| f-coliphages, porcine adenovirus and porcine teschovirus as potential indicator viruses of fecal contamination for pork carcass processing. | there are concerns about the zoonotic transmission of viruses through undercooked pork products. there is a lack of information on suitable indicator viruses for fecal contamination with pathogenic enteric viruses in the meat processing chain. the study compared the incidence and levels of contamination of hog carcasses with f-coliphages, porcine teschovirus (ptv), and porcine adenovirus (padv) at different stages of the dressing process to assess their potential as indicator viruses of fecal co ... | 2017 | 27810445 |
| comparison of zetaplus 60s and nitrocellulose membrane filters for the simultaneous concentration of f-rna coliphages, porcine teschovirus and porcine adenovirus from river water. | increasing attention is being paid to the impact of agricultural activities on water quality to understand the impact on public health. f-rna coliphages have been proposed as viral indicators of fecal contamination while porcine teschovirus (ptv) and porcine adenovirus (padv) are proposed indicators of fecal contamination of swine origin. viruses and coliphages are present in water in very low concentrations and must be concentrated to permit their detection. there is little information comparin ... | 2014 | 24880068 |
| incorporation of porcine adenovirus 4 fiber protein enhances infectivity of adenovirus vector on dendritic cells: implications for immune-mediated cancer therapy. | one strategy in cancer immunotherapy is to capitalize on the key immunoregulatory and antigen presenting capabilities of dendritic cells (dcs). this approach is dependent on efficient delivery of tumor specific antigens to dcs, which subsequently induce an anti-tumor t-cell mediated immune response. human adenovirus serotype 5 (hadv5) has been used in human studies for gene delivery, but has limited infection in dcs, which lack the proper receptors. addition of the porcine fiber knob (pk) from p ... | 2015 | 25933160 |
| an adenovirus vector incorporating carbohydrate binding domains utilizes glycans for gene transfer. | vectors based on human adenovirus serotype 5 (hadv-5) continue to show promise as delivery vehicles for cancer gene therapy. nevertheless, it has become clear that therapeutic benefit is directly linked to tumor-specific vector localization, highlighting the need for tumor-targeted gene delivery. aberrant glycosylation of cell surface glycoproteins and glycolipids is a central feature of malignant transformation, and tumor-associated glycoforms are recognized as cancer biomarkers. on this basis, ... | 2013 | 23383334 |
| first detection of enteric adenoviruses genotype 41 in recreation spring areas of taiwan. | human adenoviruses (hadvs) are dna viruses found in recreational water, such as water parks and swimming pools. human adenovirus 41 (hadv-41) is the most common serotype detected and is a leading cause of acute diarrheal disease. the focus of this study is to determine the prevalence of hadvs in hot springs. of 57 samples collected from four different geological sites, 16 samples have shown evidence of hadvs (28.1%). hadv-41 and porcine adenovirus 5 (padv-5) were the two types isolated, with a g ... | 2017 | 28639027 |
| characterization of early region 4 of porcine adenovirus serotype 5. | to locate the e4 region on the genome of the hnf-70 prototype strain of the porcine adenovirus serotype 5 (padv-5), 4.5 kb at the extreme right end was sequenced. this area had 11 open reading frames (orfs) on the left strand encoding more than 50 amino acids (aa). a genbank homology search indicated that 8 of these orfs were unique to padv-5. orf5:253 aa, orf6:245 aa and orf11:146 aa showed similarities to known mammalian and avian adenovirus e4 orfs. the putative e4 promoter sequences were als ... | 2000 | 10949948 |
| bovine adenovirus serotype 3 utilizes sialic acid as a cellular receptor for virus entry. | bovine adenovirus serotype 3 (bad3) and porcine adenovirus serotype 3 (pad3) entry into the host cells is independent of coxsackievirus adenovirus receptor and integrins. the role of sialic acid in bad3 and pad3 entry was investigated. removal of sialic acid by neuraminidase, or blocking sialic acid by wheat germ agglutinin lectin significantly inhibited bad3, but not pad3, transduction of madin-darby bovine kidney cells. maackia amurensis agglutinin or sambucus nigra (elder) agglutinin treatmen ... | 2009 | 19646729 |
| crystallographic structure of porcine adenovirus type 4 fiber head and galectin domains. | adenovirus isolate nadc-1, a strain of porcine adenovirus type 4, has a fiber containing an n-terminal virus attachment region, shaft and head domains, and a c-terminal galectin domain connected to the head by an rgd-containing sequence. the crystal structure of the head domain is similar to previously solved adenovirus fiber head domains, but specific residues for binding the coxsackievirus and adenovirus receptor (car), cd46, or sialic acid are not conserved. the structure of the galectin doma ... | 2010 | 20686025 |