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from the centers for disease control and prevention. update: severe acute respiratory syndrome--united states, may 21, 2003. 200312799397
severe acute respiratory syndrome (sars): an old virus jumping into a new host or a new creation? 200312799480
severe acute respiratory syndrome and its lesions in digestive system.severe acute respiratory syndrome (sars) is an infectious atypical pneumonia that has recently been recognized in the patients in 32 countries and regions. this brief review summarizes some of the initial etiologic findings, pathological description, and its lesions of digestive system caused by sars virus. it is an attempt to draw gastroenterologists and hepatologists' attention to this fatal illness, especially when it manifests itself initially as digestive symptoms.200312800212
[severe acute respiratory syndrome (sars)].on november 2002, 305 cases of atypical pneumonia appeared in southern china. in february 2003, cases were reported in hong kong and from there the disease spread to many other countries, mainly, china, hong kong, singapore, vietnam and toronto in canada. the syndrome was defined as severe acute respiratory syndrome sars), and a person is suspected of having sars if he/she became ill after november 1 2002, has a fever exceeding 38 degrees c, has symptoms of a respiratory disease and was in a ris ...200312803049
update: severe acute respiratory syndrome--toronto, canada, 2003.severe acute respiratory syndrome (sars) was first recognized in toronto in a woman who returned from hong kong on february 23, 2003 (1). transmission to other persons resulted subsequently in an outbreak among 257 persons in several greater toronto area (gta) hospitals. after implementation of provincewide public health measures that included strict infection-control practices, the number of recognized cases of sars declined substantially, and no cases were detected after april 20. on april 30, ...200312803194
update: severe acute respiratory syndrome--united states, june 11, 2003.cdc continues to work with state and local health departments, the world health organization (who), and other partners to investigate cases of severe acute respiratory syndrome (sars). this report updates sars cases reported worldwide and in the united states, and describes the eighth probable u.s. sars case with laboratory evidence of sars-associated coronavirus (sars-cov) infection.200312803196
update: severe acute respiratory syndrome--united states, june 4, 2003.cdc continues to work with state and local health departments, the world health organization (who), and other partners to investigate cases of severe acute respiratory syndrome (sars). this report updates sars cases reported worldwide and in the united states and summarizes changes in cdc's recommendations for travel to singapore and hong kong and the resulting modification to the interim u.s. case definition for sars.200312803200
novel coronavirus associated with sars outbreak. 200312806600
[microterrorists with own agenda]. 200312806661
[severe acute respiratory syndrome]. 200312806925
severe acute respiratory syndrome--taiwan, 2003.on april 22, 2003, the taiwan department of health (doh) was notified of seven cases of severe acute respiratory syndrome (sars) among health-care workers (hcws) at a large municipal hospital in taipei (hospital a). subsequent cases at eight hospitals have been associated with exposures at hospital a. previously, all reported cases had been associated with persons recently returning to taiwan from sars-affected regions. this report summarizes epidemiologic findings of the outbreak in taiwan and ...200312807078
update: severe acute respiratory syndrome--united states, may 21, 2003.cdc continues to work with state and local health departments, the world health organization (who), and other partners to investigate cases of severe acute respiratory syndrome (sars). this report updates sars cases reported worldwide and in the united states and highlights recent modifications to the u.s. sars case definition that define criteria for exclusion of previously reported sars cases and for reporting travel-associated cases of sars.200312807079
cluster of severe acute respiratory syndrome cases among protected health-care workers--toronto, canada, april 2003.infections among health-care workers (hcws) have been a common feature of severe acute respiratory syndrome (sars) since its emergence. the majority of these infections have occurred in locations where infection-control precautions either had not been instituted or had been instituted but were not followed. recommended infection-control precautions include the use of negative-pressure isolation rooms where available; n95 or higher level of respiratory protection; gloves, gowns, and eye protectio ...200312807083
update: severe acute respiratory syndrome--united states, may 14, 2003.cdc continues to work with state and local health departments, the world health organization (who), and other partners to investigate cases of severe acute respiratory syndrome (sars). this report provides an update on reported sars cases worldwide and in the united states.200312807084
severe acute respiratory syndrome--singapore, 2003.the singapore ministry of health (moh), with assistance from the world health organization (who), has been investigating an outbreak of severe acute respiratory syndrome (sars). this is a novel condition caused by the sars-associated coronavirus (sars-cov) and is characterized by both an atypical pneumonia and efficient nosocomial transmission. this report summarizes epidemiologic features of this outbreak in singapore, including the influence of super spreaders and the national prevention and c ...200312807088
update: severe acute respiratory syndrome--united states, 2003.cdc, in collaboration with state and local health departments, the world health organization (who), and other partners, continues to investigate cases of severe acute respiratory syndrome (sars). during november 1, 2002-may 7, 2003, a total of 6,903 sars cases were reported to who from 29 countries, including the united states; 495 deaths (case-fatality proportion: 7.2%) have been reported. this report updates information on reported u.s. sars cases.200312807089
a new infectious disease challenge: urbani severe acute respiratory syndrome (sars) associated coronavirus. 200312807475
lessons learned. 200312808698
update: severe acute respiratory syndrome--united states, may 28, 2003.cdc continues to work with state and local health departments, the world health organization (who), and other partners to investigate cases of severe acute respiratory syndrome (sars). this report updates sars cases reported worldwide and in the united states and reports a seventh laboratory-confirmed u.s. case.200312809112
mrna cap-1 methyltransferase in the sars genome.the 3d jury system has predicted the methyltransferase fold for the nsp13 protein of the sars coronavirus. based on the conservation of a characteristic tetrad of residues, the mrna cap-1 methyltransferase function has been assigned to this protein, which has potential implications for antiviral therapy.200312809601
sars: at least and at last, are we learning from the worst? 200312809801
[severe acute respiratory syndrome (sars)].severe acute respiratory syndrome (sars) is a viral disease, observed primarily in southern china in november 2002, with variable flu-like symptoms and pneumonia, in approx. 5% leading to death from respiratory distress syndrome (rds). the disease was spread over more than 30 states all over the globe by sars-virus-infected travelers. who and cdc received first information about a new syndrome by the end of february 2003, after the first cases outside the republic of china had been observed. a c ...200312811416
[severe acute respiratory syndrome (sars)].the severe acute respiratory syndrome (sars) is a highly infectious respiratory disease, to the best of our knowledge caused by a hitherto unknown corona virus. the virus has spread from south east asia to many countries of the world. three case reports of patients from the prince of wales hospital of the chinese university of hong kong demonstrate typical clinical courses. fever, cough, in most cases non-productive, myalgia, chills, and rigor are the leading symptoms. leucopenia and thrombocyto ...200312813666
[sars--the facts. transmission, diagnosis and managing suspected cases].severe acute respiratory syndrome (sars) is a new infectious disease that, in the short period between 1 february and 24 april 2003, has been diagnosed in more than 4000 patients. its origin was traced to guandong, a province in southeast china. the culprit organism was identified as a new coronavirus. the clinical presentation is unspecific and includes fever, respiratory symptoms, lymphopenia and pulmonary infiltrates on x-ray. essential steps to prevent further dissemination of the virus are ...200312813976
severe acute respiratory syndrome coronavirus and viral mimicry. 200312814734
china and germany join forces over sars. 200312815391
update: severe acute respiratory syndrome--united states, june 18, 2003.cdc continues to work with state and local health departments, the world health organization (who), and other partners to investigate cases of severe acute respiratory syndrome (sars). this report updates reported sars cases worldwide and in the united states and summarizes changes in travel recommendations for provinces in china with the exclusion of beijing, where a travel advisory remains.200312816108
sars wars: confronting a new microbe. 200312818820
from the centers for disease control and prevention. severe acute respiratory syndrome--singapore, 2003. 200312824198
from the centers for disease control and prevention. update: severe acute respiratory syndrome--united states, may 28, 2003. 200312824199
severe acute respiratory syndrome.the mysterious severe acute respiratory syndrome (sars) that has originated from the southern chinese province of guangdong appears to be a major public health threat and medical challenge. laboratory studies of sars patients in a number of countries identified the etiologic agent being a novel member of coronaviridae. high rna concentrations of this virus in sputum make it as a highly infectious agent. low concentrations of viral genome are also detectable in feces. coronaviruses are ubiquitos. ...200312824956
pentoxifylline and severe acute respiratory syndrome (sars): a drug to be considered.the recent outbreak of severe acute respiratory syndrome (sars) as a new viral disease is causing a great concern for health authorities and general population. very little is known about the infectious agent (a coronavirus) and its etiopathogeny, having no specific treatment yet. proinflammatory cytokines released by stimulated macrophages in the alveoli could have a prominent role in pathogenesis of sars. current treatment of sars with antiviral agents such as ribavirin and corticosteroids hav ...200312824965
[sars (severe acute respiratory syndrome). from which animal does this coronavirus originate?]. 200312825583
[sars genome deciphered]. 200312828178
[will a vaccine save us from sars?]. 200312830249
[sars--the merciless test of preparedness]. 200312830275
sars: an emerging global disease with a local impact. 200312830677
health is a global issue. 200312835748
sars outbreak in the philippines. 200312836452
sars--a fast moving infectious disease. 200312836636
[recommendations on corticosteroid therapy in patients with severe acute respiratory syndrome]. 200312837159
[clinical investigation of outbreak of nosocomial severe acute respiratory syndrome].to summarize and analyze the clinical manifestation, diagnosis and therapeutic strategy of severe acute respiratory syndrome (sars), and its characteristics of outbreak in hospital via infection transmission cluster associated with sars patients.200312837162
from the centers for disease control and prevention. update: severe acute respiratory syndrome-- united states, june 11, 2003. 200312837704
global outbreak of severe acute respiratory syndrome (sars). 200312839707
severe acute respiratory syndrome (sars).several cases of life threatening respiratory disease with no identifiable cause were reported from guangdong province, china; these were soon followed by reports from many other countries. the disease was named as severe acute respiratory syndrome (sars). a novel coronavirus, isolated from the respiratory secretions of patients, has been implicated in the causation of sars. the modes of transmission include droplet spread, close contact, and fomites; shedding of virus from respiratory tract is ...200312841401
sars: lessons learned thus far. 200312841969
update: severe acute respiratory syndrome--united states, 2003.cdc continues to work with state and local health departments, the world health organization (who), and other partners to investigate cases of severe acute respiratory syndrome (sars). this report updates reported sars cases worldwide and in the united states, and summarizes changes in travel recommendations for beijing and taiwan, where travel advisories have been downgraded to travel alerts.200312844079
a new recruit for the army of the men of death.the army of the men of death, in john bunyan's memorable phrase, has a new recruit, and fear has a new face: a face wearing a surgical mask.200312844350
the effect of sars coronavirus on blood system: its clinical findings and the pathophysiologic hypothesis.severe acute respiratory syndrome (sars) has recently recognized as a new human infectious disease. a novel coronavirus was identified as the causative agent of sars. this report summarizes the hematological findings in sars patients and proposes a hypothesis for the pathophysiology of sars coronavirus related abnormal hematopoiesis. hematological changes in patients with sars were common and included lymphopenia (68% - 90% of adults; 100% of children, n = 10), thrombocytopenia (20% - 45% of adu ...200312844398
sars genome chip available to scientists: the niaid hopes that widespread access to the sars genome chip will catalyse research into effective treatments for the virus. 200312846246
severe acute respiratory syndrome (sars). 200312846882
severe acute respiratory syndrome. 200312847831
[study on the epidemiological characteristics of severe acute respiratory syndrome in shanxi province].to describe the epidemiological characteristics and related factors of sars in shanxi in order to provide scientific basis for prevention and control of severe acute respiratory syndrome (sars).200312848908
[the application of indirect immuno-fluorescence assay in the diagnosis of severe acute respiratory syndrome].to explore the temporal profile of serum antibody against coronavirus in patients with severe acute respiratory syndrome (sars), and to evaluate the reliability of indirect immuno-fluorescence assay (ifa) in the diagnosis of sars.200312848915
coronavirus genomic-sequence variations and the epidemiology of the severe acute respiratory syndrome. 200312853594
sars: what have we learned? 200312853923
zcurve_cov: a new system to recognize protein coding genes in coronavirus genomes, and its applications in analyzing sars-cov genomes.a new system to recognize protein coding genes in the coronavirus genomes, specially suitable for the sars-cov genomes, has been proposed in this paper. compared with some existing systems, the new program package has the merits of simplicity, high accuracy, reliability, and quickness. the system zcurve_cov has been run for each of the 11 newly sequenced sars-cov genomes. consequently, six genomes not annotated previously have been annotated, and some problems of previous annotations in the rema ...200312859968
identification of an epitope of sars-coronavirus nucleocapsid protein.the nucleocapsid (n) protein of severe acute respiratory syndrome-coronavirus (sars-cov) is a major virion structural protein. in this study, two epitopes (n1 and n2) of the n protein of sars-cov were predicted by bioinformatics analysis. after immunization with two peptides, the peptides-specific antibodies were isolated from the immunized rabbits. the further experiments demonstrated that n1 peptide-induced polyclonal antibodies had a high affinity to bind to e. coli expressed n protein of sar ...200312862314
[antibody response of patients with severe acute respiratory syndrome (sars) to nucleocapsid antigen of sars-associated coronavirus].to assess serum antibody responses of patients with severe acute respiratory syndrome (sars) to nucleocapsid (n) antigen of sars-associated coronavirus.200312865207
rapid and efficient preparation of monoclonal antibodies against sars-associated coronavirus nucleocapsid protein by immunizing mice.to develop a rapid and efficient method for preparing monoclonal antibodies (mab) against sars-associated coronavirus (sars-cov) nucleocapsid (n) protein.200312865208
severe acute respiratory syndrome (sars): breath-taking progress.reports of a new severe respiratory disease, now defined as severe acute respiratory syndrome (sars), began to emerge from guangdong, in southern china, in late 2002. the condition came to international attention through an explosive outbreak in hong kong in march 2003. cases appeared throughout south-east asia and in toronto, the spread of sars being accelerated by international air travel. a global emergency was declared by the world health organization, bringing together an international team ...200312867552
description and clinical treatment of an early outbreak of severe acute respiratory syndrome (sars) in guangzhou, pr china.severe acute respiratory syndrome (sars), now known to be caused by a coronavirus, probably originated in guangdong province in southern china in late 2002. the first major outbreak occurred in guangzhou, the capital of guangdong, between january and march 2003. this study reviews the clinical presentation, laboratory findings and response to four different treatment protocols. case notes and laboratory findings were analysed and outcome measures were collected prospectively. the sars outbreak i ...200312867568
[severe acute respiratory syndrome: the first transmissible disease of the 21st century].the severe acute respiratory syndrome (sars) is the first severe and easily transmissible disease to emerge in the 21st century. it is caused by the infection with a coronavirus, a single strand rna capsulated virus, recently found in a small mammalian, the masked palm civet. it is likely to represent the source of human infection. the first cases of sars have been reported in the chinese province of guangdong and, since then, probable cases have been reported world wide. the clinical picture is ...200312868234
sars in china. china's missed chance. 200312869735
sars in china. tracking the roots of a killer. 200312869736
sars in china. the big question now: will it be back? 200312869737
hong kong sars sequence. 200312869741
update: severe acute respiratory syndrome--worldwide and united states, 2003.this report updates reported cases of severe acute respiratory syndrome (sars) worldwide and in the united states, describes a change in the recommended timing of collection of a convalescent-phase serum specimen to test for antibody to sars-associated coronavirus (sars-cov), and introduces a new case exclusion criterion based on negative sars-cov serology. in addition, this report also summarizes changes in travel alerts for beijing and mainland china, hong kong, toronto, and taiwan.200312869906
[identification and molecular cloning and sequence analysis of a novel coronavirus from patients with sars by rt-pcr].to investigate the etiologic agents of the sars and develop diagnostic method for this disease.200312869994
severe acute respiratory syndrome (sars): an interim information paper for dental health care workers. 200312873106
the complete genome sequence of severe acute respiratory syndrome coronavirus strain hku-39849 (hk-39).the complete genomic nucleotide sequence (29.7kb) of a hong kong severe acute respiratory syndrome (sars) coronavirus (sars-cov) strain hk-39 is determined. phylogenetic analysis of the genomic sequence reveals it to be a distinct member of the coronaviridae family. 5' race assay confirms the presence of at least six subgenomic transcripts all containing the predicted intergenic sequences. five open reading frames (orfs), namely orf1a, 1b, s, m, and n, are found to be homologues to other cov mem ...200312876307
guest editorial. 200312880749
[ultrastructural characteristics of sars associated virus in infected cells].electron microscopical study of infected cells to identify the pathogenic agent of sars.200312882683
[gene detection of severe acute respiratory syndrome-related coronavirus].to develop a newly real-time rt-polymerase chain reaction assay for severe acute respiratory syndrome (sars) related coronavirus in human whole blood.200312882684
[gene detection of severe acute respiratory syndrome-related coronavirus].to develop a newly real-time rt-polymerase chain reaction assay for severe acute respiratory syndrome (sars) related coronavirus in human whole blood.200312882684
the search for a practical approach to emerging diseases: the case of severe acute respiratory syndrome (sars). 200212885151
sars: just another viral acronym?recent observations and experimental evidence have purported that a virus causes sars, but such viruses have been isolated in only less than half of sars patients in some studies and virologist vincent plummer of winnipeg's national microbiology laboratory found that indeed 1 in 5 perfectly healthy canadians with a history of recent travel to asia had the virus. therefore sars microbiologic origins remain unclear. outbreaks of multi-drug resistant (mdr) tuberculosis and the atypical mycobacteria ...200312888325
protecting against sars during equipment maintenance.the recent outbreak of severe acute respiratory syndrome (sars) raises questions about the appropriate infection control measures to use when conducting maintenance procedures on medical devices that may have been exposed to the sars virus--that is, devices that have been used on, or located in the same room as, a patient with (or suspected to have) sars. although there is considerable information and guidance available on many aspects of sars, very little exists on this particular topic. what's ...200312889257
mechanical ventilation of sars patients. safety issues involving breathing-circuit filters.patients suffering from severe acute respiratory syndrome (sars) sometimes require mechanical ventilation. this raises safety concerns about the sars virus being carried by droplets that exit from the exhalation limb of the ventilator. ecri recommends that breathing-circuit filters be incorporated in the exhalation limb of any ventilator used on a patient with sars. in this article, we review the issues behind our recommendations and describe steps hospitals can take to prevent any adverse effec ...200312889258
establishment of a fluorescent polymerase chain reaction method for the detection of the sars-associated coronavirus and its clinical application.to establish a fluorescent polymerase chain reaction (f-pcr) method for detecting the coronavirus related to severe acute respiratory syndrome (sars) and to evaluate its value for clinical application.200312890368
binding mechanism of coronavirus main proteinase with ligands and its implication to drug design against sars.in order to stimulate the development of drugs against severe acute respiratory syndrome (sars), based on the atomic coordinates of the sars coronavirus main proteinase determined recently [science 13 (may) (2003) (online)], studies of docking kz7088 (a derivative of ag7088) and the avlqsgfr octapeptide to the enzyme were conducted. it has been observed that both the above compounds interact with the active site of the sars enzyme through six hydrogen bonds. also, a clear definition of the bindi ...200312890493
profile of specific antibodies to the sars-associated coronavirus. 200312890855
severe acute respiratory syndrome (sars) virus. 200312892053
newly discovered coronavirus as the primary cause of severe acute respiratory syndrome.the worldwide outbreak of severe acute respiratory syndrome (sars) is associated with a newly discovered coronavirus, sars-associated coronavirus (sars-cov). we did clinical and experimental studies to assess the role of this virus in the cause of sars.200312892955
[sars, possible zoonosis in the area of conflict of pathogenic coronaviruses of animals].severe acute respiratory syndrome (sars) is an emerging disease, which was first recognized in guangdong province, china, in november 2002. in the meantime, sars has been recognized in patients on all five continents. a novel coronavirus, which is not related to the hitherto known coronaviruses, has been proven to be associated with the disease. our genomic analyses strongly suggest that the new sars-coronavirus did not emerge through mutation or recombination and that it has probably been trans ...200312894604
[expression and purification of recombinant sars coronavirus spike protein].a novel coronavirus (sars-coronavirus, sars-cov) was discovered in association with cases of severe acute respiratory syndrome (sars) recently. the first step in coronavirus infection is binding of the viral spike protein to certain receptor on host cells. the spike protein is the main surface antigen of the coronavirus and there should be antibodies against spike protein in patients serum. thus, to develop and expression protein fragment from spike protein gene are the purposes of this experime ...200312897976
[clinical analysis of 190 cases of outbreak with atypical pneumonia in guangzhou in spring, 2003].to study methods of diagnosis and treatment for atypical pneumonia (severe acute respiratory syndrome), outbreak of the illness in guangzhou during jan. - mar., 2003.200312899744
[serum antibodies detection for serological diagnosis of severe acute respiratory syndrome].to evaluate the significance of serum specific antibodies against severe acute respiratory syndrome (sars) virus in the diagnosis of sars and the concordance of ifa and elisa in the antibodies measurements.200312899765
mutation analysis of 20 sars virus genome sequences: evidence for negative selection in replicase orf1b and spike gene.recently, more sars-cov virus genome sequences are released to the genbank database. the aim of this study is to reveal the evolution forces of sars-cov virus by analyzing the nucleotide mutations in these sequences.200312904271
[detection of sars-cov rna in stool samples of sars patients by nest rt-pcr and its clinical value].to investigate of severe acute respiratory syndrome (sars) convalescent stool shedding by rt-pcr.200312905760
sars genome patent: to manage and to share. 200312907024
panspermia--true or false? 200312907026
panspermia--true or false? 200312907028
['severe acute respiratory syndrome' (sars): epidemiology, clinical signs, diagnosis and prevention].severe acute respiratory syndrome (sars) is caused by a recently identified coronavirus (sars-cov). the clinical symptoms are non-specific and during the first few days in particular, are not clinically distinguishable from those of many other viral or bacterial infections. the majority of infected patients develop pneumonia within a week of the first symptoms appearing. since november 2002 the virus has spread from south china to almost 30 other countries, where about 8500 infected individuals ...200312908346
management of severe acute respiratory syndrome: the hong kong university experience. 200312912734
severe acute respiratory syndrome (sars): a review of the history, epidemiology, prevention, and concerns for the future.during the first part of 2003, the world experienced the first epidemic of the 21st century with the emergence of a new and readily transmissible disease. the disease, severe acute respiratory syndrome (sars), spread quickly and caused numerous deaths, as well as public panic. this article provides a brief review of the initial history of the epidemiology, as well as of the clinical definition, occurrence in the pediatric population, etiology, prevention, drug studies, and considerations for the ...200312913837
[characterization of severe acute respiratory syndrome outbreak and identification of novel coronavirus]. 200312913999
[summary of the corss-strait seminar on prevention and control of sars]. 200312914000
[the research progress in the etiological factor and the assay of sars]. 200312914004
[primary investigation on the changing mode of plasma specific igg antibody in sars patients and their physicians and nurses].to primarily investigate the changing mode of anti-sars coronavirus igg antibody in clinically diagnosed sars patients and the possibility of subclinical infection in physicians and nurses through close association with sars patients.200312914210
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