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clonorchiasis: an update.the ability of clonorchis sinensis to cause severe hepatobiliary disease is illustrated by the case we have reported, in which biliary obstruction and hepatic fibrosis resulted from the pathologic process associated with chronic clonorchiasis. immunodiagnostic tests are currently limited, and diagnosis, as illustrated by our case, relies on identification of the fluke, usually as the adult or egg stage in clinical specimens. praziquantel has revolutionized therapy of this disease, but surgical d ...19873299730
detection of serum antibody to clonorchis sinensis by enzyme-linked immunosorbent assay. 19873316481
evaluation of enzyme-linked immunosorbent assay for immunodiagnosis of clonorchiasis.two groups of patients with parasitologically proved clonorchiasis were recruited from among staff and workers of china petroleum company at miao-li county. there were 86 patients in the pre-treatment group and 143 patients in post-treatment. the latter were defined as those treated for 18 months after a daily dosage of 3 x 25 mg/kg bw/day of praziquantel. indirect elisa was performed to detect the serum antibody against clonorchis sinensis with extracted crude antigen of adult worms obtained fr ...19873322701
[case of clonorchiasis undiagnosed during life]. 19873325789
[four outbreaks of clonorchiasis sinensis in suibin farm, heilongjiang province]. 19873327666
adenocarcinoma of the pancreas associated with clonorchis sinensis infection. 19873539300
[occurrence in brazil of thiara (melanoides) tuberculata (o.f. muller, 1774) (gastropoda, prosobranchia), the 1st intermediate host of clonorchis sinensis (cobbold, 1875) (trematoda, plathyhelmintes)]. 19863554478
[some observations on the clonorchiasis intradermal test]. 19853891128
[epidemiology of clonorchiasis sinensis in guangdong province]. 19853891257
[treatment of clonorchiasis sinensis with albendazole: 50 cases]. 19853893935
structural investigation on the effects of the herbs on clonorchis sinensis in rabbits.the effects of boiled water extracts of clonorchicidal raw drugs screened by the epg counts in vivo on the structure of clonorchis sinensis were investigated. the extracts of cassia obutusifolia and dictamnus dasycarpus did not seem to induce the morphological changes of the worms, and in those of machilus thunbergii and prunús mume, widening of bladder to lower level of seminal receptacle was visible without any other changes. those of inula helenium and saussurea lappa, however, disclosed regr ...19853895883
[immune responses in rabbits infected with clonorchis sinensis].experimental rabbits were divided into single infection group, reinfection group and treatment group. both eggs per gram of feces and serum antibody were determined periodically by antiformin-ether concentration method and elisa technic, respectively. two rabbits were observed 72 weeks and 76 weeks after infection in single infection occasion. antibody elevated to the maximum during 8 and 14 weeks after infection, and then gradually decreased but still kept in detectable level till the terminati ...19853896691
intestinal parasites in southeast asian refugee children.to determine the predictability of pediatric stool-parasite patterns among various southeast asian ethnic groups, i collected data from medical and microbiology laboratory records on all southeast asian refugee children who had a stool specimen examined for ova and parasites over a 21-month period. for most of the children, the specimen was examined as part of routine "health screening." the patterns of infection by ethnic group for those vietnamese and laotian children living in seattle differ ...19853898596
[discovery of parafossarulus anomaloispiralis as the first intermediate host of clonochis sinensis]. 19853912056
treatment of clonorchis sinensis in hawaii's laotian population--experience with praziquantel. 19853980210
clonorchis sinensis infection associated with adenocarcinoma of the gallbladder and cystic duct. 19853993073
alternations of clonorchis sinensis epg by administration of herbs in rabbits.in order to investigate clonorchicidal activity in vivo, boiled water extracts of 32 species of clonorchicidal raw drugs in vitro were orally administered into rabbits infected with clonorchis sinensis. the results of the observation of epg variation were as follows: suppression effects of egg-laying capacity from the rabbits administered prunus mume and inula helenium were greatest. those from dictamnus dasycarpus and saussurea lappa were somewhat effective. machilus thunbergii and cassia obutu ...19854025216
[pathogenesis of intrahepatic cholestasis]. 19734145191
the sites of antigen formation in different developmental stages of clonorchis sinensis. 19694187952
clonorchis sinensis in a malaysian. 19684240824
liver fluke infection and infestation in southeast asia. 19724265700
the histochemistry of biliary mucins and the changes caused by infestation with clonorchis sinensis. 19704319912
drug therapy. treatment of common parasitic infections of man encountered in the united states. 2. 19724341320
intrahepatic bile duct carcinoma and c. sinensis infection in hong kong. 19734347190
[therapy of infections with clonorchis sinensis (author's transl)]. 19734355742
[human infections by fasciola hepatica]. 19724554516
comparative oncology: dogs, cats, and man. 19724557108
[the morphology of the developmental stages of the trematode clonorchis sinensis (cobbold, 1875) loose, 1907]. 19724569490
clonorchiasis studied by percutaneous cholangiography, and a therapeutic trial of toluene-2,4-diisothiocyanate. a case report. 19734580767
intestinal parasites in chinese immigrants in a canadian city. 19734586094
production and properties of reaginic antibodies in rabbits infected with clonorchis sinensis or schistosoma japonicum. 19744592582
carcinogens in the environment. 19744608383
recurrent pyogenic cholangitis in chinese immigrants. 19744609070
[clonorchis sinensis and other intestinal parasitoses in macao]. 19744618433
ultrastructural changes in the biliary tracts of guinea-pigs infected with clonorchis sinensis. 19734720911
summary of recent abstracts. ix. helminthiasis. trematode infections and cestode infections. 19714944786
[liver fluke infections: nine personal cases. ii. fluke infection by clonorchis sinensis (chinese fluke)]. 19714946441
antigens of clonorchis sinensis in experimental and human infections. 19694975976
metabolic products of adult clonorchis sinensis: their composition and antigenic potential. 19694986512
the non-antigenicity of intact ova of clonorchis sinensis. 19694996479
studies on the intradermal test with the peptide antigen obtained from clonorchis sinensis. 19705201438
maintenance of adult clonorchis sinensis in vitro. 19695373670
[biliary incidence of distomatosis due to clonorchis sinensis]. 19695376480
[efficacy of bis-dithiocarbamic acid esters against opisthorchis felineus and clonorchis sinensis]. 19705449380
clonorchis sinensis in west malaysia. 19705528459
haemoptysis and transitory lung-infiltrations associated with clonorchis sinensis. 19675588220
[clonorchis sinensis in miyagi prefecture. 2. survey of contaminated districts by domestic cats]. 19675624898
[clonorchis sinensis in miyagi prefecture. 3. relationship between snail habitats and clonorchis carriers]. 19675626720
route of entry of clonorchis sinensis to the mammalian liver. 19685673658
the in vitro action of antisera on the adults of clonorchis sinensis. 19695824280
the life cycle of clonorchis sinensis: a comment on the presentation in the seventh edition of craig and faust's clinical parasitology. 19655848830
isolation and purification of antigen from adult clonorchis sinensis for complement fixation and precipitin tests. 19655856857
[epidemiological surveys on the intermediate hosts of clonorchis sinensis in hokuriku district and yamagata prefecture]. 19655894913
[2 cases of clonorchis sinensis infection with associated infestation with other parasites]. 19665946944
acute pancreatitis due to clonorchis sinensis. 19665955117
the pathology of clonorchis sinensis infestation of the pancreas. 19676029756
[clonorchis sinensis in miyagi prefecture. 1. clonorchiasis among inhabitants]. 19676069821
liver carcinoma and liver fluke infection.the neoplastic transformation of bile duct changes induced by infections due to clonorchis sinensis or opisthorchis viverrini has been persistently debated because of the difficulty to establish the causative relation between those trematode infections and the development of primary carcinoma of the liver (pcal) which has been found in hong kong, china, korea and thailand. the following observations, however, clearly support the hypothesis that clonorchiasis and opisthorchiasis are basic etiolog ...19846095876
[comparison of pyquiton (biltricied) with hexa-chloro-p-xylol in the treatment of clonorchis sinensis infection]. 19826216006
helminths in the induction of cancer: opisthorchis viverrini, clonorchis sinensis and cholangiocarcinoma.opisthorchis and clonorchis parasitize the bile ducts of millions of persons in the far east. the most important aspect of infection with these flukes is their ability to initiate cancer. numerous studies have shown these flukes to occur in association with cholangiocarcinoma far more frequently than can be explained by chance. experimental studies in animals have confirmed the carcinogenic potential of these parasites. although the pathogenesis remains unclear, the initial carcinogenic event is ...19806252671
promotion of n-nitrosodimethylamine-initiated bile duct carcinogenesis in the hamster by the human liver fluke, opisthorchis viverrini.four groups of male golden syrian hamsters were treated as follows: group i received 50 opisthorchis viverrini metacercariae followed 41 days later by a single oral dose of 1.6 mg n-nitrosodimethylamine (ndma). group ii received a single oral dose of 1.6 mg ndma followed 96 h later by 50 o. viverrini metacercariae, group iii received a single oral dose of 1.6 mg ndma only and group iv 50 o. viverrini metacercariae only. mortality was highest in group i and ii animals receiving both ndma and para ...19836307539
pathology and immunology of clonorchis sinensis infection of the liver.the existence of clonorchiasis cases among the asian immigrants and the major clinical and pathologic features encountered in those patients is emphasized. owing to the longevity of the parasite, clinical symptoms may occur long after endemic exposure. the common manifestations among the immigrants are recurrent pyogenic cholangitis and pancreatitis. the relationship between clonorchiasis and cholangiocarcinoma and the possible pathogenesis of this tumor are discussed. the specific immunologic p ...19846329070
ultrastructural investigations on the effects of praziquantel on human trematodes from asia: clonorchis sinensis, metagonimus yokogawai, opisthorchis viverrini, paragonimus westermani and schistosoma japonicum.the effect of praziquantel (biltricide) on the ultrastructure of trematodes pathogenic to man in asia was investigated in: clonorchis sinensis, opisthorchis viverrini, schistosoma japonicum, metagonimus yokogawai, and paragonimus westermani. the different parasites were isolated from their respective experimental hosts and uniformly incubated for 5, 15, 30 or 60 min at 37 degrees c in medium tc 199 containing 0, 1, 10 or 100 micrograms praziquantel/ml. all parasites exposed to praziquantel were ...19836338885
praziquantel. 19836344048
sensitivity of passive cutaneous anaphylaxis in rats. i. inverse relationship between pca sensitivity and amount of ige present on mast cells.passive cutaneous anaphylaxis (pca) sensitivity and ige antibody production were examined in rats from four different outbred colonies: wistar a, wistar b, sprague-dawley, and donryu. pca sensitivity was the highest in wistar b and the lowest in wistar a rats using anti-ascaris, antibovine serum albumin, and anti-clonorchis sinensis ige antibodies. the pca sensitivity related inversely to the reverse pca reaction with rabbit antirat ige antibody, suggesting that preexisting ige molecules on the ...19836347905
[operculated eggs of platyhelminths: description of atypias and attempted explanation of their genesis].the authors remind the formation of operculated eggs. atypical eggs of clonorchis sinensis, fasciola hepatica and diphyllobothrium latum are described: no operculum for the two first species and existence of non-described buttons for the two last species. these anomalies could be explained by the way of formation of these eggs.19836357030
[scanning electron microscopy of clonorchis sinensis]. 19836380798
a clinical study of laotian refugees infected with clonorchis sinensis or opisthorchis viverrini.twenty-six laotian refugees infected with clonorchis or opisthorchis liver flukes, and 15 uninfected controls, were assessed clinically by history, physical examination, serum 5'nucleotidase level, and serum immunoglobulin e level. ultrasound studies of the biliary tract were also done on a subset of six infected subjects. the results showed no differences between subjects and controls with respect to clinical symptoms, physical findings, 5'nucleotidase, or biliary ultrasound. mean serum ige lev ...19846391229
therapy of fluke infections in the past. a review.chemotherapy of trematode infections has been studied intensively in the past. the compounds so far used for the treatment of those parasitic infections were not satisfactory, however, because of their poor tolerability and/or their limited anthelmintic efficacy. since the introduction of tartar emetic in 1918, a number of antimonial as well as non-antimonial preparations have been used for the treatment of schistosomiasis. in the treatment of clonorchiasis with antimony preparations, gentian vi ...19846391498
parasitological examinations and immunodiagnostic advances in fluke infections.a reliable diagnosis of fluke infections should be based on the demonstration of parasite eggs in either faeces, duodenal liquid or sputum, depending on the type of infection. such an examination permits the identification of the species, and counting eggs establishes the intensity of infection. unfortunately this examination is useful only when intensity is rather high. the diagnosis of slight infections is uncertain and can vary considerably from one sample to another. in this area of parasito ...19846391499
clonorchis sinensis: life cycle, intermediate hosts, transmission to man and geographical distribution in korea.the snail host of clonorchis sinensis in korea is referred to as parafossarulus manchouricus, but it has been recorded also as bulimus striatulus japonicus in literature published up to late 1950. the specific name of the snail was corrected such that bulimus striatulus of china, japan, and korea should be incorporated in the species of p. manchouricus. in general, the snail exists in limited areas of the rivers han, kum, mankyung, naktong, and yeongsan, and the infestation of the snail with the ...19846391501
clonorchis sinensis: pathogenesis and clinical features of infection.when larvae of c. sinensis reach the biliary system and mature, the flukes provoke pathological changes, both as a result of local trauma and of toxic irritation. the appearances vary with duration and severity of the infestation, but they are sufficiently distinctive and characteristic to allow a classification into four phases as follows; 1st phase, desquamation of epithelial cells, 2nd phase, hyperplasia and desquamation of epithelial cells, 3rd phase, hyperplasia and desquamation of epitheli ...19846391502
clonorchis sinensis: experimental and clinical studies with praziquantel in korea.experimental studies: a high degree of prophylactic effect was achieved with a single dose of praziquantel (2-cyclohexylcarbonyl-1,2,3,6,7,11b-hexahydro-4h-pyrazino [2,1-a]isoquinolin-4-one, embay 8440, biltricide), 600 mg/kg bwt once a day, when given to rats at least one day before the infection. to treat the larvae or immature worms at early stages of infection, the following regimens were recommended: 2 x 50 mg/kg bwt for 5 days (soh et al. 1980) or 3 x 100 mg/kg bwt for 2 days. by morpholog ...19846391503
clonorchis sinensis: epidemiology in taiwan and clinical experience with praziquantel.the human infection rate of clonorchiasis in taiwan was estimated with 0.012-1.5%. three endemic areas were noted, e.g. mei-nung in the south (52%), sunmoon lake area in the centre (52%), and miao-li in the middle (57%) of taiwan. those are areas where local people customarily eat raw fresh-water fish. from december 1979 to december 1981, a new trematodicide, praziquantel (2-cyclohexylcarbonyl-1,2,3,6,7,11b-hexahydro-4h-pyrazino[2,1-a]++ +isoquinolin-4-one, embay 8440, biltricide), was evaluated ...19846391504
[amino acid composition of antigens of schistosoma japonicum eggs and the adult schistosoma japonicum, paragonimus westermani and clonorchis sinensis]. 19846391728
[ultrastructural study on the tegument, epithelial cells and muscles of clonorchis sinensis treated with pyquiton]. 19846391729
[long-term observation of circulating antigen in sera from patients with clonorchiasis using the enzyme-linked immunosorbent assay (double sandwich method)]. 19846398212
[changes in antibody levels in patients after treatment of clonorchis sinensis infection]. 19836413024
remarks on the diagnosis of clonorchis sinensis infection.a number of techniques have been developed for the diagnosis of clonorchis sinensis infection. although the most reliable technique for this infection are the various stool examinations in the laboratory, practical problems such as difficulties of stool collection and mass examinations need more applicable methods for epidemiological studies. during past decades some serologic and immunologic methods such as intradermal skin test, gel-diffusion technique, complement fixation test, haemagglutinat ...19846439228
[diffusion in gel-enzyme linked immunosorbent assay in the diagnosis of clonorchiasis sinensis]. 19846441693
cholangiographic appearance in clonorchiasis.clonorchiasis may lead to cholangitis. clonorchis sinensis infiltration of the biliary system produces an easily recognisable cholangiographic picture. the findings consist of characteristic filling defects and changes in the intrahepatic and extrahepatic ducts. the filling defects are usually small and irregular and the size is uniform. the change in the intrahepatic ducts consists of ductal dilatation involving especially the smaller ducts, apparent elongation, tortuosity and duct wall irregul ...19846466940
endoscopic biliary lavage in a case of clonorchis sinensis. 19846489711
severe acute pancreatitis caused by parasites in the common bile duct.nine cases of acute pancreatitis due to parasites in the common bile duct (ascaris lumbricoides 4, clonorchis sinensis 5) are reported. eight cases were discovered at laparotomy and one at postmortem. the indications for operation were worsening pancreatitis, sepsis or cholangitis. decompression of the biliary system and removal of parasites resulted in the recovery of the eight cases operated upon. in endemic areas, all patients with acute pancreatitis should be screened for parasites. antibiot ...19846530710
[immunodiagnosis of human clonorchiasis by a micro-enzyme-linked immunosorbent assay].a micro-enzyme-linked immunosorbent assay (elisa) utilizing antigen from lyophilized clonorchis sinensis adult worms extracted with triethanolamine buffered saline (tbs), veronal buffered saline (vbs) or phosphate buffered saline (pbs) were used to test 66, 31 and 9 sera from clonorchiasis patients, uninfected normal humen and patients with other parasitic infections, respectively. four different combinations of incubation time between serum with antigen and serum with conjugate at either 37 deg ...19846532654
clonorchiasis: treatment with praziquantel in 50 cases.of 50 patients infected with clonorchis sinensis, 3 groups were formed and treated with different doses of praziquantel (2-cyclohexylcarbonyl-1,2,3,6,7,11b-hexahydro-4h-pyrazino[2,1-a] isoquinolin- 4-one). 24 patients out of 50 were followed up for 3 months and another 10 for 6 months. it is evident that this single-day treatment is effective and satisfactory. in 5 patients with glucose-6-phosphate dehydrogenase deficiency no haemolysis occurred.19846542382
changing patterns of some trematode infections in asia.in certain areas of asia the pattern of trematode infections in both man and animals seems to have changed in the recent past. on taiwan, for example, paragonimiasis, fasciolopsiasis and schistosomiasis were at one time highly endemic in certain locations, but in recent years these parasitoses have been difficult to find in definitive, intermediate as well as reservoir hosts. education, industrialization, alterations in the ecology and the use of modern agricultural practices have contributed to ...19846542400
large scale treatment of clonorchis sinensis infections with praziquantel under field conditions.a study on mass treatment of clonorchis sinensis infections with praziquantel (2-cyclohexylcarbonyl-1,2,3,6,7,11b-hexahydro-4h-pyrazino[2,1-a] isoquinolin-4-one, embay 8440, biltricide) was performed in order to find out the most effective and convenient administration scheme of this drug. 3543 (12.3%) out of 28 826 examined individuals were found to be infected with c. sinensis. first, the cellophane thick smear technique was used. then the infected people were reexamined for determination of e ...19846542401
[immunodiagnosis of rabbit clonorchiasis by enzyme-linked immunosorbent assay].enzyme-linked immunosorbent assay (elisa) was successfully applied to the immunodiagnosis of parasitic disease in 1974 by engvall and perlmann. in our study, this technic was used to test rabbits infected with chonorchis sinensis metacercariae experimentally. the optimal conditions for the test were determined and summarized as follows: 1. the optimal concentration of vbs antigen was 4 micrograms/ml, showing the highest o.d. in the detection of elisa test. 2. four hundred-fold diluted alkaline p ...19836617314
[prevalence of protozoans helminths among cats purchased for experimental use in the kanto area].prevalence of protozoan and helminth parasites in adult cats for experimental use obtained from kanto area, japan during the period of 1973-74 (91 cats) and 1980-81 (80 cats) was investigated by means of autopsy, fecal examination and serological tests. no protozoa were found in blood smear specimens. the rate of positive toxoplasma antibody tests was 65.4% (hemagglutination test) in 1973-74 and 26.3% (latex agglutination test) in 1980-81. oocysts of coccidia found in feces were isospora felis a ...19836653679
clinical investigation of praziquantel in the treatment of clonorchiasis sinensis. 19826761408
parasitological investigation on the ancient corpse of the western han dynasty unearthed from tomb no. 168 on phoenix hill in jiangling county. 19816762510
screening of the wormicidal chinese raw drugs on clonorchis sinensis.the wormicidal effect on clonorchis sinensis in boiled water extracts of 223 species (vegetable origin 206, animal origin 10, mineral origin 7) of raw drugs prescribed in oriental medicine was observed in vitro. the wormicidal substances were detected from 31 of the above-mentioned species. the wormicidal substances extracted from platycodon grandiflorum (radix), schizandra chinensis (fruit), polygala tenuifolia (herb) and aster tataricus (radix) were most effective. those from smilax glabra (ra ...19816764091
[survey on clonorchis sinensis infection in 22 counties and municipalities of guangdong province]. 19826764380
[cercarial chaetotaxy of a korean strain of clonorchis sinensis. probable presence of this trematode in africa].the authors show a close morphological and chaetotaxical similarity between two strains of cercariae from naturally infested snails; the first strain, determinated as clonorchis sinensis comes from asia; the second one comes from africa and its presence in this continent suggests that clonorchis has been introduced there.19826764866
experience in the treatment of clonorchiasis by professor deng tietao. 19826765850
comparison of praziquantel, amoscanate and hexachloroparaxylol in clonorchiasis sinensis. 19806780274
hybridoma-derived antibody with immunodiagnostic potential for schistosomiasis japonica.a murine hybridoma-derived antibody (iph.134) has been produced which has apparent high binding specificity for an extract of schistosoma japonicum adult worms. no binding was detected to extracts of s. japonicum eggs or to extracts from other adult trematodes (fasciola hepatica, paragonimus westermanii, clonorchis sinensis, and schistosoma mansoni) and several other helminths and protozoa. when sera from two series of s. japonicum-infected philippine patients (19 and 20 patients, respectively) ...19816789330
[ultrastructure of rabbit biliary tract infected with clonorchis sinensis (author's transl)]. 19816947060
common bile duct obstruction and cholangiohepatitis in clonorchiasis.this report describes a patient with common bile duct obstruction and cholangiohepatitis. patients with clonorchiasis are usually asymptomatic and treatment is limited to complications. treatment consists of cholecystectomy, choledochotomy, and t-tube drainage. a bypass procedure is indicated in cases of heavy infestation and recurrent disease.19806990027
clonorchiasis: a report of four cases and discussion of unusual manifestations.clonorchiasis is still a problem for asian immigrants to north america, and is occasionally seen among american residents who contract the disease during long-term or short-term visits to endemic areas. the incidence of clonorchiasis is especially high among chinese immigrants from hong kong. the acute symptoms most frequently encountered in this group of patients are those of recurrent pyogenic cholangitis and acute pancreatitis. two american cases are reported together with a brief discussion ...19807004219
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