| inhibitory effects of the standardized extract of phyllanthus amarus on cellular and humoral immune responses in balb/c mice. | phyllanthus amarus has been shown to have strong inhibitory effects on phagocytic activity of human neutrophils and on cellular immune responses in wistar-kyoto rats. in this study, we investigated the effects of daily treatment of standardized extract of p. amarus at 50, 100 and 200 mg/kg for 14 days in balb/c mice by measuring the myeloperoxidase activity (mpo), nitric oxide (no) release, macrophage phagocytosis, swelling of footpad in delayed type hypersensitivity (dth), and serum immunoglobu ... | 2016 | 27137750 |
| immunosuppressive effects of the standardized extract of phyllanthus amarus on cellular immune responses in wistar-kyoto rats. | phyllanthus amarus (family: euphorbiaceae) is of immense interest due to its wide spectrum of biological activities. in the present study, the standardized 80% ethanol extract of p. amarus was investigated for its modulatory activity on various cellular immune parameters, including chemotaxis of neutrophils, engulfment of escherichia coli by neutrophils, and mac-1 expression, in leukocytes isolated from treated/nontreated wistar-kyoto rats. the detailed cell-mediated activity of p. amarus was al ... | 2015 | 26347462 |
| alpha-amylase inhibitory activity of some malaysian plants used to treat diabetes; with particular reference to phyllanthus amarus. | extracts of six selected malaysian plants with a reputation of usefulness in treating diabetes were examined for alpha-amylase inhibition using an in vitro model. inhibitory activity studied by two different protocols (with and without pre-incubation) showed that phyllanthus amarus hexane extract had alpha-amylase inhibitory properties. hexane and dichloromethane extracts of anacardium occidentale, lagerstroemia speciosa, averrhoa bilimbipithecellobium jiringa and parkia speciosa were not active ... | 2006 | 16678367 |
| the treatment of jaundice with medicinal plants in indigenous communities of the sub-himalayan region of uttarakhand, india. | inspite of tremendous advances made in allopathic medical practices, herbs still play an important role in the management of various liver diseases. a large number of plants and formulations have been claimed to have hepatoprotective activity. jaundice is a symptom, indicative of the malfunctioning of the liver. this paper provides ethnomedicinal information on the plants used to treat jaundice by three important indigenous communities, i.e., nomadic gujjars, tharu and bhoxa of sub-himalayan reg ... | 2012 | 22759701 |
| phyllanthin of standardized phyllanthus amarus extract attenuates liver oxidative stress in mice and exerts cytoprotective activity on human hepatoma cell line. | phyllanthus amarus, a traditional herbal liver-protecting medicine, is known to contain an active ingredient phyllanthin. many research studies and clinical trials performed in the past using this plant have given contentious results which clearly accentuates the need for the standardization of the extracts. | 2011 | 25755316 |
| the lignan niranthin poisons leishmania donovani topoisomerase ib and favours a th1 immune response in mice. | niranthin, a lignan isolated from the aerial parts of the plant phyllanthus amarus, exhibits a wide spectrum of pharmacological activities. in the present study, we have shown for the first time that niranthin is a potent anti-leishmanial agent. the compound induces topoisomerase i-mediated dna-protein adduct formation inside leishmania cells and triggers apoptosis by activation of cellular nucleases. we also show that niranthin inhibits the relaxation activity of heterodimeric type ib topoisome ... | 2012 | 23027614 |
| assessment of functional and genetic diversity of aerobic endospore forming bacilli from rhizospheric soil of phyllanthus amarus l. | fifty two aerobic and endospore forming bacilli (aefb) strains were recovered from rhizospheric soil of phyllanthus amarus. morphological, biochemical and molecular characterization by 16s rdna gene sequencing has shown that these bacterial strains belong to six different genera of aefb i.e. bacillus, brevibacillus, lysinibacillus, paenibacillus, terribacillus and jeotgalibacillus. analysis of their pgp activities has shown that 92.30 % strains produced indole acetic acid hormone, 86.53 % of the ... | 2013 | 23526192 |
| antimalarial plant remedies from burkina faso: their potential for prophylactic use. | saye, a combination remedy prepared from cochlospermum planchonii hook.f. (cochlospermaceae), cassia alata l. (fabaceae) and phyllanthus amarus schumach. et thonn. (euphorbiaceae), n'dribala, a cochlospermum planchonii root decoction, and a fruit preparation of azadirachta indica a. juss. (meliaceae) are plant remedies of the folk medicine in burkina faso and are commonly used by traditional healers for the treatment of malaria. | 2012 | 22301449 |
| antimalarial activities of medicinal plants traditionally used in the villages of dharmapuri regions of south india. | an ethnopharmacological investigation of medicinal plants traditionally used to treat diseases associated with fevers in dharmapuri region of south india was undertaken. twenty four plants were identified and evaluated for their in vitro activity against plasmodium falciparum and assessed for cytotoxicity against hela cell line. | 2012 | 22433533 |
| herbal medicines as diuretics: a review of the scientific evidence. | there is increasing interest in the health and wellness benefits of herbs and botanicals. this is with good reason as they might offer a natural safeguard against the development of certain conditions and be a putative treatment for some diseases. one such area may be the lowering of blood pressure in those where it is elevated (i.e., hypertension). one class of clinical medicines used to lower blood pressure are known as diuretics and work by increasing the excretion of urine from the body as w ... | 2007 | 17804183 |
| determination of element contents in herbal drugs: chemometric approach. | the elemental content of 23 commercial herbal drugs was evaluated and multivariate analysis such as principal component analysis (pca) and hierarchical cluster analysis (hca) were performed with aim to know the relationship among the elements in the herbal drugs. among the 13 elements investigated k (8096.97), na (581.53), cu (2.06); mg (678.4); fe (476.93), al (321.5), co (0.22); zn (4.46), ni (0.56); mn (25.77); pb (13.33); and cr (13.18)mg/kg dry weight, respectively, were found at high conce ... | 2012 | 22980815 |
| screening for potential α-glucosidase and α-amylase inhibitory constituents from selected vietnamese plants used to treat type 2 diabetes. | the 18 plant species investigated in this study have been used as herbal antidiabetic remedies in vietnamese traditional medicines. this study aimed to evaluate their ability to inhibit α-glucosidase and α-amylase, two key enzymes involved in serum glucose regulation. | 2016 | 27041401 |
| green silver nanoparticles of phyllanthus amarus: as an antibacterial agent against multi drug resistant clinical isolates of pseudomonas aeruginosa. | pseudomonas aeruginosa infection is a leading cause of morbidity and mortality in burn and immune-compromised patients. in recent studies, researchers have drawn their attention towards ecofriendly synthesis of nanoparticles and their activity against multidrug resistant microbes. in this study, silver nanoparticles were synthesized from aqueous extract of phyllanthus amarus. the synthesized nanoparticles were explored as a potent source of nanomedicine against mdr burn isolates of p. aeruginosa ... | 2014 | 25271044 |
| antifungal activity of nor-securinine against some phytopathogenic fungi. | crude extracts and active principles from medicinal plants have shown potential role in controlling plant diseases in glasshouses as well as in fields as one of the safest and ecofriendly methods. the effect of nor-securinine (an alkaloid) isolated from phyllanthus amarus has been seen against spore germination of some fungi (alternaria brassicae, a. solani, curvularia pennisetti, curvularia sp., erysiphe pisi, helminthosporium frumentacei) as well as pea powdery mildew (erysiphe pisi) under gla ... | 2005 | 24049481 |
| why urban citizens in developing countries use traditional medicines: the case of suriname. | the use of traditional medicines (tms) among urban populations in developing countries and factors underlying people's decision to use tms are poorly documented. we interviewed 270 adults in paramaribo, suriname, using a stratified random household sample, semistructured questionnaires, and multivariate analysis. respondents mentioned 144 medicinal plant species, most frequently gossypium barbadense, phyllanthus amarus, and quassia amara. 66% had used tms in the previous year, especially people ... | 2013 | 23653663 |
| preclinical screening of phyllanthus amarus ethanolic extract for its analgesic and antimicrobial activity. | to discover a new agent which possesses dual property of analgesic and antimicrobial activity, thereby reducing the burden of polypharmacy. phyllanthus amarus was screened for its analgesic and antimicrobial activities. | 2017 | 26692753 |
| potential effect of herbs on diabetic hypertension: alternative medicine treatment modalities. | diabetes mellitus is commonly known to lead to life threatening complications. among them, hypertension is one complication which may be highlighted. in modern medical society, several drugs and treatment regimen have developed to treat diabetes mellitus. although they obtain positive impacts, yet there are certain limitations encountered in the management of the disease due to their adverse effects and non-compliance by the patients. herbs have been valued as a supplement in treating chronic ox ... | 2013 | 24424219 |
| a pharmacological appraisal of medicinal plants with antidiabetic potential. | diabetes mellitus is a complicated metabolic disorder that has gravely troubled the human health and quality of life. conventional agents are being used to control diabetes along with lifestyle management. however, they are not entirely effective and no one has ever been reported to have fully recovered from diabetes. numerous medicinal plants have been used for the management of diabetes mellitus in various traditional systems of medicine worldwide as they are a great source of biological const ... | 2012 | 22368396 |
| activated charcoal-mediated rna extraction method for azadirachta indica and plants highly rich in polyphenolics, polysaccharides and other complex secondary compounds. | high quality rna is a primary requisite for numerous molecular biological applications but is difficult to isolate from several plants rich in polysaccharides, polyphenolics and other secondary metabolites. these compounds either bind with nucleic acids or often co-precipitate at the final step and many times cannot be removed by conventional methods and kits. addition of vinyl-pyrollidone polymers in extraction buffer efficiently removes polyphenolics to some extent, but, it failed in case of a ... | 2013 | 23537338 |
| arsenic accumulation in native plants of west bengal, india: prospects for phytoremediation but concerns with the use of medicinal plants. | arsenic (as) is a widespread environmental and food chain contaminant and class i, non-threshold carcinogen. plants accumulate as due to ionic mimicry that is of importance as a measure of phytoremediation but of concern due to the use of plants in alternative medicine. the present study investigated as accumulation in native plants including some medicinal plants, from three districts [chinsurah (hoogly), porbosthali (bardhman), and birnagar (nadia)] of west bengal, india, having a history of a ... | 2012 | 21713498 |
| streptomyces phyllanthi sp. nov., isolated from the stem of phyllanthus amarus. | the novel endophytic actinomycete strain pa1-07t was isolated from the stem of phyllanthus amarus. the strain displayed the consistent characteristics of members of the genus streptomyces. the strain produced short spiral spore chains on aerial mycelia. it grew at ph 5-9, at 40 °c and with a maximum of 5 % (w/v) nacl. it contained ll-diaminopimelic acid, glucose and ribose in the whole-cell hydrolysate. the major cellular menaquinones were mk-9(h4), mk-9(h6) and mk-9(h8), while the major cellula ... | 2016 | 27393329 |