| zika virus spreading in south america: evolutionary analysis of emerging neutralizing resistant phe279ser strains. | to investigate the genetic diversity of zika virus (zikv) and the relationships existing among these circulating viruses worldwide. to evaluate the genetic polymorphisms harbored from zikv that can have an influence on the virus circulation. | 2016 | 27261852 |
| the clinical spectrum of zika virus in returning travelers. | the clinical spectrum of zika virus had, to date, been described in small series from endemic/epidemic countries and is not well established. | 2016 | 27260832 |
| ethnobotanical knowledge on botanical repellents employed in the african region against mosquito vectors - a review. | mosquitoes (diptera: culicidae) represent a huge threat for millions of humans and animals worldwide, since they act as vectors for important parasites and pathogens, including malaria, filariasis and important arboviruses, such as dengue, west nile and zika virus. no vaccines or other specific treatments are available against the arboviruses transmitted by mosquitoes, and avoidance of mosquito bites remains the best strategy. african regions are usually hit most whose inhabitants are poor, and ... | 2016 | 27260568 |
| zika virus infection and development of a murine model. | in view of the recent outbreak of zika virus (zikv), there is an urgent need to investigate the pathogenesis of the symptoms associated with zikv infection. since the first identification of the virus in 1947, the pathologies associated with zikv infection were thought to be limited with mild illness that presented fever, rashes, muscle aches, and weakness. however, zikv infection has been shown to cause guillain-barré syndrome, and numerous cases of congenital microcephaly in children have been ... | 2016 | 27260223 |
| dengue, chikungunya … and the missing entity - zika fever: a new emerging threat. | zika virus (zikv), a relative newcomer from the flavivirus group that includes dengue, japanese encepahalitis and yellow fever, is one of the emerging pathogens that is fast transcending geographical boundaries. it is a vector-borne disease transmitted by the same aedes aegypti and aedes albopictus, which cause dengue and chikungunya. in addition to the vector-mediated transmission of zika fever, probable human-to-human transmission through exchange of body fluids, including sexual and perinatal ... | 2016 | 27257326 |
| [investigation on the preventive and control strategies against the first imported case of zika virus infection in china mainland]. | | 2016 | 27256738 |
| neurodevelopmental disorders: zika virus causes brain defects in mice. | | 2016 | 27256555 |
| surveillance snapshot: zika virus infection among military health system beneficiaries following introduction of the virus into the western hemisphere, 20 may 2016. | | 2016 | 27255948 |
| zika virus: oral health care and oral disease. | | 2017 | 27255682 |
| zika virus infection: an emerging disease the dermatologist must know about. | | 2016 | 27255550 |
| engineering paper-based sensors for zika virus. | the emergence of zika virus (zikv) infections in latin america and southeast asia has created an urgent need for new, simple, yet sensitive, diagnostic tests. we highlight recent work using paper-based sensors coupled with crispr/cas9 to detect zikv rna as a new approach to achieve rapid development and deployment of field-ready diagnostics for emerging infectious diseases. | 2016 | 27255410 |
| zika virus, microcephaly, and ocular findings. | | 2016 | 27254835 |
| letter to the editor: specificity of zika virus elisa: interference with malaria. | | 2016 | 27254259 |
| zika virus, microcephaly, and ocular findings-reply. | | 2016 | 27253432 |
| zika virus, microcephaly, and ocular findings-reply. | | 2016 | 27253365 |
| zika virus, microcephaly, and ocular findings. | | 2016 | 27253205 |
| zika virus infection and surgery: what should we be concerned about? | | 2016 | 27249094 |
| possible zika virus infection among pregnant women - united states and territories, may 2016. | zika virus is a cause of microcephaly and brain abnormalities (1), and it is the first known mosquito-borne infection to cause congenital anomalies in humans. the establishment of a comprehensive surveillance system to monitor pregnant women with zika virus infection will provide data to further elucidate the full range of potential outcomes for fetuses and infants of mothers with asymptomatic and symptomatic zika virus infection during pregnancy. in february 2016, zika virus disease and congeni ... | 2016 | 27248295 |
| zika virus infects human placental macrophages. | the recent zika virus (zikv) outbreak in brazil has been directly linked to increased cases of microcephaly in newborns. current evidence indicates that zikv is transmitted vertically from mother to fetus. however, the mechanism of intrauterine transmission and the cell types involved remain unknown. we demonstrate that the contemporary zikv strain prvabc59 (pr 2015) infects and replicates in primary human placental macrophages, called hofbauer cells, and to a lesser extent in cytotrophoblasts, ... | 2016 | 27247001 |
| zika virus: what clinicians need to know. | | 2016 | 27236867 |
| zika virus infection: current concerns and perspectives. | the zika virus outbreaks highlight the growing importance need for a reliable, specific and rapid diagnostic device to detect zika virus, as it is often recognized as a mild disease without being identified. many zika virus infection cases have been misdiagnosed or underreported because of the non-specific clinical presentation. the aim of this review was to provide a critical and comprehensive overview of the published peer-reviewed evidence related to clinical presentations, various diagnostic ... | 2016 | 27236440 |
| expanded spectrum of congenital ocular findings in microcephaly with presumed zika infection. | to describe the ocular findings of 3 cases of suspected congenital zika viral infection with microcephaly and maculopathy. | 2016 | 27236271 |
| nucleoside inhibitors of zika virus. | there is growing evidence that zika virus (zikv) can cause devastating infant brain defects and other neurological disorders in humans. however, no specific antiviral therapy is available at present. we tested a series of 2'-c- or 2'-o-methyl-substituted nucleosides, 2'-c-fluoro-2'-c-methyl-substituted nucleosides, 3'-o-methyl-substituted nucleosides, 3'-deoxynucleosides, derivatives with 4'-c-azido substitution, heterobase-modified nucleosides, and neplanocins for their ability to inhibit zikv ... | 2016 | 27234417 |
| challenges of zika virus infection in pregnant women. | | 2016 | 27232529 |
| zika virus: oral healthcare implications. | zika virus (zikv) infection has been recognised since 1947, but just recently it became a worldwide major public health problem. the most common features of zikv infection are fever, cutaneous rash, arthralgia and conjunctivitis but most affected patients with the clinical disease present with only mild symptoms. however, severe neurological complications have been described: there is an occasional association with guillain-barre syndrome, and emerging data indicate an association between vertic ... | 2017 | 27232461 |
| cns infections: mouse studies confirm the link between zika virus infection and microcephaly. | | 2016 | 27231186 |
| [guillain-barré syndrome following infection with the zika virus]. | guillain-barré syndrome (gbs) has been identified as a possible complication of infections with the zika virus (zikv) in the current epidemic in central and south america. here we describe the first case of gbs in the netherlands following a zikv infection. | 2016 | 27229696 |
| risk factors associated with the ophthalmoscopic findings identified in infants with presumed zika virus congenital infection. | the zika virus (zikv) might cause microcephaly and ophthalmoscopic findings in infants of mothers infected during pregnancy. | 2016 | 27228275 |
| guillain-barré syndrome and zika virus: estimating attributable risk to inform intensive care capacity preparedness. | | 2016 | 27225243 |
| public health: use open data to curb zika virus. | | 2016 | 27225109 |
| public health acts to detect, respond to, and prevent the latest public health threat-zika virus disease. | | 2016 | 27223315 |
| of mosquito nets and condoms: the zika virus challenge. | | 2016 | 27223311 |
| zika virus infection spread through saliva. | | 2016 | 27223135 |
| zika virus infection: control and prevention. | | 2016 | 27221543 |
| zika virus: two or three lineages? | zika virus (zikv) infection has become an emerging concern of global public health. several recent studies provide new insights into the evolution and diversity of zikv, with important implications for ongoing surveillance and control measures. | 2016 | 27220937 |
| zika prep. 5 things you should know about zika. | the migration of the zika virus into north america is posing challenges for health care providers. here are five things to keep in mind. | 2016 | 27220167 |
| zika virus infection, a new public health challenge. | | 2017 | 27215946 |
| correction: characterization of lethal zika virus infection in ag129 mice. | [this corrects the article doi: 10.1371/journal.pntd.0004682.]. | 2016 | 27214379 |
| viral pathogenesis: tracing the steps of zika virus. | | 2016 | 27211788 |
| who interim guidance on pregnancy management in the context of zika virus infection. | | 2016 | 27211476 |
| zika virus, vectors, reservoirs, amplifying hosts, and their potential to spread worldwide: what we know and what we should investigate urgently. | the widespread epidemic of zika virus infection in south and central america and the caribbean in 2015, along with the increased incidence of microcephaly in fetuses born to mothers infected with zika virus and the potential for worldwide spread, indicate the need to review the current literature regarding vectors, reservoirs, and amplification hosts. | 2016 | 27208633 |
| zika virus update ii: recent development of animal models-proofs of association with human pathogenesis. | three recent studies in pregnant mice and one ongoing study in rhesus macaques evaluating the effect of zikv infection have provided important information about maternal-fetus transmission and zikv-related pathogenesis, confirming a causal role of zikv in neurological problems observed in humans. here, we present an update of these works published in the past few weeks. j. med. virol. 88:1657-1658, 2016. © 2016 wiley periodicals, inc. | 2016 | 27208545 |
| who warns of risk of zika virus in europe. | | 2016 | 27207768 |
| placenta, zika virus infection and fetal brain abnormality. | | 2016 | 27207189 |
| understanding the pathogenic evolution of zika virus. | | 2016 | 27207138 |
| alternative vector control methods to manage the zika virus outbreak: more haste, less speed - authors' reply. | | 2016 | 27198838 |
| alternative vector control methods to manage the zika virus outbreak: more haste, less speed. | | 2016 | 27198837 |
| alternative vector control methods to manage the zika virus outbreak: more haste, less speed. | | 2016 | 27198836 |
| an infectious cdna clone of zika virus to study viral virulence, mosquito transmission, and antiviral inhibitors. | the asian lineage of zika virus (zikv) has recently caused epidemics and severe disease. unraveling the mechanisms causing increased viral transmissibility and disease severity requires experimental systems. we report an infectious cdna clone of zikv that was generated using a clinical isolate of the asian lineage. the cdna clone-derived rna is infectious in cells, generating recombinant zikv. the recombinant virus is virulent in established zikv mouse models, leading to neurological signs relev ... | 2016 | 27198478 |
| the zika epidemics and transplantation. | in the last few months an epidemic of zika virus (zikv) has affected several countries, and it continues to spread rapidly. this virus was initially thought to cause only a mild febrile illness; however, the current epidemic has shown that it is associated with serious complications. increasing reports are linking zikv to devastating conditions such as microcephaly in newborns and important neurologic syndromes. although zikv infection has not yet been reported in transplant recipients, it is li ... | 2016 | 27197772 |
| [zika, a neurotropic virus?]. | in this paper, the neurotropism potential zika virus is discussed, by comparison with viruses both rna and dna are neurotropic known, also it is said that compared with the new viruses that have affected the americas, as the chikungunya, zika has shown great affinity by brain tissue, manifested by a high incidence of acute neurological conditions, such as guillain-barré syndrome, among others, as well as the reported incidence of microcephaly that is abnormally high compared with the previous in ... | 2016 | 27197113 |
| zika virus: a re-emerging pathogen with rapidly evolving public health implications. | | 2016 | 27196545 |
| zika virus and microcephaly: is the correlation causal or coincidental? | | 2016 | 27196544 |
| clinical and imaging findings in an infant with zika embryopathy. | recent zika virus (zikv) outbreaks have been associated with an increased incidence of neonatal microcephaly. subsequently, tropism for the brain was established in human fetal brain tissue. we present the first congenital zikv infection in the united states, confirmed by high zikv immunoglobulin m antibody titers in serum and cerebrospinal fluid. the phenotypic characteristics of the patient fall within fetal brain disruption sequence, suggesting impaired brain development in the second half of ... | 2016 | 27193747 |
| zika virus and women. | | 2016 | 27192024 |
| [infestation status aedes albopictus and related mosquito-borne infectious disease risk in central urban area in shanghai]. | to evaluate aedes albopictus infestation status in the central urban area of shanghai, and analyze the related epidemic risk of mosquito-borne infectious disease. | 2016 | 27188346 |
| [survey of the third zika virus disease case in the mainland of china]. | to evaluate the performance of zika virus(zikv)disease prevention and control. | 2016 | 27188345 |
| [survey of the first case of zika virus disease in the mainland of china]. | to analyze epidemiological characteristics of the first laboratory confirmed case of zika virus disease in the mainland china, and provide evidence for the prevention and control of the spread of zika virus disease. | 2016 | 27188344 |
| zika virus and glut1. | | 2016 | 27184421 |
| excretion of infectious zika virus in urine. | | 2016 | 27184420 |
| zika virus infection during pregnancy in mice causes placental damage and fetal demise. | zika virus (zikv) infection in pregnant women causes intrauterine growth restriction, spontaneous abortion, and microcephaly. here, we describe two mouse models of placental and fetal disease associated with in utero transmission of zikv. female mice lacking type i interferon signaling (ifnar1(-/-)) crossed to wild-type (wt) males produced heterozygous fetuses resembling the immune status of human fetuses. maternal inoculation at embryonic day 6.5 (e6.5) or e7.5 resulted in fetal demise that was ... | 2016 | 27180225 |
| zika crisis in brazil: challenges in research and development. | infection with the zika virus (zikv) usually causes a mild acute illness, but two major severe syndromes have been described during the epidemic in brazil: microcephaly and the guillain-barré syndrome. there is now much evidence to show that zikv can infect and damage neuronal cells in vitro. in experimental animals, zikv has significant neurotropism and can cause brain damage. at present, diagnosis is still a challenge in the field and there is no treatment available. another major challenge is ... | 2016 | 27179929 |
| zika virus disrupts neural progenitor development and leads to microcephaly in mice. | the link between zika virus (zikv) infection and microcephaly has raised urgent global alarm. the historical african zikv mr766 was recently shown to infect cultured human neural precursor cells (npcs), but unlike the contemporary zikv strains, it is not believed to cause microcephaly. here we investigated whether the asian zikv strain sz01 could infect npcs in vivo and affect brain development. we found that sz01 replicates efficiently in embryonic mouse brain by directly targeting different ne ... | 2016 | 27179424 |
| zika virus in saliva-new challenges for prevention of human to human transmission. | | 2016 | 27179414 |
| zika virus at the games: is it safe? | | 2016 | 27177718 |
| zika virus: new emergencies, potential for severe complications, and prevention of transfusion-transmitted zika fever in the context of co-circulation of arboviruses. | | 2016 | 27177409 |
| don't curb your enthusiasm. | the texas department of state health services commissioner john hellerstedt, md, talks about his assessment of the state health department, how medicine can help the agency achieve its public health mission, and the challenges involved in zika virus. | 2016 | 27175927 |
| cdc updates interim guidance on caring for women with possible exposure to zika virus. | | 2016 | 27175724 |
| [global spread of zika virus epidemic: current knowledges and uncertainties]. | zika virus (zikv) is an enveloped rna virus that belongs to the flaviviridae family. although more than 60 years have passed since the discovery and first reported human cases of the virus, only a small number (< 10) of cases had been encountered in the literature until the last 10 years. zika virus was known as a virus which caused sporadic infections and was confined to africa and asia along a narrow equatorial line. in 2007, however, the first major outbreak of zikv occurred in yap island (mi ... | 2016 | 27175508 |
| reply to comments on "zika virus transmission: what to concern on its transmission apart from mosquito control" by viroj wiwanitkit. | | 2016 | 27174386 |
| restriction of zika virus by host innate immunity. | recent epidemics of zika virus (zikv) have brought increasing concerns of heightened disease severity and neurotropism. in this issue of cell host & microbe, lazear et al. (2016) and bayer et al. (2016) show that innate immunity can restrict zikv infection and disease development. | 2016 | 27173920 |
| erratum: vol. 65, no. 18. | in the report, "interim guidance for zika virus testing of urine - united states, 2016," the second sentence of the second paragraph should have read, "zika virus rrt-pcr testing of urine should be performed in conjunction with serum testing (8)." the report was first published online as an early release on may 10, 2016, and is now contained in this regular may 13 issue. | 2016 | 27171972 |
| comparison of test results for zika virus rna in urine, serum, and saliva specimens from persons with travel-associated zika virus disease - florida, 2016. | in may 2015, zika virus was reported to be circulating in brazil. this was the first identified introduction of the virus in the region of the americas. since that time, zika virus has rapidly spread throughout the region. as of april 20, 2016, the florida department of health bureau of public health laboratories (bphl) has tested specimens from 913 persons who met state criteria for zika virus testing. among these 913 persons, 91 met confirmed or probable zika virus disease case criteria and al ... | 2016 | 27171533 |
| interim guidance for zika virus testing of urine - united states, 2016. | diagnostic testing for zika virus infection can be accomplished using molecular and serologic methods. real-time reverse transcription-polymerase chain reaction (rrt-pcr) is the preferred test for zika virus infection because it can be performed rapidly and is highly specific (1,2). however, in most patients, zika virus rna is unlikely to be detected in serum after the first week of illness (2,3). recent reports using adaptations of previously published methods (2,4) suggest that zika virus rna ... | 2016 | 27171368 |
| experimental studies of susceptibility of italian aedes albopictus to zika virus. | we report a study on vector competence of an italian population of aedes albopictus for zika virus (zikv). ae. albopictus was susceptible to zikv infection (infection rate: 10%), and the virus could disseminate and was secreted in the mosquito's saliva (dissemination rate: 29%; transmission rate: 29%) after an extrinsic incubation period of 11 days. the observed vector competence was lower than that of an ae. aegypti colony tested in parallel. | 2016 | 27171034 |
| zika virus: an emerging infectious threat. | | 2016 | 27170237 |
| mucocutaneous findings and course in an adult with zika virus infection. | the zika virus epidemic has been declared a public health emergency of international concern by the world health organization. we describe the mucocutaneous features and histologic correlation in a patient with the acute zika virus infection. | 2016 | 27168495 |
| [zika virus outbreak in latin america: what are the challenges for french guiana in april 2016?]. | started in 2015 in brazil, an outbreak linked to a little known arbovirus, zika virus spread throughout latin america. this virus, considered until recently as responsible of only mild symptoms, made mention of previously unsuspected complications, with severe neurological manifestations in adults and malformations of the central nervous system, including microcephaly, in newborns of mother infected during the pregnancy. while the continent is more accustomed to the succession of arbovirus epide ... | 2016 | 27167975 |
| zika virus infection and pregnancy. | | 2016 | 27167538 |
| update on zika virus infection in pregnancy. | | 2016 | 27167537 |
| zika virus in the americas: an obscure arbovirus comes calling. | | 2016 | 27167249 |
| zika virus. | | 2016 | 27166755 |
| effects of zika virus. | | 2016 | 27165390 |
| zika virus-associated guillain-barré syndrome variant in haiti. | | 2016 | 27164708 |
| zika virus pandemic: a human and public health crisis. | | 2016 | 27163559 |
| zika virus depletes neural progenitors in human cerebral organoids through activation of the innate immune receptor tlr3. | emerging evidence from the current outbreak of zika virus (zikv) indicates a strong causal link between zika and microcephaly. to investigate how zikv infection leads to microcephaly, we used human embryonic stem cell-derived cerebral organoids to recapitulate early stage, first trimester fetal brain development. here we show that a prototype strain of zikv, mr766, efficiently infects organoids and causes a decrease in overall organoid size that correlates with the kinetics of viral copy number. ... | 2016 | 27162029 |
| an emerging cause of concern in europe: zika virus, the developing cns and the pediatric neurologist. | | 2016 | 27160366 |
| zika virus - emergence, evolution, pathology, diagnosis, and control: current global scenario and future perspectives - a comprehensive review. | this review converses the zika virus which has attained global concern due to its rapid pandemic potential and impact on humans. though zika virus was first isolated in 1947, till the recent large-scale outbreak which occurred in micronesia, in 2007, the virus was placed into the innocuous pathogen category. the world health organization on 1 february 2016 declared it as a 'public health emergency of international concern.' of the note, american as well as pacific island strains/isolates is rela ... | 2016 | 27158761 |
| structures of the zika virus envelope protein and its complex with a flavivirus broadly protective antibody. | zika virus (zikv), a mosquito-borne flavivirus, is a current global public health concern. the flavivirus envelope (e) glycoprotein is responsible for virus entry and represents a major target of neutralizing antibodies for other flaviviruses. here, we report the structures of zikv e protein at 2.0 å and in complex with a flavivirus broadly neutralizing murine antibody 2a10g6 at 3.0 å. zikv-e resembles all the known flavivirus e structures but contains a unique, positively charged patch adjacent ... | 2016 | 27158114 |
| zika virus: what do emergency physicians need to know? | zika virus currently dominates headlines, creating public fear due to its complications. with the ease of worldwide travel, this disease has spread rapidly to the u.s. | 2016 | 27157106 |
| genomic characterization and phylogenetic analysis of zika virus circulating in the americas. | the rapid spread and potential link with birth defects have made zika virus (zikv) a global public health problem. the virus was discovered 70years ago, yet the knowledge about its genomic structure and the genetic variations associated with current zikv explosive epidemics remains not fully understood. in this review, the genome organization, especially conserved terminal structures of zikv genome were characterized and compared with other mosquito-borne flaviviruses. it is suggested that major ... | 2016 | 27156653 |
| [zika virus infection or the future of infectious diseases]. | zika virus belongs to the flaviridae, an extended phylogenetic family containing dengue or yellow fever, viruses whose shared main vector are aedes aegypti mosquitoes. the virus originally came from central african simian reservoirs and, from there, expanded rapidly across the pacific to south america. the disease is an example of exantematic fever usually mild. mortality is very low and mainly limited to secondary guillain-barré or fetal microcephaly cases. diagnostic confirmation requires a rt ... | 2016 | 27156484 |
| hormonal contraceptive prescriptions in colombia and zika virus. | | 2016 | 27156436 |
| zika virus: a new challenge for blood transfusion. | | 2016 | 27156435 |
| travellers warned about zika virus. | nhs staff working in primary care have been advised to take a more precautionary approach to the zika virus, particularly with pregnant women. | 2016 | 27156408 |
| understanding how zika virus enters and infects neural target cells. | zika virus is a mosquito-transmitted flavivirus that has become a public health concern because of its ability to cause microcephaly. in this issue of cell stem cell, tang et al. (2016) and nowakowski et al. (2016) use human neural stem cell models and single-cell rna sequencing to investigate zika virus tropism and potential entry receptors. | 2016 | 27152436 |
| zika virus in pregnancy: where to find useful guidance. | | 2016 | 27151369 |
| the zika virus epidemic: professionals and the public search for answers. | | 2016 | 27151254 |
| zika virus and microcephaly - more questions than answers? | | 2016 | 27150736 |
| microcephaly associated with maternal zika virus infection. | | 2016 | 27150580 |