and 60% rna, and morphologically characteristic of fungal ribosomes ... | 1982 | 7040976 |
| leg paralysis in pheasant poults (phasianus colchicus) due to spinal aspergillosis. | | 1981 | 7041410 |
| vaccination studies of aspergillosis in turkeys: subcutaneous inoculation with several vaccine preparations followed by aerosol challenge exposure. | five vaccines were prepared from an isolate of aspergillus fumigatus: a culture filtrate vaccine (i), a spore vaccine (ii), a mycelial vaccine (iii), and 2 germling vaccines (iv and v). the 2 germling vaccines were produced on different media. two experiments were conducted to test the vaccines for efficacy in groups of 21 turkey poults by giving each bird 2 subcutaneous inoculations of the respective vaccine at 1 and 2 weeks of age. the birds were challenge exposed to an aerosol of spores of a ... | 1982 | 7041709 |
| aspergillus fumigatus infection of the optic nerve with mycotic arteritis of cerebral vessels. | a 56-year-old caucasian male, with no obvious immune deficit or systemic disease, presented with unilateral loss of vision due to a. fumigatus infection involving the right optic nerve. there was no proptosis. despite fungal chemotherapy he developed central nervous system involvement with mycotic arteritis of the branches of the right middle cerebral artery, temporal lobe infarction and rupture of a mycotic aneurysm of the right internal carotid artery, and died. review of the literature concer ... | 1982 | 7042514 |
| [features of aspergillosis in ent. histopathology of fungal infections of the paranasal sinuses caused by aspergillus fumigatus (author's transl)]. | fungal diseases of nasal and paranasal sinuses caused by aspergillus fumigatus are not rare. second to diagnosis in defined culture medium only, histological diagnosis can easily be achieved in haematoxilin-eosin-, and pas-stained samples of fungal masses in the sinuses. specific histological features of aspergillus fumigatus are described, especially the onion-skin like structure of the fungus balls, and their development discussed. out of seventy cases only one showed invasion of the mucosa of ... | 1982 | 7042658 |
| [a case of aspergillosis involving the frontal sinus and orbit (author's transl)]. | | 1981 | 7043372 |
| [microbial sources of antigens in the environment of farmer's lung patients (author's transl)]. | the actinomycetes micropolyspora faeni and thermoactinomyces vulgaris are important sources of antigens in extrinsic allergic alveolitis, the deuteromycete aspergillus fumigatus is it to a lesser extent. these microorganisms have been sought in hay samples obtained from farmers who on the one hand show farmer's lung symptoms and on the other antibodies to these microorganisms. a relatively good correlation has been found between the immunological and microbiological findings. the conditions nece ... | 1982 | 7043907 |
| [exogenous allergic alveolitis of farmers (farmer's lung) from the viewpoint of an alpine pulmologic practice]. | extrinsic allergic alveolitis of the rural population is a relevant disease of the alpine region. observations in a pulmonologic practice suggest that the disease may represent itself in a acute and a chronic form. six patients with acute alveolitis, 8 cases of chronic farmer's lung, 16 cases of late disease stages and 33 patients of sensitization (with positive immunologic data) without overt disease are described. additional 31 patients with bronchopulmonary symptoms but without specific antib ... | 1982 | 7043910 |
| disseminated aspergillosis in a presumably immunocompetent host. | | 1982 | 7050442 |
| allergic bronchopulmonary aspergillosis: staging as an aid to management. | five stages of allergic bronchopulmonary aspergillosis were identified in 40 patients studied for several years. the stages are acute, remission, exacerbation, corticosteroid-dependent asthma, and fibrotic. the acute stage has all criteria of the disease and responds to prednisone. the remission stage is free from significant asthma or exacerbations. the exacerbation stage has recurrent flares of acute allergic bronchopulmonary aspergillosis. the corticosteroid-dependent asthma stage may have re ... | 1982 | 7059089 |
| frequency of clinical isolation and winter prevalence of different aspergillus species at a large southwestern army medical center. | the frequent occurrence of aspergillosis caused by species other than aspergillus fumigatus at brooke army medical center prompted the authors to study the prevalence of the different aspergillus species at brooke army medical center and at two other hospitals in san antonio, texas. two parameters were analyzed: (1) frequency of isolation from clinical specimens over a five-year period and (2) relative prevalence in the atmosphere during the late fall and early winter using volumetric air-sampli ... | 1982 | 7073023 |
| evaluation of indoor plantings as allergen exposure sources. | the role of indoor plantings as allergen sources was assessed by direct sampling of interior air. homes with 10 or more plants in one room and three university of michigan greenhouses were studied by means of a dc-powered rotorod and separate andersen viable sampler collections incubated at 23 degrees and 50 degrees c. sequential 30 and 60 sec andersen samples were obtained during 15 min rotorod collections before and during watering of plants as well as during disturbance of foliage by a small ... | 1982 | 7096819 |
| [aspergillus fumigatus. transverse spinal cord lesion in aspergillosis of the lung (author's transl)]. | | 1982 | 7110459 |
| optic neuropathy and paratrigeminal syndrome due to aspergillus fumigatus. | chronic aspergillus meningitis and cerebral vasculitis occurred in a 67-year-old man. he experienced periorbital pain that increased in severity during a ten-month period. although no focal neurologic deficits were initially present, oculosympathetic paresis, corneal hypesthesia, and optic neuropathy developed. this is the first report, to our knowledge, of paratrigeminal syndrome with optic neuropathy due to aspergillosis. the case was also unusual because it was chronic and there was no extrac ... | 1982 | 7115150 |
| the antifungal activity of carrier peptides, l-arginyl-x-l-phenylalanine, containing amino acid antagonists or atypical non-biogenic d-amino acids in the central position. | eleven analogues of l-arginyl-d-allo-threonyl-l-phenylalanine, a naturally occurring peptide with antifungal activity, were synthesized. two tripeptides of the form l-arginyl-x-l-phenylalanine (x = p-f-dl-phenylalanine or m-f-dl-tyrosine) inhibited aspergillus fumigatus and aspergillus flavus. in comparison with the free antagonists, the tripeptide-bound antagonists were more active against candida-albicans-isolates which means that the amino acid sequence may serve as carrier function: it enhan ... | 1982 | 7124161 |
| [a case of aspergillotic meningoencephalitis associated with trigeminal neuralgia]. | a case of aspergillotic meningoencephalitis associated with trigeminal neuralgia was reported. the patient, a 41-year-old female, was admitted to our hospital on nov. 20, 1977 with the chief complaint of right trigeminal neuralgia. on admission right facial paresthesia and right abducens palsy were found. the skull x-ray and tomogram showed enlargement of the right superior orbital fissure. ct scan revealed an irregular high density around the right superior orbital fissure. the examination of s ... | 1982 | 7133307 |
| amino acid sequence homologies in alfa-sarcin, restrictocin and mitogillin. | | 1982 | 7150290 |
| [antifungal agents in otorhinolaryngology]. | numerous progresses are realized in the chemotherapy of mycoses, particularly in the field of deep mycoses due to 3 categories of systemic antifungal agents: polyenes (oral nystatin, oral and intravenous amphotericin b), 5-fluorocytosine (oral and intravenous) and imidazole derivatives (oral and intravenous miconazole, oral ketoconazole). the old drugs as nystatin and amphotericin b per os continue to have a remarkable effect in oro-pharyngeal candidosis, chiefly after sufficient local contact w ... | 1982 | 7158918 |
| microbial aerosols and actinomycetes in etiological considerations of mushroom workers' lungs. | spent steamed compost, phase ii compost, and dust emanating from spent compost during dumping of stationary-bed mushroom houses were examined bacteriologically. the total count for spent compost was 16 x 10(8) microorganisms per g. the total count for dust was 333 microorganisms per liter of air. actinomycetes belonging to the genus streptomyces often constituted 90% or more of isolates from dust, whereas mold spores constituted approximately 5%. dust weight averaged 3.4 mg/liter of air and cont ... | 1981 | 7195685 |
| the microbiology of spent mushroom compost and its dust. | microorganisms in spent steamed mushroom compost and its dust were enumerated, and identified. some phase ii (indoor composting) compost samples were also examined. steaming of spent compost resulted in a 70-76% reduction in microbial numbers. total counts made with compost fusion agar were approximately two logs greater than those for nutrient agar. the most common bacterial isolate was bacillus licheniformis. the most common actinomycete isolates were streptomyces diastaticus and thermoactinom ... | 1981 | 7197578 |
| the prevalence of immediate positive skin tests in nepalese children. | two hundred and ninety-three normal schoolchildren between 5 and 15 years old living in the hills of eastern nepal were tested by the skin prick method for sensitivity to six allergens: dermatophagoides pteronyssinus, aspergillus fumigatus. cladosporium herbarum, penicillium notatum, mixed pollens and mixed threshings. these children were also questioned and examined for symptoms and signs relating to allergic disease. of the children, 20% were skin-prick positive to at least one of the allergen ... | 1981 | 7249341 |
| allergic bronchopulmonary aspergillosis in corticosteroid-dependent asthmatics. | forty-two corticosteroid-dependent asthmatics were studied to determine whether their underlying disease might be allergic bronchopulmonary aspergillosis (abpa). the clinical and laboratory characteristics studied included age, sex, atopic status, mean corticosteroid doses, skin tests to aspergillus fumigatus (af), precipitins to af, total serum ige, and chest roentgenograms. twelve patients had four or more of the seven primary criteria used and were considered as the abpa suspect group. furthe ... | 1981 | 7252001 |
| 125i-clq-binding and specific antibodies as indicators of pulmonary disease activity in cystic fibrosis. | we studied the incidence and levels of circulating immune complexes by the 125i-clq-binding assay in patients with cystic fibrosis in relation to clinical respiratory status and specific igg and ige antibodies to pseudomonas aeruginosa. staphylococcus aureus, aspergillus fumigatus, and candida albicans. overall prevalence of cic was 43%, but 86% of serially studied patients had evidence of cic at some time. patients with acute respiratory exacerbations and deteriorating pulmonary function had a ... | 1981 | 7252678 |
| porcine abortions associated with fungi, actinomycetes, and rhodococcus sp. | history, lesions, and results of microbiologic examinations are given for four porcine abortions associated with fungi and one each associated with actinomadura madurae, an aerobic actinomycete, and rhodococcus sp. the fungi were gliomastix sp., petriellidium boydii, aspergillus fumigatus, and exophiala jeanselmei. parvovirus, isolated from one fetus, was the only other infectious agent identified. the presence of fungi, actinomadura madurae, and rhodococcus sp. in fetal and placental lesions in ... | 1981 | 7281459 |
| the effect of 5-fluorocytosine on the synthesis of 80s ribosomes by pathogenic fungi. | we studied the influence of 5-fluorocytosine(5fc) on the monomeric 80s ribosomes isolated by gradient ultracentrifugation from candida albicans, cryptococcus neoformans, aspergillus fumigatus and wangiella dermatitidis. labelling of the cultures with 32po4 and [3h]-leucine showed marked inhibition of both ribosomal rna and ribosomal protein synthesized during the contact of the fungi with the drug. the degree of inhibition was very similar for the synthesis of both ribosomal constituents, (mostl ... | 1981 | 7292207 |
| synthesis and in vitro antimicrobial property of o-carborane derivatives. | various o-carboranes and nido-type dicarbollide anions have been synthesized and tested for antimicrobial activity. nearly all of the dicarbollide monoanions investigated were active in vitro against fungi such as candida albicans, aspergillus fumigatus, and tricophyton asteroides, as well as against gram-positive bacteria. from a consideration of the structure-activity relationships, it seems most reasonable to conclude that the introduction of lipophilic alkyl or o-carboranyl groups to the hyd ... | 1981 | 7310826 |
| the effect of bacterial and fungal phospholipids on the activity of macrophages. | the effect of some bacterial and fungal phospholipids on the functions of macrophage in mice was studied. it has been found that in animals injected with phospholipids from staphylococcus aureus, streptococcus faecalis, bacillus subtilis and aspergillus fumigatus the population of macrophages with increased phagocytic and microbicidal activity appeared. the phospholipids from cryptococcus neoformans and penicillium notatum did not affect the activity of macrophages. administration of the candida ... | 1981 | 7347586 |
| experimental aspergillosis in rabbits. | controls, as well as cortisone-treated rabbits, were challenged with aspergillus fumigatus spores intratracheally. animals were sacrificed 3, 7, 14 and 28 days after inoculation and their organs cultured and studied histologically. lesions were produced in both groups, although the cortisone-treated group showed greater pathology and the lesions persisted for a longer period of time than the control groups. histologically, the pulmonary lesions showed granulomatous pulmonary aspergillosis and su ... | 1981 | 7348209 |
| antigenemia detected by radioimmunoassay in systemic aspergillosis. | because of difficulties in antemortem diagnosis of systemic aspergillosis, a radioimmunoassay to an aspergillus fumigatus carbohydrate was developed and evaluated in patients with mycotic or bacterial infections. antigenemia was detected in sera obtained antemortem from four of seven patients with systemic aspergillosis and in pleural fluid from an aspergillus empyema but not in control sera or pleural fluid from 43 patients or 27 normal donors. when characterized with reference to onset of dise ... | 1980 | 7387020 |
| hla-a, b and c and hla-dr antigens in intrinsic and allergic asthma. | some 103 patients with asthma and 100 healthy volunteers have been typed for hla-a, b and c and hla-dr antigens. the 103 patients consisted of thirty-three with intrinsic asthma, thirty-four with extrinsic asthma, and thirty-six known to have precipitins to aspergillus fumigatus. no increase in frequency of any of the a, b, c, or dr antigens was found to be significant after correction for the number of comparisons was made. however certain trends comparable to findings in other immunopathic dis ... | 1980 | 7389070 |
| fatal pulmonary psittacosis and aspergillosis. case report of dual infection. | a 59-year-old man in previously good health had acute, progressive bronchopneumonia and died after a three-week course of illness, despite treatment with various antibiotics. serologic, microbiologic, and histologic findings indicated infection with both chlamydia psittaci and aspergillus fumigatus. disseminated, invasive aspergillosis sometimes is a complication of chronic respiratory disease, malignancy, or other deficiency of host defenses, but to our knowledge, this is the first report of ps ... | 1980 | 7396594 |
| invasive pulmonary aspergillosis in an apparently nonimmunocompromised host. | invasive aspergillosis generally occurs in patients with hematologic malignancies, neutropenia or other severe derangements of host defense. an adult patient without such a predisposition, and without a previous history of susceptibility to infections, had rapidly progressive respiratory failure associated with repeated growth of aspergillus fumigatus on culture of sputum and bronchoscopy specimens. at autopsy he proved to have invasive pulmonary aspergillosis. | 1980 | 7424951 |
| cerebral aspergilloma in a patient with allergic bronchopulmonary aspergillosis. | the case is described of a woman of 21 who had suffered since childhood from asthma and allergic bronchopulmonary aspergillosis. during her recovery from a period of severe status asthmaticus she developed widespread patchy lung shadowing, signs of an intracerebral space-occupying lesion and high titres of serum precipitins to aspergillus fumigatus. post-mortem examination revealed aspergillus bronchopneumonia and an intracerebral aspergilloma. | 1980 | 7426370 |
| solubilization of insoluble phosphates by thermophilic fungi. | the solubilization of tricalcium phosphate and rock phosphate and assimilation of solubilized p by thermophilic fungi isolated from compost were studied. the solubilization of tricalcium phosphate was greater than that of rock phosphate on inoculation with fungi in liquid medium, but growth of most of the fungi was greater in rock phosphate. torula thermophila solubilized tricalcium phosphate maximally. there was solubilization of rock phosphate in semi-solid lignocellulose medium by aspergillus ... | 1980 | 7469257 |
| [allergic alveolitis following inhalation of mould spores from pot plant earth (author's transl)]. | acute exogenous allergic alveolitis with the typical symptoms of unproductive cough, dyspnoea on exertion, fever, loss of weight, headache and limb pains was observed in a 24-year-old bank employee. leucocytosis was accompanied by raised esr; pronounced hypoxaemia and marked restrictive ventilatory defects were found. x-ray changes consisted of severely increased fine reticular interstitial shadowing. the differential diagnosis of allergic alveolitis was confirmed by the demonstration of precipi ... | 1981 | 7472183 |
| aspergillus peritonitis in peritoneal dialysis: case report and a review of the literature. | aspergillus peritonitis is a rare complication of continuous ambulatory peritoneal dialysis. the case is described of a 68-year-old man in whom aspergillus fumigatus was isolated from the peritoneal dialysate after recurrent peritonitis with gram-negative rods in association with diverticulosis. treatment consisting of removal of the catheter and intravenous administration of amphotericin b followed by oral itraconazole was successful. a review of the sparse literature (12 cases) displays uncert ... | 1995 | 7478133 |
| [cavitary pneumonia in a neutropenic patient]. | | 1995 | 7481013 |
| aerosol and parenteral pneumocandins are effective in a rat model of pulmonary aspergillosis. | the pneumocandins are semisynthetic analogs of echinocandin-like compounds that have shown efficacy in animal models of systemic candidiasis, disseminated aspergillosis, and pneumocystis pneumonia. however, the most common form of aspergillus infection in susceptible patients is pulmonary aspergillosis, which was not directly tested in the mouse models used in the past. we have evaluated three pneumocandins, l-693,989, l-731,373, and l-733,560, in a rat model of pulmonary aspergillosis. male spr ... | 1995 | 7486919 |
| efficacy of d0870 compared with those of itraconazole and amphotericin b in two murine models of invasive aspergillosis. | d0870 is a novel azole antifungal compound. it was compared with conventional amphotericin b and itraconazole therapy in two murine models of invasive aspergillosis, one a systemic nonimmunocompromised mouse model and the other a temporarily neutropenic mouse respiratory model. d0870 was given orally and achieved measurable concentrations in serum approximately proportional to the daily dose with accumulation over time if it was given twice daily. amphotericin b at 3.3 mg/kg of body weight was g ... | 1995 | 7486923 |
| cloning and characterization of the cdnas and genes (mep20) encoding homologous metalloproteinases from aspergillus flavus and a. fumigatus. | aspergillus fumigatus (afu) and a. flavus (afl), two causative agents of invasive aspergillosis, produce highly homologous serine proteinases. in addition, the former produces a 42-kda metalloproteinase (mep), whereas the latter produces a 23-kda mep. the cdna and the gene encoding the 42-kda mep were cloned and sequenced. here, we report the cloning of the cdna and the gene encoding the 23-kda mep from afl and a homologous gene from the afu. using degenerate primers based on the amino acid (aa) ... | 1995 | 7489900 |
| in vitro and in vivo antifungal activities of du-6859a, a fluoroquinolone, in combination with amphotericin b and fluconazole against pathogenic fungi. | du-6859a is an investigational fluoroquinolone agent with potent bactericidal activity, but by itself it has no antifungal activity. when combined with amphotericin b (amb), however, du-6859a clearly enhanced the in vitro antifungal activity of amb against candida albicans, candida tropicalis, candida krusei, candida glabrata, and cryptococcus neoformans in microdilution checkerboard studies. positive interactions of du-6859a with amb against aspergillus fumigatus were dependent on the medium us ... | 1995 | 7492096 |
| ige binding to a human profilin-containing fraction caused by contamination with yeast-derived material. | | 1995 | 7499689 |
| diagnostic value of recombinant aspergillus fumigatus allergen i/a for skin testing and serology. | we report a clinical study comparing the recombinant aspergillus fumigatus allergen i/a (rasp f i/a) to two commercial a. fumigatus extracts in skin prick tests, intradermal tests, and serologic assays. | 1994 | 7508461 |
| [pleuropulmonary aspergillosis with defective neutrophil functions--g-csf effects on neutrophil functions]. | a 66-year-old man was admitted to our hospital with productive cough and fever. chest x-ray films showed pleural thickening of the right apex and calcification of the lung field. antibiotic therapy was administered but no improvement was obtained. chest ct scan revealed pleural thickening with effusion in the right apex. needle aspiration biopsy was performed and aspergillus fumigatus was isolated from pleural fluid. we began pleural drainage and intrapleural infusion of miconazole, with systemi ... | 1994 | 7509423 |