| immunological response to (1,4)-alpha-d-glucan in the lung and spleen of endotoxin-stimulated juvenile rats. | we investigated the effects of (1,4)-alpha-d-glucan (alpha-dg), a novel immune stimulatory drug from tinospora cordifolia, on the concentration of pro- and anti-inflammatory cytokines (interleukin [il]-1beta, il-6, tumour necrosis factor-alpha [tnf-alpha], gamma-interferon [ifn-gamma] and il-10) in the lung and spleen of endotoxin-stimulated juvenile rats. experimental groups (n = 16/group) included controls with an intraperitoneal injection of saline, endotoxaemic rats with a non-lethal dose of ... | 2009 | 19627280 |
| synthesis of pediculocidal and larvicidal silver nanoparticles by leaf extract from heartleaf moonseed plant, tinospora cordifolia miers. | insecticide resistance and inadequate attention to the application instructions of topical pediculicides are common reasons for treatment failure. essential oils or plant extracts are good and safe alternatives due to their low toxicity to mammals and easy biodegradability. the present study was carried out to establish the pediculocidal and larvicidal activity of synthesized silver nanoparticles (agnps) using leaf aqueous extract of tinospora cordifolia miers (menispermaceae) against the head l ... | 2011 | 21212979 |
| radiation-induced testicular injury and its amelioration by tinospora cordifolia (an indian medicinal plant) extract. | the primary objective of this investigation is to determine the deleterious effects of sub lethal gamma radiation on testes and their possible inhibition by tinospora cordifolia extract (tce). for this purpose, one group of male swiss albino mice was exposed to 7.5?gy gamma radiation to serve as the irradiated control, while the other group received tce (75?mg/kg?b.?wt./day) orally for 5 consecutive days half an hr before irradiation to serve as experimental. exposure of animals to 7.5?gy gamma ... | 2011 | 21350610 |
| evidences for the involvement of monoaminergic and gabaergic systems in antidepressant-like activity of tinospora cordifolia in mice. | the present study was taken up to investigate the effect of petroleum ether extract of tinospora cordifolia (wild.) miers, on depression in mice. the extract (50, 100 and 200 mg/kg, p.o.) was administered for 14 successive days to swiss young albino mice (either sex) and evaluated for antidepressant-like activity using tail suspension test and forced swim test. petroleum ether extract at all three doses produced significant antidepressant-like effect in tail suspension test as well as in forced ... | 2008 | 21369437 |
| tinospora cordifolia attenuates oxidative stress and distorted carbohydrate metabolism in experimentally induced type 2 diabetes in rats. | diabetes is a chronic metabolic disorder affecting a vast number of people worldwide. oxidative stress is the causative agent amplifying diabetic complications in various organs by generating noxious amount of free radicals. a huge interest always exists in exploring nutraceuticals from plant materials to replace synthetic drugs in order to overcome their adverse effects and also for economic reasons. the anti-diabetic efficiency of a medicinal plant, tinospora cordifolia (tc) was studied in exp ... | 2011 | 21538233 |
| profile of aldose reductase inhibition, anti-cataract and free radical scavenging activity of selected medicinal plants: an attempt to standardize the botanicals for amelioration of diabetes complications. | phytotherapy has played an important role in the management of diabetes and related complications. in the present study different fractions of catharanthus roseus l. (apocynaceae), ocimum sanctum l. (labiatae), tinospora cordifolia willd. (menispermaceae), aegle marmelos l. (rutaceae), ficus golmerata l. (moraceae), psoralea corlifolia l. (fabaceae), tribulus terrestris l. (zygophyllaceae), and morinda cetrifolia l. (rubiaceae) were evaluated as possible inhibitors of aldose reductase (ar: a key ... | 2011 | 21570444 |
| hypoglycemic activity of alkaloidal fraction of tinospora cordifolia. | the stem of tinospora cordifolia (tc) is widely used in the therapy of diabetes in traditional folk medicine of india. in the present study, isoquinoline alkaloid rich fraction (aftc) derived from stem of tc and three alkaloids viz., palmatine, jatrorrhizine and magnoflorine were evaluated for insulin-mimicking and insulin-releasing effect in vitro and in vivo. their effect on hepatic gluconeogenesis was examined in rat hepatocytes. insulin releasing effect was detected in vitro using rat pancre ... | 2011 | 21665451 |
| evaluation of antidiabetic and related actions of some indian medicinal plants in diabetic rats. | to evaluate antidiabetic activity of chloroform extracts of acacia arabica bark, benincasa hispida fruit, tinispora cordifolia stem, ocimum sanctum areal parts and jatropha curcus leaves. | 2011 | 21771409 |
| induction of caspase-3 activated dnase mediated apoptosis by hexane fraction of tinospora cordifolia in eat cells. | tinospora cordifolia (guduchi) has been used for centuries for treating various ailments including cancer in ayurvedic system of medicine. in this study, we report the mechanism of cell death exhibited by the hexane extract fraction of t. cordifolia (tchf) against ehrlich ascites tumor (eat) in mice. treatment of eat bearing animals with tchf resulted in growth inhibition and induction of apoptosis in a dose-dependent manner. tchf induced the formation of apoptotic bodies, nuclear condensation, ... | 2007 | 21783760 |
| immunostimulatory properties of the major protein from the stem of the ayurvedic medicinal herb, guduchi (tinospora cordifolia). | guduchi (tinospora cordifolia), a widely used plant in folk and ayurvedic systems of medicine is well known for its immunomodulatory activity; however, the presence of an immunomodulatory protein (imp) in guduchi has not been investigated. | 2011 | 22119223 |
| abrogation of maternal and fetal oxidative stress in the streptozotocin-induced diabetic rat by dietary supplements of tinospora cordifolia. | objective: diabetes during pregnancy increases the incidences of congenital anomalies, morbidity, and mortality in the mother and her fetus/newborn. oxidative stress (os) has been implicated to be responsible because various antioxidants have been demonstrated to be beneficial in diabetic embryopathy. in this study, we examined the propensity of tinospora cordifolia (tc) to attenuate embryopathy and os in pregnant diabetic rats. methods: pregnant rats were rendered diabetic with streptozotocin ( ... | 2011 | 22189193 |
| antipyretic activity of guduchi ghrita formulations in albino rats. | the present pharmacological investigation was undertaken to study the anti-pyretic activity of guduchi ghrita formulations in albino rats against yeast induced pyrexia. seven groups of six animals were used for the experiment. the yeast induced pyrexia method was standardized first by injecting 12.5% yeast suspension (s.c) followed by recording the rectal temperature at regular intervals. then the evaluation of anti-pyretic activity of guduchi ghrita formulations was carried out by using this st ... | 2010 | 22131741 |
| effect of aqueous extract of tinospora cordifolia on functions of peritoneal macrophages isolated from ccl4 intoxicated male albino mice. | the current practice of ingesting phytochemicals for supporting the immune system or fighting infections is based on centuries-old tradition. macrophages are involved at all the stages of an immune response. the present study focuses on the immunostimulant properties of tinospora cordifolia extract that are exerted on circulating macrophages isolated from ccl(4) (0.5 ml/kg body weight) intoxicated male albino mice. | 2011 | 22035196 |
| clinical evaluation of shilajatu rasayana in patients with hiv infection. | aids is one of the serious global health concerns caused by human immuno deficiency(hiv) virus and is predominantly a sexually transmitted disease. currently there is no vaccine or cure for aids still anti retroviral therapy (art) is successful. it reduces both the mortality and the morbidity of hiv infection, but is expensive and inaccessible in many countries. however intense the therapy may be, hiv virus is rarely eliminated, and drug resistance is a major setback during long-term therapy. th ... | 2010 | 22131681 |
| Antibacterial activity of selected medicinal plants against multiple antibiotic resistant uropathogens: a study from Kolli Hills, Tamil Nadu, India. | The increasing incidence of antibiotic resistance among bacterial pathogens necessitates medicinal plants as an alternate therapy in restricting the resistant infectious organisms. In this primitive study, the antibiotic resistance of organisms isolated from urinary tract infected patients was evaluated using the National Committee for Clinical Laboratory Standards (NCCLS) method and Multiple Antibiotic Resistance (MAR) index values, and the MAR values was also calculated for plant extracts. The ... | 2011 | 21986363 |
| antipsychotic activity of aqueous ethanolic extract of tinospora cordifolia in amphetamine challenged mice model. | tinospora cordifolia is reported to have cns active principle and is used for the treatment of various neurological disorders. hence, the effect of aqueous ethanolic extract of tinospora cordifolia was investigated for its putative antipsychotic activity using amphetamine challenged mice model. haloperidol (1 mg/kg i.p.) was administered acutely to mice as standard drug. control animals received vehicle (10% dmso). the in vivo receptor binding studies were carried out to correlate the antipsycho ... | 2010 | 22247829 |
| medico - botanical study of yercaud hills in the eastern ghats of tamil nadu, india. | the study reports medicinal plant survey was conceded in yercaud hills ranges of eastern ghats, tamil nadu, india. the study primarily based on field surveys conducted throughout the hills, where dwellers provided information on plant species used as medicine, plant parts used to prepare the remedies and ailments to which the remedies were prescribed. the study resulted about 48- plant species belonging to 45- genera and 29- families of medicinal plants related to folk medicine used by the local ... | 2011 | 22557438 |
| evaluation of anti-depressant and anxiolytic activity of rasayana ghana tablet (a compound ayurvedic formulation) in albino mice. | in recent years, many ayurvedic formulations are being researched to provide an effective antidepressant and anxiolytic drug in the field of psycho-pharmacology. the present study was planned to evaluate the anti-depressant and anxiolytic activity of rasayana ghana tablet comprising three herbs guduchi (tinospora cordifolia miers), aamalaki (emblica officinalis garten) (rgt) and gokshura (tribulus terrestris linn). swiss albino mice were divided into four groups of six animals each, comprising o ... | 2011 | 22529654 |
| tinospora cordifolia: one plant, many roles. | natural products with medicinal value are gradually gaining importance in clinical research due to their well-known property of no side effects as compared to drugs. tinospora cordifolia commonly named as "guduchi" is known for its immense application in the treatment of various diseases in the traditional ayurvedic literature. recently the discovery of active components from the plant and their biological function in disease control has led to active interest in the plant across the globe. our ... | 2012 | 23661861 |
| application of the kombucha 'tea fungus' for the enhancement of antioxidant and starch hydrolase inhibitory properties of ten herbal teas. | ten herbal teas (acacia arabica, aegle marmelos flower, a. marmelos root bark, aerva lanata, asteracantha longifolia, cassia auriculata, hemidesmus indicus, hordeum vulgare, phyllanthus emblica, tinospora cordifolia) were fermented with the kombucha 'tea fungus'. the ph values of the fermented beverages ranged from 4.0 to 6.0 by day 7, while the titratable acidity ranged from 2.5 to 5.0g/ml (p<0.05). gallic acid had statistically significantly increased (p<0.05) in almost all the samples by day ... | 2016 | 26471559 |
| attenuation of quorum sensing-regulated behaviour by tinospora cordifolia extract & identification of its active constituents. | the pathogenicity of the nosocomial pathogens, pseudomonas aeruginosa and acinetobacter baumannii is regulated by their quorum sensing (qs) systems. the objective of the present study was to examine the effect of the cold ethyl acetate extract of tinospora cordifolia stem on virulence and biofilm development in the wild type and clinical strains of p. aeruginosa and a. baumannii. the study was further aimed to identify the probable active constituents in the plant extract. | 2016 | 27834332 |
| season and tissue type affect fungal endophyte communities of the indian medicinal plant tinospora cordifolia more strongly than geographic location. | a total of 1,151 endophytic fungal isolates representing 29 taxa were isolated from symptom-less, surface-sterilized segments of stem, leaf, petiole, and root of tinospora cordifolia which had been collected at three locations differing in air pollution in india (ramnagar, banaras hindu university, maruadih) during three seasons (summer, monsoon, winter). endophytes were most abundant in leaf tissues (29.38% of all isolates), followed by stem (18.16%), petiole (10.11%), and root segments (6.27%) ... | 2012 | 22430503 |
| bactericidal activity of selected medicinal plants against multidrug resistant bacterial strains from clinical isolates. | to investigate the antibacterial effect of curcuma longa (c. longa), zingiber officinale (z. officinale) and tinospora cordifolia (t. cordifolia) against staphylococcus aureus, pseudomonas aeruginosa, klebsiella pneumoniae, escherichia coli, bacillus subtilis and proteus mirabilis of clinical origin. | 2014 | 25312164 |
| ethanolic extracts of tinospora cordifolia and alstonia scholaris show antimicrobial activity towards clinical isolates of methicillin-resistant and carbapenemase-producing bacteria. | the aim of this study was to determine the in vitro antimicrobial activity of crude extracts of three plants from ayurveda tradition (tinospora cordifolia, alstonia scholaris, crataeva nurvala) against reference microbial strains and clinical isolates of methicillin-resistant staphylococcus aureus (mrsa) and carbapenemase-producing klebsiella pneumoniae. ic50 values were obtained by micro-dilution methods meeting the requirements of the nccls standard. the cytotoxicity of the extracts was also i ... | 2014 | 24749692 |
| antioxidant and in vivo genoprotective effects of phenolic compounds identified from an endophytic cladosporium velox and their relationship with its host plant tinospora cordifolia. | tinospora cordifolia (willd. hook. f. & thomson; family: menispermaceae), has a long history of use in various traditional medicinal systems including "ayurveda". it is reported to possess anticancer, antidiabetic, antimicrobial, antispasmodic, and antiinflammatory activities. t. cordifolia has also been well documented for production of various bioactive metabolites and their antioxidant activity, but the microorganisms associated with it have been least explored for the same properties. | 2016 | 27721051 |
| insecticidal potential of an endophytic cladosporium velox against spodoptera litura mediated through inhibition of alpha glycosidases. | alpha glucosidase inhibitory activity was exhibited by partially purified fractions obtained from an endophytic cladosporium velox, isolated from tinospora cordifolia. taking into account the increasing importance of digestive enzyme inhibitors as insecticidal agents, the entomopathogenic potential of the fractions obtained was evaluated against spodoptera litura (fab.), a polyphagous pest. considerable mortality was obtained when the larvae were fed on diet supplemented with the partially purif ... | 2016 | 27265826 |
| scientific validation of the medicinal efficacy of tinospora cordifolia. | present communication reports the scientific evaluation of tinospora cordifolia for its medicinal efficacy which includes phytochemical screening, antimicrobial, antioxidant, and anticancer activities of the plant. secondary metabolites including anthraquinones, terpenoids, and saponins were present in many extracts in addition to phenolics. total phenol contents in various extracts were found in the range of 8.75-52.50 catechol equivalent per gram (ce/g). in disc diffusion assays, polar extract ... | 2013 | 24453828 |
| tinospora cordifolia as a protective and immunomodulatory agent in combination with cisplatin against murine visceral leishmaniasis. | effect of pure herb, tinospora cordifolia was studied for its hepatoprotective, nephroprotective and immunomodulatory activity against high dose cisplatin treatment in leishmania donovani infected balb/c mice. administration of cisplatin (5mg/kg b.wt. daily for 5 days, i.p.) reduced the parasite load in l. donovani infected balb/c mice but produced damage in liver and kidney as manifested biochemically by an increase in serum glutamate oxaloacetate transaminase (sgot), serum glutamate pyruvate t ... | 2014 | 24370645 |
| g1-4a, a polysaccharide from tinospora cordifolia inhibits the survival of mycobacterium tuberculosis by modulating host immune responses in tlr4 dependent manner. | rapid emergence of drug resistance in mycobacterium tuberculosis (mtb) is a major health concern and demands the development of novel adjunct immunotherapeutic agents capable of modulating the host immune responses in order to control the pathogen. in the present study, we sought to investigate the immunomodulatory effects of g1-4a, a polysaccharide derived from the indian medicinal plant tinospora cordifolia, in in-vitro and aerosol mouse models of mtb infection. g1-4a treatment of mtb infected ... | 2016 | 27148868 |
| evaluation of antiplasmodial activity of medicinal plants from north indian buchpora and south indian eastern ghats. | development of resistance against the frontline anti-malarial drugs has created an alarming situation, which requires intensive drug discovery to develop new, more effective, affordable and accessible anti-malarial agents. | 2015 | 25879738 |
| antibacterial activity of stem extracts of tinospora cordifolia (willd) hook. f & thomson. | the antibacterial activity of the aqueous, ethanol and chloroform extracts from the stems of tinospora cordifolia was studied using disc diffusion method against escherichia coil, proteus vulgaris, enterobacter faecalis, salmonella typhi (gram-negative), staphylococcus aureus and serratia marcesenses (gram-positive). results suggest that the ethanolic extract has significant antibacterial activity against tested bacteria. the present study justifies the claimed uses of tinospora cordifolia in ... | 2003 | 22557111 |
| the analgesic, anti-inflammatory and anti-pyretic activities of tinospora cordifolia. | tinospora cordifolia (t. cordifolia) is a valuable resource due to its traditional uses in the treatment of pain, fever and inflammation, but no sufficient scientific literature is available online to confirm its traditional uses in these ailments. | 2016 | 26771966 |
| radioprotective property of polysaccharide in tinospora cordifolia. | radioprotective activity of a polysaccharide preparation from the indian medicinal plant. tinospora cordifolia miers has been established using saccharomyces cerevisiae x2180 strain as the in vivo test model. the entire activity could be attributed to the radical scavenging capacity of the preparation, as it did not enhance the expression of the protective enzymes, catalase and superoxide dismutase in the yeast cells. | 2003 | 22900287 |
| ethnomedicinal plants of kathua district, j&k, india. | natural products, especially those derived from plants, continue to provide new and important leads in the drug discovery process. the first step in drug discovery is to document material traditionally used to treat an ailment. documentation of such knowledge will lead to its conservation and facilitate future research on medicinal plant safety and efficacy to validate traditional use. the present study was undertaken with an aim to document the ethnomedicinal plants of kathua district. | 2015 | 26023030 |
| preliminary screening of a classical ayurvedic formulation for anticonvulsant activity. | epilepsy is a serious and complex central nervous system disorder associated with recurrent episodes of convulsive seizures due to the imbalance between excitatory (glutamatergic) and inhibitory (gabaergic) neurotransmitters level in the brain. the available treatments are neither competent to control the seizures nor prevent progress of disease. since ages, herbal medicines have remained important sources of medicines in many parts of world which is evidenced through their uses in traditional s ... | 2017 | 28182033 |
| useful ethnophytomedicinal recipes of angiosperms used against diabetes in south east asian countries (india, pakistan & sri lanka). | this paper is based on data recorded from various literatures pertaining to ethnophytomedicinal recipes used against diabetes in south east asia (india, pakistan and srilanka). traditional plant treatments have been used throughout the world for the therapy of diabetes mellitus. in total 419 useful phytorecipes of 270 plant species belonging to 74 angiospermic families were collected. from the review it was revealed that plants showing hypoglycemic potential mainly belong to the families, cucurb ... | 2014 | 25176368 |
| radioprotective and cytoprotective activity of tinospora cordifolia stem enriched extract containing cordifolioside-a. | the present study was undertaken to evaluate the radioprotective and cytoprotective potential of cordifolioside-a, a primary active constituent of n-butanol fraction of tinospora cordifolia (nbtc) against 4 gy-γ radiation in mice and cyclophosphamide induced genotoxicity. | 2015 | 23833365 |
| a pharmacological appraisal of medicinal plants with antidiabetic potential. | diabetes mellitus is a complicated metabolic disorder that has gravely troubled the human health and quality of life. conventional agents are being used to control diabetes along with lifestyle management. however, they are not entirely effective and no one has ever been reported to have fully recovered from diabetes. numerous medicinal plants have been used for the management of diabetes mellitus in various traditional systems of medicine worldwide as they are a great source of biological const ... | 2012 | 22368396 |
| inhibition of imiquimod-induced psoriasis-like dermatitis in mice by herbal extracts from some indian medicinal plants. | psoriasis is a chronic autoimmune human skin disorder that is characterized by excessive proliferation of keratinocytes, scaly plaques, severe inflammation and erythema. the pathophysiology of psoriasis involves interplay between epidermal keratinocytes, t lymphocytes, leukocytes and vascular endothelium. increased leukocyte recruitment and elevated levels of cytokines, growth factors and genetic factors like interleukin (il)-1β, il-6, il-17, il-22, il-23, tumour necrosis factor (tnf)-α, interfe ... | 2016 | 26016607 |
| involvement of liver in diabetes mellitus: herbal remedies. | liver disease is considered as one of the major complications in oxidative stress disorders like diabetes mellitus (dm). dm presents with deterioration in carbohydrate metabolism which is characterized with chronic hyperglycemia. the organ which involves in glucose or carbohydrate metabolism and is most likely to be affected is the liver. deterioration in liver architecture and metabolism in dm, are considered as common findings. in the present review both biochemical and histological changes oc ... | 2014 | 25203338 |
| the treatment of jaundice with medicinal plants in indigenous communities of the sub-himalayan region of uttarakhand, india. | inspite of tremendous advances made in allopathic medical practices, herbs still play an important role in the management of various liver diseases. a large number of plants and formulations have been claimed to have hepatoprotective activity. jaundice is a symptom, indicative of the malfunctioning of the liver. this paper provides ethnomedicinal information on the plants used to treat jaundice by three important indigenous communities, i.e., nomadic gujjars, tharu and bhoxa of sub-himalayan reg ... | 2012 | 22759701 |
| antifertility activity of medicinal plants. | the aim of this review was to provide a comprehensive summary of medicinal plants used as antifertility agents in females throughout the world by various tribes and ethnic groups. we undertook an extensive bibliographic review by analyzing classical text books and peer reviewed papers, and further consulting well accepted worldwide scientific databases. we performed central, embase, and pubmed searches using terms such as "antifertility", "anti-implantation", "antiovulation", and "antispermatoge ... | 2015 | 25921562 |
| chemical prospection of important ayurvedic plant tinospora cordifolia by uplc-dad-esi-qtof-ms/ms and nmr. | a rapid, sensitive, and accurate ultra-performance liquid chromatography coupled with mass spectrometric method (uplc-ms) was developed and validated for simultaneous determination of four bioactive compounds, syringin (3), cordifolioside a (4), magnoflorine (6) and tinocordiside (10) in the stem of tinospora cordifolia. the analysis was performed using an acquity c18 column and gradient elution of 0.05% formic acid in water and acetonitrile at a detection wavelength of 267 nm in 5 min. a high c ... | 2015 | 25920217 |
| comparative immunomodulation potential of tinospora cordifolia (willd.) miers ex hook. f., tinospora sinensis (lour.) merrill and tinospora cordifolia growing on azadirachta indica a. juss. | guduchi has been widely used in the traditional medicine as an immunomodulator. description of guduchi in ayurvedic literature resemble with t. sinensis rather than with commonly available t. cordifolia and hence this may be used as substitutes for t. sinensis. t. cordifolia growing on azadirachta indica commonly called neem-guduchi has more immunomodulatory potential. thus, immunomodulatory activity of three tinospora spp. was assessed by checking humoral and cell mediated immune responses to t ... | 2014 | 25141544 |
| ethnoveterinary remedies of diseases among milk yielding animals in kathua, jammu and kashmir, india. | the triangle of relationship between human beings, animals and plants has existed for ages, and has given rise to intense-relationships and consequently rich traditions of ethnoveterinary knowledge throughout the world. the predominantly rural population and the strong agricultural base have provided unique situation for rich ethnoveterinary practices in the study area. | 2012 | 22366093 |
| chromatographic studies on a herb decoction. | argwadhadhi kwatham is a compound preparation of 3 single drugs viz cassia fistula l. azadirachta indica a., tinospora cordifolia l. literature survey show tat all3 ingredients are very effective for skin diseases. kahayams prepared individually with these 3 drugs was found to be more effective for skin dideases. this paper deals with a comparative study of the chemical constituents present in aragwadhadhi kwatham and the individual kwathams, all the four kwarham were chemically analysed t.l.c. ... | 1998 | 22556839 |
| ethnoveterinary study of medicinal plants in a tribal society of sulaiman range. | the aims of the present study were (i) to document ethnoveterinary plants and their formulation techniques in an unexplored region of pakistan and (ii) to select candidate medicinal plants with high consensus factor and fidelity value for further in vitro investigation. a total of 60 informants were interviewed using semistructured questionnaire. a total of 41 plants belonging to 30 families were used to treat livestock ailments in study area. mostly leaves (47%) were used in recipes formulation ... | 2014 | 25405212 |
| influence of feeding tinospora cordifolia peripartum on lactation parameters in crossbred cows. | for studying the effect of dietary supplementation of guduchi (tinospora cordifolia) peripartum on lactation an investigation was conducted on 15 pregnant karan fries crossbred cows which were divided into two groups: treatment group of eight cows which were supplemented with guduchi at 60 g/day for 45 days prepartum and 120 g/day for 45 days postpartum; control group of seven pregnant cows which were not supplemented with guduchi. jugular blood samples were collected from all cows during the pe ... | 2012 | 21895784 |
| enhanced resistance to spodoptera litura in endophyte infected cauliflower plants. | endophytic fungi, which live within host plant tissues without causing any visible symptom of disease, are important mediators of plant-herbivore interactions. these endophytes enhance resistance of host plant against insect herbivores mainly by productions of various alkaloid based defensive compounds in the plant tissue or through alterations of plant nutritional quality. two endophytic fungi, i.e., nigrospora sp. and cladosporium sp., were isolated from tinospora cordifolia (thunb.) miers, a ... | 2013 | 23575013 |
| hydroalcoholic extracts of indian medicinal plants can help in amelioration from oxidative stress through antioxidant properties. | the in vitro study of the antioxidant properties of the hydroalcoholic extracts of various indian medicinal plants can logically help to develop a better and safer way of amelioration from oxidative stress. as aimed, the present study has been done to estimate and thereby conclude regarding the antioxidant activities of a few indian medicinal plants, viz., terminalia chebula, terminalia belerica, emblica officinalis, caesalpinia crista, cajanus cajan, and tinospora cordifolia. the extracts of th ... | 2012 | 22624183 |
| effects of medhya rasayana and yogic practices in improvement of short-term memory among school-going children. | excellent memory, extraordinary intelligence, great academic achievement, and successful career are the dreams of every individual in this era of competition and professionalism. a good memory power acts as a catalyst in all walks of life, be it academic success or maintenance of personal relationships. it is observed that an average man uses only 10% of his natural memory. remaining 90% is left unused in a haphazard manner. as per the american psychologist carl emil seashore, if one is alert an ... | 2013 | 24695779 |
| analysis of glycation induced protein cross-linking inhibitory effects of some antidiabetic plants and spices. | protein cross-linking which occurs towards the latter part of protein glycation is implicated in the development of chronic diabetic complications. glycation induced protein cross-linking inhibitory effects of nine antidiabetic plants and three spices were evaluated in this study using a novel, simple, electrophoresis based method. | 2015 | 26055093 |
| berberine and its role in chronic disease. | berberine is a quaternary ammonium salt from the protoberberine group of isoquinoline alkaloids. it is found in such plants as berberis [e.g. berberis aquifolium (oregon grape), berberis vulgaris (barberry), berberis aristata (tree turmeric)], hydrastis canadensis (goldenseal), xanthorhiza simplicissima (yellowroot), phellodendron amurense ([2]) (amur corktree), coptis chinensis (chinese goldthread), tinospora cordifolia, argemone mexicana (prickly poppy) and eschscholzia californica (california ... | 2016 | 27671811 |
| anti-diabetic formulations of nāga bhasma (lead calx): a brief review. | ayurvedic formulations usually contain ingredients of herbal, mineral, metal or animal in origin. nāga bhasma (lead calx) is a potent metallic formulation mainly indicated in the treatment of prameha (~diabetes). until date, no published information is available in compiled form on the formulations containing nāga bhasma as an ingredient, their dose and indications. therefore, in the present study, an attempt has been made to compile various formulations of nāga bhasma indicated in treating pram ... | 2013 | 25161332 |
| short-term effect of g-400, polyherbal formulation in the management of hyperglycemia and hyperlipidemia conditions in patients with type 2 diabetes mellitus. | salacia oblonga, tinospora cordifolia, emblica offinalis gaertn, curcuma longa and gymnema sylvestre are ayurvedic medicinal plants reported to lower plasma glucose levels in animal models. to our knowledge, however, no clinical validations of those extracts for efficacy have been. the aim of this study was to evaluate the effect of polyherbal combination in patients with type 2 diabetes mellitus. | 2014 | 24976431 |
| do plants mediate their anti-diabetic effects through anti-oxidant and anti-apoptotic actions? an in vitro assay of 3 indian medicinal plants. | both experimental and clinical studies suggest that oxidative stress plays a major role in the pathogenesis of both types of diabetes mellitus. this oxidative stress leads to β-cell destruction by apoptosis. hence exploring agents modulating oxidative stress is an effective strategy in the treatment of both type i and type ii diabetes. plants are a major source of anti-oxidants and exert protective effects against oxidative stress in biological systems. phyllanthus emblica, curcuma longa and tin ... | 2013 | 24093976 |
| insulin sensitizing effect of 3 indian medicinal plants: an in vitro study. | measurement of glucose uptake into peripheral tissue is an important mechanism to assess insulin sensitivity. the present in vitro study was conducted to evaluate the insulin sensitizing activity of phyllanthus emblica (pe), tinospora cordifolia (tc) and curcuma longa (cl) by assessing glucose uptake activity in a 3t3l1 adipocyte model. | 2017 | 23543787 |
| clinical evaluation of rasayana compound as an adjuvant in the management of tuberculosis with anti-koch's treatment. | tuberculosis (tb) continues to intimidate the human race since time immemorial not only due to its effects as a medical malady, but also by its impact as a social and economic tragedy. at the dawn of the new millennium, we are still mute witnesses to the silent yet efficient march of this sagacious disease, its myriad manifestations and above all its unequalled, vicious power. through the millennia, tb never ever disappeared from the developing world. in 1991, the world health assembly (wha) res ... | 2012 | 23049182 |
| prevention of hepatotoxicity due to anti tuberculosis treatment: a novel integrative approach. | to evaluate the ability of curcuma longa (cl) and tinospora cordifolia (tc) formulation to prevent anti-tuberculosis (tb) treatment (att) induced hepatotoxicity. | 2008 | 18720535 |
| anti diabetic activity of amrithadi churnam. | amrithadi churnam - a compound ayurvedic preparation made up of tinospora cordifolia, salacia prenoides, curcuma longa, tribulus terrestris and emblica officinalis was screened for its antidiabetic activity. from the studies it could be established that amrithadi churnam at a dose level of 100mg/kg b.w. was the optimum dose in alloxan diabetic rats. no toxic effects were observed as evidenced by the study of liver enzymes and blood haematoerit. an extra pancreatic role of the drug cannot be rull ... | 1992 | 22556603 |
| effects of withania somnifera and tinospora cordifolia extracts on the side population phenotype of human epithelial cancer cells: toward targeting multidrug resistance in cancer. | recent reports suggest the existence of a subpopulation of stem-like cancer cells, termed as cancer stem cells (cscs), which bear functional and phenotypic resemblance with the adult, tissue-resident stem cells. side population (sp) assay based on differential efflux of hoechst 33342 has been effectively used for the isolation of cscs. the drug resistance properties of sp cells are typically due to the increased expression of abc transporters leading to drug efflux. conventionally used chemother ... | 2015 | 25549922 |
| an alpha-glucosidase inhibitor from an endophytic cladosporium sp. with potential as a biocontrol agent. | this study highlights the importance of alpha-glucosidase inhibitors as mechanisms for endophyte-mediated resistance to insect pests. one of the major benefits which endophytes confer on plants is providing resistance against insect pests. this built-in defense mechanism of the plant can be used for exploring ecofriendly strategies for pest control. in the present study, 34 endophytic fungi were isolated from tinospora cordifolia and screened for their ability to produce alpha-glucosidase inhibi ... | 2015 | 25432333 |