| identification and molecular discrimination of toxigenic and nontoxigenic diphtheria corynebacterium strains by combined real-time polymerase chain reaction assays. | with the recognition of several diphtheria outbreaks and the emergence of nontoxigenic corynebacteria strains, there has been renewed interest in the development of laboratory diagnostic methods. previously reported polymerase chain reaction (pcr) assays can have low diagnostic sensitivity or give species misidentifications among clinical isolates. the aim of the present study was the development of combined real-time pcr assays, based on the tox and rpob genes, for the detection and differentia ... | 2012 | 22494559 |
| analysis of toxigenic corynebacterium ulcerans strains revealing potential for false-negative real-time pcr results. | diphtheria surveillance depends on the rapid and reliable recognition of the toxin gene in corynebacterium diphtheriae. real-time pcr is a rapid tool to confirm the presence of the diphtheria toxin gene (tox) in an isolate or specimen. we report that some toxigenic corynebacterium ulcerans strains show atypical results in a real-time pcr for tox. | 2008 | 17989189 |
| detection of toxigenic corynebacterium diphtheriae and corynebacterium ulcerans strains by a novel real-time pcr. | | 2008 | 18550743 |
| first detection of corynebacterium ulcerans producing a diphtheria-like toxin in a case of human with pulmonary infection in the rio de janeiro metropolitan area, brazil. | the frequency and severity of human infections associated with corynebacterium ulcerans appear to be increasing in different countries. here, we describe the first c. ulcerans strain producing a diphtheria-like toxin isolated from an elderly woman with a fatal pulmonary infection and a history of leg skin ulcers in the rio de janeiro metropolitan area. | 2008 | 18660996 |
| multidisciplinary approach to the management of a case of classical respiratory diphtheria requiring percutaneous endoscopic gastrostomy feeding. | we present a case of a caucasian woman aged 67 years referred with a 4-day history of sore throat, dysphagia, fever and nasal blockage. examination revealed a swollen neck and pharyngeal pseudomembrane. a throat swab was positive on culture for corynebacterium ulcerans, with toxin expression confirmed on pcr and elek testing. a diagnosis of classical respiratory diphtheria was made, with subsequent confirmation of the patient's domesticated dog as the source of infection. the dog had recently be ... | 2017 | 28264806 |
| diphtheria: a zoonotic disease in france? | thanks to vaccination, diphtheria has almost disappeared in france. the case definition, used for mandatory notification, was expanded in 2003 to include toxin-producing strains of corynebacterium ulcerans. we describe the epidemiology of diphtheria in france from 1990 to 2008. no cases occurred between 1990 and 2001. since 2002, 19 cases have been reported: 4 cases due to corynebacterium diphtheriae related to exposure in endemic countries, and 15 cases due to other corynebacteria, including 4 ... | 2009 | 19393707 |
| diphtheria in the united kingdom, 1986-2008: the increasing role of corynebacterium ulcerans. | diphtheria is an uncommon disease in the uk due to an effective immunization programme; consequently when cases do arise, there can be delays in diagnosis and case-fatality rates remain high. we reviewed 102 patients with infections caused by toxigenic corynebacteria (an average of four per year) reported in the uk between 1986 and 2008: 42 corynebacterium diphtheriae, 59 c. ulcerans and one c. pseudotuberculosis, as well as 23 asymptomatic carriers. five fatalities were reported, all in unvacci ... | 2010 | 20696088 |
| Diphtheria-like Illness due to Corynebacterium Ulcerans infection. | | 2011 | 22028605 |
| a bioactive flavonoid from pavetta crassipes k. schum. | in our continued search for bioactive compounds from plants, conscious effort is being made to rapidly analyze ethnobotanical plants used for treating various ailments by traditional healers before this information is irrevocably lost as societies advance and rural communities become urbanized. | 2011 | 22373191 |
| nontoxigenic tox-bearing corynebacterium ulcerans infection among game animals, germany. | corynebacterium ulcerans may cause diphtheria in humans and caseous lymphadenitis in animals. we isolated nontoxigenic tox-bearing c. ulcerans from 13 game animals in germany. our results indicate a role for game animals as reservoirs for zoonotic c. ulcerans. | 0 | 24572455 |
| toxigenic corynebacterium ulcerans isolated from a wild bird (ural owl) and its feed (shrew-moles): comparison of molecular types with human isolates. | corynebacterium ulcerans is a pathogen causing diphtheria-like illness to humans. in contrast to diphtheria by corynebacterium diphtheriae circulating mostly among humans, c. ulcerans infection is zoonotic. the present study aimed to clarify how a zoonotic pathogen c. ulcerans circulates among wild birds and animals. | 2016 | 27000873 |
| evaluation of invertebrate infection models for pathogenic corynebacteria. | for several pathogenic bacteria, model systems for host-pathogen interactions were developed, which provide the possibility of quick and cost-effective high throughput screening of mutant bacteria for genes involved in pathogenesis. a number of different model systems, including amoeba, nematodes, insects, and fish, have been introduced, and it was observed that different bacteria respond in different ways to putative surrogate hosts, and distinct model systems might be more or less suitable for ... | 2012 | 22443092 |
| development, validation and implementation of a quadruplex real-time pcr assay for identification of potentially toxigenic corynebacteria. | toxigenic corynebacteria are uncommon in the uk; however, laboratory confirmation by the national reference laboratory can inform public health action according to national guidelines. standard phenotypic tests for identification and toxin expression of isolates can take from ≥24 to ≥48 h from receipt. to decrease the time to result, a real-time pcr (qpcr) assay was developed for confirmation of both identification of corynebacterium diphtheriae and corynebacterium ulcerans/corynebacterium pseud ... | 2016 | 27902437 |
| immunological characterization of diphtheria toxin recovered from corynebacterium pseudotuberculosis. | diphtheria toxin (dt) is a potent toxin produced by the so-called diphtheria group which includes corynebacterium diphtheriae (c. diphtheriae), corynebacterium ulcerans (c. ulcerans), and corynebacterium pseudotuberculosis (c. pseudotuberculosis). the present investigation is aimed to study in detail the production of dt by c. pseudotuberculosis. twenty isolates were obtained from sheep diseased with caseous lymphadenitis (cla) and twenty-six isolates were obtained from 26 buffaloes diseased wit ... | 2016 | 26981011 |
| a novel experimental platform for toxigenic and non-toxigenic corynebacterium ulcerans infection in mice. | corynebacterium ulcerans is a zoonotic pathogen that can produce diphtheria toxin and causes an illness categorized as diphtheria in the european union because its clinical appearance is similar to that of diphtheria caused by corynebacterium diphtheriae. despite the importance of the pathogen in public health, the organism's mechanism of infection has not been extensively studied, especially in experimental animal models. therefore in the present study we constructed an intranasal infection sys ... | 2016 | 26607400 |
| opposite nucleotide usage biases in different parts of the corynebacterium diphtheriae spac gene. | in this work we described a bacterial open reading frame with two different directions of nucleotide usage biases in its two parts. the level of gc-content in third codon positions (3gc) is equal to 40.17 ± 0.22% during the most of the length of corynebacterium diphtheriae spac gene. however, in the 3'-end of the same gene (from codon #1600 to codon #1873) 3gc level is equal to 64.61 ± 0.91%. using original methodology ('vvtak sliding window' and 'vvtak varinvar') we approved that there is an on ... | 2015 | 26561319 |
| caenorhabditis elegans star formation and negative chemotaxis induced by infection with corynebacteria. | caenorhabditis elegans is one of the major model systems in biology based on advantageous properties such as short life span, transparency, genetic tractability and ease of culture using an escherichia coli diet. in its natural habitat, compost and rotting plant material, this nematode lives on bacteria. however, c. elegans is a predator of bacteria, but can also be infected by nematopathogenic coryneform bacteria such microbacterium and leucobacter species, which display intriguing and diverse ... | 2016 | 26490043 |
| cutaneous ulcers in a returning traveller: a rare case of imported diphtheria in the uk. | we describe a case of cutaneous diphtheria in the uk, presenting as lower leg ulcers in a returning traveller, and discuss the epidemiology, significance and public health implications of this disease and the therapeutic options available. a 65-year-old woman presented with a 6-week history of multiple ulcers appearing on her legs following a holiday in kenya. culture of biopsy tissue grew corynebacterium diphtheriae. a cascade of therapeutic and public health interventions followed, many of whi ... | 2016 | 26455435 |
| molecular and epidemiological review of toxigenic diphtheria infections in england between 2007 and 2013. | human infections caused by toxigenic corynebacteria occur sporadically across europe. in this report, we undertook the epidemiological and molecular characterization of all toxigenic corynebacterium strains isolated in england between january 2007 and december 2013. epidemiological aspects include case demographics, risk factors, clinical presentation, treatment, and outcome. molecular characterization was performed using multilocus sequence typing (mlst) alongside traditional phenotypic methods ... | 2015 | 25502525 |
| toxigenic corynebacterium ulcerans in human and non-toxigenic corynebacterium diphtheriae in cat. | corynebacterium diphtheriae and corynebacterium ulcerans are rarely isolated from clinical samples in belgium. a case of toxigenic c. ulcerans in a woman is described, which confirms that this pathogen is still present. during investigation of the patient's cats, only a non-toxigenic toxin-bearing c. diphtheriae strain was detected. | 2013 | 25356320 |
| multilocus sequence typing of corynebacterium ulcerans provides evidence for zoonotic transmission and for increased prevalence of certain sequence types among toxigenic strains. | human-to-human-transmitted corynebacterium diphtheriae was historically the main pathogen causing diphtheria and has therefore been studied extensively in the past. more recently, diphtheria caused by toxigenic corynebacterium ulcerans is an emerging disease in several industrial countries, including the united kingdom, the united states, france, and germany. however, toxigenic c. ulcerans has so far been almost neglected in the development of epidemiologic tools. one of the most important tools ... | 2014 | 25320226 |
| multiplex polymerase chain reaction to identify and determine the toxigenicity of corynebacterium spp with zoonotic potential and an overview of human and animal infections. | corynebacterium diphtheriae, corynebacterium ulcerans and corynebacterium pseudotuberculosis constitute a group of potentially toxigenic microorganisms that are related to different infectious processes in animal and human hosts. currently, there is a lack of information on the prevalence of disease caused by these pathogens, which is partially due to a reduction in the frequency of routine laboratory testing. in this study, a multiplex polymerase chain reaction (mpcr) assay that can simultaneou ... | 2013 | 23778659 |
| diphtheria in europe: current problems and new challenges. | diphtheria, caused by toxigenic strains of corynebacterium diphtheriae, is an ancient disease with high incidence and mortality that has always been characterized by epidemic waves of occurrence. whilst towards the beginning of the 1980s, many european countries were progressing towards the elimination of diphtheria, an epidemic re-emergence of diphtheria in the russian federation and the newly independent states of the former soviet union demonstrated a continuous threat of the disease into the ... | 2012 | 22568715 |
| notes from the field: respiratory diphtheria-like illness caused by toxigenic corynebacterium ulcerans --- idaho, 2010. | on september 12, 2010, the idaho department of health and welfare was notified of a case of respiratory diphtheria-like illness in an idaho man aged 80 years whose pharyngeal specimens yielded corynebacterium ulcerans. although c. ulcerans is zoonotic, the patient reported no animal contact or consumption of an unpasteurized dairy product. his vaccination history was unknown. respiratory diphtheria-like illness from c. ulcerans is uncommon but has been reported in industrialized countries where ... | 2011 | 21270746 |
| rapid detection and molecular differentiation of toxigenic corynebacterium diphtheriae and corynebacterium ulcerans strains by lightcycler pcr. | the systemic symptoms of diphtheria are caused by the tox-encoded diphtheria toxin (dt) which is produced by toxigenic corynebacterium spp. besides the classical agent c. diphtheriae, the zoonotic pathogen c. ulcerans has increasingly been reported as an emerging pathogen for diphtheria. the reliable detection of toxigenic corynebacterium spp. is substantial for both diphtheria surveillance in the public health sector and the clinical work-up of a patient with diphtheria-like symptoms. since the ... | 2011 | 21593261 |
| corynebacterium ulcerans from diseased wild boars. | two corynebacterium strains were isolated from lymph nodes of wild boars showing severe alterations caused by caseous lymphadenitis. the wild boars came from different districts in southern germany; one was found dead, the other had been shot. the two corynebacterium strains obtained were both positive for phospholipase d. further analysis of biochemical profiles did not allow unambiguous differentiation between corynebacterium ulcerans and corynebacterium pseudotuberculosis. fourier-transformed ... | 2011 | 21824349 |
| draft genome sequence of corynebacterium ulcerans strain 04-3911, isolated from humans. | corynebacterium ulceransis a pathogenic bacterium infecting wild and domesticated animals; some infection cases in humans have increased throughout the world. the current study describes the draft genome of strain 04-3911, isolated from humans. the draft genome has 2,492,680 bp, 2,143 coding sequences, 12 rrna genes, and 50 trna genes. | 2016 | 27034486 |
| [corynebacterium ulcerans pulmonary infection]. | corynebacterium ulcerans is a bacterium able to infect humans by inducing a disease close to diphtheria. we describe the case of a 83-year-old patient hospitalized as a matter of urgency in intensive care for which c. ulcerans was isolated in pure culture in its bronchial samples. even if the isolate was not secreting toxin in vitro, it possesses the tox gene which motivated the use of specific antitoxin serum. after two months of intensive care the patient went out of the service. it is about a ... | 2016 | 26878616 |
| draft genome sequence of corynebacterium ulcerans frc58, isolated from the bronchitic aspiration of a patient in france. | corynebacterium ulcerans is a bacterial species with high importance because it causes infections in animals and, rarely, in humans. its virulence mechanisms remain unclear. the current study describes the draft genome of c. ulcerans frc58, which was isolated from the bronchitic aspiration of a patient in france. | 2014 | 24407640 |
| corynebacterium ulcerans in ferrets. | | 2014 | 24377676 |
| corynebacterium ulcerans isolates from humans and dogs: fibrinogen, fibronectin and collagen-binding, antimicrobial and pfge profiles. | corynebacterium ulcerans has been increasingly isolated as an emerging zoonotic agent of diphtheria and other infections from companion animals. since pets are able to act as symptomless carriers, it is also essential to identify virulence potential for humans of these isolates. in this work the ability of c. ulcerans to bind to fibrinogen (fbg), fibronectin (fn) and type i collagen as well the genetic relationship among strains isolated from human and asymptomatic dogs in rio de janeiro (brazil ... | 2014 | 24281735 |
| a case report and epidemiological investigation of axillary lymph node abscess caused by corynebacterium ulcerans in an hiv-1-positive patient. | a human immunodeficiency virus-1 (hiv-1)-positive male undergoing antiretroviral therapy was diagnosed with an axillary lymph node abscess caused by corynebacterium ulcerans, and an environmental survey revealed that the patient's cat as the source of infection. | 2014 | 24054497 |
| isolation and characterization of toxigenic corynebacterium ulcerans from 2 closed colonies of cynomolgus macaques (macaca fascicularis) in japan. | the aim of the present study was to determine the prevalence of infection by toxigenic corynebacterium ulcerans in cynomolgus macaques (macaca fascicularis) housed in an animal facility in japan. samples from the pharynges of animals from 2 closed colonies (colony a, n = 47; colony b, n = 21) were cultured. c. ulcerans grew from 43% and 47% of the samples from colonies a and b, respectively. the toxigenicity of these isolates was assessed by using pcr analysis for the diphtheria toxin gene and t ... | 2013 | 23759530 |
| toxigenic corynebacterium ulcerans isolated from a hunting dog and its diphtheria toxin antibody titer. | toxigenic corynebacterium ulcerans is a zoonotic pathogen that produces diphtheria toxin and causes a diphtheria-like illness in humans. the organism is known to infect and circulate among dogs, which can then transmit it to humans. furthermore, previous studies have found that c. ulcerans is carried by wild animals, including game animals. in the present study, we tested hunting and companion dogs for the presence of toxigenic c. ulcerans and succeeded in isolating the bacterium from a hunting ... | 2016 | 26853714 |
| the killing of macrophages by corynebacterium ulcerans. | corynebacterium ulcerans is an emerging pathogen transmitted by a zoonotic pathway with a very broad host spectrum to humans. despite rising numbers of infections and potentially fatal outcomes, data on the molecular basis of pathogenicity are scarce. in this study, the interaction of 2 c. ulcerans isolates - one from an asymptomatic dog, one from a fatal case of human infection - with human macrophages was investigated. c. ulcerans strains were able to survive in macrophages for at least 20 hou ... | 2016 | 26632348 |
| non-toxigenic tox gene-bearing corynebacterium ulcerans in a traumatic ulcer from a human case and his asymptomatic dog. | a non-toxigenic tox gene-bearing (nttb) corynebacterium ulcerans was grown from the wound of a 61-year-old gardener and in a nasal specimen from the patient's asymptomatic dog. the two isolates were similar in terms of antibiogram, multilocus sequence typing (st341), virulence genes, and only three snps were found to differentiate the two nttb c. ulcerans isolates supporting a zoonotic transmission to or between the patient and his dog. of interest, we found that the two c. ulcerans isolates, al ... | 2015 | 26284490 |
| corynebacterium pelargi sp. nov., isolated from the trachea of white stork nestlings. | a gram-stain-positive, pleomorphic, oxidase-negative, non-motile isolate from the trachea of a white stork from poland, designated strain 136/3(t), was subjected to a comprehensive taxonomic investigation. a comparative analysis of the 16s rrna gene sequence showed highest similarities to corynebacterium mustelae , corynebacterium pseudotuberculosis , corynebacterium vitaeruminis and corynebacterium ulcerans (96.0-96.3%). the quinone system consisted of major amounts of mk-8(h2), minor amounts o ... | 2015 | 25678678 |
| characterization of corynebacterium species in macaques. | bacteria of the genus corynebacterium are important primary and opportunistic pathogens. many are zoonotic agents. in this report, phenotypic (api coryne analysis), genetic (rpob and 16s rrna gene sequencing), and physical methods (ms) were used to distinguish the closely related diphtheroid species corynebacterium ulcerans and corynebacterium pseudotuberculosis, and to definitively diagnose corynebacterium renale from cephalic implants of rhesus (macaca mulatta) and cynomolgus (macaca fascicula ... | 2012 | 22723254 |
| corynebacterium ulcerans 0102 carries the gene encoding diphtheria toxin on a prophage different from the c. diphtheriae nctc 13129 prophage. | corynebacterium ulcerans can cause a diphtheria-like illness, especially when the bacterium is lysogenized with a tox gene-carrying bacteriophage that produces diphtheria toxin. acquisition of toxigenicity upon phage lysogenization is a common feature of c. ulcerans and c. diphtheriae. however, because of a lack of c. ulcerans genome information, a detailed comparison of prophages has not been possible between these two clinically important and closely related bacterial species. | 2012 | 22583953 |
| corynebacterium ulcerans, an emerging human pathogen. | while formerly known infections of corynebacterium ulcerans are rare and mainly associated with contact to infected cattle, c. ulcerans has become an emerging pathogen today. in western europe, cases of respiratory diphtheria caused by c. ulcerans have been reported more often than infections by corynebacterium diphtheria, while systemic infections are also increasingly reported. little is known about factors that contribute to host colonization and virulence of this zoonotic pathogen. research ... | 2016 | 27545005 |
| draft genome sequence of toxigenic corynebacterium ulcerans strain 03-8664 isolated from a human throat. | corynebacterium ulcerans is an emergent pathogen infecting wild and domesticated animals worldwide that may serve as reservoirs for zoonotic infections. in this study, we present the draft genome of c. ulcerans strain 03-8664. the draft genome has 2,428,683 bp, 2,262 coding sequences, and 12 rrna genes. | 2016 | 27469956 |
| draft genome sequence of toxigenic corynebacterium ulcerans strain 04-7514, isolated from a dog in france. | here, we present the draft genome of toxigeniccorynebacterium ulceransstrain 04-7514. the draft genome has 2,497,845 bp, 2,059 coding sequences, 12 rrna genes, 46 trna genes, 150 pseudogenes, 1 clustered regularly interspaced short palindromic repeat (crispr) array, and a g+c content of 53.50%. | 2016 | 27034487 |
| eosinophilic granuloma with splendore-hoeppli material caused by toxigenic corynebacterium ulcerans in a heifer. | raised lesions were present on the left nasal vestibule of a 20-month-old japanese brown heifer. the largest mass which caused partial nasal obstruction was removed surgically. corynebacterium ulcerans was identified in the mass. 16s ribosomal rna and rna polymerase beta subunit genes were 100% and 98% identical to other c. ulcerans strains. histologically, multiple foci of eosinophilic granuloma with splendore-hoeppli material were seen. rod-shaped gram-positive organisms were detected with met ... | 2014 | 24632861 |
| maprepeat: an approach for effective assembly of repetitive regions in prokaryotic genomes. | the newest technologies for dna sequencing have led to the determination of the primary structure of the genomes of organisms, mainly prokaryotes, with high efficiency and at lower costs. however, the presence of regions with repetitive sequences, in addition to the short reads produced by the next-generation sequencing (ngs) platforms, created a lot of difficulty in reconstructing the original genome in silico. thus, even today, genome assembly continues to be one of the major challenges in bio ... | 2015 | 26229287 |
| corynebacterium ulcerans cutaneous diphtheria. | we describe the case of a patient with cutaneous diphtheria caused by toxigenic corynebacterium ulcerans who developed a right hand flexor sheath infection and symptoms of sepsis such as fever, tachycardia, and elevated c-reactive protein, after contact with domestic cats and dogs, and a fox. we summarise the epidemiology, clinical presentation, microbiology, diagnosis, therapy, and public health aspects of this disease, with emphasis on improving recognition. in many european countries, c ulcer ... | 2015 | 26189434 |
| draft genome sequences of two toxigenic corynebacterium ulcerans strains. | here, we present the draft genome sequences of two toxigenic corynebacterium ulcerans strains isolated from two different patients: one from a blood sample and the other from a scar exudate following surgery. although these two strains harbor the diphtheria toxin gene tox, no full prophage sequences were found in the flanking regions. | 2015 | 26112794 |
| colonization of human epithelial cell lines by corynebacterium ulcerans from human and animal sources. | corynebacterium ulcerans is an emerging pathogen transmitted by a zoonotic pathway to humans. despite rising numbers of infections and potentially fatal outcomes, data on the colonization of the human host are lacking up to now. in this study, adhesion of two c. ulcerans isolates to human epithelial cells, invasion of host cells and the function of two putative virulence factors with respect to these processes were investigated. c. ulcerans strains br-ad22 and 809 were able to adhere to detroit5 ... | 2015 | 26066797 |
| toxigenic corynebacterium ulcerans isolated from a free-roaming red fox (vulpes vulpes). | corynebacterium (c.) ulcerans could be isolated from the spleen of a red fox (vulpes vulpes) that had been found dead in the state of baden-württemberg, germany. pathohistological examination suggested that the fox had died of distemper, as was confirmed by pcr. the isolate was identified biochemically, by maldi-tof ms, ft-ir and by partial 16s rrna, rpob and tox gene sequencing. using the elek test the c. ulcerans isolate demonstrated diphtheria toxin production. ft-ir and sequencing data obtai ... | 2015 | 26054226 |
| possible human-to-human transmission of toxigenic corynebacterium ulcerans. | toxigenic corynebacterium ulcerans is an emerging cause of diphtheria. in contrast to the classical diphtheria pathogen c. diphtheriae, human-to-human transmission of this primarily zoonotic pathogen has not been clearly documented. here we report on a two-person cluster suggesting an initial zoonotic and a subsequent human-to-human transmission event. | 2015 | 26027917 |
| genome sequence of corynebacterium ulcerans strain frc11. | here, we present the genome sequence of corynebacterium ulcerans strain frc11. the genome includes one circular chromosome of 2,442,826 bp (53.35% g+c content), and 2,210 genes were predicted, 2,146 of which are putative protein-coding genes, with 12 rrnas and 51 trnas; 1 pseudogene was also identified. | 2015 | 25767241 |
| zoonotic transmission of toxigenic corynebacterium ulcerans strain, germany, 2012. | severe necrotizing fasciitis was diagnosed in a 53-year-old man in germany in 2012. toxigenic corynebacterium ulcerans was grown from a wound swab sample. one of the patient's 2 dogs was found to harbor a toxigenic c. ulcerans strain. results of next generation sequencing of both isolates supported recent zoonotic transmission of this bacterial pathogen. | 2015 | 25625779 |
| next generation sequencing analysis of nine corynebacterium ulcerans isolates reveals zoonotic transmission and a novel putative diphtheria toxin-encoding pathogenicity island. | toxigenic corynebacterium ulcerans can cause a diphtheria-like illness in humans and have been found in domestic animals, which were suspected to serve as reservoirs for a zoonotic transmission. additionally, toxigenic c. ulcerans were reported to take over the leading role in causing diphtheria in the last years in many industrialized countries. | 2014 | 25587356 |
| the detection of toxigenic corynebacterium ulcerans from cats with nasal inflammation in japan. | corynebacterium ulcerans (toxigenic c. ulcerans) produces the diphtheria toxin, which causes pharyngeal and cutaneous diphtheria-like disease in people, and this bacterium is commonly detected in dogs and cats that are reared at home. it is considered dangerous when a carrier animal becomes the source of infection in people. to investigate the carrier situation of toxigenic c. ulcerans of cats bred in japan, bacteria were isolated from 37 cats with a primary complaint of rhinitis in 16 veterinar ... | 2015 | 25578079 |
| genome sequence of corynebacterium ulcerans strain 210932. | in this work, we present the complete genome sequence of corynebacterium ulcerans strain 210932, isolated from a human. the species is an emergent pathogen that infects a variety of wild and domesticated animals and humans. it is associated with a growing number of cases of a diphtheria-like disease around the world. | 2014 | 25428977 |
| toxigenic corynebacterium ulcerans in a fatal human case and her feline contacts, france, march 2014. | in march 2014, a person in their eighties who was diagnosed with extensive cellulitis due to toxigenic corynebacterium ulcerans died from multiple organ failure. environmental investigation also isolated c. ulcerans in biological samples from two stray cats in contact with the case. this finding provides further evidence that pets can carry toxigenic c. ulcerans and may be a source of the infection in humans. | 2014 | 25306877 |
| corynebacterium species nasal carriage in pigs and their farmers in bavaria, germany: implications for public health. | reports on cases of human diphtheria caused by toxigenic corynebacterium ulcerans that were linked to occupational swine contact as well as isolation of c ulcerans from wild boars have suggested that pigs might serve as reservoir for human infections. therefore, a prevalence study on corynebacterium species nasal carriage in pigs and their farmers was performed between august 1 and december 31, 2009, in 41 swine farms from bavaria, germany. all 411 asymptomatic pigs and 29 of 30 healthy farmers ... | 2014 | 25037890 |
| diphtheria-like disease caused by toxigenic corynebacterium ulcerans strain. | | 2014 | 24960178 |
| unwanted baggage. | an elderly woman with a rapidly progressing lower leg ulcer presented with features of systemic inflammatory response syndrome (sirs). the ulcer had occurred after hitting her leg against a piece of luggage. the causative pathogen in our case was by corynebacterium ulcerans, demonstrated in bacterial cultures and by pcr. disease progression was stopped only by linezolid intravenous. after several other antibiotics failed to help. diphtheria is known to most physicians as a respiratory disease ca ... | 2013 | 23661657 |
| jugulodigastric lymph node inflammation derived from chronic atypical oropharyngeal phlogosis recurring annually after flu virus vaccination: a holistic vision of a clinical case solved after chlamydicidal antibiotic therapy. | in this report, we evaluated the case history of a patient with longstanding chronic pharyngitis who had periodic clinical manifestation for three years after a flu vaccine administration, and after various treatments tried to resolve the chronic pharyngitis with unsuccessful antibiotic and anti-inflammatory therapies. the patient occasionally presented a slight ocular inflammation, while dysuria occurred after sexual activity. the search for common pathogens by use of pharyngeal swabs resulted ... | 2017 | 23298475 |
| two cases of cutaneous diphtheria associated with occupational pig contact in germany. | in 2010, two independent cases of cutaneous diphtheria caused by toxigenic c. ulcerans were identified in germany. both patients had intense occupational contact with pigs. diagnostic work-up comprising biochemical differentiation, rpob sequencing, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (maldi-tof) analysis, real-time tox pcr and elek test as well as public health measures including an intensified source tracing involving 83 asymptomatic pigs of an associate ... | 2013 | 23280311 |
| subcutaneous abscess formation in the upper extremity caused by toxigenic corynebacterium ulcerans. | corynebacterium ulcerans is attracting attention as an emerging zoonosis that causes lymphadenitis, dermatitis and respiratory infections. we report here what appears to be the first case of subcutaneous abscess formation in the upper extremity due to toxigenic c. ulcerans in japan. awareness of the fact that c. ulcerans can cause a subcutaneous, elastic-hard, less-mobile mass with heat, redness and pain in the extremities is important for differential diagnosis. | 2013 | 23222862 |
| [case of acute pharyngitis caused by corynebacterium ulcerans in ibaraki prefecture]. | we report on the case of a 51-year-old woman who presented with refractory pharyngitis caused by toxigenic corynebacteriumn ulcerans (c. ulcerans). thick pseudomembrane formations and yellowish pus were observed in her nasopharynx. based on her clinical course and history of breeding cats, we considered c. ulcerans infection as the possible diagnosis. she was treated with macrolide administration and her symptoms immediately improved. c. ulcerans was identified in pus from the patient's pharynx ... | 2012 | 22991854 |
| [corynebacterium ulcerans infection in roe deer (capreolus capreolus)]. | this is the first report of a corynebacterium (c) ulcerans-infection in european roe deer (capreolus capreolus). the bacterium was isolated from a grapefruit sized abscess of an animal that had been shot. in addition to biochemical tests, the isolate was identified by fourier transform infrared spectroscopy (ft-ir) and partial sequencing of the rpob gene. the isolated bacteria showed phospholipase d activity that could be demonstrated by reverse camp-test. a tox-gene could be detected by pcr but ... | 2012 | 22515035 |
| rare human skin infection with corynebacterium ulcerans: transmission by a domestic cat. | corynebacterium ulcerans is mainly known for its ability to cause animal infections. some strains of c. ulcerans produce diphtheria toxin, which can cause life-threatening cardiopathies and neuropathies in humans. human cutaneous c. ulcerans infection is a very rare disease that mimics classical cutaneous diphtheria. we present a very rare case of a c. ulcerans skin infection caused by a non-diphtheria toxin-producing strain of c. ulcerans that resolved after 3 weeks of therapy with amoxicillin- ... | 2012 | 22403045 |
| toll-like receptor 2 and mincle cooperatively sense corynebacterial cell wall glycolipids. | nontoxigenic corynebacterium diphtheriae and corynebacterium ulcerans cause invasive disease in humans and animals. host sensing of corynebacteria is largely uncharacterized, albeit the recognition of lipoglycans by toll-like receptor 2 (tlr2) appears to be important for macrophage activation by corynebacteria. the members of the order corynebacterineae (e.g., mycobacteria, nocardia, and rhodococci) share a glycolipid-rich cell wall dominated by mycolic acids (termed corynomycolic acids in coryn ... | 2017 | 28483856 |
| respiratory diphtheria due to corynebacterium ulcerans transmitted by a companion dog, italy 2014. | a serious respiratory tract infection due to corynebacterium ulcerans was observed in a 70-year-old woman. clinical presentation included pseudomembranes in the upper respiratory tract and lung involvement. c. ulcerans was recovered from the nose of the patient's dog. both dog's and patient's isolates belonged to sequence type 331. | 2017 | 28647898 |
| diphtheria in the postepidemic period, europe, 2000-2009. | diphtheria incidence has decreased in europe since its resurgence in the 1990s, but circulation continues in some countries in eastern europe, and sporadic cases have been reported elsewhere. surveillance data from diphtheria surveillance network countries and the world health organization european region for 2000-2009 were analyzed. latvia reported the highest annual incidence in europe each year, but the russian federation and ukraine accounted for 83% of all cases. over the past 10 years, dip ... | 2012 | 22304732 |
| erratum to: respiratory diphtheria due to corynebacterium ulcerans transmitted by a companion dog, italy 2014. | | 2017 | 28786003 |