| hyperlipidemia, hypercoagulability, and accelerated thrombosis: studies in congenitally hyperlipidemic rats and in rats and monkeys with induced hyperlipidemia. | inbred carworth farms nelson (cfn) congenitally hyperlipidemic rats had significantly shorter coagulation and prothrombin times and higher levels of coagulation factors, ii, v, vii, viii, and x than did controls. conversely, congenitally hypolipidemic rats of the same strain had significantly longer coagulation and prothrombin times and lower levels of factors ii, v, vii, x and xii and of blood platelets than did controls. a loop-shaped polyethylene cannula was inserted into the aorta to assess ... | 1976 | 812575 |
| cortical blindness after overlapping retinal-striate lesions: a limit to plasticity in the central visual system. | lesions in cats, rats, and monkeys that spare more than 2% of the optic tract or visual cortex cause trivial deficits on most measures of vision. overlap in the topography of the visual system may allow the spared remnant to 'see' a wider field of vision than the physiological map predicts. we tested whether monkeys left with only the lower retinal-field portion of their striate map could see with information coming from the upper half of the retina. in 6 rhesus monkeys the ganglion fibers exiti ... | 1976 | 812586 |
| cis-dichlorodiammineplatinum (ii) (nsc-119875): hearing loss and other toxic effects in rhesus monkeys. | ototoxicity and general toxicity of cis-dichlorodiammineplatinum (ii), a compound with antitumor activity, were evaluated in four rhesus monkeys. audiometry was performed with shock avoidance to donditioned stimuli of pure tones at frequencies from 0.25 to 18 khz. histopathologic lesions of the inner ear were identified with phase-contrast microscopy of surface preparations from the organ of corti. the monkeys were also submitted to physical examinations, hematologic and blood chemical determina ... | 1975 | 812603 |
| preclinical studies with triazinate (nsc-139105), an antifolate drug, in beagle dogs and rhesus monkeys. | the effects of the intravenous administration of triazinate by single and multiple injections were studied in beagle dogs and rhesus monkeys. in dogs, dose levels ranging from 0.3125 to 40 mg/kg were given either as single doses daily for 5 days, or once weekly for 6 weeks. the 5-day regimen was also studied in monkeys with dose levels from 2.5 to 40 mg/kg/day. prominent drug-related and drug-dependent effects which appeared in both species were piloerection, muscular weakness, and respiratory d ... | 1975 | 812604 |
| the motor nerve supply of the velopharyngeal muscles. | the present study attempted to clarify the motor nerve supply of the velopharyngeal muscles. experiments were carried out on 20 anesthetized rhesus monkeys. evoked emg responses of the levator veli palatini, uvula, and superior constrictor pharyngeus muscles, which seem to contribute to velopharyngeal closure, were analyzed by stimulating the cranial nerves within the skull. results were as follows: 1. muscle action potentials (m-waves) from the selected muscles could be recognized on stimulatin ... | 1976 | 812618 |
| treatment of postpartum rhesus monkeys with progestogen: appearance in milk and effects on lactation. | | 1975 | 812634 |
| metabolic, endocrine and organ functions in monkeys immunized with pr-beta-hcg-tt vaccine. | the vaccine pr-beta-hcg-tt was injected into 12 rhesus monkeys; 10 monkeys were used as controls. at 3-13 months after immunization, blood and urine samples were examined. hemoglobulin and packed call volumes were unaltered. total leukocyte counts were similar but the percentage of neutrophils was reduced in immunized animals. serum bilirubin, alkaline phosphastase, glutamic oxaloacetic, and glutamic pyruvic transaminases, true and pseudocholinesterases, lactic acid dehydrogenase and its is ... | 1976 | 812636 |
| mechanisms of retinal damage resulting from the exposure of rhesus monkeys to ultrashort laser pulses. | | 1975 | 812713 |
| transmission of hepatitis b to the rhesus monkey. | the rhesus monkey does provide a suitable laboratory animal model for studying hepatitis b virus and for investigating various aspects of interaction between this infectious agent and the host. this species of non-human primate, however, offers a less sensitive animal model for hepatitis b infection than the chimpanzee. | 1975 | 812744 |
| hepatic toxicity in the rhesus monkey treated with chenodeoxycholic acid for 6 months: biochemical and ultrastructural studies. | the long term administration of chenodeoxycholic acid in man has to be regarded with caution because chenodeoxycholic acid has caused liver damage in various species of animals, including primates. to study the effect of three doses of chenodeoxycholic acid (10, 40, and 100 mg per kg per day) on hepatic function and morphology, biliary bile acid composition and the reversibility of changes were investigated in 22 rhesus monkeys. after 6 months of treatment with 40 and 100 mg per kg per day, bile ... | 1976 | 812760 |
| evaluation ofprimary blood monocyte and bone marrow cell culture for the isolation of rickettsia rickettsii. | rickettsia rickettsii was isolated from experimentally infected guinea pigs by culture of blood monocytes and bone marrow cells, and from experimentally infected rhesus monkeys by blood monocyte culture. rickettsiae were identified in monocyte-macrophage monolayers stained by giménez or flourescent antibody techniques. a total of 78 culture attempts were made from 20 guinea pigs and 16 monkeys. the success of isolation of r. rickettsii in culture was positively correlated with the numbers of ric ... | 1975 | 812828 |
| the effect of cholinergic and anticholinergic agents on the primate model of allergic asthma. | rhesus monkeys with reagin-mediated, immediate-type respiratory responses to ascaris antigen were used for comparison with the type of responses that occur from certain pharmacologic agents. carbacholine produces a respiratory response that is the same type as an antigen-induced respiratory response and will sensitize an animal's airway so that a dose of antigen not reactive alone will stimulate a response. antigen and histamine will sensitize the airway so that a subthreshold dose of carbacholi ... | 1976 | 812931 |
| diastolic and systolic blood pressure measurements in monkeys determined by a noninvasive tail-cuff technique. | a noninvasive method to determine systolic, diastolic, and mean blood pressure values in rhesus monkeys is described and evaluated. simultaneous measurements of abdonimal aortic and tail-cuff pressures were compared for unanesthetized, anesthetized, hemorrhaged, and methoxamine-treated animals. data indicated that correlation between direct and indirect methods were highly significant (r greater than or equal to 0.94); the mean differences found between the two measurements were less than or equ ... | 1976 | 812932 |
| studies on plasma corticosteroids in the rhesus monkey (macaca mulatta). | the physiological regulation of the plasma corticosteroid concentration, measured by competitive protein-binding, was studied in female rhesus monkeys (m. mulatta) sedated with phencyclidine hydrochloride. morning basal levels of plasma corticosteroids were found to be in the range 8-0-25-2 mug/100 ml, which is lower than that previously reported in this species. a circadian rhythm in plasma cortisol concentration was demonstrated. prolonged sedation with phencyclidine was associated with a grad ... | 1975 | 812935 |
| disposition of diethylstilbestrol in the rhesus monkey. | | 1975 | 812978 |
| effects of morphine and narcotic antagonists on avoidance behavior of the squirrel monkey. | the effects of morphine, cyclazocine and nalorphine were evaluated on the continuous avoidance behavior of the squirrel monkey with schedule parameters similar to those used in previous studies on the rat. with this schedule, a lever-pressing response postponed or terminated the delivery of an electric shock to the monkey's tail. dose-response curves were determined for each drug administered alone and in combination with 1.0 mg/kg of naloxone. in the 1st hour of a 4-hour session, avoidance resp ... | 1976 | 812979 |
| proceedings: the effect of cooling nucleus interpositus of the cerebellum in rhesus monkeys on the tracking of a visual target. | | 1975 | 812983 |
| prefrontal unit activity during delayed-response and delayed-alternation performances. | in order to examine whether or not the single unit activity of the dorsolateral prefrontal cortex of the rhesus monkey activated during delayed-response task is involved in a delayed-alternation task, the same prefrontal single unit activities were recorded extracellularly using tungsten electrodes while the monkey was performing the two tasks alternatively. visual signals were given to two different locations (left and right) as visual cues and response cues. a total of 95 units were recorded. ... | 1975 | 813043 |
| fetal brain injury after maternal carbon monoxide intoxication. clinical and neuropathologic aspects. | in a model of brain damage in the rhesus monkey fetus, carbon monoxide inhalation by the mother was used to produce graded fetal hypoxia. four fetuses with aterial oxygen contents of 2.1 to 2.4 ml per 100 ml during the most severe insult hour appeared neurologically normal, and their brains contained no lesions. a single animal with an intermediate degree of hypoxia was moderately abnormal; its brain showed extensive necrosis of the basal ganglia. four fetuses with arterial oxygen contents of 1. ... | 1976 | 813158 |
| a method of quantitating injury inflicted in acute spinal cord studies. | spinal cord trauma was induced in cats and rhesus monkeys using an improved method which allows for accurate quantitation of the force delivered. the materials and methods described consist of a weight which is dropped down a centre shaft on to a strain gauge arch assembly which transfers the force to a teflon impounder resting on the exposed dura of the cord. the force transferred from the weight to the impounder is recorded by the strain gauge and thr force curve can be displayed on a storage ... | 1975 | 813173 |
| reversibility of fatty streaks in rhesus monkeys. | | 1976 | 813208 |
| coronary artery fine structure in rhesus monkeys: nonatherosclerotic intimal thickening. | | 1976 | 813209 |
| blood-aqueous barrier can be circumvented by lowering intraocular pressure. | rhesus monkeys were injected intravenously with hypertonic urea (9 ml/kg body weight of 30% urea in 10% invert sugar) and the intraocular pressure was measured with an applamatic tonometer. when this pressure reached its minimum (20% of the normal value) horseradish peroxidase (molecular weight 40,000; radius of an equivalent hydrodynamic sphere about 2.5 nm; 0.5 g/kg body weight), was injected intravenously. twenty minutes following peroxidase administration, either aqueous humor was sampled fr ... | 1976 | 813231 |
| retention of functional tolerance to ethanol in rhesus monkeys (macaca mulatta). | tolerance to ethanol (3 g/kg 90 min prior to testing) was assessed in a group of 4 rhesus monkeys in which tolerance development had been observed using the same behavioral task one year prior to the present study. although some decrements in performance on a two-choice discrimination reversal learning task were observed, these changes were transient and statistically insignificant. results indicate that functional tolerance persisted throughout a one year abstinence period. | 1975 | 813240 |
| maternal estrogen and progesterone levels after hypophysectomy in early pregnancy and in term fetuses or newborn monkeys. | pregnant rhesus monkeys (macaca mulatta) were hypophysectomized at 8-10 weeks gestation to determine effects on plasma levels of estrone (e1), estradiol-17beta (e2), and progesterone (p). the first group of monkeys was subsequently fetectomized at 107-114 days. after hypophysectomy there was an initial decrease in maternal peripheral plasma e2 followed by a rise to preoperative levels within 4-5 weeks. plasma levels of e1 and p were not markedly altered. after fetectomy, peripheral estrogen conc ... | 1975 | 813337 |
| uterine contractility and regional blood flow responses to oxytocin and prostaglandin e2 in pregnant rhesus monkeys. | | 1974 | 813338 |
| comparative effects of hyperosmolar urea administered by intra-amniotic, intravenous, and intraperitoneal routes in rhesus monkeys. | hypertonic urea solutions (58 per cent weight/volume) were injected rapidly into ten anesthetized rhesus monkeys at a dose of approximately 2 gm. per kilogram by the intravenous, intraperitoneal, or intra-amniotic routes. an additional monkey received an intra-amniotic dose of 12.5 gm. per kilogram. a tracer dose 14c-urea was included for measuring absorption and elimination. the following parameters were monitored before and for four hours after urea injection: arterial and cerebrospinal fluid ... | 1976 | 813523 |
| pharmacokinetics of intra-amniotically administered hyperosmolar urea in rhesus monkeys. | three rhesus monkeys in midgestation were injected intra-amniotically with hyperosmolar 14c-urea (58 per cent weight/volume, 2.3 gm. per kilogram, 25 muc) and the concentration of 14c-urea measured serially for 24 hours in amniotic fluid, maternal serum, and maternal urine. the volume of the amniotic space was measured by isotope dilution of 99mtc-albumin. the experimental values were fitted to a three-compartment mathematical model with the aid of a digital computer program for nonlinear data. ... | 1976 | 813524 |
| the relationship of tooth size to body size in a population of rhesus monkeys (macaca mulatta). | tooth areas correlate significantly with long bone measurements in a skeletal population of rhesus monkeys from cayo santiago. correlations are relatively large for the troop as a whole, as well as for males and females separately. femur and humerus length measurements show the higheres correlations with tooth size. | 1975 | 813527 |
| growth of the maxillary complex in the rhesus monkey (macaca mulatta). | the growth of the maxillary complex of 36 rhesus monkeys (macaca mulatta) was analyzed quantitatively and qualitatively during four defined stages of postnatal development (i.e., infant, juvenile, adolescent, young adult). at each stage, growth was observed during a 24 week period. since some animals were observed during two successive stages of development, 47 periods of growth were studied. the incremental growth data were collected by superimposing serial cephalograms on cranial base implants ... | 1976 | 813530 |
| pressure effects on the endothelium of the trabecular wall of schlemm's canal: a study by scanning electron microscopy. | the scanning electron microscope was used to compare the appearances of the endothelial monolayer of the trabecular wall of schlemm's canal in the rhesus monkey after exposure to intracameral pressures of 8, 15 and 22 mm hg for one hour. over this pressure range, the bulges in the spindle-shaped structures in the monolayer became rounder in shape and the number of openings on the surface was apparently greater at 22 mm hg than at 15 and 8 mm hg. a quantitative comparison between the tissue at 8 ... | 1975 | 813538 |
| cardiovascular effects of enflurane and halothane on the rhesus monkey. | ten rhesus monkeys were chronically instrumented to compare the cardiovascular effects of enflurane and halothane. in 17 experiments, each monkey was evaluated in the awake state and after equilibration at each of many anesthetic levels. end-expired gas concentrations were expressed in multiples of human minimum alveolar concentrations (mac) for comparison. there was a predictable dose-related decrease in heart rate, mean arterial pressure, peak left ventricular dp/dt, and the latter divided by ... | 1976 | 813544 |
| functional evaluation of the interposed colon as an esophageal substitute. | five rhesus monkeys and four human adults with colonic reconstruction of the esophagus have been studied by manometric, fluoroscopic and reflux tests. transit through the graft is mainly under the influence of gravity. infrequent colon contractions can be propulsive, and sequential haustral contractions give the appearance of peristalsis. the diaphragmatic hiatus and esophagocolic anastomosis are the sites of weak barriers to reflux which are readily overcome by abdominal compression and gastric ... | 1976 | 813587 |
| [aromatization of 3h-androstenedione in the liver and ovary of a postmenopausal rhesus monkey in vivo]. | | 1975 | 813609 |
| female rhesus sexual behavior and distance to a male partner: relation to stage of the menstrual cycle. | female rhesus monkeys were observed in standardized mating tests during successive menstrual cycles as well as in tests while separated from, but in view of, their male partners. under both conditions, behaviors of the female were noted which varied with the stages of the menstrual cycle. some of the most prominent fluctuations occurred in measures of interindividual distance. in particular, time spent near the male peaked at the time most likely for ovulation. the pattern of changes in this beh ... | 1975 | 813615 |
| experimental argon laser photocoagulation. i. effects on retinal nerve fiber layer. | eight rhesus monkeys were photocoagulated with varying intensities of argon laser energy to determine the effects on the retinal nerve fiber layer. photocoagulation of arterioles and venules always resulted in largely irreversible and permanent perivascular axonal destruction. photocoagulation of areas free of major vessels showed variable responses to identical dosages, ranging from minimal destruction of the outer part of the retina to full-thickness destruction involving the nerve fiber layer ... | 1976 | 813620 |
| thyroxine-binding globulin biosynthesis in isolated monkey hepatocytes. | thyroxine-binding globulin biosynthesis was demonstrated in hepatocytes isolated from normal adult rhesus monkeys. dispersed cells were obtained by in situ liver perfusion with collagenase, hyaluronidase and edta. conditions for optimum cell survival and incorporation of radioactive leucine into newly synthesized proteins were defined. protein synthesis, and specifically thyroxine-binding globulin synthesis, were shown to continue throughout the incubation period, while cell survival remained hi ... | 1976 | 813766 |
| 3-methoxy-4-hydroxyphenylethyleneglycol (mhpg) transport from the spinal cord during spinal subarachnoid perfusion. | spinal subarachnoid perfusions of rhesus monkeys were performed to study the transport of 3-methoxy-4-hydroxyphenylethyleneglycol (mhpg) by the spinal cord. the perfusate contained [3h]mhpg and a reference extracellular space marker ([14c]sucrose of [14c]ethylenediaminetetraacetic acid-calcium complex). the mean (+/- s.d.) clearance of mhpg by the monkey spinal cord was 33 (+/- 4) mul/min. analysis of serial sections of spinal tissue after each perfusion facilitated determination of several basi ... | 1976 | 813817 |
| tissue distribution, binding properties and lesions produced by dehydroretronecine in the nonhuman primate. | four-month-old rhesus monkeys were injected with 65 mg of [3h] dehydroretronecine per kg body weight and sacrificed at 6,12 and 24 h following injection. by the 24th h 13% of the dose had been eliminated in the urine. although there were no feces, the extremely high radioactivity of the bile and intestinal contents suggested this route was a major one for the excretion of this compound. the 3h was distributed throughout the body by the 6th h with the greatest percentage being in the skin and mus ... | 1976 | 813833 |
| plasma neurophysin levels in monkeys: emphasis on the hypothalamic response to estrogen and ovarian events. | specific radioimmunoassays for human neurophysins released in response to estrogen (estrogen-stimulated neurophysin, esn) and nicotine (nicotine-stimulated neurophysin, nsn) have been used to measure two similar neurophysins in rhesus monkey plasma. as in the human, concentrations of rhesus monkey neurophysins in plasma were specifically produced a marked increase of plasma nsn concentrations in the monkey. estradiol benzoate administered intramuscularly consistently produced an increase in plas ... | 1976 | 813993 |
| some cortical projections to the parahippocampal area in the rhesus monkey. | | 1976 | 814012 |
| reversible inhibition of ovulation in the rhesus monkey by polydimethylsiloxane subdermal capsules of megestrol acetate. | the effect of megestrol acetate in polydimethylsiloxane subcutaneous implants on menstrual cycle, ovarian function, and uterine histology of adult parous rhesus monkeys was studied. release rates of 129.6 and 64.8 mug/day inhibited ovulation and produced amenorrhea in all of the treated monkeys. the plasma progesterone level was 0 ng/ml during the initial part of the study (8 months). endometrial biopsies obtained at different times showed a suppressed endometrium. approximately 30 days after re ... | 1976 | 814022 |
| an experimental model of aortic coarctation in rhesus monkeys. | | 1975 | 814086 |
| determination of body surface area in the rhesus monkey. | body surface areas (bsa) of 31 apparently normal rhesus monkeys of both sexes weighing 3.2-5.3 kg were determined by the direct skinning technique. the range of measured bsa was 1,940-3,020 cm2 (mean = 2,430 cm2). the bsa values of male and female monkeys were not significantly different. the k value, calculated as the ratio of bsa (cm2)/body wt2/3 (kg), was 969 +/- 15 (se). based on the principle of least squares for goodness of fit between the measured and calculated bsa, the best equation was ... | 1976 | 814115 |
| stimulation of rhesus monkey gh release: arginine vs plasma volume expansion. | plasma gh and cortisol responses were examined in unanesthetized adult male rhesus monkeys infused with approximately 30 ml (8.3 ml/kg) of arginine monohydrochloride (arg 0.5 g/kg), 0.9% saline (ns) or dextran 75 and following 15 ml infusions of acid-saline (as), or somatostatin (ghrih 30 mug/kg). none of the infusions were accompanied by gh elevations. rebound gh elevations occurred after each 30 ml infusion and after ghrih but not after 15 ml as. although the amplitude of gh responses were not ... | 1976 | 814133 |
| stereotaxic coordinates for the rhesus monkey thalamus and mesencephalon referencing visual afferents and cytoarchitecture. | when using a stereotaxic instrument for visual field stimulation we found that electrode placements in the thalamus and mesencephalon of prone rhesus monkeys with the aid of avaiable atlases showed considerable errors. as these animals are valuable for primate visual system reseach an atlas was constructed with methods that have not been used before for rhesus. in addition, the specific connections from the visual cortices, superior colliculus and retina to the thalamus and mesencephalon are als ... | 1975 | 814157 |
| behavioral control of visual fixation of the rhesus monkey. | a paradigm for the control of visual fixation of the macaque monkey in vision experiments was described. using a maxwellian view, the procedure permits the placement of discrete test-light stimuli in a specific area of the retina as the monkey fixates a primary target. this procedure holds foveal fixation as other behaviorally significant visual stimuli are presented to the visual field. by a methods-of-limits procedure, the sensitivity of the monkey eye was measured at different retinal locatio ... | 1976 | 814190 |
| relative reinforcer magnitude under a nonindependent concurrent schedule of cocaine reinforcement in rhesus monkeys. | lever pressing by three rhesus monkeys was maintained under a two-lever concurrent schedule of cocaine reinforcement. responding on one lever (constant-dose lever) produced a constant dose of 0.05 or 0.1 mg/kg/injection arranged according to a variable-interval 1-min schedule. responding on the other lever (variable-dose lever) produced a comparison dose of cocaine (0.013 to 0.8 mg/kg/injection), also under a variable-interval 1-min schedule. the two variable-interval schedules were made noninde ... | 1976 | 814191 |
| behavior controlled by scheduled injections of cocaine in squirrel and rhesus monkeys. | rates and patterns of key-press responding maintained under schedules in which responding resulted in intravenous injections of cocaine were studied in squirrel monkeys and rhesus monkeys. each injection was followed by a 60- or 100-sec timeout period. schedule-controlled behavior was obtained at appropriate cocaine doses in each species. under fr 10 or fr 30 schedules, performance was characterized by high rates of responding (usually more than one response per second) in each ratio. under fi 5 ... | 1976 | 814192 |
| the pathology of measles in abyssinian colobus monkeys (colobus guereza): a description of an outbreak. | the pathological changes found in four abyssinian colobus monkeys (colobus guereza) dying of measles are described. warthin-finkeldey giant cells were plentiful in the lymphoid tissue and spleen, in the mucosa of the alimentary tract and in the lungs, where they accompanied a non-suppurative pneumonia. in the alimentary tract they were most frequent in the colon when an associated colitis was present. measles virus was recovered from the lung tissue of one animal, the virus being neutralised by ... | 1975 | 814224 |
| early diagnosis of rocky mountain spotted fever. use of primary monocyte culture technique. | diagnosis of rocky mountain spotted fever was made as early as the fourth day of febrile illness in rhesus monkeys (macaca mulatta), with a monocyte culture technique that is easily amenable to use in humans. rickettsia rickettsii were identified by direct immunofluorescent and gimenez staining of cultures of circulating monocytes from four experimentally infected monkeys, even in the presence of a mild or inapparent disease in three. levels of rickettsemia were estimated by the plaque-assay tec ... | 1976 | 814256 |
| the possible deleterious effects of the intramyometrial injection of hypertonic urea. | hypertonic urea has been shown to be an effective midtrimester abortifacient. although safer than hypertonic saline when injected intravascularly, it has not been compared to saline in the case of inadvertent intramyometrial injection. this report documents that intramyometrial injection of hypertonic urea will result in the same type of muscle necrosis as that produced by saline. | 1976 | 814512 |
| periparturitional serum concentrations of prolactin, the gonadotropins, and the gonadal hormones in the rhesus monkey. | the time courses of serum concentrations of prolactin, estradiol, estrone, progesterone, lh, and fsh were studied in seven pregnant rhesus monkeys from 1 month prior to delivery until 1 month after parturition. all animals nursed their young. circulating levels of estradiol and estrone increased during the last few days of pregnancy, reaching peak values of 700 pg/ml and 350 pg/ml, respectively, on the day prior to delivery, fell precipitously to about 25 pg/ml within 1 day after parturition, a ... | 1976 | 814548 |
| phencyclidine sedation as a technique for handling rhesus monkeys: effects on lh, gh, and prolactin secretion. | rhesus monkeys, sedated with phencyclidine hydrochloride (sernylan), were quieted for prolonged periods of time, while maintaining somatic reflexes, muscle tone, and respiration. brief daily periods of sedation did not interfere with the menstrual cycle. prolonged sedation, however, interfered with the experimentally estrogen-induced lh surge, but not with the inhibitory action of estrogen on lh tonic secretion. pulsatile release of lh, gh, and prolactin persisted even under prolonged sedation. ... | 1976 | 814551 |
| prostaglandin e1 specific binding in rhesus myometrium. | myometrial low speed supernatant prepared from non-pregnant rhesus uteri was incubated with 3h-prostaglandin (pg)e1 with or without addition of unlabelled prostaglandins. the uptake of 3h-pge1 was inhibited in a dose dependent fashion by pge2greater thanpge1greater thanpga1greater thanpgf2alpha=pga1greater thanpgb1=pgb2greater than or equal topgd2. pge1 metabolites inhibited 3h-pge1 binding in the following order: 13, 14-dihydro-pge1greater than13,14-dihydro-15-keto-pge1=15-keto-pge1. the specif ... | 1975 | 814585 |
| effects of secretin and cholecystokinin on relative composition of hepatic bile in rhesus monkeys. | | 1975 | 814640 |
| direct fascicular repair and interfascicular nerve grafting of median and ulnar nerves in rhesus monkeys. | | 1975 | 814647 |
| a comparison of rhodnius prolixus, triatoma infestans and panstrongylus megistus in the xenodiagnosis of a chronic trypanosoma (schizotrypanum) cruzi infection in a rhesus monkey (macaca mullatta). | fifth instar rhodnius prolixus, triatoma infestans and panstrongylus megistus were fed on a rhesus monkey (macaca mullatta) with a chronic infection of peru strain trypanosoma cruzi and examined 30 days later for the presence of trypanosomes in the rectum. no correlation could be demonstrated between either blood meal size or sex and the subsequent development of a rectal infection with t. cruzi. as t. infestans and p. megistus were more highly infected than r. prolixus in terms of both percenta ... | 1975 | 814658 |
| [normal antistreptolysin titres and demonstration of rheumatoid factors in rhesus monkeys (macaca mulatta) (author's transl)]. | rhesus monkeys are often used as experimental animals. many clinical and biochemical parameters are known but there are only few papers dealing with the normal values of antistreptolysin o (asl). informations about antistreptococcal antibodies are necessary in order to follow the course of immunization and infection experiments. when non-absorbed sera were used, the mean value of antistreptolysin o in clinically healthy rhesus monkeys (macacus rhesus) amounted to 178 +/- 52 asu. after absorption ... | 1975 | 814744 |
| [effect of hormonal contraceptives on endometrial deposit in rhesus monkeys]. | | 1975 | 814765 |
| effects of a low-protein diet during pregnancy of the rhesus monkey i. reproductive efficiency. | pregnant rhesus monkeys were fed a control diet of modified cow's milk or an experimental diet containing only 25% as much as protein but made isocaloric with supplemental lactose. the ad libitum consumption of the control and experimental diets provided about 2 and 0.5 g of protein/kg of body weight per day, respectively. total volume and energy consumption of control and experimental animals were generally comparable per kilogram of body weight, with groups showing a reduction in intake of abo ... | 1976 | 814804 |
| cholecystokinin-decreased food intake in rhesus monkeys. | five rhesus monkeys were infused intravenously with partially purified cholecystokinin (cck) just prior to a test meal of solid food after overnight food deprivation; cck produced large, rapid, dose related suppressions of feeding. the lowest dose tested (5 ivy u/kg body wt) produced a significant inhibition of food intake (26% suppression, p less than 0.05). equivalent infusions of partially purified cck or the synthetic cooh-terminal octapeptide of cck (a pure fragment with all the biological ... | 1976 | 814821 |
| cervical retraction of the maxillae in the macaca mulatta monkey using heavy orthopedic force. | heavy, interupted orthopedic forces were employed for the cervical retraction of the maxillae in two macaca mulatta monkeys. the nature, location and magnitude of resultant movements and remodelling were studied with the help of plaster casts, amalgam implants, lateral cephalometric tracings, and of gross and microscopic study of the skulls themselves. the principal effect of the retractive force was a marked downward and backward rotational movement of the maxillae which carried the maxillary t ... | 1976 | 814848 |
| [comparative studies on placenta specific proteins in man and subhuman primates (author's transl)]. | it is shown that in placentae and partly also in sera from pregnant monkeys (chimpanzee, baboon, rhesus monkey and cynomolgus) proteins occur which are immunochemically related to the human placental specific antigens hpl (human placental locatogen), sp1 (pregnancy specific beta1-glycoprotein), pp5 (placental protein 5) and hsap (heat stable alkaline phosphatase). the immunochemical and physico-chemical properties of these monkey proteins are compared with those of the corresponding human protei ... | 1975 | 814878 |
| changes in cortical subarachnoid fluid potassium concentrations during hypoxia. | seventeen rhesus monkeys underwent 20-minute episodes of hypoxia (mean po2, 18 to 28 mm hg). in 14 animals that maintained mean blood pressures greater than 60 mm hg, increases in potassium concentration averaging greater than 1 meq/liter were observed in the cortical subarachnoid fluid. these changes were reversible with oxygen administration and were usually not associated with morphologic evidence of brain injury. cisterna magna fluid, sampled in five animals, showed smaller increases in pota ... | 1976 | 814882 |
| covalent structure of apolipoprotein a-ii from macaca mulatta serum high-density lipoproteins. | the covalent structure of apolipoprotein a-ii, isolated from the serum high-density lipoprotein of a single male rhesus monkey (macaca mulatta), was determined. the amino acid sequence of this 77-residue polypeptide is: less than glu-ala-glu-glu-pro5-ser-val-glu-ser-leu10-val-ser-gln-tyr-phe15-gln-thr-val-thr-asp20-tyr-gly-lys-asp-leu25-met-glu-lys-val-lys30-ser-pro-glu-leu-gln35-ala-gln-ala-lys-ala40-tyr-phe-glu-lys-ser45-lys-glu-gln-leu-thr50-pro-leu-val-lys-lys55-ala-gly-thr-asp-leu60-val-asn ... | 1976 | 814923 |
| control of placental 3 beta-hydroxy-delta5-steroid dehydrogenase: comparison of enzyme characteristics in man, cow, goat, rat and rhesus monkey. | | 1976 | 814935 |
| the myelinated parallel fibers of the cerebellar cortex and their regional distribution. | in the cerebellar cortex of the rhesus monkey and the cat, the supraganglionic plexus in the molecular layer exhibits regional differences. the plexus is very well developed in the vermal parts of the anterior lobe, but only poorly developed in the nodulofloccular lobe. most of the fibers of this plexus are myelinated parallel fibers, which synapse in the typical manner with dendritic thorns of purkinje cells. only very few fibers of this plexus are recurrent collaterals of purkinje cells. their ... | 1976 | 815002 |
| effect of prosencephalectomy on the connections of the inferior olivary nucleus in fetal rhesus monkeys. | | 1976 | 815099 |
| selective responding by recently separated juvenile rhesus monkeys to the calls of their mothers. | four juvenile rhesus monkeys responded to the coo-type vocalization of their respective mothers by increasing dramatically their own vocalization rate and their locomotor activities. the juveniles appeared quite disturbed when they heard their mothers voices and this disturbance was, with one exception, apparently specific to their own mothers. | 1976 | 815120 |
| protein deprivation in primates: vii. determinants of size and skeletal maturity at birth in rhesus monkeys. | | 1976 | 815156 |
| intravenous cholangiography in the rhesus monkey. part i: determination of optimal iodipamide dose during a one-hour infusion. | one-hour infusion intravenous cholangiography with iodipamide was performed in 3 rhesus monkeys with intact enterohepatic circulations. a series of four different doses including standard (0.3 ml/kg) and "double dose" (0.6 ml/kg) levels were compared. the 0.6 ml/kg dose resulted in significantly higher biliary iodine excretion and concentration than the lower two doses. a 1.2 ml/kg dose probably increased biliary iodine concentration a small amount when compared to the 0.6 ml/kg dose but did not ... | 1976 | 815196 |
| proceedings: suppression of experimental allergic encephalomyelitis in rhesus monkeys by a synthetic basic copolymer. | | 1975 | 815199 |
| antigen heterogeneity of human b and t lymphocytes. | rhesus monkeys were immunized with normal human lymphoid cells, cultured lymphoid cells, and chronic leukemic lymphocytes. antisera were analyzed by cytotoxicity and immunofluorescence techniques to study the antigenic characteristics of human lymphocytes. in an attempt to obtain a reagent specifically reactive with t (thymus-derived) lymphocytes, an antispleen antiserum was absorbed with cellf from five b- (bone marrow-derived) cell lines. after absorption, the antiserum killed 60-75% of periph ... | 1976 | 815274 |
| replication of dengue viruses in cultures of peripheral blood leukocytes from dengue-immune rhesus monkeys. | dengue virus of types 1, 2, and 4 replicated reproducibly in cultures of peripheral blood leukocytes from 18 dengue-immune rhesus monkeys but failed to multiple in peripheral blood leukocytes from 25 nonimmune monkeys. replication was observed at input multiplicity of infection of 0.1 and 0.01 but irregularly at less than or equal to 0.001. dengue viruses in permissive leukocytes achieved maximal titers on days 2-4 of culture. viral replication in peripheral blood leukocytes from animals immune ... | 1976 | 815444 |
| experimental production of respiratory tract infection with mycoplasma pneumoniae in rhesus monkeys. | knowledge of the pathogenesis of pneumonia due to mycoplasma pneumoniae has been derived primarily from experimental infection of rodents. as part of an effort to establish a model with a closer resemblance to man, three seronegative, young, adult rhesus monkeys (macaca mulatta) were inoculated with m. pneumoniae (10(7.4) cfu per animal) by oropharyngeal administration of coarse-particle aerosol. five to six days after exposure of the animals, cultures obtained from the upper respiratory tract w ... | 1976 | 815446 |
| cortisol in amniotic fluid of rhesus monkeys. | | 1976 | 815506 |
| contribution of auditory cortex to sound localization in the monkey (macaca mulatta). | monkeys with lesions of auditory cortex were tested for their ability to localize the source of brief sounds. although those deprived of primary auditory cortex bilaterally were able to indicate the direction of a sound with near-normal acuity, they were unable to locate its source. this dissociation of abilities suggest that the role of auditory cortex in sound localization is not so much sensory or perceptual as it is auditomotor or associative. thus, sound localization joins loudness, pitch, ... | 1975 | 815514 |
| a peripheral "cold" fiber population responsive to innocuous and noxious thermal stimuli applied to monkey's face. | the activity of 134 cold fibers innervating the hairy skin of the face was recorded from fine dissected strands of the infraorbital nerve in rhesus monkeys anesthetized with sodium pentobarbital. a precisely controlled contact thermode was used to produce rapid temperature shifts of approximately 10 degrees c/s in the cooling and warming directions with a 20-60 degrees c range. cold fiber receptive fields usually were single spots less than 300 mum in diameter. the mean conduction velocity of 94 ... | 1975 | 815515 |
| preserved autoregulation in the rhesus spinal cord after high cervical cord section. | the authors studied the effect of high cervical cord section on the phenomenon of autoregulation in the rhesus monkey with the hydrogen clearance method to measure focal spinal cord blood flow (scbf). laminectomies were performed at t7-11 and c1-2. the spinal cord was completely severed at c1-2. under normocapnic conditions, scbf was then measured in the thoracic spinal cord over a wide range of blood pressures (map). the map was either lowered by bleeding or raised by the intravenous infusion o ... | 1976 | 815520 |
| biological basis for vertical ramus osteotomies--a study of bone healing and revascularization in adult rhesus monkeys. | fifteen adult rhesus monkeys were used as experimental models to investigate revascularization and bone healing associated with pedicled and nonpedicled vertical ramus osteotomies and to elucidate the problem of vascular ischemia of the proximal segment and healing of the osteotomized bone. microangiographic and histologic studies of vertical ramus osteotomies in which the proximal segment was not pedicled to soft tissue showed intraosseous necrosis, vascular ischemia, and delayed healing. simil ... | 1976 | 815526 |
| anatrichosoma cynamolgi (nematoda: trichinellida) in rhesus monkeys, macaca mulatta. | young adult rhesus monkeys were examined for anatrichosoma spp. by means of nasal swab, by histological study, and by gross examination with the aid of a dissecting microscope. of 394 monkeys examined by nasal swab, 25 (6.3%) were found to be positive. of 166 monkeys that died while in the colony, 23 (13.9%) were found to be infected when examined by histological study. of 18 unfixed samples of external nasal vestibule, five (27.2%) were found to be infected when they were examined grossly with ... | 1976 | 815529 |
| effects of electrosurgery on the gingival attachment in rhesus monkeys. | a biometric and histometric study of electrosurgical gingival "troughing" with a fully rectified current was accomplished in four rhesus monkeys. the operation resulted in a statistically significant recession of the free gingival margin and loss of connective tissue attachment associated with apical migration of the junctional epithelium. burn marks from contacts with the electrodes were observed on the cemental surfaces and in the dentin under the enamel close to the cemento-enamel junction. t ... | 1976 | 815538 |
| morphine, pentazocine and naloxone effects on responding under a multiple schedule of reinforcement in rhesus monkeys and pigeons. | the effects of morphine, pentazocine, naloxone and combinations of these drugs on schedule-controlled behavior were examined in rhesus monkeys and pigeons. the order of potency in decreasing response rates under a multiple 5-minute fixed-interval, 30-response fixed-ratio schedule in both monkeys and pigeons was morphine greater than pentazocine greater than naloxone. compared to monkeys, pigeons were less sensitive to morphine and pentazocine and slightly more sensitive to naloxone. in monkeys a ... | 1976 | 815542 |
| rehabilitation of grossly deficient mandibles with combined subperiosteal implants and bone grafts. | 1. this study has described the osseous reconstruction of deficient edentulous ridges in adult rhesus monkeys. the rebuilt osseous ridges did not resorb under complete prosthetic function over a 4 month period. 2. remodeling of the graft proceeded along the usually observed patterns with mature cortices forming in the grafted areas within 6 months. 3. this procedure has been duplicated for clinical patients with reasonably good results, restoring function in otherwise untenable prosthetic situat ... | 1976 | 815546 |
| a measles epizootic with 5 deaths in newly-imported rhesus monkeys (macaca mulatta). | of 21 newly-imported rhesus monkeys, 11 showed a typical macular rash and 13 developed a 4-fold or greater rise in antibody titre to measles. 5 animals died, 4 of them with extensive pneumonia, pleurisy and pericarditis. although measles was involved in each case, there were contributory causes of death, namely diplococcus pneumoniae and staphylococcus aureus infection, and infestation with oesophagostomum (nodular worm) larvae. | 1976 | 815718 |
| intravenous hepatosplenography. experiment evaluation of a new contrast material. | a new, lipoid-based experimental contrast material (ag 60-99) was intravenously infused into 29 rhesus monkeys. the injections resulted in dense hepatosplenograms, preserving diagnostic quality for over 24 hours, and enabling routine utilization of tomography. this technique is capable of demonstrating simulated hepatic masses as small as 5 mm in diameter in vivo. limited histopathologic and toxicity studies showed no serious or lasting toxic manifestations from ag 60-99 and none of the animals ... | 1976 | 815953 |
| anatomical study of cerebral asymmetry in the temporal lobe of humans, chimpanzees, and rhesus monkeys. | it is generally accepted that anatomical asymmetries in the temporal lobe language region of humans are associated with the asymmetrical representation of language function in the left hemisphere. comparative measurements were taken of the length of the left and right sylvian fissures of human, chimpanzee, and rhesus monkey brains. measurements confirmed the findings of other studies that the human sylvian fissure is longer on the left than on the right. the chimpanzee brains had a similar asymm ... | 1976 | 816005 |
| further studies on histamine in spinal cord injury and post traumatic hyperemia. | using the hydrogen clearance method, focal spinal cord blood flow was measured in the lateral funiculus of rhesus monkeys traumatized with a 600 gm cm injury to t10, pretreated with either chlorpheniramine or metiamide. the blood flow in the chlropheniramine treated animals either rose slightly or remained in the normal range. that in the metiamide treated animals remained in the normal range at all times in all animals. on the basis of these results we can further define the previously observed ... | 1976 | 816022 |
| test flash intensity and variability of fixation by the rhesus monkey. | | 1976 | 816081 |
| correlation of histologic and electroretinographic changes in peripheral retinal ablation in the rhesus monkey. | we studied the effect of peripheral retinal ablation on the electroretinograms of five rhesus monkeys. an ablation procedure analogous to that commonly used in the treatment of diabetic retinopathy was carried out with an argon laser photocoagulator. quantitative histologic measures showed retinal destruction of about 13% of total retinal area. this was associated with about a 50% reduction in scotopic electroretinographic amplitude. | 1976 | 816202 |
| dynamics of thrombus formation on an artificial surface in vivo. effects of antithrombotic agents. | a nonhuman primate model for in vivo evaluation of antithrombotic agents is described. in this model, the formation of a thrombus on a segment of silastic tubing placed in the vena cava of a rhesus monkey is utilized to evaluate the effectiveness of antithrombotic agents. thrombus formation in this model was found to occur rapidly, but this initial deposit quickly was followed by a reduction in thrombus weight. eventually, after 2 hours of implantation of the test device, thrombus weight again i ... | 1976 | 816203 |
| the density of long limb bones and the percentage ash weight of the skeleton of macaca mulatta. | the gravimetric density of humeri, radii, femora and tibiae from a series of 274 male and female skeletons of rhesus monkeys, macaca mulatta, was determined for fetal, young and adult periods. the ages of 171 of the animals were known: they ranged from 57 days of gestation to 13.6 years; the ages of an additional 103 skeletons were estimated. the mean density of the fetal bones was found to increase linearly with age and was higher for males than females, and higher for the superior than for the ... | 1976 | 816204 |
| blood-brain barrier permeability of 11c-labeled alcohols and 15o-labeled water. | the extraction of 11c-labeled methanol, ethanol, and isopropanol, as well as 15o-labeled water by the brain during a single capillary transit, was studied in vivo in six adult rhesus monkeys by external detection of the time course of these tracers subsequent to their internal carotid artery injection. the data demonstrate the feasibility of accurately measuring brain permeability of highly diffusible substances by this technique and show that neither water nor the alcohols studied freely equili ... | 1976 | 816209 |
| evaluating new antimalarial drugs against trophozoite induced plasmodium cynomolgi malaria in rhesus monkeys. | an antimalarial drug testing system is described which utilizes trophozoite induced plasmodium cynomolgi malaria in rhesus monkeys. the schizonticidal activity of standard antimalarial drugs in this system is reported. the system accurately predicted antimalarial activity in man of 8 of 9 compounds selected for clinical trials. | 1976 | 816211 |
| immunizing efficacy of a kenyan strain of schistosoma mansoni in rhesus monkeys (macaca mulatta). | the efficacy as an immunizing agent of the kenyan strain of schistosoma mansoni against challenge infection in rhesus monkeys was demonstrated. an initial exposure of 200 cercariae immunized monkeys against a challenge dose of 2,000 cercariae administered 16 weeks later. the penetration rate in rhesus monkeys was 99%, the same as in baboons. the prolongation of the time for immunity to develop in baboons, compared to rhesus monkeys, shown with this strain of s. mansoni is therefore not due to a ... | 1976 | 816221 |
| fine structure of labelled axons in the cerebellar cortex and nuclei of rodents and primates after intraventricular infusions with tritiated serotonin. | the cerebellar cortex and deep cerebellar nuclei in rats and rhesus monkey were studied after treatment with monoamine oxidase inhibitor and continuous intraventricular infusion with 10(-5) m serotonin-3h. autoradiographs were prepared for light and electron microscopy. the cerebellum contained no labelled cells. labelled unmyelinated axons arrive from the brain stem via the periventricular zones of the aqueduct and fourth ventricle. in the parafloccular cortex about 1 per cent of the mossy fibe ... | 1975 | 816225 |
| the use of ultraviolet light to induce melanogenesis in the epidermis of the rhesus monkey: an ultrastructural and biochemical study. | the general body epidermis of the rhesus monkey (macaca mulatta) contains no discernible melanocytes, but after repeated ultraviolet irradiation dopa-positive melanocytes appear and increase numerically up to 30 exposures. with continued irradiation, however, the number again declines. experiments to determine how melanogenic activity, assayed by the incorporation of labeled dopa or tyrosine, is related to dopa positivity indicated that biochemical activity corresponded to the histochemical patt ... | 1976 | 816226 |
| ambisexual behavior with male-male anal penetration in male rhesus monkeys. | one pair of male rhesus monkeys reared in the laboratory with exclusive social access to each other during their second year of life were observed to display reciprocal mounting with anal penetration on several occasions. their mounts were of comparable duration to those which have been observed in matching heterosexual pairs, by contrast with the brief mounts which are often observed in dominance interactions. the postures exhibited by the mounted male resembled those typical of females during ... | 1976 | 816329 |
| induction of diarrhea in colostrum-deprived newborn rhesus monkeys with the human reovirus-like agent of infantile gastroenteritis. | diarrhea developed in five newborn rhesus monkeys (macaca mulatta) inoculated orally on the first day of life with the human reovirus-like agent of infantile gastroenteritis. incubation period ranged from 2-5 days; virus particles were detected in stools in association with illness, and virus shedding lasted between 1 and 3 days. virus derived from monkeys that developed illness following inoculation was infectious for other monkeys but did not induce diarrhea which could be associated temporall ... | 1976 | 816334 |